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Teruji Totsuka

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Osamu Yamaji; Hisashi Arase; Atsuhiko Hasegawa; Takanori Kanai; Takashi Nagaishi; Tetsuya Nakamura; Ryuichi Okamoto; Michio Onizawa; Masahiro Suzuki; Teruji Totsuka; Kiichiro Tsuchiya; Naoto Tsuge; Mamoru Watanabe
The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis.
Tamako Shinohara; Yasuhiro Nemoto; Takanori Kanai; Kaori Kameyama; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Teruji Totsuka; Koichi Ikuta; Mamoru Watanabe
Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.
Masakazu Nagahori; Sea Bong Hyun; Teruji Totsuka; Ryuichi Okamoto; Erika Kuwahara; Toru Takebayashi; Makoto Naganuma; Mamoru Watanabe
Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population.

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All Publications

2012: Osamu Yamaji; Hisashi Arase; Atsuhiko Hasegawa; Takanori Kanai; Takashi Nagaishi; Tetsuya Nakamura; Ryuichi Okamoto; Michio Onizawa; Masahiro Suzuki; Teruji Totsuka; Kiichiro Tsuchiya; Naoto Tsuge; Mamoru Watanabe
The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(6):2524-36.
2011: Tamako Shinohara; Yasuhiro Nemoto; Takanori Kanai; Kaori Kameyama; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Teruji Totsuka; Koichi Ikuta; Mamoru Watanabe
Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2623-32.
2010: Masakazu Nagahori; Sea Bong Hyun; Teruji Totsuka; Ryuichi Okamoto; Erika Kuwahara; Toru Takebayashi; Makoto Naganuma; Mamoru Watanabe
Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population.
Journal of gastroenterology 2010;45(10):1008-13.
2010: Kaori Kameyama; Yasuhiro Nemoto; Takanori Kanai; Tamako Shinohara; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Naoya Sakamoto; Teruji Totsuka; Toshifumi Hibi; Mamoru Watanabe
IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.
European journal of immunology 2010;40(9):2423-36.
2009: Yasuhiro Nemoto; Takanori Kanai; Kaori Kameyama; Tamako Shinohara; Naoya Sakamoto; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Tetsuo Sudo; Satoshi Matsumoto; Mamoru Watanabe
Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5059-68.
2009: Takayuki Tomita; Takanori Kanai; Teruji Totsuka; Yasuhiro Nemoto; Ryuichi Okamoto; Kiichiro Tsuchiya; Naoya Sakamoto; Toshiaki Ohteki; Toshifumi Hibi; Mamoru Watanabe
IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis.
European journal of immunology 2009;39(10):2737-47.
2009: Takanori Kanai; Yasuhiro Nemoto; Nobuhiko Kamada; Teruji Totsuka; Tadakazu Hisamatsu; Mamoru Watanabe; Toshifumi Hibi
Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease.
Current opinion in gastroenterology 2009;25(4):306-13.
2009: Takanori Kanai; Yasuhiro Nemoto; Takayuki Tomita; Teruji Totsuka; Mamoru Watanabe; Toshifumi Hibi
Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable.
Inflammatory bowel diseases 2009;15(6):926-34.
2009: Teruji Totsuka; Takanori Kanai; Yasuhiro Nemoto; Takayuki Tomita; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Naoya Sakamoto; Hisaya Akiba; Ko Okumura; Hideo Yagita; Mamoru Watanabe
RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):6079-87.
2009: Michio Onizawa; Takashi Nagaishi; Takanori Kanai; Ken-ichi Nagano; Shigeru Oshima; Yasuhiro Nemoto; Atsushi Yoshioka; Teruji Totsuka; Ryuichi Okamoto; Tetsuya Nakamura; Naoya Sakamoto; Kiichiro Tsuchiya; Kazuhiro Aoki; Keiichi Ohya; Hideo Yagita; Mamoru Watanabe
Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(4):G850-9.
