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Minoru Toyota

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Physiology

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Genes, Tumor Suppressor

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Takashi Shimizu; Hiromu Suzuki; Takashi Tokino; Taiji Tsukamoto; Eiichiro Yamamoto; Masami Ashida; Tomo Hatahira; Kohzoh Imai; Masahiro Kai; Hiroshi Kitamura; Reo Maruyama; Naoya Masumori; Masanori Nojima; Minoru Toyota
Methylation of a Panel of MicroRNA Genes Is a Novel Biomarker for Detection of Bladder Cancer.
Rena Morita; Hiromu Suzuki; Akari Takahashi; Yasuaki Tamura; Takashi Tokino; Toshihiko Torigoe; Minoru Toyota; Masahiro Asaka; Hiroko Asanuma; Tadashi Hasegawa; Satoshi Hashino; Yoshihiko Hirohashi; Satoko Inoda; Takayuki Kanaseki; Toru Kondo; Noriyuki Sato
DNA methyltransferase 1 is essential for initiation of the colon cancers.
Takeshi Sawada; Yoshihiro Shioi; Hiromu Suzuki; Minoru Toyota; Eiichiro Yamamoto; Hiroyuki Yamamoto; Yasushi Adachi; Risaburo Akasaka; Masami Ashida; Taku Harada; Kohzoh Imai; Fumio Itoh; Masahiro Kai; Seiko Kamimae; Reo Maruyama; Masanori Nojima; Tamotsu Sugai
Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization.

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All Publications

2013: Takashi Shimizu; Hiromu Suzuki; Takashi Tokino; Taiji Tsukamoto; Eiichiro Yamamoto; Masami Ashida; Tomo Hatahira; Kohzoh Imai; Masahiro Kai; Hiroshi Kitamura; Reo Maruyama; Naoya Masumori; Masanori Nojima; Minoru Toyota
Methylation of a Panel of MicroRNA Genes Is a Novel Biomarker for Detection of Bladder Cancer.
European urology 2013;63(6):1091-100.
2013: Rena Morita; Hiromu Suzuki; Akari Takahashi; Yasuaki Tamura; Takashi Tokino; Toshihiko Torigoe; Minoru Toyota; Masahiro Asaka; Hiroko Asanuma; Tadashi Hasegawa; Satoshi Hashino; Yoshihiko Hirohashi; Satoko Inoda; Takayuki Kanaseki; Toru Kondo; Noriyuki Sato
DNA methyltransferase 1 is essential for initiation of the colon cancers.
Experimental and molecular pathology 2013;94(2):322-9.
2013: Takeshi Sawada; Yoshihiro Shioi; Hiromu Suzuki; Minoru Toyota; Eiichiro Yamamoto; Hiroyuki Yamamoto; Yasushi Adachi; Risaburo Akasaka; Masami Ashida; Taku Harada; Kohzoh Imai; Fumio Itoh; Masahiro Kai; Seiko Kamimae; Reo Maruyama; Masanori Nojima; Tamotsu Sugai
Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization.
Genes, chromosomes & cancer 2013;52(2):140-9.
2012: Eiichiro Yamamoto; Hiro-o Yamano; Kenjiro Yoshikawa; Masami Ashida; Taku Harada; Kohzoh Imai; Masahiro Kai; Seiko Kamimae; Tomoaki Kimura; Reo Maruyama; Masanori Nojima; Yasushi Sasaki; Akiko Sato; Takeshi Sawada; Yasuhisa Shinomura; Tamotsu Sugai; Hiromu Suzuki; Ryo Suzuki; Ryo Takagi; Takashi Tokino; Minoru Toyota
Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype.
The American journal of pathology 2012;181(5):1847-61.
2012: Hiroyuki Takamaru; Takashi Tokino; Minoru Toyota; Eiichiro Yamamoto; Hiroyuki Yamamoto; Hiro-O Yamano; Kenjiro Yoshikawa; Tamotsu Sugai; Hiromu Suzuki; Ryo Suzuki; Masami Ashida; Taku Harada; Kohzoh Imai; Masahiro Kai; Tomoaki Kimura; Reo Maruyama; Masanori Nojima; Yasuhisa Shinomura
Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer.
Cancer prevention research (Philadelphia, Pa.) 2012;5(10):1203-12.
2012: Masahiro Shitani; Hiromu Suzuki; Hideyasu Takagi; Takashi Tokino; Minoru Toyota; Hiroyuki Yamamoto; Noriyuki Akutsu; Koichi Hirata; Kohzoh Imai; Masanori Nojima; Shigeru Sasaki; Yasuhisa Shinomura
Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012;33(5):1307-17.
