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Frank Traganos

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Elise McKenna; Frank Traganos; Hong Zhao; Zbigniew Darzynkiewicz
Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence.
H Dorota Halicka; Jiangwei Li; George P Studzinski; Frank Traganos; Hong Zhao; Zbigniew Darzynkiewicz
Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3.
Hong Zhao; Jurek Dobrucki; H Dorota Halicka; Paulina Rybak; Frank Traganos; Zbigniew Darzynkiewicz
Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".

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All Publications

2012: Elise McKenna; Frank Traganos; Hong Zhao; Zbigniew Darzynkiewicz
Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence.
Cell cycle (Georgetown, Tex.) 2012;11(16):3132-40.
2012: H Dorota Halicka; Jiangwei Li; George P Studzinski; Frank Traganos; Hong Zhao; Zbigniew Darzynkiewicz
Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3.
Aging 2012;4(4):270-8.
2011: Hong Zhao; Jurek Dobrucki; H Dorota Halicka; Paulina Rybak; Frank Traganos; Zbigniew Darzynkiewicz
Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(11):897-902.
2011: H Dorota Halicka; Marietta Lee; Jiangwei Li; Frank Traganos; Sufang Zhang; Hong Zhao; Zbigniew Darzynkiewicz
Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling.
Aging 2011;3(10):1028-38.
2011: Hong Zhao; Jiangwei Li; Frank Traganos; H Dorota Halicka; Mirosław Zarebski; Jurek Dobrucki; Zbigniew Darzynkiewicz
Cell fixation in zinc salt solution is compatible with DNA damage response detection by phospho-specific antibodies.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(6):470-6.
2011: Zbigniew Darzynkiewicz; Frank Traganos; Hong Zhao; H Dorota Halicka; Jiangwei Li
Cytometry of DNA replication and RNA synthesis: Historical perspective and recent advances based on "click chemistry".
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(5):328-37.
2011: Zbigniew Darzynkiewicz; H Dorota Halicka; Joanna Skommer; Frank Traganos; Hong Zhao; Donald Wlodkowic
Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry.
Methods in cell biology 2011;103():115-47.
2010: Hong Zhao; H Dorota Halicka; Frank Traganos; Ellen Jorgensen; Zbigniew Darzynkiewicz
New biomarkers probing depth of cell senescence assessed by laser scanning cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010;77(11):999-1007.
2010: Ellen D Jorgensen; Hong Zhao; Frank Traganos; Anthony P Albino; Zbigniew Darzynkiewicz
DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes.
Cell cycle (Georgetown, Tex.) 2010;9(11):2170-6.
2010: Maki Ikeda; Akira Kurose; Eriko Takatori; Toru Sugiyama; Frank Traganos; Zbigniew Darzynkiewicz; Takashi Sawai
DNA damage detected with gammaH2AX in endometrioid adenocarcinoma cell lines.
International journal of oncology 2010;36(5):1081-8.
2010: Hong Zhao; Frank Traganos; Zbigniew Darzynkiewicz
Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2010;77(3):285-93.
2010: Kazuhito Oka; Toshiki Tanaka; Tadahiko Enoki; Koichi Yoshimura; Mako Ohshima; Masayuki Kubo; Tomoyuki Murakami; Toshikazu Gondou; Yoshihide Minami; Yoshihiro Takemoto; Eijirou Harada; Takaaki Tsushimi; Tao-Sheng Li; Frank Traganos; Zbigniew Darzynkiewicz; Kimikazu Hamano
DNA damage signaling is activated during cancer progression in human colorectal carcinoma.
Cancer biology & therapy 2010;9(3):246-52.
2009: Zbigniew Darzynkiewicz; Frank Traganos; Donald Wlodkowic
Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.
European journal of pharmacology 2009;625(1-3):143-50.
2009: Hong Zhao; Anthony P Albino; Ellen Jorgensen; Frank Traganos; Zbigniew Darzynkiewicz
DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(10):840-7.
