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Alessandro Tossi

Research Profile

Chemicals & Drugs

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Genes & Molecular Sequences

Amino Acid Sequences

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Microbial Sensitivity Tests

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Publications

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Nada Ilić; Monica Benincasa; Filomena Guida; Mario Novković; Alessandro Tossi; Daniela Xhindoli; Davor Juretić
Selective antimicrobial activity and mode of action of adepantins, glycine-rich peptide antibiotics based on anuran antimicrobial peptide sequences.
Immacolata Luisi; Elisa Maurizio; Silvia Pavan; Adriano Savoini; Daniele Sblattero; Riccardo Sgarra; Alessandro Tossi; Fabio Benedetti; Giampaolo Fontanive; Federico Berti
An albumin-derived peptide scaffold capable of binding and catalysis.
Mario Novković; Juraj Simunić; Alessandro Tossi; Viktor Bojović; Davor Juretić
DADP: the database of anuran defense peptides.

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All Publications

2013: Nada Ilić; Monica Benincasa; Filomena Guida; Mario Novković; Alessandro Tossi; Daniela Xhindoli; Davor Juretić
Selective antimicrobial activity and mode of action of adepantins, glycine-rich peptide antibiotics based on anuran antimicrobial peptide sequences.
Biochimica et biophysica acta 2013;1828(3):1004-12.
2013: Immacolata Luisi; Elisa Maurizio; Silvia Pavan; Adriano Savoini; Daniele Sblattero; Riccardo Sgarra; Alessandro Tossi; Fabio Benedetti; Giampaolo Fontanive; Federico Berti
An albumin-derived peptide scaffold capable of binding and catalysis.
PloS one 2013;8(2):e56469.
2012: Mario Novković; Juraj Simunić; Alessandro Tossi; Viktor Bojović; Davor Juretić
DADP: the database of anuran defense peptides.
Bioinformatics (Oxford, England) 2012;28(10):1406-7.
2012: Fabio Benedetti; Federico Berti; Sara Budal; Pietro Campaner; Francesca Dinon; Petia Genova; Radka Argirova; Vasil Atanassov; Alessandro Tossi; Anton Hinkov
Synthesis and biological activity of potent HIV-1 protease inhibitors based on Phe-Pro dihydroxyethylene isosteres.
Journal of medicinal chemistry 2012;55(8):3900-10.
2012: Valentina Tessera; Filomena Guida; Davor Juretić; Alessandro Tossi
Identification of antimicrobial peptides from teleosts and anurans in expressed sequence tag databases using conserved signal sequences.
The FEBS journal 2012;279(5):724-36.
2012: Linda Tomasinsig; Alessandro Tossi; Filomena Guida; Renata Piccinini; Michele Scarsini; Barbara Skerlavaj; Margherita Zanetti
Comparative activity and mechanism of action of three types of bovine antimicrobial peptides against pathogenic Prototheca spp.
Journal of peptide science : an official publication of the European Peptide Society 2012;18(2):105-13.
2012: Alessandro Tossi; Sotir Zahariev; Marco Scocchi; Renato Gennaro
Use of unnatural amino acids to probe structure-activity relationships and mode-of-action of antimicrobial peptides.
Methods in molecular biology (Clifton, N.J.) 2012;794():169-83.
2011: Marco Scocchi; Alessandro Tossi; Renato Gennaro
Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action.
Cellular and molecular life sciences : CMLS 2011;68(13):2317-30.
2011: Francesca Morgera; Sabrina Pacor; Luisa Creatti; Nikolinka Antcheva; Lisa Vaccari; Alessandro Tossi
Effects on antigen-presenting cells of short-term interaction with the human host defence peptide β-defensin 2.
The Biochemical journal 2011;436(3):537-46.
