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William Bosron

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Anatomy

Liver

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Phenomena

Oxidation-Reduction

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Co-Publications
Name
27
Hurley, Thomas
26
Li, Ting-Kai
15
Stone, CL
10
Dean, RA
10
Edenberg, Howard
9
Sanghani, Sonal
8
Brzezinski, MR
7
Kedishvili, Natalia
7
Davis, Wilhelmina
7
Sanghani, Paresh
5
Carr, Lucinda
4
Murry, Daryl
3
Pindel, EV
3
Popov, Kirill
3
Quinney, Sara

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Publications

TOP 3
Sanghani Sonal P; Sanghani Paresh C; Schiel Marissa A; Bosron William F
Human carboxylesterases: an update on CES1, CES2 and CES3.
Mello Tommaso; Nakatsuka Alice; Fears Sharry; Davis Wilhelmina; Tsukamoto Hidekazu; Bosron William F; Sanghani Sonal P
Expression of carboxylesterase and lipase genes in rat liver cell-types.
Janecki Dariusz J; Bemis Kerry G; Tegeler Tony J; Sanghani Paresh C; Zhai Lanmin; Hurley Thomas D; Bosron William F; Wang Mu
A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme.

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All Publications

2009: Sanghani Sonal P; Sanghani Paresh C; Schiel Marissa A; Bosron William F
Human carboxylesterases: an update on CES1, CES2 and CES3.
Protein and peptide letters 2009;16(10):1207-14.
2008: Mello Tommaso; Nakatsuka Alice; Fears Sharry; Davis Wilhelmina; Tsukamoto Hidekazu; Bosron William F; Sanghani Sonal P
Expression of carboxylesterase and lipase genes in rat liver cell-types.
Biochemical and biophysical research communications 2008;374(3):460-4.
2007: Janecki Dariusz J; Bemis Kerry G; Tegeler Tony J; Sanghani Paresh C; Zhai Lanmin; Hurley Thomas D; Bosron William F; Wang Mu
A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme.
Analytical biochemistry 2007;369(1):18-26.
2007: Schiel Marissa A; Green Scheri-lyn; Davis Wilhelmina I; Sanghani Paresh C; Bosron William F; Sanghani Sonal P
Expression and characterization of a human carboxylesterase 2 splice variant.
The Journal of pharmacology and experimental therapeutics 2007;323(1):94-101.
2005: Quinney S K; Sanghani S P; Davis W I; Hurley T D; Sun Z; Murry D J; Bosron W F
Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1011-6.
2004: Sun Zejin; Murry Daryl J; Sanghani Sonal P; Davis Wilhelmina I; Kedishvili Natalia Y; Zou Qin; Hurley Thomas D; Bosron William F
Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1.
The Journal of pharmacology and experimental therapeutics 2004;310(2):469-76.
2004: Sanghani Sonal P; Quinney Sara K; Fredenburg Tyler B; Davis Wilhelmina I; Murry Daryl J; Bosron William F
Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(5):505-11.
2003: Sanghani Sonal P; Quinney Sara K; Fredenburg Tyler B; Sun Zejin; Davis Wilhelmina I; Murry Daryl J; Cummings Oscar W; Seitz David E; Bosron William F
Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4983-91.
2003: Sanghani Paresh C; Robinson Howard; Bennett-Lovsey Riccardo; Hurley Thomas D; Bosron W F
Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase).
Chemico-biological interactions 2003;143-144():195-200.
2002: Sanghani Paresh C; Bosron William F; Hurley Thomas D
Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation.
Biochemistry 2002;41(51):15189-94.
2002: Sanghani Sonal P; Davis Wilhelmina I; Dumaual Natividad G; Mahrenholz Alan; Bosron William F
Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate.
European journal of biochemistry / FEBS 2002;269(18):4387-98.
2002: Sanghani Paresh C; Robinson Howard; Bosron William F; Hurley Thomas D
Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes.
Biochemistry 2002;41(35):10778-86.
2002: Satoh Tetsuo; Taylor Palmer; Bosron William F; Sanghani Sonal P; Hosokawa Masakiyo; La Du Bert N
Current progress on esterases: from molecular structure to function.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(5):488-93.
