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Dirk Tourwé

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Alexandros Nikolaou; Marko Poglitsch; Géza Tóth; Dirk Tourwé; Jo A Van Ginderachter; Isabelle Van Den Eynde; Jayapal Reddy Mallareddy; Georges Vauquelin; Patrick M L Vanderheyden
[(3)H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase.
Alexandre Novoa; Peter W Schiller; Mariana Spetea; Sofie Stalmans; Dirk Tourwé; Sylvia Van Dorpe; Evelien Wynendaele; Johannes Zuegg; Cecilia Betti; Nathalie Bracke; Nga N Chung; Matthew A Cooper; Bart De Spiegeleer; Carole Lemieux; Steven Ballet
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.
Joanna Edyta Fraczek; Dirk Tourwé; Tamara Vanhaecke; Mathieu Vinken; Vera Rogiers
Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes.

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All Publications

2013: Alexandros Nikolaou; Marko Poglitsch; Géza Tóth; Dirk Tourwé; Jo A Van Ginderachter; Isabelle Van Den Eynde; Jayapal Reddy Mallareddy; Georges Vauquelin; Patrick M L Vanderheyden
[(3)H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase.
European journal of pharmacology 2013;702(1-3):93-102.
2012: Alexandre Novoa; Peter W Schiller; Mariana Spetea; Sofie Stalmans; Dirk Tourwé; Sylvia Van Dorpe; Evelien Wynendaele; Johannes Zuegg; Cecilia Betti; Nathalie Bracke; Nga N Chung; Matthew A Cooper; Bart De Spiegeleer; Carole Lemieux; Steven Ballet
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.
Journal of medicinal chemistry 2012;55(22):9549-61.
2012: Joanna Edyta Fraczek; Dirk Tourwé; Tamara Vanhaecke; Mathieu Vinken; Vera Rogiers
Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes.
Investigational new drugs 2012;30(4):1715-24.
2012: Heidi Demaegdt; Aneta Lukaszuk; Erzsébet Szemenyei; Géza Tóth; Dirk Tourwé; Jean-Paul De Backer; Georges Vauquelin
Angiotensin IV displays only low affinity for native insulin-regulated aminopeptidase (IRAP).
Fundamental & clinical pharmacology 2012;26(2):194-7.
2012: Simone Däpp; Elisa García Garayoa; Veronique Maes; Cristina Müller; Peter Bläuenstein; Luc Brans; Dirk Tourwé; Roger Schibli
PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with 177Lu-DOTA-bombesin analogues.
EJNMMI research 2012;2(1):24.
2012: Karel Guillemyn; Patrycja Kleczkowska; Piotr Kosson; Andrzej W Lipkowski; Alexandre Novoa; Peter W Schiller; Mariana Spetea; Dirk Tourwé; Isabelle Van den Eynde; Bart Vandormael; Muhammad Faheem Asim; Steven Ballet
In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera.
Molecular brain 2012;5():4.
2011: Bart Vandormael; Steven Ballet; Rien De Wachter; Pieter M S Hendrickx; Attila Keresztes; Jayapal R Mallareddy; José C Martins; Fanni Tóth; Géza Tóth; Dirk Tourwé
Asymmetric synthesis and conformational analysis by NMR spectroscopy and MD of Aba- and α-MeAba-containing dermorphin analogues.
ChemMedChem 2011;6(11):2035-47.
2011: Rien De Wachter; Atilla Keresztes; Didier Rognan; Géza Tóth; Steven Ballet; Chris de Graaf; Bart Vandormael; Dirk Tourwé
Synthesis, biological evaluation, and automated docking of constrained analogues of the opioid peptide H-Dmt-D-Ala-Phe-Gly-NH₂ using the 4- or 5-methyl substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold.
Journal of medicinal chemistry 2011;54(19):6538-47.
2011: Simone Däpp; Veronique Maes; Cristina Müller; Dirk Tourwé; Elisa García Garayoa; Luc Brans; Roger Schibli
PEGylation of (99m)Tc-labeled bombesin analogues improves their pharmacokinetic properties.
Nuclear medicine and biology 2011;38(7):997-1009.
2011: Faisal Alshoukr; Jacques Barbet; Luc Brans; Abdelhak Jallane; Sandra Mendes; Aurélie Prignon; Jean-Noël Talbot; Dirk Tourwé; Anne Gruaz-Guyon
Novel DOTA-neurotensin analogues for 111In scintigraphy and 68Ga PET imaging of neurotensin receptor-positive tumors.
Bioconjugate chemistry 2011;22(7):1374-85.
