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Christian Trautwein

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Alexander Wehr; Henning W Zimmermann; Christian Trautwein; Christer Baeck; Nikolaus Gassler; Linda Hammerich; Felix Heymann; Kanishka Hittatiya; Andreas Ludwig; Tom Luedde; Christian Martin; Patricia Maria Niemietz; Oliver Pack; Frank Tacke
Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis.
Christoph Grouls; Maximillian Hatting; Fabian Kiessling; Christiane K Kuhl; Wiltrud Lederle; Sibylle Pochon; Anne Rix; Isabelle Tardy; Christian Trautwein; Moritz Palmowski
Liver Dysplasia: US Molecular Imaging with Targeted Contrast Agent Enables Early Assessment.
U Herbers; Tom Luedde; A Mueller; Samad Amini-Bavil-Olyaee; Christian Trautwein; Frank Tacke
Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains.

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2013: Alexander Wehr; Henning W Zimmermann; Christian Trautwein; Christer Baeck; Nikolaus Gassler; Linda Hammerich; Felix Heymann; Kanishka Hittatiya; Andreas Ludwig; Tom Luedde; Christian Martin; Patricia Maria Niemietz; Oliver Pack; Frank Tacke
Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(10):5226-36.
2013: Christoph Grouls; Maximillian Hatting; Fabian Kiessling; Christiane K Kuhl; Wiltrud Lederle; Sibylle Pochon; Anne Rix; Isabelle Tardy; Christian Trautwein; Moritz Palmowski
Liver Dysplasia: US Molecular Imaging with Targeted Contrast Agent Enables Early Assessment.
Radiology 2013;267(2):487-95.
2013: U Herbers; Tom Luedde; A Mueller; Samad Amini-Bavil-Olyaee; Christian Trautwein; Frank Tacke
Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains.
Journal of viral hepatitis 2013;20(2):141-8.
2013: Junfeng An; Matthias Endres; Christoph Harms; Gisela Lättig-Tünnemann; Sabrina L L Lee; Mingyi Li; Ana D Mandić; Felix Mehrhof; Gernot Sellge; Christian Trautwein; Stefan Donath
ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis.
Journal of hepatology 2013;58(2):297-305.
2013: Hacer Sahin; Petra Schmitz; Konrad L Streetz; Christian Trautwein; Marie-Luise Berres; Erawan Borkham-Kamphorst; Nicole T do O; Michaela Kaldenbach; Christian Liedtke; Kathrin Maedler; Ralf Weiskirchen; Hermann E Wasmuth
Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes.
Hepatology (Baltimore, Md.) 2013;57(2):797-805.
2013: Miriam K Stock; Frank Tacke; Christian Trautwein; Hermann E Wasmuth; Muhammad Alsamman; Marie-Luise Berres; Nicole T do O; Linda Hammerich; Daniel Heinrichs; Andreas Nellen; Hacer Sahin
Met-CCL5 modifies monocyte subpopulations during liver fibrosis regression.
International journal of clinical and experimental pathology 2013;6(4):678-85.
2013: Paul Manka; Andreas Paul; Fuat H Saner; Martin Schlattjan; Jan-Peter Sowa; Frank Tacke; Christian Trautwein; Lars P Bechmann; Guido Gerken; Christoph Jochum; Julia Kälsch; Ali Canbay
Serum sodium based modification of the MELD does not improve prediction of outcome in acute liver failure.
BMC gastroenterology 2013;13():58.
2013: Steffen K Meurer; Hacer Sahin; Muhammad Alsamman; David A Brenner; Tatiana Kisseleva; Christian Trautwein; Hermann E Wasmuth; Ralf Weiskirchen; David Scholten
Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line.
PloS one 2013;8(2):e56116.
2013: Christoph Roderburg; David Scholten; Frank Tacke; Christian Trautwein; David Vargas Cardenas; Mihael Vucur; Norbert Frey; Alexander Koch; Mark Luedde; Tom Luedde
Circulating microRNA-150 serum levels predict survival in patients with critical illness and sepsis.
PloS one 2013;8(1):e54612.
2013: Dennis Eurich; Anja Kiessling; Peter Neuhaus; Ruth Neuhaus; Ulf P Neumann; Gero Puhl; Christian Trautwein; Hermann Wasmuth; Ali Yahyazadeh; Sabine Boas-Knoop; Marcus Bahra
YKL-40-gene polymorphism affects acute cellular rejection and fibrosis progression after transplantation for hepatitis C virus-induced liver disease.
Journal of gastroenterology and hepatology 2013;28(1):153-60.
2012: Yann Malato; Malika Al-Masaoudi; Naiara Beraza; Jörn Bornemann; Francisco Javier Cubero; Haksier Ehedego; Nikolaus Gassler; Christian Liedtke; Christian Trautwein
NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice.
Gastroenterology 2012;143(6):1597-1608.e11.
2012: Carlo Schneider; Frank Staib; Nikolaus Gassler; Anja Hohmeyer; Sebastian Huss; Sergio A Lira; Tom Luedde; Andreas Teufel; Christian Trautwein; Mihael Vucur; Gudrun Walenda; Hermann E Wasmuth; Tetyana Yevsa; Lars Zender; Henning W Zimmermann; Frank Tacke
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer.
Gut 2012;61(12):1733-43.
2012: Matthias Bartneck; Jörg Bornemann; Josef Ehling; Nikolaus Gassler; Uwe Gbureck; Jürgen Groll; Felix Heymann; Heidrun A Keul; Twan Lammers; Tom Lüdde; Thomas Ritz; Christian Trautwein; Mona Wambach; Frank Tacke
Peptide-functionalized gold nanorods increase liver injury in hepatitis.
ACS nano 2012;6(10):8767-77.
2012: H H Lutz; Konrad L Streetz; Frank Tacke; A Koch; T Luedde; Christian Trautwein; Hermann E Wasmuth; J J W Tischendorf
Endoscopic ultrasound as an early diagnostic tool for primary sclerosing cholangitis: a prospective pilot study.
Endoscopy 2012;44(10):934-9.
2012: Yulia A Nevzorova; Piotr Sicinski; Frank Tacke; Christian Trautwein; Ralf Weiskirchen; Jörg-Martin Bangen; Nikolaus Gassler; Ute Haas; Wei Hu; Sebastian Huss; Christian Liedtke
Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice.
Hepatology (Baltimore, Md.) 2012;56(3):1140-9.
2012: Hacer Sahin; Christian Trautwein; Hermann E Wasmuth
TLR4 stresses the liver.
Gut 2012;61(9):1241-2.
2012: Christoph Grouls; Max Hatting; Fabian Kiessling; Christiane Kuhl; Georg Mühlenbruch; Florian F Behrendt; Jessica Bzyl; Tobias Penzkofer; Isabelle Tardy; Christian Trautwein; Moritz Palmowski
Development and validation of an intrinsic landmark-based gating protocol applicable for functional and molecular ultrasound imaging.
European radiology 2012;22(8):1789-96.
2012: Junfeng An; Matthias Endres; Christoph Harms; Arnd Heuser; Gisela Lättig-Tünnemann; Yann Malato; Ana D Mandić; Gernot Sellge; Christian Trautwein; Stefan Donath
TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure.
Hepatology (Baltimore, Md.) 2012;56(2):715-26.
2012: Michaela Kaldenbach; Christian Trautwein; Darjus F Tschaharganeh; Hermann E Wasmuth; Laurent Dolle; Stephanie Erschfeld; Juergen Floege; Arne Giebeler; Konrad L Streetz
Hepatocyte growth factor/c-Met signalling is important for the selection of transplanted hepatocytes.
Gut 2012;61(8):1209-18.
2012: Johannes Hadem; Wolf P Hofmann; Julia Langgartner; Michael P Manns; Pavel Strnad; Frank Tacke; Christian Trautwein; Andreas Umgelter; Tony Bruns; Ali Canbay; Gerald U Denk; Panagiotis Fikatas; Guido Gerken; Frank Grünhage
Etiologies and outcomes of acute liver failure in Germany.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2012;10(6):664-9.e2.
2012: Christian Liedtke; Christian Trautwein
The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer.
European journal of cell biology 2012;91(6-7):582-9.
2012: Alexander Krüttgen; Tom Luedde; Gerhard Haase; Hans-Peter Horz; Christian Trautwein; Mihael Vucur; Josefine Weber-Heynemann; Christoph Roderburg
Study on the association of Helicobacter species with viral hepatitis-induced hepatocellular carcinoma.
Gut microbes 2012;3(3):228-33.
2012: Claudia van Roeyen; Ralf Weiskirchen; Peter Boor; Erawan Borkham-Kamphorst; Stefan Fleckenstein; Ana Kaitovic; Uta Kunter; Ina V Martin; Tammo Ostendorf; Bernard Perbal; Song Rong; Christian Trautwein; Jürgen Floege
A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects.
The American journal of pathology 2012;180(5):1979-90.
2012: Mirko Moreno Zaldivar; Marie-Luise Berres; Nikolaus Gassler; Daniel Heinrichs; Andreas Nellen; Hacer Sahin; Petra Schmitz; Konrad L Streetz; Christian Trautwein; Hermann E Wasmuth
The chemokine receptor CXCR3 limits injury after acute toxic liver damage.
Laboratory investigation; a journal of technical methods and pathology 2012;92(5):724-34.
2012: Hacer Sahin; Petra Schmitz; David Scholten; Christian Trautwein; Ralf Weiskirchen; Mirko Moreno Zaldivar; Muhammad Al-samman; Marie-Luise Berres; Erawan Borkham-Kamphorst; Dennis Doleschel; Christoph Grouls; Daniel Heinrichs; Fabian Kiessling; Christoph Kuppe; Marcus J Moeller; Andreas Nellen; Hermann E Wasmuth
Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice.
Hepatology (Baltimore, Md.) 2012;55(5):1610-9.
2012: Alexander Koch; Carlo Schneider; Christian Trautwein; Eray Yagmur; Henning W Zimmermann; Christer Baeck; Frank Tacke
Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis.
Clinical biochemistry 2012;45(6):429-35.
2012: Nicole T do O; Dennis Eurich; Christoph Heidenhain; Peter Neuhaus; Ulf P Neumann; Maximilian Schmeding; Petra Schmitz; Christian Trautwein; Marcus Bahra; Hermann E Wasmuth
A 7-gene signature of the recipient predicts the progression of fibrosis after liver transplantation for hepatitis C virus infection.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2012;18(3):298-304.
