John Trojanowski

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Hu William T; Seelaar Harro; Josephs Keith A; Knopman David S; Boeve Bradley F; Sorenson Eric J; McCluskey Leo; Elman Lauren; Schelhaas Helenius J; Parisi Joseph E; Kuesters Benno; Lee Virginia M-Y; Trojanowski John Q; Petersen Ronald C; van Swieten John C; Grossman Murray
Survival profiles of patients with frontotemporal dementia and motor neuron disease.
Pesiridis G Scott; Lee Virginia M-Y; Trojanowski John Q
Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.
Brunden Kurt R; Trojanowski John Q; Lee Virginia M-Y
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

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All Publications

2009: Hu William T; Seelaar Harro; Josephs Keith A; Knopman David S; Boeve Bradley F; Sorenson Eric J; McCluskey Leo; Elman Lauren; Schelhaas Helenius J; Parisi Joseph E; Kuesters Benno; Lee Virginia M-Y; Trojanowski John Q; Petersen Ronald C; van Swieten John C; Grossman Murray
Survival profiles of patients with frontotemporal dementia and motor neuron disease.
Archives of neurology 2009;66(11):1359-64.
2009: Pesiridis G Scott; Lee Virginia M-Y; Trojanowski John Q
Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.
Human molecular genetics 2009;18(R2):R156-62.
2009: Brunden Kurt R; Trojanowski John Q; Lee Virginia M-Y
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.
Nature reviews. Drug discovery 2009;8(10):783-93.
2009: Crowe Alex; Huang Wenwei; Ballatore Carlo; Johnson Ronald L; Hogan Anne-Marie L; Huang Ruili; Wichterman Jennifer; McCoy Joshua; Huryn Donna; Auld Douglas S; Smith Amos B; Inglese James; Trojanowski John Q; Austin Christopher P; Brunden Kurt R; Lee Virginia M-Y
Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening.
Biochemistry 2009;48(32):7732-45.
2009: Li Wenkai; Sperry Jeffrey B; Crowe Alex; Trojanowski John Q; Smith Amos B; Lee Virginia M-Y
Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau.
Journal of neurochemistry 2009;110(4):1339-51.
2009: Geser Felix; Martinez-Lage Maria; Kwong Linda K; Lee Virginia M-Y; Trojanowski John Q
Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases.
Journal of neurology 2009;256(8):1205-14.
2009: Vemuri P; Wiste H J; Weigand S D; Shaw L M; Trojanowski J Q; Weiner M W; Knopman D S; Petersen R C; Jack C R;
MRI and CSF biomarkers in normal, MCI, and AD subjects: predicting future clinical change.
Neurology 2009;73(4):294-301.
2009: Vemuri P; Wiste H J; Weigand S D; Shaw L M; Trojanowski J Q; Weiner M W; Knopman D S; Petersen R C; Jack C R;
MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations.
Neurology 2009;73(4):287-93.
2009: Petersen Ronald C; Trojanowski John Q
Use of Alzheimer disease biomarkers: potentially yes for clinical trials but not yet for clinical practice.
JAMA : the journal of the American Medical Association 2009;302(4):436-7.
2009: Mastroberardino Pier Giorgio; Hoffman Eric K; Horowitz Maxx P; Betarbet Ranjita; Taylor Georgia; Cheng Dongmei; Na Hye Mee; Gutekunst Claire-Anne; Gearing Marla; Trojanowski John Q; Anderson Marjorie; Chu Charleen T; Peng Junmin; Greenamyre J Timothy
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.
Neurobiology of disease 2009;34(3):417-31.
2009: Chou Yi-Yu; Leporé Natasha; Avedissian Christina; Madsen Sarah K; Parikshak Neelroop; Hua Xue; Shaw Leslie M; Trojanowski John Q; Weiner Michael W; Toga Arthur W; Thompson Paul M;
Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controls.
NeuroImage 2009;46(2):394-410.
2009: Haris Mohammad; McArdle Erin; Fenty Matthew; Singh Anup; Davatzikos Christos; Trojanowski John Q; Melhem Elias R; Clark Christopher M; Borthakur Arijitt
Early marker for Alzheimer's disease: hippocampus T1rho (T(1rho)) estimation.
Journal of magnetic resonance imaging : JMRI 2009;29(5):1008-12.
2009: Shaw Leslie M; Vanderstichele Hugo; Knapik-Czajka Malgorzata; Clark Christopher M; Aisen Paul S; Petersen Ronald C; Blennow Kaj; Soares Holly; Simon Adam; Lewczuk Piotr; Dean Robert; Siemers Eric; Potter William; Lee Virginia M-Y; Trojanowski John Q;
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.
Annals of neurology 2009;65(4):403-13.
2009: Leow Alex D; Yanovsky Igor; Parikshak Neelroop; Hua Xue; Lee Suh; Toga Arthur W; Jack Clifford R; Bernstein Matt A; Britson Paula J; Gunter Jeffrey L; Ward Chadwick P; Borowski Bret; Shaw Leslie M; Trojanowski John Q; Fleisher Adam S; Harvey Danielle; Kornak John; Schuff Norbert; Alexander Gene E; Weiner Michael W; Thompson Paul M;
Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition.
NeuroImage 2009;45(3):645-55.
2009: Schuff N; Woerner N; Boreta L; Kornfield T; Shaw L M; Trojanowski J Q; Thompson P M; Jack C R; Weiner M W;
MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers.
Brain : a journal of neurology 2009;132(Pt 4):1067-77.
2009: Chen Xiao-Han; Johnson Victoria E; Uryu Kunihiro; Trojanowski John Q; Smith Douglas H
A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injury.
Brain pathology (Zurich, Switzerland) 2009;19(2):214-23.
2009: Khachaturian Zaven S; Snyder Peter J; Doody Rachelle; Aisen Paul; Comer Meryl; Dwyer John; Frank Richard A; Holzapfel Andrew; Khachaturian Ara S; Korczyn Amos D; Roses Allen; Simpkins James W; Schneider Lon S; Albert Marilyn S; Egge Robert; Deves Aaron; Ferris Steven; Greenberg Barry D; Johnson Carl; Kukull Walter A; Poirier Judes; Schenk Dale; Thies William; Gauthier Serge; Gilman Sid; Bernick Charles; Cummings Jeffrey L; Fillit Howard; Grundman Michael; Kaye Jeff; Mucke Lennart; Reisberg Barry; Sano Mary; Pickeral Oxana; Petersen Ronald C; Mohs Richard C; Carrillo Maria; Corey-Bloom Jody P; Foster Norman L; Jacobsen Steve; Lee Virginia; Potter William Z; Sabbagh Marwan N; Salmon David; Trojanowski John Q; Wexler Nancy; Bain Lisa J
A roadmap for the prevention of dementia II: Leon Thal Symposium 2008.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009;5(2):85-92.
2009: Igaz Lionel M; Kwong Linda K; Chen-Plotkin Alice; Winton Matthew J; Unger Travis L; Xu Yan; Neumann Manuela; Trojanowski John Q; Lee Virginia M-Y
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
The Journal of biological chemistry 2009;284(13):8516-24.
2009: Geser Felix; Martinez-Lage Maria; Robinson John; Uryu Kunihiro; Neumann Manuela; Brandmeir Nicholas J; Xie Sharon X; Kwong Linda K; Elman Lauren; McCluskey Leo; Clark Chris M; Malunda Joe; Miller Bruce L; Zimmerman Earl A; Qian Jiang; Van Deerlin Vivianna; Grossman Murray; Lee Virginia M-Y; Trojanowski John Q
Clinical and pathological continuum of multisystem TDP-43 proteinopathies.
Archives of neurology 2009;66(2):180-9.
2009: Wider Christian; Dachsel Justus C; Soto Alexandra I; Heckman Michael G; Diehl Nancy N; Yue Mei; Lincoln Sarah; Aasly Jan O; Haugarvoll Kristoffer; Trojanowski John Q; Papapetropoulos Spiridon; Mash Deborah; Rajput Alex; Rajput Ali H; Gibson J Mark; Lynch Timothy; Dickson Dennis W; Uitti Ryan J; Wszolek Zbigniew K; Farrer Matthew J; Ross Owen A
FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.
Movement disorders : official journal of the Movement Disorder Society 2009;24(3):455-9.
2009: Neumann Manuela; Kwong Linda K; Lee Edward B; Kremmer Elisabeth; Flatley Andrew; Xu Yan; Forman Mark S; Troost Dirk; Kretzschmar Hans A; Trojanowski John Q; Lee Virginia M-Y
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Acta neuropathologica 2009;117(2):137-49.
2009: McCluskey Leo F; Elman Lauren B; Martinez-Lage Maria; Van Deerlin Vivianna; Yuan Wuxing; Clay Dana; Siderowf Andrew; Trojanowski John Q
Amyotrophic lateral sclerosis-plus syndrome with TAR DNA-binding protein-43 pathology.
Archives of neurology 2009;66(1):121-4.
2009: Mackenzie Ian R A; Neumann Manuela; Bigio Eileen H; Cairns Nigel J; Alafuzoff Irina; Kril Jillian; Kovacs Gabor G; Ghetti Bernardino; Halliday Glenda; Holm Ida E; Ince Paul G; Kamphorst Wouter; Revesz Tamas; Rozemuller Annemieke J M; Kumar-Singh Samir; Akiyama Haruhiko; Baborie Atik; Spina Salvatore; Dickson Dennis W; Trojanowski John Q; Mann David M A
Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations.
Acta neuropathologica 2009;117(1):15-8.
2008: Ballatore Carlo; Zhang Bin; Trojanowski John Q; Lee Virginia M-Y; Smith Amos B
In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate.
Bioorganic & medicinal chemistry letters 2008;18(23):6119-21.
2008: Ji Bin; Maeda Jun; Sawada Makoto; Ono Maiko; Okauchi Takashi; Inaji Motoki; Zhang Ming-Rong; Suzuki Kazutoshi; Ando Kiyoshi; Staufenbiel Matthias; Trojanowski John Q; Lee Virginia M Y; Higuchi Makoto; Suhara Tetsuya
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12255-67.
2008: Steinacker Petra; Hendrich Corinna; Sperfeld Anne D; Jesse Sarah; von Arnim Christine A F; Lehnert Stefan; Pabst Alice; Uttner Ingo; Tumani Hayrettin; Lee Virginia M-Y; Trojanowski John Q; Kretzschmar Hans A; Ludolph Albert; Neumann Manuela; Otto Markus
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Archives of neurology 2008;65(11):1481-7.
2008: Luk Kelvin C; Mills Ian P; Trojanowski John Q; Lee Virginia M-Y
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.
Biochemistry 2008;47(47):12614-25.
2008: Bain Lisa J; Jedrziewski Kathy; Morrison-Bogorad Marcelle; Albert Marilyn; Cotman Carl; Hendrie Hugh; Trojanowski John Q
Healthy brain aging: a meeting report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(6):443-6.
2008: Louneva Natalia; Cohen Julia W; Han Li-Ying; Talbot Konrad; Wilson Robert S; Bennett David A; Trojanowski John Q; Arnold Steven E
Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease.
The American journal of pathology 2008;173(5):1488-95.
2008: Berchtold Nicole C; Cribbs David H; Coleman Paul D; Rogers Joseph; Head Elizabeth; Kim Ronald; Beach Tom; Miller Carol; Troncoso Juan; Trojanowski John Q; Zielke H Ronald; Cotman Carl W
Gene expression changes in the course of normal brain aging are sexually dimorphic.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15605-10.
2008: Kühnlein Peter; Sperfeld Anne-Dorte; Vanmassenhove Ben; Van Deerlin Vivianna; Lee Virginia M-Y; Trojanowski John Q; Kretzschmar Hans A; Ludolph Albert C; Neumann Manuela
Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations.
Archives of neurology 2008;65(9):1185-9.
2008: Gilman S; Wenning G K; Low P A; Brooks D J; Mathias C J; Trojanowski J Q; Wood N W; Colosimo C; Dürr A; Fowler C J; Kaufmann H; Klockgether T; Lees A; Poewe W; Quinn N; Revesz T; Robertson D; Sandroni P; Seppi K; Vidailhet M
Second consensus statement on the diagnosis of multiple system atrophy.
Neurology 2008;71(9):670-6.
2008: Brunden Kurt R; Trojanowski John Q; Lee Virginia M-Y
Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments.
Journal of Alzheimer's disease : JAD 2008;14(4):393-9.
2008: Gao Hui-Ming; Kotzbauer Paul T; Uryu Kunihiro; Leight Susan; Trojanowski John Q; Lee Virginia M-Y
Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(30):7687-98.
2008: Igaz Lionel M; Kwong Linda K; Xu Yan; Truax Adam C; Uryu Kunihiro; Neumann Manuela; Clark Christopher M; Elman Lauren B; Miller Bruce L; Grossman Murray; McCluskey Leo F; Trojanowski John Q; Lee Virginia M-Y
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
The American journal of pathology 2008;173(1):182-94.
2008: Borthakur Arijitt; Sochor Matthew; Davatzikos Christos; Trojanowski John Q; Clark Christopher M
T1rho MRI of Alzheimer's disease.
NeuroImage 2008;41(4):1199-205.
2008: Uryu Kunihiro; Nakashima-Yasuda Hanae; Forman Mark S; Kwong Linda K; Clark Christopher M; Grossman Murray; Miller Bruce L; Kretzschmar Hans A; Lee Virginia M-Y; Trojanowski John Q; Neumann Manuela
Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies.
Journal of neuropathology and experimental neurology 2008;67(6):555-64.
2008: Winton Matthew J; Van Deerlin Vivianna M; Kwong Linda K; Yuan Wuxing; Wood Elisabeth McCarty; Yu Chang-En; Schellenberg Gerard D; Rademakers Rosa; Caselli Richard; Karydas Anna; Trojanowski John Q; Miller Bruce L; Lee Virginia M-Y
A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.
FEBS letters 2008;582(15):2252-6.
2008: Roy Subhojit; Winton Matthew J; Black Mark M; Trojanowski John Q; Lee Virginia M-Y
Cytoskeletal requirements in axonal transport of slow component-b.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(20):5248-56.
2008: Geser Felix; Brandmeir Nicholas J; Kwong Linda K; Martinez-Lage Maria; Elman Lauren; McCluskey Leo; Xie Sharon X; Lee Virginia M-Y; Trojanowski John Q
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Archives of neurology 2008;65(5):636-41.
2008: Trachtenberg Don I; Trojanowski John Q
Dementia: a word to be forgotten.
Archives of neurology 2008;65(5):593-5.
2008: Bian H; Van Swieten J C; Leight S; Massimo L; Wood E; Forman M; Moore P; de Koning I; Clark C M; Rosso S; Trojanowski J; Lee V M-Y; Grossman M
CSF biomarkers in frontotemporal lobar degeneration with known pathology.
Neurology 2008;70(19 Pt 2):1827-35.
2008: Grossman M; Xie S X; Libon D J; Wang X; Massimo L; Moore P; Vesely L; Berkowitz R; Chatterjee A; Coslett H B; Hurtig H I; Forman M S; Lee V M-Y; Trojanowski J Q
Longitudinal decline in autopsy-defined frontotemporal lobar degeneration.