2011: Heidi Demaegdt; Paul Gard; Aneta Lukaszuk; Erzsébet Szemenyei; Géza Tóth; Dirk Tourwé; Jean-Paul De Backer; Georges Vauquelin
Binding of "AT4 receptor" ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells.
Molecular and cellular endocrinology 2011;339(1-2):34-44.
2011: Rui Yang; Ilse Smolders; Patrick M L Vanderheyden; Heidi Demaegdt; Ann Van Eeckhaut; Georges Vauquelin; Aneta Lukaszuk; Dirk Tourwé; Siew Yeen Chai; Anthony L Albiston; Clara Nahmias; Thomas Walther; Alain G Dupont
Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent.
Hypertension 2011;57(5):956-64.
2011: Steven Ballet; Debby Feytens; Koen Buysse; Nga N Chung; Carole Lemieux; Suneeta Tumati; Attila Keresztes; Joost Van Duppen; Josephine Lai; Eva Varga; Frank Porreca; Peter W Schiller; Jozef Vanden Broeck; Dirk Tourwé
Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.
Journal of medicinal chemistry 2011;54(7):2467-76.
2011: Jayapal Reddy Mallareddy; Attila Borics; Attila Keresztes; Katalin E Kövér; Dirk Tourwé; Géza Tóth
Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications.
Journal of medicinal chemistry 2011;54(5):1462-72.
2011: Tom Henkens; Sarah Snykers; Mathieu Vinken; Joanna Fraczek; Aneta Lukaszuk; Dirk Tourwé; Geert Verheyen; Jacky Van Gompel; Philippe Vanparys; Vera Rogiers; Tamara Vanhaecke
Preservation of hepatocellular functionality in cultures of primary rat hepatocytes upon exposure to 4-Me2N-BAVAH, a hydroxamate-based HDAC-inhibitor.
Toxicology in vitro : an international journal published in association with BIBRA 2011;25(1):100-9.
2010: Thomas L Mindt; Harriet Struthers; Bernhard Spingler; Luc Brans; Dirk Tourwé; Elisa García-Garayoa; Roger Schibli
Molecular assembly of multifunctional ⁹⁹(m)Tc radiopharmaceuticals using "clickable" amino acid derivatives.
ChemMedChem 2010;5(12):2026-38.
2010: T Duchène; C Mihai; Rudolph Willem; Dirk Tourwé
Monitoring the allyl ester deprotection by HR MAS NMR in BAL-solid phase peptide synthesis.
Journal of peptide science : an official publication of the European Peptide Society 2010;16(12):679-86.
2010: Luc Brans; Elisa García-Garayoa; Christian Schweinsberg; Veronique Maes; Harriet Struthers; Roger Schibli; Dirk Tourwé
Synthesis and evaluation of bombesin analogues conjugated to two different triazolyl-derived chelators for (99m)Tc labeling.
ChemMedChem 2010;5(10):1717-25.
2010: Steven Ballet; Ewa D Marczak; Debby Feytens; Severo Salvadori; Yusuke Sasaki; Andrew D Abell; Lawrence H Lazarus; Gianfranco Balboni; Dirk Tourwé
Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.
Bioorganic & medicinal chemistry letters 2010;20(5):1610-3.
2010: Karolina Pulka; Debby Feytens; Aleksandra Misicka; Dirk Tourwé
New tetracyclic tetrahydro-beta-carbolines as tryptophan-derived peptidomimetics.
Molecular diversity 2010;14(1):97-108.
2010: Stijn Claerhout; Thibault Duchène; Dirk Tourwé; Erik Van Der Eycken
Development of a new microwave-assisted cleavable backbone amide linker (BAL): a comparative study.
Organic & biomolecular chemistry 2010;8(1):60-5.
2010: Patrycja Kleczkowska; Piotr Kosson; Steven Ballet; Isabelle Van den Eynde; Yuko Tsuda; Dirk Tourwé; Andrzej W Lipkowski
PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects.
Molecular pain 2010;6():86.
2009: Heidi Demaegdt; Aneta Lukaszuk; Evi De Buyser; Jean-Paul De Backer; Erzsébet Szemenyei; Géza Tóth; Sridhara Chakravarthy; Mitradas Panicker; Yvette Michotte; Dirk Tourwé; Georges Vauquelin
Selective labeling of IRAP by the tritiated AT(4) receptor ligand [3H]Angiotensin IV and its stable analog [3H]AL-11.
Molecular and cellular endocrinology 2009;311(1-2):77-86.
2009: Aneta Lukaszuk; Heidi Demaegdt; Debby Feytens; Patrick M L Vanderheyden; Georges Vauquelin; Dirk Tourwé
The replacement of His(4) in angiotensin IV by conformationally constrained residues provides highly potent and selective analogues.
Journal of medicinal chemistry 2009;52(18):5612-8.
