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Michel Tremblay

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Kelly A Pike; Michel L Tremblay
Regulating naïve and memory CD8 T cell homeostasis--a role for protein tyrosine phosphatases.
Katherine E Horn; Jean-François Bouchard; C Andrew Chapman; Delphine Gobert; Bassam N Hamam; Ronald J Racine; Edward S Ruthazer; Katherine M Thompson; Michel L Tremblay; Noriko Uetani; Chia-Lun Wu; Bin Xu; Timothy E Kennedy
Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity.
Charles V Rajadurai; Matthew Stuible; Michel L Tremblay; Richard Vaillancourt; Kossay Zaoui; Dongmei Zuo; Serhiy Havrylov; Monica A Naujokas; Morag Park
Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia.

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All Publications

2013: Kelly A Pike; Michel L Tremblay
Regulating naïve and memory CD8 T cell homeostasis--a role for protein tyrosine phosphatases.
The FEBS journal 2013;280(2):432-44.
2012: Katherine E Horn; Jean-François Bouchard; C Andrew Chapman; Delphine Gobert; Bassam N Hamam; Ronald J Racine; Edward S Ruthazer; Katherine M Thompson; Michel L Tremblay; Noriko Uetani; Chia-Lun Wu; Bin Xu; Timothy E Kennedy
Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity.
Journal of neurochemistry 2012;122(1):147-61.
2012: Charles V Rajadurai; Matthew Stuible; Michel L Tremblay; Richard Vaillancourt; Kossay Zaoui; Dongmei Zuo; Serhiy Havrylov; Monica A Naujokas; Morag Park
Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia.
Journal of cell science 2012;125(Pt 12):2940-53.
2012: Julie St-Pierre; Michel L Tremblay
Modulation of leptin resistance by protein tyrosine phosphatases.
Cell metabolism 2012;15(3):292-7.
2012: Karen M Doody; Janet E Henderson; Ailian Li; Marilène Paquet; Stéphanie Bussières-Marmen; Michel L Tremblay
T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice.
Arthritis and rheumatism 2012;64(3):752-61.
2012: Francis Robert; Michel L Tremblay; Dantong Wang; Simon S Wing; Aouod Agenor; Regina Cencic; Sergio DiMarco; Imed-Eddine Gallouzi; Siegfried Hekimi; John R Mills; Jerry Pelletier
Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival.
Cancer research 2012;72(3):747-56.
2012: David P Labbé; Serge Hardy; Michel L Tremblay
Protein tyrosine phosphatases in cancer: friends and foes!
Progress in molecular biology and translational science 2012;106():253-306.
2012: Serge Hardy; Sofi G Julien; Michel L Tremblay
Impact of oncogenic protein tyrosine phosphatases in cancer.
Anti-cancer agents in medicinal chemistry 2012;12(1):4-18.
2011: Karim El-Kouhen; Michel L Tremblay
PTPMT1: connecting cardiolipin biosynthesis to mitochondrial function.
Cell metabolism 2011;13(6):615-7.
2010: Matthew Stuible; Michel L Tremblay
In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis.
Trends in cell biology 2010;20(11):672-9.
2010: Serge Hardy; Nau Nau Wong; William J Muller; Morag Park; Michel L Tremblay
Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression.
Cancer research 2010;70(21):8959-67.
2010: Mélanie J Chagnon; Chia-Lun Wu; Takanobu Nakazawa; Tadashi Yamamoto; Masaharu Noda; Christophe Blanchetot; Michel L Tremblay
Receptor tyrosine phosphatase sigma (RPTPσ) regulates, p250GAP, a novel substrate that attenuates Rac signaling.
Cellular signalling 2010;22(11):1626-33.
2010: Kurt Dejgaard; Jean-Francois Theberge; Hannah Heath-Engel; Eric Chevet; Michel L Tremblay; David Y Thomas
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
Journal of proteome research 2010;9(4):1763-71.
2010: Odelia Katz; Matthew Stuible; Nathalia Golishevski; Lilach Lifshitz; Michel L Tremblay; Max Gassmann; Moshe Mittelman; Drorit Neumann
Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models.
The Journal of endocrinology 2010;205(1):87-95.
2010: Laurent Lessard; Matthew Stuible; Michel L Tremblay
The two faces of PTP1B in cancer.