2012: Lisa Kashima; Hiroaki Mita; Kazuhiro Ogi; Yasushi Sasaki; Miki Shitashige; Hiromu Suzuki; Hiroyoshi Ariga; Masashi Idogawa; Minoru Toyota; Tesshi Yamada; Takashi Tokino
CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation.
The Journal of biological chemistry 2012;287(16):12975-84.
2012: Takeshi Niinuma; Toshirou Nishida; Yasunori Nishida; Takayuki Nobuoka; Masanori Nojima; Katsuhiko Nosho; Satoshi Okahara; Yoichi Ajioka; Takeo Bamba; Tadashi Hasegawa; Koichi Hirata; Masao Hosokawa; Kohzoh Imai; Tatsuo Kanda; Reo Maruyama; Yasuaki Miyazaki; Hiromu Suzuki; Takahiro Taguchi; Hiroaki Takahashi; Hiroyuki Takamaru; Takashi Tokino; Minoru Toyota; Eiichiro Yamamoto; Hiroyuki Yamamoto; Yasuhisa Shinomura
Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.
Cancer research 2012;72(5):1126-36.
2011: Yasushi Sasaki; Hiromu Suzuki; Minoru Toyota; Ikuko Yokota; Masahiro Fujita; Masashi Idogawa; Ryota Koyama; Masanobu Kusano; Reo Maruyama; Hideaki Negishi; Tsuyoshi Saito; Takashi Tokino
p53 negatively regulates the hepatoma growth factor HDGF.
Cancer research 2011;71(22):7038-47.
2011: Seiko Kamimae; Eiichiro Yamamoto; Hiro-o Yamano; Masanori Nojima; Hiromu Suzuki; Masami Ashida; Tomo Hatahira; Akiko Sato; Tomoaki Kimura; Kenjiro Yoshikawa; Taku Harada; Seiko Hayashi; Hiroyuki Takamaru; Reo Maruyama; Masahiro Kai; Morie Nishiwaki; Tamotsu Sugai; Yasushi Sasaki; Takashi Tokino; Yasuhisa Shinomura; Kohzoh Imai; Minoru Toyota
Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.
Cancer prevention research (Philadelphia, Pa.) 2011;4(5):674-83.
2011: Shigeru Sasaki; Tadao Ishida; Minoru Toyota; Akinobu Ota; Hiromu Suzuki; Akinori Takaoka; Hiroshi Yasui; Hiroyuki Yamamoto; Hideyasu Takagi; Masahiro Maeda; Tsutomu Seito; Masayuki Tsujisaki; Yasuhisa Shinomura; Kohzoh Imai
Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo.
PloS one 2011;6(5):e19618.
2011: Eiichiro Yamamoto; Hiromu Suzuki; Hiroyuki Takamaru; Hiroyuki Yamamoto; Minoru Toyota; Yasuhisa Shinomura
Role of DNA methylation in the development of diffuse-type gastric cancer.
Digestion 2011;83(4):241-9.
2010: Hiromu Suzuki; Eiichiro Yamamoto; Masanori Nojima; Masahiro Kai; Hiro-O Yamano; Kenjiro Yoshikawa; Tomoaki Kimura; Toyoki Kudo; Eiji Harada; Tamotsu Sugai; Hiroyuki Takamaru; Takeshi Niinuma; Reo Maruyama; Hiroyuki Yamamoto; Takashi Tokino; Kohzoh Imai; Minoru Toyota; Yasuhisa Shinomura
Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect.
Carcinogenesis 2010;31(12):2066-73.
2010: Shinichi Igarashi; Hiromu Suzuki; Takeshi Niinuma; Haruo Shimizu; Masanori Nojima; Hiroyuki Iwaki; Takayuki Nobuoka; Toshirou Nishida; Yasuaki Miyazaki; Hiroyuki Takamaru; Eiichiro Yamamoto; Hiroyuki Yamamoto; Takashi Tokino; Tadashi Hasegawa; Koichi Hirata; Kohzoh Imai; Minoru Toyota; Yasuhisa Shinomura
A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointestinal stromal tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(21):5114-23.
2010: Minoru Toyota; Hiromu Suzuki; Takahiro Nishizaka; Akiko Sato; Toshiharu Yamashita
[Molecular mechanisms involved in epigenetic alterations in cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 2010;37(9):1650-3.