2012: Henning W Zimmermann; Christian Trautwein; Alexander Koch; Sebastian Seidler; Frank Tacke
Circulating soluble urokinase plasminogen activator is elevated in patients with chronic liver disease, discriminates stage and aetiology of cirrhosis and predicts prognosis.
Liver international : official journal of the International Association for the Study of the Liver 2012;32(3):500-9.
2012: Christer Baeck; Dirk Eulberg; Nikolaus Gassler; Felix Heymann; Sebastian Huss; Karlin Raja Karlmark; Sven Klussmann; Tom Luedde; Christian Trautwein; Mihael Vucur; Alexander Wehr; Frank Tacke
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.
Gut 2012;61(3):416-26.
2012: Ramin Schirin-Sokhan; Christian Trautwein; Ron Winograd; Jhenee Bubenzer; Nicole Cabral do Ó; Dorothee Guggenberger; Hartmut Hecker; Christoph Roderburg; Jens J W Tischendorf
Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound.
World journal of gastroenterology : WJG 2012;18(6):541-5.
2012: Henning W Zimmermann; Christian Trautwein; Frank Tacke
Functional role of monocytes and macrophages for the inflammatory response in acute liver injury.
Frontiers in physiology 2012;3():56.
2012: Daniela C Kroy; Sara Sackett; Leif E Sander; Stephanie Erschfeld; Oliver Galm; Nikolaus Gassler; Lisa Hebing; Christian Trautwein; Konrad L Streetz
Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation.
PloS one 2012;7(6):e39728.
2012: Andreas Nellen; Amanda E Proudfoot; Hacer Sahin; Petra Schmitz; Christian Trautwein; Marie-Luise Berres; Daniel Heinrichs; Hermann E Wasmuth
Interference with oligomerization and glycosaminoglycan binding of the chemokine CCL5 improves experimental liver injury.
PloS one 2012;7(5):e36614.
2012: Sebastian Seidler; Christian Trautwein; Ralf Weiskirchen; Henning W Zimmermann; Frank Tacke
Elevated circulating soluble interleukin-2 receptor in patients with chronic liver diseases is associated with non-classical monocytes.
BMC gastroenterology 2012;12():38.
2012: Christoph Roderburg; Frank Tacke; Christian Trautwein; David Vargas Cardenas; Mihael Vucur; Henning Zimmermann; Katharina Berger; Brenda Bongaerts; Natalia Elfimova; Claus Hellerbrand; Alexander Koch; Mark Luedde; Tobias Mollnow; Margarete Odenthal; Tom Luedde
Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis.
PloS one 2012;7(3):e32999.
2011: Christina Khouri; Sara Dutton Sackett; Bernd Denecke; Anna Dittrich; Christian Trautwein; Fred Schaper
Glucagon counteracts interleukin-6-dependent gene expression by redundant action of Epac and PKA.
Biological chemistry 2011;392(12):1123-34.
2011: Sebastian Gross; Hartmut Hecker; Holger H Lutz; Stephan Palm; Ramin Schirin-Sokhan; Til Aach; Alexander Behrens; Christian Trautwein; Ron Winograd; J J W Tischendorf
Computer-based classification of small colorectal polyps by using narrow-band imaging with optical magnification.
Gastrointestinal endoscopy 2011;74(6):1354-9.
2011: Christian Liedtke; Dieter Riethmacher; Konrad L Streetz; Frank Tacke; Jörg-Martin Bangen; Naiara Beraza; Francisco J Cubero; Julia Freimuth; Nikolaus Gassler; Maximilian Hatting; Karlin Raja Karlmark; Gabriele A Krombach; Daniela Lambertz; Christian Trautwein
Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury.
Gastroenterology 2011;141(6):2176-87.
2011: Samad Amini-Bavil-Olyaee; U Herbers; Tom Luedde; Christian Trautwein; Frank Tacke
Impact of hepatitis B e antigen-suppressing mutations on the replication efficiency of entecavir-resistant hepatitis B virus strains.
Journal of viral hepatitis 2011;18(11):804-14.
2011: Daniel Heinrichs; Meike Knauel; Lin Leng; Andreas Nellen; Christian Offermanns; Petra Schmitz; Christian Trautwein; Jürgen Bernhagen; Marie-Luise Berres; Richard Bucala; Christian Weber; Hermann E Wasmuth
Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(42):17444-9.
2011: Nicole T do O; Dennis Eurich; Peter Neuhaus; Ulf P Neumann; Christian Trautwein; Hermann E Wasmuth
The common I148 M variant of PNPLA3 does not predict fibrosis progression after liver transplantation for hepatitis C.
Hepatology (Baltimore, Md.) 2011;54(4):1483-4.
2011: Christoph Roderburg; Christian Trautwein; Tom Luedde
MicroRNA-199a/b-3p: a new star in the liver microcosmos.
Hepatology (Baltimore, Md.) 2011;54(2):729-31.
2011: Frank Tacke; Christian Trautwein; Marie-Luise Berres; Henning W Zimmermann; Hermann E Wasmuth
Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases.
Liver international : official journal of the International Association for the Study of the Liver 2011;31(6):840-9.
2011: Hermann E Wasmuth; Christian Trautwein
Prediction of fibrosis progression in hepatitis C infection: are genetics ready for clinical use?
Journal of hepatology 2011;55(1):3-4.
2011: Holger H Lutz; Christian Trautwein
Reviving pegylated interferon as a therapeutic agent for hepatitis D: no more room for nucleos(t)ides?
Hepatology (Baltimore, Md.) 2011;53(6):2131-3.
2011: Samad Amini-Bavil-Olyaee; M R Pourkarim; S Schaefer; F Mahboudi; Marc Van Ranst; A Adeli; Christian Trautwein; Frank Tacke
Single-step real-time PCR to quantify hepatitis B virus and distinguish genotype D from non-D genotypes.
Journal of viral hepatitis 2011;18(4):300-4.
2011: Christoph Roderburg; Nicole do O; Roland Fuchs; Jhenee Bubenzer; Michael Spannbauer; Tom Luedde; Christian Trautwein; Jens J W Tischendorf
Safe use of FOLFOX in two patients with metastatic colorectal carcinoma and severe hepatic dysfunction.
Clinical colorectal cancer 2011;10(1):E6-9.
2011: Frank Tacke; Henning W Zimmermann; Christian Trautwein; Bernd Schnabl
CXCL5 plasma levels decrease in patients with chronic liver disease.
Journal of gastroenterology and hepatology 2011;26(3):523-9.
2011: Iris Lettow; Marie-Luise Berres; Petra Schmitz; Tobias Müller; Thomas Berg; Ulf P Neumann; Christian Trautwein; Hermann E Wasmuth
A Duffy antigen receptor for chemokines (DARC) polymorphism that determines pro-fibrotic chemokine serum concentrations is not directly associated with severity of hepatitis C infection.
Human immunology 2011;72(3):273-7.
2011: Naiara Beraza; Lisa Ofner-Ziegenfuss; Haksier Ehedego; Mark Boekschoten; Stephan C Bischoff; Michael Mueller; Michael Trauner; Christian Trautwein
Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis.
Gut 2011;60(3):387-96.
2011: Christoph J Wruck; Konrad Streetz; Goran Pavic; Mario E Götz; Mersedeh Tohidnezhad; Lars-Ove Brandenburg; Deike Varoga; Oliver Eickelberg; Thomas Herdegen; Christian Trautwein; Kaimin Cha; Yuet Wai Kan; Thomas Pufe
Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter.
The Journal of biological chemistry 2011;286(6):4493-9.
2011: Marie-Luise Berres; Christian Trautwein; Maximilian Schmeding; Dennis Eurich; Frank Tacke; Marcus Bahra; Peter Neuhaus; Ulf P Neumann; Hermann E Wasmuth
Serum chemokine CXC ligand 10 (CXCL10) predicts fibrosis progression after liver transplantation for hepatitis C infection.
Hepatology (Baltimore, Md.) 2011;53(2):596-603.
2011: Alexander Koch; Edouard Sanson; Christian Trautwein; Sebastian Voigt; Eray Yagmur; Jan Bruensing; Lukas Buendgens; Hanna Dückers; Andreas Horn; Frank Tacke
Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU.
Critical care (London, England) 2011;15(6):R266.
2011: Henning W Zimmermann; Christian Trautwein; Nikolaus Gassler; Tom Luedde; Jacob Nattermann; Sebastian Seidler; Frank Tacke
Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis.
PloS one 2011;6(6):e21381.
2011: Alexander Koch; Carsten Kruschinski; Edouard Sanson; Christian Trautwein; Sebastian Voigt; Eray Yagmur; Henning Zimmermann; Hanna Dückers; Andreas Horn; Frank Tacke
Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients.
Critical care (London, England) 2011;15(1):R63.
2011: Alexander Koch; Edouard Sanson; Hanna Dückers; Andreas Horn; Christian Trautwein; Sebastian Voigt; Henning W Zimmermann; Frank Tacke
Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients.
Critical care (London, England) 2011;15(1):R45.
2011: Ramin Schirin-Sokhan; Ron Winograd; Stefanie Tischendorf; Hermann E Wasmuth; Konrad Streetz; Frank Tacke; Christian Trautwein; Jens J W Tischendorf
Assessment of inflammatory and fibrotic stenoses in patients with Crohn's disease using contrast-enhanced ultrasound and computerized algorithm: a pilot study.
Digestion 2011;83(4):263-8.
2011: Frank Tacke; Christian Trautwein
Controlling autophagy: a new concept for clearing liver disease.
Hepatology (Baltimore, Md.) 2011;53(1):356-8.
2011: Christoph Roderburg; Gerd-Willem Urban; Kira Bettermann; Mihael Vucur; Henning Zimmermann; Sabine Schmidt; Jörn Janssen; Christiane Koppe; Percy Knolle; Mirco Castoldi; Frank Tacke; Christian Trautwein; Tom Luedde
Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis.
Hepatology (Baltimore, Md.) 2011;53(1):209-18.
2010: Hacer Sahin; Christian Trautwein; Hermann E Wasmuth
Functional role of chemokines in liver disease models.
Nature reviews. Gastroenterology & hepatology 2010;7(12):682-90.
2010: Karlin Raja Karlmark; Henning W Zimmermann; Christoph Roderburg; Nikolaus Gassler; Hermann E Wasmuth; Tom Luedde; Christian Trautwein; Frank Tacke
The fractalkine receptor CX₃CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes.
