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Lhousseine Touqui

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Disorders

Respiratory Distress Syndrome, Adult

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Publications

TOP 3
Ignacio Garcia-Verdugo; Dominique Leduc; Mario Ollero; Sonja Tattermusch; Fatima BenMohamed; Gilles Charpigny; Michel Chignard; Lhousseine Touqui
A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells.
Diane Barbier; Michel Chignard; Delphyne Descamps; Ignacio Garcia-Verdugo; Roxana Khazen; Julien Pothlichet; Karine Rousseau; Mustapha Si-Tahar; David Thornton; Lhousseine Touqui; Jean-Michel Sallenave
Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.
Lhousseine Touqui
Antisense inhibition of phospholipase A2: a new approach for already tested therapeutic targets for the treatment of sepsis*.

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2012: Ignacio Garcia-Verdugo; Dominique Leduc; Mario Ollero; Sonja Tattermusch; Fatima BenMohamed; Gilles Charpigny; Michel Chignard; Lhousseine Touqui
A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;40(3):714-23.
2012: Diane Barbier; Michel Chignard; Delphyne Descamps; Ignacio Garcia-Verdugo; Roxana Khazen; Julien Pothlichet; Karine Rousseau; Mustapha Si-Tahar; David Thornton; Lhousseine Touqui; Jean-Michel Sallenave
Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.
American journal of respiratory cell and molecular biology 2012;47(2):149-57.
2012: Lhousseine Touqui
Antisense inhibition of phospholipase A2: a new approach for already tested therapeutic targets for the treatment of sepsis*.
Critical care medicine 2012;40(7):2250-1.
2012: Fatima Ben Mohamed; Viviane Balloy; Michel Chignard; Ignacio Garcia-Verdugo; Mathieu Medina; Fatima Ben Mohamed; Reuben Ramphal; Lhousseine Touqui
A crucial role of Flagellin in the induction of airway mucus production by Pseudomonas aeruginosa.
PloS one 2012;7(7):e39888.
2011: Martina Wilke; David N Sheppard; Lhousseine Touqui; Jamil Aarbiou; Alice G M Bot; Ruvalic M Buijs-Offerman; William H Colledge; Hugo R de Jonge; Huub Jorna; Bob J Scholte
Mouse models of cystic fibrosis: phenotypic analysis and research applications.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2011;10 Suppl 2():S152-71.
2011: Jeevan Jyot; Viviane Balloy; Gregory Jouvion; Amrisha Verma; Lhousseine Touqui; Michel Huerre; Michel Chignard; Reuben Ramphal
Type II secretion system of Pseudomonas aeruginosa: in vivo evidence of a significant role in death due to lung infection.
The Journal of infectious diseases 2011;203(10):1369-77.
2011: Eric Morello; Emilie Saussereau; Damien Maura; Michel Huerre; Lhousseine Touqui; Laurent Debarbieux
Pulmonary bacteriophage therapy on Pseudomonas aeruginosa cystic fibrosis strains: first steps towards treatment and prevention.
PloS one 2011;6(2):e16963.
2010: Ignacio Garcia-Verdugo; Delphyne Descamps; Michel Chignard; Lhousseine Touqui; Jean-Michel Sallenave
Lung protease/anti-protease network and modulation of mucus production and surfactant activity.
Biochimie 2010;92(11):1608-17.
2010: Fariel Dif; Yong-Zheng Wu; P-R Burgel; M Ollero; Dominique Leduc; J Aarbiou; F Borot; I Garcia-Verdugo; C Martin; Michel Chignard; D Israel-Biet; Y Kita; B J Scholte; Lhousseine Touqui
Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(5):1120-30.
2010: Yongzheng Wu; Benoit Raymond; Pierre L Goossens; Elisabeth Njamkepo; Nicole Guiso; Miguel Paya; Lhousseine Touqui
Type-IIA secreted phospholipase A2 is an endogenous antibiotic-like protein of the host.
Biochimie 2010;92(6):583-7.