2011: Davor Juretić; Damir Vukičević; Dražen Petrov; Mario Novković; Viktor Bojović; Bono Lučić; Nada Ilić; Alessandro Tossi
Knowledge-based computational methods for identifying or designing novel, non-homologous antimicrobial peptides.
European biophysics journal : EBJ 2011;40(4):371-85.
2010: Lara Padovan; Ludovica Segat; Alessandra Pontillo; Nikolinka Antcheva; Alessandro Tossi; Sergio Crovella
Histatins in non-human primates: gene variations and functional effects.
Protein and peptide letters 2010;17(7):909-18.
2010: Vera Sass; Tanja Schneider; Miriam Wilmes; Christian Körner; Alessandro Tossi; Natalia Novikova; Olga Shamova; Hans-Georg Sahl
Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci.
Infection and immunity 2010;78(6):2793-800.
2010: Linda Tomasinsig; Gennyfer De Conti; Barbara Skerlavaj; Renata Piccinini; Maria Mazzilli; Francesca D'Este; Alessandro Tossi; Margherita Zanetti
Broad-spectrum activity against bacterial mastitis pathogens and activation of mammary epithelial cells support a protective role of neutrophil cathelicidins in bovine mastitis.
Infection and immunity 2010;78(4):1781-8.
2010: Lara Padovan; Ludovica Segat; Alessandro Tossi; Tercilio Calsa; Akio Kido Ederson; Lucas Brandao; Rafael L Guimarães; Valesca Pandolfi; Maria Clara Pestana-Calsa; Luís Carlos Belarmino; Ana Maria Benko-Iseppon; Sergio Crovella
Characterization of a new defensin from cowpea (Vigna unguiculata (L.) Walp.).
Protein and peptide letters 2010;17(3):297-304.
2009: Davor Juretić; Damir Vukicević; Nada Ilić; Nikolinka Antcheva; Alessandro Tossi
Computational design of highly selective antimicrobial peptides.
Journal of chemical information and modeling 2009;49(12):2873-82.
2009: Linda Tomasinsig; Francesca Morgera; Nikolinka Antcheva; Sabrina Pacor; Barbara Skerlavaj; Margherita Zanetti; Alessandro Tossi
Structure dependence of biological activities for primate cathelicidins.
Journal of peptide science : an official publication of the European Peptide Society 2009;15(9):576-82.
2009: Nikolinka Antcheva; Francesca Morgera; Luisa Creatti; Lisa Vaccari; Ulrike Pag; Sabrina Pacor; Yechiel Shai; Hans-Georg Sahl; Alessandro Tossi
Artificial beta-defensin based on a minimal defensin template.
The Biochemical journal 2009;421(3):435-47.
2009: Michela Foschiatti; Paola Cescutti; Alessandro Tossi; Roberto Rizzo
Inhibition of cathelicidin activity by bacterial exopolysaccharides.
Molecular microbiology 2009;72(5):1137-46.
2009: Francesca Morgera; Lisa Vaccari; Nikolinka Antcheva; Denis Scaini; Sabrina Pacor; Alessandro Tossi
Primate cathelicidin orthologues display different structures and membrane interactions.
The Biochemical journal 2009;417(3):727-35.
2009: Lara Padovan; Ludovica Segat; Alessandro Tossi; Nikolinka Antcheva; Ana Maria Benko-Iseppon; Akio Kido Ederson; Lucas Brandao; Tercilio Calsa; Sergio Crovella
A plant-defensin from sugarcane (Saccharum spp.).
Protein and peptide letters 2009;16(4):430-6.
2008: Linda Tomasinsig; Cinzia Pizzirani; Barbara Skerlavaj; Patrizia Pellegatti; Sara Gulinelli; Alessandro Tossi; Francesco Di Virgilio; Margherita Zanetti
The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner.
The Journal of biological chemistry 2008;283(45):30471-81.
2008: Vera Sass; Ulrike Pag; Alessandro Tossi; Gabriele Bierbaum; Hans-Georg Sahl
Mode of action of human beta-defensin 3 against Staphylococcus aureus and transcriptional analysis of responses to defensin challenge.
International journal of medical microbiology : IJMM 2008;298(7-8):619-33.
