Rhian Touyz

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Fu Accalia; Ng Andy Cheuk-Him; Depatie Chantal; Wijesekara Nadeeja; He Ying; Wang Gen-Sheng; Bardeesy Nabeel; Scott Fraser W; Touyz Rhian M; Wheeler Michael B; Screaton Robert A
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.
Xu Shaoping; He Ying; Vokurkova Martina; Touyz Rhian M
Endothelial cells negatively modulate reactive oxygen species generation in vascular smooth muscle cells: role of thioredoxin.
Gava Elisandra; Samad-Zadeh Arman; Zimpelmann Joseph; Bahramifarid Nasim; Kitten Gregory T; Santos Robson A; Touyz Rhian M; Burns Kevin D
Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells.

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All Publications

2009: Fu Accalia; Ng Andy Cheuk-Him; Depatie Chantal; Wijesekara Nadeeja; He Ying; Wang Gen-Sheng; Bardeesy Nabeel; Scott Fraser W; Touyz Rhian M; Wheeler Michael B; Screaton Robert A
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.
Cell metabolism 2009;10(4):285-95.
2009: Xu Shaoping; He Ying; Vokurkova Martina; Touyz Rhian M
Endothelial cells negatively modulate reactive oxygen species generation in vascular smooth muscle cells: role of thioredoxin.
Hypertension 2009;54(2):427-33.
2009: Gava Elisandra; Samad-Zadeh Arman; Zimpelmann Joseph; Bahramifarid Nasim; Kitten Gregory T; Santos Robson A; Touyz Rhian M; Burns Kevin D
Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(6):1766-73.
2009: Sedeek Mona; Hébert Richard L; Kennedy Chris R; Burns Kevin D; Touyz Rhian M
Molecular mechanisms of hypertension: role of Nox family NADPH oxidases.
Current opinion in nephrology and hypertension 2009;18(2):122-7.
2009: Paravicini Tamara M; Yogi Alvaro; Mazur Andrzej; Touyz Rhian M
Dysregulation of vascular TRPM7 and annexin-1 is associated with endothelial dysfunction in inherited hypomagnesemia.
Hypertension 2009;53(2):423-9.
2009: Touyz Rhian M; Montezano Augusto C
Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification.
Cardiovascular research 2009;81(2):237-9.
2009: Yogi Alvaro; Callera Glaucia E; Tostes Rita; Touyz Rhian M
Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;296(2):R201-7.
2009: Callera Glaucia E; He Ying; Yogi Alvaro; Montezano Augusto C; Paravicini Tamara; Yao Guoying; Touyz Rhian M
Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells.
Journal of hypertension 2009;27(1):155-66.
2009: Touyz Rhian M; Callera Glaucia E
A new look at the eye: aldosterone and mineralocorticoid receptors as novel targets in retinal vasculopathy.
Circulation research 2009;104(1):9-11.
2008: Park Young Mee; Lim Bong Hee; Touyz Rhian M; Park Jeong Bae
Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat.
Journal of Korean medical science 2008;23(6):1039-45.
2008: Montezano Augusto C; Touyz Rhian M
Networking between systemic angiotensin II and cardiac mineralocorticoid receptors.
Hypertension 2008;52(6):1016-8.
2008: Yzydorczyk Catherine; Comte Blandine; Cambonie Gilles; Lavoie Jean-Claude; Germain Nathalie; Ting Shun Yue; Wolff Julie; Deschepper Christian; Touyz Rhian M; Lelièvre-Pegorier Martine; Nuyt Anne Monique
Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood.
Hypertension 2008;52(5):889-95.
2008: Mercure Chantal; Yogi Alvaro; Callera Glaucia E; Aranha Anna B; Bader Michael; Ferreira Anderson J; Santos Robson A S; Walther Thomas; Touyz Rhian M; Reudelhuber Timothy L
Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart.
Circulation research 2008;103(11):1319-26.
2008: Ebrahimian Talin; Sairam M Ram; Schiffrin Ernesto L; Touyz Rhian M
Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1481-8.
2008: Montezano A C; Callera G E; Yogi A; He Y; Tostes R C; He G; Schiffrin E L; Touyz R M
Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(8):1511-8.
2008: de Denus Simon; Zakrzewski-Jakubiak Marcin; Dubé Marie-Pierre; Bélanger François; Lepage Serge; Leblanc Marie-Hélène; Gossard Denis; Ducharme Anique; Racine Normand; Whittom Lucette; Lavoie Joel; Touyz Rhian M; Turgeon Jacques; White Michel
Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan.
The Annals of pharmacotherapy 2008;42(7):925-32.
2008: Tabet Fatiha; Schiffrin Ernesto L; Callera Glaucia E; He Ying; Yao Guoying; Ostman Arne; Kappert Kai; Tonks Nicholas K; Touyz Rhian M
Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR.
Circulation research 2008;103(2):149-58.
2008: Viel Emilie C; Benkirane Karim; Javeshghani Danesh; Touyz Rhian M; Schiffrin Ernesto L
Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H281-8.
2008: Padwal Raj J; Hemmelgarn Brenda R; Khan Nadia A; Grover Steven; McAlister Finlay A; McKay Donald W; Wilson Thomas; Penner Brian; Burgess Ellen; Bolli Peter; Hill Michael D; Mahon Jeff; Myers Martin G; Abbott Carl; Schiffrin Ernesto L; Honos George; Mann Karen; Tremblay Guy; Milot Alain; Cloutier Lyne; Chockalingam Arun; Rabkin Simon W; Dawes Martin Dawes; Touyz Rhian M; Bell Chaim; Burns Kevin D; Ruzicka Marcel; Campbell Norman R C; Lebel Marcel; Tobe Sheldon W;
The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 - blood pressure measurement, diagnosis and assessment of risk.