2002: Bosron William F; Hurley Thomas D
Lessons from a bacterial cocaine esterase.
Nature structural biology 2002;9(1):4-5.
2001: Ramchandani V A; Bosron W F; Li T K
Research advances in ethanol metabolism.
Pathologie-biologie 2001;49(9):676-82.
2001: Crabb D W; Pinairs J; Hasanadka R; Fang M; Leo M A; Lieber C S; Tsukamoto H; Motomura K; Miyahara T; Ohata M; Bosron W; Sanghani S; Kedishvili N; Shiraishi H; Yokoyama H; Miyagi M; Ishii H; Bergheim I; Menzl I; Parlesak A; Bode C
Alcohol and retinoids.
Alcoholism, clinical and experimental research 2001;25(5 Suppl ISBRA):207S-217S.
2000: Sanghani P C; Stone C L; Ray B D; Pindel E V; Hurley T D; Bosron W F
Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase.
Biochemistry 2000;39(35):10720-9.
1999: Zhang J; Burnell J C; Dumaual N; Bosron W F
Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1.
The Journal of pharmacology and experimental therapeutics 1999;290(1):314-8.
1999: Stone C L; Jipping M B; Owusu-Dekyi K; Hurley T D; Li T K; Bosron W F
The pH-dependent binding of NADH and subsequent enzyme isomerization of human liver beta 3 beta 3 alcohol dehydrogenase.
Biochemistry 1999;38(18):5829-35.
1998: Kedishvili N Y; Gough W H; Davis W I; Parsons S; Li T K; Bosron W F
Effect of cellular retinol-binding protein on retinol oxidation by human class IV retinol/alcohol dehydrogenase and inhibition by ethanol.
Biochemical and biophysical research communications 1998;249(1):191-6.
1997: Brzezinski M R; Spink B J; Dean R A; Berkman C E; Cashman J R; Bosron W F
Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(9):1089-96.
1997: Xie P; Parsons S H; Speckhard D C; Bosron W F; Hurley T D
X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.
The Journal of biological chemistry 1997;272(30):18558-63.
1997: Pindel E V; Kedishvili N Y; Abraham T L; Brzezinski M R; Zhang J; Dean R A; Bosron W F
Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.
The Journal of biological chemistry 1997;272(23):14769-75.
1997: Kedishvili N Y; Gough W H; Chernoff E A; Hurley T D; Stone C L; Bowman K D; Popov K M; Bosron W F; Li T K
cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3beta,5alpha-hydroxysteroids.
The Journal of biological chemistry 1997;272(11):7494-500.
1997: Yang Z N; Bosron W F; Hurley T D
Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase.
Journal of molecular biology 1997;265(3):330-43.
1997: Dean R A; Bosron W F; Zachman F M; Zhang J; Brzezinski M R
Effects of ethanol on cocaine metabolism and disposition in the rat.
NIDA research monograph 1997;173():35-47.
1997: Bosron W F; Dean R A; Brzezinski M R; Pindel E V
Human liver cocaine carboxylesterases.
NIDA research monograph 1997;173():27-34.
1996: Kamendulis L M; Brzezinski M R; Pindel E V; Bosron W F; Dean R A
Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases.
The Journal of pharmacology and experimental therapeutics 1996;279(2):713-7.
1996: Davis G J; Bosron W F; Stone C L; Owusu-Dekyi K; Hurley T D
X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding.
The Journal of biological chemistry 1996;271(29):17057-61.
1996: Zhang J; Dean R A; Brzezinski M R; Bosron W F
Gender-specific differences in activity and protein levels of cocaine carboxylesterase in rat tissues.
Life sciences 1996;59(14):1175-84.
1995: Dean R A; Zhang J; Brzezinski M R; Bosron W F
Tissue distribution of cocaine methyl esterase and ethyl transferase activities: correlation with carboxylesterase protein.
The Journal of pharmacology and experimental therapeutics 1995;275(2):965-71.
1995: Stone C L; Hurley T D; Peggs C F; Kedishvili N Y; Davis G J; Thomasson H R; Li T K; Bosron W F
Cimetidine inhibition of human gastric and liver alcohol dehydrogenase isoenzymes: identification of inhibitor complexes by kinetics and molecular modeling.
Biochemistry 1995;34(12):4008-14.
1995: Kedishvili N Y; Bosron W F; Stone C L; Hurley T D; Peggs C F; Thomasson H R; Popov K M; Carr L G; Edenberg H J; Li T K
Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes.
The Journal of biological chemistry 1995;270(8):3625-30.
1995: Kedishvili N Y; Bosron W F; Stone C L; Peggs C F; Thomasson H R; Popov K M; Carr L G; Hurley T D; Edenberg H J; Li T K
Cloning and expression of a human stomach alcohol dehydrogenase isozyme.
Advances in experimental medicine and biology 1995;372():341-7.
1994: Brzezinski M R; Abraham T L; Stone C L; Dean R A; Bosron W F
Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine.
Biochemical pharmacology 1994;48(9):1747-55.
1994: Davis G J; Carr L G; Hurley T D; Li T K; Bosron W F
Comparative roles of histidine 51 in human beta 1 beta 1 and threonine 51 in pi pi alcohol dehydrogenases.
Archives of biochemistry and biophysics 1994;311(2):307-12.
1994: Hurley T D; Bosron W F; Stone C L; Amzel L M
Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.
Journal of molecular biology 1994;239(3):415-29.
1994: Yang Z N; Davis G J; Hurley T D; Stone C L; Li T K; Bosron W F
Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction.
Alcoholism, clinical and experimental research 1994;18(3):587-91.
1993: Stone C L; Thomasson H R; Bosron W F; Li T K
Purification and partial amino acid sequence of a high-activity human stomach alcohol dehydrogenase.
Alcoholism, clinical and experimental research 1993;17(4):911-8.
1993: Ehrig T; Muhoberac B B; Brems D; Bosron W F
Monomers of human beta 1 beta 1 alcohol dehydrogenase exhibit activity that differs from the dimer.
The Journal of biological chemistry 1993;268(16):11721-6.
1993: Bosron W F; Ehrig T; Li T K
Genetic factors in alcohol metabolism and alcoholism.
Seminars in liver disease 1993;13(2):126-35.
1993: Stone C L; Bosron W F; Dunn M F
Amino acid substitutions at position 47 of human beta 1 beta 1 and beta 2 beta 2 alcohol dehydrogenases affect hydride transfer and coenzyme dissociation rate constants.
The Journal of biological chemistry 1993;268(2):892-9.
1993: Hurley T D; Yang Z; Bosron W F; Weiner H
Crystallization and preliminary X-ray analysis of bovine mitochondrial aldehyde dehydrogenase and human glutathione-dependent formaldehyde dehydrogenase.
Advances in experimental medicine and biology 1993;328():245-50.
1993: Stone C L; Hurley T D; Amzel L M; Dunn M F; Bosron W F
Kinetics of a glycine for Arg-47 human alcohol dehydrogenase mutant can be explained by Lys-228 recruitment into the pyrophosphate binding site.
Advances in experimental medicine and biology 1993;328():429-37.
1992: Dean R A; Harper E T; Dumaual N; Stoeckel D A; Bosron W F
Effects of ethanol on cocaine metabolism: formation of cocaethylene and norcocaethylene.
Toxicology and applied pharmacology 1992;117(1):1-8.
1992: Ehrig T; Muhoberac B B; Hurley T D; Bosron W F
Tryptophan fluorescence quenching by alkaline pH and ternary complex formation in human beta 1 beta 1 and horse EE alcohol dehydrogenases.
FEBS letters 1992;300(3):283-5.
1992: Hurley T D; Bosron W F
Human alcohol dehydrogenase: dependence of secondary alcohol oxidation on the amino acids at positions 93 and 94.
Biochemical and biophysical research communications 1992;183(1):93-9.
1991: Dean R A; Christian C D; Sample R H; Bosron W F
Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(12):2735-9.
1991: Hurley T D; Bosron W F; Hamilton J A; Amzel L M
Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8149-53.
1991: Ehrig T; Hurley T D; Edenberg H J; Bosron W F
General base catalysis in a glutamine for histidine mutant at position 51 of human liver alcohol dehydrogenase.
Biochemistry 1991;30(4):1062-8.
1991: Hurley T D; Ehrig T; Edenberg H J; Bosron W F
Characterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51.
Advances in experimental medicine and biology 1991;284():271-5.
1990: Hurley T D; Edenberg H J; Bosron W F
Expression and kinetic characterization of variants of human beta 1 beta 1 alcohol dehydrogenase containing substitutions at amino acid 47.
