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Dilip Tosh

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P Suresh Jayasekara; T Santhosh Kumar; Steven M Moss; Khai Phan; Dilip K Tosh; Guofeng Zhang; Joseph J Barchi; Zhan-Guo Gao; Kenneth A Jacobson
Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles.
Eszter Kozma; Lucia Squarcialupi; Dilip K Tosh; John A Auchampach; Elizabeth T Gizewski; Kenneth A Jacobson
Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
Dilip K Tosh; Francesca Deflorian; Zhan-Guo Gao; Xiaohui Jiang; Steven M Moss; Silvia Paoletta; Khai Phan; Kenneth Alan Jacobson
Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.

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All Publications

2013: P Suresh Jayasekara; T Santhosh Kumar; Steven M Moss; Khai Phan; Dilip K Tosh; Guofeng Zhang; Joseph J Barchi; Zhan-Guo Gao; Kenneth A Jacobson
Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles.
Purinergic signalling 2013;9(2):183-98.
2013: Eszter Kozma; Lucia Squarcialupi; Dilip K Tosh; John A Auchampach; Elizabeth T Gizewski; Kenneth A Jacobson
Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
Biochemical pharmacology 2013;85(8):1171-81.
2012: Dilip K Tosh; Francesca Deflorian; Zhan-Guo Gao; Xiaohui Jiang; Steven M Moss; Silvia Paoletta; Khai Phan; Kenneth Alan Jacobson
Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.
Journal of medicinal chemistry 2012;55(18):8075-90.
2012: Dilip K Tosh; Tina C Wan; Khai Phan; John A Auchampach; Francesca Deflorian; Zhan-Guo Gao; Elizabeth Gizewski; Kenneth Alan Jacobson
Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.
Journal of medicinal chemistry 2012;55(10):4847-60.
2012: Dilip K Tosh; Fei Xu; Khai Phan; Raymond C Stevens; Ruben Abagyan; Francesca Deflorian; Andrei A Gakh; Zhan-Guo Gao; Kenneth Alan Jacobson; Vsevolod Katritch
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.
Journal of medicinal chemistry 2012;55(9):4297-308.
2012: Dilip K Tosh; Qiang Wei; Lena S Yoo; Francesca Deflorian; Zhan-Guo Gao; Khai Phan; Kenneth Alan Jacobson
Click modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.
Bioconjugate chemistry 2012;23(2):232-47.
2011: Angela Kecskés; Dilip K Tosh; Qiang Wei; Zhan-Guo Gao; Kenneth Alan Jacobson
GPCR ligand dendrimer (GLiDe) conjugates: adenosine receptor interactions of a series of multivalent xanthine antagonists.
Bioconjugate chemistry 2011;22(6):1115-27.
2010: Hiroshi Maruoka; Matthew O Barrett; Hyojin Ko; Dilip K Tosh; Artem Melman; Lauren E Burianek; Ramachandran Balasubramanian; Barkin Berk; Stefano Costanzi; T Kendall Harden; Kenneth Alan Jacobson
Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.
Journal of medicinal chemistry 2010;53(11):4488-501.
2010: Dilip K Tosh; Lena S Yoo; Moshe Chinn; Kunlun Hong; S Michael Kilbey; Matthew O Barrett; Ingrid P Fricks; T Kendall Harden; Zhan-Guo Gao; Kenneth Alan Jacobson
Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.
Bioconjugate chemistry 2010;21(2):372-84.
2010: Dilip K Tosh; Moshe Chinn; Lena S Yoo; Dong Wook Kang; Hans Luecke; Zhan-Guo Gao; Kenneth Alan Jacobson
2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A(3) adenosine receptor-selective agonists.
Bioorganic & medicinal chemistry 2010;18(2):508-17.
2009: Dilip K Tosh; Moshe Chinn; Andrei A Ivanov; Athena M Klutz; Zhan-Guo Gao; Kenneth Alan Jacobson
Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.
Journal of medicinal chemistry 2009;52(23):7580-92.
2009: Lak Shin Jeong; Dilip K Tosh; Won Jun Choi; Sang Kook Lee; You-Jin Kang; Sun Choi; Jin Hee Lee; Hankil Lee; Hyuk Woo Lee; Hea Ok Kim
Discovery of a new template for anticancer agents: 2'-deoxy-2'-fluoro-4'-selenoarabinofuranosyl-cytosine (2'-F-4'-seleno-ara-C).
Journal of medicinal chemistry 2009;52(17):5303-6.