The Canadian journal of cardiology 2008;24(6):455-63.
2008: Touyz Rhian M; Schiffrin Ernesto L
Reactive oxygen species and hypertension: a complex association.
Antioxidants & redox signaling 2008;10(6):1041-4.
2008: Ebrahimian Talin; Touyz Rhian M
Thioredoxin in vascular biology: role in hypertension.
Antioxidants & redox signaling 2008;10(6):1127-36.
2008: Sontia Bruno; Montezano Augusto C I; Paravicini Tamara; Tabet Fatiha; Touyz Rhian M
Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium.
Hypertension 2008;51(4):915-21.
2008: Touyz Rhian M
Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1103-18.
2008: Sontia Bruno; Mooney Jan; Gaudet Lise; Touyz Rhian M
Pseudohyperaldosteronism, liquorice, and hypertension.
Journal of clinical hypertension (Greenwich, Conn.) 2008;10(2):153-7.
2008: Paravicini Tamara M; Touyz Rhian M
NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities.
Diabetes care 2008;31 Suppl 2():S170-80.
2008: Yogi Alvaro; Mercure Chantal; Touyz Joshuah; Callera Glaucia E; Montezano Augusto C I; Aranha Anna B; Tostes Rita C; Reudelhuber Timothy; Touyz Rhian M
Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension.
Hypertension 2008;51(2):500-6.
2008: Savoia Carmine; Touyz Rhian M; Amiri Farhad; Schiffrin Ernesto L
Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients.
Hypertension 2008;51(2):432-9.
2008: Touyz Rhian M
Apocynin, NADPH oxidase, and vascular cells: a complex matter.
Hypertension 2008;51(2):172-4.
2008: Tostes Rita C; Fortes Zuleica B; Callera Glaucia E; Montezano Augusto C; Touyz Rhian M; Webb R Clinton; Carvalho Maria Helena C
Endothelin, sex and hypertension.
Clinical science (London, England : 1979) 2008;114(2):85-97.
2007: Sontia Bruno; Touyz Rhian M
Magnesium transport in hypertension.
Pathophysiology : the official journal of the International Society for Pathophysiology / ISP 2007;14(3-4):205-11.
2007: Sampaio Walkyria O; Henrique de Castro Carlos; Santos Robson A S; Schiffrin Ernesto L; Touyz Rhian M
Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells.
Hypertension 2007;50(6):1093-8.
2007: Graham Delyth; McBride Martin W; Gaasenbeek Michelle; Gilday Kirsten; Beattie Elisabeth; Miller William H; McClure John D; Polke James M; Montezano Augusto; Touyz Rhian M; Dominiczak Anna F
Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat: congenic analysis.
Hypertension 2007;50(6):1134-41.
2007: Zargham Ramin; Touyz Rhian M; Thibault Gaétan
alpha 8 Integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype.
Atherosclerosis 2007;195(2):303-12.
2007: Touyz Rhian M
Vascular remodeling, retinal arteries, and hypertension.
Hypertension 2007;50(4):603-4.
2007: da Costa Gonçalves Andrey C; Leite Romulo; Fraga-Silva Rodrigo A; Pinheiro Sergio V; Reis Augusto B; Reis Fernando M; Touyz Rhian M; Webb R Clinton; Alenina Natalia; Bader Michael; Santos Robson A S
Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function.
American journal of physiology. Heart and circulatory physiology 2007;293(4):H2588-96.
2007: Fox Chester H; Timm Earl A; Smith Susan J; Touyz Rhian M; Bush Eric G; Wallace Paul K
A method for measuring intracellular free magnesium concentration in platelets using flow cytometry.
Magnesium research : official organ of the International Society for the Development of Research on Magnesium 2007;20(3):200-7.
2007: Yogi A; Callera G E; Montezano A C I; Aranha A B; Tostes R C; Schiffrin E L; Touyz R M
Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(9):1960-7.
2007: Ebrahimian Talin; He Ying; Schiffrin Ernesto L; Touyz Rhian M
Differential regulation of thioredoxin and NAD(P)H oxidase by angiotensin II in male and female mice.
Journal of hypertension 2007;25(6):1263-71.
2007: Tobe Sheldon W; Touyz Rhian M; Campbell Norm R C;
The Canadian Hypertension Education Program - a unique Canadian knowledge translation program.
The Canadian journal of cardiology 2007;23(7):551-5.
2007: Padwal Raj S; Hemmelgarn Brenda R; McAlister Finlay A; McKay Donald W; Grover Steven; Wilson Thomas; Penner Brian; Burgess Ellen; Bolli Peter; Hill Michael; Mahon Jeff; Myers Martin G; Abbott Carl; Schiffrin Ernest L; Honos George; Mann Karen; Tremblay Guy; Milot Alain; Cloutier Lyne; Chockalingam Arun; Khan Nadia A; Rabkin Simon W; Dawes Martin; Touyz Rhian M; Tobe Sheldon W;
The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk.
The Canadian journal of cardiology 2007;23(7):529-38.
2007: Callera Glaucia; Tostes Rita; Savoia Carmine; Muscara M N; Touyz Rhian M
Vasoactive peptides in cardiovascular (patho)physiology.
Expert review of cardiovascular therapy 2007;5(3):531-52.
2007: De Ciuceis C; Amiri F; Iglarz M; Cohn J S; Touyz R M; Schiffrin E L
Synergistic vascular protective effects of combined low doses of PPARalpha and PPARgamma activators in angiotensin II-induced hypertension in rats.
British journal of pharmacology 2007;151(1):45-53.