The Journal of biological chemistry 1990;265(27):16366-72.
1990: Ehrig T; Bosron W F; Li T K
Alcohol and aldehyde dehydrogenase.
Alcohol and alcoholism (Oxford, Oxfordshire) 1990;25(2-3):105-16.
1989: Burnell J C; Li T K; Bosron W F
Purification and steady-state kinetic characterization of human liver beta 3 beta 3 alcohol dehydrogenase.
Biochemistry 1989;28(17):6810-5.
1989: Stone C L; Li T K; Bosron W F
Stereospecific oxidation of secondary alcohols by human alcohol dehydrogenases.
The Journal of biological chemistry 1989;264(19):11112-6.
1989: Crabb D W; Edenberg H J; Bosron W F; Li T K
Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.
The Journal of clinical investigation 1989;83(1):314-6.
1989: Stone C L; Burnell J C; Li T K; Bosron W F
Relationships between the kinetics of alcohol or coenzyme oxidoreduction and amino acid sequence of human liver alcohol dehydrogenase isoenzymes.
Progress in clinical and biological research 1989;290():155-65.
1988: Xu Y L; Carr L G; Bosron W F; Li T K; Edenberg H J
Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification.
Genomics 1988;2(3):209-14.
1988: Bosron W F; Lumeng L; Li T K
Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease.
Molecular aspects of medicine 1988;10(2):147-58.
1987: Burnell J C; Carr L G; Dwulet F E; Edenberg H J; Li T K; Bosron W F
The human beta 3 alcohol dehydrogenase subunit differs from beta 1 by a Cys for Arg-369 substitution which decreases NAD(H) binding.
Biochemical and biophysical research communications 1987;146(3):1127-33.
1987: Rex D K; Patterson L S; Edenberg H J; Bosron W F
Structure and expression of mouse liver alcohol dehydrogenase isoenzymes.
Progress in clinical and biological research 1987;232():237-43.
1987: Zhang K; Bosron W F; Edenberg H J
Structure of the mouse Adh-1 gene and identification of a deletion in a long alternating purine-pyrimidine sequence in the first intron of strains expressing low alcohol dehydrogenase activity.
Gene 1987;57(1):27-36.
1987: Patterson L S; Zhang K; Edenberg H J; Bosron W F
Genetic control of liver alcohol dehydrogenase expression in inbred mice.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1987;1():157-9.
1987: Crabb D W; Bosron W F; Li T K
Ethanol metabolism.
Pharmacology & therapeutics 1987;34(1):59-73.
1986: Bosron W F; Yin S J; Dwulet F E; Li T K
Selective carboxymethylation of cysteine-174 of the beta 2 beta 2 and beta 1 beta 1 human liver alcohol dehydrogenase isoenzymes by iodoacetate.
Biochemistry 1986;25(8):1876-81.
1985: Bosron W F; Gaither J W; Magnes L J
Kinetic characterization of two classes of dog liver alcohol dehydrogenase isoenzymes.
Alcoholism, clinical and experimental research 1985;9(3):228-34.
1985: Bosron W F; Yin S J; Li T K
Purification and characterization of human liver beta 1 beta 1, beta 2 beta 2 and beta Ind beta Ind alcohol dehydrogenase isoenzymes.
Progress in clinical and biological research 1985;174():193-206.
1984: Yin S J; Bosron W F; Magnes L J; Li T K
Human liver alcohol dehydrogenase: purification and kinetic characterization of the beta 2 beta 2, beta 2 beta 1, alpha beta 2, and beta 2 gamma 1 "Oriental" isoenzymes.
Biochemistry 1984;23(24):5847-53.
1984: Yin S J; Bosron W F; Li T K; Ohnishi K; Okuda K; Ishii H; Tsuchiya M
Polymorphism of human liver alcohol dehydrogenase: identification of ADH2 2-1 and ADH2 2-2 phenotypes in the Japanese by isoelectric focusing.
Biochemical genetics 1984;22(1-2):169-80.
1983: Bosron W F; Magnes L J; Li T K
Human liver alcohol dehydrogenase: ADH Indianapolis results from genetic polymorphism at the ADH2 gene locus.
Biochemical genetics 1983;21(7-8):735-44.
1983: Bosron W F; Magnes L J; Li T K
Kinetic and electrophoretic properties of native and recombined isoenzymes of human liver alcohol dehydrogenase.
Biochemistry 1983;22(8):1852-7.

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