2008: Toshimitsu Fujii; Takayuki Tomita; Takanori Kanai; Yasuhiro Nemoto; Teruji Totsuka; Naoya Sakamoto; Tetsuya Nakamura; Kiichiro Tsuchiya; Ryuichi Okamoto; Mamoru Watanabe
FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.
European journal of immunology 2008;38(12):3290-303.
2008: Takayuki Tomita; Takanori Kanai; Yasuhiro Nemoto; Toshimitsu Fujii; Kengo Nozaki; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Naoya Sakamoto; Teruji Totsuka; Mamoru Watanabe
Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice.
Inflammatory bowel diseases 2008;14(12):1630-40.
2008: Yasuhiro Nemoto; Takanori Kanai; Shuji Tohda; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Naoya Sakamoto; Tetsuya Fukuda; Osamu Miura; Hideo Yagita; Mamoru Watanabe
Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis.
Inflammatory bowel diseases 2008;14(11):1491-503.
2008: Teruji Totsuka; Takanori Kanai; Yasuhiro Nemoto; Takayuki Tomita; Kiichiro Tsuchiya; Naoya Sakamoto; Ryuichi Okamoto; Mamoru Watanabe
Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis.
European journal of immunology 2008;38(5):1275-86.
2008: Takayuki Tomita; Takanori Kanai; Toshimitsu Fujii; Yasuhiro Nemoto; Ryuichi Okamoto; Kiichiro Tsuchiya; Teruji Totsuka; Naoya Sakamoto; Mamoru Watanabe
Continuous generation of colitogenic CD4(+) T cells in persistent colitis.
European journal of immunology 2008;38(5):1264-74.
2008: Takayuki Tomita; Takanori Kanai; Toshimitsu Fujii; Yasuhiro Nemoto; Ryuichi Okamoto; Kiichiro Tsuchiya; Teruji Totsuka; Naoya Sakamoto; Shizuo Akira; Mamoru Watanabe
MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5291-9.
2008: Takayuki Tomita; Takanori Kanai; Yasuhiro Nemoto; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Naoya Sakamoto; Mamoru Watanabe
Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):383-90.
2008: Yoshiaki Ito; Takanori Kanai; Teruji Totsuka; Ryuichi Okamoto; Ken Tsuchiya; Yasuhiro Nemoto; A Yoshioka; T Tomita; T Nagaishi; N Sakamoto; T Sakanishi; Ko Okumura; Hideo Yagita; Masahiko Watanabe
Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(1):G199-207.
2007: Shin Makita; Takanori Kanai; Yasuhiro Nemoto; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Masafumi Yamamoto; Hiroshi Kiyono; Mamoru Watanabe
Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4937-46.
2007: Teruji Totsuka; Takanori Kanai; Yasuhiro Nemoto; Shin Makita; Ryuichi Okamoto; Kiichiro Tsuchiya; Mamoru Watanabe
IL-7 Is essential for the development and the persistence of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4737-48.
2007: Takanori Kanai; Shin Makita; Takahiro Kawamura; Yasuhiro Nemoto; Daisuke Kubota; Kazuyoshi Nagayama; Teruji Totsuka; Mamoru Watanabe
Extracorporeal elimination of TNF-alpha-producing CD14(dull)CD16(+) monocytes in leukocytapheresis therapy for ulcerative colitis.
Inflammatory bowel diseases 2007;13(3):284-90.
2007: Yasuhiro Nemoto; Takanori Kanai; Shin Makita; Ryuichi Okamoto; Teruji Totsuka; Kiyoshi Takeda; Mamoru Watanabe
Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.
Gastroenterology 2007;132(1):176-89.
2006: Rei Fujii; Takanori Kanai; Yasuhiro Nemoto; Shin Makita; Shigeru Oshima; Ryuichi Okamoto; Ken Tsuchiya; Teruji Totsuka; Masahiko Watanabe
FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(2):G267-74.