2010: Benoit Raymond; Lucas Ravaux; Sylvie Mémet; YongZheng Wu; Aude Sturny-Leclère; Dominique Leduc; Chantal Denoyelle; Pierre L Goossens; Miguel Payá; Michel Raymondjean; Lhousseine Touqui
Anthrax lethal toxin down-regulates type-IIA secreted phospholipase A(2) expression through MAPK/NF-kappaB inactivation.
Biochemical pharmacology 2010;79(8):1149-55.
2010: Laurent Debarbieux; Dominique Leduc; Damien Maura; Eric Morello; Alexis Criscuolo; Olivier Grossi; Viviane Balloy; Lhousseine Touqui
Bacteriophages can treat and prevent Pseudomonas aeruginosa lung infections.
The Journal of infectious diseases 2010;201(7):1096-104.
2010: Yong-Zheng Wu; Mohammad Abolhassani; Mario Ollero; Fariel Dif; Naonori Uozumi; Micheline Lagranderie; Takao Shimizu; Michel Chignard; Lhousseine Touqui
Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice.
Respiratory research 2010;11():49.
2010: Louis Le Heron; Christine Guillaume; Frédéric Velard; Julien Braux; Lhousseine Touqui; Sandra Moriceau; Isabelle Sermet-Gaudelus; Dominique Laurent-Maquin; Jacky Jacquot
Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2010;9(1):69-72.
2009: Benoit Raymond; Eric Batsché; Florence Boutillon; Yong-Zheng Wu; Dominique Leduc; Viviane Balloy; Eloïse Raoust; Christian Muchardt; Pierre L Goossens; Lhousseine Touqui
Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modification.
PLoS pathogens 2009;5(4):e1000359.
2009: Florence Borot; Diane-Lore Vieu; Grazyna Faure; Janine Fritsch; Julien Colas; Sandra Moriceau; Maryvonne Baudouin-Legros; Franck Brouillard; Jesus Ayala-Sanmartin; Lhousseine Touqui; Marc Chanson; Aleksander Edelman; Mario Ollero
Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells.
PloS one 2009;4(10):e7116.
2009: Eloïse Raoust; Viviane Balloy; Ignacio Garcia-Verdugo; Lhousseine Touqui; Reuben Ramphal; Michel Chignard
Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells.
PloS one 2009;4(10):e7259.
2009: Stéphanie Trudel; Mairead Kelly; Janine Fritsch; Thao Nguyen-Khoa; Patrice Thérond; Martine Couturier; Michal Dadlez; Janusz Debski; Lhousseine Touqui; Benoit Vallée; Mario Ollero; Aleksander Edelman; Franck Brouillard
Peroxiredoxin 6 fails to limit phospholipid peroxidation in lung from Cftr-knockout mice subjected to oxidative challenge.
PloS one 2009;4(6):e6075.
2008: Viviane Balloy; Jean-Michel Sallenave; Yongzheng Wu; Lhousseine Touqui; Jean-Paul Latgé; Mustapha Si-Tahar; Michel Chignard
Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.
The Journal of biological chemistry 2008;283(45):30513-21.
2008: Maria-Cristina Plotkowski; Bruno A Brandão; Maria-Cristina de Assis; Luis-Filipe P Feliciano; Benoit Raymond; Carla Freitas; Alessandra M Saliba; Jean-Marie Zahm; Lhousseine Touqui; Patrícia T Bozza
Lipid body mobilization in the ExoU-induced release of inflammatory mediators by airway epithelial cells.
Microbial pathogenesis 2008;45(1):30-7.
2007: Benoit Raymond; Dominique Leduc; Lucas Ravaux; Ronan Le Goffic; Thomas Candela; Michel Raymondjean; Pierre L Goossens; Lhousseine Touqui
Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages.
PLoS pathogens 2007;3(12):e187.
2006: Alexandre Demoule; François Decailliot; Björn Jonson; Christo Christov; Bernard Maitre; Lhousseine Touqui; Laurent Brochard; Christophe Delclaux
Relationship between pressure-volume curve and markers for collagen turn-over in early acute respiratory distress syndrome.
Intensive care medicine 2006;32(3):413-20.
