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Lori Bostrom

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James R Pruitt; Douglas G Batt; Dean A Wacker; Lori L Bostrom; Shon K Booker; Erin McLaughlin; Gregory C Houghton; Jeffrey G Varnes; David D Christ; Maryanne B Covington; Anuk M Das; Paul Davies; Danielle Graden; Ilona Kariv; Yevgeniya Orlovsky; Nicole C Stowell; Kris Vaddi; Eric A Wadman; Patricia K Welch; Swamy Yeleswaram; Kimberly A Solomon; Robert C Newton; Carl P Decicco; Percy H Carter; Soo S Ko
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
James R Pruitt; Donald J P Pinto; Robert Anthony Galemmo; Richard S Alexander; Karen A Rossi; Brian Wells; Spencer Drummond; Lori L Bostrom; Debra Burdick; Robert Bruckner; Haiying Chen; Angela Smallwood; Pancras C Wong; Matthew R Wright; Steven Bai; Joseph M Luettgen; Robert M Knabb; Patrick Y S Lam; Ruth R Wexler
Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).
John M Fevig; Donald J P Pinto; Qi Han; Mimi L Quan; James R Pruitt; Irina C Jacobson; Robert Anthony Galemmo; Shuaige Wang; Michael J Orwat; Lori L Bostrom; Robert M Knabb; Pancras C Wong; Ruth R Wexler
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.

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All Publications

2007: James R Pruitt; Douglas G Batt; Dean A Wacker; Lori L Bostrom; Shon K Booker; Erin McLaughlin; Gregory C Houghton; Jeffrey G Varnes; David D Christ; Maryanne B Covington; Anuk M Das; Paul Davies; Danielle Graden; Ilona Kariv; Yevgeniya Orlovsky; Nicole C Stowell; Kris Vaddi; Eric A Wadman; Patricia K Welch; Swamy Yeleswaram; Kimberly A Solomon; Robert C Newton; Carl P Decicco; Percy H Carter; Soo S Ko
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Bioorganic & medicinal chemistry letters 2007;17(11):2992-7.
2003: James R Pruitt; Donald J P Pinto; Robert Anthony Galemmo; Richard S Alexander; Karen A Rossi; Brian Wells; Spencer Drummond; Lori L Bostrom; Debra Burdick; Robert Bruckner; Haiying Chen; Angela Smallwood; Pancras C Wong; Matthew R Wright; Steven Bai; Joseph M Luettgen; Robert M Knabb; Patrick Y S Lam; Ruth R Wexler
Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).
Journal of medicinal chemistry 2003;46(25):5298-315.
2001: John M Fevig; Donald J P Pinto; Qi Han; Mimi L Quan; James R Pruitt; Irina C Jacobson; Robert Anthony Galemmo; Shuaige Wang; Michael J Orwat; Lori L Bostrom; Robert M Knabb; Pancras C Wong; Ruth R Wexler
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.
Bioorganic & medicinal chemistry letters 2001;11(5):641-5.
2000: James R Pruitt; Donald J P Pinto; M J Estrella; Lori L Bostrom; Robert M Knabb; Pancras C Wong; Matthew R Wright; Ruth R Wexler
Isoxazolines and isoxazoles as factor Xa inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(8):685-9.
1999: Mimi L Quan; Ann Y Liauw; Christopher D Ellis; James R Pruitt; David J Carini; Lori L Bostrom; P P Huang; K Harrison; Robert M Knabb; MJ Thoolen; Pancras C Wong; Ruth R Wexler
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.
Journal of medicinal chemistry 1999;42(15):2752-9.
1997: Chu-Biao Xue; John Wityak; Thais M Sielecki; Donald J P Pinto; Douglas G Batt; Gary A Cain; M Sworin; AL Rockwell; John Roderick; Shuaige Wang; Michael J Orwat; William E Frietze; Lori L Bostrom; J Liu; C Anne Higley; F W Rankin; AE Tobin; G Emmett; G K Lalka; J Y Sze; S V Di Meo; Shaker A Mousa; MJ Thoolen; Adrienne L Racanelli; Richard E Olson
Discovery of an orally active series of isoxazoline glycoprotein IIb/IIIa antagonists.
Journal of medicinal chemistry 1997;40(13):2064-84.
1994: S W Wright; Joseph J Petraitis; M M Abelman; Douglas G Batt; Lori L Bostrom; R L Corbett; C P Decicco; S V Di Meo; B Freimark; J V Giannaras
Heteroaryl-fused 2-phenylisothiazolone inhibitors of cartilage breakdown.
Journal of medicinal chemistry 1994;37(19):3071-8.