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David Trist

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Karen Roberts; Giovanna Tedesco; Maria Elvira Tranquillini; David G Trist; A Ursini; Robert J Barnaby; Paolo G Cassarà; Mauro Corsi; Giovanni Curotto; Daniele Donati; Aldo Feriani; G Finizia; Carla Marchioro; Daniela Niccolai; Beatrice Oliosi; S Polinelli; Emiliangelo Ratti; Angelo Reggiani; FT van Amsterdam
Synthesis and structure-activity relationship of new 1,5-dialkyl-1,5-benzodiazepines as cholecystokinin-2 receptor antagonists.
Sanjay J Mathew; Meena Vythilingam; James W Murrough; Carlos A Zarate; Adriana Feder; David Luckenbaugh; Becky Kinkead; Michael K Parides; David G Trist; Massimo S Bani; Paolo U Bettica; Emiliangelo M Ratti; Dennis S Charney
A selective neurokinin-1 receptor antagonist in chronic PTSD: a randomized, double-blind, placebo-controlled, proof-of-concept trial.
Romano Di Fabio; Giuseppe Alvaro; Cristiana Griffante; Domenica A Pizzi; Daniele Donati; Mario Mattioli; Zadeo Cimarosti; Giuseppe Guercio; Carla Marchioro; Stefano Provera; Laura Zonzini; Dino Montanari; Sergio Melotto; Philip A Gerrard; David G Trist; Emiliangelo Ratti; Mauro Corsi
Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate.

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All Publications

2011: Karen Roberts; Giovanna Tedesco; Maria Elvira Tranquillini; David G Trist; A Ursini; Robert J Barnaby; Paolo G Cassarà; Mauro Corsi; Giovanni Curotto; Daniele Donati; Aldo Feriani; G Finizia; Carla Marchioro; Daniela Niccolai; Beatrice Oliosi; S Polinelli; Emiliangelo Ratti; Angelo Reggiani; FT van Amsterdam
Synthesis and structure-activity relationship of new 1,5-dialkyl-1,5-benzodiazepines as cholecystokinin-2 receptor antagonists.
Bioorganic & medicinal chemistry 2011;19(14):4257-73.
2011: Sanjay J Mathew; Meena Vythilingam; James W Murrough; Carlos A Zarate; Adriana Feder; David Luckenbaugh; Becky Kinkead; Michael K Parides; David G Trist; Massimo S Bani; Paolo U Bettica; Emiliangelo M Ratti; Dennis S Charney
A selective neurokinin-1 receptor antagonist in chronic PTSD: a randomized, double-blind, placebo-controlled, proof-of-concept trial.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2011;21(3):221-9.
2011: Romano Di Fabio; Giuseppe Alvaro; Cristiana Griffante; Domenica A Pizzi; Daniele Donati; Mario Mattioli; Zadeo Cimarosti; Giuseppe Guercio; Carla Marchioro; Stefano Provera; Laura Zonzini; Dino Montanari; Sergio Melotto; Philip A Gerrard; David G Trist; Emiliangelo Ratti; Mauro Corsi
Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate.
Journal of medicinal chemistry 2011;54(4):1071-9.
2009: Romano Di Fabio; Cristiana Griffante; Giuseppe Alvaro; Giorgio Pentassuglia; Domenica A Pizzi; Daniele Donati; Tino Rossi; Giuseppe Guercio; Mario Mattioli; Zadeo Cimarosti; Carla Marchioro; Stefano Provera; Laura Zonzini; Dino Montanari; Sergio Melotto; Philip A Gerrard; David G Trist; Emiliangelo Ratti; Mauro Corsi
Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.
Journal of medicinal chemistry 2009;52(10):3238-47.
2003: Fabrizio Micheli; Romano Di Fabio; Paolo Cavanni; Joseph M Rimland; Anna Maria Capelli; Christian Chiamulera; Mauro Corsi; Corrado Corti; Daniele Donati; Aldo Feriani; Francesco Ferraguti; Micaela Maffeis; Andrea Missio; Emiliangelo Ratti; Alfredo Paio; Roberta Pachera; Mauro Quartaroli; Angelo Reggiani; Fabio Maria Sabbatini; David G Trist; Annarosa Ugolini; Giovanni Vitulli
Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists.