2006: Alessandra M Saliba; Maria-Cristina de Assis; Rebeca Nishi; Benoit Raymond; Elizabeth de A Marques; Ulisses G Lopes; Lhousseine Touqui; Maria-Cristina Plotkowski
Implications of oxidative stress in the cytotoxicity of Pseudomonas aeruginosa ExoU.
Microbes and infection / Institut Pasteur 2006;8(2):450-9.
2005: Alessandra M Saliba; D O Nascimento; M C C Silva; Maria-Cristina Assis; Carlos Roberto Machado Gayer; Benoit Raymond; M G P Coelho; Elizabeth Andrade Marques; Lhousseine Touqui; Rodolpho M Albano; Ulisses G Lopes; D D Paiva; Patrícia T Bozza; Maria-Cristina Plotkowski
Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU.
Cellular microbiology 2005;7(12):1811-22.
2005: Alejandro Piris-Gimenez; Miguel Paya; Gérard Lambeau; Michel Chignard; Michèle Mock; Lhousseine Touqui; Pierre L Goossens
In vivo protective role of human group IIa phospholipase A2 against experimental anthrax.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6786-91.
2005: Samir Medjane; Benoit Raymond; Yongzheng Wu; Lhousseine Touqui
Impact of CFTR DeltaF508 mutation on prostaglandin E2 production and type IIA phospholipase A2 expression by pulmonary epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2005;289(5):L816-24.
2005: Lhousseine Touqui; Miguel Paya; Françoise Thouron; Annie Guiyoule; Maria Leticia Zarantonelli; Dominique Leduc; Yongzheng Wu; Muhamed-Kheir Taha; Jean-Michel Alonso
Neisseria meningitidis pili induce type-IIA phospholipase A2 expression in alveolar macrophages.
FEBS letters 2005;579(22):4923-7.
2005: Armand Mekontso Dessap; Stéphanie Honoré; Matthias Kirsch; Anne Plonquet; Eric Fernandez; Lhousseine Touqui; Jean-Pierre Farcet; Claude-James Soussy; Daniel Loisance; Christophe Delclaux
Blood neutrophil bactericidal activity against methicillin-resistant and methicillin-sensitive Staphylococcus aureus during cardiac surgery.
Shock (Augusta, Ga.) 2005;24(2):109-13.
2005: George Nakos; Eirini Kitsiouli; Eleana Hatzidaki; Vassilios Koulouras; Lhousseine Touqui; Marilena E Lekka
Phospholipases A2 and platelet-activating-factor acetylhydrolase in patients with acute respiratory distress syndrome.
Critical care medicine 2005;33(4):772-9.
2004: Alejandro Piris Gimenez; Yong-Zheng Wu; Miguel Paya; Christophe Delclaux; Lhousseine Touqui; Pierre L Goossens
High bactericidal efficiency of type iia phospholipase A2 against Bacillus anthracis and inhibition of its secretion by the lethal toxin.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):521-30.
2003: Lhousseine Touqui; Yong-Zheng Wu
Interaction of secreted phospholipase A2 and pulmonary surfactant and its pathophysiological relevance in acute respiratory distress syndrome.
Acta pharmacologica Sinica 2003;24(12):1292-6.
2003: Patricia Renesto; Pierre Dehoux; Edith Gouin; Lhousseine Touqui; Pascale Cossart; Didier Raoult
Identification and characterization of a phospholipase D-superfamily gene in rickettsiae.
The Journal of infectious diseases 2003;188(9):1276-83.
2003: Yong-Zheng Wu; Samir Medjane; Sophie Chabot; Flávia Saldanha Kubrusly; Isaias Raw; Michel Chignard; Lhousseine Touqui
Surfactant protein-A and phosphatidylglycerol suppress type IIA phospholipase A2 synthesis via nuclear factor-kappaB.
American journal of respiratory and critical care medicine 2003;168(6):692-9.
2003: Sophie Chabot; Kamen Koumanov; Gérard Lambeau; Michael H Gelb; Viviane Balloy; Michel Chignard; Jeffrey A Whitsett; Lhousseine Touqui
Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):995-1000.
