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Michael Tota

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Chemicals & Drugs

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Margaret Wu; Sheo B Singh; Jun Wang; Christine C Chung; Gino Salituro; Bindhu V Karanam; Sang Ho Lee; Maryann Powles; Ken Ellsworth; Michael E Lassman; Corey Miller; Robert W Myers; Michael R Tota; Bei B Zhang; Cai Li
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Alexander Pasternak; Stephen D Goble; Reynalda K deJesus; Donna L Hreniuk; Christine C Chung; Michael R Tota; Paul Mazur; Scott Feighner; Andrew D Howard; Sander G Mills; Lihu Yang
Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.
Su Qian; Sheena Mumick; Peter Nizner; Michael R Tota; Joseph Menetski; Marc L Reitman; Douglas J MacNeil
Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.

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All Publications

2011: Margaret Wu; Sheo B Singh; Jun Wang; Christine C Chung; Gino Salituro; Bindhu V Karanam; Sang Ho Lee; Maryann Powles; Ken Ellsworth; Michael E Lassman; Corey Miller; Robert W Myers; Michael R Tota; Bei B Zhang; Cai Li
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(13):5378-83.
2009: Alexander Pasternak; Stephen D Goble; Reynalda K deJesus; Donna L Hreniuk; Christine C Chung; Michael R Tota; Paul Mazur; Scott Feighner; Andrew D Howard; Sander G Mills; Lihu Yang
Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.
Bioorganic & medicinal chemistry letters 2009;19(21):6237-40.
2008: Su Qian; Sheena Mumick; Peter Nizner; Michael R Tota; Joseph Menetski; Marc L Reitman; Douglas J MacNeil
Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.
Basic & clinical pharmacology & toxicology 2008;103(1):36-42.
2008: Christine C Chung; Kenji Ohwaki; Jonathan E Schneeweis; Erica Stec; Jeffrey P Varnerin; Paul N Goudreau; Amy Chang; Jason Cassaday; Lihu Yang; Takeru Yamakawa; Oleg Kornienko; Peter Hodder; James Inglese; Marc Ferrer; Berta Strulovici; Jun Kusunoki; Michael R Tota; Toshimitsu Takagi
A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production.
Assay and drug development technologies 2008;6(3):361-74.
2006: Alexey Rivkin; Yoona R Kim; Mark T Goulet; Nathan Bays; Armetta D Hill; Ilona Kariv; Stefan Krauss; Nicole Ginanni; Peter R Strack; Nancy E Kohl; Christine C Chung; Jeffrey P Varnerin; Paul N Goudreau; Amy Chang; Michael R Tota; Benito Munoz
3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(17):4620-3.
2004: Jeffrey P Varnerin; Christine C Chung; Sangita B Patel; Giovanna Scapin; Emma R Parmee; Nancy R Morin; Douglas J MacNeil; Doris F Cully; Lex H T Van Der Ploeg; Michael R Tota
Expression, refolding, and purification of recombinant human phosphodiesterase 3B: definition of the N-terminus of the catalytic core.
Protein expression and purification 2004;35(2):225-36.
2004: Giovanna Scapin; Sangita B Patel; Christine Chung; Jeffrey P Varnerin; Scott D Edmondson; Anthony Mastracchio; Emma R Parmee; Sheo B Singh; Joseph W Becker; Lex H T Van Der Ploeg; Michael R Tota
Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.
Biochemistry 2004;43(20):6091-100.
2004: Sangita B Patel; Jeffrey P Varnerin; Michael R Tota; Scott D Edmondson; Emma R Parmee; Joseph W Becker; Giovanna Scapin
Crystallization and preliminary X-ray diffraction analysis of the catalytic domain of recombinant human phosphodiesterase 3B.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 1):169-71.
2003: Scott D Edmondson; Anthony Mastracchio; Jiafang He; Christine C Chung; Michael J Forrest; Scott Hofsess; Euan MacIntyre; Joseph Metzger; Naphtali O'Connor; Kajal Patel; Xinchun Tong; Michael R Tota; Lex H T Van Der Ploeg; Jeffrey P Varnerin; Michael H Fisher; Matthew J Wyvratt; Ann E Weber; Emma R Parmee
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(22):3983-7.
2003: Christine Chung; Jeffrey P Varnerin; Nancy R Morin; Douglas J MacNeil; Sheo B Singh; Sangita Patel; Giovanna Scapin; Lex H T Van Der Ploeg; Michael R Tota
The role of tryptophan 1072 in human PDE3B inhibitor binding.
Biochemical and biophysical research communications 2003;307(4):1045-50.
2002: Douglas J MacNeil; Andrew D Howard; Xiaoming Guan; Tung M Fong; Ravi P Nargund; Maria A Bednarek; Mark T Goulet; David Weinberg; Alison M Strack; Donald J Marsh; Howard Y Chen; Chun-Pyn Shen; Airu S Chen; Charles I Rosenblum; Tanya MacNeil; Michael R Tota; Euan D MacIntyre; Lex H T Van Der Ploeg
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
European journal of pharmacology 2002;450(1):93-109.
2002: Chun-Pyn Shen; K K Wu; Lauren P Shearman; Ramon E Camacho; Michael R Tota; Tung M Fong; Lex H T Van Der Ploeg
Plasma agouti-related protein level: a possible correlation with fasted and fed states in humans and rats.