2009: Faisal Alshoukr; Cedric Rosant; Veronique Maes; Jallane Abdelhak; Olivier Raguin; Samuel Burg; Laure Sarda; Jacques Barbet; Dirk Tourwé; Didier Pelaprat; Anne Gruaz-Guyon
Novel neurotensin analogues for radioisotope targeting to neurotensin receptor-positive tumors.
Bioconjugate chemistry 2009;20(8):1602-10.
2009: Joanna Fraczek; Sarah Deleu; Aneta Lukaszuk; Tatyana Doktorova; Dirk Tourwé; Albert Geerts; Tamara Vanhaecke; Karin Vanderkerken; Vera Rogiers
Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors.
Investigational new drugs 2009;27(4):338-46.
2009: Thomas L Mindt; Christian Schweinsberg; Luc Brans; Adelheid Hagenbach; Ulrich Abram; Dirk Tourwé; Elisa Garcia-Garayoa; Roger Schibli
A click approach to structurally diverse conjugates containing a central di-1,2,3-triazole metal chelate.
ChemMedChem 2009;4(4):529-39.
2009: Steven Ballet; Debby Feytens; Rien De Wachter; Magali De Vlaeminck; Ewa D Marczak; Severo Salvadori; Chris de Graaf; Didier Rognan; Lucia Negri; Roberta Lattanzi; Lawrence H Lazarus; Dirk Tourwé; Gianfranco Balboni
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.
Bioorganic & medicinal chemistry letters 2009;19(2):433-7.
2009: Debby Feytens; Magali De Vlaeminck; Renzo Cescato; Dirk Tourwé; Jean Claude Reubi
Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities.
Journal of medicinal chemistry 2009;52(1):95-104.
2009: Veronique Maes; Luc Brans; Christian Schweinsberg; Elisa Garcia-Garayoa; Peter Bläuenstein; P August Schubiger; Dirk Tourwé
Carbohydrated [99mTc(CO)3](NalphaHis)Ac-bombesin(7-14) analogs.
Advances in experimental medicine and biology 2009;611():409-10.
2009: Elisa García-Garayoa; Peter Bläuenstein; Alain Blanc; Veronique Maes; Dirk Tourwé; P August Schubiger
A stable neurotensin-based radiopharmaceutical for targeted imaging and therapy of neurotensin receptor-positive tumours.
European journal of nuclear medicine and molecular imaging 2009;36(1):37-47.
2008: Christian Schweinsberg; Veronique Maes; Luc Brans; Peter Bläuenstein; Dirk Tourwé; P August Schubiger; Roger Schibli; Elisa García-Garayoa
Novel glycated [99mTc(CO)3]-labeled bombesin analogues for improved targeting of gastrin-releasing peptide receptor-positive tumors.
Bioconjugate chemistry 2008;19(12):2432-9.
2008: Steven Ballet; Aleksandra Misicka; Piotr Kosson; Carole Lemieux; Nga N Chung; Peter W Schiller; Andrzej W Lipkowski; Dirk Tourwé
Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.
Journal of medicinal chemistry 2008;51(8):2571-4.
2008: Tom Henkens; Mathieu Vinken; Aneta Lukaszuk; Dirk Tourwé; Tamara Vanhaecke; Vera Rogiers
Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes.
Toxicology letters 2008;178(1):37-43.
2008: Aneta Lukaszuk; Heidi Demaegdt; Erzsebet Szemenyei; Géza Tóth; Dagmara Tymecka; Aleksandra Misicka; Philippe Karoyan; Patrick M L Vanderheyden; Georges Vauquelin; Dirk Tourwé
Beta-homo-amino acid scan of angiotensin IV.
Journal of medicinal chemistry 2008;51(7):2291-6.
2008: Csaba Tömböly; Steven Ballet; Debby Feytens; Katalin E Kövér; Attila Borics; Sandor Lovas; Mahmoud Al-Khrasani; Zsuzsanna Fürst; Géza Tóth; Sándor Benyhe; Dirk Tourwé
Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.
Journal of medicinal chemistry 2008;51(1):173-7.
2007: Peggy Papeleu; Andy Wullaert; Greetje Elaut; Tom Henkens; Mathieu Vinken; Georges Laus; Dirk Tourwé; Rudi Beyaert; Vera Rogiers; Tamara Vanhaecke
Inhibition of NF-kappaB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes.
Cell proliferation 2007;40(5):640-55.
2007: Eniko Ioja; Dirk Tourwé; István Kertész; Géza Tóth; Anna Borsodi; Sándor Benyhe
Novel diastereomeric opioid tetrapeptides exhibit differing pharmacological activity profiles.
Brain research bulletin 2007;74(1-3):119-29.
