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Bruce Trapnell

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Bruce C Trapnell; David E Geller; Dana G Kissner; Susanna A McColley; Matthew McKevitt; A Bruce Montgomery; Lisa Moorehead; Mark W Rolfe; Jonathan M Rosen
Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection.
Francis X McCormack; Yoshikazu Inoue; Joel Moss; Lianne G Singer; Charlton B. Strange; Koh Nakata; Alan F Barker; Jeffrey T Chapman; Mark L Brantly; James M Stocks; Kevin K Brown; Joseph P Lynch; Hilary J Goldberg; Lisa R Young; Brent W Kinder; Gregory P Downey; Eugene J Sullivan; Thomas V Colby; Roy T McKay; Marsha M Cohen; Leslie Korbee; Angelo M Taveira-DaSilva; Hye-Seung Lee; Jeffrey P Krischer; Bruce C Trapnell
Efficacy and safety of sirolimus in lymphangioleiomyomatosis.
H Ishii; R Tazawa; C Kaneko; T Saraya; Y Inoue; E Hamano; Y Kogure; K Tomii; M Terada; Toshinori Takada; M Hojo; A Nishida; T Ichiwata; Bruce C Trapnell; H Goto; K Nakata
Clinical features of secondary pulmonary alveolar proteinosis: pre-mortem cases in Japan.

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2012: Bruce C Trapnell; David E Geller; Dana G Kissner; Susanna A McColley; Matthew McKevitt; A Bruce Montgomery; Lisa Moorehead; Mark W Rolfe; Jonathan M Rosen
Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection.
American journal of respiratory and critical care medicine 2012;185(2):171-8.
2011: Francis X McCormack; Yoshikazu Inoue; Joel Moss; Lianne G Singer; Charlton B. Strange; Koh Nakata; Alan F Barker; Jeffrey T Chapman; Mark L Brantly; James M Stocks; Kevin K Brown; Joseph P Lynch; Hilary J Goldberg; Lisa R Young; Brent W Kinder; Gregory P Downey; Eugene J Sullivan; Thomas V Colby; Roy T McKay; Marsha M Cohen; Leslie Korbee; Angelo M Taveira-DaSilva; Hye-Seung Lee; Jeffrey P Krischer; Bruce C Trapnell
Efficacy and safety of sirolimus in lymphangioleiomyomatosis.
The New England journal of medicine 2011;364(17):1595-606.
2011: H Ishii; R Tazawa; C Kaneko; T Saraya; Y Inoue; E Hamano; Y Kogure; K Tomii; M Terada; Toshinori Takada; M Hojo; A Nishida; T Ichiwata; Bruce C Trapnell; H Goto; K Nakata
Clinical features of secondary pulmonary alveolar proteinosis: pre-mortem cases in Japan.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;37(2):465-8.
2011: T Suzuki; B Maranda; T Sakagami; P Catellier; C-Y Couture; Brenna Carey; C Chalk; Bruce C Trapnell
Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;37(1):201-4.
2010: Takuji Suzuki; Takuro Sakagami; Lisa R Young; Brenna C Carey; Robert E Wood; Maurizio Luisetti; Susan E Wert; Bruce K Rubin; Katharine Kevill; Claudia Chalk; Jeffrey A Whitsett; Carrie Stevens; Lawrence M Nogee; Ilaria Campo; Bruce C Trapnell
Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy.
American journal of respiratory and critical care medicine 2010;182(10):1292-304.
2010: Lisa R Young; Rhonda Vandyke; Peter M Gulleman; Yoshikazu Inoue; Kevin K Brown; Laura S Schmidt; W Marston Linehan; Fuad Hajjar; Brent W Kinder; Bruce C Trapnell; John J Bissler; David Neal Franz; Francis X McCormack
Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases.
Chest 2010;138(3):674-81.