Hepatology (Baltimore, Md.) 2010;52(5):1769-82.
2010: Mihael Vucur; Christoph Roderburg; Kira Bettermann; Frank Tacke; Mathias Heikenwalder; Christian Trautwein; Tom Luedde
Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?
Oncotarget 2010;1(5):373-8.
2010: E Sanson; N Gassler; Christian Trautwein; Hermann E Wasmuth
Cavitating mesenteric lymph node syndrome: a rare complication of refractory celiac disease.
Zeitschrift für Gastroenterologie 2010;48(9):1133-7.
2010: Hermann E Wasmuth; Frank Tacke; Christian Trautwein
Chemokines in liver inflammation and fibrosis.
Seminars in liver disease 2010;30(3):215-25.
2010: Leif E Sander; Sara Dutton Sackett; Uta Dierssen; Naiara Beraza; Reinhold P Linke; Michael Müller; J Magarian Blander; Frank Tacke; Christian Trautwein
Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function.
The Journal of experimental medicine 2010;207(7):1453-64.
2010: Christoph Roderburg; Jhenee Bubenzer; Michael Spannbauer; Nicole do O; Andreas Mahnken; Tom Ludde; Christian Trautwein; Jens J Tischendorf
Long-term survival of a HCC-patient with severe liver dysfunction treated with sorafenib.
World journal of hepatology 2010;2(6):239-42.
2010: Kira Bettermann; Mihael Vucur; Johannes Haybaeck; Christiane Koppe; Jörn Janssen; Felix Heymann; Achim Weber; Ralf Weiskirchen; Christian Liedtke; Nikolaus Gassler; Michael Müller; Rita de Vos; Monika Julia Wolf; Yannick Boege; Gitta Maria Seleznik; Nicolas Zeller; Daniel Erny; Thomas Fuchs; Stefan Zoller; Stefano Cairo; Marie-Annick Buendia; Marco Prinz; Shizuo Akira; Frank Tacke; Mathias Heikenwalder; Christian Trautwein; Tom Luedde
TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.
Cancer cell 2010;17(5):481-96.
2010: Christoph Roderburg; Christian Trautwein
Obesity and liver cancer: a key role for interleukin-6 and signal transducer and activator of transcription 3?
Hepatology (Baltimore, Md.) 2010;51(5):1850-2.
2010: Werner Plum; Darjus F Tschaharganeh; Daniela C Kroy; Eva Corsten; Stephanie Erschfeld; Uta Dierssen; Hermann E Wasmuth; Christian Trautwein; Konrad L Streetz
Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis.
The American journal of pathology 2010;176(5):2236-46.
2010: Maximilian Hatting; Oliver Galm; Martin Meyer; Christian Trautwein; Jens J W Tischendorf
[Anemia and severe thrombocytopenia in celiac disease].
Medizinische Klinik (Munich, Germany : 1983) 2010;105(4):249-52.
2010: Ruth Knüchel-Clarke; H H Lutz; Jürgen Floege; N Marx; T H Brümmendorf; Christian Trautwein
[When only the pathologist may help. Limitation and possibilities of biopsies in Internal Medicine].
Der Internist 2010;51(4):463-72.
2010: Mirko Moreno Zaldivar; Katrin Pauels; Philipp von Hundelshausen; Marie-Luise Berres; Petra Schmitz; Jörg Bornemann; M Anna Kowalska; Nikolaus Gassler; Konrad L Streetz; Ralf Weiskirchen; Christian Trautwein; Christian Weber; Hermann E Wasmuth
CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis.
Hepatology (Baltimore, Md.) 2010;51(4):1345-53.
2010: J J W Tischendorf; S Gross; Ron Winograd; Hartmut Hecker; R Auer; A Behrens; Christian Trautwein; Til Aach; T Stehle
Computer-aided classification of colorectal polyps based on vascular patterns: a pilot study.
Endoscopy 2010;42(3):203-7.
2010: Daniela C Kroy; Naiara Beraza; Darjus F Tschaharganeh; Leif E Sander; Stephanie Erschfeld; Arne Giebeler; Christian Liedtke; Hermann E Wasmuth; Christian Trautwein; Konrad L Streetz
Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice.
Hepatology (Baltimore, Md.) 2010;51(2):463-73.
2010: Alexander Koch; Ralf Weiskirchen; Edouard Sanson; Henning W Zimmermann; Sebastian Voigt; Hanna Dückers; Christian Trautwein; Frank Tacke
Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation.
Critical care (London, England) 2010;14(5):R179.
2010: Alexander Koch; Ralf Weiskirchen; Henning W Zimmermann; Edouard Sanson; Christian Trautwein; Frank Tacke
Relevance of serum leptin and leptin-receptor concentrations in critically ill patients.
Mediators of inflammation 2010;2010():.
2010: Sebastian Seidler; Henning W Zimmermann; Matthias Bartneck; Christian Trautwein; Frank Tacke
Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults.
BMC immunology 2010;11():30.
2010: Henning W Zimmermann; Sebastian Seidler; Jacob Nattermann; Nikolaus Gassler; Claus Hellerbrand; Alma Zernecke; J J W Tischendorf; Tom Luedde; Ralf Weiskirchen; Christian Trautwein; Frank Tacke
Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis.
PloS one 2010;5(6):e11049.
2010: Alexander Koch; Edouard Sanson; Anita Helm; Sebastian Voigt; Christian Trautwein; Frank Tacke
Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis.
Critical care (London, England) 2010;14(3):R94.
2010: Julia Freimuth; Nikolaus Gassler; Nives Moro; Rolf W Günther; Christian Trautwein; Christian Liedtke; Gabriele A Krombach
Application of magnetic resonance imaging in transgenic and chemical mouse models of hepatocellular carcinoma.
Molecular cancer 2010;9():94.
2010: Darjus F Tschaharganeh; Michaela Kaldenbach; Stephanie Erschfeld; J J W Tischendorf; Christian Trautwein; Konrad L Streetz
Glycoprotein 130-dependent pathways in host hepatocytes are important for liver repopulation in mice.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2010;16(1):23-32.
2010: Alexander Koch; Christian Trautwein
N-acetylcysteine on its way to a broader application in patients with acute liver failure.
Hepatology (Baltimore, Md.) 2010;51(1):338-40.
2010: H E Wasmuth; Christian Trautwein
[Liver fibrosis : clinics, diagnostics and management].
Der Internist 2010;51(1):14-20.
2010: J J W Tischendorf; Ramin Schirin-Sokhan; Konrad L Streetz; Nikolaus Gassler; Hartmut Hecker; M Meyer; Frank Tacke; Hermann E Wasmuth; Christian Trautwein; Ron Winograd
Value of magnifying endoscopy in classifying colorectal polyps based on vascular pattern.
Endoscopy 2010;42(1):22-7.
2010: Samad Amini-Bavil-Olyaee; Mihael Vucur; Tom Luedde; Christian Trautwein; Frank Tacke
Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains.
Journal of virology 2010;84(2):1026-33.
2009: Marie-Luise Berres; Christian Trautwein; Mirko Moreno Zaldivar; Petra Schmitz; Katrin Pauels; Sergio A Lira; Frank Tacke; Hermann E Wasmuth
The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo.
Biological chemistry 2009;390(10):1039-45.
2009: Samad Amini-Bavil-Olyaee; Ulf Herbers; Seyed Reza Mohebbi; Farzaneh Sabahi; Mohammad Reza Zali; Tom Luedde; Christian Trautwein; Frank Tacke
Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome.
Journal of hepatology 2009;51(4):647-54.
2009: Felix Heymann; Christian Trautwein; Frank Tacke
Monocytes and macrophages as cellular targets in liver fibrosis.
Inflammation & allergy drug targets 2009;8(4):307-18.
2009: E Kovalenko; Frank Tacke; Olav Gressner; H W Zimmermann; Birgit Lahme; A Janetzko; Tonio Wiederholt; T Berg; T Müller; Christian Trautwein; Axel M Gressner; Ralf Weiskirchen
Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis.
Journal of viral hepatitis 2009;16(9):612-20.
2009: Naiara Beraza; Yann Malato; Leif E Sander; Malika Al-Masaoudi; Julia Freimuth; Dieter Riethmacher; Gregory J Gores; Tania Roskams; Christian Liedtke; Christian Trautwein
Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.
The Journal of experimental medicine 2009;206(8):1727-37.
2009: Yulia A Nevzorova; Darjus Tschaharganeh; Nikolaus Gassler; Yan Geng; Ralf Weiskirchen; Piotr Sicinski; Christian Trautwein; Christian Liedtke
Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin.
Gastroenterology 2009;137(2):691-703, 703.e1-6.
2009: Hermann E Wasmuth; Frank Lammert; Mirko Moreno Zaldivar; Ralf Weiskirchen; Claus Hellerbrand; David Scholten; Marie-Luise Berres; Henning Zimmermann; Konrad L Streetz; Frank Tacke; Sonja Hillebrandt; Petra Schmitz; Hildegard Keppeler; Thomas Berg; Edgar Dahl; Nikolaus Gassler; Scott L Friedman; Christian Trautwein
Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.
Gastroenterology 2009;137(1):309-19, 319.e1-3.
2009: Arne Giebeler; Mark V Boekschoten; Christian Klein; Malgorzata Borowiak; Carmen Birchmeier; Nikolaus Gassler; Hermann E Wasmuth; Michael Müller; Christian Trautwein; Konrad L Streetz
c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice.
Gastroenterology 2009;137(1):297-308, 308.e1-4.
2009: Edouard Sanson; Christian Trautwein
Hepatocytes clear platelets and are key regulators of disseminated intravascular coagulation during sepsis.
Journal of hepatology 2009;50(5):1060-1.
2009: Samad Amini-Bavil-Olyaee; Ulf Herbers; Julie Sheldon; Tom Luedde; Christian Trautwein; Frank Tacke
The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains.
Hepatology (Baltimore, Md.) 2009;49(4):1158-65.
2009: Marie-Luise Berres; Barbara Schnyder; Eray Yagmur; Brett Inglis; Sven Stanzel; Jens J W Tischendorf; Alexander Koch; Ron Winograd; Christian Trautwein; Hermann E Wasmuth
Longitudinal monocyte human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(4):536-43.
2009: Hermann E Wasmuth; Carmen G Tag; Eddie Van de Leur; Claus Hellerbrand; Tobias Mueller; Thomas Berg; Gero Puhl; Peter Neuhaus; Didier Samuel; Christian Trautwein; Sandip M Kanse; Ralf Weiskirchen
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB.