2007: István Ilisz; Steven Ballet; Karolien Van Rompaey; Rien De Wachter; Dirk Tourwé; Daniel W Armstrong; Antal Péter
High-performance liquid chromatographic separation of stereoisomers of N-phthaloyl-protected amino acids and dipeptidomimetics.
Journal of separation science 2007;30(12):1881-7.
2007: Debby Feytens; Renzo Cescato; Jean Claude Reubi; Dirk Tourwé
New sst4/5-selective somatostatin peptidomimetics based on a constrained tryptophan scaffold.
Journal of medicinal chemistry 2007;50(14):3397-401.
2007: Mathieu Vinken; Tom Henkens; Sarah Snykers; Aneta Lukaszuk; Dirk Tourwé; Vera Rogiers; Tamara Vanhaecke
The novel histone deacetylase inhibitor 4-Me2N-BAVAH differentially affects cell junctions between primary hepatocytes.
Toxicology 2007;236(1-2):92-102.
2007: Steven Ballet; Alexander V Mayorov; Minying Cai; Dagmara Tymecka; Kevin B Chandler; Erin S Palmer; Karolien Van Rompaey; Aleksandra Misicka; Dirk Tourwé; Victor J Hruby
Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold.
Bioorganic & medicinal chemistry letters 2007;17(9):2492-8.
2007: Greetje Elaut; Georges Laus; Eliane Alexandre; L Richert; P Bachellier; Dirk Tourwé; Vera Rogiers; Tamara Vanhaecke
A metabolic screening study of trichostatin A (TSA) and TSA-like histone deacetylase inhibitors in rat and human primary hepatocyte cultures.
The Journal of pharmacology and experimental therapeutics 2007;321(1):400-8.
2007: Elisa García-Garayoa; C Schweinsberg; Veronique Maes; Dominique Rüegg; Alain Blanc; Peter Bläuenstein; Dirk Tourwé; Annette G Beck-Sickinger; P August Schubiger
New [99mTc]bombesin analogues with improved biodistribution for targeting gastrin releasing-peptide receptor-positive tumors.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology 2007;51(1):42-50.
2007: Steven Ballet; R De Wachter; Karolien Van Rompaey; Csaba Tömböly; D Feytens; G Töth; Laura Quartara; Paola Cucchi; stefania meini; Dirk Tourwé
Bradykinin analogs containing the 4-amino-2-benzazepin-3-one scaffold at the C-terminus.
Journal of peptide science : an official publication of the European Peptide Society 2007;13(3):164-70.
2007: Géza Tóth; Eniko Ioja; Csaba Tömböly; Steven Ballet; Dirk Tourwé; Antal Péter; Tamás Martinek; Nga N Chung; Peter W Schiller; Sándor Benyhe; Anna Borsodi
Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists.
Journal of medicinal chemistry 2007;50(2):328-33.
2007: Elisa García-Garayoa; Dominique Rüegg; Peter Bläuenstein; Martin Zwimpfer; Irfan Ullah Khan; Veronique Maes; Alain Blanc; Annette G Beck-Sickinger; Dirk Tourwé; P August Schubiger
Chemical and biological characterization of new Re(CO)3/[99mTc](CO)3 bombesin analogues.
Nuclear medicine and biology 2007;34(1):17-28.
2006: Thomas L Mindt; Harriet Struthers; Luc Brans; Todor Anguelov; Christian Schweinsberg; Veronique Maes; Dirk Tourwé; Roger Schibli
"Click to chelate": synthesis and installation of metal chelates into biomolecules in a single step.
Journal of the American Chemical Society 2006;128(47):15096-7.
2006: Veronique Maes; Christina Hultsch; Suzann Kohl; Ralf Bergmann; Thomas Hanke; Dirk Tourwé
Fluorescein-labeled stable neurotensin derivatives.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(8):505-8.
2006: István Ilisz; Dirk Tourwé; Daniel W Armstrong; Antal Péter
High-performance liquid chromatographic enantioseparation of unusual secondary amino acids on a D-penicillamine-based chiral ligand exchange column.
Chirality 2006;18(7):539-43.
2006: Berthold A Nock; Anastasia Nikolopoulou; Jean Claude Reubi; Veronique Maes; Peter Conrath; Dirk Tourwé; Theodosia Maina
Toward stable N4-modified neurotensins for NTS1-receptor-targeted tumor imaging with 99mTc.
Journal of medicinal chemistry 2006;49(15):4767-76.
2006: Steven Ballet; Severo Salvadori; Claudio Trapella; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Lucia Negri; Elisa Giannini; Roberta Lattanzi; Dirk Tourwé; Gianfranco Balboni
New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Journal of medicinal chemistry 2006;49(13):3990-3.