2008: Francesca Morgera; Nikolinka Antcheva; Sabrina Pacor; Luca Quaroni; Federico Berti; Lisa Vaccari; Alessandro Tossi
Structuring and interactions of human beta-defensins 2 and 3 with model membranes.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(4):518-23.
2008: Ulrike Pag; M Oedenkoven; V Sass; Y Shai; O Shamova; Nikolinka Antcheva; Alessandro Tossi; Hans-Georg Sahl
Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an alpha-helical 'sequence template'.
The Journal of antimicrobial chemotherapy 2008;61(2):341-52.
2008: Marco Scocchi; Maura Mattiuzzo; Monica Benincasa; Nikolinka Antcheva; Alessandro Tossi; Renato Gennaro
Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach: a tool to identify new bacterial targets amenable to the design of novel antibiotics.
Methods in molecular biology (Clifton, N.J.) 2008;494():161-76.
2008: Ludovica Segat; Alessandra Pontillo; Michele Milanese; Alessandro Tossi; Sergio Crovella
Evolution of the hepcidin gene in primates.
BMC genomics 2008;9():120.
2007: Francesco Fabris; Andrea Sgarro; Alessandro Tossi
Splitting the BLOSUM score into numbers of biological significance.
EURASIP journal on bioinformatics & systems biology 2007;():31450.
2007: V Camozzi; Alessandro Tossi; E Simoni; F Pagani; C M Francucci; Luigi Moro
Role of biochemical markers of bone remodeling in clinical practice.
Journal of endocrinological investigation 2007;30(6 Suppl):13-7.
2006: Monica Benincasa; Marco Scocchi; Sabrina Pacor; Alessandro Tossi; Donatella Nobili; Giancarlo Basaglia; Marina Busetti; Renato Gennaro
Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts.
The Journal of antimicrobial chemotherapy 2006;58(5):950-9.
2006: Igor Zelezetsky; Alessandro Tossi
Alpha-helical antimicrobial peptides--using a sequence template to guide structure-activity relationship studies.
Biochimica et biophysica acta 2006;1758(9):1436-49.
2006: Igor Zelezetsky; Alessandra Pontillo; Luca Puzzi; Nikolinka Antcheva; Ludovica Segat; Sabrina Pacor; Sergio Crovella; Alessandro Tossi
Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity.
The Journal of biological chemistry 2006;281(29):19861-71.
2006: Michele Boniotto; William J Jordan; Joyce Eskdale; Alessandro Tossi; Nikolinka Antcheva; Sergio Crovella; Nancy Connell; Grant Gallagher
Human beta-defensin 2 induces a vigorous cytokine response in peripheral blood mononuclear cells.
Antimicrobial agents and chemotherapy 2006;50(4):1433-41.
2006: Francesca Mazza; Elisa Tronconi; Antonella Valerio; Marcus Groettrup; Marcel Kremer; Alessandro Tossi; Fabio Benedetti; Antonietta Cargnel; Chiara Atzori
The non-peptidic HIV protease inhibitor tipranavir and two synthetic peptidomimetics (TS98 and TS102) modulate Pneumocystis carinii growth and proteasome activity of HEL299 cell line.
The Journal of eukaryotic microbiology 2006;53 Suppl 1():S144-6.
2005: Igor Zelezetsky; Ulrike Pag; Hans-Georg Sahl; Alessandro Tossi
Tuning the biological properties of amphipathic alpha-helical antimicrobial peptides: rational use of minimal amino acid substitutions.
Peptides 2005;26(12):2368-76.
2005: Marco Scocchi; Igor Zelezetsky; Monica Benincasa; Renato Gennaro; Andrea Mazzoli; Alessandro Tossi
Structural aspects and biological properties of the cathelicidin PMAP-36.
The FEBS journal 2005;272(17):4398-406.
2005: Igor Zelezetsky; Sabrina Pacor; Ulrike Pag; niv papo; Yechiel Shai; Hans-Georg Sahl; Alessandro Tossi
Controlled alteration of the shape and conformational stability of alpha-helical cell-lytic peptides: effect on mode of action and cell specificity.