Neurology 2008;70(22):2036-45.
2008: Van Deerlin Vivianna M; Leverenz James B; Bekris Lynn M; Bird Thomas D; Yuan Wuxing; Elman Lauren B; Clay Dana; Wood Elisabeth McCarty; Chen-Plotkin Alice S; Martinez-Lage Maria; Steinbart Ellen; McCluskey Leo; Grossman Murray; Neumann Manuela; Wu I-Lin; Yang Wei-Shiung; Kalb Robert; Galasko Douglas R; Montine Thomas J; Trojanowski John Q; Lee Virginia M-Y; Schellenberg Gerard D; Yu Chang-En
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis.
Lancet neurology 2008;7(5):409-16.
2008: Mendez Ivar; Viñuela Angel; Astradsson Arnar; Mukhida Karim; Hallett Penelope; Robertson Harold; Tierney Travis; Holness Renn; Dagher Alain; Trojanowski John Q; Isacson Ole
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years.
Nature medicine 2008;14(5):507-9.
2008: Winton Matthew J; Igaz Lionel M; Wong Margaret M; Kwong Linda K; Trojanowski John Q; Lee Virginia M-Y
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry 2008;283(19):13302-9.
2008: Chen-Plotkin Alice S; Geser Felix; Plotkin Joshua B; Clark Chris M; Kwong Linda K; Yuan Wuxing; Grossman Murray; Van Deerlin Vivianna M; Trojanowski John Q; Lee Virginia M-Y
Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.
Human molecular genetics 2008;17(10):1349-62.
2008: Leverenz James B; Hamilton Ronald; Tsuang Debby W; Schantz Aimee; Vavrek Darcy; Larson Eric B; Kukull Walter A; Lopez Oscar; Galasko Douglas; Masliah Eliezer; Kaye Jeffrey; Woltjer Randall; Clark Christopher; Trojanowski John Q; Montine Thomas J
Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient.
Brain pathology (Zurich, Switzerland) 2008;18(2):220-4.
2008: Gomes Catarina; Palma Angelina S; Almeida Rui; Regalla Manuela; McCluskey Leo F; Trojanowski John Q; Costa Júlia
Establishment of a cell model of ALS disease: Golgi apparatus disruption occurs independently from apoptosis.
Biotechnology letters 2008;30(4):603-10.
2008: Trojanowski John Q; Duff Karen; Fillit Howard; Koroshetz Walter; Kuret Jeff; Murphy Diane; Refolo Larry;
New directions for frontotemporal dementia drug discovery.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(2):89-93.
2008: Soper James H; Roy Subhojit; Stieber Anna; Lee Eliza; Wilson Robert B; Trojanowski John Q; Burd Christopher G; Lee Virginia M-Y
Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae.
Molecular biology of the cell 2008;19(3):1093-103.
2008: Lee Edward B; Lee Virginia M-Y; Trojanowski John Q; Neumann Manuela
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica 2008;115(3):305-11.
2008: Chen-Plotkin A S; Yuan W; Anderson C; McCarty Wood E; Hurtig H I; Clark C M; Miller B L; Lee V M-Y; Trojanowski J Q; Grossman M; Van Deerlin V M
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Neurology 2008;70(7):521-7.
2008: Xie S X; Forman M S; Farmer J; Moore P; Wang Y; Wang X; Clark C M; Coslett H B; Chatterjee A; Arnold S E; Rosen H; Karlawish J H T; Van Deerlin V M; Lee V M-Y; Trojanowski J Q; Grossman M
Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration.
Journal of neurology, neurosurgery, and psychiatry 2008;79(2):126-9.
2008: Trojanowski John Q; Hendricks Joan C; Jedrziewski Kathryn; Johnson F Brad; Michel Kathryn E; Hess Rebecka S; Cancro Michael P; Sleeper Meg M; Pignolo Robert; Teff Karen L; Aguirre Gustavo D; Lee Virginia M-Y; Lawler Dennis F; Pack Allan I; Davies Peter F
Exploring human/animal intersections: converging lines of evidence in comparative models of aging.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(1):1-5.
2008: Brandmeir Nicholas J; Geser Felix; Kwong Linda K; Zimmerman Earl; Qian Jiang; Lee Virginia M-Y; Trojanowski John Q
Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease.
Acta neuropathologica 2008;115(1):123-31.
2008: Geser Felix; Winton Matthew J; Kwong Linda K; Xu Yan; Xie Sharon X; Igaz Lionel M; Garruto Ralph M; Perl Daniel P; Galasko Douglas; Lee Virginia M-Y; Trojanowski John Q
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica 2008;115(1):133-45.
2008: Kwong Linda K; Uryu Kunihiro; Trojanowski John Q; Lee Virginia M-Y
TDP-43 proteinopathies: neurodegenerative protein misfolding diseases without amyloidosis.
Neuro-Signals 2008;16(1):41-51.
2008: Clark C M; Davatzikos C; Borthakur A; Newberg A; Leight S; Lee V M-Y; Trojanowski J Q
Biomarkers for early detection of Alzheimer pathology.
Neuro-Signals 2008;16(1):11-8.
2008: Trojanowski John Q
PENN neurodegenerative disease research - in the spirit of Benjamin Franklin.
Neuro-Signals 2008;16(1):5-10.
2007: Rabinovici G D; Seeley W W; Kim E J; Gorno-Tempini M L; Rascovsky K; Pagliaro T A; Allison S C; Halabi C; Kramer J H; Johnson J K; Weiner M W; Forman M S; Trojanowski J Q; Dearmond S J; Miller B L; Rosen H J
Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration.
American journal of Alzheimer's disease and other dementias 2007;22(6):474-88.
2007: Trojanowski J Q; Revesz T;
Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy.
Neuropathology and applied neurobiology 2007;33(6):615-20.
2007: Uryu Kunihiro; Chen Xiao-Han; Martinez Dan; Browne Kevin D; Johnson Victoria E; Graham David I; Lee Virginia M-Y; Trojanowski John Q; Smith Douglas H
Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans.
Experimental neurology 2007;208(2):185-92.
2007: Kim E J; Rabinovici G D; Seeley W W; Halabi C; Shu H; Weiner M W; DeArmond S J; Trojanowski J Q; Gorno-Tempini M L; Miller B L; Rosen H J
Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration.
Journal of neurology, neurosurgery, and psychiatry 2007;78(12):1375-8.
2007: Grossman Murray; Libon David J; Forman Mark S; Massimo Lauren; Wood Elisabeth; Moore Peachie; Anderson Chivon; Farmer Jennifer; Chatterjee Anjan; Clark Christopher M; Coslett H Branch; Hurtig Howard I; Lee Virginia M-Y; Trojanowski John Q
Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia.
Archives of neurology 2007;64(11):1601-9.
2007: Luk Kelvin C; Hyde Edward G; Trojanowski John Q; Lee Virginia M-Y
Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors.
Biochemistry 2007;46(44):12522-9.
2007: Forman Mark S; Trojanowski John Q; Lee Virginia M-Y
TDP-43: a novel neurodegenerative proteinopathy.
Current opinion in neurobiology 2007;17(5):548-55.
2007: Grossman Murray; Wood Elisabeth M; Moore Peachie; Neumann Manuela; Kwong Linda; Forman Mark S; Clark Christopher M; McCluskey Leo F; Miller Bruce L; Lee Virginia M-Y; Trojanowski John Q
TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Archives of neurology 2007;64(10):1449-54.
2007: Neumann Manuela; Kwong Linda K; Sampathu Deepak M; Trojanowski John Q; Lee Virginia M-Y
TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis.
Archives of neurology 2007;64(10):1388-94.
2007: Ballatore Carlo; Lee Virginia M-Y; Trojanowski John Q
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.
Nature reviews. Neuroscience 2007;8(9):663-72.
2007: Nakashima-Yasuda Hanae; Uryu Kunihiro; Robinson John; Xie Sharon X; Hurtig Howard; Duda John E; Arnold Steven E; Siderowf Andrew; Grossman Murray; Leverenz James B; Woltjer Randy; Lopez Oscar L; Hamilton Ronald; Tsuang Debby W; Galasko Douglas; Masliah Eliezer; Kaye Jeffrey; Clark Christopher M; Montine Thomas J; Lee Virginia M-Y; Trojanowski John Q
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases.
Acta neuropathologica 2007;114(3):221-9.
2007: Van Deerlin Vivianna M; Wood Elisabeth McCarty; Moore Peachie; Yuan Wuxing; Forman Mark S; Clark Christopher M; Neumann Manuela; Kwong Linda K; Trojanowski John Q; Lee Virginia M-Y; Grossman Murray
Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations.
Archives of neurology 2007;64(8):1148-53.
2007: Cairns Nigel J; Neumann Manuela; Bigio Eileen H; Holm Ida E; Troost Dirk; Hatanpaa Kimmo J; Foong Chan; White Charles L; Schneider Julie A; Kretzschmar Hans A; Carter Deborah; Taylor-Reinwald Lisa; Paulsmeyer Katherine; Strider Jeffrey; Gitcho Michael; Goate Alison M; Morris John C; Mishra Manjari; Kwong Linda K; Stieber Anna; Xu Yan; Forman Mark S; Trojanowski John Q; Lee Virginia M-Y; Mackenzie Ian R A
TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
The American journal of pathology 2007;171(1):227-40.
2007: Cairns Nigel J; Bigio Eileen H; Mackenzie Ian R A; Neumann Manuela; Lee Virginia M-Y; Hatanpaa Kimmo J; White Charles L; Schneider Julie A; Grinberg Lea Tenenholz; Halliday Glenda; Duyckaerts Charles; Lowe James S; Holm Ida E; Tolnay Markus; Okamoto Koichi; Yokoo Hideaki; Murayama Shigeo; Woulfe John; Munoz David G; Dickson Dennis W; Ince Paul G; Trojanowski John Q; Mann David M A;
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration.
Acta neuropathologica 2007;114(1):5-22.
2007: Kwong Linda K; Neumann Manuela; Sampathu Deepak M; Lee Virginia M-Y; Trojanowski John Q
TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease.
Acta neuropathologica 2007;114(1):63-70.
2007: Ballatore Carlo; Hyde Edward; Deiches Robert F; Lee Virginia M-Y; Trojanowski John Q; Huryn Donna; Smith Amos B
Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies.
Bioorganic & medicinal chemistry letters 2007;17(13):3642-6.
2007: Crowe Alex; Ballatore Carlo; Hyde Edward; Trojanowski John Q; Lee Virginia M-Y
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation.
Biochemical and biophysical research communications 2007;358(1):1-6.
2007: Mackenzie Ian R A; Bigio Eileen H; Ince Paul G; Geser Felix; Neumann Manuela; Cairns Nigel J; Kwong Linda K; Forman Mark S; Ravits John; Stewart Heather; Eisen Andrew; McClusky Leo; Kretzschmar Hans A; Monoranu Camelia M; Highley J Robin; Kirby Janine; Siddique Teepu; Shaw Pamela J; Lee Virginia M-Y; Trojanowski John Q
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology 2007;61(5):427-34.
2007: Neumann Manuela; Igaz Lionel M; Kwong Linda K; Nakashima-Yasuda Hanae; Kolb Stephen J; Dreyfuss Gideon; Kretzschmar Hans A; Trojanowski John Q; Lee Virginia M-Y
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
Acta neuropathologica 2007;113(5):543-8.
2007: Brito Catarina; Escrevente Cristina; Reis Celso A; Lee Virginia M-Y; Trojanowski John Q; Costa Júlia
Increased levels of fucosyltransferase IX and carbohydrate Lewis(x) adhesion determinant in human NT2N neurons.
Journal of neuroscience research 2007;85(6):1260-70.
2007: Jedrziewski M Kathryn; Lee Virginia M-Y; Trojanowski John Q
Physical activity and cognitive health.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2007;3(2):98-108.
2007: Murray R; Neumann M; Forman M S; Farmer J; Massimo L; Rice A; Miller B L; Johnson J K; Clark C M; Hurtig H I; Gorno-Tempini M L; Lee V M-Y; Trojanowski J Q; Grossman M
Cognitive and motor assessment in autopsy-proven corticobasal degeneration.
Neurology 2007;68(16):1274-83.
2007: Shaw Leslie M; Korecka Magdalena; Clark Christopher M; Lee Virginia M-Y; Trojanowski John Q
Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics.
Nature reviews. Drug discovery 2007;6(4):295-303.
2007: Van Deerlin Vivianna M; Forman Mark S; Farmer Jennifer M; Grossman Murray; Joyce Sonali; Crowe Alex; Trojanowski John Q; Lee Virginia M-Y; Chatterjee Anjan
Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual.
Acta neuropathologica 2007;113(4):471-9.
2007: Roy Subhojit; Winton Matthew J; Black Mark M; Trojanowski John Q; Lee Virginia M-Y
Rapid and intermittent cotransport of slow component-b proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(12):3131-8.
2007: Neumann Manuela; Kwong Linda K; Truax Adam C; Vanmassenhove Ben; Kretzschmar Hans A; Van Deerlin Vivianna M; Clark Chrisopher M; Grossman Murray; Miller Bruce L; Trojanowski John Q; Lee Virginia M-Y
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Journal of neuropathology and experimental neurology 2007;66(3):177-83.
2007: Lippa C F; Duda J E; Grossman M; Hurtig H I; Aarsland D; Boeve B F; Brooks D J; Dickson D W; Dubois B; Emre M; Fahn S; Farmer J M; Galasko D; Galvin J E; Goetz C G; Growdon J H; Gwinn-Hardy K A; Hardy J; Heutink P; Iwatsubo T; Kosaka K; Lee V M-Y; Leverenz J B; Masliah E; McKeith I G; Nussbaum R L; Olanow C W; Ravina B M; Singleton A B; Tanner C M; Trojanowski J Q; Wszolek Z K;
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers.
Neurology 2007;68(11):812-9.
2007: Forman M S; Mufson E J; Leurgans S; Pratico D; Joyce S; Leight S; Lee V M-Y; Trojanowski J Q
Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis.
Neurology 2007;68(10):757-63.
2007: Myers Amanda J; Pittman Alan M; Zhao Alice S; Rohrer Kristen; Kaleem Mona; Marlowe Lauren; Lees Andrew; Leung Doris; McKeith Ian G; Perry Robert H; Morris Chris M; Trojanowski John Q; Clark Christopher; Karlawish Jason; Arnold Steve; Forman Mark S; Van Deerlin Vivianna; de Silva Rohan; Hardy John
The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.
Neurobiology of disease 2007;25(3):561-70.
2007: Yoshiyama Yasumasa; Higuchi Makoto; Zhang Bin; Huang Shu-Ming; Iwata Nobuhisa; Saido Takaomi C; Maeda Jun; Suhara Tetsuya; Trojanowski John Q; Lee Virginia M-Y
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.
Neuron 2007;53(3):337-51.
2007: Norris Erin H; Uryu Kunihiro; Leight Susan; Giasson Benoit I; Trojanowski John Q; Lee Virginia M-Y
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.
The American journal of pathology 2007;170(2):658-66.
2006: Borthakur Arijitt; Gur Tamar; Wheaton Andrew J; Corbo Matthew; Trojanowski John Q; Lee Virginia M-Y; Reddy Ravinder
In vivo measurement of plaque burden in a mouse model of Alzheimer's disease.