2009: Anthony P Albino; Ellen D Jorgensen; Patrick Rainey; Gene Gillman; T Jeffrey Clark; Diana Gietl; Hong Zhao; Frank Traganos; Zbigniew Darzynkiewicz
gammaH2AX: A potential DNA damage response biomarker for assessing toxicological risk of tobacco products.
Mutation research 2009;678(1):43-52.
2009: H Dorota Halicka; Hong Zhao; Monika Podhorecka; Frank Traganos; Zbigniew Darzynkiewicz
Cytometric detection of chromatin relaxation, an early reporter of DNA damage response.
Cell cycle (Georgetown, Tex.) 2009;8(14):2233-7.
2009: H Dorota Halicka; Daniel J Smart; Frank Traganos; Gary M Williams; Zbigniew Darzynkiewicz
Fluoroquinolones lower constitutive H2AX and ATM phosphorylation in TK6 lymphoblastoid cells via modulation of the intracellular redox status.
Pharmacological reports : PR 2009;61(4):711-8.
2009: H Dorota Halicka; M Fevzi Ozkaynak; Oya Levendoglu-Tugal; Claudio Sandoval; Karen Seiter; Malgorzata Kajstura; Frank Traganos; Somasunadaram Jayabose; Zbigniew Darzynkiewicz
DNA damage response as a biomarker in treatment of leukemias.
Cell cycle (Georgetown, Tex.) 2009;8(11):1720-4.
2009: Hong Zhao; Frank Traganos; Jurek Dobrucki; Donald Wlodkowic; Zbigniew Darzynkiewicz
Induction of DNA damage response by the supravital probes of nucleic acids.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(6):510-9.
2009: Yuichi Sato; Akira Kurose; Akira Ogawa; Kuniaki Ogasawara; Frank Traganos; Zbigniew Darzynkiewicz; Takashi Sawai
Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide.
Cancer biology & therapy 2009;8(5):452-7.
2009: Toshiki Tanaka; Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs).
Methods in molecular biology (Clifton, N.J.) 2009;523():161-8.
2008: Hong Zhao; Frank Traganos; Zbigniew Darzynkiewicz
Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation.
Cell cycle (Georgetown, Tex.) 2008;7(19):3048-55.
2008: Hong Zhao; Frank Traganos; Zbigniew Darzynkiewicz
Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(6):480-9.
2008: Hong Zhao; Frank Traganos; Anthony P Albino; Zbigniew Darzynkiewicz
Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation.
Cell cycle (Georgetown, Tex.) 2008;7(10):1490-5.
2008: Daniel J Smart; H Dorota Halicka; Gabriele Schmuck; Frank Traganos; Zbigniew Darzynkiewicz; Gary M Williams
Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone.
Mutation research 2008;641(1-2):43-7.
2008: Sophie Chen; Jian Gao; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
Down-regulation of androgen-receptor and PSA by phytochemicals.
International journal of oncology 2008;32(2):405-11.
2008: Daniel J Smart; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz; Gary M Williams
Ciprofloxacin-induced G2 arrest and apoptosis in TK6 lymphoblastoid cells is not dependent on DNA double-strand break formation.
Cancer biology & therapy 2008;7(1):113-9.
2007: Tze-Chen Hsieh; Frank Traganos; Zbigniew Darzynkiewicz; Joseph Wu
The 2,6-disubstituted purine reversine induces growth arrest and polyploidy in human cancer cells.
International journal of oncology 2007;31(6):1293-300.
2007: Hong Zhao; Toshiki Tanaka; H Dorota Halicka; Frank Traganos; Miroslaw Zarebski; Jurek Dobrucki; Zbigniew Darzynkiewicz
Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(11):905-14.
2007: Toshiki Tanaka; Xuan Huang; H Dorota Halicka; Hong Zhao; Frank Traganos; Anthony P Albino; Wei Dai; Zbigniew Darzynkiewicz
Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(9):648-61.
2007: Toshiki Tanaka; H Dorota Halicka; Frank Traganos; Karen Seiter; Zbigniew Darzynkiewicz
Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase.
Cell cycle (Georgetown, Tex.) 2007;6(3):371-6.
