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Nick Totty

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Alejandra Collazos; Gavin Kelly; Harry Mellor; Nicholas Michael; Leon C H Pang; Nick Totty; Richard D H Whelan; Peter J Parker
Site recognition and substrate screens for PKN family proteins.
Svend Kjaer; Sarah Hanrahan; Nick Totty; Neil McDonald
Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations.
Eddy T H Goh; Olivier E Pardo; Nicholas Michael; Andrew Niewiarowski; Nick Totty; Dariya Volkova; Irina R Tsaneva; Michael J Seckl; Ivan T Gout
Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.

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All Publications

2011: Alejandra Collazos; Gavin Kelly; Harry Mellor; Nicholas Michael; Leon C H Pang; Nick Totty; Richard D H Whelan; Peter J Parker
Site recognition and substrate screens for PKN family proteins.
The Biochemical journal 2011;438(3):535-43.
2010: Svend Kjaer; Sarah Hanrahan; Nick Totty; Neil McDonald
Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations.
Nature structural & molecular biology 2010;17(6):726-31.
2010: Eddy T H Goh; Olivier E Pardo; Nicholas Michael; Andrew Niewiarowski; Nick Totty; Dariya Volkova; Irina R Tsaneva; Michael J Seckl; Ivan T Gout
Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.
The Journal of biological chemistry 2010;285(22):17065-76.
2008: Joanne Durgan; Angus J Cameron; Adrian T Saurin; Sarah Hanrahan; Nick Totty; Robert O Messing; Peter J Parker
The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily.
The Biochemical journal 2008;411(2):319-31.
2007: Karen S Rees-Unwin; Rachel A Craven; Emma Davenport; Sarah Hanrahan; Nick Totty; Ann M Dring; Rosamonde E Banks; Gareth J Morgan; Faith E Davies
Proteomic evaluation of pathways associated with dexamethasone-mediated apoptosis and resistance in multiple myeloma.
British journal of haematology 2007;139(4):559-67.
2007: Joanne Durgan; Nicholas Michael; Nick Totty; Peter J Parker
Novel phosphorylation site markers of protein kinase C delta activation.
FEBS letters 2007;581(18):3377-81.
2007: Hayley Whitaker; David P B Stanbury; Claire Brinham; Joanne Girling; Sarah Hanrahan; Nick Totty; David E Neal
Labeling and identification of LNCaP cell surface proteins: a pilot study.
The Prostate 2007;67(9):943-54.
2007: G C Fox; M Shafiq; David Briggs; Philip P Knowles; M Collister; M J Didmon; Vasso Makrantoni; Robin J Dickinson; Sarah Hanrahan; Nick Totty; M J R Stark; Stephen M Keyse; Neil McDonald
Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases.
Nature 2007;447(7143):487-92.
2007: Richard D Byrne; Marie Garnier-Lhomme; Kevin Han; Michael Dowicki; Nick Michael; Nick Totty; Vanessa Zhendre; Aeri Cho; Trevor R Pettitt; Michael J O Wakelam; Dominic L Poccia; Banafshé Larijani
PLCgamma is enriched on poly-phosphoinositide-rich vesicles to control nuclear envelope assembly.
Cellular signalling 2007;19(5):913-22.
2006: Rachel A Craven; Sarah Hanrahan; Nick Totty; Patricia Harnden; Anthea J Stanley; Eamonn R Maher; Adrian L Harris; William S Trimble; Peter J Selby; Rosamonde E Banks
Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma.
Proteomics 2006;6(13):3880-93.
2006: Rachel A Craven; Anthea J Stanley; Sarah Hanrahan; James Dods; Richard Unwin; Nick Totty; Patricia Harnden; Ian Eardley; Peter J Selby; Rosamonde E Banks
Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma.
Proteomics 2006;6(9):2853-64.