2006: Elisa García-Garayoa; Veronique Maes; Peter Bläuenstein; Alain Blanc; Alexander Hohn; Dirk Tourwé; P August Schubiger
Double-stabilized neurotensin analogues as potential radiopharmaceuticals for NTR-positive tumors.
Nuclear medicine and biology 2006;33(4):495-503.
2006: Paolo Ruzza; Luca Cesaro; Dirk Tourwé; Andrea Calderan; Barbara Biondi; Veronique Maes; Ileana Menegazzo; Alessio Osler; Chiara Rubini; Andrea Guiotto; Lorenzo A Pinna; Gianfranco Borin; Arianna Donella-Deana
Spatial conformation and topography of the tyrosine aromatic ring in substrate recognition by protein tyrosine kinases.
Journal of medicinal chemistry 2006;49(6):1916-24.
2006: Veronique Maes; Elisa Garcia-Garayoa; Peter Bläuenstein; Dirk Tourwé
Novel 99mTc-labeled neurotensin analogues with optimized biodistribution properties.
Journal of medicinal chemistry 2006;49(5):1833-6.
2005: Steven Ballet; A Frycia; J Piron; Nga N Chung; Peter W Schiller; Piotr Kosson; Andrzej W Lipkowski; Dirk Tourwé
Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using the 4-amino-2-benzazepin-3-one scaffold.
The journal of peptide research : official journal of the American Peptide Society 2005;66(5):222-30.
2005: Kenno Vanommeslaeghe; Stefan Loverix; Paul Geerlings; Dirk Tourwé
DFT-based ranking of zinc-binding groups in histone deacetylase inhibitors.
Bioorganic & medicinal chemistry 2005;13(21):6070-82.
2005: Kenno Vanommeslaeghe; Frank De Proft; Stefan Loverix; Dirk Tourwé; Paul Geerlings
Theoretical study revealing the functioning of a novel combination of catalytic motifs in histone deacetylase.
Bioorganic & medicinal chemistry 2005;13(12):3987-92.
2005: Isabelle Van den Eynde; Georges Laus; Peter W Schiller; Piotr Kosson; Nga N Chung; Andrzej W Lipkowski; Dirk Tourwé
A new structural motif for mu-opioid antagonists.
Journal of medicinal chemistry 2005;48(10):3644-8.
2004: Isabelle Van den Eynde; Karolien Van Rompaey; Francesco Lazzaro; Dirk Tourwé
Solid-supported solution-phase synthesis of 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones.
Journal of combinatorial chemistry 2004;6(4):468-73.
2004: Greetje Elaut; Georges Laus; Peggy Papeleu; Gabriëlla Török; Dirk Tourwé; Tamara Vanhaecke; Vera Rogiers
Rat hepatocyte suspensions as a suitable in vitro model for studying the biotransformation of histone deacetylase inhibitors.
Alternatives to laboratory animals : ATLA 2004;32 Suppl 1A():105-12.
2004: Peter Bläuenstein; Elisa García Garayoa; Dominique Rüegg; Alain Blanc; Dirk Tourwé; Annette G Beck-Sickinger; P August Schubiger
Improving the tumor uptake of 99mTc-labeled neuropeptides using stabilized peptide analogues.
Cancer biotherapy & radiopharmaceuticals 2004;19(2):181-8.
2004: Antal Péter; Anita Arki; Erika Vékes; Dirk Tourwé; László Lázár; Ferenc FüLöp; Daniel W Armstrong
Direct and indirect high-performance liquid chromatographic enantioseparation of beta-amino acids.
Journal of chromatography. A 2004;1031(1-2):171-8.
2004: Antal Péter; Anita Arki; Dirk Tourwé; Eniko Forró; Ferenc FüLöp; Daniel W Armstrong
Comparison of the separation efficiencies of chirobiotic T and TAG columns in the separation of unusual amino acids.
Journal of chromatography. A 2004;1031(1-2):159-70.
2004: Sylvia Van Cauwenberghe; Frédéric Simonin; Jérôme Cluzeau; Jerome Becker; William D Lubell; Dirk Tourwé
Structure-activity study of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH2.
Journal of medicinal chemistry 2004;47(7):1864-7.
2004: Csaba Tömböly; Katalin E Kövér; Antal Péter; Dirk Tourwé; Dauren Biyashev; Sándor Benyhe; Anna Borsodi; Mahmoud Al-Khrasani; András Z Rónai; Géza Tóth
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.
Journal of medicinal chemistry 2004;47(3):735-43.