2007: Toshiki Tanaka; M Kajstura; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
Cell proliferation 2007;40(1):1-13.
2007: Toshiki Tanaka; Xuan Huang; Ellen Jorgensen; Diana Gietl; Frank Traganos; Zbigniew Darzynkiewicz; Anthony P Albino
ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.
BMC cell biology 2007;8():26.
2006: Toshiki Tanaka; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes.
Cell cycle (Georgetown, Tex.) 2006;5(22):2671-5.
2006: Toshiki Tanaka; H Dorota Halicka; Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants.
Cell cycle (Georgetown, Tex.) 2006;5(17):1940-5.
2006: Toshiki Tanaka; Akira Kurose; Xuan Huang; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status.
Cell proliferation 2006;39(4):313-23.
2006: Toshiki Tanaka; Akira Kurose; H Dorota Halicka; Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: involvement of reactive oxygen species.
Cell cycle (Georgetown, Tex.) 2006;5(15):1669-74.
2006: Xuan Huang; Toshiki Tanaka; Akira Kurose; Frank Traganos; Zbigniew Darzynkiewicz
Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species.
International journal of oncology 2006;29(2):495-501.
2006: Xuan Huang; Akira Kurose; Toshiki Tanaka; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine.
Cancer biology & therapy 2006;5(8):959-64.
2006: Y Fang; T Liu; X Wang; Y-M Yang; H Deng; Jan Kunicki; Frank Traganos; Zbigniew Darzynkiewicz; L Lu; W Dai
BubR1 is involved in regulation of DNA damage responses.
Oncogene 2006;25(25):3598-605.
2006: Anthony P Albino; Xuan Huang; Ellen D Jorgensen; Diana Gietl; Frank Traganos; Zbigniew Darzynkiewicz
Induction of DNA double-strand breaks in A549 and normal human pulmonary epithelial cells by cigarette smoke is mediated by free radicals.
International journal of oncology 2006;28(6):1491-505.
2006: Akira Kurose; Toshiki Tanaka; Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
Synchronization in the cell cycle by inhibitors of DNA replication induces histone H2AX phosphorylation: an indication of DNA damage.
Cell proliferation 2006;39(3):231-40.
2006: Toshiki Tanaka; Akira Kurose; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz
2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX.
Cell cycle (Georgetown, Tex.) 2006;5(8):878-82.
2006: Xuan Huang; Akira Kurose; Toshiki Tanaka; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(4):222-9.
2006: Akira Kurose; Toshiki Tanaka; Xuan Huang; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(4):212-21.
2006: Rakhee S Gupte; Valerie Sampson; Frank Traganos; Zbigniew Darzynkiewicz; Marietta Y W T Lee
Cyclic AMP regulates the expression and nuclear translocation of RFC40 in MCF7 cells.
Experimental cell research 2006;312(6):796-806.
2006: Rakhee S Gupte; Frank Traganos; Zbigniew Darzynkiewicz; Marietta Y W T Lee
Phosphorylation of RIalpha by cyclin-dependent kinase CDK 2/cyclin E modulates the dissociation of the RIalpha-RFC40 complex.
Cell cycle (Georgetown, Tex.) 2006;5(6):653-60.
2005: Akira Kurose; Toshiki Tanaka; Xuan Huang; H Dorota Halicka; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz
Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;68(1):1-9.
2005: Yang-Ming Yang; Meena Jhanwar-Uniyal; Joel L. Schwartz; C Clifford Conaway; H Dorota Halicka; Frank Traganos; Fung-Lung Chung
N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells.
Cancer research 2005;65(18):8538-47.
2005: Xuan Huang; H Dorota Halicka; Frank Traganos; Toshiki Tanaka; Akira Kurose; Zbigniew Darzynkiewicz
Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis.
Cell proliferation 2005;38(4):223-43.
2005: Rakhee S Gupte; Piotr Pozarowski; Jerzy Grabarek; Frank Traganos; Zbigniew Darzynkiewicz; Marietta Y W T Lee
RIalpha influences cellular proliferation in cancer cells by transporting RFC40 into the nucleus.