The Biochemical journal 2005;390(Pt 1):177-88.
2005: Hans-Georg Sahl; Ulrike Pag; Sonja Bonness; Sandra Wagner; Nikolinka Antcheva; Alessandro Tossi
Mammalian defensins: structures and mechanism of antibiotic activity.
Journal of leukocyte biology 2005;77(4):466-75.
2005: Igor Zelezetsky; Ulrike Pag; Nikolinka Antcheva; Hans-Georg Sahl; Alessandro Tossi
Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.
Archives of biochemistry and biophysics 2005;434(2):358-64.
2005: Sergio Crovella; Nikolinka Antcheva; Igor Zelezetsky; Michele Boniotto; Sabrina Pacor; Maria Vittoria Verga Falzacappa; Alessandro Tossi
Primate beta-defensins--structure, function and evolution.
Current protein & peptide science 2005;6(1):7-21.
2005: Alessandro Tossi
Host defense peptides: roles and applications.
Current protein & peptide science 2005;6(1):1-3.
2004: Tanja Schneider; Maria Magdalena Senn; Brigitte Berger-Bächi; Alessandro Tossi; Hans-Georg Sahl; Imke Wiedemann
In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus.
Molecular microbiology 2004;53(2):675-85.
2004: ventura Mario; Michele Boniotto; M Pazienza; V Palumbo; Maria Francesca Cardone; Mariano Rocchi; Alessandro Tossi; A Amoroso; Sergio Crovella
Localization of beta-defensin genes in non human primates.
European journal of histochemistry : EJH 2004;48(2):185-90.
2004: Nikolinka Antcheva; Michele Boniotto; Igor Zelezetsky; Sabrina Pacor; Maria Vittoria Verga Falzacappa; Sergio Crovella; Alessandro Tossi
Effects of positively selected sequence variations in human and Macaca fascicularis beta-defensins 2 on antimicrobial activity.
Antimicrobial agents and chemotherapy 2004;48(2):685-8.
2003: Alessandro Tossi; Fabio Benedetti; Stefano Norbedo; Damiano Skrbec; Federico Berti; Domenico Romeo
Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases.
Bioorganic & medicinal chemistry 2003;11(22):4719-27.
2003: Michele Boniotto; Nikolinka Antcheva; Igor Zelezetsky; Alessandro Tossi; Valeria Palumbo; Maria Vittoria Verga Falzacappa; Silvia Sgubin; Laura Braida; Antonio Amoroso; Sergio Crovella
A study of host defence peptide beta-defensin 3 in primates.
The Biochemical journal 2003;374(Pt 3):707-14.
2003: Michele Boniotto; Alessandro Tossi; Massimiliano DelPero; S Sgubin; Nikolinka Antcheva; Daniela Santon; J Masters; Sergio Crovella
Evolution of the beta defensin 2 gene in primates.
Genes and immunity 2003;4(4):251-7.
2002: Anil C Nair; Irena Bonin; Alessandro Tossi; William J Wels; Stanislav Miertus
Computational studies of the resistance patterns of mutant HIV-1 aspartic proteases towards ABT-538 (ritonavir) and design of new derivatives.
Journal of molecular graphics & modelling 2002;21(3):171-9.
2002: Davide Pantarotto; Alberto Bianco; Federica Pellarini; Alessandro Tossi; Anna Giangaspero; Igor Zelezetsky; Jean-Paul Briand; Maurizio Prato
Solid-phase synthesis of fullerene-peptides.
Journal of the American Chemical Society 2002;124(42):12543-9.
2002: Sabrina Pacor; Anna Giangaspero; Marina Bacac; Gianni Sava; Alessandro Tossi
Analysis of the cytotoxicity of synthetic antimicrobial peptides on mouse leucocytes: implications for systemic use.
The Journal of antimicrobial chemotherapy 2002;50(3):339-48.
2002: Michele Boniotto; Alessandro Tossi; Sergio Crovella
Beta-defensin 2 in the rhesus monkey (Macaca mulatta) and the long-tailed macaque (M. fascicularis).
Clinical and diagnostic laboratory immunology 2002;9(2):503-4.
2002: Alessandro Tossi; L Sandri
Molecular diversity in gene-encoded, cationic antimicrobial polypeptides.