Journal of magnetic resonance imaging : JMRI 2006;24(5):1011-7.
2006: Flint Beal M; Bossy-Wetzel Ella; Finkbeiner Steven; Fiskum Gary; Giasson Benoit; Johnson Carl; Khachaturian Zaven S; Lee Virginia M-Y; Nicholls David; Reddy Hemachandra; Reynolds Ian; Teplow David B; Thal Leon J; Trojanowski John Q; Walsh Dominic M; Wetzel Ronald; Wexler Nancy S; Young Anne B; Bain Lisa
Common threads in neurodegenerative disorders of aging.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(4):322-6.
2006: Clark Christopher M; Pratico Domenico; Shaw Lesley M; Leight Susan; Xie Sharon X; Gu Amy; Lee Virginia M-Y; Trojanowski John Q
Commentary on "Optimal design of clinical trials for drugs designed to slow the course of Alzheimers disease." Biochemical biomarkers of late-life dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(4):287-93.
2006: Schenk Dale; Carrillo Maria C; Trojanowski John Q
Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(4):275-81.
2006: Neumann Manuela; Sampathu Deepak M; Kwong Linda K; Truax Adam C; Micsenyi Matthew C; Chou Thomas T; Bruce Jennifer; Schuck Theresa; Grossman Murray; Clark Christopher M; McCluskey Leo F; Miller Bruce L; Masliah Eliezer; Mackenzie Ian R; Feldman Howard; Feiden Wolfgang; Kretzschmar Hans A; Trojanowski John Q; Lee Virginia M-Y
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.) 2006;314(5796):130-3.
2006: Lee Virginia M-Y; Trojanowski John Q
Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery.
Neuron 2006;52(1):33-8.
2006: Sampathu Deepak M; Neumann Manuela; Kwong Linda K; Chou Thomas T; Micsenyi Matthew; Truax Adam; Bruce Jennifer; Grossman Murray; Trojanowski John Q; Lee Virginia M-Y
Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies.
The American journal of pathology 2006;169(4):1343-52.
2006: Fan Yuxin; Limprasert Pornprot; Murray Ian V J; Smith Annette C; Lee Virginia M-Y; Trojanowski John Q; Sopher Bryce L; La Spada Albert R
Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression.
Human molecular genetics 2006;15(20):3002-11.
2006: Zhukareva Victoria; Joyce Sonali; Schuck Teresa; Van Deerlin Vivianna; Hurtig Howard; Albin Roger; Gilman Sid; Chin Steven; Miller Bruce; Trojanowski John Q; Lee Virginia M-Y
Unexpected abundance of pathological tau in progressive supranuclear palsy white matter.
Annals of neurology 2006;60(3):335-45.
2006: Goker-Alpan O; Giasson B I; Eblan M J; Nguyen J; Hurtig H I; Lee V M-Y; Trojanowski J Q; Sidransky E
Glucocerebrosidase mutations are an important risk factor for Lewy body disorders.
Neurology 2006;67(5):908-10.
2006: Liu Kangning; Solano Ingrid; Mann David; Lemere Cynthia; Mercken Marc; Trojanowski John Q; Lee Virginia M-Y
Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.
Acta neuropathologica 2006;112(2):163-74.
2006: Forman Mark S; Farmer Jennifer; Johnson Julene K; Clark Christopher M; Arnold Steven E; Coslett H Branch; Chatterjee Anjan; Hurtig Howard I; Karlawish Jason H; Rosen Howard J; Van Deerlin Vivianna; Lee Virginia M-Y; Miller Bruce L; Trojanowski John Q; Grossman Murray
Frontotemporal dementia: clinicopathological correlations.
Annals of neurology 2006;59(6):952-62.
2006: Winton Matthew J; Joyce Sonali; Zhukareva Victoria; Practico Domenico; Perl Daniel P; Galasko Douglas; Craig Ula; Trojanowski John Q; Lee Virginia M-Y
Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex.
Acta neuropathologica 2006;111(5):401-12.
2006: Liang Tsao-Wei; Truax Adam C; Trojanowski John Q; Lee Virginia M-Y; Stern Matthew B; Kotzbauer Paul T
Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation.
Movement disorders : official journal of the Movement Disorder Society 2006;21(5):718-22.
2006: Uryu Kunihiro; Richter-Landsberg Christiane; Welch William; Sun Eveline; Goldbaum Olaf; Norris Erin H; Pham Chi-Tuan; Yazawa Ikuru; Hilburger Kristen; Micsenyi Matthew; Giasson Benoit I; Bonini Nancy M; Lee Virginia M-Y; Trojanowski John Q
Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.
The American journal of pathology 2006;168(3):947-61.
2006: Giasson Benoit I; Covy Jason P; Bonini Nancy M; Hurtig Howard I; Farrer Matthew J; Trojanowski John Q; Van Deerlin Vivianna M
Biochemical and pathological characterization of Lrrk2.
Annals of neurology 2006;59(2):315-22.
2006: Lee Edward B; Leng Lewis Z; Zhang Bin; Kwong Linda; Trojanowski John Q; Abel Ted; Lee Virginia M-Y
Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.
The Journal of biological chemistry 2006;281(7):4292-9.
2006: Dabir Deepa V; Robinson Michael B; Swanson Eric; Zhang Bin; Trojanowski John Q; Lee Virginia M-Y; Forman Mark S
Impaired glutamate transport in a mouse model of tau pathology in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):644-54.
2006: Skovronsky Daniel M; Lee Virginia M-Y; Trojanowski John Q
Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications.
Annual review of pathology 2006;1():151-70.
2006: Lee Virginia M-Y; Trojanowski John Q
Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):257-62.
2005: Zhang Chen; Saatman Kathryn E; Royo Nicolas C; Soltesz Kristie M; Millard Marie; Schouten Joost W; Motta Melissa; Hoover Rachel C; McMillan Asenia; Watson Deborah J; Lee Virginia M-Y; Trojanowski John Q; McIntosh Tracy K
Delayed transplantation of human neurons following brain injury in rats: a long-term graft survival and behavior study.
Journal of neurotrauma 2005;22(12):1456-74.
2005: Trojanowski John Q; Jedrziewski M Kathryn; Asch David A
Living Longer and Paying the Price?
Science of aging knowledge environment : SAGE KE 2005;2005(49):pe38.
2005: Gilman S; May S J; Shults C W; Tanner C M; Kukull W; Lee V M-Y; Masliah E; Low P; Sandroni P; Trojanowski J Q; Ozelius L; Foroud T;
The North American Multiple System Atrophy Study Group.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(12):1687-94.
2005: McKeith I G; Dickson D W; Lowe J; Emre M; O'Brien J T; Feldman H; Cummings J; Duda J E; Lippa C; Perry E K; Aarsland D; Arai H; Ballard C G; Boeve B; Burn D J; Costa D; Del Ser T; Dubois B; Galasko D; Gauthier S; Goetz C G; Gomez-Tortosa E; Halliday G; Hansen L A; Hardy J; Iwatsubo T; Kalaria R N; Kaufer D; Kenny R A; Korczyn A; Kosaka K; Lee V M Y; Lees A; Litvan I; Londos E; Lopez O L; Minoshima S; Mizuno Y; Molina J A; Mukaetova-Ladinska E B; Pasquier F; Perry R H; Schulz J B; Trojanowski J Q; Yamada M;
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology 2005;65(12):1863-72.
2005: Nakashima Hanae; Ishihara Takeshi; Suguimoto Pilar; Yokota Osamu; Oshima Etsuko; Kugo Aki; Terada Seishi; Hamamura Takashi; Trojanowski John Q; Lee Virginia M-Y; Kuroda Shigetoshi
Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies.
Acta neuropathologica 2005;110(6):547-56.
2005: Mueller Susanne G; Weiner Michael W; Thal Leon J; Petersen Ronald C; Jack Clifford; Jagust William; Trojanowski John Q; Toga Arthur W; Beckett Laurel
The Alzheimer's disease neuroimaging initiative.
Neuroimaging clinics of North America 2005;15(4):869-77, xi-xii.
2005: Zhang Bin; Veasey Sigrid C; Wood Marcelo A; Leng Lewis Z; Kaminski Christine; Leight Susan; Abel Ted; Lee Virginia M-Y; Trojanowski John Q
Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons.
The American journal of pathology 2005;167(5):1361-9.
2005: Trojanowski John Q; Lee Virginia M-Y
Rous-Whipple Award Lecture. The Alzheimer's brain: finding out what's broken tells us how to fix it.
The American journal of pathology 2005;167(5):1183-8.
2005: Jedrziewski M Kathryn; Lee Virginia M-Y; Trojanowski John Q
Lowering the risk of Alzheimer's disease: Evidence-based practices emerge from new research.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2005;1(2):152-60.
2005: Yoshiyama Yasumasa; Uryu Kunihiro; Higuchi Makoto; Longhi Luca; Hoover Rachel; Fujimoto Scott; McIntosh Tracy; Lee Virginia M-Y; Trojanowski John Q
Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model.
Journal of neurotrauma 2005;22(10):1134-41.
2005: Higuchi Makoto; Zhang Bin; Forman Mark S; Yoshiyama Yasumasa; Trojanowski John Q; Lee Virginia M-Y
Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(41):9434-43.
2005: Yao Yuemang; Clark Christopher M; Trojanowski John Q; Lee Virginia M-Y; Praticò Domenico
Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment.
Annals of neurology 2005;58(4):623-6.
2005: Roberson E D; Hesse J H; Rose K D; Slama H; Johnson J K; Yaffe K; Forman M S; Miller C A; Trojanowski J Q; Kramer J H; Miller B L
Frontotemporal dementia progresses to death faster than Alzheimer disease.
Neurology 2005;65(5):719-25.
2005: Trojanowski John Q; Lee Virginia M-Y
Pathological tau: a loss of normal function or a gain in toxicity?
Nature neuroscience 2005;8(9):1136-7.
2005: Forman Mark S; Lee Virginia M-Y; Trojanowski John Q
Nosology of Parkinson's disease: looking for the way out of a quagmire.
Neuron 2005;47(4):479-82.
2005: Mueller Susanne G; Weiner Michael W; Thal Leon J; Petersen Ronald C; Jack Clifford R; Jagust William; Trojanowski John Q; Toga Arthur W; Beckett Laurel
Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI).
Alzheimer's & dementia : the journal of the Alzheimer's Association 2005;1(1):55-66.
2005: Norris Erin H; Giasson Benoit I; Hodara Roberto; Xu Shaohua; Trojanowski John Q; Ischiropoulos Harry; Lee Virginia M-Y
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.
The Journal of biological chemistry 2005;280(22):21212-9.
2005: Trojanowski John Q; Smith Amos B; Huryn Donna; Lee Virginia M-Y
Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments.
Expert opinion on pharmacotherapy 2005;6(5):683-6.
2005: Mishizen-Eberz Amanda J; Norris Erin H; Giasson Benoit I; Hodara Roberto; Ischiropoulos Harry; Lee Virginia M-Y; Trojanowski John Q; Lynch David R
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
Biochemistry 2005;44(21):7818-29.
2005: Mott Ryan T; Dickson Dennis W; Trojanowski John Q; Zhukareva Vicki; Lee Virginia M; Forman Mark; Van Deerlin Vivianna; Ervin John F; Wang Deng-Shun; Schmechel Donald E; Hulette Christine M
Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias.
Journal of neuropathology and experimental neurology 2005;64(5):420-8.
2005: Roy Subhojit; Chu Albert; Trojanowski John Q; Zhang Paul J
D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas.
Acta neuropathologica 2005;109(5):497-502.
2005: Lee Edward B; Leng Lewis Z; Lee Virginia M-Y; Trojanowski John Q
Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis.
FEBS letters 2005;579(12):2564-8.
2005: Grossman Murray; Farmer Jennifer; Leight Susan; Work Melissa; Moore Peachie; Van Deerlin Vivianna; Pratico Domenico; Clark Christopher M; Coslett H Branch; Chatterjee Anjan; Gee James; Trojanowski John Q; Lee Virginia M-Y
Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease.
Annals of neurology 2005;57(5):721-9.
2005: Trojanowski John Q; Jedrziewski M Kathryn; Johnson Brad; Whitaker Linton A
The art and science of anti-aging therapies.
Science of aging knowledge environment : SAGE KE 2005;2005(17):pe11.
2005: Forman Mark S; Lal Devika; Zhang Bin; Dabir Deepa V; Swanson Eric; Lee Virginia M-Y; Trojanowski John Q
Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(14):3539-50.
2005: Bodner Sara M; Berrettini Wade; van Deerlin Vivianna; Bennett David A; Wilson Robert S; Trojanowski John Q; Arnold Steven E
Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;134B(1):1-5.
2005: Yazawa Ikuru; Giasson Benoit I; Sasaki Ryogen; Zhang Bin; Joyce Sonali; Uryu Kunihiro; Trojanowski John Q; Lee Virginia M-Y
Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration.
Neuron 2005;45(6):847-59.
2005: Geerts Hugo; Trojanowski John Q; Lee Virginia M-Y
Drug discovery in neurodegenerative diseases.
Science of aging knowledge environment : SAGE KE 2005;2005(6):pe4.
2005: Liang T-W; Forman M S; Duda J E; McCluskey L; Trojanowski J Q; Siderowf A
Multiple pathologies in a patient with a progressive neurodegenerative syndrome.
Journal of neurology, neurosurgery, and psychiatry 2005;76(2):252-5.
2005: Kotzbauer Paul T; Truax Adam C; Trojanowski John Q; Lee Virginia M-Y
Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(3):689-98.
2005: Roy Subhojit; Zhang Bin; Lee Virginia M-Y; Trojanowski John Q
Axonal transport defects: a common theme in neurodegenerative diseases.
Acta neuropathologica 2005;109(1):5-13.
2005: Lee Edward B; Zhang Bin; Liu Kangning; Greenbaum Eric A; Doms Robert W; Trojanowski John Q; Lee Virginia M-Y
BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo.
The Journal of cell biology 2005;168(2):291-302.
2005: Zhang Bin; Maiti Arpita; Shively Sharon; Lakhani Fara; McDonald-Jones Gaye; Bruce Jennifer; Lee Edward B; Xie Sharon X; Joyce Sonali; Li Chi; Toleikis Philip M; Lee Virginia M-Y; Trojanowski John Q
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):227-31.
2005: Lee Virginia M-Y; Kenyon Theresa K; Trojanowski John Q
Transgenic animal models of tauopathies.
Biochimica et biophysica acta 2005;1739(2-3):251-9.
2004: Longhi Luca; Watson Deborah J; Saatman Kathryn E; Thompson Hilaire J; Zhang Chen; Fujimoto Scott; Royo Nicolas; Castelbuono Deborah; Raghupathi Ramesh; Trojanowski John Q; Lee Virginia M-Y; Wolfe John H; Stocchetti Nino; McIntosh Tracy K
Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice.
Journal of neurotrauma 2004;21(12):1723-36.
2004: Popescu Anca; Lippa Carol F; Lee Virginia M-Y; Trojanowski John Q
Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions.
Archives of neurology 2004;61(12):1915-9.