Hepatology (Baltimore, Md.) 2009;49(3):775-80.
2009: Marie-Luise Berres; Sven Papen; Katrin Pauels; Petra Schmitz; Mirko Moreno Zaldivar; Claus Hellerbrand; Tobias Mueller; Thomas Berg; Ralf Weiskirchen; Christian Trautwein; Hermann E Wasmuth
A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection.
Journal of hepatology 2009;50(2):370-6.
2009: Frank Tacke; Tom Luedde; Christian Trautwein
Inflammatory pathways in liver homeostasis and liver injury.
Clinical reviews in allergy & immunology 2009;36(1):4-12.
2009: Alexander Koch; Olav Gressner; Edouard Sanson; Frank Tacke; Christian Trautwein
Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients.
Critical care (London, England) 2009;13(3):R95.
2008: Hermann E Wasmuth; Christian Trautwein
Hepatic steatosis and endocannabinoids--does it all happen within the liver?
Hepatology (Baltimore, Md.) 2008;48(6):2080-2.
2008: Cornelia Henke-Gendo; Samad Amini-Bavil-Olyaee; Deepthi Challapalli; Christian Trautwein; Heidi Deppe; Thomas F Schulz; Albert Heim; Frank Tacke
Symptomatic hepatitis B virus (HBV) reactivation despite reduced viral fitness is associated with HBV test and immune escape mutations in an HIV-coinfected patient.
The Journal of infectious diseases 2008;198(11):1620-4.
2008: Tonio Wiederholt; Michael von Westernhagen; Mirko Moreno Zaldivar; Marie-Luise Berres; Petra Schmitz; Claus Hellerbrand; Tobias Müller; Thomas Berg; Christian Trautwein; Hermann E Wasmuth
Genetic variations of the chemokine scavenger receptor D6 are associated with liver inflammation in chronic hepatitis C.
Human immunology 2008;69(12):861-6.
2008: Christian Liedtke; Christian Trautwein
A dual role of p21 in liver regeneration and hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2008;48(5):1713-4.
2008: Andrej Potthoff; Heiner Wedemeyer; Wulf O Boecher; Thomas Berg; Stefan Zeuzem; Joachim Arnold; Ulrich Spengler; Kurt Gruengreiff; Thomas Kaeser; Marcus Schuchmann; Alexandra Bergk; Nicole Forestier; Katja Deterding; Michael P Manns; Christian Trautwein
The HEP-NET B/C co-infection trial: A prospective multicenter study to investigate the efficacy of pegylated interferon-alpha2b and ribavirin in patients with HBV/HCV co-infection.
Journal of hepatology 2008;49(5):688-94.
2008: Daniel R Engel; Juliane Maurer; André P Tittel; Christina Weisheit; Taner Cavlar; Beatrix Schumak; Andreas Limmer; Nico van Rooijen; Christian Trautwein; Frank Tacke; Christian Kurts
CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5579-86.
2008: Naiara Beraza; Christian Trautwein
The gut-brain-liver axis: a new option to treat obesity and diabetes?
Hepatology (Baltimore, Md.) 2008;48(3):1011-3.
2008: J J W Tischendorf; K Wopp; K L Streetz; J Bach; M Meyer; S Tischendorf; N Gassler; A Koch; Andreas Geier; Hermann E Wasmuth; Christian Trautwein; R Winograd
[The value of duodenal biopsy within routine upper endoscopy: a prospective study in 1000 patients].
Zeitschrift für Gastroenterologie 2008;46(8):771-5.
2008: Olav Gressner; Alexander Koch; Edouard Sanson; Christian Trautwein; Frank Tacke
High C5a levels are associated with increased mortality in sepsis patients--no enhancing effect by actin-free Gc-globulin.
Clinical biochemistry 2008;41(12):974-80.
2008: Andreas Geier; Ina V Martin; Christoph G Dietrich; Natarajan Balasubramaniyan; Sonja Strauch; Frederick J Suchy; Carsten Gartung; Christian Trautwein; Meenakshisundaram Ananthanarayanan
Hepatocyte nuclear factor-4alpha is a central transactivator of the mouse Ntcp gene.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(2):G226-33.
2008: J J W Tischendorf; Andreas Geier; Christian Trautwein
Current diagnosis and management of primary sclerosing cholangitis.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2008;14(6):735-46.
2008: Yann Malato; Leif E Sander; Christian Liedtke; Malika Al-Masaoudi; Frank Tacke; Christian Trautwein; Naiara Beraza
Hepatocyte-specific inhibitor-of-kappaB-kinase deletion triggers the innate immune response and promotes earlier cell proliferation during liver regeneration.
Hepatology (Baltimore, Md.) 2008;47(6):2036-50.
2008: Frank Tacke; Christian Trautwein
Hepatitis B goes globe: Telbivudine as a new treatment option.
Hepatology (Baltimore, Md.) 2008;47(5):1786-7.
2008: Naiara Beraza; Y Malato; S Vander Borght; C Liedtke; Hermann E Wasmuth; M Dreano; R de Vos; Tania Roskams; Christian Trautwein
Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis.
Gut 2008;57(5):655-63.
2008: Uta Dierssen; Naiara Beraza; Holger H Lutz; Christian Liedtke; Matthias Ernst; Hermann E Wasmuth; Christian Trautwein
Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration.
The Journal of biological chemistry 2008;283(15):9886-95.
2008: Tom Luedde; Christian Trautwein
A molecular link between inflammation and fibrogenesis: the bacterial microflora influences hepatic fibrosis via toll-like receptor 4-dependent modification of transforming growth factor-beta signaling in hepatic stellate cells.
Hepatology (Baltimore, Md.) 2008;47(3):1089-91.
2008: Daniela Kroy; Christian Trautwein
"Peptide-based NASH therapy, a first crucial step - soon clinical reality?".
Hepatology (Baltimore, Md.) 2008;47(2):757-8.
2008: Konrad L Streetz; Regis Doyonnas; Dirk Grimm; D Denison Jenkins; Sally Fuess; Scott Perryman; Joseph Lin; Christian Trautwein; Judith A Shizuru; Helen Blau; Karl G Sylvester; Mark A Kay
Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells.
Hepatology (Baltimore, Md.) 2008;47(2):706-18.
2008: Hermann E Wasmuth; Mirko Moreno Zaldivar; Marie-Luise Berres; Alexa Werth; David Scholten; Sonja Hillebrandt; Frank Tacke; Petra Schmitz; Edgar Dahl; Tonio Wiederholt; Claus Hellerbrand; Thomas Berg; Ralf Weiskirchen; Christian Trautwein; Frank Lammert
The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection.
Journal of hepatology 2008;48(2):208-15.
2007: J J W Tischendorf; Hermann E Wasmuth; A Koch; H Hecker; Christian Trautwein; Ron Winograd
Value of magnifying chromoendoscopy and narrow band imaging (NBI) in classifying colorectal polyps: a prospective controlled study.
Endoscopy 2007;39(12):1092-6.
2007: J J W Tischendorf; Eray Yagmur; D Scholten; D Vidacek; A Koch; Ron Winograd; Axel M Gressner; Christian Trautwein; Hermann E Wasmuth; Frank Lammert
The interleukin-6 (IL6)-174 G/C promoter genotype is associated with the presence of septic shock and the ex vivo secretion of IL6.
International journal of immunogenetics 2007;34(6):413-8.
2007: Christian Liedtke; Daniela Lambertz; Nadine Schnepel; Christian Trautwein
Molecular mechanism of Mitomycin C-dependent caspase-8 regulation: implications for apoptosis and synergism with interferon-alpha signalling.
Apoptosis : an international journal on programmed cell death 2007;12(12):2259-70.
2007: Frank Tacke; Erwin Gäbele; Frauke Bataille; Robert F Schwabe; Claus Hellerbrand; Frank Klebl; Rainer H Straub; Tom Luedde; Michael P Manns; Christian Trautwein; David A Brenner; Jürgen Schölmerich; Bernd Schnabl
Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells.
Digestive diseases and sciences 2007;52(12):3404-15.
2007: Leif E Sander; Alexander Koch; Carsten Gartung; Ron Winograd; Andreas Donner; Axel Wellmann; Christian Trautwein; Andreas Geier
Lessons from a patient with an unusual hepatic overlap syndrome.
Nature clinical practice. Gastroenterology & hepatology 2007;4(11):635-40.
2007: Leif E Sander; Christian Trautwein; Christian Liedtke
Is interleukin-6 a gender-specific risk factor for liver cancer?
Hepatology (Baltimore, Md.) 2007;46(4):1304-5.
2007: Andrej Potthoff; Katja Deterding; Christian Trautwein; Kinan Rifai; Michael P Manns; Heiner Wedemeyer
Sustained HCV-RNA response and hepatitis Bs seroconversion after individualized antiviral therapy with pegylated interferon alpha plus ribavirin and active vaccination in a hepatitis C virus/hepatitis B virus-coinfected patient.
European journal of gastroenterology & hepatology 2007;19(10):906-9.
2007: Frank Tacke; Christian Trautwein
Efficient recombinant hepatitis E virus vaccine: mission accomplished?
Hepatology (Baltimore, Md.) 2007;46(3):941-3.
2007: Eray Yagmur; Mohamed Rizk; Sven Stanzel; Claus Hellerbrand; Frank Lammert; Christian Trautwein; Hermann E Wasmuth; Axel M Gressner
Elevation of endoglin (CD105) concentrations in serum of patients with liver cirrhosis and carcinoma.
European journal of gastroenterology & hepatology 2007;19(9):755-61.
2007: Christian Klein; Eva Medina; Leif Sander; Uta Dierssen; Tania Roskams; Werner Mueller; Christian Trautwein; Oliver Goldmann
Contribution of interleukin-6/gp 130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes.
The Journal of infectious diseases 2007;196(5):755-62.
2007: Christoph G Dietrich; Ina V Martin; Anne C Porn; Sebastian Voigt; Carsten Gartung; Christian Trautwein; Andreas Geier
Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(3):G585-90.
2007: Maren Luchtefeld; Heribert Schunkert; Monika Stoll; Tina Selle; Rachel Lorier; Karsten Grote; Christian Sagebiel; Jagavelu Kumaravelu; Uwe J F Tietge; Ulrike Assmus; Konrad L Streetz; Christian Hengstenberg; Marcus Fischer; Björn Mayer; Karen Maresso; Nour Eddine El Mokhtari; Stefan Schreiber; Werner Muller; Udo Bavendiek; Christina Grothusen; Helmut Drexler; Christian Trautwein; Ulrich Broeckel; Bernhard Schieffer
Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man.