2003: Franz Buchegger; Florent Bonvin; Marek Kosinski; Andreas O Schaffland; John Prior; Jean C Reubi; Peter Bläuenstein; Dirk Tourwé; Elisa García-Garayoa; Angelika Bischof Delaloye
Radiolabeled neurotensin analog, 99mTc-NT-XI, evaluated in ductal pancreatic adenocarcinoma patients.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(10):1649-54.
2003: Kenno Vanommeslaeghe; Christian Van Alsenoy; Frank De Proft; José C Martins; Dirk Tourwé; Paul Geerlings
Ab initio study of the binding of Trichostatin A (TSA) in the active site of histone deacetylase like protein (HDLP).
Organic & biomolecular chemistry 2003;1(16):2951-7.
2003: K Van Ommeslaeghe; Greetje Elaut; V Brecx; Peggy Papeleu; Koen Iterbeke; P Geerlings; Dirk Tourwé; Vera Rogiers
Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition.
Bioorganic & medicinal chemistry letters 2003;13(11):1861-4.
2002: Liliane Halab; Jerome Becker; Zsuzsanna Darula; Dirk Tourwé; Brigitte L Kieffer; Frédéric Simonin; William D Lubell
Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.
Journal of medicinal chemistry 2002;45(24):5353-7.
2002: Roberto La Bella; Elisa Garcia-Garayoa; M Bahler; Peter Bläuenstein; Roger Schibli; Peter Conrath; Dirk Tourwé; P August Schubiger
A 99mTc(I)-postlabeled high affinity bombesin analogue as a potential tumor imaging agent.
Bioconjugate chemistry 2002;13(3):599-604.
2002: Zsolt Szakonyi; Ferenc FüLöp; Dirk Tourwé; Norbert De Kimpe
Synthesis of 1,2,7,7a-tetrahydro-1aH-cyclopropa[b]quinoline-1a-carboxylic acid derivatives, doubly constrained ACC derivatives, by a remarkable cyclopropanation process.
The Journal of organic chemistry 2002;67(7):2192-6.
2002: Matthias Bruehlmeier; Elisa García Garayoa; Alain Blanc; Barbara Holzer; Suzanne Gergely; Dirk Tourwé; P August Schubiger; Peter Bläuenstein
Stabilization of neurotensin analogues: effect on peptide catabolism, biodistribution and tumor binding.
Nuclear medicine and biology 2002;29(3):321-7.
2002: Erika Vékes; Gabriella Török; Antal Péter; János Sapi; Dirk Tourwé
Indirect high-performance liquid chromatographic separation of stereoisomers of beta-alkyl-substituted amino acids by the application of (S)-N-(4-nitrophenoxycarbonyl)phenylalanine methoxyethyl ester as chiral derivatizing agent.
Journal of chromatography. A 2002;949(1-2):125-39.
2002: Antal Péter; Erika Vékes; Géza Tóth; Dirk Tourwé; Frans Borremans
Application of a new chiral derivatizing agent to the enantioseparation of secondary amino acids.
Journal of chromatography. A 2002;948(1-2):283-94.
2002: Elisa García-Garayoa; Peter Bläuenstein; Matthias Bruehlmeier; Alain Blanc; Koen Iterbeke; Peter Conrath; Dirk Tourwé; P August Schubiger
Preclinical evaluation of a new, stabilized neurotensin(8--13) pseudopeptide radiolabeled with (99m)tc.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(3):374-83.
2002: Ralf Bergmann; Matthias Scheunemann; Christoph Heichert; Peter Mäding; Holm Wittrisch; Marion Kretzschmar; Heike Rodig; Dirk Tourwé; Koen Iterbeke; Kris Chavatte; Daniel Zips; Jean Claude Reubi; Bernd Johannsen
Biodistribution and catabolism of (18)F-labeled neurotensin(8-13) analogs.
Nuclear medicine and biology 2002;29(1):61-72.
2001: José C Martins; Karolien Van Rompaey; G Wittmann; Csaba Tömböly; G Tóth; Norbert De Kimpe; Dirk Tourwé
Unprecedented sigmatropic rearrangements leading to 2,3-dihydro-1h-2-benzazepine-3-carboxylic acid.
The Journal of organic chemistry 2001;66(8):2884-6.
2001: Frédéric Gosselin; Dirk Tourwé; M Ceusters; T Meert; Lieve I Heylen; Mirek Jurzak; William D Lubell
Probing opioid receptor-ligand interactions by employment of indolizidin-9-one amino acid as a constrained Gly(2)-Gly(3) surrogate in a leucine-enkephalin mimic.
The journal of peptide research : official journal of the American Peptide Society 2001;57(4):337-44.
2001: Elisa García-Garayoa; L Allemann-Tannahill; Peter Bläuenstein; M Willmann; N Carrel-Rémy; Dirk Tourwé; Koen Iterbeke; Peter Conrath; P August Schubiger
In vitro and in vivo evaluation of new radiolabeled neurotensin(8-13) analogues with high affinity for NT1 receptors.