Biochimica et biophysica acta 2010;1804(3):613-9.
2010: Elizabeth J Fry; Melanie J Chagnon; Rubèn López-Vales; Michel L Tremblay; Samuel David
Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice.
Glia 2010;58(4):423-33.
2010: Syed-Wajahat Hassan; Karen M Doody; Serge Hardy; Noriko Uetani; Denis Cournoyer; Michel L Tremblay
Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse.
PloS one 2010;5(1):e8868.
2009: Antonio Vigano; Barbara Trutschnigg; Robert D Kilgour; Nancy Hamel; L Hornby; Enriqueta Lucar; William Foulkes; Michel L Tremblay; José A Morais
Relationship between angiotensin-converting enzyme gene polymorphism and body composition, functional performance, and blood biomarkers in advanced cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2442-7.
2009: Maxime Hallé; Maria Adelaida Gomez; Matthew Stuible; Hidehisa Shimizu; W Robert McMaster; Martin Olivier; Michel L Tremblay
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation.
The Journal of biological chemistry 2009;284(11):6893-908.
2009: Karen M Doody; Annie Bourdeau; Michel L Tremblay
T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease.
Immunological reviews 2009;228(1):325-41.
2009: Jacqueline M Cohen; Jennifer A Hutcheon; Sofi G Julien; Michel L Tremblay; Rebecca Fuhrer
Insufficient milk supply and breast cancer risk: a systematic review.
PloS one 2009;4(12):e8237.
2009: Maria Adelaida Gomez; Irazu Contreras; Maxime Hallé; Michel L Tremblay; Robert W McMaster; Martin Olivier
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.
Science signaling 2009;2(90):ra58.
2009: Regina Cencic; Marilyn Carrier; Gabriela Galicia-Vázquez; Marie-Eve Bordeleau; Rami Sukarieh; Annie Bourdeau; Brigitte Brem; Jose Teodoro; Harald Greger; Michel L Tremblay; John A Porco; Jerry Pelletier
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.
PloS one 2009;4(4):e5223.
2009: Marie-Claude Gingras; Dmitri Kharitidi; Valérie Chénard; Noriko Uetani; Maxime Bouchard; Michel L Tremblay; Arnim Pause
Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP).
The International journal of developmental biology 2009;53(7):1069-74.
2009: Marie-Claude Gingras; Yu Ling Zhang; Dmitri Kharitidi; Alastair J Barr; Stefan Knapp; Michel L Tremblay; Arnim Pause
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain.
PloS one 2009;4(4):e5105.
2008: Veena Sangwan; Grigorios N Paliouras; Jasmine V Abella; Nadia Dubé; Anie Monast; Michel L Tremblay; Morag Park
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase.
The Journal of biological chemistry 2008;283(49):34374-83.
2008: Sébastien Trop; Michel L Tremblay; Annie Bourdeau
Modulation of bone marrow-derived endothelial progenitor cell activity by protein tyrosine phosphatases.
Trends in cardiovascular medicine 2008;18(5):180-6.
2008: Matthew Stuible; Nadia Dubé; Michel L Tremblay
PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446.
The Journal of biological chemistry 2008;283(23):15740-6.
2008: Matthew Stuible; Karen M Doody; Michel L Tremblay
PTP1B and TC-PTP: regulators of transformation and tumorigenesis.
Cancer metastasis reviews 2008;27(2):215-30.
2008: Michel L Tremblay; Vincent Giguère
Phosphatases at the heart of FoxO metabolic control.
Cell metabolism 2008;7(2):101-3.
2007: Maria Adelaida Gomez; Samantha Li; Michel L Tremblay; Martin Olivier
NRAMP-1 expression modulates protein-tyrosine phosphatase activity in macrophages: impact on host cell signaling and functions.
The Journal of biological chemistry 2007;282(50):36190-8.
2007: Maxime Hallé; Michel L Tremblay; Tzu-Ching Meng
Protein tyrosine phosphatases: emerging regulators of apoptosis.
Cell cycle (Georgetown, Tex.) 2007;6(22):2773-81.
2007: Annie Bourdeau; Nadia Dubé; Krista Heinonen; Jean-François Théberge; Karen M Doody; Michel L Tremblay
TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}.
Blood 2007;109(10):4220-8.