2010: Minoru Toyota; Hiromu Suzuki; Masahiro Kai
[Disease and epigenome analysis].
Seikagaku. The Journal of Japanese Biochemical Society 2010;82(8):693-701.
2010: Tomoko Fujikane; Noriko Nishikawa; Minoru Toyota; Hiromu Suzuki; Masanori Nojima; REO MARUYAMA; Masami Ashida; Mutsumi Ohe-Toyota; Masahiro Kai; Toshihiko Nishidate; Yasushi Sasaki; Tousei Ohmura; Koichi Hirata; Takashi Tokino
Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
Breast cancer research and treatment 2010;122(3):699-710.
2010: Minoru Toyota; Hiromu Suzuki
Epigenetic drivers of genetic alterations.
Advances in genetics 2010;70():309-23.
2009: Minoru Toyota; Eiichiro Yamamoto; Hiroo Yamano; Kohzoh Imai; Hiromu Suzuki; Yasuhisa Shinomura
Integrated analysis of genetic and epigenetic alterations in cancer.
Epigenomics 2009;1(2):291-9.
2009: L Kashima; Minoru Toyota; Hiroaki Mita; Hiromu Suzuki; Masashi Idogawa; K Ogi; Yasushi Sasaki; Takashi Tokino
CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB.
Oncogene 2009;28(29):2643-53.
2009: Masanori Nojima; REO MARUYAMA; Hiroshi Yasui; Hiromu Suzuki; Yumiko Maruyama; Isao Tarasawa; Yasushi Sasaki; Hideki Asaoku; Hajime Sakai; Toshiaki Hayashi; Mitsuru Mori; Kohzoh Imai; Takashi Tokino; Tadao Ishida; Minoru Toyota; Yasuhisa Shinomura
Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4356-64.
2009: Yasushi Sasaki; Hideaki Negishi; Ryota Koyama; Naoki Anbo; Kanae Ohori; Masashi Idogawa; Hiroaki Mita; Minoru Toyota; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino
p53 family members regulate the expression of the apolipoprotein D gene.
The Journal of biological chemistry 2009;284(2):872-83.
2009: Hiroaki Mita; Minoru Toyota; Fumio Aoki; Hirofumi Akashi; REO MARUYAMA; Yasushi Sasaki; Hiromu Suzuki; Masashi Idogawa; Lisa Kashima; Kazuyoshi Yanagihara; Masahiro Fujita; Masao Hosokawa; Masanobu Kusano; Sorin Vasile Sabau; Haruyuki Tatsumi; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino
A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.
BMC cancer 2009;9():198.
2009: Hiromu Suzuki; Minoru Toyota; Yutaka Kondo; Yasuhisa Shinomura
Inflammation-related aberrant patterns of DNA methylation: detection and role in epigenetic deregulation of cancer cell transcriptome.
Methods in molecular biology (Clifton, N.J.) 2009;512():55-69.
2008: Eiichiro Yamamoto; Minoru Toyota; Hiromu Suzuki; Yutaka Kondo; Tamana Sanomura; Yoko Murayama; Mutsumi Ohe-Toyota; REO MARUYAMA; Masanori Nojima; Masami Ashida; Kyoko Fujii; Yasushi Sasaki; Norio Hayashi; Mitsuru Mori; Kohzoh Imai; Takashi Tokino; Yasuhisa Shinomura
LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(10):2555-64.
2008: REO MARUYAMA; Kimishige Akino; Minoru Toyota; Hiromu Suzuki; Takashi Imai; Mutsumi Ohe-Toyota; Eiichiro Yamamoto; Masanori Nojima; Tomoko Fujikane; Yasushi Sasaki; Toshiharu Yamashita; Yoshiyuki Watanabe; Hiroyoshi Hiratsuka; Koichi Hirata; Fumio Itoh; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino
Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.
Carcinogenesis 2008;29(7):1312-8.
2008: Minoru Toyota; Hiromu Suzuki; Yasushi Sasaki; REO MARUYAMA; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino
Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.
Cancer research 2008;68(11):4123-32.
2008: Yohei Sogabe; Hiromu Suzuki; Minoru Toyota; Kazuhiro Ogi; Takashi Imai; Masanori Nojima; Yasushi Sasaki; Hiroyoshi Hiratsuka; Takashi Tokino
Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma.
International journal of oncology 2008;32(6):1253-61.