Journal of neuroendocrinology 2002;14(8):607-10.
2002: Douglas J MacNeil; Andrew D Howard; Xiaoming Guan; Tung M Fong; Ravi P Nargund; Maria A Bednarek; Mark T Goulet; David Weinberg; Alison M Strack; Donald J Marsh; Howard Y Chen; Chun-Pyn Shen; Airu S Chen; Charles I Rosenblum; Tanya MacNeil; Michael R Tota; Euan D MacIntyre; Lex H T Van Der Ploeg
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
European journal of pharmacology 2002;440(2-3):141-57.
2000: Ying-Kui Yang; Tung M Fong; Chris J Dickinson; C Mao; Ji-yao Li; Michael R Tota; Ralph T Mosley; Lex H T Van Der Ploeg; Ira Gantz
Molecular determinants of ligand binding to the human melanocortin-4 receptor.
Biochemistry 2000;39(48):14900-11.
1999: Michael R Tota; T S Smith; C Mao; Tanya MacNeil; Ralph T Mosley; Lex H T Van Der Ploeg; Tung M Fong
Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.
Biochemistry 1999;38(3):897-904.
1998: Jeffrey P Varnerin; T Smith; Charles I Rosenblum; Aurawan Vongs; B A Murphy; C Nunes; TN Mellin; J J King; B W Burgess; Beth Junker; M Chou; Patricia J Hey; Easter G Frazier; D Euan MacIntyre; Lex H T Van Der Ploeg; Michael R Tota
Production of leptin in Escherichia coli: a comparison of methods.
Protein expression and purification 1998;14(3):335-42.
1998: Charles I Rosenblum; Aurawan Vongs; Michael R Tota; Jeffrey P Varnerin; Easter G Frazier; Doris F Cully; MA Morsy; Lex H T Van Der Ploeg
A rapid, quantitative functional assay for measuring leptin.
Molecular and cellular endocrinology 1998;143(1-2):117-23.
1998: Tung M Fong; Ruey-Ruey C Huang; Michael R Tota; C Mao; T Smith; Jeffrey P Varnerin; VV Karpitskiy; James E Krause; Lex H T Van Der Ploeg
Localization of leptin binding domain in the leptin receptor.
Molecular pharmacology 1998;53(2):234-40.
1998: MA Morsy; M C Gu; J Z Zhao; DJ Holder; I T Rogers; Walter J Pouch; Sherri L Motzel; Hilton J Klein; S K Gupta; X Liang; Michael R Tota; Charles I Rosenblum; CT Caskey
Leptin gene therapy and daily protein administration: a comparative study in the ob/ob mouse.
Gene therapy 1998;5(1):8-18.
1997: Tung M Fong; C Mao; Tanya MacNeil; Rubana N Kalyani; T Smith; David Weinberg; Michael R Tota; Lex H T Van Der Ploeg
ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors.
Biochemical and biophysical research communications 1997;237(3):629-31.
1997: Margaret A Cascieri; E Ber; Tung M Fong; Jeffrey J Hale; F Tang; LL Shiao; Sander G Mills; Malcolm MacCoss; Sharon Sadowski; Michael R Tota; Catherine D Strader
Characterization of the binding and activity of a high affinity, pseudoirreversible morpholino tachykinin NK1 receptor antagonist.
European journal of pharmacology 1997;325(2-3):253-61.
1997: Gary G Chicchi; Margaret A Cascieri; M P Graziano; T Calahan; Michael R Tota
Fluorescein-Trp25-exendin-4, a biologically active fluorescent probe for the human GLP-1 receptor.
Peptides 1997;18(2):319-21.
1996: Charles I Rosenblum; Michael R Tota; Doris F Cully; T Smith; R Collum; S Qureshi; J Fred Hess; M S Phillips; Patricia J Hey; Aurawan Vongs; Tung M Fong; L Xu; H Y Chen; Roy G Smith; C Schindler; Lex H T Van Der Ploeg
Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells.
Endocrinology 1996;137(11):5178-81.
1996: K E Mazina; Catherine D Strader; Michael R Tota; S Daniel; Tung M Fong
Purification and reconstitution of a recombinant human neurokinin-1 receptor.
Journal of receptor and signal transduction research 1996;16(3-4):191-207.
1995: Michael R Tota; L Xu; A Sirotina; Catherine D Strader; M P Graziano
Interaction of [fluorescein-Trp25]glucagon with the human glucagon receptor expressed in Drosophila Schneider 2 cells.
The Journal of biological chemistry 1995;270(44):26466-72.
1995: Catherine D Strader; Tung M Fong; M P Graziano; Michael R Tota
The family of G-protein-coupled receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(9):745-54.
1994: Michael R Tota; S Daniel; A Sirotina; K E Mazina; Tung M Fong; J Longmore; Catherine D Strader
Characterization of a fluorescent substance P analog.
Biochemistry 1994;33(44):13079-86.
1994: Catherine D Strader; Tung M Fong; Michael R Tota; D Underwood; R A Dixon
Structure and function of G protein-coupled receptors.
Annual review of biochemistry 1994;63():101-32.
1991: Michael R Tota; Mari Rios Candelore; R A Dixon; Catherine D Strader
Biophysical and genetic analysis of the ligand-binding site of the beta-adrenoceptor.
Trends in pharmacological sciences 1991;12(1):4-6.
1990: Michael R Tota; Catherine D Strader
Characterization of the binding domain of the beta-adrenergic receptor with the fluorescent antagonist carazolol. Evidence for a buried ligand binding site.
The Journal of biological chemistry 1990;265(28):16891-7.