Bioorganic & medicinal chemistry 2003;11(2):171-83.
2002: Patrick M Beardsley; E Ratti; Robert L Balster; J Willetts; David G Trist
The selective glycine antagonist gavestinel lacks phencyclidine-like behavioral effects.
Behavioural pharmacology 2002;13(7):583-92.
2001: David G Trist; Mauro Corsi
Cholecystokinin (CCK) assays.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] 2001;Chapter 4():Unit 4.13.
2001: E Ratti; David G Trist
The continuing evolution of the drug discovery process in the pharmaceutical industry.
Farmaco (Società chimica italiana : 1989) 2001;56(1-2):13-9.
2000: A Ursini; Anna Maria Capelli; R A Carr; P Cassarà; Mauro Corsi; O Curcuruto; G Curotto; M Dal Cin; Silvia Davalli; Daniele Donati; Aldo Feriani; H Finch; G Finizia; Giovanni Gaviraghi; M Marien; Giorgio Pentassuglia; S Polinelli; Emiliangelo Ratti; Angelo Reggiani; Giorgio Tarzia; Giovanna Tedesco; Maria Elvira Tranquillini; David G Trist; FT van Amsterdam; A Reggiani
Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists.
Journal of medicinal chemistry 2000;43(20):3596-613.
1999: Luca Ferraro; Lorenzo Beani; David G Trist; Angelo Reggiani; Clementina Bianchi
Effects of cholecystokinin peptides and GV 150013, a selective cholecystokininB receptor antagonist, on electrically evoked endogenous GABA release from rat cortical slices.
Journal of neurochemistry 1999;73(5):1973-81.
1999: Mauro Quartaroli; C Carignani; Giovanna Dal Forno; Manolo Mugnaini; Annarosa Ugolini; Roberto Arban; Letizia Bettelini; Gabriella Maraia; F Belardetti; Angelo Reggiani; David G Trist; Emiliangelo Ratti; Romano Di Fabio; Mauro Corsi
Potent antihyperalgesic activity without tolerance produced by glycine site antagonist of N-methyl-D-aspartate receptor GV196771A.
The Journal of pharmacology and experimental therapeutics 1999;290(1):158-69.
1999: Paolo Meoni; Bernd Bunnemann; A E Kingsbury; David G Trist; Norman G Bowery
NMDA NR1 subunit mRNA and glutamate NMDA-sensitive binding are differentially affected in the striatum and pre-frontal cortex of Parkinson's disease patients.
Neuropharmacology 1999;38(5):625-33.
1999: Teresa M Seccia; Ezio Bettini; Vito Vulpis; Mauro Quartaroli; David G Trist; Giovanni Gaviraghi; Anna Pirrelli
Extracellular matrix gene expression in the left ventricular tissue of spontaneously hypertensive rats.
Blood pressure 1999;8(1):57-64.
1998: S Palea; G Toson; Claudio Pietra; David G Trist; W Artibani; O Romano; Mauro Corsi
Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder.
British journal of pharmacology 1998;124(5):865-72.
1998: Paolo Meoni; Bernd Bunnemann; David G Trist; Norman G Bowery
N-terminal splice variants of the NMDAR1 glutamate receptor subunit: differential expression in human and monkey brain.
Neuroscience letters 1998;249(1):45-8.
1998: Maria Cristina Tomasini; Tiziana Antonelli; David G Trist; Angelo Reggiani; Lorenzo Beani; Clementina Bianchi
Protective effect of GV150526A on the glutamate-induced changes in basal and electrically-stimulated cytosolic Ca++ in primary cultured cerebral cortical cells.
Neurochemistry international 1998;32(4):345-51.
1998: Paolo Meoni; Manolo Mugnaini; Bernd Bunnemann; David G Trist; Norman G Bowery
[3H]MK-801 binding and the mRNA for the NMDAR1 subunit of the NMDA receptor are differentially distributed in human and rat forebrain.
