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Paola Bossù

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Francesca Salani; Gianfranco Spalletta; Francesca Assogna; Federica Bizzoni; Carlo Caltagirone; Antonio Ciaramella; Paola Bossù
Increased expression of Interleukin-18 receptor in blood cells of subjects with Mild Cognitive Impairment and Alzheimer's disease.
Ilaria Palladino; Ivo Alex Rubino; Francesca Salani; Gianfranco Spalletta; Carlo Caltagirone; Antonio Ciaramella; Sabrina Fagioli; Paola Bossù
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia.
Stefania Mondello; Kara Schmid; Frank C Tortella; Kevin K W Wang; Paola Bossù; Sheila Catani; Antonio Ciaramella; Mariagrazia D'Ippolito; Andrea Gabrielli; Ronald L Hayes; Andreas Jeromin; Rita Formisano
Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury.

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All Publications

2013: Francesca Salani; Gianfranco Spalletta; Francesca Assogna; Federica Bizzoni; Carlo Caltagirone; Antonio Ciaramella; Paola Bossù
Increased expression of Interleukin-18 receptor in blood cells of subjects with Mild Cognitive Impairment and Alzheimer's disease.
Cytokine 2013;61(2):360-3.
2012: Ilaria Palladino; Ivo Alex Rubino; Francesca Salani; Gianfranco Spalletta; Carlo Caltagirone; Antonio Ciaramella; Sabrina Fagioli; Paola Bossù
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia.
Journal of neuroinflammation 2012;9():206.
2012: Stefania Mondello; Kara Schmid; Frank C Tortella; Kevin K W Wang; Paola Bossù; Sheila Catani; Antonio Ciaramella; Mariagrazia D'Ippolito; Andrea Gabrielli; Ronald L Hayes; Andreas Jeromin; Rita Formisano
Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury.
Brain injury : [BI] 2012;26(13-14):1629-35.
2012: Paola Bossù; Carlo Caltagirone; Paola Caporali; Debora Cutuli; Paola De Bartolo; Francesca Gelfo; Daniela Laricchiuta; Ilaria Palladino; Francesco Angelucci; Laura Petrosini
A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18.
Journal of neuroinflammation 2012;9():101.
2012: Fabrizio Piras; Francesca Salani; Paola Bossù; Carlo Caltagirone; Gianfranco Spalletta
High serum levels of transforming growth factor β1 are associated with increased cortical thickness in cingulate and right frontal areas in healthy subjects.
Journal of neuroinflammation 2012;9():42.
2011: Paolo Gravina; Ilaria Spoletini; Silvia Masini; Alessandra Valentini; Diego Vanni; Eleonora Paladini; Paola Bossù; Carlo Caltagirone; Giorgio Federici; Gianfranco Spalletta; Sergio Bernardini
Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia.
Psychiatry research 2011;187(3):454-6.
2011: Paola Bossù; Carlo Caltagirone; Daniela Galimberti; Alessandro Padovani; Francesca Salani; Elio Scarpini; Gianfranco Spalletta; Antonella Alberici; Silvana Archetti; Giuseppe Bellelli; Barbara Borroni
Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients.
Journal of neuroinflammation 2011;8():65.
2011: Antonio Ciaramella; Gianfranco Spalletta; Federica Bizzoni; Francesca Salani; Carlo Caltagirone; Paola Bossù
Effect of age on surface molecules and cytokine expression in human dendritic cells.
Cellular immunology 2011;269(2):82-9.
2011: Francesco Angelucci; Nicoletta Croce; Gianfranco Spalletta; Vincenzo Dinallo; Paolo Gravina; Paola Bossù; Giorgio Federici; Carlo Caltagirone; Sergio Bernardini
Paroxetine rapidly modulates the expression of brain-derived neurotrophic factor mRNA and protein in a human glioblastoma-astrocytoma cell line.
Pharmacology 2011;87(1-2):5-10.
2010: Gianfranco Spalletta; D W Morris; F Angelucci; I A Rubino; I Spoletini; P Bria; G Martinotti; A Siracusano; Giuseppina Bonaviri; S Bernardini; Carlo Caltagirone; Paola Bossù; G Donohoe; M Gill; A P Corvin
BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia.
European psychiatry : the journal of the Association of European Psychiatrists 2010;25(6):311-3.
2010: Francesco Angelucci; Gianfranco Spalletta; Fulvia di Iulio; Antonio Ciaramella; Francesca Salani; Luca Colantoni; Ambra Erika Varsi; Walter Gianni; Giuseppe Sancesario; Carlo Caltagirone; Paola Bossù
Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels.
Current Alzheimer research 2010;7(1):15-20.