2004: Sung Syaun; Yang Hengxuan; Uryu Kunihiro; Lee Edward B; Zhao Lei; Shineman Diana; Trojanowski John Q; Lee Virginia M-Y; Praticò Domenico
Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease.
The American journal of pathology 2004;165(6):2197-206.
2004: Schouten Joost W; Fulp Carl T; Royo Nicolas C; Saatman Kathryn E; Watson Deborah J; Snyder Evan Y; Trojanowski John Q; Prockop Darwin J; Maas Andrew I R; McIntosh Tracy K
A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury.
Journal of neurotrauma 2004;21(11):1501-38.
2004: Cairns Nigel J; Lee Virginia M-Y; Trojanowski John Q
The cytoskeleton in neurodegenerative diseases.
The Journal of pathology 2004;204(4):438-49.
2004: Ikonomovic Milos D; Uryu Kunihiro; Abrahamson Eric E; Ciallella John R; Trojanowski John Q; Lee Virginia M-Y; Clark Robert S; Marion Donald W; Wisniewski Stephen R; DeKosky Steven T
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury.
Experimental neurology 2004;190(1):192-203.
2004: Cairns N J; Grossman M; Arnold S E; Burn D J; Jaros E; Perry R H; Duyckaerts C; Stankoff B; Pillon B; Skullerud K; Cruz-Sanchez F F; Bigio E H; Mackenzie I R A; Gearing M; Juncos J L; Glass J D; Yokoo H; Nakazato Y; Mosaheb S; Thorpe J R; Uryu K; Lee V M-Y; Trojanowski J Q
Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease.
Neurology 2004;63(8):1376-84.
2004: Forman Mark S; Trojanowski John Q; Lee Virginia M-Y
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs.
Nature medicine 2004;10(10):1055-63.
2004: Ohtake H; Limprasert P; Fan Y; Onodera O; Kakita A; Takahashi H; Bonner L T; Tsuang D W; Murray I V J; Lee V M-Y; Trojanowski J Q; Ishikawa A; Idezuka J; Murata M; Toda T; Bird T D; Leverenz J B; Tsuji S; La Spada A R
Beta-synuclein gene alterations in dementia with Lewy bodies.
Neurology 2004;63(5):805-11.
2004: Cairns Nigel J; Uryu Kunihiro; Bigio Eileen H; Mackenzie Ian R A; Gearing Marla; Duyckaerts Charles; Yokoo Hideaki; Nakazato Yoichi; Jaros Evelyn; Perry Robert H; Arnold Steven E; Lee Virginia M-Y; Trojanowski John Q
alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases.
Acta neuropathologica 2004;108(3):213-23.
2004: Chen Xiao-Han; Siman Robert; Iwata Akira; Meaney David F; Trojanowski John Q; Smith Douglas H
Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma.
The American journal of pathology 2004;165(2):357-71.
2004: Conte Valeria; Uryu Kunihiro; Fujimoto Scott; Yao Yuemang; Rokach Joshua; Longhi Luca; Trojanowski John Q; Lee Virginia M-Y; McIntosh Tracy K; Praticò Domenico
Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury.
Journal of neurochemistry 2004;90(3):758-64.
2004: Nakashima Hanae; Ishihara Takeshi; Yokota Osamu; Terada Seishi; Trojanowski John Q; Lee Virginia M-Y; Kuroda Shigetoshi
Effects of alpha-tocopherol on an animal model of tauopathies.
Free radical biology & medicine 2004;37(2):176-86.
2004: Chen Zhijian J; Vulevic Bojana; Ile Kristina E; Soulika Athena; Davis Warren; Reiner Peter B; Connop Bruce P; Nathwani Parimal; Trojanowski John Q; Tew Kenneth D
Association of ABCA2 expression with determinants of Alzheimer's disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(10):1129-31.
2004: Ginsberg Stephen D; Elarova Irina; Ruben Marc; Tan Fengzhu; Counts Scott E; Eberwine James H; Trojanowski John Q; Hemby Scott E; Mufson Elliott J; Che Shaoli
Single-cell gene expression analysis: implications for neurodegenerative and neuropsychiatric disorders.
Neurochemical research 2004;29(6):1053-64.
2004: Cairns Nigel J; Zhukareva Victoria; Uryu Kunihiro; Zhang Bin; Bigio Eileen; Mackenzie Ian R A; Gearing Marla; Duyckaerts Charles; Yokoo Hideaki; Nakazato Yoichi; Jaros Evelyn; Perry Robert H; Lee Virginia M-Y; Trojanowski John Q
alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease.
The American journal of pathology 2004;164(6):2153-61.
2004: Kotzbauer Paul T; Giasson Benoit I; Kravitz Alexxai V; Golbe Lawrence I; Mark Margery H; Trojanowski John Q; Lee Virginia M-Y
Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.
Experimental neurology 2004;187(2):279-88.
2004: Zhang Bin; Higuchi Makoto; Yoshiyama Yasumasa; Ishihara Takeshi; Forman Mark S; Martinez Dan; Joyce Sonali; Trojanowski John Q; Lee Virginia M-Y
Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(19):4657-67.
2004: Talbot Konrad; Eidem Wess L; Tinsley Caroline L; Benson Matthew A; Thompson Edward W; Smith Rachel J; Hahn Chang-Gyu; Siegel Steven J; Trojanowski John Q; Gur Raquel E; Blake Derek J; Arnold Steven E
Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia.
The Journal of clinical investigation 2004;113(9):1353-63.
2004: Wilson Christina A; Murphy Diane D; Giasson Benoit I; Zhang Bin; Trojanowski John Q; Lee Virginia M-Y
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons.
The Journal of cell biology 2004;165(3):335-46.
2004: Praticò Domenico; Zhukareva Victoria; Yao Yuemang; Uryu Kunihiro; Funk Colin D; Lawson John A; Trojanowski John Q; Lee Virginia M-Y
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.
The American journal of pathology 2004;164(5):1655-62.
2004: Macknin Jonathan B; Higuchi Makoto; Lee Virginia M-Y; Trojanowski John Q; Doty Richard L
Olfactory dysfunction occurs in transgenic mice overexpressing human tau protein.
Brain research 2004;1000(1-2):174-8.
2004: Lee Virginia M-Y; Giasson Benoit I; Trojanowski John Q
More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases.
Trends in neurosciences 2004;27(3):129-34.
2004: Chou Kelvin L; Forman Mark S; Trojanowski John Q; Hurtig Howard I; Baltuch Gordon H
Subthalamic nucleus deep brain stimulation in a patient with levodopa-responsive multiple system atrophy. Case report.
Journal of neurosurgery 2004;100(3):553-6.
2004: Wilhelmsen Kirk C; Forman Mark S; Rosen Howard J; Alving Loren I; Goldman Jill; Feiger Jennie; Lee James V; Segall Samantha K; Kramer Joel H; Lomen-Hoerth Catherine; Rankin Katherine P; Johnson Julene; Feiler Heidi S; Weiner Michael W; Lee Virginia M-Y; Trojanowski John Q; Miller Bruce L
17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions.
Archives of neurology 2004;61(3):398-406.
2004: Zhukareva Victoria; Trojanowski John Q; Lee Virginia M-Y
Assessment of pathological tau proteins in frontotemporal dementias: qualitative and quantitative approaches.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2004;12(2):136-45.
2004: Trojanowski John Q
Protein mis-folding emerges as a "drugable" target for discovery of novel therapies for neuropsychiatric diseases of aging.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2004;12(2):134-5.
2004: Pickering-Brown Stuart; Baker Matt; Bird Thomas; Trojanowski John; Lee Virginia; Morris Huw; Rossor Martin; Janssen John C; Neary David; Craufurd David; Richardson Anna; Snowden Julie; Hardy John; Mann David; Hutton Mike
Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;125B(1):79-82.
2004: Sung Syuan; Yao Yuemang; Uryu Kunihiro; Yang Hengxuan; Lee Virginia M-Y; Trojanowski John Q; Praticò Domenico
Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):323-5.
2004: Rizzu Patrizia; Hinkle David A; Zhukareva Victoria; Bonifati Vincenzo; Severijnen Lies-Anne; Martinez Daniel; Ravid Rivka; Kamphorst Wouter; Eberwine James H; Lee Virginia M-Y; Trojanowski John Q; Heutink Peter
DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
Annals of neurology 2004;55(1):113-8.
2004: Dabir Deepa V; Trojanowski John Q; Richter-Landsberg Christiane; Lee Virginia M-Y; Forman Mark S
Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology.
The American journal of pathology 2004;164(1):155-66.
2003: Clark Christopher M; Xie Sharon; Chittams Jesse; Ewbank Douglas; Peskind Elaine; Galasko Douglas; Morris John C; McKeel Daniel W; Farlow Martin; Weitlauf Sharon L; Quinn Joseph; Kaye Jeffrey; Knopman David; Arai Hiroyuki; Doody Rachelle S; DeCarli Charles; Leight Susan; Lee Virginia M-Y; Trojanowski John Q
Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
Archives of neurology 2003;60(12):1696-702.
2003: Kung Hang F; Kung Mei Ping; Zhuang Zhi Ping; Hou Catherine; Lee Chi-Wan; Plössl Karl; Zhuang Bing; Skovronsky Daniel M; Lee Virginia M-Y; Trojanowski John Q
Iodinated tracers for imaging amyloid plaques in the brain.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2003;5(6):418-26.
2003: Söderberg Linda; Zhukareva Victoria; Bogdanovic Nenad; Hashimoto Tadafumi; Winblad Bengt; Iwatsubo Takeshi; Lee Virginia M Y; Trojanowski John Q; Näslund Jan
Molecular identification of AMY, an Alzheimer disease amyloid-associated protein.
Journal of neuropathology and experimental neurology 2003;62(11):1108-17.
2003: Uryu K; Giasson B I; Longhi L; Martinez D; Murray I; Conte V; Nakamura M; Saatman K; Talbot K; Horiguchi T; McIntosh T; Lee V M-Y; Trojanowski J Q
Age-dependent synuclein pathology following traumatic brain injury in mice.
Experimental neurology 2003;184(1):214-24.
2003: Yoshiyama Yasumasa; Zhang Bin; Bruce Jennifer; Trojanowski John Q; Lee Virginia M-Y
Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(33):10662-71.
2003: Nicholl David J; Greenstone Michael A; Clarke Carl E; Rizzu Patrizia; Crooks Daniel; Crowe Alex; Trojanowski John Q; Lee Virginia M-Y; Heutink Peter
An English kindred with a novel recessive tauopathy and respiratory failure.
Annals of neurology 2003;54(5):682-6.
2003: Pawlyk Aaron C; Giasson Benoit I; Sampathu Deepak M; Perez Francisco A; Lim Kah Leong; Dawson Valina L; Dawson Ted M; Palmiter Richard D; Trojanowski John Q; Lee Virginia M-Y
Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.
The Journal of biological chemistry 2003;278(48):48120-8.
2003: Lee Virginia M-Y; Trojanowski John Q
Research on the brain.
Science of aging knowledge environment : SAGE KE 2003;2003(42):pe29.
2003: Goldbaum Olaf; Oppermann Malte; Handschuh Melanie; Dabir Deepa; Zhang Bin; Forman Mark S; Trojanowski John Q; Lee Virginia M-Y; Richter-Landsberg Christiane
Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(26):8872-80.
2003: Falke Eric; Nissanov Jonathan; Mitchell Thomas W; Bennett David A; Trojanowski John Q; Arnold Steven E
Subicular dendritic arborization in Alzheimer's disease correlates with neurofibrillary tangle density.
The American journal of pathology 2003;163(4):1615-21.
2003: Van Deerlin Vivianna M; Gill Lisa H; Farmer Jennifer M; Trojanowski John Q; Lee Virginia M-Y
Familial frontotemporal dementia: from gene discovery to clinical molecular diagnostics.
Clinical chemistry 2003;49(10):1717-25.
2003: Counelis George J; Simuni Tanya; Forman Mark S; Jaggi Jurg L; Trojanowski John Q; Baltuch Gordon H
Bilateral subthalamic nucleus deep brain stimulation for advanced PD: correlation of intraoperative MER and postoperative MRI with neuropathological findings.
Movement disorders : official journal of the Movement Disorder Society 2003;18(9):1062-5.
2003: Crystal Adam S; Giasson Benoit I; Crowe Alexander; Kung Mei-Ping; Zhuang Zhi-Ping; Trojanowski John Q; Lee Virginia M-Y
A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114.
Journal of neurochemistry 2003;86(6):1359-68.
2003: Horiguchi Takashi; Uryu Kunihiro; Giasson Benoit I; Ischiropoulos Harry; LightFoot Richard; Bellmann Christine; Richter-Landsberg Christiane; Lee Virginia M-Y; Trojanowski John Q
Nitration of tau protein is linked to neurodegeneration in tauopathies.
The American journal of pathology 2003;163(3):1021-31.
2003: Giasson Benoit I; Mabon Meghann E; Duda John E; Montine Thomas J; Robertson David; Hurtig Howard I; Lee Virginia M-Y; Trojanowski John Q
Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy.
Acta neuropathologica 2003;106(3):243-50.
2003: Yao Y; Zhukareva V; Sung S; Clark C M; Rokach J; Lee V M-Y; Trojanowski J Q; Praticò D
Enhanced brain levels of 8,12-iso-iPF2alpha-VI differentiate AD from frontotemporal dementia.
Neurology 2003;61(4):475-8.
2003: Trojanowski John Q; Lee Virginia M-Y
Meeting summary--cell biology of Parkinson's disease and related neurodegenerative disorders.
Science of aging knowledge environment : SAGE KE 2003;2003(32):PE23.
2003: Forman Mark S; Lee Virginia M-Y; Trojanowski John Q
'Unfolding' pathways in neurodegenerative disease.
Trends in neurosciences 2003;26(8):407-10.
2003: Mishizen-Eberz Amanda J; Guttmann Rodney P; Giasson Benoit I; Day George A; Hodara Roberto; Ischiropoulos Harry; Lee Virginia M-Y; Trojanowski John Q; Lynch David R
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro.
Journal of neurochemistry 2003;86(4):836-47.
2003: Kraemer Brian C; Zhang Bin; Leverenz James B; Thomas James H; Trojanowski John Q; Schellenberg Gerard D
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9980-5.
2003: Fung Kar-Ming; Rorke Lucy B; Giasson Benoit; Lee Virginia M-Y; Trojanowski John Q
Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas.
Acta neuropathologica 2003;106(2):167-75.
2003: Murray Ian V J; Giasson Benoit I; Quinn Shawn M; Koppaka Vishwanath; Axelsen Paul H; Ischiropoulos Harry; Trojanowski John Q; Lee Virginia M-Y
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.
Biochemistry 2003;42(28):8530-40.
2003: Sampathu Deepak M; Giasson Benoit I; Pawlyk Aaron C; Trojanowski John Q; Lee Virginia M-Y
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.
The American journal of pathology 2003;163(1):91-100.
2003: Frank Richard A; Galasko Douglas; Hampel Harald; Hardy John; de Leon Mony J; Mehta Pankaj D; Rogers Joseph; Siemers Eric; Trojanowski John Q;
Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease.
Neurobiology of aging 2003;24(4):521-36.