Current pharmaceutical design 2002;8(9):743-61.
2001: Anna Giangaspero; L Sandri; Alessandro Tossi
Amphipathic alpha helical antimicrobial peptides.
European journal of biochemistry / FEBS 2001;268(21):5589-600.
2001: Federica Pellarini; Davide Pantarotto; Tatiana Da Ros; Anna Giangaspero; Alessandro Tossi; Maurizio Prato
A novel [60]fullerene amino acid for use in solid-phase peptide synthesis.
Organic letters 2001;3(12):1845-8.
2000: Alessandro Tossi; Irena Bonin; Nikolinka Antcheva; Stefano Norbedo; Fabio Benedetti; Stanislav Miertus; Anil C Nair; T Maliar; F Dal Bello; G Palù; Domenico Romeo
Aspartic protease inhibitors. An integrated approach for the design andsynthesis of diaminodiol-based peptidomimetics.
European journal of biochemistry / FEBS 2000;267(6):1715-22.
2000: Alessandro Tossi; L Sandri; Anna Giangaspero
Amphipathic, alpha-helical antimicrobial peptides.
Biopolymers 2000;55(1):4-30.
1999: Fabio Benedetti; M Magnan; Stanislav Miertus; Stefano Norbedo; D Parat; Alessandro Tossi
Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres via epoxy alcohols derived from alpha-amino acids.
Bioorganic & medicinal chemistry letters 1999;9(20):3027-30.
1998: Vladimir Frecer; Stanislav Miertus; Alessandro Tossi; Domenico Romeo
Rational design of inhibitors for drug-resistant HIV-1 aspartic protease mutants.
Drug design and discovery 1998;15(4):211-31.
1998: E Tiozzo; G Rocco; Alessandro Tossi; Domenico Romeo
Wide-spectrum antibiotic activity of synthetic, amphipathic peptides.
Biochemical and biophysical research communications 1998;249(1):202-6.
1998: Anil C Nair; Stanislav Miertus; Alessandro Tossi; Domenico Romeo
A computational study of the resistance of HIV-1 aspartic protease to the inhibitors ABT-538 and VX-478 and design of new analogues.
Biochemical and biophysical research communications 1998;242(3):545-51.
1997: Alessandro Tossi; C Tarantino; Domenico Romeo
Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity.
European journal of biochemistry / FEBS 1997;250(2):549-58.
1997: Alessandro Tossi; Marco Scocchi; Margherita Zanetti; Renato Gennaro; P Storici; Domenico Romeo
An approach combining rapid cDNA amplification and chemical synthesis for the identification of novel, cathelicidin-derived, antimicrobial peptides.
Methods in molecular biology (Clifton, N.J.) 1997;78():133-50.
1996: P Storici; Alessandro Tossi; B Lenarcic; Domenico Romeo
Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides.
European journal of biochemistry / FEBS 1996;238(3):769-76.
1995: Alessandro Tossi; N Antcheva; Domenico Romeo; Stanislav Miertus
Development of pseudopeptide inhibitors of HIV-1 aspartic protease: analysis and tuning of the subsite specificity.
Peptide research 1995;8(6):328-34.
1995: Alessandro Tossi; Marco Scocchi; Margherita Zanetti; P Storici; Renato Gennaro
PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity.
European journal of biochemistry / FEBS 1995;228(3):941-6.
1994: Margherita Zanetti; P Storici; Alessandro Tossi; Marco Scocchi; Renato Gennaro
Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells.
The Journal of biological chemistry 1994;269(11):7855-8.
1994: Alessandro Tossi; Marco Scocchi; B Skerlavaj; Renato Gennaro
Identification and characterization of a primary antibacterial domain in CAP18, a lipopolysaccharide binding protein from rabbit leukocytes.
FEBS letters 1994;339(1-2):108-12.
1994: P Storici; Marco Scocchi; Alessandro Tossi; Renato Gennaro; Margherita Zanetti
Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA.
FEBS letters 1994;337(3):303-7.