2010: Takuro Sakagami; David Beck; Kanji Uchida; Takuji Suzuki; Brenna C Carey; Koh Nakata; Gary Keller; Robert E Wood; Susan E Wert; Machiko Ikegami; Jeffrey A Whitsett; Maurizio Luisetti; Stella Davies; Jeffrey P Krischer; Alan Brody; Fred Ryckman; Bruce C Trapnell
Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates.
American journal of respiratory and critical care medicine 2010;182(1):49-61.
2010: Ryushi Tazawa; Bruce C Trapnell; Yoshikazu Inoue; Toru Arai; Toshinori Takada; Yasuyuki Nasuhara; Nobuyuki Hizawa; Yasunori Kasahara; Koichiro Tatsumi; Masayuki Hojo; Haruyuki Ishii; Masanori Yokoba; Naohiko Tanaka; Etsuro Yamaguchi; Ryosuke Eda; Yoshiko Tsuchihashi; Konosuke Morimoto; Masanori Akira; Masaki Terada; Junji Otsuka; Masahito Ebina; Chinatsu Kaneko; Toshihiro Nukiwa; Jeffrey P Krischer; Kohei Akazawa; Koh Nakata
Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis.
American journal of respiratory and critical care medicine 2010;181(12):1345-54.
2010: Brenna Carey; Bruce C Trapnell
The molecular basis of pulmonary alveolar proteinosis.
Clinical immunology (Orlando, Fla.) 2010;135(2):223-35.
2009: Bruce C Trapnell; Brenna C Carey; Kanji Uchida; Takuji Suzuki
Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages.
Current opinion in immunology 2009;21(5):514-21.
2009: Kanji Uchida; Koh Nakata; Takuji Suzuki; Maurizio Luisetti; Masato Watanabe; Diana E Koch; Carrie A Stevens; DC Beck; Lee A Denson; Brenna C Carey; Naoto Keicho; Jeffrey P Krischer; Yoshitsugu Yamada; Bruce C Trapnell
Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects.
Blood 2009;113(11):2547-56.
2008: Takuji Suzuki; Takuro Sakagami; Bruce K Rubin; Lawrence M Nogee; Robert E Wood; Sarah L Zimmerman; Teresa Smolarek; Megan K Dishop; Susan E Wert; Jeffrey A Whitsett; Gregory Grabowski; Brenna C Carey; Carrie Stevens; Johannes C M van der Loo; Bruce C Trapnell
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.
The Journal of experimental medicine 2008;205(12):2703-10.
2008: Robert A Sandhaus; Gerard Turino; James Stocks; Charlton B. Strange; Bruce C Trapnell; Edwin K Silverman; Sarah E Everett; James K Stoller
alpha1-Antitrypsin augmentation therapy for PI*MZ heterozygotes: a cautionary note.
Chest 2008;134(4):831-4.
2008: Yoshikazu Inoue; Bruce C Trapnell; Ryushi Tazawa; Toru Arai; Toshinori Takada; Nobuyuki Hizawa; Yasunori Kasahara; Koichiro Tatsumi; Masaaki Hojo; Toshio Ichiwata; Naohiko Tanaka; Etsuro Yamaguchi; Ryosuke Eda; Kazunori Oishi; Yoshiko Tsuchihashi; Chinatsu Kaneko; Toshihiro Nukiwa; Mitsunori Sakatani; Jeffrey P Krischer; Koh Nakata
Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan.
American journal of respiratory and critical care medicine 2008;177(7):752-62.
2007: Gail H Deutsch; Lisa R Young; Robin Deterding; Leland L Fan; Sharon Dell; Judy A Bean; Alan S Brody; Lawrence M Nogee; Bruce C Trapnell; Claire Langston; Eric A Albright; Frederic B Askin; Peter Baker; Pauline M Chou; Carlyne M Cool; Susan C Coventry; Ernest Cutz; Mary M Davis; Megan K Dishop; Csaba Galambos; Kathleen Patterson; William D Travis; Susan E Wert; Frances V White
Diffuse lung disease in young children: application of a novel classification scheme.
American journal of respiratory and critical care medicine 2007;176(11):1120-8.