2008: Takashi Imai; Minoru Toyota; Hiromu Suzuki; Kimishige Akino; Kazuhiro Ogi; Yohei Sogabe; Lisa Kashima; REO MARUYAMA; Masanori Nojima; Hiroaki Mita; Yasushi Sasaki; Fumio Itoh; Kohzoh Imai; Yasuhisa Shinomura; Hiroyoshi Hiratsuka; Takashi Tokino
Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.
Cancer science 2008;99(5):958-66.
2008: Angela H Ting; Hiromu Suzuki; Leslie Cope; Kornel E Schuebel; Byron H Lee; Minoru Toyota; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino; Stephen B Baylin
A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.
Cancer research 2008;68(8):2570-5.
2008: Yasushi Sasaki; Hideaki Negishi; Masashi Idogawa; Hiromu Suzuki; Hiroaki Mita; Minoru Toyota; Yasuhisa Shinomura; Kohzoh Imai; Takashi Tokino
Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models.
Molecular cancer therapeutics 2008;7(4):779-87.
2008: Hiromu Suzuki; Minoru Toyota; Hetty Carraway; H Caraway; Edward Gabrielson; T Ohmura; T Fujikane; Noriko Nishikawa; Y Sogabe; M Nojima; Tomoko Sonoda; M Mori; Koichi Hirata; Kohzoh Imai; Yasuhisa Shinomura; Stephen B Baylin; Takashi Tokino
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.
British journal of cancer 2008;98(6):1147-56.
2008: Yasushi Sasaki; Yuichiro Oshima; Ryota Koyama; REO MARUYAMA; Hirofumi Akashi; Hiroaki Mita; Minoru Toyota; Yasuhisa Shinomura; Kohzoh Imai; Takashi Tokino
Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members.
Molecular cancer research : MCR 2008;6(3):395-406.
2008: Hideyasu Takagi; Shigeru Sasaki; Hiromu Suzuki; Minoru Toyota; REO MARUYAMA; Masanori Nojima; Hiroyuki Yamamoto; Masao Omata; Takashi Tokino; Kohzoh Imai; Yasuhisa Shinomura
Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.
Journal of gastroenterology 2008;43(5):378-89.
2007: Hironobu Sato; Hiromu Suzuki; Minoru Toyota; Masanori Nojima; REO MARUYAMA; Shigeru Sasaki; Hideyasu Takagi; Yohei Sogabe; Yasushi Sasaki; Masashi Idogawa; Tomoko Sonoda; Mitsuru Mori; Kohzoh Imai; Takashi Tokino; Yasuhisa Shinomura
Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.
Carcinogenesis 2007;28(12):2459-66.
2007: Noriko Nishikawa; Minoru Toyota; Hiromu Suzuki; Toshio Honma; Tomoko Fujikane; Tousei Ohmura; Toshihiko Nishidate; Mutsumi Ohe-Toyota; REO MARUYAMA; Tomoko Sonoda; Yasushi Sasaki; Takeshi Urano; Kohzoh Imai; Koichi Hirata; Takashi Tokino
Gene amplification and overexpression of PRDM14 in breast cancers.
Cancer research 2007;67(20):9649-57.
2007: Kornel E Schuebel; Wei Chen; Leslie Cope; Sabine C Glöckner; Hiromu Suzuki; Joo-Mi Yi; Timothy Chan; Leander Van Neste; Wim van Criekinge; Sandra van den Bosch; Manon van Engeland; Angela H Ting; Kam-Wing Jair; Wayne Yu; Minoru Toyota; Kohzoh Imai; NITA AHUJA; James G Herman; Stephen B Baylin
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.
PLoS genetics 2007;3(9):1709-23.
2007: Hiromu Suzuki; Minoru Toyota; Yasuhisa Shinomura; Kohzoh Imai
Epigenetics in gastroenterological cancer and prospects for translational research.
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2007;104(9):1319-28.
2007: Yoshiyuki Watanabe; Minoru Toyota; Yutaka Kondo; Hiromu Suzuki; Takashi Imai; Mutsumi Ohe-Toyota; REO MARUYAMA; Masanori Nojima; Yasushi Sasaki; Yoshitaka Sekido; Hiroyoshi Hiratsuka; Yasuhisa Shinomura; Kohzoh Imai; Fumio Itoh; Takashi Tokino
PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(16):4786-94.
2007: M Nojima; Hiromu Suzuki; Minoru Toyota; Y Watanabe; REO MARUYAMA; Shigeru Sasaki; Yasushi Sasaki; Hiroaki Mita; Noriko Nishikawa; K Yamaguchi; K Hirata; Fumio Itoh; Takashi Tokino; M Mori; Kohzoh Imai; Yasuhisa Shinomura
Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.