2010: Andrea Cherubini; Ilaria Spoletini; Patrice Péran; Giacomo Luccichenti; Margherita Di Paola; Giuseppe Sancesario; Walter Gianni; Franco Giubilei; Paola Bossù; Umberto Sabatini; Carlo Caltagirone; Gianfranco Spalletta
A multimodal MRI investigation of the subventricular zone in mild cognitive impairment and Alzheimer's disease patients.
Neuroscience letters 2010;469(2):214-8.
2010: Andrea Cherubini; Patrice Péran; Ilaria Spoletini; Margherita Di Paola; Fulvia Di Iulio; Gisela Elizabeth Hagberg; Giuseppe Sancesario; Walter Gianni; Paola Bossù; Carlo Caltagirone; Umberto Sabatini; Gianfranco Spalletta
Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer's disease patients.
Journal of Alzheimer's disease : JAD 2010;19(4):1273-82.
2010: Antonio Ciaramella; Federica Bizzoni; Francesca Salani; Diego Vanni; Gianfranco Spalletta; Nunzia Sanarico; Silvia Vendetti; Carlo Caltagirone; Paola Bossù
Increased pro-inflammatory response by dendritic cells from patients with Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2010;19(2):559-72.
2009: Francesco Angelucci; Paola De Bartolo; Francesca Gelfo; Francesca Foti; Debora Cutuli; Paola Bossù; Carlo Caltagirone; Laura Petrosini
Increased concentrations of nerve growth factor and brain-derived neurotrophic factor in the rat cerebellum after exposure to environmental enrichment.
Cerebellum (London, England) 2009;8(4):499-506.
2009: Paola Bossù; Francesca Salani; Claudia Cacciari; Livio Picchetto; Marina Cao; Federica Bizzoni; Maurizia Rasura; Carlo Caltagirone; Robert G Robinson; Francesco Orzi; Gianfranco Spalletta
Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke.
Current neurovascular research 2009;6(3):163-70.
2009: Antonio Ciaramella; Nunzia Sanarico; Federica Bizzoni; Maria Luisa Moro; Francesca Salani; Giuseppe Scapigliati; Gianfranco Spalletta; Carlo Caltagirone; Paola Bossù
Amyloid beta peptide promotes differentiation of pro-inflammatory human myeloid dendritic cells.
Neurobiology of aging 2009;30(2):210-21.
2009: Francesco Angelucci; Sergio Bernardini; Paolo Gravina; Lorenza Bellincampi; Alberto Trequattrini; Fulvia Di Iulio; Diego Vanni; Giorgio Federici; Carlo Caltagirone; Paola Bossù; Gianfranco Spalletta
Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study.
Journal of Alzheimer's disease : JAD 2009;17(1):203-11.
2008: Paola Bossù; Antonio Ciaramella; Francesca Salani; Federica Bizzoni; Erika Varsi; Fulvia Di Iulio; Franco Giubilei; Walter Gianni; Alberto Trequattrini; Maria Luisa Moro; Sergio Bernardini; Carlo Caltagirone; Gianfranco Spalletta
Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment.
Brain, behavior, and immunity 2008;22(4):487-92.
2008: Ilaria Spoletini; Walter Gianni; Lazzaro Repetto; Pietro Bria; Carlo Caltagirone; Paola Bossù; Gianfranco Spalletta
Depression and cancer: an unexplored and unresolved emergent issue in elderly patients.
Critical reviews in oncology/hematology 2008;65(2):143-55.
2007: Gianfranco Spalletta; Sergio Bernardini; Lorenza Bellincampi; Giorgio Federici; Alberto Trequattrini; Fabrizio Ciappi; Pietro Bria; Carlo Caltagirone; Paola Bossù
Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2007;15(10):879-87.
2007: Paola Bossù; Antonio Ciaramella; Maria Luisa Moro; Lorenza Bellincampi; Sergio Bernardini; Giorgio Federici; Alberto Trequattrini; Fabio Macciardi; Ilaria Spoletini; Fulvia Di Iulio; Carlo Caltagirone; Gianfranco Spalletta
Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2007;78(8):807-11.
2006: Gianfranco Spalletta; Paola Bossù; Antonio Ciaramella; Pietro Bria; Carlo Caltagirone; R G Robinson
The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines.
Molecular psychiatry 2006;11(11):984-91.
2006: Nunzia Sanarico; Antonio Ciaramella; Alessandra Sacchi; Daniela Bernasconi; Paola Bossù; Francesca Mariani; Vittorio Colizzi; Silvia Vendetti
Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response.
Journal of leukocyte biology 2006;80(3):555-62.
2005: Francesco Buonocore; Maria Forlenza; Elisa Randelli; Stefania Benedetti; Paola Bossù; Sabrina Meloni; Christopher J Secombes; Massimo Mazzini; Giuseppe Scapigliati
Biological activity of sea bass (Dicentrarchus labrax L.) recombinant interleukin-1beta.