2003: Trojanowski John Q; Lee Virginia M-Y
Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses.
Annals of the New York Academy of Sciences 2003;991():107-10.
2003: Dentchev Tzvete; Milam Ann H; Lee Virginia M-Y; Trojanowski John Q; Dunaief Joshua L
Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas.
Molecular vision 2003;9():184-90.
2003: Zhukareva Victoria; Sundarraj Sonali; Mann David; Sjogren Magnus; Blenow Kaj; Clark Christopher M; McKeel Daniel W; Goate Alison; Lippa Carol F; Vonsattel Jean-Paul; Growdon John H; Trojanowski John Q; Lee Virginia M-Y
Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study.
Acta neuropathologica 2003;105(5):469-76.
2003: Watson Deborah J; Longhi Luca; Lee Edward B; Fulp Carl T; Fujimoto Scott; Royo Nicolas C; Passini Marco A; Trojanowski John Q; Lee Virginia M Y; McIntosh Tracy K; Wolfe John H
Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury.
Journal of neuropathology and experimental neurology 2003;62(4):368-80.
2003: Giasson Benoit I; Forman Mark S; Higuchi Makoto; Golbe Lawrence I; Graves Charles L; Kotzbauer Paul T; Trojanowski John Q; Lee Virginia M-Y
Initiation and synergistic fibrillization of tau and alpha-synuclein.
Science (New York, N.Y.) 2003;300(5619):636-40.
2003: Kung Mei-Ping; Skovronsky Daniel M; Hou Catherine; Zhuang Zhi-Ping; Gur Tamar L; Zhang Bin; Trojanowski John Q; Lee Virginia M-Y; Kung Hank F
Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients.
Journal of molecular neuroscience : MN 2003;20(1):15-24.
2003: Murray Ian J; Medford Marlon A; Guan Hong-Ping; Rueter Susan M; Trojanowski John Q; Lee Virginia M-Y
Synphilin in normal human brains and in synucleinopathies: studies with new antibodies.
Acta neuropathologica 2003;105(2):177-84.
2003: Hemby Scott E; Trojanowski John Q; Ginsberg Stephen D
Neuron-specific age-related decreases in dopamine receptor subtype mRNAs.
The Journal of comparative neurology 2003;456(2):176-83.
2003: Saito Takashi; Takaki Yoshie; Iwata Nobuhisa; Trojanowski John; Saido Takaomi C
Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism.
Science of aging knowledge environment : SAGE KE 2003;2003(3):PE1.
2003: Trojanowski John Q
Rotenone neurotoxicity: a new window on environmental causes of Parkinson's disease and related brain amyloidoses.
Experimental neurology 2003;179(1):6-8.
2003: Smith Douglas H; Uryu Kunihiro; Saatman Kathryn E; Trojanowski John Q; McIntosh Tracy K
Protein accumulation in traumatic brain injury.
Neuromolecular medicine 2003;4(1-2):59-72.
2003: Giasson Benoit I; Lee Virginia M-Y; Trojanowski John Q
Interactions of amyloidogenic proteins.
Neuromolecular medicine 2003;4(1-2):49-58.
2003: Trojanowski John Q; Mattson Mark P
Overview of protein aggregation in single, double, and triple neurodegenerative brain amyloidoses.
Neuromolecular medicine 2003;4(1-2):1-6.
2002: Heuer Gregory G; Passini Marco A; Jiang Kanli; Parente Michael K; Lee Virginia M-Y; Trojanowski John Q; Wolfe John H
Selective neurodegeneration in murine mucopolysaccharidosis VII is progressive and reversible.
Annals of neurology 2002;52(6):762-70.
2002: Hasegawa Masato; Fujiwara Hideo; Nonaka Takashi; Wakabayashi Koichi; Takahashi Hitoshi; Lee Virginia M-Y; Trojanowski John Q; Mann David; Iwatsubo Takeshi
Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.
The Journal of biological chemistry 2002;277(50):49071-6.
2002: Trojanowski John Q
"Emerging Alzheimer's disease therapies: focusing on the future".
Neurobiology of aging 2002;23(6):985-90.
2002: Kung Mei-Ping; Hou Catherine; Zhuang Zhi-Ping; Zhang Bin; Skovronsky Daniel; Trojanowski John Q; Lee Virginia M-Y; Kung Hank F
IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques.
Brain research 2002;956(2):202-10.
2002: Neumann Manuela; Kahle Philipp J; Giasson Benoit I; Ozmen Laurence; Borroni Edilio; Spooren Will; Müller Veronika; Odoy Sabine; Fujiwara Hideo; Hasegawa Masato; Iwatsubo Takeshi; Trojanowski John Q; Kretzschmar Hans A; Haass Christian
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
The Journal of clinical investigation 2002;110(10):1429-39.
2002: Achim Cristian; Auer Roland; Bergeron Catherine; Cardozo Adriana; Deprez Manuel; de Vos Rob; Duyckaerts Charles; Egensperger Rupert; Esiri Margaret; Frosch Matthew P; Giannini Caterina; Goebel Hans H; Graeber Manuel B; Graham David I; Gray Francoise; Haltia Matti; Hashizume Yoshio; Ikeda Kenji; Ironside James W; Kreutzberg Georg W; Lantos Peter; Lowe James; Ludwin Samuel; Matsumoto Yoh; Olsson Yngve; Sasaki Atsushi; Scheithauer Bernd W; Takahashi Hitoshi; Tolnay Markus; Trojanowski John Q; Troost Dirk; de F Webster Henry
Global democratic consensus on neuropathological disease criteria.
Lancet neurology 2002;1(6):340.
2002: Trojanowski John Q; Lee Virginia M Y
Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses.
Neurotoxicology 2002;23(4-5):457-60.
2002: Zhukareva Victoria; Shah Keyur; Uryu Kunihiro; Braak Heiko; Del Tredici Kelly; Sundarraj Sonali; Clark Christopher; Trojanowski John Q; Lee Virginia M-Y
Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study.
The American journal of pathology 2002;161(4):1135-41.
2002: Poorkaj Parvoneh; Muma Nancy A; Zhukareva Victoria; Cochran Elizabeth J; Shannon Kathleen M; Hurtig Howard; Koller William C; Bird Thomas D; Trojanowski John Q; Lee Virginia M-Y; Schellenberg Gerard D
An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype.
Annals of neurology 2002;52(4):511-6.
2002: Trojanowski John Q
Tauists, Baptists, Syners, Apostates, and new data.
Annals of neurology 2002;52(3):263-5.
2002: Kung Mei-Ping; Hou Catherine; Zhuang Zhi-Ping; Skovronsky Daniel M; Zhang Bin; Gur Tamar L; Trojanowski John Q; Lee Virginia M Y; Kung Hank F
Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in Alzheimer's disease.
Journal of molecular neuroscience : MN 2002;19(1-2):7-10.
2002: Duda John E; Giasson Benoit I; Mabon Meghann E; Lee Virginia M-Y; Trojanowski John Q
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.
Annals of neurology 2002;52(2):205-10.
2002: Morris H R; Baker M; Yasojima K; Houlden H; Khan M N; Wood N W; Hardy J; Grossman M; Trojanowski J; Revesz T; Bigio E H; Bergeron C; Janssen J C; McGeer P L; Rossor M N; Lees A J; Lantos P L; Hutton M
Analysis of tau haplotypes in Pick's disease.
Neurology 2002;59(3):443-5.
2002: Higuchi Makoto; Ishihara Takeshi; Zhang Bin; Hong Ming; Andreadis Athena; Trojanowski John; Lee Virginia M-Y
Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration.
Neuron 2002;35(3):433-46.
2002: Trojanowski John Q; Ishihara Takeshi; Higuchi Makoto; Yoshiyama Yasumasa; Hong Ming; Zhang Bin; Forman Mark S; Zhukareva Victoria; Lee Virginia M-Y
Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam.
Experimental neurology 2002;176(1):1-11.
2002: Hemby Scott E; Ginsberg Stephen D; Brunk Brian; Arnold Steven E; Trojanowski John Q; Eberwine James H
Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex.
Archives of general psychiatry 2002;59(7):631-40.
2002: Duda John E; Giasson Benoit I; Mabon Meghann E; Miller Douglas C; Golbe Lawrence I; Lee Virginia M-Y; Trojanowski John Q
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
Acta neuropathologica 2002;104(1):7-11.
2002: Praticò Domenico; Uryu Kunihiro; Sung Syan; Tang Sei; Trojanowski John Q; Lee Virginia M-Y
Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1138-40.
2002: Zhukareva Victoria; Mann David; Pickering-Brown Stuart; Uryu Kunihiro; Shuck Theresa; Shah Keyur; Grossman Murray; Miller Bruce L; Hulette Christine M; Feinstein Stuart C; Trojanowski John Q; Lee Virginia M-Y
Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter.
Annals of neurology 2002;51(6):730-9.
2002: Forman Mark S; Zhukareva Victoria; Bergeron Catherine; Chin Steven S-M; Grossman Murray; Clark Chris; Lee Virginia M-Y; Trojanowski John Q
Signature tau neuropathology in gray and white matter of corticobasal degeneration.
The American journal of pathology 2002;160(6):2045-53.
2002: Giasson Benoit I; Ischiropoulos Harry; Lee Virginia M-Y; Trojanowski John Q
The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases.
Free radical biology & medicine 2002;32(12):1264-75.
2002: Praticò Domenico; Clark Christopher M; Liun Feyan; Rokach Joshua; Lee Virginia Y-M; Trojanowski John Q
Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.
Archives of neurology 2002;59(6):972-6.
2002: Trojanowski John Q; Lee Virginia M Y
The role of tau in Alzheimer's disease.
The Medical clinics of North America 2002;86(3):615-27.
2002: Giasson Benoit I; Duda John E; Quinn Shawn M; Zhang Bin; Trojanowski John Q; Lee Virginia M-Y
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.
Neuron 2002;34(4):521-33.
2002: Forman Mark S; Schmidt M Luise; Kasturi Sanjay; Perl Daniel P; Lee Virginia M-Y; Trojanowski John Q
Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam.
The American journal of pathology 2002;160(5):1725-31.
2002: Judkins Alexander R; Forman Mark S; Uryu Kunihiro; Hinkle David A; Asbury Arthur K; Lee Virginia M-Y; Trojanowski John Q
Co-occurrence of Parkinson's disease with progressive supranuclear palsy.
Acta neuropathologica 2002;103(5):526-30.
2002: Nelson Peter T; Kondziolka Douglas; Wechsler Lawrence; Goldstein Steven; Gebel James; DeCesare Sharon; Elder Elaine M; Zhang Paul J; Jacobs Alan; McGrogan Michael; Lee Virginia M-Y; Trojanowski John Q
Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation.
The American journal of pathology 2002;160(4):1201-6.
2002: Trojanowski John Q
Neuropathological verisimilitude in animal models of Alzheimer's disease: key to elucidating neurodegenerative pathways and identifying new targets for drug discovery.
The American journal of pathology 2002;160(2):409-11.
2002: Mitchell Thomas W; Mufson Elliott J; Schneider Julie A; Cochran Elizabeth J; Nissanov Jonathan; Han Li-Ying; Bienias Julia L; Lee Virginia M -Y; Trojanowski John Q; Bennett David A; Arnold Steven E
Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease.
Annals of neurology 2002;51(2):182-9.
2002: Auluck Pavan K; Chan H Y Edwin; Trojanowski John Q; Lee Virginia M Y; Bonini Nancy M
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.
Science (New York, N.Y.) 2002;295(5556):865-8.
2002: Uryu Kunihiro; Laurer Helmut; McIntosh Tracy; Praticò Domenico; Martinez Daniel; Leight Susan; Lee Virginia M-Y; Trojanowski John Q
Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(2):446-54.
2002: Higuchi Makoto; Lee Virginia M Y; Trojanowski John Q
Tau and axonopathy in neurodegenerative disorders.
Neuromolecular medicine 2002;2(2):131-50.
2002: Raghupathi R; Conti A C; Graham D I; Krajewski S; Reed J C; Grady M S; Trojanowski J Q; McIntosh T K
Mild traumatic brain injury induces apoptotic cell death in the cortex that is preceded by decreases in cellular Bcl-2 immunoreactivity.
Neuroscience 2002;110(4):605-16.
2001: Trojanowski J Q; Dickson D
Update on the neuropathological diagnosis of frontotemporal dementias.
Journal of neuropathology and experimental neurology 2001;60(12):1123-6.
2001: Kahle P J; Neumann M; Ozmen L; Müller V; Odoy S; Okamoto N; Jacobsen H; Iwatsubo T; Trojanowski J Q; Takahashi H; Wakabayashi K; Bogdanovic N; Riederer P; Kretzschmar H A; Haass C
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model.
The American journal of pathology 2001;159(6):2215-25.
2001: Giasson B I; Duda J E; Forman M S; Lee V M; Trojanowski J Q
Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons.
Experimental neurology 2001;172(2):354-62.
2001: Zhuang Z P; Kung M P; Hou C; Plössl K; Skovronsky D; Gur T L; Trojanowski J Q; Lee V M; Kung H F
IBOX(2-(4'-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain.
Nuclear medicine and biology 2001;28(8):887-94.
2001: Lippa C F; Schmidt M L; Lee V M; Trojanowski J Q
Alpha-synuclein in familial Alzheimer disease: epitope mapping parallels dementia with Lewy bodies and Parkinson disease.
Archives of neurology 2001;58(11):1817-20.
2001: McKhann G M; Albert M S; Grossman M; Miller B; Dickson D; Trojanowski J Q;
Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease.
Archives of neurology 2001;58(11):1803-9.
2001: Schmidt M L; Zhukareva V; Perl D P; Sheridan S K; Schuck T; Lee V M; Trojanowski J Q
Spinal cord neurofibrillary pathology in Alzheimer disease and Guam Parkinsonism-dementia complex.
Journal of neuropathology and experimental neurology 2001;60(11):1075-86.
2001: Laurer H L; Bareyre F M; Lee V M; Trojanowski J Q; Longhi L; Hoover R; Saatman K E; Raghupathi R; Hoshino S; Grady M S; McIntosh T K
Mild head injury increasing the brain's vulnerability to a second concussive impact.
Journal of neurosurgery 2001;95(5):859-70.
2001: Longhi L; Saatman K E; Raghupathi R; Laurer H L; Lenzlinger P M; Riess P; Neugebauer E; Trojanowski J Q; Lee V M; Grady M S; Graham D I; McIntosh T K
A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(11):1241-58.
2001: Chou T T; Trojanowski J Q; Lee V M
p38 mitogen-activated protein kinase-independent induction of gadd45 expression in nerve growth factor-induced apoptosis in medulloblastomas.
The Journal of biological chemistry 2001;276(44):41120-7.
2001: Paxinou E; Chen Q; Weisse M; Giasson B I; Norris E H; Rueter S M; Trojanowski J Q; Lee V M; Ischiropoulos H
Induction of alpha-synuclein aggregation by intracellular nitrative insult.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(20):8053-61.
2001: Yoshiyama Y; Lee V M; Trojanowski J Q
Frontotemporal dementia and tauopathy.
Current neurology and neuroscience reports 2001;1(5):413-21.
2001: Rockenstein E; Hansen L A; Mallory M; Trojanowski J Q; Galasko D; Masliah E
Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease.