The Journal of experimental medicine 2007;204(8):1935-44.
2007: Frank Tacke; Christian Trautwein; Eray Yagmur; Claus Hellerbrand; Reiner Wiest; David A Brenner; Bernd Schnabl
Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course.
Journal of gastroenterology and hepatology 2007;22(8):1256-64.
2007: Naiara Beraza; Tom Lüdde; Ulrike Assmus; Tania Roskams; Sara Vander Borght; Christian Trautwein
Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.
Gastroenterology 2007;132(7):2504-17.
2007: Naiara Beraza; Christian Trautwein
Restoration of p53 function: a new therapeutic strategy to induce tumor regression?
Hepatology (Baltimore, Md.) 2007;45(6):1578-9.
2007: Eray Yagmur; Christian Trautwein; Mathie Leers; Axel M Gressner; Frank Tacke
Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation.
Clinical biochemistry 2007;40(9-10):651-5.
2007: Andreas Geier; Alexander Koch; Jens Bach; Wolfgang Schäfer; Marc Jansen; Christian Trautwein
Profuse rectal bleeding of no visible cause.
Lancet 2007;369(9573):1664.
2007: Eray Yagmur; Ralf Weiskirchen; Axel M Gressner; Christian Trautwein; Frank Tacke
Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4.
Diabetes care 2007;30(5):1168-72.
2007: Frank Tacke; Samad Amini-Bavil-Olyaee; Albert Heim; Tom Luedde; Michael P Manns; Christian Trautwein
Acute hepatitis B virus infection by genotype F despite successful vaccination in an immune-competent German patient.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2007;38(4):353-7.
2007: Frank Tacke; Kai Fiedler; Christian Trautwein
A simple clinical score predicts high risk for upper gastrointestinal hemorrhages from varices in patients with chronic liver disease.
Scandinavian journal of gastroenterology 2007;42(3):374-82.
2007: Johannes Hadem; Volker Westerkamp; Christian Trautwein; Michael Winkler; Michael P Manns; Carsten Hafer
Hepatic gas gangrene following liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007;13(3):468-9.
2007: Christian Knackstedt; Hermann E Wasmuth; A Donner; Christian Trautwein; Ron Winograd
Diagnosis of an unusual tumor in the duodenum.
Endoscopy 2007;39 Suppl 1():E94.
2007: Tom Luedde; Naiara Beraza; Vasileios Kotsikoris; Geert Van Loo; Arianna Nenci; Rita De Vos; Tania Roskams; Christian Trautwein; Manolis Pasparakis
Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma.
Cancer cell 2007;11(2):119-32.
2007: Eva Sonnenberg-Riethmacher; Torsten Wüstefeld; Michaela Miehe; Christian Trautwein; Dieter Riethmacher
Maid (GCIP) is involved in cell cycle control of hepatocytes.
Hepatology (Baltimore, Md.) 2007;45(2):404-11.
2007: Andrej Potthoff; Katja Deterding; Christian Trautwein; Peer Flemming; Christian P Strassburg; Michael P Manns; Heiner Wedemeyer; Matthias J Bahr
Steroid treatment for severe acute cryptogenic hepatitis.
Zeitschrift für Gastroenterologie 2007;45(1):15-9.
2007: Andreas Geier; Christian Trautwein
Bile acids are "homeotrophic" sensors of the functional hepatic capacity and regulate adaptive growth during liver regeneration.
Hepatology (Baltimore, Md.) 2007;45(1):251-3.
2006: Tom Luedde; Christian Trautwein
The role of oxidative stress and antioxidant treatment in liver surgery and transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2006;12(12):1733-5.
2006: Tom Luedde; Christian Trautwein
Intracellular survival pathways in the liver.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(10):1163-74.
2006: Christian Liedtke; Christian Trautwein
The role of JNK2 in toxic liver injury.
Journal of hepatology 2006;45(5):762-4.
2006: Tom Luedde; Naiara Beraza; Christian Trautwein
Evaluation of the role of nuclear factor-kappaB signaling in liver injury using genetic animal models.
Journal of gastroenterology and hepatology 2006;21 Suppl 3():S43-6.
2006: Andreas Geier; H Deppe; S Willis; Richard Holy; Christian Trautwein; Carsten Gartung
[Multidisciplinary treatment of rectal cancer].
Deutsche medizinische Wochenschrift (1946) 2006;131(36):1945-50.
2006: Eray Yagmur; B Schnyder; D Scholten; Ramin Schirin-Sokhan; A Koch; Ron Winograd; Axel M Gressner; Christian Trautwein; Hermann E Wasmuth
[Elevated concentrations of fecal calprotectin in patients with liver cirrhosis].
Deutsche medizinische Wochenschrift (1946) 2006;131(36):1930-4.
2006: Christian Trautwein
[Therapy of hepatitis B virus infection].
Praxis 2006;95(36):1389-97.
2006: Frank Tacke; Christian Trautwein
Serum hepatitis B virus DNA level as a risk predictor for liver disease complications.
Nature clinical practice. Gastroenterology & hepatology 2006;3(8):426-7.
2006: Nils-Holger Zschemisch; Christian Liedtke; Uta Dierssen; Yulia A Nevzorova; Torsten Wüstefeld; Jürgen Borlak; Michael P Manns; Christian Trautwein
Expression of a cyclin E1 isoform in mice is correlated with the quiescent cell cycle status of hepatocytes in vivo.
Hepatology (Baltimore, Md.) 2006;44(1):164-73.
2006: Denise Hilfiker-Kleiner; Andres Hilfiker; Marc Castellazzi; Kai C Wollert; Christian Trautwein; Heribert Schunkert; Helmut Drexler
JunD attenuates phenylephrine-mediated cardiomyocyte hypertrophy by negatively regulating AP-1 transcriptional activity.
Cardiovascular research 2006;71(1):108-17.
2006: J J W Tischendorf; Martin Krüger; Christian Trautwein; N Duckstein; Andrea S Schneider; Michael P Manns; Peter N Meier
Cholangioscopic characterization of dominant bile duct stenoses in patients with primary sclerosing cholangitis.
Endoscopy 2006;38(7):665-9.
2006: Kinan Rifai; P Flemming; Michael P Manns; Christian Trautwein
[Severe drug hepatitis caused by Chelidonium].
Der Internist 2006;47(7):749-51.
2006: Eray Yagmur; Christian Trautwein; Axel M Gressner; Frank Tacke
Resistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases.
The American journal of gastroenterology 2006;101(6):1244-52.
2006: Frank Tacke; Kai Fiedler; Mario von Depka; Tom Luedde; Hartmut Hecker; Michael P Manns; Arnold Ganser; Christian Trautwein
Clinical and prognostic role of plasma coagulation factor XIII activity for bleeding disorders and 6-year survival in patients with chronic liver disease.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(2):173-81.
2006: Christian Liedtke; Nadine Gröger; Michael P Manns; Christian Trautwein
Interferon-alpha enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells.
Journal of hepatology 2006;44(2):342-9.
2006: Eray Yagmur; Frank Tacke; Claudia Weiss; Birgit Lahme; Michael P Manns; Paul Kiefer; Christian Trautwein; Axel M Gressner
Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis.
Clinical biochemistry 2006;39(1):39-45.
2005: Christian Liedtke; Nils-Holger Zschemisch; Anne Cohrs; Tania Roskams; Jürgen Borlak; Michael P Manns; Christian Trautwein
Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element.
Gastroenterology 2005;129(5):1602-15.
2005: Torsten Wuestefeld; Christian Klein; Konrad L Streetz; Naiara Beraza; Jürgen Schölmerich; Lawrence J Burgart; Lars Zender; Stefan Kubicka; Edwina S Baskin-Bey; Gregory J Gores; Michael P Manns; Christian Trautwein
Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in mice.
Hepatology (Baltimore, Md.) 2005;42(5):1082-90.
2005: Bettina Mundt; Thomas Wirth; Lars Zender; Morlen Waltemathe; Christian Trautwein; Michael P Manns; Florian Kühnel; Stefan Kubicka
Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake.
Gut 2005;54(11):1590-6.
2005: Frank Tacke; Christian Liedtke; S Bocklage; Michael P Manns; Christian Trautwein
CREB/PKA sensitive signalling pathways activate and maintain expression levels of the hepatitis B virus pre-S2/S promoter.
Gut 2005;54(9):1309-17.
2005: Thomas Gebhardt; Axel Lorentz; F Detmer; Christian Trautwein; Hueseyin Bektas; Michael P Manns; Stephan C Bischoff
Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1.
Gut 2005;54(7):928-34.
2005: Frank Tacke; Torsten Wüstefeld; Rüdiger Horn; Tom Luedde; Annavarapu Srinivas Rao; Michael P Manns; Christian Trautwein; Georg Brabant
High adiponectin in chronic liver disease and cholestasis suggests biliary route of adiponectin excretion in vivo.
Journal of hepatology 2005;42(5):666-73.
2005: Tom Luedde; Ulrike Assmus; Torsten Wüstefeld; Andreas Meyer zu Vilsendorf; Tania Roskams; Marc Schmidt-Supprian; Klaus Rajewsky; David A Brenner; Michael P Manns; Manolis Pasparakis; Christian Trautwein
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
The Journal of clinical investigation 2005;115(4):849-59.
2005: Christian Klein; Torsten Wüstefeld; Ulrike Assmus; Tania Roskams; Stefan Rose-John; Michael Müller; Michael P Manns; Mattias Ernst; Christian Trautwein
The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.
The Journal of clinical investigation 2005;115(4):860-9.
2005: Tom Luedde; Frank Tacke; Michael P Manns; Christian Trautwein
p18(INK4c) expression in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2005;41(2):405; author reply 406.
2005: Lars Zender; Sebastian Hütker; Bettina Mundt; Morlen Waltemathe; Christian Klein; Christian Trautwein; Nisar P Malek; Michael Peter Manns; Florian Kühnel; Stefan Kubicka
NFkappaB-mediated upregulation of bcl-xl restrains TRAIL-mediated apoptosis in murine viral hepatitis.
Hepatology (Baltimore, Md.) 2005;41(2):280-8.