2005: Kirsi Riento; Nick Totty; villalonga priam; Ritu Garg; Rosa M Guasch; Anne J Ridley
RhoE function is regulated by ROCK I-mediated phosphorylation.
The EMBO journal 2005;24(6):1170-80.
2004: Rainy Mears; Rachel A Craven; Sarah Hanrahan; Nick Totty; Carol Upton; Sarah L Young; Poulam Patel; Peter J Selby; Rosamonde E Banks
Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry.
Proteomics 2004;4(12):4019-31.
2004: Rachel A Craven; Anthea J Stanley; Sarah Hanrahan; Nick Totty; David P Jackson; Razvan Popescu; Allen Taylor; Jürgen Frey; Peter J Selby; Poulam M Patel; Rosamonde E Banks
Identification of proteins regulated by interferon-alpha in resistant and sensitive malignant melanoma cell lines.
Proteomics 2004;4(12):3998-4009.
2004: Hayley Whitaker; Sarah Hanrahan; Nick Totty; Simon C Gamble; Jonathan Waxman; Andrew C B Cato; Helen C Hurst; Charlotte L Bevan
Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(21):7392-401.
2004: Arian Dominic John laurence; Emmanuelle Astoul; Sarah Hanrahan; Nick Totty; Doreen A Cantrell
Identification of pro-interleukin 16 as a novel target of MAP kinases in activated T lymphocytes.
European journal of immunology 2004;34(2):587-97.
2003: Richard D Unwin; Rachel A Craven; Patricia Harnden; Sarah Hanrahan; Nick Totty; Margaret Knowles; Ian Eardley; Peter J Selby; Rosamonde E Banks
Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect.
Proteomics 2003;3(8):1620-32.
2003: Emmanuelle Astoul; Arian Dominic John laurence; Nick Totty; Sandra Beer; Denis R Alexander; Doreen A Cantrell
Approaches to define antigen receptor-induced serine kinase signal transduction pathways.
The Journal of biological chemistry 2003;278(11):9267-75.
2003: Subham Basu; Nick Totty; Meredith S. Irwin; Marius Sudol; Julian Downward
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.
Molecular cell 2003;11(1):11-23.
2002: Jonathan Gilthorpe; Marie Vandromme; Tim Brend; Alejandro Gutman; Dennis Summerbell; Nick Totty; Peter W J Rigby
Spatially specific expression of Hoxb4 is dependent on the ubiquitous transcription factor NFY.
Development (Cambridge, England) 2002;129(16):3887-99.
2002: Rachel A Craven; Nick Totty; Patricia Harnden; Peter J Selby; Rosamonde E Banks
Laser capture microdissection and two-dimensional polyacrylamide gel electrophoresis: evaluation of tissue preparation and sample limitations.
The American journal of pathology 2002;160(3):815-22.
2002: L Miguel Martins; Ingram Iaccarino; Tencho Tenev; Stephen Gschmeissner; Nick Totty; Nick Lemoine; John Savopoulos; Carol W Gray; Caretha L Creasy; Colin Dingwall; Julian Downward
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.
The Journal of biological chemistry 2002;277(1):439-44.
2001: Graham Craggs; PM Finan; D Lawson; J Wingfield; Timothy Perera; S Gadher; Nick Totty; Stuart Kellie
A nuclear SH3 domain-binding protein that colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks.
The Journal of biological chemistry 2001;276(32):30552-60.
2000: Jennifer Hirst; Winnie W Y Lui; Nicholas A Bright; Nick Totty; Matthew N J Seaman; Margaret S Robinson
A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.
The Journal of cell biology 2000;149(1):67-80.
1999: Sarah L Hunt; J J Hsuan; Nick Totty; Richard J Jackson
unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA.
Genes & development 1999;13(4):437-48.
1998: P F McKay; Nesrina Imami; M Johns; David Taylor-Fishwick; L M Sedibane; Nick Totty; J Justin Hsuan; Donald B Palmer; Andrew J T George; B M Foxwell; Mary A Ritter
The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family.