Brain research. Molecular brain research 1998;54(1):13-23.
1997: Tiziana Mennini; L Mancini; Angelo Reggiani; David G Trist
GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release.
European journal of pharmacology 1997;336(2-3):275-81.
1997: Francesco M Crespi; Mauro Corsi; T England; Emiliangelo Ratti; David G Trist; Giovanni Gaviraghi
Spontaneous preference for ethanol in naive rats is influenced by cholecystokinin A receptor antagonism.
Alcohol (Fayetteville, N.Y.) 1997;14(4):327-32.
1997: Corrado Corti; Paolo Cavanni; E Caveggion; Francesco Ferraguti; Mauro Corsi; David G Trist
Different levels of receptor expression as a new procedure to estimate agonist affinity constant. Application to the metabotropic receptors.
Annals of the New York Academy of Sciences 1997;812():231-3.
1997: Mauro Corsi; Letizia Bettelini; P Fina; David G Trist
Estimation of the relative potency of two glycine antagonists on NMDA-induced depolarizations in BRSC and ARCS.
Annals of the New York Academy of Sciences 1997;812():187-8.
1997: Romano Di Fabio; Anna Maria Capelli; Nadia Conti; A Cugola; Daniele Donati; Aldo Feriani; P Gastaldi; Giovanni Gaviraghi; C T Hewkin; Fabrizio Micheli; Andrea Missio; Manolo Mugnaini; Angelo Pecunioso; Anna M Quaglia; Emiliangelo Ratti; L Rossi; Giovanna Tedesco; David G Trist; Angelo Reggiani
Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site.
Journal of medicinal chemistry 1997;40(6):841-50.
1996: Manolo Mugnaini; FT van Amsterdam; Emiliangelo Ratti; David G Trist; Norman G Bowery
Regionally different N-methyl-D-aspartate receptors distinguished by ligand binding and quantitative autoradiography of [3H]-CGP 39653 in rat brain.
British journal of pharmacology 1996;119(5):819-28.
1996: M Corsi; P Fina; David G Trist
Co-agonism in drug-receptor interaction: illustrated by the NMDA receptors.
Trends in pharmacological sciences 1996;17(6):220-2.
1996: J M Rimland; E P Seward; Y Humbert; Emiliangelo Ratti; David G Trist; R A North
Coexpression with potassium channel subunits used to clone the Y2 receptor for neuropeptide Y.
Molecular pharmacology 1996;49(3):387-90.
1995: S Palea; Mauro Corsi; J M Rimland; David G Trist; Emiliangelo Ratti
Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens.
British journal of pharmacology 1995;116(5):2401-6.
1995: F Crespi; T G England; David G Trist
Simultaneous, selective detection of catecholaminergic and indolaminergic signals using cyclic voltammetry with treated micro-sensor.
Journal of neuroscience methods 1995;61(1-2):201-12.
1995: S Palea; Mauro Corsi; J M Rimland; David G Trist
Discrimination by benextramine between the NPY-Y1 receptor subtypes present in rabbit isolated vas deferens and saphenous vein.
British journal of pharmacology 1995;115(1):3-10.
1995: F Crespi; T England; Emiliangelo Ratti; David G Trist
Carbon fibre micro-electrodes for concomitant in vivo electrophysiological and voltammetric measurements: no reciprocal influences.
Neuroscience letters 1995;188(1):33-6.
1995: Giovanni Gaviraghi; D Micheli; David G Trist
Recent developments in the use of calcium antagonists in myocardial protection.
Pharmacological research : the official journal of the Italian Pharmacological Society 1995;31(3-4):251-4.
1995: S Palea; C Pietra; David G Trist; W Artibani; A Calpista; Mauro Corsi
Evidence for the presence of both pre- and postjunctional P2-purinoceptor subtypes in human isolated urinary bladder.
British journal of pharmacology 1995;114(1):35-40.
1994: F Crespi; Emiliangelo Ratti; David G Trist
Melatonin, a hormone monitorable in vivo by voltammetry?
The Analyst 1994;119(10):2193-7.