Brain research 2001;914(1-2):48-56.
2001: Schmidt M L; Schuck T; Sheridan S; Kung M P; Kung H; Zhuang Z P; Bergeron C; Lamarche J S; Skovronsky D; Giasson B I; Lee V M; Trojanowski J Q
The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains.
The American journal of pathology 2001;159(3):937-43.
2001: Arnold S E; Han L Y; Moberg P J; Turetsky B I; Gur R E; Trojanowski J Q; Hahn C G
Dysregulation of olfactory receptor neuron lineage in schizophrenia.
Archives of general psychiatry 2001;58(9):829-35.
2001: Ishihara T; Higuchi M; Zhang B; Yoshiyama Y; Hong M; Trojanowski J Q; Lee V M
Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(16):6026-35.
2001: Lee C W; Zhuang Z P; Kung M P; Plössl K; Skovronsky D; Gur T; Hou C; Trojanowski J Q; Lee V M; Kung H F
Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain.
Journal of medicinal chemistry 2001;44(14):2270-5.
2001: Shafiq M; Nee L; Grafman J; Tresser N; Lee V M; Trojanowski J Q; Lippa C F
Frontotemporal dementia: report of a familial case.
Neurology 2001;56(11 Suppl 4):S31-4.
2001: Lee V M; Trojanowski J Q
Transgenic mouse models of tauopathies: prospects for animal models of Pick's disease.
Neurology 2001;56(11 Suppl 4):S26-30.
2001: Zhuang Z P; Kung M P; Hou C; Skovronsky D M; Gur T L; Plössl K; Trojanowski J Q; Lee V M; Kung H F
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
Journal of medicinal chemistry 2001;44(12):1905-14.
2001: Schmidt M L; Zhukareva V; Newell K L; Lee V M; Trojanowski J Q
Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease.
Acta neuropathologica 2001;101(5):518-24.
2001: Vogelsberg-Ragaglia V; Schuck T; Trojanowski J Q; Lee V M
PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus.
Experimental neurology 2001;168(2):402-12.
2001: Galvin J E; Schuck T M; Lee V M; Trojanowski J Q
Differential expression and distribution of alpha-, beta-, and gamma-synuclein in the developing human substantia nigra.
Experimental neurology 2001;168(2):347-55.
2001: Poorkaj P; Grossman M; Steinbart E; Payami H; Sadovnick A; Nochlin D; Tabira T; Trojanowski J Q; Borson S; Galasko D; Reich S; Quinn B; Schellenberg G; Bird T D
Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia.
Archives of neurology 2001;58(3):383-7.
2001: Freed C R; Greene P E; Breeze R E; Tsai W Y; DuMouchel W; Kao R; Dillon S; Winfield H; Culver S; Trojanowski J Q; Eidelberg D; Fahn S
Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
The New England journal of medicine 2001;344(10):710-9.
2001: Zhukareva V; Vogelsberg-Ragaglia V; Van Deerlin V M; Bruce J; Shuck T; Grossman M; Clark C M; Arnold S E; Masliah E; Galasko D; Trojanowski J Q; Lee V M
Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia.
Annals of neurology 2001;49(2):165-75.
2001: Galvin J E; Lee V M; Trojanowski J Q
Synucleinopathies: clinical and pathological implications.
Archives of neurology 2001;58(2):186-90.
2001: Ishihara T; Zhang B; Higuchi M; Yoshiyama Y; Trojanowski J Q; Lee V M
Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.
The American journal of pathology 2001;158(2):555-62.
2001: Grotzer M A; Janss A J; Fung K M; Sutton L N; Zhao H; Trojanowski J Q; Rorke L B; Phillips P C
Abundance of apoptotic neoplastic cells in diagnostic biopsy samples is not a prognostic factor in childhood primitive neuroectodermal tumors of the central nervous system.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2001;23(1):25-9.
2001: Giasson B I; Murray I V; Trojanowski J Q; Lee V M
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.
The Journal of biological chemistry 2001;276(4):2380-6.
2001: Lee V M; Goedert M; Trojanowski J Q
Neurodegenerative tauopathies.
Annual review of neuroscience 2001;24():1121-59.
2000: Forman M S; Lee V M; Trojanowski J Q
New insights into genetic and molecular mechanisms of brain degeneration in tauopathies.
Journal of chemical neuroanatomy 2000;20(3-4):225-44.
2000: Lippa C F; Zhukareva V; Kawarai T; Uryu K; Shafiq M; Nee L E; Grafman J; Liang Y; St George-Hyslop P H; Trojanowski J Q; Lee V M
Frontotemporal dementia with novel tau pathology and a Glu342Val tau mutation.
Annals of neurology 2000;48(6):850-8.
2000: Vogelsberg-Ragaglia V; Bruce J; Richter-Landsberg C; Zhang B; Hong M; Trojanowski J Q; Lee V M
Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells.
Molecular biology of the cell 2000;11(12):4093-104.
2000: Mitchell T W; Nissanov J; Han L Y; Mufson E J; Schneider J A; Cochran E J; Bennett D A; Lee V M; Trojanowski J Q; Arnold S E
Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(12):1627-38.
2000: Arnold S E; Han L Y; Clark C M; Grossman M; Trojanowski J Q
Quantitative neurohistological features of frontotemporal degeneration.
Neurobiology of aging 2000;21(6):913-9.
2000: Schmidt M L; Garruto R; Chen J; Lee V M; Trojanowski J Q
Tau epitopes in spinal cord neurofibrillary lesions in Chamorros of Guam.
Neuroreport 2000;11(16):3427-30.
2000: Praticò D; Clark C M; Lee V M; Trojanowski J Q; Rokach J; FitzGerald G A
Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity.
Annals of neurology 2000;48(5):809-12.
2000: Duda J E; Giasson B I; Chen Q; Gur T L; Hurtig H I; Stern M B; Gollomp S M; Ischiropoulos H; Lee V M; Trojanowski J Q
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.
The American journal of pathology 2000;157(5):1439-45.
2000: Giasson B I; Duda J E; Murray I V; Chen Q; Souza J M; Hurtig H I; Ischiropoulos H; Trojanowski J Q; Lee V M
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.
Science (New York, N.Y.) 2000;290(5493):985-9.
2000: Richter-Landsberg C; Gorath M; Trojanowski J Q; Lee V M
alpha-synuclein is developmentally expressed in cultured rat brain oligodendrocytes.
Journal of neuroscience research 2000;62(1):9-14.
2000: Duda J E; Giasson B I; Gur T L; Montine T J; Robertson D; Biaggioni I; Hurtig H I; Stern M B; Gollomp S M; Grossman M; Lee V M; Trojanowski J Q
Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy.
Journal of neuropathology and experimental neurology 2000;59(9):830-41.
2000: Galvin J E; Nakamura M; McIntosh T K; Saatman K E; Sampathu D; Raghupathi R; Lee V M; Trojanowski J Q
Neurofilament-rich intraneuronal inclusions exacerbate neurodegenerative sequelae of brain trauma in NFH/LacZ transgenic mice.
Experimental neurology 2000;165(1):77-89.
2000: Galvin J E; Giasson B; Hurtig H I; Lee V M; Trojanowski J Q
Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology.
The American journal of pathology 2000;157(2):361-8.
2000: Grotzer M A; Janss A J; Phillips P C; Trojanowski J Q
Neurotrophin receptor TrkC predicts good clinical outcome in medulloblastoma and other primitive neuroectodermal brain tumors.
Klinische Pädiatrie 2000;212(4):196-9.
2000: Ginsberg S D; Hemby S E; Lee V M; Eberwine J H; Trojanowski J Q
Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons.
Annals of neurology 2000;48(1):77-87.
2000: Boockvar J A; Telfeian A; Baltuch G H; Skolnick B; Simuni T; Stern M; Schmidt M L; Trojanowski J Q
Long-term deep brain stimulation in a patient with essential tremor: clinical response and postmortem correlation with stimulator termination sites in ventral thalamus. Case report.
Journal of neurosurgery 2000;93(1):140-4.
2000: Duda J E; Lee V M; Trojanowski J Q
Neuropathology of synuclein aggregates.
Journal of neuroscience research 2000;61(2):121-7.
2000: Talbot K; Young R A; Jolly-Tornetta C; Lee V M; Trojanowski J Q; Wolf B A
A frontal variant of Alzheimer's disease exhibits decreased calcium-independent phospholipase A2 activity in the prefrontal cortex.
Neurochemistry international 2000;37(1):17-31.
2000: Skovronsky D M; Zhang B; Kung M P; Kung H F; Trojanowski J Q; Lee V M
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7609-14.
2000: Praticò D; Trojanowski J Q
Inflammatory hypotheses: novel mechanisms of Alzheimer's neurodegeneration and new therapeutic targets?
Neurobiology of aging 2000;21(3):441-5; discussion 451-3.
2000: Hurtig H I; Trojanowski J Q; Galvin J; Ewbank D; Schmidt M L; Lee V M; Clark C M; Glosser G; Stern M B; Gollomp S M; Arnold S E
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease.
Neurology 2000;54(10):1916-21.
2000: Bruening W; Giasson B I; Klein-Szanto A J; Lee V M; Trojanowski J Q; Godwin A K
Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary.
Cancer 2000;88(9):2154-63.
2000: Probst A; Götz J; Wiederhold K H; Tolnay M; Mistl C; Jaton A L; Hong M; Ishihara T; Lee V M; Trojanowski J Q; Jakes R; Crowther R A; Spillantini M G; Bürki K; Goedert M
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein.
Acta neuropathologica 2000;99(5):469-81.
2000: Nakagawa Y; Reed L; Nakamura M; McIntosh T K; Smith D H; Saatman K E; Raghupathi R; Clemens J; Saido T C; Lee V M; Trojanowski J Q
Brain trauma in aged transgenic mice induces regression of established abeta deposits.
Experimental neurology 2000;163(1):244-52.
2000: Murphy D D; Rueter S M; Trojanowski J Q; Lee V M
Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(9):3214-20.
2000: Eggert A; Ikegaki N; Liu X; Chou T T; Lee V M; Trojanowski J Q; Brodeur G M
Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.
Oncogene 2000;19(16):2043-51.
2000: Higuchi M; Tashiro M; Arai H; Okamura N; Hara S; Higuchi S; Itoh M; Shin R W; Trojanowski J Q; Sasaki H
Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies.
Experimental neurology 2000;162(2):247-56.
2000: Grotzer M A; Janss A J; Fung K; Biegel J A; Sutton L N; Rorke L B; Zhao H; Cnaan A; Phillips P C; Lee V M; Trojanowski J Q
TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(5):1027-35.
2000: Giasson B I; Jakes R; Goedert M; Duda J E; Leight S; Trojanowski J Q; Lee V M
A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease.
Journal of neuroscience research 2000;59(4):528-33.
2000: Lippa C F; Schmidt M L; Nee L E; Bird T; Nochlin D; Hulette C; Mori H; Lee V M; Trojanowski J Q
AMY plaques in familial AD: comparison with sporadic Alzheimer's disease.
Neurology 2000;54(1):100-4.
2000: Chou T T; Trojanowski J Q; Lee V M
A novel apoptotic pathway induced by nerve growth factor-mediated TrkA activation in medulloblastoma.
The Journal of biological chemistry 2000;275(1):565-70.
2000: Trojanowski J Q; Lee V M
"Fatal attractions" of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders.
Annals of the New York Academy of Sciences 2000;924():62-7.
2000: Lee V M; Hartley R S; Trojanowski J Q
Neurobiology of human neurons (NT2N) grafted into mouse spinal cord: implications for improving therapy of spinal cord injury.
Progress in brain research 2000;128():299-307.
1999: Duda J E; Shah U; Arnold S E; Lee V M; Trojanowski J Q
The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases.
Experimental neurology 1999;160(2):515-22.
1999: Schmidt M L; Saido T C; Lee V M; Trojanowski J Q
Spatial relationship of AMY protein deposits and different species of Abeta peptides in amyloid plaques of the Alzheimer disease brain.
Journal of neuropathology and experimental neurology 1999;58(12):1227-33.
1999: Hartley R S; Trojanowski J Q; Lee V M
Differential effects of spinal cord gray and white matter on process outgrowth from grafted human NTERA2 neurons (NT2N, hNT).
The Journal of comparative neurology 1999;415(3):404-18.
1999: Trojanowski J Q; Clark C M; Arai H; Lee V M
Elevated levels of tau in cerebrospinal fluid: implications for the antemortem diagnosis of Alzheimer's disease elevated levels of tau in cerebrospinal fluid: implications for the antemortem diagnosis of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 1999;1(4-5):297-305.
1999: Ishihara T; Hong M; Zhang B; Nakagawa Y; Lee M K; Trojanowski J Q; Lee V M
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform.
Neuron 1999;24(3):751-62.
1999: Lee V M; Trojanowski J Q
Neurodegenerative tauopathies: human disease and transgenic mouse models.
Neuron 1999;24(3):507-10.
1999: Galvin J E; Uryu K; Lee V M; Trojanowski J Q
Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13450-5.
1999: Trojanowski J Q; Lee V M
Transgenic models of tauopathies and synucleinopathies.
Brain pathology (Zurich, Switzerland) 1999;9(4):733-9.
1999: Smith D H; Chen X H; Nonaka M; Trojanowski J Q; Lee V M; Saatman K E; Leoni M J; Xu B N; Wolf J A; Meaney D F
Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig.
Journal of neuropathology and experimental neurology 1999;58(9):982-92.
1999: Ginsberg S D; Galvin J E; Lee V M; Rorke L B; Dickson D W; Wolfe J H; Jones M Z; Trojanowski J Q
Accumulation of intracellular amyloid-beta peptide (A beta 1-40) in mucopolysaccharidosis brains.
Journal of neuropathology and experimental neurology 1999;58(8):815-24.
1999: Lieberman A P; Trojanowski J Q; Leonard D G; Chen K L; Barnett J L; Leverenz J B; Bird T D; Robitaille Y; Malandrini A; Fischbeck K H
Ataxin 1 and ataxin 3 in neuronal intranuclear inclusion disease.
Annals of neurology 1999;46(2):271-3.
1999: Wang J; Dickson D W; Trojanowski J Q; Lee V M
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.
Experimental neurology 1999;158(2):328-37.
1999: Nakagawa Y; Nakamura M; McIntosh T K; Rodriguez A; Berlin J A; Smith D H; Saatman K E; Raghupathi R; Clemens J; Saido T C; Schmidt M L; Lee V M; Trojanowski J Q
Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging.
The Journal of comparative neurology 1999;411(3):390-8.
1999: Jakes R; Crowther R A; Lee V M; Trojanowski J Q; Iwatsubo T; Goedert M
Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein.
Neuroscience letters 1999;269(1):13-6.
1999: Pino M V; Valerio M G; Miller G K; Larson J L; Rosolia D L; Jayyosi Z; Crouch C N; Trojanowski J Q; Geiger L E
Toxicologic and carcinogenic effects of the type IV phosphodiesterase inhibitor RP 73401 on the nasal olfactory tissue in rats.
Toxicologic pathology 1999;27(4):383-94.