2007: Ko Eun A; Amiri Farhad; Pandey Nihar R; Javeshghani Danesh; Leibovitz Eyal; Touyz Rhian M; Schiffrin Ernesto L
Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice.
American journal of physiology. Heart and circulatory physiology 2007;292(4):H1789-95.
2007: White Michel; Lepage Serge; Lavoie Joel; De Denus Simon; Leblanc Marie-Hélène; Gossard Denis; Whittom Lucette; Racine Normand; Ducharme Anique; Dabouz Farida; Rouleau Jean-Lucien; Touyz Rhian
Effects of combined candesartan and ACE inhibitors on BNP, markers of inflammation and oxidative stress, and glucose regulation in patients with symptomatic heart failure.
Journal of cardiac failure 2007;13(2):86-94.
2007: Callera Glaucia E; Montezano Augusto Ci; Yogi Alvaro; Tostes Rita Ca; Touyz Rhian M
Vascular signaling through cholesterol-rich domains: implications in hypertension.
Current opinion in nephrology and hypertension 2007;16(2):90-104.
2007: Touyz Rhian M
Regulation of endothelial nitric oxide synthase by thrombin.
Hypertension 2007;49(3):429-31.
2007: Savoia Carmine; Touyz Rhian M; Volpe Massimo; Schiffrin Ernesto L
Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients.
Hypertension 2007;49(2):341-6.
2007: Sontia Bruno; Touyz Rhian M
Role of magnesium in hypertension.
Archives of biochemistry and biophysics 2007;458(1):33-9.
2007: Vokurkova Martina; Xu Shaoping; Touyz Rhian M
Reactive oxygen species, cell growth, cell cycle progression and vascular remodeling in hypertension.
Future cardiology 2007;3(1):53-63.
2007: Sampaio Walkyria Oliveira; Souza dos Santos Robson Augusto; Faria-Silva Raphael; da Mata Machado Leonor Tapias; Schiffrin Ernesto L; Touyz Rhian M
Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways.
Hypertension 2007;49(1):185-92.
2006: Savoia Carmine; Ebrahimian Talin; He Ying; Gratton Jean-Philippe; Schiffrin Ernesto L; Touyz Rhian M
Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase.
Journal of hypertension 2006;24(12):2417-22.
2006: Xu Shaoping; Touyz Rhian M
Reactive oxygen species and vascular remodelling in hypertension: still alive.
The Canadian journal of cardiology 2006;22(11):947-51.
2006: Savoia Carmine; Touyz Rhian M; Endemann Dierk H; Pu Qian; Ko Eun A; De Ciuceis Carolina; Schiffrin Ernesto L
Angiotensin receptor blocker added to previous antihypertensive agents on arteries of diabetic hypertensive patients.
Hypertension 2006;48(2):271-7.
2006: Javeshghani Danesh; Sairam M Ram; Neves Mario Fritsch; Schiffrin Ernesto L; Touyz Rhian M
Angiotensin II induces vascular dysfunction without exacerbating blood pressure elevation in a mouse model of menopause-associated hypertension.
Journal of hypertension 2006;24(7):1365-73.
2006: Touyz Rhian M; Schiffrin Ernesto L
Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications.
Vascular pharmacology 2006;45(1):19-28.
2006: Paravicini Tamara M; Touyz Rhian M
Redox signaling in hypertension.
Cardiovascular research 2006;71(2):247-58.
2006: Hemmelgarn B R; McAlister Finlay A; Grover Steven; Myers Martin G; McKay Donald W; Bolli Peter; Abbott Carl; Schiffrin Ernesto L; Honos George; Burgess Ellen; Mann Karen; Wilson Thomas; Penner Brian; Tremblay Guy; Milot Alain; Chockalingam Arun; Touyz Rhian M; Tobe Sheldon W;
The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part I--Blood pressure measurement, diagnosis and assessment of risk.
The Canadian journal of cardiology 2006;22(7):573-81.
2006: Touyz R M;
Highlights and summary of the 2006 Canadian Hypertension Education Program recommendations.
The Canadian journal of cardiology 2006;22(7):565-71.
2006: Touyz Rhian M
Mitochondrial redox control of matrix metalloproteinase signaling in resistance arteries.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):685-8.
2006: White Michel; Ducharme Anique; Ibrahim Reda; Whittom Lucette; Lavoie Joel; Guertin Marie-Claude; Racine Normand; He Ying; Yao Guoying; Rouleau Jean L; Schiffrin Ernesto L; Touyz Rhian M
Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support.
Clinical science (London, England : 1979) 2006;110(4):483-9.
2006: Touyz Rhian M
Magnesium and hypertension.
Current opinion in nephrology and hypertension 2006;15(2):141-4.
2006: Callera Glaucia E; Tostes Rita C; Yogi Alvaro; Montezano Augusto C I; Touyz Rhian M
Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms.
Clinical science (London, England : 1979) 2006;110(2):243-53.
2006: Touyz Rhian M
Lipid rafts take center stage in endothelial cell redox signaling by death receptors.
Hypertension 2006;47(1):16-8.
2006: Touyz Rhian M; He Ying; Montezano Augusto C I; Yao Guoying; Chubanov Vladimir; Gudermann Thomas; Callera Glaucia E
Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(1):R73-8.
2005: Jamnik Veronica K; Gledhill Norman; Touyz Rhian M; Campbell Norman R C; Logan Alexander G; Padwal Raj; Petrella Rob
Lifestyle modifications to prevent and manage hypertension for exercise physiologists and fitness professionals.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquée 2005;30(6):754-61.
2005: Touyz Rhian M
Endothelial cell IL-8, a new target for adiponectin: implications in vascular protection.