European journal of immunology 1998;28(12):4071-83.
1998: Katia Vancompernolle; Franky Van Herreweghe; Gwenda Pynaert; M Van de Craen; K De Vos; Nick Totty; A Sterling; Walter Fiers; Peter Vandenabeele; Johan Grooten
Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity.
FEBS letters 1998;438(3):150-8.
1997: A Grogan; Emer P Reeves; Nicholas H Keep; Frans B Wientjes; Nick Totty; Al L Burlingame; J Justin Hsuan; Anthony W Segal
Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils.
Journal of cell science 1997;110 ( Pt 24)():3071-81.
1997: LM Machesky; Emer P Reeves; Frans B Wientjes; F J Mattheyse; A Grogan; Nick Totty; Al L Burlingame; J Justin Hsuan; Anthony W Segal
Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.
The Biochemical journal 1997;328 ( Pt 1)():105-12.
1997: Vera G Lelianova; Bazbek Davletov; AE Sterling; M Atiqur Rahman; Eugene V Grishin; Nick Totty; Yuri A Ushkaryov
Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors.
The Journal of biological chemistry 1997;272(34):21504-8.
1997: Takefumi Kawata; A Shevchenko; Masashi Fukuzawa; Keith A Jermyn; Nick Totty; Natasha V Zhukovskaya; AE Sterling; M Mann; Jeffrey G Williams
SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in dictyostelium.
Cell 1997;89(6):909-16.
1997: R Woscholski; PM Finan; E Radley; Nick Totty; AE Sterling; J Justin Hsuan; Michael D Waterfield; Peter J Parker
Synaptojanin is the major constitutively active phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase in rodent brain.
The Journal of biological chemistry 1997;272(15):9625-8.
1996: David R Booth; S Y Tan; Susanne E Booth; Glenys A Tennent; Winston L Hutchinson; J Justin Hsuan; Nick Totty; O Truong; Anne K Soutar; Philip N Hawkins; M Bruguera; J Caballería; M Solé; J M Campistol; Mark B Pepys
Hereditary hepatic and systemic amyloidosis caused by a new deletion/insertion mutation in the apolipoprotein AI gene.
The Journal of clinical investigation 1996;97(12):2714-21.
1996: A Tanveer; Sukaina Virji; L Andreeva; Nick Totty; J Justin Hsuan; JM Ward; Martin Crompton
Involvement of cyclophilin D in the activation of a mitochondrial pore by Ca2+ and oxidant stress.
European journal of biochemistry / FEBS 1996;238(1):166-72.
1996: Yoshinori Okabayashi; Y Sugimoto; Nick Totty; J Justin Hsuan; Y Kido; K Sakaguchi; Ivan T Gout; M D Waterfield; Masato Kasuga
Interaction of Shc with adaptor protein adaptins.
The Journal of biological chemistry 1996;271(9):5265-9.
1996: T Kitamura; Y Kitamura; Kazuyoshi Yonezawa; Nick Totty; Ivan T Gout; Kenta Hara; M D Waterfield; M Sakaue; Wataru Ogawa; Masato Kasuga
Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck.
Biochemical and biophysical research communications 1996;219(2):509-14.
1995: David R Booth; S Y Tan; Susanne E Booth; J Justin Hsuan; Nick Totty; O Nguyen; T Hutton; D M Vigushin; Glenys A Tennent; Winston L Hutchinson
A new apolipoprotein Al variant, Trp50Arg, causes hereditary amyloidosis.
QJM : monthly journal of the Association of Physicians 1995;88(10):695-702.
1994: W J Shen; J Avery; Nick Totty; J Justin Hsuan; Michael Whitaker; Stephen E Moss
Identification and partial sequence analysis of novel annexins in Lytechinus pictus oocytes.
The Biochemical journal 1994;304 ( Pt 3)():911-6.