Cancer biology & therapy 2005;4(4):429-37.
2005: Sophie Chen; Jian Gao; H Dorota Halicka; Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage.
International journal of oncology 2005;26(3):579-88.
2005: H Dorota Halicka; Xuan Huang; Frank Traganos; Malcolm A King; Wei Dai; Zbigniew Darzynkiewicz
Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis.
Cell cycle (Georgetown, Tex.) 2005;4(2):339-45.
2004: Xuan Huang; Malcolm A King; H Dorota Halicka; Frank Traganos; Masaki Okafuji; Zbigniew Darzynkiewicz
Histone H2AX phosphorylation induced by selective photolysis of BrdU-labeled DNA with UV light: relation to cell cycle phase.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;62(1):1-7.
2004: Susan Olson; Richard Oeckler; Xinmei Li; Litong Du; Frank Traganos; Xiangmin Zhao; Theresa Burke-Wolin
Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor.
American journal of physiology. Lung cellular and molecular physiology 2004;287(3):L559-68.
2004: Anthony P Albino; Xuan Huang; Ellen D Jorgensen; J Yang; Diana Gietl; Frank Traganos; Zbigniew Darzynkiewicz
Induction of H2AX phosphorylation in pulmonary cells by tobacco smoke: a new assay for carcinogens.
Cell cycle (Georgetown, Tex.) 2004;3(8):1062-8.
2004: Xin-Hua Zhu; Hoang Nguyen; H Dorota Halicka; Frank Traganos; Andrew Koff
Noncatalytic requirement for cyclin A-cdk2 in p27 turnover.
Molecular and cellular biology 2004;24(13):6058-66.
2004: Xuan Huang; Qin Ruan; Yuqiang Fang; Frank Traganos; Zbigniew Darzynkiewicz; Wei Dai
Physical and functional interactions between mitotic kinases during polyploidization and megakaryocytic differentiation.
Cell cycle (Georgetown, Tex.) 2004;3(7):946-51.
2004: Raymond K Yeh; Jie Chen; Jennie L Williams; Mehdi Baluch; Thomas R Hundley; Raphael E Rosenbaum; Srinivas Kalala; Frank Traganos; Francesca Benardini; Piero Del Soldato; Khosrow Kashfi; Basil Rigas
NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property?
Biochemical pharmacology 2004;67(12):2197-205.
2004: Xuan Huang; Masaki Okafuji; Frank Traganos; Ed Luther; Elena Holden; Zbigniew Darzynkiewicz
Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;58(2):99-110.
2004: Frank Traganos
Mechanism of antitumor drug action assessed by cytometry.
Methods in cell biology 2004;75():257-305.
2004: Frank Traganos
Cycling without cyclins.
Cell cycle (Georgetown, Tex.) 2004;3(1):32-4.
2003: Xuan Huang; Frank Traganos; Zbigniew Darzynkiewicz
DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis.
Cell cycle (Georgetown, Tex.) 2003;2(6):614-9.
2003: Zbigniew Darzynkiewicz; Gloria Juan; Frank Traganos
Cytometry of cell cycle regulatory proteins.
Progress in cell cycle research 2003;5():533-42.
2002: Khosrow Kashfi; Yassir Ryan; Leon L Qiao; Jennie L Williams; Jie Chen; Piero Del Soldato; Frank Traganos; Basil Rigas; Yassir Ryann
Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-independent effect.
The Journal of pharmacology and experimental therapeutics 2002;303(3):1273-82.
2002: Wei Dai; Qi Wang; Frank Traganos
Polo-like kinases and centrosome regulation.
Oncogene 2002;21(40):6195-200.
2002: Giovanni Li Volti; Jishi Wang; Frank Traganos; Attallah Kappas; Nader G Abraham
Differential effect of heme oxygenase-1 in endothelial and smooth muscle cell cycle progression.
Biochemical and biophysical research communications 2002;296(5):1077-82.