2004: Bernhard Schieffer; Tina Selle; Andres Hilfiker; Denise Hilfiker-Kleiner; Karsten Grote; Uwe J F Tietge; Christian Trautwein; Maren Luchtefeld; Christian Schmittkamp; Sylvia Heeneman; Mat J A P Daemen; Helmut Drexler
Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis.
Circulation 2004;110(22):3493-500.
2004: Frank Tacke; Michael P Manns; Christian Trautwein
Influence of mutations in the hepatitis B virus genome on virus replication and drug resistance--implications for novel antiviral strategies.
Current medicinal chemistry 2004;11(20):2667-77.
2004: Frank Tacke; Tom Luedde; Michael P Manns; Christian Trautwein
Regulation of plasma erythropoietin in chronic liver disease.
World journal of gastroenterology : WJG 2004;10(19):2922-3.
2004: Christian Trautwein
Mechanisms of hepatitis B virus graft reinfection and graft damage after liver transplantation.
Journal of hepatology 2004;41(3):362-9.
2004: J J W Tischendorf; S Crede; P Herrmann; N Bach; C Bömeke; Michael P Manns; O Schaefer; Christian Trautwein
[Encoding of diagnosis by medical documentation assistant or ward physician. Influence on the mapping of Diagnostic Related Group (DRG) performance].
Deutsche medizinische Wochenschrift (1946) 2004;129(33):1731-5.
2004: Tom Luedde; Moritz Duderstadt; Konrad L Streetz; Frank Tacke; Stefan Kubicka; Michael P Manns; Christian Trautwein
C/EBP beta isoforms LIP and LAP modulate progression of the cell cycle in the regenerating mouse liver.
Hepatology (Baltimore, Md.) 2004;40(2):356-65.
2004: Frank Tacke; Christina Gehrke; Tom Luedde; Albert Heim; Michael P Manns; Christian Trautwein
Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of Lamivudine-resistant mutants.
Journal of virology 2004;78(16):8524-35.
2004: Malgorzata Borowiak; Alistair Garratt; Torsten Wüstefeld; Michael Strehle; Christian Trautwein; Carmen Birchmeier
Met provides essential signals for liver regeneration.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10608-13.
2004: Christian Liedtke; Christian Trautwein
A protective role of Stat3 in Fas mediated apoptosis of the liver.
Journal of hepatology 2004;40(5):874-5.
2004: Frank Tacke; Patrick Schöffski; Tom Luedde; Peter N Meier; Arnold Ganser; Michael P Manns; Christian Trautwein
Analysis of factors contributing to higher erythropoietin levels in patients with chronic liver disease.
Scandinavian journal of gastroenterology 2004;39(3):259-66.
2004: Johannes Wiegand; J J W Tischendorf; Björn Nashan; Jürgen Klempnauer; Peer Flemming; P Niemann; P Rohde; Michael P Manns; Christian Trautwein; Hans L Tillmann
Severe exacerbation of chronic hepatitis B after emergence of lamivudine resistance in a cirrhotic patient: immediate switch to adefovir dipivoxil appears to be indicated.
Zeitschrift für Gastroenterologie 2004;42(1):15-8.
2004: Florian Kühnel; Lars Zender; Thomas Wirth; Bernd Schulte; Christian Trautwein; Michael Manns; Stefan Kubicka
Tumor-specific adenoviral gene therapy: transcriptional repression of gene expression by utilizing p53-signal transduction pathways.
Cancer gene therapy 2004;11(1):28-40.
2003: Konrad L Streetz; Torsten Wüstefeld; Christian Klein; Karl-Josef Kallen; François Tronche; Ullrich A K Betz; Günther Schütz; Michael P Manns; Werner Muller; Christian Trautwein
Lack of gp130 expression in hepatocytes promotes liver injury.
Gastroenterology 2003;125(2):532-43.
2003: Christian Klein; Torsten Wüstefeld; Peter C Heinrich; Konrad L Streetz; Michael P Manns; Christian Trautwein
ME3738 protects from concanavalin A-induced liver failure via an IL-6-dependent mechanism.
European journal of immunology 2003;33(8):2251-61.
2003: Christian Liedtke; Nadine Groger; Michael P Manns; Christian Trautwein
The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism.
The Journal of biological chemistry 2003;278(30):27593-604.
2003: Heike Steiling; Torsten Wüstefeld; Philippe Bugnon; Maria Brauchle; Reinhard Fässler; Daniel Teupser; Joachim Thiery; Jeffrey I Gordon; Christian Trautwein; Sabine Werner
Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration.
Oncogene 2003;22(28):4380-8.
2003: Christian Klein; C-Thomas Bock; Heiner Wedemeyer; Torsten Wüstefeld; Stephen Locarnini; Hans P Dienes; Stefan Kubicka; Michael P Manns; Christian Trautwein
Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.
Gastroenterology 2003;125(1):9-18.
2003: Konrad L Streetz; Frank Tacke; Ludger Leifeld; Torsten Wüstefeld; Andrea Graw; Christian Klein; Kenjii Kamino; Ulrich Spengler; Hans Kreipe; Stefan Kubicka; Werner Muller; Michael P Manns; Christian Trautwein
Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases.
Hepatology (Baltimore, Md.) 2003;38(1):218-29.
2003: Lars Zender; Sebastian Hutker; Christian Liedtke; Hans L Tillmann; Steffen Zender; Bettina Mundt; Morlen Waltemathe; Thomas Gosling; Peer Flemming; Nisar P Malek; Christian Trautwein; Michael Peter Manns; Florian Kuhnel; Stefan Kubicka
Caspase 8 small interfering RNA prevents acute liver failure in mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7797-802.
2003: Christian Trautwein; Frank Tacke
[Treatment of hepatitis B and C virus infection].
Deutsche medizinische Wochenschrift (1946) 2003;128 Suppl 2():S87-9.
2003: Frank Tacke; Patrick Schöffski; Christian Trautwein; Tom Luedde; Arnold Ganser; Michael P Manns; Mario von Depka
Plasma P-selectin levels are elevated in patients with chronic liver disease.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2003;14(4):319-25.
2003: C-Thomas Bock; Boris Buerke; Hans L Tillmann; Frank Tacke; Volker Kliem; Michael P Manns; Christian Trautwein
Relevance of hepatitis B core gene deletions in patients after kidney transplantation.
Gastroenterology 2003;124(7):1809-20.
2003: Tom Luedde; Maria E Rodriguez; Frank Tacke; Yue Xiong; David A Brenner; Christian Trautwein
p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver.
Hepatology (Baltimore, Md.) 2003;37(4):833-41.
2003: Frank Tacke; Georg Brabant; Elmar Kruck; Rüdiger Horn; Patrick Schöffski; Hartmut Hecker; Michael P Manns; Christian Trautwein
Ghrelin in chronic liver disease.
Journal of hepatology 2003;38(4):447-54.
2003: Torsten Wuestefeld; Christian Klein; Konrad L Streetz; Ulrich Betz; Jörg Lauber; Jan Buer; Michael P Manns; Werner Muller; Christian Trautwein
Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration.
The Journal of biological chemistry 2003;278(13):11281-8.
2003: Ludger Leifeld; Franz Ludwig Dumoulin; Ingvill Purr; Katrin Janberg; Christian Trautwein; Martin Wolff; Michael Peter Manns; Tilman Sauerbruch; Ulrich Spengler
Early up-regulation of chemokine expression in fulminant hepatic failure.
The Journal of pathology 2003;199(3):335-44.
2003: Hans L Tillmann; C-Thomas Bock; Jörg S Bleck; Jens Rosenau; Klaus H W Böker; Hannelore Barg-Hock; Thomas Becker; Christian Trautwein; Jürgen Klempnauer; Peer Flemming; Michael P Manns
Successful treatment of fibrosing cholestatic hepatitis using adefovir dipivoxil in a patient with cirrhosis and renal insufficiency.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2003;9(2):191-6.
2003: Bettina Mundt; Florian Kühnel; Lars Zender; Yasmin Paul; Hans L Tillmann; Christian Trautwein; Michael Peter Manns; Stefan Kubicka
Involvement of TRAIL and its receptors in viral hepatitis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):94-6.
2002: Tom Luedde; Christian Liedtke; Michael P Manns; Christian Trautwein
Losing balance: cytokine signaling and cell death in the context of hepatocyte injury and hepatic failure.
European cytokine network 2002;13(4):377-83.
2002: Ludger Leifeld; Silvia Cheng; Jan Ramakers; Franz Ludwig Dumoulin; Christian Trautwein; Tilman Sauerbruch; Ulrich Spengler
Imbalanced intrahepatic expression of interleukin 12, interferon gamma, and interleukin 10 in fulminant hepatitis B.
Hepatology (Baltimore, Md.) 2002;36(4 Pt 1):1001-8.
2002: Christian Liedtke; Jörg Plümpe; Stefan Kubicka; Cynthia A Bradham; Michael P Manns; David A Brenner; Christian Trautwein
Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells.
Hepatology (Baltimore, Md.) 2002;36(2):315-25.
2002: Frank Tacke; Christian Trautwein; Shourong Zhao; Michael Andreeff; Michael P Manns; Arnold Ganser; Patrick Schöffski
Quantification of hepatic thrombopoietin mRNA transcripts in patients with chronic liver diseases shows maintained gene expression in different etiologies of liver cirrhosis.
Liver 2002;22(3):205-12.
2002: Christian Trautwein
[Therapy of chronic hepatitis B infection].
Praxis 2002;91(22):970-6.
2002: Patrick Schöffski; Frank Tacke; Christian Trautwein; Michael U Martin; Martin Caselitz; Hartmut Hecker; Michael Peter Manns; Arnold Ganser
Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease.
Liver 2002;22(2):114-20.
2002: C-Thomas Bock; Hans L Tillmann; Joseph Torresi; Jürgen Klempnauer; Stephen Locarnini; Michael P Manns; Christian Trautwein
Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantation.
Gastroenterology 2002;122(2):264-73.
2002: Stefan Kubicka; Christiane Claas; Sven Staab; Florian Kühnel; Lars Zender; Christian Trautwein; Siegfried Wagner; K Lenhard Rudolph; Michael Manns
p53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer: relation to histological subtypes, Helicobacter pylori infection, and prognosis.
Digestive diseases and sciences 2002;47(1):114-21.
2002: Kai C Wollert; Beate Fiedler; Stepan Gambaryan; Albert Smolenski; Jörg Heineke; Elke Butt; Christian Trautwein; Suzanne M Lohmann; Helmut Drexler
Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes.
Hypertension 2002;39(1):87-92.