1994: M Kracht; O Truong; Nick Totty; M Shiroo; Jeremy Saklatvala
Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.
The Journal of experimental medicine 1994;180(6):2017-25.
1994: D M Vigushin; Philip N Hawkins; J Justin Hsuan; Nick Totty; Mark B Pepys
AL kappa amyloid in a solitary extradural lymphoma.
Journal of neurology, neurosurgery, and psychiatry 1994;57(6):751-4.
1994: Peter J Jose; DA Griffiths-Johnson; PD Collins; D T Walsh; Redwan Moqbel; Nick Totty; O Truong; J Justin Hsuan; Timothy J Williams
Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.
The Journal of experimental medicine 1994;179(3):881-7.
1994: R Dhand; I Hiles; George Panayotou; S Roche; M J Fry; Ivan T Gout; Nick Totty; O Truong; P Vicendo; K Yonezawa
PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.
The EMBO journal 1994;13(3):522-33.
1994: Shamshad Cockcroft; G M Thomas; Amanda Fensome; B Geny; E Cunningham; Ivan T Gout; I Hiles; Nick Totty; O Truong; J Justin Hsuan
Phospholipase D: a downstream effector of ARF in granulocytes.
Science (New York, N.Y.) 1994;263(5146):523-6.
1994: F L Clottens; G M Holman; Geoffrey M Coast; Nick Totty; TK Hayes; I Kay; A I Mallet; M S Wright; J S Chung; O Truong
Isolation and characterization of a diuretic peptide common to the house fly and stable fly.
Peptides 1994;15(6):971-9.
1993: Frans B Wientjes; J Justin Hsuan; Nick Totty; Anthony W Segal
p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains.
The Biochemical journal 1993;296 ( Pt 3)():557-61.
1993: Ivan T Gout; R Dhand; I D Hiles; M J Fry; George Panayotou; P Das; O Truong; Nick Totty; J Justin Hsuan; G W Booker
The GTPase dynamin binds to and is activated by a subset of SH3 domains.
Cell 1993;75(1):25-36.
1993: G M Thomas; E Cunningham; Amanda Fensome; Andrew Ball; Nick Totty; O Truong; J Justin Hsuan; Shamshad Cockcroft
An essential role for phosphatidylinositol transfer protein in phospholipase C-mediated inositol lipid signaling.
Cell 1993;74(5):919-28.
1993: C Shapland; J J Hsuan; Nick Totty; D Lawson
Purification and properties of transgelin: a transformation and shape change sensitive actin-gelling protein.
The Journal of cell biology 1993;121(5):1065-73.
1993: Mark B Pepys; Philip N Hawkins; David R Booth; D M Vigushin; Glenys A Tennent; Anne K Soutar; Nick Totty; O Nguyen; CC Blake; C J Terry
Human lysozyme gene mutations cause hereditary systemic amyloidosis.
Nature 1993;362(6420):553-7.
1993: H White; Nick Totty; George Panayotou
Haemonectin, a granulocytic-cell-binding protein, is related to the plasma glycoprotein fetuin.
European journal of biochemistry / FEBS 1993;213(1):523-8.
1993: K Hughes; E Nikolakaki; S E Plyte; Nick Totty; James R Woodgett
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.
The EMBO journal 1993;12(2):803-8.
1992: I Kay; M Patel; Geoffrey M Coast; Nick Totty; A I Mallet; Graham J Goldsworthy
Isolation, characterization and biological activity of a CRF-related diuretic peptide from Periplaneta americana L.
Regulatory peptides 1992;42(3):111-22.
1992: C G Teahan; Nick Totty; Anthony W Segal
Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils.
The Biochemical journal 1992;286 ( Pt 2)():549-54.
1992: Anne K Soutar; Philip N Hawkins; D M Vigushin; Glenys A Tennent; Susanne E Booth; T Hutton; O Nguyen; Nick Totty; Terry Feest; J Justin Hsuan
Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7389-93.