Circulation research 2005;97(12):1216-9.
2005: Tabet Fatiha; Schiffrin Ernesto L; Touyz Rhian M
Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats.
Journal of hypertension 2005;23(11):2005-12.
2005: Callera Glaucia E; Montezano Augusto C I; Yogi Alvaro; Tostes Rita C; He Ying; Schiffrin Ernesto L; Touyz Rhian M
c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats.
Hypertension 2005;46(4):1032-8.
2005: De Ciuceis Carolina; Amiri Farhad; Brassard Pascal; Endemann Dierk H; Touyz Rhian M; Schiffrin Ernesto L
Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(10):2106-13.
2005: Padwal Rajdeep; Campbell Norman; Touyz Rhian M;
Applying the 2005 Canadian Hypertension Education Program recommendations: 3. Lifestyle modifications to prevent and treat hypertension.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2005;173(7):749-51.
2005: Touyz Rhian M
Reactive oxygen species as mediators of calcium signaling by angiotensin II: implications in vascular physiology and pathophysiology.
Antioxidants & redox signaling 2005;7(9-10):1302-14.
2005: Santos Robson A S; Ferreira Anderson J; Pinheiro Sérgio V B; Sampaio Walkyria O; Touyz Rhian; Campagnole-Santos Maria José
Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs.
Expert opinion on investigational drugs 2005;14(8):1019-31.
2005: Touyz Rhian M
Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin II.
Experimental physiology 2005;90(4):449-55.
2005: Savoia Carmine; Tabet Fatiha; Yao Guoying; Schiffrin Ernesto L; Touyz Rhian M
Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats.
Journal of hypertension 2005;23(5):1037-45.
2005: Touyz Rhian M; Mercure Chantel; He Ying; Javeshghani Danesh; Yao Guoying; Callera Glaucia E; Yogi Alvaro; Lochard Nadheige; Reudelhuber Timothy L
Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.
Hypertension 2005;45(4):530-7.
2005: Callera Glaucia E; Touyz Rhian M; Tostes Rita C; Yogi Alvaro; He Ying; Malkinson Sam; Schiffrin Ernesto L
Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src.
Hypertension 2005;45(4):773-9.
2005: Touyz Rhian M
Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II.
Current opinion in nephrology and hypertension 2005;14(2):125-31.
2005: Touyz R M; Yao G; Quinn M T; Pagano P J; Schiffrin E L
p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):512-8.
2005: Schiffrin Ernesto L; Touyz Rhian M
Calcium, magnesium, and oxidative stress in hyperaldosteronism.
Circulation 2005;111(7):830-1.
2005: Beaucage Pierre; Iglarz Marc; Servant Marc; Touyz Rhian M; Moreau Pierre
Position of Src tyrosine kinases in the interaction between angiotensin II and endothelin in in vivo vascular protein synthesis.
Journal of hypertension 2005;23(2):329-35.
2005: He Ying; Yao Guoying; Savoia Carmine; Touyz Rhian M
Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II.
Circulation research 2005;96(2):207-15.
2005: Touyz Rhian M; Yao Guoying; Schiffrin Ernesto L
Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells.
Canadian journal of physiology and pharmacology 2005;83(1):91-7.
2005: Cruzado Montserrat C; Risler Norma R; Miatello Roberto M; Yao Guoying; Schiffrin Ernesto L; Touyz Rhian M
Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation.
American journal of hypertension 2005;18(1):81-7.
2004: Amiri Farhad; Virdis Agostino; Neves Mario Fritsch; Iglarz Marc; Seidah Nabil G; Touyz Rhian M; Reudelhuber Timothy L; Schiffrin Ernesto L
Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction.
Circulation 2004;110(15):2233-40.
2004: Touyz R M; Schiffrin E L
Reactive oxygen species in vascular biology: implications in hypertension.
Histochemistry and cell biology 2004;122(4):339-52.
2004: Touyz Rhian M
Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?
Hypertension 2004;44(3):248-52.
2004: Schiffrin Ernesto L; Touyz Rhian M
From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension.
American journal of physiology. Heart and circulatory physiology 2004;287(2):H435-46.
2004: Touyz R M
Reactive oxygen species and angiotensin II signaling in vascular cells -- implications in cardiovascular disease.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2004;37(8):1263-73.
2004: Tabet Fatiha; Savoia Carmine; Schiffrin Ernesto L; Touyz Rhian M
Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2004;44(2):200-8.
2004: Iglarz Marc; Touyz Rhian M; Viel Emilie C; Amiri Farhad; Schiffrin Ernesto L
Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction wtih the renin-angiotension system.
American journal of hypertension 2004;17(7):597-603.
2004: Touyz Rhian M; Yao Guoying; Viel Emilie; Amiri Farhad; Schiffrin Ernesto L
Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells.
Journal of hypertension 2004;22(6):1141-9.
2004: Endemann Dierk H; Touyz Rhian M; Iglarz Marc; Savoia Carmine; Schiffrin Ernesto L
Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats.
Hypertension 2004;43(6):1252-7.
2004: Lochard Nadheige; Thibault Gaétan; Silversides David W; Touyz Rhian M; Reudelhuber Timothy L
Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist.
Circulation research 2004;94(11):1451-7.
2004: Daigle Christine; Martens Fabrice M A C; Girardot Daphné; Dao Huy Hao; Touyz Rhian M; Moreau Pierre
Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo.
BMC cardiovascular disorders 2004;4():6.
2004: Touyz Rhian M
Magnesium in clinical medicine.
Frontiers in bioscience : a journal and virtual library 2004;9():1278-93.