2002: Mikhail V Blagosklonny; Robert Robey; Dan L Sackett; Litong Du; Frank Traganos; Zbigniew Darzynkiewicz; Tito Fojo; Susan E Bates
Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.
Molecular cancer therapeutics 2002;1(11):937-41.
2002: Suqing Xie; Qi Wang; Lu Luo; Qin Ruan; Tongyi Liu; Meena Jhanwar-Uniyal; Zbigniew Darzynkiewicz; Frank Traganos; Wei Dai
Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(9):957-63.
2002: Tze-Chen Hsieh; Wen Xiong; Frank Traganos; Zbigniew Darzynkiewicz; Joseph Wu
Effects of PC-SPES on proliferation and expression of AR/PSA in androgen-responsive LNCaP cells are independent of estradiol.
Anticancer research 2002;22(4):2051-60.
2002: H Dorota Halicka; Piotr Smolewski; Zbigniew Darzynkiewicz; Wei Dai; Frank Traganos
Arsenic trioxide arrests cells early in mitosis leading to apoptosis.
Cell cycle (Georgetown, Tex.) 2002;1(3):201-9.
2002: Qi Wang; Suqing Xie; Jie Chen; Kenji Fukasawa; Ulhas Naik; Frank Traganos; Zbigniew Darzynkiewicz; Meena Jhanwar-Uniyal; Wei Dai
Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity.
Molecular and cellular biology 2002;22(10):3450-9.
2001: S Chen; Q Ruan; Elzbieta Bedner; A Deptala; X Wang; Tze-Chen Hsieh; Frank Traganos; Zbigniew Darzynkiewicz
Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines.
Cell proliferation 2001;34(5):293-304.
2001: L Du; Piotr Smolewski; Elzbieta Bedner; Frank Traganos; Zbigniew Darzynkiewicz
Selective protection of mitogenically stimulated human lymphocytes but not leukemic cells from cytosine arabinoside-induced apoptosis by LY294002, a phosphoinositol-3 kinase inhibitor.
International journal of oncology 2001;19(4):811-9.
2001: Barbara Ardelt; Jan Kunicki; Frank Traganos; Zbigniew Darzynkiewicz
Chlorophyllin protects cells from the cytostatic and cytotoxic effects of quinacrine mustard but not of nitrogen mustard.
International journal of oncology 2001;18(4):849-53.
2001: Elzbieta Bedner; Litong Du; Frank Traganos; Zbigniew Darzynkiewicz
Caffeine dissociates complexes between DNA and intercalating dyes: application for bleaching fluorochrome-stained cells for their subsequent restaining and analysis by laser scanning cytometry.
Cytometry 2001;43(1):38-45.
2001: Zbigniew Darzynkiewicz; Gloria Juan; Frank Traganos
Assaying drug-induced apoptosis.
Methods in molecular biology (Clifton, N.J.) 2001;95():241-54.
2001: Frank Traganos; Gloria Juan; Zbigniew Darzynkiewicz
Cell-cycle analysis of drug-treated cells.
Methods in molecular biology (Clifton, N.J.) 2001;95():229-40.
2001: Zbigniew Darzynkiewicz; Elzbieta Bedner; Frank Traganos
Difficulties and pitfalls in analysis of apoptosis.
Methods in cell biology 2001;63():527-46.
2001: Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz
Methods to identify mitotic cells by flow cytometry.
Methods in cell biology 2001;63():343-54.
2000: JS Nair; Frank Traganos; Yuk-Ching Tse-Dinh
Differential effect of camptothecin treatment on topoisomerase II alpha expression in ML-1 and HL-60 leukemia cell lines.
Anticancer research 2000;20(6B):4183-8.
2000: AM DiPietrantonio; Tze-Chen Hsieh; Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz; Joseph Wu
Fenretinide-induced caspase 3 activity involves increased protein stability in a mechanism distinct from reactive oxygen species elevation.
Cancer research 2000;60(16):4331-5.
2000: Anthony P Albino; G Juan; Frank Traganos; L Reinhart; J Connolly; David P Rose; Zbigniew Darzynkiewicz
Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation.