1992: I D Hiles; M Otsu; Stefano Volinia; M J Fry; Ivan T Gout; R Dhand; George Panayotou; F Ruiz-Larrea; A Thompson; Nick Totty
Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit.
Cell 1992;70(3):419-29.
1991: A Abo; Edgar Pick; Alan Hall; Nick Totty; C G Teahan; Anthony W Segal
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.
Nature 1991;353(6345):668-70.
1991: I Kay; Colin Wheeler; Geoffrey M Coast; Nick Totty; O Cusinato; M Patel; Graham J Goldsworthy
Characterization of a diuretic peptide from Locusta migratoria.
Biological chemistry Hoppe-Seyler 1991;372(10):929-34.
1991: Peter J Jose; PD Collins; J A Perkins; B C Beaubien; Nick Totty; M D Waterfield; J Justin Hsuan; Timothy J Williams
Identification of a second neutrophil-chemoattractant cytokine generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to melanoma-growth-stimulatory activity.
The Biochemical journal 1991;278 ( Pt 2)():493-7.
1991: I Kay; Geoffrey M Coast; O Cusinato; Colin Wheeler; Nick Totty; Graham J Goldsworthy
Isolation and characterization of a diuretic peptide from Acheta domesticus. Evidence for a family of insect diuretic peptides.
Biological chemistry Hoppe-Seyler 1991;372(7):505-12.
1991: M D Garrett; G N Major; Nick Totty; Alan Hall
Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP.
The Biochemical journal 1991;276 ( Pt 3)():833-6.
1991: D Diekmann; S Brill; M D Garrett; Nick Totty; J Justin Hsuan; Clinton Monfries; C Hall; L Lim; Alan Hall
Bcr encodes a GTPase-activating protein for p21rac.
Nature 1991;351(6325):400-2.
1991: M Otsu; I Hiles; Ivan T Gout; M J Fry; F Ruiz-Larrea; George Panayotou; A Thompson; R Dhand; J Justin Hsuan; Nick Totty
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.
Cell 1991;65(1):91-104.
1991: E Meldrum; Ron Kriz; Nick Totty; Peter J Parker
A second gene product of the inositol-phospholipid-specific phospholipase C delta subclass.
European journal of biochemistry / FEBS 1991;196(1):159-65.
1990: B C Beaubien; PD Collins; Peter J Jose; Nick Totty; J Justin Hsuan; M D Waterfield; Timothy J Williams
A novel neutrophil chemoattractant generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to interleukin 8.
The Biochemical journal 1990;271(3):797-801.
1990: D Schaap; J Justin Hsuan; Nick Totty; Peter J Parker
Proteolytic activation of protein kinase C-epsilon.
European journal of biochemistry / FEBS 1990;191(2):431-5.
1990: C G Teahan; Nick Totty; Colin Casimir; Anthony W Segal
Purification of the 47 kDa phosphoprotein associated with the NADPH oxidase of human neutrophils.
The Biochemical journal 1990;267(2):485-9.
1989: J Davies; J Warwick; Nick Totty; R Philp; M Helfrich; M Horton
The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor.
The Journal of cell biology 1989;109(4 Pt 1):1817-26.
1988: M Katan; Ron Kriz; Nick Totty; R Philp; E Meldrum; R A Aldape; J L Knopf; Peter J Parker
Determination of the primary structure of PLC-154 demonstrates diversity of phosphoinositide-specific phospholipase C activities.
Cell 1988;54(2):171-7.
1988: Olwyn Westwood; M G Chapman; Nick Totty; R Philp; A E Bolton; N R Lazarus
N-terminal sequence analysis of human placental protein 14, purified in high yield from decidual cytosol.
Journal of reproduction and fertility 1988;82(2):493-500.
1988: M Katan; Ron Kriz; Nick Totty; R Philp; E Meldrum; R A Aldape; J Knopf; Peter J Parker
Primary structure of PLC-154.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():921-6.