2007: Sofi G Julien; Nadia Dubé; Michelle Read; Janice Penney; Marilene Paquet; Yongxin Han; Brian P Kennedy; William J Muller; Michel L Tremblay
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.
Nature genetics 2007;39(3):338-46.
2007: Maxime Hallé; Ying-Chih Liu; Serge Hardy; Jean-François Théberge; Christophe Blanchetot; Annie Bourdeau; Tzu-Ching Meng; Michel L Tremblay
Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response.
Molecular and cellular biology 2007;27(3):1172-90.
2007: Matthew Stuible; Liang Zhao; Isabelle Aubry; Dirk Schmidt-Arras; Frank-D Böhmer; Chao-Jun Li; Michel L Tremblay
Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives.
Chembiochem : a European journal of chemical biology 2007;8(2):179-86.
2006: Jacinthe Sirois; Jean-François Côté; Amélie Charest; Noriko Uetani; Annie Bourdeau; Stephen A Duncan; Eugene Daniels; Michel L Tremblay
Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development.
Mechanisms of development 2006;123(12):869-80.
2006: Mélanie J Chagnon; Mounib Elchebly; Noriko Uetani; Luce Dombrowski; Alan Cheng; Robert A Mooney; André Marette; Michel L Tremblay
Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma.
Canadian journal of physiology and pharmacology 2006;84(7):755-63.
2006: Paul D Simoncic; C Jane McGlade; Michel L Tremblay
PTP1B and TC-PTP: novel roles in immune-cell signaling.
Canadian journal of physiology and pharmacology 2006;84(7):667-75.
2006: Paul D Simoncic; Annie Bourdeau; Ailsa Lee-Loy; Larry R Rohrschneider; Michel L Tremblay; E Richard Stanley; C Jane McGlade
T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation.
Molecular and cellular biology 2006;26(11):4149-60.
2006: Noriko Uetani; Mélanie J Chagnon; Timothy E Kennedy; Yoichiro Iwakura; Michel L Tremblay
Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(22):5872-80.
2006: Krista Heinonen; Michel L Tremblay
Protein tyrosine phosphatase 1B in hematopoiesis.
Cell cycle (Georgetown, Tex.) 2006;5(10):1053-6.
2006: Krista Heinonen; Nadia Dubé; Annie Bourdeau; Wayne S Lapp; Michel L Tremblay
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2776-81.
2006: Veena Sangwan; Grigorios N Paliouras; Alan Cheng; Nadia Dubé; Michel L Tremblay; Morag Park
Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure.
The Journal of biological chemistry 2006;281(1):221-8.
2005: Nadia Dubé; Michel L Tremblay
Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer.
Biochimica et biophysica acta 2005;1754(1-2):108-17.
2005: Jennifer S Jamieson; David A Tumbarello; Maxime Hallé; Michael C Brown; Michel L Tremblay; Christopher E Turner
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker.
Journal of cell science 2005;118(Pt 24):5835-47.
2005: Nadia Dubé; Annie Bourdeau; Krista Heinonen; Alan Cheng; Ailsa Lee Loy; Michel L Tremblay
Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development.
Cancer research 2005;65(21):10088-95.
2005: Yves R Boisclair; Michel L Tremblay
Firing up mitochondrial activities with PTPMT1.
Molecular cell 2005;19(3):291-2.
2005: Przemyslaw S Sapieha; Laure Duplan; Noriko Uetani; Sandrine Joly; Michel L Tremblay; Timothy E Kennedy; Adriana Di Polo
Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS.
Molecular and cellular neurosciences 2005;28(4):625-35.
2005: Annie Bourdeau; Nadia Dubé; Michel L Tremblay
Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP.
Current opinion in cell biology 2005;17(2):203-9.
2005: Christophe Blanchetot; M Chagnon; Nadia Dubé; Maxime Hallé; Michel L Tremblay
Substrate-trapping techniques in the identification of cellular PTP targets.
Methods (San Diego, Calif.) 2005;35(1):44-53.
2005: Christophe Blanchetot; Michel L Tremblay
Editorial.
Methods (San Diego, Calif.) 2005;35(1):1.
2004: Mélanie J Chagnon; Noriko Uetani; Michel L Tremblay
Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2004;82(6):664-75.
2004: Wei Qiu; Rita Kohen Avramoglu; Nadia Dubé; Taryne M Chong; Mark Naples; Crystal S Au; Konstantinos Gus Sidiropoulos; Gary F Lewis; Jeffrey S Cohn; Michel L Tremblay; Khosrow Adeli
Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies.