Cancer research 2000;60(15):4139-45.
2000: Eric J Feldman; Karen Seiter; Frank Traganos; Zbigniew Darzynkiewicz; H Goff; M Pozzuoli; Paul Baskind; S Santos; Tauseef Ahmed
Phase II evaluation of a high-dose mitoxantrone based induction regimen in untreated adults with acute myeloid leukemia.
Leukemia & lymphoma 2000;38(3-4):309-15.
2000: C W Lin; Zbigniew Darzynkiewicz; Xuguang Li; Frank Traganos; Elzbieta Bedner; Yuk-Ching Tse-Dinh
Differential expression of human topoisomerase IIIalpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes.
Experimental cell research 2000;256(1):225-36.
2000: JS Nair; Ram Kancherla; Karen Seiter; Frank Traganos; Yuk-Ching Tse-Dinh
Action of topoisomerase targeting drugs on non-Hodgkin's lymphoma and leukemia. Correlation of clinical and cell culture studies.
Annals of the New York Academy of Sciences 2000;922():326-9.
2000: Karen Seiter; Eric J Feldman; H Dorota Halicka; A Deptala; Frank Traganos; Harry B Burke; A Hoang; H Goff; M Pozzuoli; Ram Kancherla; Zbigniew Darzynkiewicz; Tauseef Ahmed
Clinical and laboratory evaluation of all-trans retinoic acid modulation of chemotherapy in patients with acute myelogenous leukaemia.
British journal of haematology 2000;108(1):40-7.
1999: A Deptala; Xuguang Li; Elzbieta Bedner; W Cheng; Frank Traganos; Zbigniew Darzynkiewicz
Differences in induction of p53, p21WAF1 and apoptosis in relation to cell cycle phase of MCF-7 cells treated with camptothecin.
International journal of oncology 1999;15(5):861-71.
1999: Tze-Chen Hsieh; P Burfeind; K Laud; J M Backer; Frank Traganos; Zbigniew Darzynkiewicz; Joseph Wu
Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials.
International journal of oncology 1999;15(2):245-52.
1999: Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz
Histone H3 phosphorylation in human monocytes and during HL-60 cell differentiation.
Experimental cell research 1999;246(1):212-20.
1998: Gloria Juan; Frank Traganos; W M James; JM Ray; Michel Roberge; D M Sauve; H Anderson; Zbigniew Darzynkiewicz
Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis.
Cytometry 1998;32(2):71-7.
1998: Zbigniew Darzynkiewicz; Elzbieta Bedner; Frank Traganos; T Murakami
Critical aspects in the analysis of apoptosis and necrosis.
Human cell 1998;11(1):3-12.
1998: Zbigniew Darzynkiewicz; Frank Traganos
Measurement of apoptosis.
Advances in biochemical engineering/biotechnology 1998;62():33-73.
1997: S R Haider; Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz
Immunoseparation and immunodetection of nucleic acids labeled with halogenated nucleotides.
Experimental cell research 1997;234(2):498-506.
1997: R Vibhakar; Gloria Juan; Frank Traganos; Zbigniew Darzynkiewicz; L R Finger
Activation-induced expression of human programmed death-1 gene in T-lymphocytes.
Experimental cell research 1997;232(1):25-8.
1997: H Dorota Halicka; Karen Seiter; Eric J Feldman; Frank Traganos; Abraham Mittelman; T Ahmed; Zbigniew Darzynkiewicz
Cell cycle specificity of apoptosis during treatment of leukaemias.
Apoptosis : an international journal on programmed cell death 1997;2(1):25-39.
1997: Zbigniew Darzynkiewicz; Gloria Juan; Xuguang Li; Wojciech Gorczyca; T Murakami; Frank Traganos
Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis).
Cytometry 1997;27(1):1-20.
1997: Karen Seiter; Eric J Feldman; H Dorota Halicka; Frank Traganos; Zbigniew Darzynkiewicz; DE Lake; Tauseef Ahmed
Phase I clinical and laboratory evaluation of topotecan and cytarabine in patients with acute leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(1):44-51.