2007: Masato Watanabe; Kanji Uchida; Kazuhide Nakagaki; Hiroko Kanazawa; Bruce C Trapnell; Yoshihiko Hoshino; Hiroshi Kagamu; Hirohisa Yoshizawa; Naoto Keicho; Hajime Goto; Koh Nakata
Anti-cytokine autoantibodies are ubiquitous in healthy individuals.
FEBS letters 2007;581(10):2017-21.
2007: David H Perlmutter; Jeffrey L Brodsky; William F Balistreri; Bruce C Trapnell
Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review.
Hepatology (Baltimore, Md.) 2007;45(5):1313-23.
2007: Brenna Carey; Margaret K Staudt; Dana Bonaminio; Johannes C M van der Loo; Bruce C Trapnell
PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2440-7.
2007: Kanji Uchida; David C Beck; Takashi Yamamoto; Pierre-Yves Berclaz; Shuichi Abe; Margaret K Staudt; Brenna Carey; Marie-Dominique Filippi; Susan E Wert; Lee A Denson; Jonathan T Puchalski; Diane M Hauck; Bruce C Trapnell
GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis.
The New England journal of medicine 2007;356(6):567-79.
2007: Pierre-Yves Berclaz; Brenna Carey; Marie-Dominique Fillipi; Kara Wernke-Dollries; Nick Geraci; Stephanie Cush; Terry Richardson; Joseph A Kitzmiller; Michael O'Connor; Christina Hermoyian; Thomas R Korfhagen; Jeffrey A Whitsett; Bruce C Trapnell
GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.
American journal of respiratory cell and molecular biology 2007;36(1):114-21.
2005: Mercedes Gonzalez-Juarrero; Jessica M Hattle; Angelo Izzo; Ana Paula Junqueira-Kipnis; Tae S Shim; Bruce C Trapnell; Andrea M Cooper; Ian M Orme
Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection.
Journal of leukocyte biology 2005;77(6):914-22.
2004: Jeffrey A Whitsett; Susan E Wert; Bruce C Trapnell
Genetic disorders influencing lung formation and function at birth.
Human molecular genetics 2004;13 Spec No 2():R207-15.
2004: Kanji Uchida; Koh Nakata; Bruce C Trapnell; Takahiro Terakawa; Emi Hamano; Ayako Mikami; Ikumi Matsushita; John F Seymour; Masayoshi Oh-Eda; Ikuo Ishige; Yoshinobu Eishi; Takayuki Kitamura; Yoshitsugu Yamada; Kazuo Hanaoka; Naoto Keicho
High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis.
Blood 2004;103(3):1089-98.
2003: Bruce C Trapnell; Jeffrey A Whitsett; Koh Nakata
Pulmonary alveolar proteinosis.
The New England journal of medicine 2003;349(26):2527-39.
2003: Tracey L Bonfield; Baisakhi Raychaudhuri; Anagha Malur; Susamma Abraham; Bruce C Trapnell; mani kavuru; Mary Jane Thomassen
PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor.
American journal of physiology. Lung cellular and molecular physiology 2003;285(5):L1132-6.
2002: Pierre-Yves Berclaz; Zsuzsanna Zsengellér; Yoko Shibata; Kazuhisa Otake; Steven Strasbaugh; Jeffrey A Whitsett; Bruce C Trapnell
Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6332-42.
2002: Pierre-Yves Berclaz; Yoko Shibata; Jeffrey A Whitsett; Bruce C Trapnell
GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lung.
Blood 2002;100(12):4193-200.
2002: Bruce C Trapnell
Granulocyte macrophage-colony stimulating factor augmentation therapy in sepsis: is there a role?
American journal of respiratory and critical care medicine 2002;166(2):129-30.
2002: Bruce C Trapnell; Jeffrey A Whitsett
Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense.
Annual review of physiology 2002;64():775-802.
2001: Yoko Shibata; Zsuzsanna Zsengeller; Kazuhisa Otake; N Palaniyar; Bruce C Trapnell
Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema.
Blood 2001;98(9):2845-52.