Diabetes 2004;53(12):3057-66.
2004: Feng Gu; Duc Thang Nguyên; Matthew Stuible; Nadia Dubé; Michel L Tremblay; Eric Chevet
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress.
The Journal of biological chemistry 2004;279(48):49689-93.
2004: Nadia Dubé; Michel L Tremblay
Beyond the metabolic function of PTP1B.
Cell cycle (Georgetown, Tex.) 2004;3(5):550-3.
2004: Krista Heinonen; Frederick Nestel; Evan W. Newell; Gabrielle Charette; Thomas A Seemayer; Michel L Tremblay; Wayne S Lapp
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease.
Blood 2004;103(9):3457-64.
2004: Camilla Persson; Catrine Sävenhed; Annie Bourdeau; Michel L Tremblay; Boyka Markova; Frank-D Böhmer; Fawaz G Haj; Benjamin G Neel; Ari Elson; Carl-Henrik Heldin; Lars Rönnstrand; Arne Ostman; Carina Hellberg
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
Molecular and cellular biology 2004;24(5):2190-201.
2004: Nadia Dubé; Alan Cheng; Michel L Tremblay
The role of protein tyrosine phosphatase 1B in Ras signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1834-9.
2003: Katherine M Thompson; Noriko Uetani; Colleen Manitt; Mounib Elchebly; Michel L Tremblay; Timothy E Kennedy
Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension.
Molecular and cellular neurosciences 2003;23(4):681-92.
2003: Maryse Dupuis; María De Jesús Ibarra-Sánchez; Michel L Tremblay; Pascale Duplay
Gr-1+ myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):726-32.
2003: Feng Gu; Nadia Dubé; Jin Wook Kim; Alan Cheng; Maria de Jesus Ibarra-Sanchez; Michel L Tremblay; Yves R Boisclair
Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling.
Molecular and cellular biology 2003;23(11):3753-62.
2003: Seung-Hwan Lee; Ahmed Zafer; Yves De Repentigny; Rashmi Kothary; Michel L Tremblay; Philippe Gros; Pascale Duplay; John Webb; Silvia M Vidal
Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice.
The Journal of experimental medicine 2003;197(4):515-26.
2002: Erminia Di Pietro; J Sirois; Michel L Tremblay; Robert E MacKenzie
Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development.
Molecular and cellular biology 2002;22(12):4158-66.
2002: Alan Cheng; Noriko Uetani; Paul D Simoncic; Vikas P Chaubey; Ailsa Lee-Loy; C Jane McGlade; Brian P Kennedy; Michel L Tremblay
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.
Developmental cell 2002;2(4):497-503.
2002: Paul D Simoncic; Ailsa Lee-Loy; Dwayne Barber; Michel L Tremblay; C Jane McGlade
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.
Current biology : CB 2002;12(6):446-53.
2002: Alan Cheng; Nadia Dubé; Feng Gu; Michel L Tremblay
Coordinated action of protein tyrosine phosphatases in insulin signal transduction.
European journal of biochemistry / FEBS 2002;269(4):1050-9.
2002: Jean-François Côté; Ping Lin Chung; Jean-François Théberge; Maxime Hallé; Susan Spencer; Laurence A Lasky; Michel L Tremblay
PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP.
The Journal of biological chemistry 2002;277(4):2973-86.
2001: F Levavasseur; Hiroko Miyadera; J Sirois; Michel L Tremblay; Kiyoshi Kita; Eric A Shoubridge; Siegfried Hekimi
Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration.
The Journal of biological chemistry 2001;276(49):46160-4.
2001: Kyoko Tsukiyama-Kohara; Francis Poulin; M Kohara; Christine T DeMaria; Alan Cheng; Z Wu; Anne-Claude Gingras; Asao Katsume; Mounib Elchebly; Bruce M Spiegelman; M E Harper; Michel L Tremblay; Nahum Sonenberg
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
Nature medicine 2001;7(10):1128-32.
2001: M J Ibarra-Sánchez; J Wagner; M T Ong; C Lampron; Michel L Tremblay
Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation.
Oncogene 2001;20(34):4728-39.
