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James Treanor

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Robert M Rzasa; James J S Treanor; Xiaoning Zhao; Wenge Zhong; Kristin L Andrews; Ning Chen; Samer Chmait; James R Falsey; Essa Hu; Adrie D Jones; Steven W Louie; Amy Porter; Shannon Rumfelt; Jennifer R Allen
Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.
Markian M Stec; Yunxin Bo; Partha P Chakrabarti; Lillian Liao; Mqhele Ncube; Nuria A Tamayo; Rami Tamir; Narender R Gavva; James J S Treanor; Mark H Norman
Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists.
Narender R Gavva; James J S Treanor; Andras Garami; Liang Fang; Sekhar Surapaneni; Anna Akrami; Francisco Alvarez; Annette Bak; Mary Darling; Anu Gore; Graham R Jang; James P Kesslak; Liyun Ni; Mark H Norman; Gabrielle Palluconi; Mark J Rose; Margaret Salfi; Edward Tan; Andrej A Romanovsky; Christopher Banfield; Gudarz Davar
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans.

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All Publications

2012: Robert M Rzasa; James J S Treanor; Xiaoning Zhao; Wenge Zhong; Kristin L Andrews; Ning Chen; Samer Chmait; James R Falsey; Essa Hu; Adrie D Jones; Steven W Louie; Amy Porter; Shannon Rumfelt; Jennifer R Allen
Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.
Bioorganic & medicinal chemistry letters 2012;22(24):7371-5.
2008: Markian M Stec; Yunxin Bo; Partha P Chakrabarti; Lillian Liao; Mqhele Ncube; Nuria A Tamayo; Rami Tamir; Narender R Gavva; James J S Treanor; Mark H Norman
Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2008;18(18):5118-22.
2008: Narender R Gavva; James J S Treanor; Andras Garami; Liang Fang; Sekhar Surapaneni; Anna Akrami; Francisco Alvarez; Annette Bak; Mary Darling; Anu Gore; Graham R Jang; James P Kesslak; Liyun Ni; Mark H Norman; Gabrielle Palluconi; Mark J Rose; Margaret Salfi; Edward Tan; Andrej A Romanovsky; Christopher Banfield; Gudarz Davar
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans.
Pain 2008;136(1-2):202-10.
2008: Elizabeth M Doherty; Daniel Retz; Narender R Gavva; Rami Tamir; James J S Treanor; Mark H Norman
4-Aminopyrimidine tetrahydronaphthols: a series of novel vanilloid receptor-1 antagonists with improved solubility properties.
Bioorganic & medicinal chemistry letters 2008;18(6):1830-4.
2007: Xianghong Wang; Partha P Chakrabarti; Vassil I Ognyanov; Liping H Pettus; Rami Tamir; Helming Tan; Phi Tang; James J S Treanor; Narender R Gavva; Mark H Norman
Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility.
Bioorganic & medicinal chemistry letters 2007;17(23):6539-45.
2007: Vijay K Gore; Vu V Ma; Rami Tamir; Narender R Gavva; James J S Treanor; Mark H Norman
Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2007;17(21):5825-30.
2007: Narender R Gavva; Anthony W Bannon; David N Hovland; Sonya G Lehto; Lana Klionsky; Sekhar Surapaneni; David C Immke; Charles Henley; Leyla Arik; Annette Bak; James Davis; Nadia Ernst; Gal Hever; Rongzhen Kuang; Licheng Shi; Rami Tamir; Jue Wang; Weiya Wang; Gary Zajic; Dawn Zhu; Mark H Norman; Jean-Claude Louis; Ella Magal; James J S Treanor
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade.
The Journal of pharmacology and experimental therapeutics 2007;323(1):128-37.
2007: Hui-Ling Wang; Jodie Katon; Chenera Balan; Anthony W Bannon; Charles Bernard; Elizabeth M Doherty; Celia Dominguez; Narender R Gavva; Vijay K Gore; Vu V Ma; Nobuko Nishimura; Sekhar Surapaneni; Phi Tang; Rami Tamir; Oliver Thiel; James J S Treanor; Mark H Norman
Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.
Journal of medicinal chemistry 2007;50(15):3528-39.
2007: Elizabeth M Doherty; Christopher Fotsch; Anthony W Bannon; Yunxin Bo; Ning Chen; Celia Dominguez; James Falsey; Narender R Gavva; Jodie Katon; Thomas Nixey; Vassil I Ognyanov; Liping Pettus; Robert M Rzasa; Markian Stec; Sekhar Surapaneni; Rami Tamir; Jiawang Zhu; James J S Treanor; Mark H Norman
Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate.
Journal of medicinal chemistry 2007;50(15):3515-27.
2007: Mark H Norman; Jiawang Zhu; Christopher Fotsch; Yunxin Bo; Ning Chen; Partha P Chakrabarti; Elizabeth M Doherty; Narender R Gavva; Nobuko Nishimura; Thomas Nixey; Vassil I Ognyanov; Robert M Rzasa; Markian Stec; Sekhar Surapaneni; Rami Tamir; Vellarkad Viswanadhan; James J S Treanor
Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.
Journal of medicinal chemistry 2007;50(15):3497-514.
2007: Alexandre A Steiner; Victoria F Turek; Maria C Almeida; Jeffrey J Burmeister; Daniela L Oliveira; Jennifer L Roberts; Anthony W Bannon; Mark H Norman; Jean-Claude Louis; James J S Treanor; Narender R Gavva; Andrej A Romanovsky
Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(28):7459-68.
2007: Narender R Gavva; Anthony W Bannon; Sekhar Surapaneni; David N Hovland; Sonya G Lehto; Anu Gore; Todd Juan; Hong Deng; Bora Han; Lana Klionsky; Rongzhen Kuang; April Le; Rami Tamir; Jue Wang; Brad Youngblood; Dawn Zhu; Mark H Norman; Ella Magal; James J S Treanor; Jean-Claude Louis
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(13):3366-74.
2006: Lana Klionsky; Rami Tamir; Bob Holzinger; Xiaojuan Bi; Jane Talvenheimo; Helen Kim; Frank Martin; Jean-Claude Louis; James J S Treanor; Narender R Gavva
A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation.
The Journal of pharmacology and experimental therapeutics 2006;319(1):192-8.
2006: Vassil I Ognyanov; Chenera Balan; Anthony W Bannon; Yunxin Bo; Celia Dominguez; Christopher Fotsch; Vijay K Gore; Lana Klionsky; Vu V Ma; Yi-Xin Qian; Rami Tamir; Xianghong Wang; Ning Xi; Shimin Xu; Dawn Zhu; Narender R Gavva; James J S Treanor; Mark H Norman
Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.
Journal of medicinal chemistry 2006;49(12):3719-42.
2005: Ning Xi; Yunxin Bo; Elizabeth M Doherty; Christopher Fotsch; Narender R Gavva; Nianhe Han; Randall W Hungate; Lana Klionsky; Qingyian Liu; Rami Tamir; Shimin Xu; James J S Treanor; Mark H Norman
Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists.
Bioorganic & medicinal chemistry letters 2005;15(23):5211-7.
2005: Narender R Gavva; Rami Tamir; Lana Klionsky; Mark H Norman; Jean-Claude Louis; Kenneth D Wild; James J S Treanor
Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1.
Molecular pharmacology 2005;68(6):1524-33.
2005: Narender R Gavva; Rami Tamir; Yusheng Qu; Lana Klionsky; Tie J Zhang; David C Immke; Judy Wang; Dawn Zhu; Todd W Vanderah; Frank Porreca; Elizabeth M Doherty; Mark H Norman; Kenneth D Wild; Anthony W Bannon; Jean-Claude Louis; James J S Treanor
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
The Journal of pharmacology and experimental therapeutics 2005;313(1):474-84.
2005: Elizabeth M Doherty; Christopher Fotsch; Yunxin Bo; Partha P Chakrabarti; Ning Chen; Narender R Gavva; Nianhe Han; Michael G Kelly; John Kincaid; Lana Klionsky; Qingyian Liu; Vassil I Ognyanov; Rami Tamir; Xianghong Wang; Jiawang Zhu; Mark H Norman; James J S Treanor
Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.
Journal of medicinal chemistry 2005;48(1):71-90.
2004: Narender R Gavva; Lana Klionsky; Yusheng Qu; Licheng Shi; Rami Tamir; Steve Edenson; Tie J Zhang; Vellarkad Viswanadhan; Attila Toth; Larry V Pearce; Todd W Vanderah; Frank Porreca; Peter M Blumberg; Jack Lile; Yax Sun; Kenneth D Wild; Jean-Claude Louis; James J S Treanor
Molecular determinants of vanilloid sensitivity in TRPV1.
The Journal of biological chemistry 2004;279(19):20283-95.
2001: Noemi Kedei; Tamas Szabo; Jack Lile; James J S Treanor; Zoltan Olah; Michael Iadarola; Peter M Blumberg
Analysis of the native quaternary structure of vanilloid receptor 1.
The Journal of biological chemistry 2001;276(30):28613-9.
2000: G M Rishton; D M Retz; P A Tempest; J Novotny; S Kahn; James J S Treanor; Jack Lile; Martin Citron
Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease.
Journal of medicinal chemistry 2000;43(12):2297-9.
1999: Robert Vassar; BD Bennett; Safura Babu-Khan; S Kahn; E A Mendiaz; Paul E Denis; David B Teplow; S Ross; P Amarante; R Loeloff; Y Luo; S Fisher; J Fuller; S Edenson; Jack Lile; Mark Jarosinski; Anja Leona Biere; E Curran; TL Burgess; Jean-Claude Louis; F Collins; James J S Treanor; G Rogers; Martin Citron
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Science (New York, N.Y.) 1999;286(5440):735-41.
1998: RY Xu; K Pong; Y Yu; D Chang; S Liu; Jack Lile; James J S Treanor; KD Beck; Jean-Claude Louis
Characterization of two distinct monoclonal antibodies specific for glial cell line-derived neurotrophic factor.
Journal of neurochemistry 1998;70(4):1383-93.