2004: El Mabrouk Mohammed; Diep Quy N; Benkirane Karim; Touyz Rhian M; Schiffrin Ernesto L
SAM68: a downstream target of angiotensin II signaling in vascular smooth muscle cells in genetic hypertension.
American journal of physiology. Heart and circulatory physiology 2004;286(5):H1954-62.
2004: Callera Glaucia E; Montezano Augusto C; Touyz Rhian M; Zorn Telma M T; Carvalho Maria Helena C; Fortes Zuleica B; Nigro Dorothy; Schiffrin Ernesto L; Tostes Rita C
ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats.
Hypertension 2004;43(4):872-9.
2004: Virdis Agostino; Neves Mario Fritsch; Amiri Farhad; Touyz Rhian M; Schiffrin Ernesto L
Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice.
Journal of hypertension 2004;22(3):535-42.
2004: Endemann Dierk H; Pu Qian; De Ciuceis Carolina; Savoia Carmine; Virdis Agostino; Neves Mario F; Touyz Rhian M; Schiffrin Ernesto L
Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment.
Hypertension 2004;43(2):399-404.
2004: Touyz R M; Campbell N; Logan A; Gledhill N; Petrella R; Padwal R;
The 2004 Canadian recommendations for the management of hypertension: Part III--Lifestyle modifications to prevent and control hypertension.
The Canadian journal of cardiology 2004;20(1):55-9.
2003: Touyz Rhian M
Activated oxygen metabolites: do they really play a role in angiotensin II-regulated vascular tone?
Journal of hypertension 2003;21(12):2235-8.
2003: Touyz Rhian M; Yao Guoying
Modulation of vascular smooth muscle cell growth by magnesium-role of mitogen-activated protein kinases.
Journal of cellular physiology 2003;197(3):326-35.
2003: Touyz Rhian M; Tabet Fatiha; Schiffrin Ernesto L
Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension.
Clinical and experimental pharmacology & physiology 2003;30(11):860-6.
2003: Callera Glaucia E; Touyz Rhian M; Teixeira Simone A; Muscara Marcelo N; Carvalho Maria Helena C; Fortes Zuleica B; Nigro Dorothy; Schiffrin Ernesto L; Tostes Rita C
ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension.
Hypertension 2003;42(4):811-7.
2003: Javeshghani Danesh; Touyz Rhian M; Sairam M Ram; Virdis Agostino; Neves Mario Fritsch; Schiffrin Ernesto L
Attenuated responses to angiotensin II in follitropin receptor knockout mice, a model of menopause-associated hypertension.
Hypertension 2003;42(4):761-7.
2003: Iglarz Marc; Touyz Rhian M; Viel Emilie C; Paradis Pierre; Amiri Farhad; Diep Quy N; Schiffrin Ernesto L
Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension.
Hypertension 2003;42(4):737-43.
2003: Schiffrin Ernesto L; Touyz Rhian M
Multiple actions of angiotensin II in hypertension: benefits of AT1 receptor blockade.
Journal of the American College of Cardiology 2003;42(5):911-3.
2003: Virdis Agostino; Iglarz Marc; Neves Mario Fritsch; Amiri Farhad; Touyz Rhian M; Rozen Rima; Schiffrin Ernesto L
Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):1352-7.
2003: Touyz Rhian M; Yao Guoying
Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger.
Clinical science (London, England : 1979) 2003;105(2):235-42.
2003: Pu Qian; Neves Mario Fritsch; Virdis Agostino; Touyz Rhian M; Schiffrin Ernesto L
Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling.
Hypertension 2003;42(1):49-55.
2003: Touyz Rhian M; Schiffrin Ernesto L
Role of endothelin in human hypertension.
Canadian journal of physiology and pharmacology 2003;81(6):533-41.
2003: Touyz R M; Yao G; Schiffrin E L
c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(6):981-7.
2003: Touyz Rhian M
Reactive oxygen species in vascular biology: role in arterial hypertension.
Expert review of cardiovascular therapy 2003;1(1):91-106.
2003: Schiffrin Ernesto L; Touyz Rhian M
Inflammation and vascular hypertrophy induced by angiotensin II: role of NADPH oxidase-derived reactive oxygen species independently of blood pressure elevation?
Arteriosclerosis, thrombosis, and vascular biology 2003;23(5):707-9.
2003: Touyz Rhian M
Pressure-induced expression of vascular neuronal nitric oxide synthase: adaptive or maladaptive response in arteries?
Journal of hypertension 2003;21(5):863-5.
2003: Touyz Rhian M
The role of angiotensin II in regulating vascular structural and functional changes in hypertension.
Current hypertension reports 2003;5(2):155-64.
2003: Touyz Rhian M
Recent advances in intracellular signalling in hypertension.
Current opinion in nephrology and hypertension 2003;12(2):165-74.
2003: Touyz Rhian M; Cruzado Montserrat; Tabet Fatiha; Yao Guoying; Salomon Steven; Schiffrin Ernesto L
Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation.
Canadian journal of physiology and pharmacology 2003;81(2):159-67.
2003: Touyz Rhian M; Yao Guoying
Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats.
Journal of hypertension 2003;21(2):337-44.
2003: Iglarz Marc; Touyz Rhian M; Amiri Farhad; Lavoie Marie-France; Diep Quy N; Schiffrin Ernesto L
Effect of peroxisome proliferator-activated receptor-alpha and -gamma activators on vascular remodeling in endothelin-dependent hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):45-51.
2002: Diep Quy N; Amiri Farhad; Touyz Rhian M; Cohn Jeffrey S; Endemann Dierk; Neves Mario Fritsch; Schiffrin Ernesto L
PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation.
Hypertension 2002;40(6):866-71.
