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Micky Tortorella

Research Profile

Chemicals & Drugs

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Disorders

Osteoarthritis

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Blotting, Western

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Publications

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Anne-Marie Malfait; Nigel K Arden; Rosalina Das; Michael Doherty; Sally Doherty; Feng Gao; Deborah J Hart; Marie-Pierre Hellio Le Graverand-Gastineau; Paul E Leaverton; Rose A Maciewicz; Kenneth R Muir; Ara Schorscher-Petcu; Albert B Seymour; Robert E Sorge; Susanna G Sotocinal; Tim D Spector; Micky D Tortorella; Ana M Valdes; Frances L Vaughn; Linda S Wood; Weiya Zhang; Jeffrey S Mogil
A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.
Shiqiang Zhang; Ping Zhao; Daniela Zychlinski; Shen Chen; Yan Chen; Xiangpeng Guo; Wen Li; Xiaorong Liu; Hai Lu; Qiong Pan; Duanqing Pei; Axel Schambach; Micky D Tortorella; Yan Wang; Jianyong Xu; Miguel A Esteban
Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin.
Huey-Sheng Shieh; Alfredo G Tomasselli; Karl J Mathis; Mark E Schnute; Scott S Woodard; Nicole Caspers; Jennifer M Williams; James R Kiefer; Grace Munie; Arthur Wittwer; Anne-Marie Malfait; Micky D Tortorella
Structure analysis reveals the flexibility of the ADAMTS-5 active site.