2006: Takanori Kanai; Koji Uraushihara; Teruji Totsuka; Yasuhiro Nemoto; Rei Fujii; Takahiro Kawamura; Shin Makita; Daisuke Sawada; Hideo Yagita; Ko Okumura; Mamoru Watanabe
Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis.
Journal of gastroenterology and hepatology 2006;21(7):1136-42.
2006: Takanori Kanai; K Tanimoto; Yasuhiro Nemoto; Rei Fujii; Shin Makita; Teruji Totsuka; Masahiko Watanabe
Naturally arising CD4+CD25+ regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L- effector memory T cells.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(5):G1051-8.
2006: Takanori Kanai; Takahiro Kawamura; Taeko Dohi; Shin Makita; Yasuhiro Nemoto; Teruji Totsuka; Mamoru Watanabe
TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice.
Inflammatory bowel diseases 2006;12(2):89-99.
2005: Teruji Totsuka; Takanori Kanai; Shin Makita; Rei Fujii; Yasuhiro Nemoto; Shigeru Oshima; Ryuichi Okamoto; Akemi Koyanagi; Hisaya Akiba; Ko Okumura; Hideo Yagita; Mamoru Watanabe
Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells.
European journal of immunology 2005;35(6):1773-85.
2005: Akihiro Araki; Takanori Kanai; Takahiro Ishikura; Shin Makita; Koji Uraushihara; Ryoichi Iiyama; Teruji Totsuka; Kiyoshi Takeda; Shizuo Akira; Mamoru Watanabe
MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis.
Journal of gastroenterology 2005;40(1):16-23.
2004: Shin Makita; Takanori Kanai; Shigeru Oshima; Koji Uraushihara; Teruji Totsuka; Taisuke Sawada; Tetsuya Nakamura; Kazutaka Koganei; Tsuneo Fukushima; Mamoru Watanabe
CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3119-30.
2004: Takahiro Kawamura; Takanori Kanai; Taeko Dohi; Koji Uraushihara; Teruji Totsuka; Ryoichi Iiyama; Chikara Taneda; Motomi Yamazaki; Tetsuya Nakamura; Tetsuya Higuchi; Yuichi Aiba; Takeshi Tsubata; Mamoru Watanabe
Ectopic CD40 ligand expression on B cells triggers intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6388-97.
2004: Toshiro Sato; Takanori Kanai; Mamoru Watanabe; Atsushi Sakuraba; Susumu Okamoto; Takaaki Nakai; Akira Okazawa; Nagamu Inoue; Teruji Totsuka; Motomi Yamazaki; Richard A Kroczek; Tsuneo Fukushima; Hiromasa Ishii; Toshifumi Hibi
Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease.
Gastroenterology 2004;126(3):829-39.
2004: Kenichi Ishii; Takanori Kanai; Teruji Totsuka; Koji Uraushihara; Takahiro Ishikura; Motomi Yamazaki; Ryuichi Okamoto; Akihiro Araki; Tatsuya Miyata; Katsunari Tezuka; Tetsuya Nakamura; Mamoru Watanabe
Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis.
Journal of gastroenterology and hepatology 2004;19(2):174-81.
2003: Ryoichi Iiyama; Takanori Kanai; Koji Uraushihara; Takahiro Ishikura; Shin Makita; Teruji Totsuka; Motomi Yamazaki; Tetsuya Nakamura; Tatsuya Miyata; Hideo Yoshida; O Takeuchi; K Hoshino; Kiyoshi Takeda; Hiromichi Ishikawa; Shizuo Akira; Masahiko Watanabe
Normal development of the gut-associated lymphoid tissue except Peyer's patch in MyD88-deficient mice.
Scandinavian journal of immunology 2003;58(6):620-7.
2003: Takanori Kanai; Teruji Totsuka; Koji Uraushihara; Shin Makita; Tetsuya Nakamura; Kazutaka Koganei; Tsuneo Fukushima; Hisaya Akiba; Hideo Yagita; Ko Okumura; Utako Machida; Hideyuki Iwai; Miyuki Azuma; Lieping Chen; Mamoru Watanabe
Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4156-63.