2001: Alan Cheng; G S Bal; Brian P Kennedy; Michel L Tremblay
Attenuation of adhesion-dependent signaling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B.
The Journal of biological chemistry 2001;276(28):25848-55.
2001: Dibyendu K Panda; Dengshun Miao; Michel L Tremblay; J Sirois; Riaz Farookhi; Geoffrey N Hendy; David Goltzman
Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7498-503.
2000: Feng Cong; S Spencer; Jean-François Côté; Yimin Wu; Michel L Tremblay; Laurence A Lasky; Stephen P Goff
Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.
Molecular cell 2000;6(6):1413-23.
2000: M J Ibarra-Sánchez; Paul D Simoncic; Frederick Nestel; Pascale Duplay; Wayne S Lapp; Michel L Tremblay
The T-cell protein tyrosine phosphatase.
Seminars in immunology 2000;12(4):379-86.
2000: Yves R Boisclair; KR Hurst; Iori Ueki; Michel L Tremblay; Guck T Ooi
Regulation and role of the acid-labile subunit of the 150-kilodalton insulin-like growth factor complex in the mouse.
Pediatric nephrology (Berlin, Germany) 2000;14(7):562-6.
2000: Iori Ueki; Guck T Ooi; Michel L Tremblay; KR Hurst; L A Bach; Yves R Boisclair
Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6868-73.
2000: Mounib Elchebly; Alan Cheng; Michel L Tremblay
Modulation of insulin signaling by protein tyrosine phosphatases.
Journal of molecular medicine (Berlin, Germany) 2000;78(9):473-82.
1999: C Wee; ES Muise; O Coquelet; M Ennis; J Wagner; N Lemieux; Philip E Branton; Alain Nepveu; Michel L Tremblay
Promoter analysis of the murine T-cell protein tyrosine phosphatase gene.
Gene 1999;237(2):351-60.
1999: Jean-François Côté; C E Turner; Michel L Tremblay
Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST.
The Journal of biological chemistry 1999;274(29):20550-60.
1999: Christian Lanctôt; A Moreau; Michel Chamberland; Michel L Tremblay; Jacques Drouin
Hindlimb patterning and mandible development require the Ptx1 gene.
Development (Cambridge, England) 1999;126(9):1805-10.
1999: Naoyuki Nishiya; Y Iwabuchi; Motoko Shibanuma; Jean-François Côté; Michel L Tremblay; Kiyoshi Nose
Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain.
The Journal of biological chemistry 1999;274(14):9847-53.
1999: Alexandre Angers-Loustau; Jean-François Côté; Amélie Charest; Donald Dowbenko; Susan Spencer; Laurence A Lasky; Michel L Tremblay
Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts.
The Journal of cell biology 1999;144(5):1019-31.
1999: Mounib Elchebly; Paul Payette; E Michaliszyn; Wanda Cromlish; S Collins; A L Loy; D Normandin; Alan Cheng; Jean Himms-Hagen; C C Chan; Chidambaram Ramachandran; Michael J Gresser; Michel L Tremblay; Brian P Kennedy
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
Science (New York, N.Y.) 1999;283(5407):1544-8.
1999: Mounib Elchebly; J Wagner; Timothy E Kennedy; Christian Lanctôt; E Michaliszyn; A Itié; Jacques Drouin; Michel L Tremblay
Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma.
Nature genetics 1999;21(3):330-3.
1999: Alexandre Angers-Loustau; Jean-François Côté; Michel L Tremblay
Roles of protein tyrosine phosphatases in cell migration and adhesion.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1999;77(6):493-505.
1998: Jean-François Côté; Amélie Charest; J Wagner; Michel L Tremblay
Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model.
Biochemistry 1998;37(38):13128-37.
1997: K E You-Ten; ES Muise; A Itié; E Michaliszyn; J Wagner; Serge Jothy; Wayne S Lapp; Michel L Tremblay
Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice.
The Journal of experimental medicine 1997;186(5):683-93.
1997: Long Nguyen; Marina Holgado-Madruga; Christiane R Maroun; Elizabeth D Fixman; Darren Kamikura; TM Fournier; Amélie Charest; Michel L Tremblay; Albert J Wong; Morag Park
Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.
The Journal of biological chemistry 1997;272(33):20811-9.
1997: Amélie Charest; J Wagner; M Kwan; Michel L Tremblay
Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2.
Oncogene 1997;14(14):1643-51.