2001: Tom Luedde; Torsten Wuestefeld; Christian Trautwein
A new player in the team: SOCS-3 socks it to cytokine signaling in the regenerating liver.
Hepatology (Baltimore, Md.) 2001;34(6):1254-6.
2001: Elmar Jaeckel; Markus Cornberg; Heiner Wedemeyer; T Santantonio; J Mayer; M Zankel; G Pastore; M Dietrich; Christian Trautwein; Michael P Manns
Treatment of acute hepatitis C with interferon alfa-2b.
The New England journal of medicine 2001;345(20):1452-7.
2001: Jens Rosenau; Hans L Tillmann; Matthias J Bahr; Christian Trautwein; Klaus H W Boeker; Björn Nashan; Jürgen Klempnauer; Michael P Manns
Successful hepatitis B reinfection prophylaxis with lamivudine and hepatitis B immune globulin in patients with positive HBV-DNA at time of liver transplantation.
Transplantation proceedings 2001;33(7-8):3637-8.
2001: Frank Tacke; Patrick Schöffski; Christian Trautwein; Michael P Manns; Arnold Ganser; Mario von Depka
Tissue factor and thrombomodulin levels are correlated with stage of cirrhosis in patients with liver disease.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2001;12(7):539-45.
2001: D Benten; Adji Widjaja; Mario von Depka; Peer Flemming; Christian Trautwein; Klaus H W Böker; Arndt Vogel; Jens Rosenau; Michael P Manns
Autoimmune hepatitis associated with coagulation disorders and immunethyreopathy.
Zeitschrift für Gastroenterologie 2001;39(10):837-40.
2001: T Lüdde; Stefan Kubicka; Jörg Plümpe; Christian Liedtke; Michael P Manns; Christian Trautwein
Ras adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy.
Oncogene 2001;20(38):5264-78.
2001: Konrad L Streetz; B Fregien; Jörg Plümpe; K Körber; Stefan Kubicka; Gabriele Sass; Stephan C Bischoff; Michael P Manns; Gisa Tiegs; Christian Trautwein
Dissection of the intracellular pathways in hepatocytes suggests a role for Jun kinase and IFN regulatory factor-1 in Con A-induced liver failure.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):514-23.
2001: M Niehof; Stefan Kubicka; Lars Zender; Michael P Manns; Christian Trautwein
Autoregulation enables different pathways to control CCAAT/enhancer binding protein beta (C/EBP beta) transcription.
Journal of molecular biology 2001;309(4):855-68.
2001: Konrad L Streetz; Torsten Wüstefeld; Christian Klein; Michael P Manns; Christian Trautwein
Mediators of inflammation and acute phase response in the liver.
Cellular and molecular biology (Noisy-le-Grand, France) 2001;47(4):661-73.
2001: Jens Rosenau; Matthias J Bahr; Hans L Tillmann; Christian Trautwein; Jürgen Klempnauer; Michael P Manns
Lamivudine and low-dose hepatitis B immune globulin for prophylaxis of hepatitis B reinfection after liver transplantation possible role of mutations in the YMDD motif prior to transplantation as a risk factor for reinfection.
Journal of hepatology 2001;34(6):895-902.
2001: Christian Trautwein; Michael P Manns
[Antiviral therapy of chronic viral hepatitis].
Der Internist 2001;42(6):913-23.
2001: Hans L Tillmann; Jens Rosenau; Christian Trautwein; Klaus H W Boeker; Michael P Manns
Successful orthotopic liver transplantation.
Gastroenterology 2001;120(6):1561-2.
2001: Hans L Tillmann; DF Chen; Christian Trautwein; Volker Kliem; A Grundey; A Berning-Haag; K Böker; Stefan Kubicka; LT Pastucha; W Stangel; Michael P Manns
Low frequency of HLA-DRB1*11 in hepatitis C virus induced end stage liver disease.
Gut 2001;48(5):714-8.
2001: M Niehof; Konrad L Streetz; T Rakemann; Stephan C Bischoff; Michael P Manns; F Horn; Christian Trautwein
Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3.
The Journal of biological chemistry 2001;276(12):9016-27.
2001: C-Thomas Bock; S Schwinn; Stephen Locarnini; J Fyfe; Michael P Manns; Christian Trautwein; H Zentgraf
Structural organization of the hepatitis B virus minichromosome.
Journal of molecular biology 2001;307(1):183-96.
2001: B Wesche; Elmar Jaeckel; Christian Trautwein; Heiner Wedemeyer; A Falorni; H Frank; Alexander von zur Mühlen; Michael P Manns; Georg Brabant
Induction of autoantibodies to the adrenal cortex and pancreatic islet cells by interferon alpha therapy for chronic hepatitis C.
Gut 2001;48(3):378-83.
2001: D Wolf; Rupert Hallmann; Gabriele Sass; Michael Sixt; Sabine Küsters; B Fregien; Christian Trautwein; Gisa Tiegs
TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1300-7.
2001: Christian Trautwein; Michael P Manns; Klaus H W Böker
[Therapy of acute liver failure].
Kongressband / Deutsche Gesellschaft für Chirurgie. Deutsche Gesellschaft für Chirurgie. Kongress 2001;118():238-47.
2000: MK Tietze; Torsten Wuestefeld; Yasmin Paul; Lars Zender; Christian Trautwein; Michael P Manns; Stefan Kubicka
IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas.
Cancer gene therapy 2000;7(10):1315-23.
2000: Christian Trautwein; M Possienke; Hans J Schlitt; Klaus H W Böker; R Horn; Rudolf Raab; Michael P Manns; Georg Brabant
Bone density and metabolism in patients with viral hepatitis and cholestatic liver diseases before and after liver transplantation.
The American journal of gastroenterology 2000;95(9):2343-51.
2000: Torsten Wüstefeld; T Rakemann; Stefan Kubicka; Michael P Manns; Christian Trautwein
Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice.
Hepatology (Baltimore, Md.) 2000;32(3):514-22.
2000: Konrad L Streetz; Ludger Leifeld; D Grundmann; Jan Ramakers; K Eckert; Ulrich Spengler; David A Brenner; Michael P Manns; Christian Trautwein
Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure.
Gastroenterology 2000;119(2):446-60.
2000: Konrad L Streetz; Tom Luedde; Michael P Manns; Christian Trautwein
Interleukin 6 and liver regeneration.
Gut 2000;47(2):309-12.
2000: Stefan Kubicka; K Lenhard Rudolph; M Hanke; MK Tietze; Hans L Tillmann; Christian Trautwein; Michael P Manns
Hepatocellular carcinoma in Germany: a retrospective epidemiological study from a low-endemic area.
Liver 2000;20(4):312-8.
2000: Florian Kühnel; Lars Zender; Yasmin Paul; MK Tietze; Christian Trautwein; Michael P Manns; Stefan Kubicka
NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis.
The Journal of biological chemistry 2000;275(9):6421-7.
2000: C-Thomas Bock; Nisar P Malek; Hans L Tillmann; Michael P Manns; Christian Trautwein
The enhancer I core region contributes to the replication level of hepatitis B virus in vivo and in vitro.
Journal of virology 2000;74(5):2193-202.
2000: Jörg Plümpe; Nisar P Malek; C-Thomas Bock; T Rakemann; Michael P Manns; Christian Trautwein
NF-kappaB determines between apoptosis and proliferation in hepatocytes during liver regeneration.
American journal of physiology. Gastrointestinal and liver physiology 2000;278(1):G173-83.
1999: Christian Trautwein; M Will; Stefan Kubicka; T Rakemann; Peer Flemming; Michael P Manns
2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin E expression.
Oncogene 1999;18(47):6443-53.
1999: Stefan Kubicka; Florian Kühnel; Lars Zender; K Lenhard Rudolph; Jörg Plümpe; Michael P Manns; Christian Trautwein
p53 represses CAAT enhancer-binding protein (C/EBP)-dependent transcription of the albumin gene. A molecular mechanism involved in viral liver infection with implications for hepatocarcinogenesis.
The Journal of biological chemistry 1999;274(45):32137-44.
1999: K Lenhard Rudolph; Christian Trautwein; Stefan Kubicka; T Rakemann; Matthias J Bahr; N Sedlaczek; Detlef Schuppan; Michael P Manns
Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats.
Hepatology (Baltimore, Md.) 1999;30(5):1159-66.
1999: C-Thomas Bock; Hans L Tillmann; Michael P Manns; Christian Trautwein
The pre-S region determines the intracellular localization and appearance of hepatitis B virus.
Hepatology (Baltimore, Md.) 1999;30(2):517-25.
1999: Hans L Tillmann; Christian Trautwein; T Bock; Klaus H W Böker; Elmar Jäckel; M Glowienka; K Oldhafer; I Bruns; Josée Gauthier; Lynn Condreay; H R Raab; Michael P Manns
Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation.
Hepatology (Baltimore, Md.) 1999;30(1):244-56.
1999: Ludger Leifeld; Christian Trautwein; Franz Ludwig Dumoulin; M P Manns; Tilman Sauerbruch; Ulrich Spengler
Enhanced expression of CD80 (B7-1), CD86 (B7-2), and CD40 and their ligands CD28 and CD154 in fulminant hepatic failure.
The American journal of pathology 1999;154(6):1711-20.
1999: Frank Tacke; Patrick Schöffski; Christian Trautwein; Michael U Martin; W Stangel; E Seifried; Michael P Manns; Arnold Ganser; D Petersen
Endogenous serum levels of thrombopoietic cytokines in healthy whole-blood and platelet donors: implications for plateletpheresis.
British journal of haematology 1999;105(2):511-3.
1999: Jörg Plümpe; Konrad L Streetz; Michael P Manns; Christian Trautwein
Tumour necrosis factor alpha--mediator of apoptosis and cell proliferation of hepatocytes.
Italian journal of gastroenterology and hepatology 1999;31(3):235-43.
1999: C-Thomas Bock; Stefan Kubicka; Michael P Manns; Christian Trautwein
Two control elements in the hepatitis B virus S-promoter are important for full promoter activity mediated by CCAAT-binding factor.
Hepatology (Baltimore, Md.) 1999;29(4):1236-47.
1999: Christian Trautwein; Michael P Manns
[Chronic viral hepatitis--diagnosis, therapy and prognosis].
Versicherungsmedizin / herausgegeben von Verband der Lebensversicherungs-Unternehmen e.V. und Verband der Privaten Krankenversicherung e.V 1999;51(1):3-11.