Nuclear medicine and biology 2001;28(1):75-84.
2000: Antal Péter; Gabriella Török; Daniel W Armstrong; Gábor Tóth; Dirk Tourwé
High-performance liquid chromatographic separation of enantiomers of synthetic amino acids on a ristocetin A chiral stationary phase.
Journal of chromatography. A 2000;904(1):1-15.
2000: Richard Casimir; Koen Iterbeke; W Van Den Nest; Marie-Claude Trescol-Biémont; H Dumortier; S Muller; Denis Gerlier; Chantal Rabourdin-Combe; Dirk Tourwé; J Paris
Conformational restriction of the Tyr53 side-chain in the decapeptide HE.
The journal of peptide research : official journal of the American Peptide Society 2000;56(6):398-408.
2000: Richard Casimir; Dirk Tourwé; Koen Iterbeke; Gilles Guichard; Jean-Paul Briand
Efficient synthesis of (S)-4-phthalimido-1,3,4,5-tetrahydro-8-(2,6-dichlorobenzyloxy)- 3-oxo-2H-2-benzazepin-2-acetic acid (PHt-Hba(2,6-Cl2-Bn)-Gly-OH).
The Journal of organic chemistry 2000;65(20):6487-92.
2000: J Czombos; W Aelterman; A Tkachev; José C Martins; Dirk Tourwé; Antal Péter; G Tóth; Ferenc FüLöp; Norbert De Kimpe
Convenient synthesis of 3,4-methano-1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acid and its derivatives as doubly constrained nonproteinogenic amino acid derivatives.
The Journal of organic chemistry 2000;65(18):5469-75.
2000: Zsuzsanna Darula; Katalin E Kövér; Krisztina Monory; Anna Borsodi; Ernõ Makó; András Z Rónai; Dirk Tourwé; Antal Péter; Gábor Tóth
Deltorphin II analogues with 6-hydroxy-2-aminotetralin-2-carboxylic acid in position 1.
Journal of medicinal chemistry 2000;43(7):1359-66.
2000: Antal Péter; E Olajos; Richard Casimir; Dirk Tourwé; Q B Broxterman; B Kaptein; Daniel W Armstrong
High-performance liquid chromatographic separation of the enantiomers of unusual alpha-amino acid analogues.
Journal of chromatography. A 2000;871(1-2):105-13.
1999: André Egli; Roger Alberto; L Tannahill; Roger Schibli; Ulrich Abram; Andreas O Schaffland; Robert Waibel; Dirk Tourwé; L Jeannin; Koen Iterbeke; P August Schubiger
Organometallic 99mTc-aquaion labels peptide to an unprecedented high specific activity.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(11):1913-7.
1999: P August Schubiger; L Allemann-Tannahill; André Egli; Roger Schibli; Roger Alberto; N Carrel-Rémy; M Willmann; Peter Bläuenstein; Dirk Tourwé
Catabolism of neurotensins. Implications for the design of radiolabeling strategies of peptides.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1999;43(2):155-8.
1998: Antal Péter; Gabriella Török; Daniel W Armstrong; Gábor Tóth; Dirk Tourwé
Effect of temperature on retention of enantiomers of beta-methyl amino acids on a teicoplanin chiral stationary phase.
Journal of chromatography. A 1998;828(1-2):177-90.
1998: Dirk Tourwé; E Mannekens; T N Diem; P Verheyden; H Jaspers; G Tóth; Antal Péter; István Kertész; Gabriella Török; Nga N Chung; Peter W Schiller
Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile.
Journal of medicinal chemistry 1998;41(26):5167-76.
1997: G Tóth; Zsuzsanna Darula; Antal Péter; F Fülöp; Dirk Tourwé; H Jaspers; P Verheyden; Z Böcskey; Z Tóth; Anna Borsodi
Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3.
Journal of medicinal chemistry 1997;40(6):990-5.
1996: Antal Péter; S Devadder; G Laus; Dirk Tourwé
Liquid chromatography studies on the enzymatic degradation of luteinizing hormone-releasing hormone analogues with off-line identification by mass spectrometry.
Journal of chromatography. A 1996;729(1-2):137-42.
1996: Antal Péter; G Tóth; Gabriella Török; Dirk Tourwé
Separation of enantiomeric beta-methyl amino acids and of beta-methyl amino acid containing peptides.
Journal of chromatography. A 1996;728(1-2):455-65.
1996: Dirk Tourwé; K Verschueren; A Frycia; P Davis; F Porreca; V J Hruby; G Toth; H Jaspers; P Verheyden; G Van Binst
Conformational restriction of Tyr and Phe side chains in opioid peptides: information about preferred and bioactive side-chain topology.