Oncogene 2007;26(32):4699-713.
2007: Yuichiro Oshima; Yasushi Sasaki; Hideaki Negishi; Masashi Idogawa; Minoru Toyota; Toshihiko Yamashita; Takuro Wada; Satoshi Nagoya; Satoshi Kawaguchi; Toshiharu Yamashita; Takashi Tokino
Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.
Cancer biology & therapy 2007;6(7):1058-66.
2007: Kimishige Akino; Minoru Toyota; Hiromu Suzuki; Takashi Imai; REO MARUYAMA; Masanobu Kusano; Noriko Nishikawa; Yoshiyuki Watanabe; Yasushi Sasaki; Tamaki Abe; Eiichiro Yamamoto; Isao Tarasawa; Tomoko Sonoda; Mitsuru Mori; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino
Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.
Cancer science 2007;98(1):88-95.
2006: Toshihisa Kobayashi; Yasushi Sasaki; Yuichiro Oshima; Hiroyuki Yamamoto; Hiroaki Mita; Hiromu Suzuki; Minoru Toyota; Takashi Tokino; Fumio Itoh; Kohzoh Imai; Yasuhisa Shinomura
Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.
International journal of molecular medicine 2006;18(1):161-70.
2006: REO MARUYAMA; Fumio Aoki; Minoru Toyota; Yasushi Sasaki; Hirofumi Akashi; Hiroaki Mita; Hiromu Suzuki; Kimishige Akino; Mutsumi Ohe-Toyota; Yumiko Maruyama; Haruyuki Tatsumi; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino
Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.
Cancer research 2006;66(9):4574-83.
2006: Hiromu Suzuki; Minoru Toyota; Hironobu Sato; Tomoko Sonoda; Fumio Sakauchi; Mitsuru Mori
Roles and causes of abnormal DNA methylation in gastrointestinal cancers.
Asian Pacific journal of cancer prevention : APJCP 2006;7(2):177-85.
2006: Masanobu Kusano; Minoru Toyota; Hiromu Suzuki; Kimishige Akino; Fumio Aoki; Masahiro Fujita; Masao Hosokawa; Yasuhisa Shinomura; Kohzoh Imai; Takashi Tokino
Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus.
Cancer 2006;106(7):1467-79.
2006: Katsuhiko Terasawa; Minoru Toyota; Satoru Sagae; Kazuhiro Ogi; Hiromu Suzuki; Tomoko Sonoda; Kimishige Akino; REO MARUYAMA; Noriko Nishikawa; Kohzoh Imai; Yasuhisa Shinomura; T Saito; Takashi Tokino
Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines.
British journal of cancer 2006;94(6):914-21.
2005: Minoru Toyota; Jean-Pierre J Issa
Epigenetic changes in solid and hematopoietic tumors.
Seminars in oncology 2005;32(5):521-30.
2005: Hiroshi Ikeda; Yasushi Sasaki; Toshihisa Kobayashi; Hiromu Suzuki; Hiroaki Mita; Minoru Toyota; Fumio Itoh; Yasuhisa Shinomura; Takashi Tokino; Kohzoh Imai
The role of T-fimbrin in the response to DNA damage: silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents.
International journal of oncology 2005;27(4):933-40.
2005: Kazuhiro Ogi; Minoru Toyota; Hiroaki Mita; Ayumi Satoh; Lisa Kashima; Yasushi Sasaki; Hiromu Suzuki; Kimishige Akino; Noriko Nishikawa; Makoto Noguchi; Yasuhisa Shinomura; Kohzoh Imai; Hiroyoshi Hiratsuka; Takashi Tokino
Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors.
Cancer biology & therapy 2005;4(7):773-80.
2005: Kimishige Akino; Minoru Toyota; Hiromu Suzuki; Hiroaki Mita; Yasushi Sasaki; Mutsumi Ohe-Toyota; Jean-Pierre J Issa; Yuji Hinoda; Kohzoh Imai; Takashi Tokino
The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer.
Gastroenterology 2005;129(1):156-69.
2005: Tamaki Abe; Minoru Toyota; Hiromu Suzuki; Masafumi Murai; Kimishige Akino; Masako Ueno; Masanori Nojima; Atsushi Yawata; Hiroyuki Miyakawa; Toshihiro Suga; Hideto Ito; Takao Endo; Takashi Tokino; Yuji Hinoda; Kohzoh Imai
Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.
Journal of gastroenterology 2005;40(5):504-10.