Marine biotechnology (New York, N.Y.) 2005;7(6):609-17.
2005: Sergio Bernardini; Lorenza Bellincampi; Sabrina Ballerini; Giorgio Federici; Roberta Iori; Alberto Trequattrini; Fabrizio Ciappi; Francesca Baldinetti; Paola Bossù; Carlo Caltagirone; Gianfranco Spalletta
Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 allele.
Clinical chemistry 2005;51(6):944-51.
2004: Stefano Porzio; Paola Bossù; Paolo Ruggiero; Diana Boraschi; Aldo Tagliabue
Mucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteria.
BMC biotechnology 2004;4():27.
2004: Giuseppe Scapigliati; Susan Costantini; Giovanni Colonna; Angelo M Facchiano; Francesco Buonocore; Paola Bossù; Charles Cunningham; Jason W Holland; Christopher J Secombes
Modelling of fish interleukin-1 and its receptor.
Developmental and comparative immunology 2004;28(5):429-41.
2003: Paola Bossù; Detlef Neumann; Elda Del Giudice; Antonio Ciaramella; Isabelle Gloaguen; Giamila Fantuzzi; Charles A Dinarello; Emma Di Carlo; Piero Musiani; Pier Luigi Meroni; Gianfranco Caselli; Paolo Ruggiero; Diana Boraschi
IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14181-6.
2003: Susanna Ricci; Giovanni Macchia; Paolo Ruggiero; Tiziana Maggi; Paola Bossù; Li Xu; Donata Medaglini; Aldo Tagliabue; Lennart Hammarström; Gianni Pozzi; Diana Boraschi
In vivo mucosal delivery of bioactive human interleukin 1 receptor antagonist produced by Streptococcus gordonii.
BMC biotechnology 2003;3():15.
2003: Giuseppe Scapigliati; Sabrina Meloni; Francesco Buonocore; Paola Bossù; Daniela Prugnoli; Christopher J Secombes
Immunopurification of B lymphocytes from sea bass Dicentrarchus labrax (L.).
Marine biotechnology (New York, N.Y.) 2003;5(3):214-21.
2002: Paolo Michieli; Silvia Cavassa; Cristina Basilico; Annarita De Luca; Massimiliano Mazzone; Cinzia Asti; Riccardo Chiusaroli; Mario Guglielmi; Paola Bossù; Francesco Colotta; Gianfranco Caselli; paolo comoglio
An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity.
Nature biotechnology 2002;20(5):488-95.
2001: E D Giudice; Antonio Ciaramella; N Balestro; Detlef Neumann; P G Romano; MP Cesaroni; Giovanni Maurizi; Paolo Ruggiero; Diana Boraschi; Paola Bossù
Neutrophil apoptosis in autoimmune Fas-defective MRL lpr/lpr mice.
European cytokine network 2001;12(3):510-7.
2001: Rita Casadio; E Frigimelica; Paola Bossù; Detlef Neumann; Michael U Martin; Aldo Tagliabue; Diana Boraschi
Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1beta/IL-1R(I) complex.
FEBS letters 2001;499(1-2):65-8.
2001: Detlef Neumann; Elda Del Giudice; Antonio Ciaramella; Diana Boraschi; Paola Bossù
Lymphocytes from autoimmune MRL lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chain.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3757-62.
2001: Paola Bossù; E del Grosso; MP Cesaroni; Giovanni Maurizi; N Balestro; A Stoppacciaro; Elda Del Giudice; Paolo Ruggiero; Diana Boraschi
Balance between autocrine interleukin-1beta and caspases defines life versus death of polymorphonuclear cells.
European cytokine network 2001;12(1):177-86.
2000: Paola Bossù; Elda Del Giudice; Antonio Ciaramella; Detlef Neumann; Diana Boraschi
IL-18 and IL-18 receptors in the development of autoimmunity.
European cytokine network 2000;11(3):515-6.
2000: Paola Bossù; Marco Vanoni; Valeria Wanke; MP Cesaroni; F Tropea; Gabriella Melillo; Cinzia Asti; Stefano Porzio; Paolo Ruggiero; Vito Di Cioccio; Giovanni Maurizi; A Ciabini; Lilia Alberghina
A dominant negative RAS-specific guanine nucleotide exchange factor reverses neoplastic phenotype in K-ras transformed mouse fibroblasts.
Oncogene 2000;19(17):2147-54.
1997: Paola Bossù; Paolo Ruggiero; Giovanni Macchia; Giovanni Maurizi; Cinzia Bizzarri; Detlef Neumann; Aldo Tagliabue; Diana Boraschi
Interaction between interleukin-1 and ciliary neurotrophic factor in the regulation of neuroblastoma cell functions.