Biopolymers 1996;38(1):1-12.
1995: Antal Péter; G Tóth; E Olajos; Dirk Tourwé
Chromatographic behaviour of opioid peptides containing beta-methylphenylalanine isomers.
Journal of chromatography. A 1995;705(2):267-73.
1993: J Couder; Dirk Tourwé; G Van Binst; J Schuurkens; J E Leysen
Synthesis and biological activities of psi (CH2NH) pseudopeptide analogues of the C-terminal hexapeptide of neurotensin.
International journal of peptide and protein research 1993;41(2):181-4.
1993: Antal Péter; G Laus; Dirk Tourwé; E Gerlo; G Van Binst
An evaluation of microwave heating for the rapid hydrolysis of peptide samples for chiral amino acid analysis.
Peptide research 1993;6(1):48-52.
1993: N G Delaet; P Verheyden; B Velkeniers; E L Hooghe-Peters; C Bruns; Dirk Tourwé; G Van Binst
Synthesis, biological activity and conformational study of a somatostatin hexapeptide analogue containing a reduced peptide bond.
Peptide research 1993;6(1):24-30.
1992: H Jaspers; Dirk Tourwé; G van Binst; H Pepermans; P Borea; L Ucelli; S Salvadori
Dermorphin tetra- and heptapeptide analogues containing a [3,4] amide bond replacement by a carbon-carbon double and single bond.
International journal of peptide and protein research 1992;39(4):315-21.
1992: Dirk Tourwé; J Couder; M Ceusters; D Meert; T F Burks; T H Kramer; P Davis; R Knapp; Henry I Yamamura; J E Leysen
Synthesis and biological activities of linear and cyclic enkephalin analogues containing a psi (E,CH = CH) or psi (CH2CH2) isosteric replacement.
International journal of peptide and protein research 1992;39(2):131-6.
1992: G Van Binst; Dirk Tourwé
Backbone modifications in somatostatin analogues: relation between conformation and activity.
Peptide research 1992;5(1):8-13.
1991: N G Delaet; P M Verheyden; Dirk Tourwé; G Van Binst
Assignment of the 1H-NMR resonances of the four rotamers of beta-casomorphin-5 in DMSO.
Biopolymers 1991;31(12):1409-16.
1989: Claudio Toniolo; G Valle; Marco Crisma; J S Kaltenbronn; J T Repine; G Van Binst; M Elseviers; Dirk Tourwé
Psi [CH2NH] backbone-modified peptides: first unequivocal observation of a C7 structure in a linear peptide.
Peptide research 1989;2(5):332-7.
1988: M Elseviers; L Van der Auwera; H Pepermans; Dirk Tourwé; G Van Binst
Evidence for the bioactive conformation in a cyclic hexapeptide analogue of somatostatin containing a cis-peptide bond mimic.
Biochemical and biophysical research communications 1988;154(2):515-21.
1988: M De Bondt; J Couder; L Van der Auwera; M Van Marsenille; M Elseviers; N Delaet; G Laus; Dirk Tourwé; G van Binst
Determination of the chiral purity of dipeptide isosteres containing a reduced peptide bond by gas chromatographic analysis.
Journal of chromatography 1988;442():165-73.
1988: H Pepermans; Dirk Tourwé; G Van Binst; R Boelens; R M Scheek; W F Van Gunsteren; R Kaptein
The combined use of NMR, distance geometry, and restrained molecular dynamics for the conformational study of a cyclic somatostatin analogue.
Biopolymers 1988;27(2):323-38.
1987: Michal Lebl; E E Sugg; G van Binst; P Vander Elst; Dirk Tourwé; Jirina Slaninová; Victor J Hruby
Analogs of oxytocin containing a modified peptide bond.
International journal of peptide and protein research 1987;30(3):318-22.
1987: P Vander Elst; D Gondol; C Wynants; Dirk Tourwé; G van Binst
Synthesis and conformational study of two cyclic analogues of somatostatin containing an AMPA-spacer unit.
International journal of peptide and protein research 1987;29(3):331-46.
1986: P Vander Elst; M Elseviers; E De Cock; M Van Marsenille; Dirk Tourwé; G Van Binst
Synthesis and conformational study of two L-prolyl-L-leucyl-glycinamide analogues with a reduced peptide bond.
International journal of peptide and protein research 1986;27(6):633-42.
1984: Dirk Tourwé; J L De Coen; K Hallenga; G Van Binst
Conformational properties of the pentapeptide fragment [32-36] of the thymic hormone thymopoietin.
International journal of peptide and protein research 1984;23(1):84-93.