2005: Hideto Ito; Takao Endo; Toshikuni Oka; Takeshi Matumoto; Tamaki Abe; Minoru Toyota; Kohzoh Imai; Masaaki Satoh; Hiroyuki Maguchi; Toshiya Shinohara
Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas.
Pancreas 2005;30(4):e96-102.
2005: Hiromu Suzuki; Minoru Toyota; Masanori Nojima; Mitsuru Mori; Kohzoh Imai
[SFRP, a family of new colorectal tumor suppressor candidate genes].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(4):707-19.
2005: Masafumi Murai; Minoru Toyota; Ayumi Satoh; Hiromu Suzuki; Kimishige Akino; Hiroaki Mita; Yasushi Sasaki; T Ishida; L Shen; G Garcia-Manero; Jean-Pierre J Issa; Yuji Hinoda; Takashi Tokino; Kohzoh Imai
Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.
British journal of cancer 2005;92(6):1165-72.
2005: Masafumi Murai; Minoru Toyota; Hiromu Suzuki; Ayumi Satoh; Yasushi Sasaki; Kimishige Akino; Masako Ueno; Fumihiko Takahashi; Masanobu Kusano; Hiroaki Mita; Kazuyoshi Yanagihara; Takao Endo; Yuji Hinoda; Takashi Tokino; Kohzoh Imai
Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1021-7.
2004: Ayumi Satoh; Minoru Toyota; Hideyuki Ikeda; Yoshikazu Morimoto; Kimishige Akino; Hiroaki Mita; Hiromu Suzuki; Yasushi Sasaki; Takayuki Kanaseki; Yukio Takamura; Hidenobu Soejima; Takeshi Urano; Kazuyoshi Yanagihara; Takao Endo; Yuji Hinoda; Masahiro Fujita; Masao Hosokawa; Noriyuki Sato; Takashi Tokino; Kohzoh Imai
Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells.
Oncogene 2004;23(55):8876-86.
2004: Katsuya Adachi; Minoru Toyota; Yasushi Sasaki; Toshiharu Yamashita; Setsuko Ishida; Mutsumi Ohe-Toyota; REO MARUYAMA; Yuji Hinoda; Tsuyoshi Saito; Kohzoh Imai; Ryuichi Kudo; Takashi Tokino
Identification of SCN3B as a novel p53-inducible proapoptotic gene.
Oncogene 2004;23(47):7791-8.
2004: Masako Ueno; Minoru Toyota; Kimishige Akino; Hiromu Suzuki; Masanobu Kusano; Ayumi Satoh; Hiroaki Mita; Yasushi Sasaki; Masanori Nojima; Kazuyoshi Yanagihara; Yuji Hinoda; Takashi Tokino; Kohzoh Imai
Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2004;25(3):134-40.
2004: Hiromu Suzuki; DAVID WATKINS; Kam-Wing Jair; Kornel E Schuebel; Sanford D Markowitz; Wei Dong Chen; Theresa P Pretlow; Bin Yang; Yoshimitsu Akiyama; Manon van Engeland; Minoru Toyota; Takashi Tokino; Yuji Hinoda; Kohzoh Imai; James G Herman; Stephen B Baylin
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.
Nature genetics 2004;36(4):417-22.
2004: Katsuhiko Terasawa; Satoru Sagae; Minoru Toyota; Kuniko Tsukada; Kazuhiro Ogi; Ayumi Satoh; Hiroaki Mita; Kohzoh Imai; Takashi Tokino; Ryuichi Kudo
Epigenetic inactivation of TMS1/ASC in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):2000-6.
2004: Yukio Takamura; Hideyuki Ikeda; Takayuki Kanaseki; Minoru Toyota; Takashi Tokino; Kohzoh Imai; Kiyohiro Houkin; Noriyuki Sato
Regulation of MHC class II expression in glioma cells by class II transactivator (CIITA).
Glia 2004;45(4):392-405.
2004: Y Morimoto; Minoru Toyota; Ayumi Satoh; Masafumi Murai; Hiroaki Mita; Hiromu Suzuki; Yukio Takamura; Hideyuki Ikeda; T Ishida; Noriyuki Sato; Takashi Tokino; Kohzoh Imai
Inactivation of class II transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon-gamma in haematopoietic tumour cells.
British journal of cancer 2004;90(4):844-52.
2004: Takao Endo; Minoru Toyota; Kohzoh Imai
Silencing of negative regulator of JAK/STAT in colorectal cancer.
Journal of gastroenterology 2004;39(2):200-1.