1999: Nakamura M; Saatman K E; Galvin J E; Scherbel U; Raghupathi R; Trojanowski J Q; McIntosh T K
Increased vulnerability of NFH-LacZ transgenic mouse to traumatic brain injury-induced behavioral deficits and cortical damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(7):762-70.
1999: Scherbel U; Raghupathi R; Nakamura M; Saatman K E; Trojanowski J Q; Neugebauer E; Marino M W; McIntosh T K
Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8721-6.
1999: Tal-Singer R; Pichyangkura R; Chung E; Lasner T M; Randazzo B P; Trojanowski J Q; Fraser N W; Triezenberg S J
The transcriptional activation domain of VP16 is required for efficient infection and establishment of latency by HSV-1 in the murine peripheral and central nervous systems.
Virology 1999;259(1):20-33.
1999: Muir J K; Raghupathi R; Saatman K E; Wilson C A; Lee V M; Trojanowski J Q; Philips M F; McIntosh T K
Terminally differentiated human neurons survive and integrate following transplantation into the traumatically injured rat brain.
Journal of neurotrauma 1999;16(5):403-14.
1999: Büki A; Siman R; Trojanowski J Q; Povlishock J T
The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury.
Journal of neuropathology and experimental neurology 1999;58(4):365-75.
1999: Mirra S S; Murrell J R; Gearing M; Spillantini M G; Goedert M; Crowther R A; Levey A I; Jones R; Green J; Shoffner J M; Wainer B H; Schmidt M L; Trojanowski J Q; Ghetti B
Tau pathology in a family with dementia and a P301L mutation in tau.
Journal of neuropathology and experimental neurology 1999;58(4):335-45.
1999: Young R A; Talbot K; Gao Z Y; Trojanowski J Q; Wolf B A
Phospholipase pathway in Alzheimer's disease brains: decrease in Galphai in dorsolateral prefrontal cortex.
Brain research. Molecular brain research 1999;66(1-2):188-90.
1999: Lippa C F; Schmidt M L; Lee V M; Trojanowski J Q
Dementia with Lewy bodies.
Neurology 1999;52(4):893.
1999: Giasson B I; Uryu K; Trojanowski J Q; Lee V M
Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro.
The Journal of biological chemistry 1999;274(12):7619-22.
1999: Lippa C F; Schmidt M L; Lee V M; Trojanowski J Q
Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease.
Annals of neurology 1999;45(3):353-7.
1999: Aksenova M V; Aksenov M Y; Payne R M; Trojanowski J Q; Schmidt M L; Carney J M; Butterfield D A; Markesbery W R
Oxidation of cytosolic proteins and expression of creatine kinase BB in frontal lobe in different neurodegenerative disorders.
Dementia and geriatric cognitive disorders 1999;10(2):158-65.
1999: Iijima M; Tabira T; Poorkaj P; Schellenberg G D; Trojanowski J Q; Lee V M; Schmidt M L; Takahashi K; Nabika T; Matsumoto T; Yamashita Y; Yoshioka S; Ishino H
A distinct familial presenile dementia with a novel missense mutation in the tau gene.
Neuroreport 1999;10(3):497-501.
1999: Ginsberg S D; Crino P B; Hemby S E; Weingarten J A; Lee V M; Eberwine J H; Trojanowski J Q
Predominance of neuronal mRNAs in individual Alzheimer's disease senile plaques.
Annals of neurology 1999;45(2):174-81.
1999: Philips M F; Muir J K; Saatman K E; Raghupathi R; Lee V M; Trojanowski J Q; McIntosh T K
Survival and integration of transplanted postmitotic human neurons following experimental brain injury in immunocompetent rats.
Journal of neurosurgery 1999;90(1):116-24.
1999: Hanzel D K; Trojanowski J Q; Johnston R F; Loring J F
High-throughput quantitative histological analysis of Alzheimer's disease pathology using a confocal digital microscanner.
Nature biotechnology 1999;17(1):53-7.
1999: Arnold S E; Trojanowski J Q; Parchi P
Protease resistant prion proteins are not present in sporadic "poor outcome" schizophrenia.
Journal of neurology, neurosurgery, and psychiatry 1999;66(1):90-2.
1999: Lee V M; Wang J; Trojanowski J Q
Purification of paired helical filament tau and normal tau from human brain tissue.
Methods in enzymology 1999;309():81-9.
1999: Galvin J E; Lee V M; Schmidt M L; Tu P H; Iwatsubo T; Trojanowski J Q
Pathobiology of the Lewy body.
Advances in neurology 1999;80():313-24.
1998: Praticò D; MY Lee V; Trojanowski J Q; Rokach J; Fitzgerald G A
Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(15):1777-83.
1998: Hong M; Zhukareva V; Vogelsberg-Ragaglia V; Wszolek Z; Reed L; Miller B I; Geschwind D H; Bird T D; McKeel D; Goate A; Morris J C; Wilhelmsen K C; Schellenberg G D; Trojanowski J Q; Lee V M
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
Science (New York, N.Y.) 1998;282(5395):1914-7.
1998: Joyce J N; Murray A M; Hurtig H I; Gottlieb G L; Trojanowski J Q
Loss of dopamine D2 receptors in Alzheimer's disease with parkinsonism but not Parkinson's or Alzheimer's disease.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(6):472-80.
1998: Arnold S E; Smutzer G S; Trojanowski J Q; Moberg P J
Cellular and molecular neuropathology of the olfactory epithelium and central olfactory pathways in Alzheimer's disease and schizophrenia.
Annals of the New York Academy of Sciences 1998;855():762-75.
1998: Borlongan C V; Tajima Y; Trojanowski J Q; Lee V M; Sanberg P R
Cerebral ischemia and CNS transplantation: differential effects of grafted fetal rat striatal cells and human neurons derived from a clonal cell line.
Neuroreport 1998;9(16):3703-9.
1998: Ginsberg S D; Galvin J E; Chiu T S; Lee V M; Masliah E; Trojanowski J Q
RNA sequestration to pathological lesions of neurodegenerative diseases.
Acta neuropathologica 1998;96(5):487-94.
1998: Hosoda R; Saido T C; Otvos L; Arai T; Mann D M; Lee V M; Trojanowski J Q; Iwatsubo T
Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains.
Journal of neuropathology and experimental neurology 1998;57(11):1089-95.
1998: Lippa C F; Fujiwara H; Mann D M; Giasson B; Baba M; Schmidt M L; Nee L E; O'Connell B; Pollen D A; St George-Hyslop P; Ghetti B; Nochlin D; Bird T D; Cairns N J; Lee V M; Iwatsubo T; Trojanowski J Q
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.
The American journal of pathology 1998;153(5):1365-70.
1998: Pierce J E; Smith D H; Trojanowski J Q; McIntosh T K
Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats.
Neuroscience 1998;87(2):359-69.
1998: Trojanowski J Q; Goedert M; Iwatsubo T; Lee V M
Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia.
Cell death and differentiation 1998;5(10):832-7.
1998: Clark L N; Poorkaj P; Wszolek Z; Geschwind D H; Nasreddine Z S; Miller B; Li D; Payami H; Awert F; Markopoulou K; Andreadis A; D'Souza I; Lee V M; Reed L; Trojanowski J Q; Zhukareva V; Bird T; Schellenberg G; Wilhelmsen K C
Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13103-7.
1998: Tu P H; Galvin J E; Baba M; Giasson B; Tomita T; Leight S; Nakajo S; Iwatsubo T; Trojanowski J Q; Lee V M
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.
Annals of neurology 1998;44(3):415-22.
1998: Smith D H; Nakamura M; McIntosh T K; Wang J; Rodríguez A; Chen X H; Raghupathi R; Saatman K E; Clemens J; Schmidt M L; Lee V M; Trojanowski J Q
Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein.
The American journal of pathology 1998;153(3):1005-10.
1998: McIntosh T K; Saatman K E; Raghupathi R; Graham D I; Smith D H; Lee V M; Trojanowski J Q
The Dorothy Russell Memorial Lecture. The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms.
Neuropathology and applied neurobiology 1998;24(4):251-67.
1998: Hurst R W; Bagley L J; Galetta S; Glosser G; Lieberman A P; Trojanowski J; Sinson G; Stecker M; Zager E; Raps E C; Flamm E S
Dementia resulting from dural arteriovenous fistulas: the pathologic findings of venous hypertensive encephalopathy.
AJNR. American journal of neuroradiology 1998;19(7):1267-73.
1998: Conti A C; Raghupathi R; Trojanowski J Q; McIntosh T K
Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(15):5663-72.
1998: Hutton M; Lendon C L; Rizzu P; Baker M; Froelich S; Houlden H; Pickering-Brown S; Chakraverty S; Isaacs A; Grover A; Hackett J; Adamson J; Lincoln S; Dickson D; Davies P; Petersen R C; Stevens M; de Graaff E; Wauters E; van Baren J; Hillebrand M; Joosse M; Kwon J M; Nowotny P; Che L K; Norton J; Morris J C; Reed L A; Trojanowski J; Basun H; Lannfelt L; Neystat M; Fahn S; Dark F; Tannenberg T; Dodd P R; Hayward N; Kwok J B; Schofield P R; Andreadis A; Snowden J; Craufurd D; Neary D; Owen F; Oostra B A; Hardy J; Goate A; van Swieten J; Mann D; Lynch T; Heutink P
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.
Nature 1998;393(6686):702-5.
1998: Tanaka S; Chen X; Xia Y; Kang D E; Matoh N; Sundsmo M; Thomas R G; Katzman R; Thal L J; Trojanowski J Q; Saitoh T; Ueda K; Masliah E
Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease.
Neurology 1998;50(6):1556-62.
1998: Trojanowski J Q; Growdon J H
A new consensus report on biomarkers for the early antemortem diagnosis of Alzheimer disease: current status, relevance to drug discovery, and recommendations for future research.
Journal of neuropathology and experimental neurology 1998;57(6):643-4.
1998: Reed L A; Schmidt M L; Wszolek Z K; Balin B J; Soontornniyomkij V; Lee V M; Trojanowski J Q; Schelper R L
The neuropathology of a chromosome 17-linked autosomal dominant parkinsonism and dementia ("pallido-ponto-nigral degeneration").
Journal of neuropathology and experimental neurology 1998;57(6):588-601.
1998: Itabashi S; Arai H; Matsui T; Matsushita S; Muramatsu T; Higuchi S; Trojanowski J Q; Sasaki H
Absence of association of alpha1-antichymotrypsin polymorphisms with Alzheimer's disease: a report on autopsy-confirmed cases.
Experimental neurology 1998;151(2):237-40.
1998: Tajima Y; Molina R P; Rorke L B; Kaplan D R; Radeke M; Feinstein S C; Lee V M; Trojanowski J Q
Neurotrophins and neuronal versus glial differentiation in medulloblastomas and other pediatric brain tumors.
Acta neuropathologica 1998;95(4):325-32.
1998: Smutzer G; Lee V M; Trojanowski J Q; Arnold S E
Human olfactory mucosa in schizophrenia.
The Annals of otology, rhinology, and laryngology 1998;107(4):349-55.
1998: Baba M; Nakajo S; Tu P H; Tomita T; Nakaya K; Lee V M; Trojanowski J Q; Iwatsubo T
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
The American journal of pathology 1998;152(4):879-84.
1998: Arai H; Clark C M; Ewbank D C; Takase S; Higuchi S; Miura M; Seki H; Higuchi M; Matsui T; Lee V M; Trojanowski J Q; Sasaki H
Cerebrospinal fluid tau protein as a potential diagnostic marker in Alzheimer's disease.
Neurobiology of aging 1998;19(2):125-6.
1998: Lieberman A P; Robitaille Y; Trojanowski J Q; Dickson D W; Fischbeck K H
Polyglutamine-containing aggregates in neuronal intranuclear inclusion disease.
Lancet 1998;351(9106):884.
1998: Kesari S; Lasner T M; Balsara K R; Randazzo B P; Lee V M; Trojanowski J Q; Fraser N W
A neuroattenuated ICP34.5-deficient herpes simplex virus type 1 replicates in ependymal cells of the murine central nervous system.
The Journal of general virology 1998;79 ( Pt 3)():525-36.
1998: Murai H; Pierce J E; Raghupathi R; Smith D H; Saatman K E; Trojanowski J Q; Lee V M; Loring J F; Eckman C; Younkin S; McIntosh T K
Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury.
The Journal of comparative neurology 1998;392(4):428-38.
1998: Arnold S E; Trojanowski J Q; Gur R E; Blackwell P; Han L Y; Choi C
Absence of neurodegeneration and neural injury in the cerebral cortex in a sample of elderly patients with schizophrenia.
Archives of general psychiatry 1998;55(3):225-32.
1998: Lasner T M; Tal-Singer R; Kesari S; Lee V M; Trojanowski J Q; Fraser N W
Toxicity and neuronal infection of a HSV-1 ICP34.5 mutant in nude mice.
Journal of neurovirology 1998;4(1):100-5.
1998: Borlongan C V; Tajima Y; Trojanowski J Q; Lee V M; Sanberg P R
Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats.
Experimental neurology 1998;149(2):310-21.
1998: Schmidt M L; Lee V M; Saido T; Perl D; Schuck T; Iwatsubo T; Trojanowski J Q
Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging.
Acta neuropathologica 1998;95(2):117-22.
1998: Lieberman A P; Trojanowski J Q; Lee V M; Balin B J; Ding X S; Greenberg J; Morrison D; Reivich M; Grossman M
Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease.
Annals of neurology 1998;43(2):259-65.
1998: Trojanowski J Q; Lee V M
Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia.
Archives of neurology 1998;55(2):151-2.
1998: Thomson J A; Marshall V S; Trojanowski J Q
Neural differentiation of rhesus embryonic stem cells.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1998;106(1):149-56; discussion 156-7.
1998: Egan C L; Viglione-Schneck M J; Walsh L J; Green B; Trojanowski J Q; Whitaker-Menezes D; Murphy G F
Characterization of unmyelinated axons uniting epidermal and dermal immune cells in primate and murine skin.
Journal of cutaneous pathology 1998;25(1):20-9.
1997: Zhang B; Tu P; Abtahian F; Trojanowski J Q; Lee V M
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation.
The Journal of cell biology 1997;139(5):1307-15.
1997: Shin R W; Ogino K; Kondo A; Saido T C; Trojanowski J Q; Kitamoto T; Tateishi J
Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8187-93.
1997: Smith D H; Chen X H; Pierce J E; Wolf J A; Trojanowski J Q; Graham D I; McIntosh T K
Progressive atrophy and neuron death for one year following brain trauma in the rat.
Journal of neurotrauma 1997;14(10):715-27.
1997: Galvin J E; Lee V M; Baba M; Mann D M; Dickson D W; Yamaguchi H; Schmidt M L; Iwatsubo T; Trojanowski J Q
Monoclonal antibodies to purified cortical Lewy bodies recognize the mid-size neurofilament subunit.
Annals of neurology 1997;42(4):595-603.
1997: Reed L A; Grabowski T J; Schmidt M L; Morris J C; Goate A; Solodkin A; Van Hoesen G W; Schelper R L; Talbot C J; Wragg M A; Trojanowski J Q
Autosomal dominant dementia with widespread neurofibrillary tangles.
Annals of neurology 1997;42(4):564-72.