1996: J Wagner; L A Gordon; Hong-Qiang Heng; Michel L Tremblay; Anne S Olsen
Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3.
Genomics 1996;38(1):76-8.
1996: Amélie Charest; J Wagner; S Jacob; C J McGlade; Michel L Tremblay
Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity.
The Journal of biological chemistry 1996;271(14):8424-9.
1996: E S Muise; Alice Vrielink; M A Ennis; Nicole Lemieux; Michel L Tremblay
Thermosensitive mutants of the MPTP and hPTP1B protein tyrosine phosphatases: isolation and structural analysis.
Protein science : a publication of the Protein Society 1996;5(4):604-13.
1995: S Vidal; Michel L Tremblay; Gregory Govoni; Susan Gauthier; Giovanna Sebastiani; Danielle Malo; Emil Skamene; M Olivier; Serge Jothy; Philippe Gros
The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.
The Journal of experimental medicine 1995;182(3):655-66.
1995: Amélie Charest; J Wagner; E S Muise; Hong-Qiang Heng; Michel L Tremblay
Structure of the murine MPTP-PEST gene: genomic organization and chromosomal mapping.
Genomics 1995;28(3):501-7.
1995: Amélie Charest; J Wagner; S H Shen; Michel L Tremblay
Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase.
The Biochemical journal 1995;308 ( Pt 2)():425-32.
1994: J Wagner; D Boerboom; Michel L Tremblay
Molecular cloning and tissue-specific RNA processing of a murine receptor-type protein tyrosine phosphatase.
European journal of biochemistry / FEBS 1994;226(3):773-82.
1994: U Tillmann; J Wagner; D Boerboom; Heiner Westphal; Michel L Tremblay
Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase.
Molecular and cellular biology 1994;14(5):3030-40.
1993: Paul E Love; Elizabeth W Shores; M D Johnson; Michel L Tremblay; E J Lee; Alexander Grinberg; S P Huang; Alfred Singer; Heiner Westphal
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex.
Science (New York, N.Y.) 1993;261(5123):918-21.
1992: Paul E Love; Michel L Tremblay; Heiner Westphal
Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9929-33.
1992: V L Tybulewicz; Michel L Tremblay; Mary E LaMarca; Rob Willemsen; Barbara K Stubblefield; SL Winfield; B Zablocka; Ellen Sidransky; Brian M Martin; S P Huang
Animal model of Gaucher's disease from targeted disruption of the mouse glucocerebrosidase gene.
Nature 1992;357(6377):407-10.
1992: B Mosinger; U Tillmann; Heiner Westphal; Michel L Tremblay
Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):499-503.
1989: Michel L Tremblay; D J Dumont; Philip E Branton
Analysis of phosphorylation sites in the exon 1 region of E1A proteins of human adenovirus type 5.
Virology 1989;169(2):397-407.
1989: D J Dumont; Michel L Tremblay; Philip E Branton
Phosphorylation at serine 89 induces a shift in gel mobility but has little effect on the function of adenovirus type 5 E1A proteins.
Journal of virology 1989;63(2):987-91.
1989: C J McGlade; Michel L Tremblay; Philip E Branton
Mapping of a phosphorylation site in the 176R (19 kDa) early region 1B protein of human adenovirus type 5.
Virology 1989;168(1):119-27.
1988: Michel L Tremblay; C J McGlade; G E Gerber; Philip E Branton
Identification of the phosphorylation sites in early region 1A proteins of adenovirus type 5 by amino acid sequencing of peptide fragments.
The Journal of biological chemistry 1988;263(13):6375-83.
1987: C J McGlade; Michel L Tremblay; S P Yee; R Ross; Philip E Branton
Acylation of the 176R (19-kilodalton) early region 1B protein of human adenovirus type 5.
Journal of virology 1987;61(10):3227-34.
1985: Michel L Tremblay; S P Yee; R H Persson; Silvia Bacchetti; James R Smiley; Philip E Branton
Activation and inhibition of expression of the 72,000-Da early protein of adenovirus type 5 in mouse cells constitutively expressing an immediate early protein of herpes simplex virus type 1.
Virology 1985;144(1):35-45.
1983: S P Yee; D T Rowe; Michel L Tremblay; M McDermott; Philip E Branton
Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini.
Journal of virology 1983;46(3):1003-13.