2001: Yoko Shibata; Pierre-Yves Berclaz; ZC Chroneos; Mitsuhiro Yoshida; Jeffrey A Whitsett; Bruce C Trapnell
GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1.
Immunity 2001;15(4):557-67.
2001: Juliana J Conkright; James P Bridges; Cheng-Lun Na; W F Voorhout; Bruce C Trapnell; Stephan W Glasser; Timothy E Weaver
Secretion of surfactant protein C, an integral membrane protein, requires the N-terminal propeptide.
The Journal of biological chemistry 2001;276(18):14658-64.
2001: Zsuzsanna Zsengellér; Gary F Ross; Bruce C Trapnell; Csaba Szabó; Jeffrey A Whitsett
Adenovirus infection increases iNOS and peroxynitrite production in the lung.
American journal of physiology. Lung cellular and molecular physiology 2001;280(3):L503-11.
2000: Zsuzsanna Zsengellér; Kazuhisa Otake; S A Hossain; Pierre-Yves Berclaz; Bruce C Trapnell
Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection.
Journal of virology 2000;74(20):9655-67.
1999: KS Harrod; Bruce C Trapnell; Kazuhisa Otake; Thomas R Korfhagen; Jeffrey A Whitsett
SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection.
The American journal of physiology 1999;277(3 Pt 1):L580-8.
1999: HS Iwamoto; Bruce C Trapnell; CJ McConnell; C Daugherty; Jeffrey A Whitsett
Pulmonary inflammation associated with repeated, prenatal exposure to an E1, E3-deleted adenoviral vector in sheep.
Gene therapy 1999;6(1):98-106.
1998: K Otake; D L Ennist; KS Harrod; Bruce C Trapnell
Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses.
Human gene therapy 1998;9(15):2207-22.
1998: KS Harrod; TW Hermiston; Bruce C Trapnell; William S M Wold; Jeffrey A Whitsett
Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression.
Human gene therapy 1998;9(13):1885-98.
1997: Zsuzsanna Zsengellér; Susan E Wert; Cindy J Bachurski; K L Kirwin; Bruce C Trapnell; Jeffrey A Whitsett
Recombinant adenoviral vector disrupts surfactant homeostasis in mouse lung.
Human gene therapy 1997;8(11):1331-44.
1997: Zsuzsanna Zsengellér; G P Boivin; S S Sawchuk; Bruce C Trapnell; Jeffrey A Whitsett; Raphael Hirsch
Anti-T cell receptor antibody prolongs transgene expression and reduces lung inflammation after adenovirus-mediated gene transfer.
Human gene therapy 1997;8(8):935-41.
1996: N Mittereder; Keith March; Bruce C Trapnell
Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy.
Journal of virology 1996;70(11):7498-509.
1996: James M Stark; R S Amin; Bruce C Trapnell
Infection of A549 cells with a recombinant adenovirus vector induces ICAM-1 expression and increased CD-18-dependent adhesion of activated neutrophils.
Human gene therapy 1996;7(14):1669-81.
1996: M I Gorziglia; M J Kadan; S Yei; J Lim; G M Lee; R Luthra; Bruce C Trapnell
Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy.
Journal of virology 1996;70(6):4173-8.
1996: A H Jobe; M Ikegami; S Yei; J A Whitsett; Bruce C Trapnell
Surfactant effects on aerosolized and instilled adenoviral-mediated gene transfer.
Human gene therapy 1996;7(6):697-704.
1996: S J Sawchuk; Gregory P Boivin; L E Duwel; W Ball; K Bove; Bruce C Trapnell; Raphael Hirsch
Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium.
Human gene therapy 1996;7(4):499-506.
1996: Robert W Wilmott; R S Amin; C R Perez; Susan E Wert; G Keller; Gregory P Boivin; Raphael Hirsch; J De Inocencio; P Lu; S F Reising; S Yei; Jeffrey A Whitsett; Bruce C Trapnell
Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates.
Human gene therapy 1996;7(3):301-18.