2002: Touyz Rhian M; Pu Qian; He Gang; Chen Xin; Yao Guoying; Neves Mario Fritsch; Viel Emilie
Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats: role of reactive oxygen species.
Journal of hypertension 2002;20(11):2221-32.
2002: Virdis Agostino; Neves Mario Fritsch; Amiri Farhad; Viel Emilie; Touyz Rhian M; Schiffrin Ernesto L
Spironolactone improves angiotensin-induced vascular changes and oxidative stress.
Hypertension 2002;40(4):504-10.
2002: Touyz R M; Berry C
Recent advances in angiotensin II signaling.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2002;35(9):1001-15.
2002: Tostes Rita C A; Touyz Rhian M; He Gang; Chen Xin; Schiffrin Ernesto L
Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension.
Clinical science (London, England : 1979) 2002;103 Suppl 48():25S-30S.
2002: Endemann Dierk; Touyz Rhian M; Yao Guoying; Schiffrin Ernesto L
Tyrosine kinase inhibition attenuates vasopressin-induced contraction of mesenteric resistance arteries: alterations in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2002;40(1):123-32.
2002: Zarnke Kelly B; McAlister Finlay A; Campbell Norman R C; Levine Mitchell; Schiffrin Ernesto L; Grover Steven; McKay Donald W; Myers Martin G; Wilson Thomas W; Rabkin Simon W; Feldman Ross D; Burgess Ellen; Bolli Peter; Honos George; Lebel Marcel; Mann Karen; Abbott Carl; Tobe Sheldon; Petrella Robert; Touyz Rhian M;
The 2001 Canadian recommendations for the management of hypertension: Part one--Assessment for diagnosis, cardiovascular risk, causes and lifestyle modification.
The Canadian journal of cardiology 2002;18(6):604-24.
2002: Touyz Rhian M; Chen Xin; Tabet Fatiha; Yao Guoying; He Gang; Quinn Mark T; Pagano Patrick J; Schiffrin Ernesto L
Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II.
Circulation research 2002;90(11):1205-13.
2002: Touyz Rhian M; Deschepper Christian; Park Jeong Bae; He Gang; Chen Xin; Neves Mario Fritsch T; Virdis Agostino; Schiffrin Ernesto L
Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats.
Journal of hypertension 2002;20(6):1127-34.
2002: Tostes Rita C A; Touyz Rhian M; He Gang; Ammarguellat Fatima; Schiffrin Ernesto L
Endothelin A receptor blockade decreases expression of growth factors and collagen and improves matrix metalloproteinase-2 activity in kidneys from stroke-prone spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2002;39(6):892-900.
2002: Pu Qian; Touyz Rhian M; Schiffrin Ernesto L
Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats.
Journal of hypertension 2002;20(5):899-907.
2002: Touyz Rhian M
Impaired vasorelaxation in hypertension: beyond the endothelium.
Journal of hypertension 2002;20(3):371-3.
2002: Touyz Rhian M; Wu Xiao-Hua; He Gang; Salomon Steven; Schiffrin Ernesto L
Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased C-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats.
Hypertension 2002;39(2 Pt 2):479-85.
2002: Park Jeong Bae; Touyz Rhian M; Chen Xin; Schiffrin Ernesto L
Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats.
American journal of hypertension 2002;15(1 Pt 1):78-84.
2002: Deschepper Christian F; Picard Sylvie; Thibault Gaétan; Touyz Rhian; Rouleau Jean-Lucien
Characterization of myocardium, isolated cardiomyocytes, and blood pressure in WKHA and WKY rats.
American journal of physiology. Heart and circulatory physiology 2002;282(1):H149-55.
2001: Chen X; Touyz R M; Park J B; Schiffrin E L
Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR.
Hypertension 2001;38(3 Pt 2):606-11.
2001: Touyz R M; He G; Wu X H; Park J B; Mabrouk M E; Schiffrin E L
Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients.
Hypertension 2001;38(1):56-64.
2001: Touyz R M; Schiffrin E L
Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways.
Journal of hypertension 2001;19(7):1245-54.
2001: El Mabrouk M; Touyz R M; Schiffrin E L
Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR.
American journal of physiology. Heart and circulatory physiology 2001;281(1):H30-9.
2001: McAlister F A; Levine M; Zarnke K B; Campbell N; Lewanczuk R; Leenen F; Rabkin S; Wright J M; Stone J; Feldman R D; Lebel M; Honos G; Fodor G; Burgess E; Tobe S; Hamet P; Herman R; Irvine J; Culleton B; Petrella R; Touyz R;
The 2000 Canadian recommendations for the management of hypertension: Part one--therapy.
The Canadian journal of cardiology 2001;17(5):543-59.
2001: Touyz R M; Mercure C; Reudelhuber T L
Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms.
The Journal of biological chemistry 2001;276(17):13657-63.
2001: Touyz R M; He G; El Mabrouk M; Diep Q; Mardigyan V; Schiffrin E L
Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats.
Journal of hypertension 2001;19(3 Pt 2):553-9.
2001: Touyz R M; Wu X H; He G; Park J B; Chen X; Vacher J; Rajapurohitam V; Schiffrin E L
Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells.
Journal of hypertension 2001;19(3):441-9.
2001: Diep Q N; El Mabrouk M; Touyz R M; Schiffrin E L
Expression of cell cycle proteins in blood vessels of angiotensin II-infused rats: role of AT(1) receptors.
Hypertension 2001;37(2 Part 2):604-8.
2001: Touyz R M; He G; El Mabrouk M; Schiffrin E L
p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY.
Hypertension 2001;37(2 Part 2):574-80.
2000: Diep Q N; Touyz R M; Schiffrin E L
Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase.