1994: P Cavanni; V Pinnola; Manolo Mugnaini; David G Trist; FT van Amsterdam; Francesco Ferraguti
Pharmacological analysis of carboxyphenylglycines at metabotropic glutamate receptors.
European journal of pharmacology 1994;269(1):9-15.
1994: Mauro Corsi; S Palea; C Pietra; Beatrice Oliosi; Giovanni Gaviraghi; E Sugg; FT van Amsterdam; David G Trist
A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus.
The Journal of pharmacology and experimental therapeutics 1994;270(2):734-40.
1994: Francesco Ferraguti; P Cavanni; H Eistetter; C Salvagno; Emiliangelo Ratti; David G Trist
Competitive antagonism by phenylglycine derivatives at type I metabotropic glutamate receptors.
Molecular and cellular neurosciences 1994;5(3):269-76.
1994: A Giacometti; D Micheli; Giovanni Gaviraghi; David G Trist
Quantification of the calcium antagonism of lacidipine by kinetic analysis.
The Journal of pharmacology and experimental therapeutics 1994;269(1):424-9.
1994: S Palea; Mauro Corsi; C Pietra; W Artibani; A Calpista; Giovanni Gaviraghi; David G Trist
ADP beta S induces contraction of the human isolated urinary bladder through a purinoceptor subtype different from P2X and P2Y.
The Journal of pharmacology and experimental therapeutics 1994;269(1):193-7.
1994: Mauro Corsi; G Dal Forno; Beatrice Oliosi; C Pietra; FT van Amsterdam; David G Trist
Combined dose-ratio analysis for the CCK-B antagonist virginiamycin in guinea pig ileum.
Annals of the New York Academy of Sciences 1994;713():353-4.
1993: S Palea; W Artibani; E Ostardo; David G Trist; C Pietra
Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis.
The Journal of urology 1993;150(6):2007-12.
1993: Tiziana Mennini; C Taddei; A Uslenghi; Alfredo Cagnotto; D Micheli; David G Trist; Giovanni Gaviraghi; Emiliangelo Ratti
In-vivo binding of (+)-[3H]PN 200-110 to peripheral tissues and brain of spontaneously hypertensive rats: effect of lacidipine.
The Journal of pharmacy and pharmacology 1993;45(5):430-3.
1993: S Palea; G Dalforno; Giovanni Gaviraghi; Russell Hagan; David G Trist; C Pietra
Further studies on the effects of selective neurokinin agonists upon the activation of micturition reflex in rats. Evidence for a dual NK-1 receptor mediated excitatory and inhibitory activity.
Neuropeptides 1993;24(5):285-91.
1993: Mauro Corsi; G Pojani; G Dal Forno; C Pietra; Giovanni Gaviraghi; David G Trist
Analysis of the CCKB receptor antagonism of virginiamycin in guinea-pig ileum longitudinal myenteric plexus.
British journal of pharmacology 1993;108(4):1164-8.
1992: A Giacometti; Mauro Quartaroli; Giovanni Gaviraghi; D Micheli; David G Trist
Analysis of the interaction between lacidipine and BAY K 8644 in two isolated rabbit arteries.
The Journal of pharmacology and experimental therapeutics 1992;263(3):1241-7.
1992: G Dal Forno; C Pietra; M Urciuoli; FT van Amsterdam; G Toson; Giovanni Gaviraghi; David G Trist
Evidence for two cholecystokinin receptors mediating the contraction of the guinea pig isolated ileum longitudinal muscle myenteric plexus.
The Journal of pharmacology and experimental therapeutics 1992;261(3):1056-63.
1991: Mauro Corsi; C Pietra; G Toson; David G Trist; G Tuccitto; W Artibani
Pharmacological analysis of 5-hydroxytryptamine effects on electrically stimulated human isolated urinary bladder.
British journal of pharmacology 1991;104(3):719-25.
1991: Mauro Quartaroli; F Gambini; G Tarter; D Micheli; David G Trist; Giovanni Gaviraghi
The hemodynamic effects of lacidipine in anesthetized dogs: comparison with nitrendipine, amlodipine, verapamil, and diltiazem.
Journal of cardiovascular pharmacology 1991;18(3):326-36.