2009: Lak Shin Jeong; Dilip K Tosh; Won Jun Choi
Development of next generation 4'-selenonucleosides.
Nucleic acids symposium series (2004) 2009;(53):7-8.
2009: Kenneth Alan Jacobson; Athena M Klutz; Dilip K Tosh; Andrei A Ivanov; Delia Preti; Pier Giovanni Baraldi
Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.
Handbook of experimental pharmacology 2009;(193):123-59.
2008: Lak Shin Jeong; Yoo Na Choi; Dilip K Tosh; Won Jun Choi; Hea Ok Kim; Jungwon Choi
Design and synthesis of novel 2',3'-dideoxy-4'-selenonucleosides as potential antiviral agents.
Bioorganic & medicinal chemistry 2008;16(23):9891-7.
2008: Lak Shin Jeong; Shantanu Pal; Seung Ah Choe; Won Jun Choi; Kenneth Alan Jacobson; Zhan-Guo Gao; Athena M Klutz; Xiyan Hou; Hea Ok Kim; Hyuk Woo Lee; Sang Kook Lee; Dilip K Tosh; Hyung Ryong Moon
Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2008;51(20):6609-13.
2008: Lak Shin Jeong; Dilip K Tosh; Won Jun Choi; Shantana Pal
Synthesis of fluoroneplanocin A.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2008;Chapter 14():Unit 14.6.
2008: Lak Shin Jeong; Hyuk Woo Lee; Hea Ok Kim; Dilip K Tosh; Shantanu Pal; Won Jun Choi; Zhan-Guo Gao; Amit R Patel; Wanda Williams; Kenneth Alan Jacobson; Hee-Doo Kim
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry letters 2008;18(5):1612-6.
2008: Lak Shin Jeong; Dilip K Tosh; Hea Ok Kim; Ting Wang; Xiyan Hou; Ho Seop Yun; Youngjoo Kwon; Sang Kook Lee; Jungwon Choi; Long Xuan Zhao
First synthesis of 4'-selenonucleosides showing unusual Southern conformation.
Organic letters 2008;10(2):209-12.
2008: Hankil Lee; Dilip K Tosh; Won Jun Choi; Yu Min Kim; Sang Kook Lee; Lak Shin Jeong
Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C).
Nucleic acids symposium series (2004) 2008;(52):639-40.
2007: Xiyan Hou; Hyuk Woo Lee; Dilip K Tosh; Long Xuan Zhao; Lak Shin Jeong
Alternative and improved syntheses of highly potent and selective A3 adenosine receptor agonists, Cl-IB-MECA and thio-Cl-IB-MECA.
Archives of pharmacal research 2007;30(10):1205-9.
2007: Ting Wang; Hyun Joo Lee; Dilip K Tosh; Hea Ok Kim; Shantanu Pal; Sun Choi; Yoonji Lee; Hyung Ryong Moon; Long Xuan Zhao; Kang Man Lee; Lak Shin Jeong
Design, synthesis, and molecular modeling studies of 5'-deoxy-5'-ureidoadenosine: 5'-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase.
Bioorganic & medicinal chemistry letters 2007;17(16):4456-9.
2007: Lak Shin Jeong; Seung Ah Choe; Prashantha Gunaga; Hea Ok Kim; Hyuk Woo Lee; Sang Kook Lee; Dilip K Tosh; Amit Patel; Krishnan K Palaniappan; Zhan-Guo Gao; Kenneth Alan Jacobson; Hyung Ryong Moon
Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.
Journal of medicinal chemistry 2007;50(14):3159-62.
2007: Lak Shin Jeong; Jeong A Lee; Hea Ok Kim; Dilip K Tosh; Hyung Ryong Moon; Seung-Jin Lee; Kang Man Lee; Yhun Y Sheen; Moon Woo Chun
Asymmetric synthesis of cyclopropyl-fused 2'-C-methylcarbanucleosides as potential anti-HCV agents.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1021-4.
2007: Lak Shin Jeong; Prashantha Gunaga; Hea Ok Kim; Dilip K Tosh; Hyuk Woo Lee; Seung Ah Choe; Hyung Ryong Moon; Zhan-Guo Gao; Kenneth Alan Jacobson; Moon Woo Chun
Stereoselective synthesis of 1'-functionalized-4'-thionucleosides.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1011-4.
2006: Jeong A Lee; Hea Ok Kim; Dilip K Tosh; Hyung Ryong Moon; Sanghee Kim; Lak Shin Jeong
Stereoselective synthesis of 2'-C-methyl-cyclopropyl-fused carbanucleosides as potential anti-HCV agents.
Organic letters 2006;8(22):5081-3.
2006: Prashantha Gunaga; Hea Ok Kim; Hyuk Woo Lee; Dilip K Tosh; Jae-Sang Ryu; Sun Choi; Lak Shin Jeong
Stereoselective functionalization of the 1'-position of 4'-thionucleosides.
Organic letters 2006;8(19):4267-70.