Hypertension 2000;36(5):851-5.
2000: Touyz R M; Turgeon A; Schiffrin E L
Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S300-4.
2000: Touyz R M
Molecular and cellular mechanisms regulating vascular function and structure--implications in the pathogenesis of hypertension.
The Canadian journal of cardiology 2000;16(9):1137-46.
2000: Schiffrin E L; Park J B; Intengan H D; Touyz R M
Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan.
Circulation 2000;101(14):1653-9.
2000: Fareh J; Touyz R M; Schiffrin E L; Thibault G
Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats.
Journal of molecular and cellular cardiology 2000;32(4):665-76.
2000: Touyz R M
Oxidative stress and vascular damage in hypertension.
Current hypertension reports 2000;2(1):98-105.
1999: Touyz R M; Schiffrin E L
Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells.
Hypertension 1999;34(4 Pt 2):976-82.
1999: Touyz R M; Schiffrin E L
Activation of the Na(+)-H+ exchanger modulates angiotensin II-stimulated Na(+)-dependent Mg2+ transport in vascular smooth muscle cells in genetic hypertension.
Hypertension 1999;34(3):442-9.
1999: Touyz R M; Deng L Y; He G; Wu X H; Schiffrin E L
Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases.
Journal of hypertension 1999;17(7):907-16.
1999: Endemann D; Touyz R M; Li J S; Deng L Y; Schiffrin E L
Altered angiotensin II-induced small artery contraction during the development of hypertension in spontaneously hypertensive rats.
American journal of hypertension 1999;12(7):716-23.
1999: Touyz R M; El Mabrouk M; He G; Wu X H; Schiffrin E L
Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells.
Circulation research 1999;84(5):505-15.
1999: Touyz R M; Endemann D; He G; Li J S; Schiffrin E L
Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR.
Hypertension 1999;33(1 Pt 2):366-72.
1999: Touyz R M; He G; Deng L Y; Schiffrin E L
Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human resistance arteries.
Circulation 1999;99(3):392-9.
1998: Touyz R M; Laurant P; Schiffrin E L
Effect of magnesium on calcium responses to vasopressin in vascular smooth muscle cells of spontaneously hypertensive rats.
The Journal of pharmacology and experimental therapeutics 1998;284(3):998-1005.
1998: Li J S; Touyz R M; Schiffrin E L
Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats.
Hypertension 1998;31(1 Pt 2):487-92.
1998: Schiffrin E L; Touyz R M
Vascular biology of endothelin.
Journal of cardiovascular pharmacology 1998;32 Suppl 3():S2-13.
1998: Sharifi A M; He G; Touyz R M; Schiffrin E L
Vascular endothelin-1 expression and effect of an endothelin ETA antagonist on structure and function of small arteries from stroke-prone spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S309-12.
1998: Touyz R M; Fareh J; Thibault G; Schiffrin E L
Endothelin-1 signaling is altered in cardiac cells from deoxycorticosterone acetate-salt hypertensive rats.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S179-81.
1997: Touyz R M; Schiffrin E L
Role of calcium influx and intracellular calcium stores in angiotensin II-mediated calcium hyper-responsiveness in smooth muscle from spontaneously hypertensive rats.
Journal of hypertension 1997;15(12 Pt 1):1431-9.
1997: Touyz R M; Schiffrin E L
Growth factors mediate intracellular signaling in vascular smooth muscle cells through protein kinase C-linked pathways.
Hypertension 1997;30(6):1440-7.
1997: Fareh J; Touyz R M; Schiffrin E L; Thibault G
Cardiac type-1 angiotensin II receptor status in deoxycorticosterone acetate-salt hypertension in rats.
Hypertension 1997;30(5):1253-9.
1997: Touyz R M; Schiffrin E L
Angiotensin II regulates vascular smooth muscle cell pH, contraction, and growth via tyrosine kinase-dependent signaling pathways.
Hypertension 1997;30(2 Pt 1):222-9.
1997: Lacroix A; Tremblay J; Touyz R M; Deng L Y; Lariviere R; Cusson J R; Schiffrin E L; Hamet P
Abnormal adrenal and vascular responses to vasopressin mediated by a V1-vasopressin receptor in a patient with adrenocorticotropin-independent macronodular adrenal hyperplasia, Cushing's syndrome, and orthostatic hypotension.
The Journal of clinical endocrinology and metabolism 1997;82(8):2414-22.
1997: Schiffrin E L; Intengan H D; Thibault G; Touyz R M
Clinical significance of endothelin in cardiovascular disease.
Current opinion in cardiology 1997;12(4):354-67.
1997: Methot D; LaPointe M C; Touyz R M; Yang X P; Carretero O A; Deschepper C F; Schiffrin E L; Thibault G; Reudelhuber T L
Tissue targeting of angiotensin peptides.
The Journal of biological chemistry 1997;272(20):12994-9.
1997: Touyz R M; Picard S; Schiffrin E L; Deschepper C F
Cyclic GMP inhibits a pharmacologically distinct Na+/H+ exchanger variant in cultured rat astrocytes via an extracellular site of action.
Journal of neurochemistry 1997;68(4):1451-61.
1996: Touyz R M; Fareh J; Thibault G; Schiffrin E L
Intracellular Ca2+ modulation by angiotensin II and endothelin-1 in cardiomyocytes and fibroblasts from hypertrophied hearts of spontaneously hypertensive rats.
Hypertension 1996;28(5):797-805.
1996: Touyz R M; Schiffrin E L
Angiotensin II and vasopressin modulate intracellular free magnesium in vascular smooth muscle cells through Na+-dependent protein kinase C pathways.
The Journal of biological chemistry 1996;271(40):24353-8.