2003: Ayumi Satoh; Minoru Toyota; Fumio Itoh; Yasushi Sasaki; Hiromu Suzuki; Kazuhiro Ogi; Takefumi Kikuchi; Hiroaki Mita; Toshiharu Yamashita; Takashi Kojima; Masanobu Kusano; Masahiro Fujita; Masao Hosokawa; Takao Endo; Takashi Tokino; Kohzoh Imai
Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.
Cancer research 2003;63(24):8606-13.
2003: Toshiro Obata; Minoru Toyota; Ayumi Satoh; Yasushi Sasaki; Kazuhiro Ogi; Kimishige Akino; Hiromu Suzuki; Masafumi Murai; Takefumi Kikuchi; Hiroaki Mita; Fumio Itoh; Jean-Pierre J Issa; Takashi Tokino; Kohzoh Imai
Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6410-8.
2003: Yasushi Sasaki; Hiroaki Mita; Minoru Toyota; Setsuko Ishida; Ichiro Morimoto; Toshiharu Yamashita; Toshihiro Tanaka; Kohzoh Imai; Yusuke Nakamura; Takashi Tokino
Identification of the interleukin 4 receptor alpha gene as a direct target for p73.
Cancer research 2003;63(23):8145-52.
2003: Minoru Toyota; Yasushi Sasaki; Ayumi Satoh; Kazuhiro Ogi; Takefumi Kikuchi; Hiromu Suzuki; Hiroaki Mita; Nobuyuki Tanaka; Fumio Itoh; Jean-Pierre J Issa; Kam-Wing Jair; Kornel E Schuebel; Kohzoh Imai; Takashi Tokino
Epigenetic inactivation of CHFR in human tumors.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7818-23.
2003: Takayuki Kanaseki; Hideyuki Ikeda; Yukio Takamura; Minoru Toyota; Yoshihiko Hirohashi; Takashi Tokino; Tetsuo Himi; Noriyuki Sato
Histone deacetylation, but not hypermethylation, modifies class II transactivator and MHC class II gene expression in squamous cell carcinomas.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):4980-5.
2002: Minoru Toyota; Fumio Itoh; Takefumi Kikuchi; Ayumi Satoh; Toshiro Obata; Hiromu Suzuki; Suguru Ishii; Takao Endo; Takashi Tokino; Kohzoh Imai
DNA methylation changes in gastrointestinal disease.
Journal of gastroenterology 2002;37 Suppl 14():97-101.
2002: Kazuhiro Ogi; Minoru Toyota; Mutsumi Ohe-Toyota; Nobuyuki Tanaka; Makoto Noguchi; Tomoko Sonoda; Geniku Kohama; Takashi Tokino
Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(10):3164-71.
2002: Ayumi Satoh; Minoru Toyota; Fumio Itoh; T Kikuchi; T Obata; Yasushi Sasaki; Hiromu Suzuki; Atsushi Yawata; M Kusano; M Fujita; M Hosokawa; K Yanagihara; Takashi Tokino; Kohzoh Imai
DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers.
British journal of cancer 2002;86(11):1817-23.
2002: Takefumi Kikuchi; Minoru Toyota; Fumio Itoh; Hiromu Suzuki; Toshiro Obata; Hiroyuki Yamamoto; Hideki Kakiuchi; Masanobu Kusano; Jean-Pierre J Issa; Takashi Tokino; Kohzoh Imai
Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors.
Oncogene 2002;21(17):2741-9.
2002: Takefumi Kikuchi; Fumio Itoh; Minoru Toyota; Hiromu Suzuki; Hiroyuki Yamamoto; Masahiro Fujita; Masao Hosokawa; Kohzoh Imai
Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer.
International journal of cancer. Journal international du cancer 2002;97(3):272-7.
2002: Yasushi Sasaki; Fumio Itoh; Toshihisa Kobayashi; Takefumi Kikuchi; Hiromu Suzuki; Minoru Toyota; Kohzoh Imai
Increased expression of T-fimbrin gene after DNA damage in CHO cells and inactivation of T-fimbrin by CpG methylation in human colorectal cancer cells.
International journal of cancer. Journal international du cancer 2002;97(2):211-6.
2001: Hiroyuki Kaneto; Shigeru Sasaki; Hiroyuki Yamamoto; Fumio Itoh; Minoru Toyota; Hiromu Suzuki; Itaru Ozeki; N Iwata; Takumi Ohmura; T Satoh; Yoshiyasu Karino; T Satoh; Jouji Toyota; Masaaki Satoh; Toshiaki Endo; M Omata; Kohzoh Imai
Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus.