1996: Frank Traganos; Karen Seiter; E Feldman; H Dorota Halicka; Zbigniew Darzynkiewicz
Induction of apoptosis by camptothecin and topotecan.
Annals of the New York Academy of Sciences 1996;803():101-10.
1996: Zbigniew Darzynkiewicz; S Bruno; G Del Bino; Frank Traganos
The cell cycle effects of camptothecin.
Annals of the New York Academy of Sciences 1996;803():93-100.
1996: Zbigniew Darzynkiewicz; J Gong; Gloria Juan; Barbara Ardelt; Frank Traganos
Cytometry of cyclin proteins.
Cytometry 1996;25(1):1-13.
1996: Gloria Juan; J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Unscheduled expression of cyclins D1 and D3 in human tumour cell lines.
Cell proliferation 1996;29(5):259-66.
1996: S Hara; H Dorota Halicka; S Bruno; J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Effect of protease inhibitors on early events of apoptosis.
Experimental cell research 1996;223(2):372-84.
1995: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Growth imbalance and altered expression of cyclins B1, A, E, and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1485-93.
1995: Karen Seiter; Eric J Feldman; Frank Traganos; Xuguang Li; H Dorota Halicka; Zbigniew Darzynkiewicz; C A Lederman; M B Romero; Tauseef Ahmed
Evaluation of in vivo induction of apoptosis in patients with acute leukemia treated on a phase I study of paclitaxel.
Leukemia 1995;9(11):1961-6.
1995: Xuguang Li; W M James; Frank Traganos; Zbigniew Darzynkiewicz
Application of biotin, digoxigenin or fluorescein conjugated deoxynucleotides to label DNA strand breaks for analysis of cell proliferation and apoptosis using flow cytometry.
Biotechnic & histochemistry : official publication of the Biological Stain Commission 1995;70(5):234-42.
1995: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Discrimination of G2 and mitotic cells by flow cytometry based on different expression of cyclins A and B1.
Experimental cell research 1995;220(1):226-31.
1995: U Bhatia; K Danishefsky; Frank Traganos; Zbigniew Darzynkiewicz
Induction of apoptosis and cell cycle-specific change in expression of p53 in normal lymphocytes and MOLT-4 leukemic cells by nitrogen mustard.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(8):873-80.
1995: U Bhatia; Frank Traganos; Zbigniew Darzynkiewicz
Induction of cell differentiation potentiates apoptosis triggered by prior exposure to DNA-damaging drugs.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(8):937-44.
1995: T Murakami; Xuguang Li; J Gong; U Bhatia; Frank Traganos; Zbigniew Darzynkiewicz
Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity.
Cancer research 1995;55(14):3093-8.
1995: Xuguang Li; Frank Traganos; Myron R Melamed; Zbigniew Darzynkiewicz
Single-step procedure for labeling DNA strand breaks with fluorescein- or BODIPY-conjugated deoxynucleotides: detection of apoptosis and bromodeoxyuridine incorporation.
Cytometry 1995;20(2):172-80.
1995: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Threshold expression of cyclin E but not D type cyclins characterizes normal and tumour cells entering S phase.
Cell proliferation 1995;28(6):337-46.
1995: J Gong; U Bhatia; Frank Traganos; Zbigniew Darzynkiewicz
Expression of cyclins A, D2 and D3 in individual normal mitogen stimulated lymphocytes and in MOLT-4 leukemic cells analyzed by multiparameter flow cytometry.
Leukemia 1995;9(5):893-9.
1994: Xuguang Li; Frank Traganos; Zbigniew Darzynkiewicz
Simultaneous analysis of DNA replication and apoptosis during treatment of HL-60 cells with camptothecin and hyperthermia and mitogen stimulation of human lymphocytes.
Cancer research 1994;54(16):4289-93.
1994: J Gong; Barbara Ardelt; Frank Traganos; Zbigniew Darzynkiewicz
Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines.
Cancer research 1994;54(16):4285-8.