1995: A Holzinger; Bruce C Trapnell; Timothy E Weaver; Jeffrey A Whitsett; H S Iwamoto
Intraamniotic administration of an adenoviral vector for gene transfer to fetal sheep and mouse tissues.
Pediatric research 1995;38(6):844-50.
1995: M C Vincent; Bruce C Trapnell; R P Baughman; Susan E Wert; Jeffrey A Whitsett; H S Iwamoto
Adenovirus-mediated gene transfer to the respiratory tract of fetal sheep in utero.
Human gene therapy 1995;6(8):1019-28.
1995: Gary L Clayman; Bruce C Trapnell; N Mittereder; Ta-Jen Liu; Susan A Eicher; S Zhang; Edward J Shillitoe
Transduction of normal and malignant oral epithelium by an adenovirus vector: the effect of dose and treatment time on transduction efficiency and tissue penetration.
Cancer gene therapy 1995;2(2):105-11.
1995: Zsuzsanna Zsengeller; Susan E Wert; William M Hull; X Hu; S Yei; Bruce C Trapnell; Jeffrey A Whitsett
Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice.
Human gene therapy 1995;6(4):457-67.
1995: R Amin; Robert W Wilmott; Y Schwarz; Bruce C Trapnell; J Stark
Replication-deficient adenovirus induces expression of interleukin-8 by airway epithelial cells in vitro.
Human gene therapy 1995;6(2):145-53.
1995: Keith March; J E Madison; Bruce C Trapnell
Pharmacokinetics of adenoviral vector-mediated gene delivery to vascular smooth muscle cells: modulation by poloxamer 407 and implications for cardiovascular gene therapy.
Human gene therapy 1995;6(1):41-53.
1994: S Yei; Cindy J Bachurski; Timothy E Weaver; Susan E Wert; Bruce C Trapnell; Jeffrey A Whitsett
Adenoviral-mediated gene transfer of human surfactant protein B to respiratory epithelial cells.
American journal of respiratory cell and molecular biology 1994;11(3):329-36.
1994: S Yei; N Mittereder; Susan E Wert; Jeffrey A Whitsett; Robert W Wilmott; Bruce C Trapnell
In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung.
Human gene therapy 1994;5(6):731-44.
1994: N Mittereder; S Yei; Cindy J Bachurski; J Cuppoletti; Jeffrey A Whitsett; P Tolstoshev; Bruce C Trapnell
Evaluation of the efficacy and safety of in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA.
Human gene therapy 1994;5(6):717-29.
1994: S Yei; N Mittereder; K Tang; C O'Sullivan; Bruce C Trapnell
Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung.
Gene therapy 1994;1(3):192-200.
1993: T A Smith; M G Mehaffey; Dawn B Kayda; J M Saunders; S Yei; Bruce C Trapnell; A McClelland; Michael Kaleko
Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice.
Nature genetics 1993;5(4):397-402.
1982: Raymond Dalgleish; Bruce C Trapnell; R G Crystal; P Tolstoshev
Copy number of a human type I alpha 2 collagen gene.
The Journal of biological chemistry 1982;257(22):13816-22.
1981: P Tolstoshev; R Haber; Bruce C Trapnell; R G Crystal
Procollagen messenger RNA levels and activity and collagen synthesis during the fetal development of sheep lung, tendon, and skin.
The Journal of biological chemistry 1981;256(18):9672-9.
1981: P Tolstoshev; R A Berg; S I Rennard; K H Bradley; Bruce C Trapnell; R G Crystal
Procollagen production and procollagen messenger RNA levels and activity in human lung fibroblasts during periods of rapid and stationary growth.
The Journal of biological chemistry 1981;256(6):3135-40.
1980: C D Boyd; P Tolstoshev; M P Schafer; Bruce C Trapnell; H C Coon; P J Kretschmer; A W Nienhuis; R G Crystal
Isolation and characterization of a 15-kilobase genomic sequence coding for part of the Pro alpha 2 chain of sheep type I collagen.
The Journal of biological chemistry 1980;255(7):3212-20.