1999: T Rakemann; M Niehof; Stefan Kubicka; M Fischer; Michael P Manns; Stefan Rose-John; Christian Trautwein
The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.
The Journal of biological chemistry 1999;274(3):1257-66.
1998: Cynthia A Bradham; Ting Qian; K Streetz; Christian Trautwein; David A Brenner; John J Lemasters
The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release.
Molecular and cellular biology 1998;18(11):6353-64.
1998: Heiner Wedemeyer; Elmar Jäckel; Jochen Wedemeyer; H Frank; Andreas Schüler; Christian Trautwein; Michael P Manns
[Is combination therapy of chronic hepatitis C with interferon alpha and ribavirin in primary interferon nonresponders indicated?--An analysis of personal experiences and review of the literature].
Zeitschrift für Gastroenterologie 1998;36(9):819-27.
1998: Cynthia A Bradham; Jörg Plümpe; Michael P Manns; David A Brenner; Christian Trautwein
Mechanisms of hepatic toxicity. I. TNF-induced liver injury.
The American journal of physiology 1998;275(3 Pt 1):G387-92.
1998: Hans L Tillmann; S Heringlake; Christian Trautwein; D Meissner; B Nashan; Hans J Schlitt; J Kratochvil; J Hunt; X Qiu; S C Lou; Rudolf Pichlmayr; Michael P Manns
Antibodies against the GB virus C envelope 2 protein before liver transplantation protect against GB virus C de novo infection.
Hepatology (Baltimore, Md.) 1998;28(2):379-84.
1998: S Heringlake; J Ockenga; Hans L Tillmann; Christian Trautwein; D Meissner; Matthias Stoll; J Hunt; CK Jou; N Solomon; Reinhold E Schmidt; Michael P Manns
GB virus C/hepatitis G virus infection: a favorable prognostic factor in human immunodeficiency virus-infected patients?
The Journal of infectious diseases 1998;177(6):1723-6.
1998: Christian Trautwein; T Rakemann; Nisar P Malek; Jörg Plümpe; Gisa Tiegs; Michael P Manns
Concanavalin A-induced liver injury triggers hepatocyte proliferation.
The Journal of clinical investigation 1998;101(9):1960-9.
1998: Christian Trautwein; T Rakemann; David A Brenner; Konrad L Streetz; L Licato; Michael P Manns; Gisa Tiegs
Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice.
Gastroenterology 1998;114(5):1035-45.
1998: Uwe J F Tietge; H H Schmidt; Elmar Jäckel; Christian Trautwein; Michael P Manns
Low molecular weight heparin-induced skin necrosis occurring distant from injection sites and without thrombocytopenia.
Journal of internal medicine 1998;243(4):313-5.
1998: Arved Weimann; Leonard Bastian; W E Bischoff; Martin Grotz; M Hansel; J Lotz; Christian Trautwein; Günter Tusch; Hans J Schlitt; Gerd Regel
Influence of arginine, omega-3 fatty acids and nucleotide-supplemented enteral support on systemic inflammatory response syndrome and multiple organ failure in patients after severe trauma.
Nutrition (Burbank, Los Angeles County, Calif.) 1998;14(2):165-72.
1998: Nisar P Malek; J Pluempe; Stefan Kubicka; M P Manns; Christian Trautwein
Molecular mechanisms of TNF receptor-mediated signaling.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;147():97-106.
1997: C-Thomas Bock; Hans L Tillmann; H J Maschek; Michael P Manns; Christian Trautwein
A preS mutation isolated from a patient with chronic hepatitis B infection leads to virus retention and misassembly.
Gastroenterology 1997;113(6):1976-82.
1997: Siegfried Wagner; Winfried Beil; J Westermann; R P Logan; C-Thomas Bock; Christian Trautwein; Jörg S Bleck; Michael P Manns
Regulation of gastric epithelial cell growth by Helicobacter pylori: offdence for a major role of apoptosis.
Gastroenterology 1997;113(6):1836-47.
1997: J Ockenga; Hans L Tillmann; Christian Trautwein; M Stoll; Michael P Manns; R E Schmidt
Hepatitis B and C in HIV-infected patients. Prevalence and prognostic value.
Journal of hepatology 1997;27(1):18-24.
1997: M Niehof; Michael P Manns; Christian Trautwein
CREB controls LAP/C/EBP beta transcription.
Molecular and cellular biology 1997;17(7):3600-13.
1997: Stefan Kubicka; Christian Trautwein; M Niehof; Michael P Manns
Target gene modulation in hepatocellular carcinomas by decreased DNA-binding of p53 mutations.
Hepatology (Baltimore, Md.) 1997;25(4):867-73.
1997: Christian Trautwein; Michael P Manns
[Chronic hepatitis].
Der Internist 1997;38(3):283-95.
1997: Johann Ockenga; Matthias Stoll; Hans L Tillmann; Christian Trautwein; Michael P Manns; Reinhold E Schmidt
[Coinfection of hepatitis B and C in HIV-infected patients].
Wiener medizinische Wochenschrift (1946) 1997;147(19-20):439-42.
1997: Christian Trautwein; T Rakemann; Petra Obermayer-Straub; M Niehof; Michael P Manns
Differences in the regulation of cytochrome P450 family members during liver regeneration.
Journal of hepatology 1997;26(1):48-54.
1997: Klaus H W Böker; G Dalley; Matthias J Bahr; HG Maschek; Hans L Tillmann; Christian Trautwein; K Oldhaver; U Bode; Rudolf Pichlmayr; Michael P Manns
Long-term outcome of hepatitis C virus infection after liver transplantation.
Hepatology (Baltimore, Md.) 1997;25(1):203-10.
1996: S Heringlake; S Osterkamp; Christian Trautwein; Hans L Tillmann; Klaus H W Böker; S Muerhoff; I K Mushahwar; Gerhard Hunsmann; Michael P Manns
Association between fulminant hepatic failure and a strain of GBV virus C.
Lancet 1996;348(9042):1626-9.
1996: S Heringlake; Hans L Tillmann; P Cordes-Temme; Christian Trautwein; Gerhard Hunsmann; Michael P Manns
GBV-C/HGV is not the major cause of autoimmune hepatitis.
Journal of hepatology 1996;25(6):980-4.
1996: Nisar P Malek; K Ocran; Uwe J F Tietge; HG Maschek; Klaus F Gratz; Christian Trautwein; Siegfried Wagner; Michael P Manns
A case of the yellow nail syndrome associated with massive chylous ascites, pleural and pericardial effusions.
Zeitschrift für Gastroenterologie 1996;34(11):763-6.
1996: Christian Trautwein; T Rakemann; Antonello Pietrangelo; Jörg Plümpe; Giuliana Montosi; Michael P Manns
C/EBP-beta/LAP controls down-regulation of albumin gene transcription during liver regeneration.
The Journal of biological chemistry 1996;271(36):22262-70.
1996: Leonard Bastian; Arved Weimann; Gerd Regel; Christian Trautwein; Harald Tscherne
[Feasibility and complications in early enteral nutrition of severely injured polytrauma patients via duodenal tubes].
Der Unfallchirurg 1996;99(9):642-9.
1996: Christian Trautwein; H Schrem; Hans L Tillmann; Stefan Kubicka; D Walker; Klaus H W Böker; HG Maschek; Rudolf Pichlmayr; Michael P Manns
Hepatitis B virus mutations in the pre-S genome before and after liver transplantation.
Hepatology (Baltimore, Md.) 1996;24(3):482-8.
1996: M Krüger; Hans L Tillmann; Christian Trautwein; U Bode; Karl J Oldhafer; HG Maschek; Klaus H W Böker; C E Broelsch; Rudolf Pichlmayr; Michael P Manns
Famciclovir treatment of hepatitis B virus recurrence after liver transplantation: a pilot study.
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 1996;2(4):253-62.
1996: Christian Trautwein; T Rakemann; M Niehof; S Rose-John; Michael P Manns
Acute-phase response factor, increased binding, and target gene transcription during liver regeneration.
Gastroenterology 1996;110(6):1854-62.
1996: Hans L Tillmann; M Krüger; U Bode; Christian Trautwein
[The problem of viral hepatitis in transplantation medicine].
Der Internist 1996;37(3):240-9.
1996: Stephan C Bischoff; Jochen Wedemeyer; A Herrmann; Peter N Meier; Christian Trautwein; Y Cetin; HG Maschek; M Stolte; Michael Gebel; Michael P Manns
Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease.
Histopathology 1996;28(1):1-13.
1995: Stefan Kubicka; Christian Trautwein; H Schrem; Hans L Tillmann; Michael P Manns
Low incidence of p53 mutations in European hepatocellular carcinomas with heterogeneous mutation as a rare event.
Journal of hepatology 1995;23(4):412-9.
1995: Hans L Tillmann; Christian Trautwein; D Walker; K Michitaka; Stefan Kubicka; Klaus H W Böker; Michael P Manns
Clinical relevance of mutations in the precore genome of the hepatitis B virus.
Gut 1995;37(4):568-73.
1995: Christian Trautwein; Michael P Manns
[Liver diseases in the elderly].
Der Internist 1995;36(7):668-76.
1995: Christian Trautwein; D L Walker; Jörg Plümpe; Michael P Manns
Transactivation of LAP/NF-IL6 is mediated by an acidic domain in the N-terminal part of the protein.
The Journal of biological chemistry 1995;270(25):15130-6.
1995: Christian Trautwein; G Kiral; Hans L Tillmann; H Witteler; G Michel; Michael P Manns
Risk factors and prevalence of hepatitis E in German immigrants from the former Soviet Union.
Journal of medical virology 1995;45(4):429-34.
1995: Christian Trautwein; M Davies; E Elias; A Strain; Michael P Manns
Extracellular matrix proteins modulate cytochrome P450 2D6 expression in human hepatocytes.
Journal of hepatology 1995;22(1):50-6.
1994: Christian Trautwein; Klaus H W Böker; Michael P Manns
Hepatocyte and immune system: acute phase reaction as a contribution to early defence mechanisms.
Gut 1994;35(9):1163-6.
1994: T Philipp; Marilena Durazzo; Christian Trautwein; B Alex; P Straub; J G Lamb; E F Johnson; Robert H Tukey; Michael P Manns
Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D.
Lancet 1994;344(8922):578-81.
1992: Barbara Rehermann; Christian Trautwein; Klaus H W Böker; Michael P Manns
Interleukin-6 in liver diseases.
Journal of hepatology 1992;15(3):277-80.