1994: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Staurosporine blocks cell progression through G1 between the cyclin D and cyclin E restriction points.
Cancer research 1994;54(12):3136-9.
1994: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry.
Analytical biochemistry 1994;218(2):314-9.
1994: M A Hotz; J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes.
Cytometry 1994;15(3):237-44.
1994: Frank Traganos; J Gong; Barbara Ardelt; Zbigniew Darzynkiewicz
Effect of staurosporine on MOLT-4 cell progression through G2 and on cytokinesis.
Journal of cellular physiology 1994;158(3):535-44.
1994: X Li; J Gong; E Feldman; Karen Seiter; Frank Traganos; Zbigniew Darzynkiewicz
Apoptotic cell death during treatment of leukemias.
Leukemia & lymphoma 1994;13 Suppl 1():65-70.
1994: Zbigniew Darzynkiewicz; J Gong; Frank Traganos
Analysis of DNA content and cyclin protein expression in studies of DNA ploidy, growth fraction, lymphocyte stimulation, and the cell cycle.
Methods in cell biology 1994;41():421-35.
1994: Frank Traganos; Zbigniew Darzynkiewicz
Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations.
Methods in cell biology 1994;41():185-94.
1993: J Gong; Frank Traganos; Zbigniew Darzynkiewicz
Simultaneous analysis of cell cycle kinetics at two different DNA ploidy levels based on DNA content and cyclin B measurements.
Cancer research 1993;53(21):5096-9.
1993: Frank Traganos; J Kapuscinski; J Gong; Barbara Ardelt; R J Darzynkiewicz; Zbigniew Darzynkiewicz
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells.
Cancer research 1993;53(19):4613-8.
1993: Wojciech Gorczyca; Frank Traganos; H Jesionowska; Zbigniew Darzynkiewicz
Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells.
Experimental cell research 1993;207(1):202-5.
1993: Wojciech Gorczyca; J Gong; Barbara Ardelt; Frank Traganos; Zbigniew Darzynkiewicz
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents.
Cancer research 1993;53(13):3186-92.
1993: Zbigniew Darzynkiewicz; Wojciech Gorczyca; P Lassota; Frank Traganos
Altered sensitivity of DNA in situ to denaturation in apoptotic cells.
Annals of the New York Academy of Sciences 1993;677():334-40.
1992: Frank Traganos; Barbara Ardelt; N Halko; S Bruno; Zbigniew Darzynkiewicz
Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells.
Cancer research 1992;52(22):6200-8.
1992: M A Hotz; Frank Traganos; Zbigniew Darzynkiewicz
Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturation.
Experimental cell research 1992;201(1):184-91.
1992: M A Hotz; G Del Bino; P Lassota; Frank Traganos; Zbigniew Darzynkiewicz
Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells.
Cancer research 1992;52(6):1530-5.
1992: S Bruno; Barbara Ardelt; J S Skierski; Frank Traganos; Zbigniew Darzynkiewicz
Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes.
Cancer research 1992;52(2):470-3.
1992: Zbigniew Darzynkiewicz; S Bruno; G Del Bino; Wojciech Gorczyca; M A Hotz; P Lassota; Frank Traganos
Features of apoptotic cells measured by flow cytometry.
Cytometry 1992;13(8):795-808.
1991: Frank Traganos; J Kapuscinski; Zbigniew Darzynkiewicz
Caffeine modulates the effects of DNA-intercalating drugs in vitro: a flow cytometric and spectrophotometric analysis of caffeine interaction with novantrone, doxorubicin, ellipticine, and the doxorubicin analogue AD198.
Cancer research 1991;51(14):3682-9.
1991: Frank Traganos; B Kaminska-Eddy; Zbigniew Darzynkiewicz
Caffeine reverses the cytotoxic and cell kinetic effects of Novantrone (mitoxantrone).
Cell proliferation 1991;24(3):305-19.
1990: Frank Traganos; M Kimmel
The stathmokinetic experiment: a single-parameter and multiparameter flow cytometric analysis.
Methods in cell biology 1990;33():249-70.