2003: Shin Makita; Takanori Kanai; S Matsumoto; Ryoichi Iiyama; Koji Uraushihara; Teruji Totsuka; Motomi Yamazaki; Tetsuya Nakamura; Hiromichi Ishikawa; Masahiko Watanabe
The role of cryptopatch-derived intraepithelial lymphocytes in the development of chronic ileocecitis.
Scandinavian journal of immunology 2003;58(4):428-35.
2003: N Dan; Takanori Kanai; Teruji Totsuka; Ryoichi Iiyama; Motomi Yamazaki; Tokihiko Sawada; Tatsuya Miyata; Hideo Yagita; Ko Okumura; Masahiko Watanabe
Ameliorating effect of anti-Fas ligand MAb on wasting disease in murine model of chronic colitis.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(4):G754-60.
2003: Takahiro Ishikura; Takanori Kanai; Koji Uraushihara; Ryoichi Iiyama; Shin Makita; Teruji Totsuka; Motomi Yamazaki; Taisuke Sawada; Tetsuya Nakamura; Tatsuya Miyata; Tetsuji Kitahora; Toshifumi Hibi; Tomoaki Hoshino; Mamoru Watanabe
Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice.
Journal of gastroenterology and hepatology 2003;18(8):960-9.
2003: Koji Uraushihara; Takanori Kanai; Kwibeom Ko; Teruji Totsuka; Shin Makita; Ryoichi Iiyama; Tetsuya Nakamura; Mamoru Watanabe
Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):708-16.
2003: Ryoichi Iiyama; Takanori Kanai; Koji Uraushihara; Teruji Totsuka; Tetsuya Nakamura; Tatsuya Miyata; Hideo Yagita; A Kushi; K Suzuki; Katsunari Tezuka; Masahiko Watanabe
The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches.
Immunology letters 2003;88(1):63-70.
2003: Takanori Kanai; Koji Uraushihara; Teruji Totsuka; Akira Okazawa; Toshifumi Hibi; Shigeru Oshima; Tatsuya Miyata; Tetsuya Nakamura; Mamoru Watanabe
Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.
Current drug targets. Inflammation and allergy 2003;2(2):131-6.
2003: Teruji Totsuka; Takanori Kanai; Koji Uraushihara; Ryoichi Iiyama; Motomi Yamazaki; Hisaya Akiba; Hideo Yagita; Ko Okumura; Masahiko Watanabe
Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(4):G595-603.
2003: Teruji Totsuka; Takanori Kanai; Ryoichi Iiyama; Koji Uraushihara; Motomi Yamazaki; Ryuichi Okamoto; Toshifumi Hibi; Katsunari Tezuka; Miyuki Azuma; Hisaya Akiba; Hideo Yagita; Ko Okumura; Mamoru Watanabe
Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis.
Gastroenterology 2003;124(2):410-21.
2002: Takanori Kanai; Teruji Totsuka; Katsunari Tezuka; Mamoru Watanabe
ICOS costimulation in inflammatory bowel disease.
Journal of gastroenterology 2002;37 Suppl 14():78-81.
2002: Takanori Kanai; Ryoichi Ilyama; Takahiro Ishikura; Koji Uraushihara; Teruji Totsuka; Motomi Yamazaki; Tetsuya Nakamuma; Mamoru Watanabe
Role of the innate immune system in the development of chronic colitis.
Journal of gastroenterology 2002;37 Suppl 14():38-42.
2001: Takanori Kanai; Masahiko Watanabe; Akira Okazawa; Toshiro Sato; Motomi Yamazaki; Shinichiro Okamoto; Hiromasa Ishii; Teruji Totsuka; Ryoichi Iiyama; Ryuichi Okamoto; M Ikeda; M Kurimoto; Kiyoshi Takeda; Shizuo Akira; Toshifumi Hibi
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease.
Gastroenterology 2001;121(4):875-88.