2003: Habiba L Attalah; Yongzheng Wu; Mounia Alaoui-El-Azher; Françoise Thouron; Kamen Koumanov; C Wolf; Laurent Brochard; Alain Harf; Christophe Delclaux; Lhousseine Touqui
Induction of type-IIA secretory phospholipase A2 in animal models of acute lung injury.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(6):1040-5.
2003: Sophie Chabot; Laurent Salez; Francis X McCormack; Lhousseine Touqui; Michel Chignard
Surfactant protein A inhibits lipopolysaccharide-induced in vivo production of interleukin-10 by mononuclear phagocytes during lung inflammation.
American journal of respiratory cell and molecular biology 2003;28(3):347-53.
2002: Mounia Alaoui-El-Azher; Yongzheng Wu; Nathalie Havet; Alain Israël; Alain Lilienbaum; Lhousseine Touqui
Arachidonic acid differentially affects basal and lipopolysaccharide-induced sPLA(2)-IIA expression in alveolar macrophages through NF-kappaB and PPAR-gamma-dependent pathways.
Molecular pharmacology 2002;61(4):786-94.
2002: Yongzheng Wu; Monique Singer; Françoise Thouron; Mounia Alaoui-El-Azher; Lhousseine Touqui
Effect of surfactant on pulmonary expression of type IIA PLA(2) in an animal model of acute lung injury.
American journal of physiology. Lung cellular and molecular physiology 2002;282(4):L743-50.
2001: Lhousseine Touqui; Mounia Alaoui-El-Azher
Mammalian secreted phospholipases A2 and their pathophysiological significance in inflammatory diseases.
Current molecular medicine 2001;1(6):739-54.
2001: Laurent Salez; Viviane Balloy; Nico van Rooijen; Mai Lebastard; Lhousseine Touqui; Francis X McCormack; Michel Chignard
Surfactant protein A suppresses lipopolysaccharide-induced IL-10 production by murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6376-82.
2000: Mounia Alaoui-El-Azher; Nathalie Havet; Monique Singer; CH Dumarey; Lhousseine Touqui
Inhibition by unsaturated fatty acids of type II secretory phospholipase A2 synthesis in guinea-pig alveolar macrophages evidence for the eicosanoid-independent pathway.
European journal of biochemistry / FEBS 2000;267(12):3633-9.
2000: Sandrine Braud; Cassian Bon; Lhousseine Touqui; Carine M Mounier
Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid.
FEBS letters 2000;471(1):12-6.
1999: Lhousseine Touqui; Laurence Arbibe
A role for phospholipase A2 in ARDS pathogenesis.
Molecular medicine today 1999;5(6):244-9.
1999: A Berger; Nathalie Havet; D Vial; Laurence Arbibe; CH Dumarey; Malcolm Watson; Lhousseine Touqui
Dioleylphosphatidylglycerol inhibits the expression of type II phospholipase A2 in macrophages.
American journal of respiratory and critical care medicine 1999;159(2):613-8.
1998: Laurence Arbibe; Kamen Koumanov; D Vial; Catherine Rougeot; G Faure; Nathalie Havet; Shirley Longacre; B Boris Vargaftig; Gilbert Béréziat; D R Voelker; C Wolf; Lhousseine Touqui
Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction.
The Journal of clinical investigation 1998;102(6):1152-60.
1998: D Vial; Laurence Arbibe; Nathalie Havet; CH Dumarey; B Boris Vargaftig; Lhousseine Touqui
Down-regulation by prostaglandins of type-II phospholipase A2 expression in guinea-pig alveolar macrophages: a possible involvement of cAMP.
The Biochemical journal 1998;330 ( Pt 1)():89-94.
1997: R Hidi; D Vial; Nathalie Havet; A Berger; B Boris Vargaftig; Lhousseine Touqui
Inhibition by pulmonary surfactant Curosurf of secretory phospholipase A2 expression in guinea-pig alveolar macrophages.
Biochemical pharmacology 1997;54(9):1055-8.