1996: Touyz R M; Deng L Y; Li J S; Schiffrin E L
Differential effects of vasopressin and endothelin-1 on vascular contractile and calcium responses in pressurized small arteries from spontaneously hypertensive rats.
Journal of hypertension 1996;14(8):983-91.
1996: Yang X P; Touyz R M; Nguyen P V; Deng L Y; Li J S; Schiffrin E L
Endothelin-1 and vasopressin signalling in blood vessels of young SHR in comparison to adult SHR.
Hypertension research : official journal of the Japanese Society of Hypertension 1996;19(2):121-32.
1996: Touyz R M; Schiffrin E L
Tyrosine kinase signaling pathways modulate angiotensin II-induced calcium ([Ca2+]i) transients in vascular smooth muscle cells.
Hypertension 1996;27(5):1097-103.
1996: Touyz R M; Sventek P; Larivière R; Thibault G; Fareh J; Reudelhuber T; Schiffrin E L
Cytosolic calcium changes induced by angiotensin II in neonatal rat atrial and ventricular cardiomyocytes are mediated via angiotensin II subtype 1 receptors.
Hypertension 1996;27(5):1090-6.
1996: Touyz R M; Fareh J; Thibault G; Tolloczko B; Larivière R; Schiffrin E L
Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by angiotensin II and endothelin-1.
The American journal of physiology 1996;270(3 Pt 2):H857-68.
1996: Fareh J; Touyz R M; Schiffrin E L; Thibault G
Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart. Receptor regulation and intracellular Ca2+ modulation.
Circulation research 1996;78(2):302-11.
1995: Schiffrin E L; Lariviere R; Touyz R M
ETA and ETB receptors on vascular smooth muscle cells from mesenteric vessels of spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology. Supplement 1995;22(1):S193-4.
1995: Schiffrin E L; Lariviere R; Li J S; Sventek P; Touyz R M
Endothelin-1 gene expression and vascular hypertrophy in DOCA-salt hypertension compared to spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology. Supplement 1995;22(1):S188-90.
1995: Touyz R M; Schiffrin E L
Treatment of non-insulin-dependent diabetic hypertensive patients with Ca2+ channel blockers is associated with increased platelet sensitivity to insulin.
American journal of hypertension 1995;8(12 Pt 1):1214-21.
1995: Fareh J; Touyz R M; Thibault G; Schiffrin E L
Basal and angiotensin II-induced cytosolic free calcium in adult rat cardiomyocytes and fibroblasts after volume overload.
Hypertension 1995;26(6 Pt 2):1149-53.
1995: Touyz R M; Deng L Y; Schiffrin E L
Endothelin subtype B receptor-mediated calcium and contractile responses in small arteries of hypertensive rats.
Hypertension 1995;26(6 Pt 2):1041-5.
1995: Touyz R M; Larivière R; Schiffrin E L
Endothelin receptor subtypes in mesenteric vascular smooth muscle cells of spontaneously hypertensive rats.
Canadian journal of physiology and pharmacology 1995;73(9):1262-73.
1995: Touyz R M; Larivière R; Schiffrin E L
Endothelin influences pHi of human platelets through protein kinase C mediated pathways.
Thrombosis research 1995;78(1):55-65.
1995: Schiffrin E L; Larivière R; Li J S; Sventek P; Touyz R M
Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats.
Hypertension 1995;25(4 Pt 2):769-73.
1995: Touyz R M; Schiffrin E L
Role of protein kinase C in the anti-aggregatory effects of endothelin-1 on human platelets.
Clinical science (London, England : 1979) 1995;88(3):277-83.
1995: Touyz R M; Tolloczko B; Schiffrin E L
Blunted attenuation of angiotensin II-mediated Ca2+ transients by insulin in cultured unpassaged vascular smooth muscle cells from spontaneously hypertensive rats.
American journal of hypertension 1995;8(2):104-12.
1995: Schiffrin E L; Larivière R; Li J S; Sventek P; Touyz R M
Enhanced expression of endothelin-1 gene may cause blood pressure-independent vascular hypertrophy.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S5-8.
1995: Touyz R M; Fareh J; Thibault G; Larivière R; Schiffrin E L
Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by endothelin-1.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S297-9.
1995: Touyz R M; Deng L Y; Schiffrin E L
Ca2+ and contractile responses of resistance vessels of WKY rats and SHR to endothelin-1.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S193-6.
1994: Touyz R M; Schiffrin E L
Blunted inhibition by insulin of agonist-stimulated calcium, pH and aggregatory responses in platelets from hypertensive patients.
Journal of hypertension 1994;12(11):1255-63.
1994: Touyz R M; Schiffrin E L
Insulin-induced Ca2+ transport is altered in vascular smooth muscle cells of spontaneously hypertensive rats.
Hypertension 1994;23(6 Pt 2):931-5.
1994: Touyz R M; Tolloczko B; Schiffrin E L
Mesenteric vascular smooth muscle cells from spontaneously hypertensive rats display increased calcium responses to angiotensin II but not to endothelin-1.
Journal of hypertension 1994;12(6):663-73.
1994: Touyz R M; Tolloczko B; Schiffrin E L
Insulin attenuates agonist-evoked calcium transients in vascular smooth muscle cells.
Hypertension 1994;23(1 Suppl):I25-8.
1993: Touyz R M; Schiffrin E L
Effects of angiotensin II and endothelin-1 on platelet aggregation and cytosolic pH and free Ca2+ concentrations in essential hypertension.
Hypertension 1993;22(6):853-62.
1993: Touyz R M; Schiffrin E L
The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension.
Journal of hypertension 1993;11(5):551-8.

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