European cytokine network 1997;8(4):367-74.
1997: Paolo Ruggiero; Paola Bossù; Giovanni Macchia; E Del Grosso; Vilma Sabbatini; Riccardo Bertini; Antonella Colagrande; Cinzia Bizzarri; Giovanni Maurizi; Vito Di Cioccio; G D'Andrea; A Di Giulio; F Frigerio; Renata Grifantini; G Grandi; Aldo Tagliabue; Diana Boraschi
Inhibitory activity of IL-1 receptor antagonist depends on the balance between binding capacity for IL-1 receptor type 1 and IL-1 receptor type II.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3881-7.
1997: Giovanni Maurizi; Vito Di Cioccio; Giovanni Macchia; Paola Bossù; Cinzia Bizzarri; U Visconti; Diana Boraschi; Aldo Tagliabue; Paolo Ruggiero
Purification of human recombinant interleukin 1 receptor antagonist proteins upon Bacillus subtilis sporulation.
Protein expression and purification 1997;9(2):219-27.
1995: Paola Bossù; U Visconti; Paolo Ruggiero; Giovanni Macchia; M Muda; Riccardo Bertini; Cinzia Bizzarri; A Colagrande; Vilma Sabbatini; Giovanni Maurizi
Transfected type II interleukin-1 receptor impairs responsiveness of human keratinocytes to interleukin-1.
The American journal of pathology 1995;147(6):1852-61.
1995: Diana Boraschi; Paola Bossù; Paolo Ruggiero; Aldo Tagliabue; Riccardo Bertini; Giovanni Macchia; C Gasbarro; Luigi Pellegrini; Gabriella Melillo; E Ulisse; U Visconti; Cinzia Bizzarri; E Del Grosso; A R Mackay; G Frascotti; F Frigerio; Renata Grifantini; G Grandi
Mapping of receptor binding sites on IL-1 beta by reconstruction of IL-1ra-like domains.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4719-25.
1995: Cinzia Bizzarri; Riccardo Bertini; Paola Bossù; S Sozzani; A Mantovani; J Van Damme; Aldo Tagliabue; Diana Boraschi
Single-cell analysis of macrophage chemotactic protein-1-regulated cytosolic Ca2+ increase in human adherent monocytes.
Blood 1995;86(6):2388-94.
1991: Diana Boraschi; L Villa; P Ghiara; R Presentini; Paola Bossù; Stefano Censini; D Nucci; A Massone; R Rossi; H D Flad
Differential inhibition of IL-1 beta activities and receptor binding by monoclonal antibodies mapping within a discrete region of the protein.
Lymphokine and cytokine research 1991;10(5):377-84.
1990: Antonello Podda; L Nencioni; Maria Teresa De Magistris; A Di Tommaso; Paola Bossù; Sandra Nuti; P Pileri; S Peppoloni; M Bugnoli; Paolo Ruggiero
Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G.
The Journal of experimental medicine 1990;172(3):861-8.
1990: Diana Boraschi; L Villa; G Volpini; Paola Bossù; Stefano Censini; P Ghiara; G Scapigliat; L Nencioni; M Bartalini; G Matteucci
Differential activity of interleukin 1 alpha and interleukin 1 beta in the stimulation of the immune response in vivo.
European journal of immunology 1990;20(2):317-21.
1990: P Ghiara; G Scapigliati; Stefano Censini; M Bartalini; Paola Bossù; D Armellini; Sandra Nuti; G Volpini; R Dallai; Diana Boraschi
IL-1 receptor subtypes possess distinct binding properties for IL-1 alpha and IL-1 beta.
Progress in clinical and biological research 1990;349():271-84.
1989: M C Casagli; M G Borri; M Bigio; R Rossi; D Nucci; Paola Bossù; Diana Boraschi; G Antoni
Different conformation of purified human recombinant interleukin 1 beta from Escherichia coli and Saccharomyces cerevisiae is related to different level of biological activity.
Biochemical and biophysical research communications 1989;162(1):357-63.
1989: S Peppoloni; Paola Bossù; Diana Boraschi; Aldo Tagliabue
A short synthetic peptide fragment of human interleukin-1 beta increases both human and murine natural killer activity.
Natural immunity and cell growth regulation 1989;8(1):10-9.
1988: Diana Boraschi; L Nencioni; L Villa; Stefano Censini; Paola Bossù; P Ghiara; R Presentini; F Perin; Daniela Frasca; G Doria
In vivo stimulation and restoration of the immune response by the noninflammatory fragment 163-171 of human interleukin 1 beta.
The Journal of experimental medicine 1988;168(2):675-86.