1997: Laurence Arbibe; D Vial; Isabelle Rosinski-Chupin; Nathalie Havet; Michel Huerre; B Boris Vargaftig; Lhousseine Touqui
Endotoxin induces expression of type II phospholipase A2 in macrophages during acute lung injury in guinea pigs: involvement of TNF-alpha in lipopolysaccharide-induced type II phospholipase A2 synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):391-400.
1995: D Vial; M Señorale-Pose; Nathalie Havet; L Molio; B Boris Vargaftig; Lhousseine Touqui
Expression of the type-II phospholipase A2 in alveolar macrophages. Down-regulation by an inflammatory signal.
The Journal of biological chemistry 1995;270(29):17327-32.
1994: Carine M Mounier; B Boris Vargaftig; P A Franken; HM Verheij; Cassian Bon; Lhousseine Touqui
Platelet secretory phospholipase A2 fails to induce rabbit platelet activation and to release arachidonic acid in contrast with venom phospholipases A2.
Biochimica et biophysica acta 1994;1214(1):88-96.
1994: Lhousseine Touqui; N Herpin-Richard; R M Gene; E Jullian; D Aljabi; C Hamberger; B Boris Vargaftig; J F Dessange
Excretion of platelet activating factor-acetylhydrolase and phospholipase A2 into nasal fluids after allergenic challenge: possible role in the regulation of platelet activating factor release.
The Journal of allergy and clinical immunology 1994;94(1):109-19.
1993: R Hidi; B Boris Vargaftig; Lhousseine Touqui
Increased synthesis and secretion of a 14-kDa phospholipase A2 by guinea pig alveolar macrophages. Dissociation from arachidonic acid liberation and modulation by dexamethasone.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5613-23.
1993: F Suarez; B Rothhut; C Comera; Lhousseine Touqui; F R Marie; Caroline Silve
Expression of annexin I, II, V, and VI by rat osteoblasts in primary culture: stimulation of annexin I expression by dexamethasone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(10):1201-10.
1992: A Debbaghi; R Hidi; B Boris Vargaftig; Lhousseine Touqui
Inhibition of phospholipase A2 activity in guinea pig eosinophils by human recombinant IL-1 beta.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(4):1374-80.
1991: Lhousseine Touqui; C S Silva; B Boris Vargaftig
The metabolism of 1-acyl-PAF in rabbit platelets and its possible interaction with PAF.
Lipids 1991;26(12):992-6.
1989: Lhousseine Touqui; Martine Jandrot-Perrus; B Boris Vargaftig
Gamma-thrombin-induced phospholipase A2 activation in rabbit platelets: comparison with alpha-thrombin.
FEBS letters 1989;255(2):445-50.
1987: Lhousseine Touqui; A M Shaw; CH Dumarey; C Jacquemin; B Boris Vargaftig
The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets.
The Biochemical journal 1987;241(2):555-60.
1986: Lhousseine Touqui; B Rothhut; A M Shaw; A Fradin; B Boris Vargaftig; Françoise Russo-Marie
Platelet activation--a role for a 40K anti-phospholipase A2 protein indistinguishable from lipocortin.
Nature 1986;321(6066):177-80.
1985: I Maridonneau-Parini; A Fradin; Lhousseine Touqui; Françoise Russo-Marie
Effect of intracellular oxygen-free radicals on the formation of lipid derived mediators in rat renomedullary interstitial cells.
Biochemical pharmacology 1985;34(23):4137-43.
1985: F Wal; D Joseph; Lhousseine Touqui; B Boris Vargaftig
PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin.
Thrombosis and haemostasis 1985;53(1):99-104.
1985: Lhousseine Touqui; C Jacquemin; CH Dumarey; B Boris Vargaftig
1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle.
Biochimica et biophysica acta 1985;833(1):111-8.
1984: Lhousseine Touqui; Michel Chignard; C Jacquemin; F Wal; B Boris Vargaftig
Dissociation between inhibition of phospholipid methylation and production of PAF-acether by rabbit platelets.
Experientia 1984;40(4):374-7.
1983: Lhousseine Touqui; C Jacquemin; B Boris Vargaftig
Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite.
Biochemical and biophysical research communications 1983;110(3):890-3.