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All Publications

2012: Anne-Marie Malfait; Nigel K Arden; Rosalina Das; Michael Doherty; Sally Doherty; Feng Gao; Deborah J Hart; Marie-Pierre Hellio Le Graverand-Gastineau; Paul E Leaverton; Rose A Maciewicz; Kenneth R Muir; Ara Schorscher-Petcu; Albert B Seymour; Robert E Sorge; Susanna G Sotocinal; Tim D Spector; Micky D Tortorella; Ana M Valdes; Frances L Vaughn; Linda S Wood; Weiya Zhang; Jeffrey S Mogil
A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.
Annals of the rheumatic diseases 2012;71(6):1042-8.
2011: Shiqiang Zhang; Ping Zhao; Daniela Zychlinski; Shen Chen; Yan Chen; Xiangpeng Guo; Wen Li; Xiaorong Liu; Hai Lu; Qiong Pan; Duanqing Pei; Axel Schambach; Micky D Tortorella; Yan Wang; Jianyong Xu; Miguel A Esteban
Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin.
Human molecular genetics 2011;20(16):3176-87.
2011: Huey-Sheng Shieh; Alfredo G Tomasselli; Karl J Mathis; Mark E Schnute; Scott S Woodard; Nicole Caspers; Jennifer M Williams; James R Kiefer; Grace Munie; Arthur Wittwer; Anne-Marie Malfait; Micky D Tortorella
Structure analysis reveals the flexibility of the ADAMTS-5 active site.
Protein science : a publication of the Protein Society 2011;20(4):735-44.
2010: Sangwon Byun; Micky D Tortorella; Anne-Marie Malfait; Kam Fok; Eliot H Frank; Alan J Grodzinsky
Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions.
Archives of biochemistry and biophysics 2010;499(1-2):32-9.
2010: Anne-Marie Malfait; J Ritchie; A S Gil; J-S Austin; J Hartke; W Qin; Micky D Tortorella; J S Mogil
ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(4):572-80.
2009: Marc Zack; M A Melton; J L Stock; C E Storer; R A Barve; J C Minnerly; D J Weiss; J A Stejskal; Micky D Tortorella; J R Turk; K M Shevlin; Anne-Marie Malfait
Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8).
Clinical and experimental immunology 2009;158(2):246-56.
2009: Micky D Tortorella; Alfredo G Tomasselli; Karl J Mathis; Mark E Schnute; Scott S Woodard; Grace Munie; Jennifer M Williams; Nicole Caspers; Arthur J Wittwer; Anne-Marie Malfait; Huey-Sheng Shieh
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors.
The Journal of biological chemistry 2009;284(36):24185-91.
2009: Marc Zack; Anne-Marie Malfait; Adam P Skepner; Matthew P Yates; David W Griggs; Troii Hall; Robert L Hills; James T Alston; Olga V Nemirovskiy; Melissa R Radabaugh; Joseph W Leone; Elizabeth C Arner; Micky D Tortorella
ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271).
Arthritis and rheumatism 2009;60(9):2704-13.
2009: Anne-Marie Malfait; Micky D Tortorella; J Thompson; R Hills; D M Meyer; B D Jaffee; K Chinn; N Ghoreishi-Haack; S Markosyan; Elizabeth C Arner
Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(5):627-35.
2009: Micky D Tortorella; Fransiska Malfait; Ruteja A Barve; Huey-Sheng Shieh; Anne-Marie Malfait
A review of the ADAMTS family, pharmaceutical targets of the future.
Current pharmaceutical design 2009;15(20):2359-74.
2008: Anne-Marie Malfait; Elizabeth C Arner; Ruo-Hua Song; James T Alston; Stella Markosyan; Nicholas Staten; Zhiyong Yang; David W Griggs; Micky D Tortorella
Proprotein convertase activation of aggrecanases in cartilage in situ.
Archives of biochemistry and biophysics 2008;478(1):43-51.
2008: Micky D Tortorella; Anne-Marie Malfait
Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.
Current pharmaceutical biotechnology 2008;9(1):16-23.
2008: Huey-Sheng Shieh; Karl J Mathis; Jennifer M Williams; Robert Hills; Joe F Wiese; Timothy Benson; James R Kiefer; Margaret H Marino; Jeffery N Carroll; Joseph W Leone; Anne-Marie Malfait; Elizabeth C Arner; Micky D Tortorella; Alfredo G Tomasselli
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).
The Journal of biological chemistry 2008;283(3):1501-7.
2007: Wade S Blair; Joan Cao; Lynn Jackson; Judith Jimenez; Qinghai Peng; Hua Wu; Jason Isaacson; Scott L Butler; Alex Chu; Joanne Graham; Anne-Marie Malfait; Micky D Tortorella; Amy K Patick
Identification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gp160 processing.
Antimicrobial agents and chemotherapy 2007;51(10):3554-61.
2007: Arthur J Wittwer; Robert Hills; Robert H Keith; Grace E Munie; Elizabeth C Arner; Charles P Anglin; Anne-Marie Malfait; Micky D Tortorella
Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).
Biochemistry 2007;46(21):6393-401.
2007: Troii Hall; Kam F Fok; Min M Liu; James F Zobel; Margaret H Marino; Anne-Marie Malfait; Micky D Tortorella; Alfredo G Tomasselli
A high performance liquid chromatography assay for monitoring proprotein convertase activity.
Journal of chromatography. A 2007;1148(1):46-54.
2007: Robert Hills; Richard Mazzarella; Kam F Fok; Min Liu; Olga Nemirovskiy; Joseph Leone; Marc Zack; Elizabeth C Arner; Malini Viswanathan; Aida Abujoub; Arumugam Muruganandam; Daniel Sexton; Gary J Bassill; Aaron K Sato; Anne-Marie Malfait; Micky D Tortorella
Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.
The Journal of biological chemistry 2007;282(15):11101-9.
2007: Ruo-Hua Song; Micky D Tortorella; Anne-Marie Malfait; James T Alston; Zhiyong Yang; Elizabeth C Arner; David W Griggs
Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.
Arthritis and rheumatism 2007;56(2):575-85.
2006: Marc Zack; Elizabeth C Arner; Charles P Anglin; James T Alston; Anne-Marie Malfait; Micky D Tortorella
Identification of fibronectin neoepitopes present in human osteoarthritic cartilage.
Arthritis and rheumatism 2006;54(9):2912-22.
2005: Micky D Tortorella; Elizabeth C Arner; Robert Hills; Jennifer Gormley; Kam F Fok; Lyle Pegg; Grace E Munie; Anne-Marie Malfait
ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.
Archives of biochemistry and biophysics 2005;444(1):34-44.
2004: Micky D Tortorella; Elizabeth C Arner; Robert Hills; Alan Easton; Jennifer Korte-Sarfaty; Kam F Fok; Arthur J Wittwer; Rui-Qin Liu; Anne-Marie Malfait
Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.
The Journal of biological chemistry 2004;279(17):17554-61.
2004: Ping Wang; Micky D Tortorella; Kristen England; Anne-Marie Malfait; Gary Thomas; Elizabeth C Arner; Duanqing Pei
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network.
The Journal of biological chemistry 2004;279(15):15434-40.
2003: Micky D Tortorella; Anne-Marie Malfait
The usual suspects: verdict not guilty?
Arthritis and rheumatism 2003;48(12):3304-7.
2003: Michael A Pratta; Wenqing Yao; Carl P Decicco; Micky D Tortorella; Rui-Qin Liu; Robert Copeland; Ronald L Magolda; Robert C Newton; James M Trzaskos; Elizabeth C Arner
Aggrecan protects cartilage collagen from proteolytic cleavage.
The Journal of biological chemistry 2003;278(46):45539-45.
2003: Robert J Cherney; Ruowei Mo; Dayton T Meyer; Li Wang; Wenqing Yao; Zelda R Wasserman; Rui-Qin Liu; Maryanne B Covington; Micky D Tortorella; Elizabeth C Arner; Mingxin Qian; David D Christ; James M Trzaskos; Robert C Newton; Ronald L Magolda; Carl P Decicco
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.
Bioorganic & medicinal chemistry letters 2003;13(7):1297-300.
2002: Micky D Tortorella; Rui-Qin Liu; Timothy C Burn; Robert C Newton; Elizabeth C Arner
Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).
Matrix biology : journal of the International Society for Matrix Biology 2002;21(6):499-511.
2002: Anne-Marie Malfait; Rui-Qin Liu; Kosei Ijiri; Setsuro Komiya; Micky D Tortorella
Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.
The Journal of biological chemistry 2002;277(25):22201-8.
2002: Yuji Yamanishi; David L Boyle; Melody Clark; Rich A Maki; Micky D Tortorella; Elizabeth C Arner; Gary S Firestein
Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1405-12.
2002: Mohamed Osman; Micky D Tortorella; Marco Londei; Sonia Quaratino
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases define the migratory characteristics of human monocyte-derived dendritic cells.
Immunology 2002;105(1):73-82.
2001: W Yao; Zelda R Wasserman; M Chao; G Reddy; E Shi; Rui-Qin Liu; Maryanne B Covington; Elizabeth C Arner; Michael A Pratta; Micky D Tortorella; Ronald L Magolda; R Newton; Mingxin Qian; Maria D Ribadeneira; David D Christ; Ruth R Wexler; Carl P Decicco
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
Journal of medicinal chemistry 2001;44(21):3347-50.
2001: Micky D Tortorella; Anne-Marie Malfait; C Deccico; Elizabeth C Arner
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(6):539-52.
2000: Michael A Pratta; Micky D Tortorella; Elizabeth C Arner
Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase.
The Journal of biological chemistry 2000;275(50):39096-102.
2000: Micky D Tortorella; Michael A Pratta; Rui-Qin Liu; I Abbaszade; H Ross; Timothy C Burn; Elizabeth C Arner
The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage.
The Journal of biological chemistry 2000;275(33):25791-7.
2000: Micky D Tortorella; Michael A Pratta; Rui-Qin Liu; J Austin; OH Ross; I Abbaszade; Timothy C Burn; Elizabeth C Arner
Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).
The Journal of biological chemistry 2000;275(24):18566-73.
1999: I Abbaszade; Rui-Qin Liu; F Yang; SA Rosenfeld; OH Ross; John R Link; D M Ellis; Micky D Tortorella; Michael A Pratta; JM Hollis; Richard Wynn; JL Duke; Henry J George; Milton C Hillman; KATHLEEN MURPHY; BH Wiswall; Robert Copeland; Carl P Decicco; Robert Bruckner; H Nagase; Y Itoh; Robert C Newton; Ronald L Magolda; James M Trzaskos; Timothy C Burn
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.
The Journal of biological chemistry 1999;274(33):23443-50.
1999: Elizabeth C Arner; Michael A Pratta; Carl P Decicco; Chu-Biao Xue; Robert C Newton; James M Trzaskos; Ronald L Magolda; Micky D Tortorella
Aggrecanase. A target for the design of inhibitors of cartilage degradation.
Annals of the New York Academy of Sciences 1999;878():92-107.
1999: Micky D Tortorella; Timothy C Burn; Michael A Pratta; I Abbaszade; JM Hollis; R Liu; SA Rosenfeld; Robert Copeland; Carl P Decicco; Richard Wynn; A Rockwell; F Yang; JL Duke; Kimberley Solomon; Henry J George; Robert Bruckner; H Nagase; Y Itoh; D M Ellis; H Ross; BH Wiswall; KATHLEEN MURPHY; Milton C Hillman; Gregory F Hollis; Robert C Newton; Ronald L Magolda; James M Trzaskos; Elizabeth C Arner
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
Science (New York, N.Y.) 1999;284(5420):1664-6.
1999: Elizabeth C Arner; Michael A Pratta; James M Trzaskos; Carl P Decicco; Micky D Tortorella
Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity.
The Journal of biological chemistry 1999;274(10):6594-601.
1998: Elizabeth C Arner; C E Hughes; Carl P Decicco; B Caterson; Micky D Tortorella
Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(3):214-28.
1998: Micky D Tortorella; Michael A Pratta; J W Fox; Elizabeth C Arner
The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
The Journal of biological chemistry 1998;273(10):5846-50.
1997: Micky D Tortorella; Elizabeth C Arner
A high-throughput assay for stromelysin using a casein-resorufin substrate.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46 Suppl 2():S122-3.
1997: Micky D Tortorella; Elizabeth C Arner
A fluorescent enzyme-linked immunosorbent assay (FELISA) for stromelysin using a polyclonal antisera to human stromelysin with broad species cross-reactivity.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46 Suppl 2():S120-1.
1997: Elizabeth C Arner; Carl P Decicco; Robert J Cherney; Micky D Tortorella
Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase.
The Journal of biological chemistry 1997;272(14):9294-9.
1995: Elizabeth C Arner; Micky D Tortorella
Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin-1.
Arthritis and rheumatism 1995;38(9):1304-14.