Gut 2001;48(3):372-7.
2000: Hiroaki Mita; Fumio Itoh; Minoru Toyota; Yuji Hinoda; S Imai; Kohzoh Imai
Isolation of the Epstein-Barr virus in scirrhous gastric cancer by efficiency-monitored representational difference analysis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2000;21(5):249-57.
2000: Hiromu Suzuki; Fumio Itoh; Minoru Toyota; Takefumi Kikuchi; Hideki Kakiuchi; Kohzoh Imai
Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers.
Cancer research 2000;60(16):4353-7.
2000: Hiromu Suzuki; Fumio Itoh; Minoru Toyota; Takefumi Kikuchi; Hideki Kakiuchi; Yuji Hinoda; Kohzoh Imai
Quantitative DNA methylation analysis by fluorescent polymerase chain reaction single-strand conformation polymorphism using an automated DNA sequencer.
Electrophoresis 2000;21(5):904-8.
2000: Minoru Toyota; M Ohe-Toyota; NITA AHUJA; Jean-Pierre J Issa
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):710-5.
2000: Minoru Toyota; Fumio Itoh; Kohzoh Imai
DNA methylation and gastrointestinal malignancies: functional consequences and clinical implications.
Journal of gastroenterology 2000;35(10):727-34.
2000: M Esteller; Silvia Tortola; Minoru Toyota; G Capella; Miguel A Peinado; Stephen B Baylin; James G Herman
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.
Cancer research 2000;60(1):129-33.
1999: Minoru Toyota; NITA AHUJA; H Suzuki; F Itoh; M Ohe-Toyota; K Imai; Stephen B Baylin; Jean-Pierre J Issa
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.
Cancer research 1999;59(21):5438-42.
1999: Hiromu Suzuki; Fumio Itoh; Minoru Toyota; Takefumi Kikuchi; Hideki Kakiuchi; Yuji Hinoda; Kohzoh Imai
Distinct methylation pattern and microsatellite instability in sporadic gastric cancer.
International journal of cancer. Journal international du cancer 1999;83(3):309-13.
1999: Minoru Toyota; Jean-Pierre J Issa
CpG island methylator phenotypes in aging and cancer.
Seminars in cancer biology 1999;9(5):349-57.
1999: Minoru Toyota; C Ho; M Ohe-Toyota; Stephen B Baylin; Jean-Pierre J Issa
Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors.
Cancer research 1999;59(18):4535-41.
1999: Minoru Toyota; NITA AHUJA; M Ohe-Toyota; James G Herman; Stephen B Baylin; Jean-Pierre J Issa
CpG island methylator phenotype in colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8681-6.
1999: Minoru Toyota; C Ho; NITA AHUJA; Kam-Wing Jair; Qing Li; M Ohe-Toyota; Stephen B Baylin; Jean-Pierre J Issa
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.
Cancer research 1999;59(10):2307-12.
1997: AS Takaoka; Minoru Toyota; Yuji Hinoda; Fumio Itoh; Hiroaki Mita; Hideki Kakiuchi; Masaaki Adachi; Kohzoh Imai
Expression and identification of aberrant c-kit transcripts in human cancer cells.
Cancer letters 1997;115(2):257-61.
1996: Minoru Toyota; Y Hinoda; N Nakagawa; Yoshiaki Arimura; S Tokuchi; AS Takaoka; S Kitagawa; T Usuki; T Yabana; A Yachi; K Imai
Gastric antral vascular ectasia causing severe anemia.
Journal of gastroenterology 1996;31(5):710-3.
1994: S Ikuta; Fumio Itoh; Y Hinoda; Minoru Toyota; Yusuke Makiguchi; K Imai; A Yachi
Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma.
Journal of gastroenterology 1994;29(6):727-32.
1994: Minoru Toyota; Y Hinoda; Fumio Itoh; AS Takaoka; K Imai; A Yachi
Complementary DNA cloning and characterization of truncated form of c-kit in human colon carcinoma cells.
Cancer research 1994;54(1):272-5.
1993: Minoru Toyota; Y Hinoda; AS Takaoka; Yusuke Makiguchi; T Takahashi; Fumio Itoh; K Imai; A Yachi
Expression of c-kit and kit ligand in human colon carcinoma cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1993;14(5):295-302.
1992: Minoru Toyota; Y Hinoda; Fumio Itoh; Masayuki Tsujisaki; K Imai; A Yachi
Expression of two types of kit ligand mRNAs in human tumor cells.
International journal of hematology 1992;55(3):301-4.