1997: Arai H; Terajima M; Miura M; Higuchi S; Muramatsu T; Matsushita S; Machida N; Nakagawa T; Lee V M; Trojanowski J Q; Sasaki H
Effect of genetic risk factors and disease progression on the cerebrospinal fluid tau levels in Alzheimer's disease.
Journal of the American Geriatrics Society 1997;45(10):1228-31.
1997: Hyman B T; Trojanowski J Q
Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease.
Journal of neuropathology and experimental neurology 1997;56(10):1095-7.
1997: Chou T T; Trojanowski J Q; Lee V M
Neurotrophin signal transduction in medulloblastoma.
Journal of neuroscience research 1997;49(5):522-7.
1997: Paulson H L; Perez M K; Trottier Y; Trojanowski J Q; Subramony S H; Das S S; Vig P; Mandel J L; Fischbeck K H; Pittman R N
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.
Neuron 1997;19(2):333-44.
1997: Spillantini M G; Schmidt M L; Lee V M; Trojanowski J Q; Jakes R; Goedert M
Alpha-synuclein in Lewy bodies.
Nature 1997;388(6645):839-40.
1997: Merrick S E; Trojanowski J Q; Lee V M
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(15):5726-37.
1997: Trojanowski J Q; Clark C M; Schmidt M L; Arnold S E; Lee V M
Strategies for improving the postmortem neuropathological diagnosis of Alzheimer's disease.
Neurobiology of aging 1997;18(4 Suppl):S75-9.
1997: Fung K M; Peringa J; Venkatachalam S; Lee V M; Trojanowski J Q
Coordinate reduction in cell proliferation and cell death in mouse olfactory epithelium from birth to maturity.
Brain research 1997;761(2):347-51.
1997: Arai H; Morikawa Y; Higuchi M; Matsui T; Clark C M; Miura M; Machida N; Lee V M; Trojanowski J Q; Sasaki H
Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology.
Biochemical and biophysical research communications 1997;236(2):262-4.
1997: Schmidt M L; Lee V M; Forman M; Chiu T S; Trojanowski J Q
Monoclonal antibodies to a 100-kd protein reveal abundant A beta-negative plaques throughout gray matter of Alzheimer's disease brains.
The American journal of pathology 1997;151(1):69-80.
1997: Crino P B; Trojanowski J Q; Eberwine J
Internexin, MAP1B, and nestin in cortical dysplasia as markers of developmental maturity.
Acta neuropathologica 1997;93(6):619-27.
1997: Arnold S E; Joo E; Martinoli M G; Roy N; Trojanowski J Q; Gur R E; Cannon T; Price R A
Apolipoprotein E genotype in schizophrenia: frequency, age of onset, and neuropathologic features.
Neuroreport 1997;8(6):1523-6.
1997: Rorke L B; Trojanowski J Q; Lee V M; Zimmerman R A; Sutton L N; Biegel J A; Goldwein J W; Packer R J
Primitive neuroectodermal tumors of the central nervous system.
Brain pathology (Zurich, Switzerland) 1997;7(2):765-84.
1997: Tu P H; Gurney M E; Julien J P; Lee V M; Trojanowski J Q
Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease.
Laboratory investigation; a journal of technical methods and pathology 1997;76(4):441-56.
1997: Povlishock J T; Marmarou A; McIntosh T; Trojanowski J Q; Moroi J
Impact acceleration injury in the rat: evidence for focal axolemmal change and related neurofilament sidearm alteration.
Journal of neuropathology and experimental neurology 1997;56(4):347-59.
1997: Trojanowski J Q; Kleppner S R; Hartley R S; Miyazono M; Fraser N W; Kesari S; Lee V M
Transfectable and transplantable postmitotic human neurons: a potential "platform" for gene therapy of nervous system diseases.
Experimental neurology 1997;144(1):92-7.
1997: Sinson G; Perri B R; Trojanowski J Q; Flamm E S; McIntosh T K
Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury.
Journal of neurosurgery 1997;86(3):511-8.
1997: Conrad C; Andreadis A; Trojanowski J Q; Dickson D W; Kang D; Chen X; Wiederholt W; Hansen L; Masliah E; Thal L J; Katzman R; Xia Y; Saitoh T
Genetic evidence for the involvement of tau in progressive supranuclear palsy.
Annals of neurology 1997;41(2):277-81.
1997: Ginsberg S D; Crino P B; Lee V M; Eberwine J H; Trojanowski J Q
Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques.
Annals of neurology 1997;41(2):200-9.
1997: Tu P H; Robinson K A; de Snoo F; Eyer J; Peterson A; Lee V M; Trojanowski J Q
Selective degeneration fo Purkinje cells with Lewy body-like inclusions in aged NFHLACZ transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(3):1064-74.
1997: Muragaki Y; Chou T T; Kaplan D R; Trojanowski J Q; Lee V M
Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(2):530-42.
1996: Higuchi S; Arai H; Nakagawa T; Muramatsu T; Sasaki H; Trojanowski J Q
The apolipoprotein E gene in Binswanger's disease and vascular dementia.
Clinical genetics 1996;50(6):459-61.
1996: Miyazono M; Nowell P C; Finan J L; Lee V M; Trojanowski J Q
Long-term integration and neuronal differentiation of human embryonal carcinoma cells (NTera-2) transplanted into the caudoputamen of nude mice.
The Journal of comparative neurology 1996;376(4):603-13.
1996: Lasner T M; Kesari S; Brown S M; Lee V M; Fraser N W; Trojanowski J Q
Therapy of a murine model of pediatric brain tumors using a herpes simplex virus type-1 ICP34.5 mutant and demonstration of viral replication within the CNS.
Journal of neuropathology and experimental neurology 1996;55(12):1259-69.
1996: Iwatsubo T; Saido T C; Mann D M; Lee V M; Trojanowski J Q
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.
The American journal of pathology 1996;149(6):1823-30.
1996: Trojanowski J Q
The cellular and molecular correlates of cognitive impairments in the Alzheimer's disease brain.
Neurobiology of aging 1996;17(6):941-3; discussion 945-7.
1996: Crino P B; Trojanowski J Q; Dichter M A; Eberwine J
Embryonic neuronal markers in tuberous sclerosis: single-cell molecular pathology.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14152-7.
1996: Mawal-Dewan M; Schmidt M L; Balin B; Perl D P; Lee V M; Trojanowski J Q
Identification of phosphorylation sites in PHF-TAU from patients with Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex.
Journal of neuropathology and experimental neurology 1996;55(10):1051-9.
1996: Arnold S E; Trojanowski J Q
Recent advances in defining the neuropathology of schizophrenia.
Acta neuropathologica 1996;92(3):217-31.
1996: Mu X; He J; Anderson D W; Trojanowski J Q; Springer J E
Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons.
Annals of neurology 1996;40(3):379-86.
1996: Kesari S; Lee V M; Brown S M; Trojanowski J Q; Fraser N W
Selective vulnerability of mouse CNS neurons to latent infection with a neuroattenuated herpes simplex virus-1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(18):5644-53.
1996: Cook D G; Sung J C; Golde T E; Felsenstein K M; Wojczyk B S; Tanzi R E; Trojanowski J Q; Lee V M; Doms R W
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9223-8.
1996: Iwatsubo T; Yamaguchi H; Fujimuro M; Yokosawa H; Ihara Y; Trojanowski J Q; Lee V M
Lewy bodies: purification from diffuse Lewy body disease brains.
Annals of the New York Academy of Sciences 1996;786():195-205.
1996: Parchi P; Castellani R; Capellari S; Ghetti B; Young K; Chen S G; Farlow M; Dickson D W; Sima A A; Trojanowski J Q; Petersen R B; Gambetti P
Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease.
Annals of neurology 1996;39(6):767-78.
1996: McLendon R E; Fung K M; Bentley R C; Ahmed Rasheed B K; Trojanowski J Q; Bigner S H; Bigner D D; Friedman H S
Production and characterization of two ependymoma xenografts.
Journal of neuropathology and experimental neurology 1996;55(5):540-8.
1996: Schmidt M L; Huang R; Martin J A; Henley J; Mawal-Dewan M; Hurtig H I; Lee V M; Trojanowski J Q
Neurofibrillary tangles in progressive supranuclear palsy contain the same tau epitopes identified in Alzheimer's disease PHFtau.
Journal of neuropathology and experimental neurology 1996;55(5):534-9.
1996: Iwatsubo T; Yamaguchi H; Fujimuro M; Yokosawa H; Ihara Y; Trojanowski J Q; Lee V M
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
The American journal of pathology 1996;148(5):1517-29.
1996: Arnold S E; Trojanowski J Q
Human fetal hippocampal development: II. The neuronal cytoskeleton.
The Journal of comparative neurology 1996;367(2):293-307.
1996: Arnold S E; Trojanowski J Q
Human fetal hippocampal development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features.
The Journal of comparative neurology 1996;367(2):274-92.
1996: Janss A J; Yachnis A T; Silber J H; Trojanowski J Q; Lee V M; Sutton L N; Perilongo G; Rorke L B; Phillips P C
Glial differentiation predicts poor clinical outcome in primitive neuroectodermal brain tumors.
Annals of neurology 1996;39(4):481-9.
1996: Tu P H; Raju P; Robinson K A; Gurney M E; Trojanowski J Q; Lee V M
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):3155-60.
1996: Washiyama K; Muragaki Y; Rorke L B; Lee V M; Feinstein S C; Radeke M J; Blumberg D; Kaplan D R; Trojanowski J Q
Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system.
The American journal of pathology 1996;148(3):929-40.
1996: Woodruff-Pak D S; Trojanowski J Q
The older rabbit as an animal model: implications for Alzheimer's disease.
Neurobiology of aging 1996;17(2):283-90.
1996: Loring J F; Paszty C; Rose A; McIntosh T K; Murai H; Pierce J E; Schramm S R; Wymore K; Lee V M; Trojanowski J Q; Peterson K R
Rational design of an animal model for Alzheimer's disease: introduction of multiple human genomic transgenes to reproduce AD pathology in a rodent.
Neurobiology of aging 1996;17(2):173-82.
1996: Turner R S; Kenyon L C; Trojanowski J Q; Gonatas N; Grossman M
Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia.
Annals of neurology 1996;39(2):166-73.
1996: Yamaguchi S; Nakagawa T; Arai H; Sasaki H; Higuchi S; Trojanowski J Q
Temporal progression of hippocampal atrophy and apolipoprotein E gene in Alzheimer's disease.
Journal of the American Geriatrics Society 1996;44(2):216-7.
1996: Pierce J E; Trojanowski J Q; Graham D I; Smith D H; McIntosh T K
Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(3):1083-90.
1996: Arnold S E; Franz B R; Trojanowski J Q; Moberg P J; Gur R E
Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia.
Acta neuropathologica 1996;91(3):269-77.
1996: Schmidt M L; Martin J A; Lee V M; Trojanowski J Q
Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders.
Acta neuropathologica 1996;91(5):475-81.
1996: Arnold S E; Trojanowski J Q
Cognitive impairment in elderly schizophrenia: a dementia (still) lacking distinctive histopathology.
Schizophrenia bulletin 1996;22(1):5-9.
1995: Peringa J; Fung K M; Muragaki Y; Trojanowski J Q
The cellular and molecular biology of medulloblastoma.
Current opinion in neurology 1995;8(6):437-40.
1995: Trojanowski J Q; Lee V M
Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(15):1570-6.
1995: Rink A; Fung K M; Trojanowski J Q; Lee V M; Neugebauer E; McIntosh T K
Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.
The American journal of pathology 1995;147(6):1575-83.
1995: Kesari S; Randazzo B P; Valyi-Nagy T; Huang Q S; Brown S M; MacLean A R; Lee V M; Trojanowski J Q; Fraser N W
Therapy of experimental human brain tumors using a neuroattenuated herpes simplex virus mutant.
Laboratory investigation; a journal of technical methods and pathology 1995;73(5):636-48.
1995: Shin R W; Lee V M; Trojanowski J Q
Neurofibrillary pathology and aluminum in Alzheimer's disease.
Histology and histopathology 1995;10(4):969-78.
1995: Seubert P; Mawal-Dewan M; Barbour R; Jakes R; Goedert M; Johnson G V; Litersky J M; Schenk D; Lieberburg I; Trojanowski J Q
Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.
The Journal of biological chemistry 1995;270(32):18917-22.
1995: Crino P B; Martin J A; Hill W D; Greenberg B; Lee V M; Trojanowski J Q
Beta-Amyloid peptide and amyloid precursor proteins in olfactory mucosa of patients with Alzheimer's disease, Parkinson's disease, and Down syndrome.
The Annals of otology, rhinology, and laryngology 1995;104(8):655-61.
1995: Schmidt M L; Robinson K A; Lee V M; Trojanowski J Q
Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy.
The American journal of pathology 1995;147(2):503-15.
1995: Miyazono M; Lee V M; Trojanowski J Q
Proliferation, cell death, and neuronal differentiation in transplanted human embryonal carcinoma (NTera2) cells depend on the graft site in nude and severe combined immunodeficient mice.
Laboratory investigation; a journal of technical methods and pathology 1995;73(2):273-83.
1995: Kleppner S R; Robinson K A; Trojanowski J Q; Lee V M
Transplanted human neurons derived from a teratocarcinoma cell line (NTera-2) mature, integrate, and survive for over 1 year in the nude mouse brain.
The Journal of comparative neurology 1995;357(4):618-32.
1995: Tu P H; Elder G; Lazzarini R A; Nelson D; Trojanowski J Q; Lee V M
Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits.
The Journal of cell biology 1995;129(6):1629-40.
1995: Fung K M; Lee V M; Trojanowski J Q
Dynamics of cell proliferation and cell death during the emergence of primitive neuroectodermal tumors of the immature central nervous system in transgenic mice.
The American journal of pathology 1995;146(6):1376-87.
1995: Muragaki Y; Timothy N; Leight S; Hempstead B L; Chao M V; Trojanowski J Q; Lee V M
Expression of trk receptors in the developing and adult human central and peripheral nervous system.
The Journal of comparative neurology 1995;356(3):387-97.
1995: Fung K M; Trojanowski J Q
Animal models of medulloblastomas and related primitive neuroectodermal tumors. A review.
Journal of neuropathology and experimental neurology 1995;54(3):285-96.
1995: Arnold S E; Franz B R; Gur R C; Gur R E; Shapiro R M; Moberg P J; Trojanowski J Q
Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions.
The American journal of psychiatry 1995;152(5):738-48.
1995: Arnold S E; Gur R E; Shapiro R M; Fisher K R; Moberg P J; Gibney M R; Gur R C; Blackwell P; Trojanowski J Q
Prospective clinicopathologic studies of schizophrenia: accrual and assessment of patients.
The American journal of psychiatry 1995;152(5):731-7.
1995: Trojanowski J Q; Shin R W; Schmidt M L; Lee V M
Relationship between plaques, tangles, and dystrophic processes in Alzheimer's disease.
Neurobiology of aging 1995;16(3):335-40; discussion 341-5.
1995: Trojanowski J Q; Arnold S E
In pursuit of the molecular neuropathology of schizophrenia.
Archives of general psychiatry 1995;52(4):274-6; discussion 277-8.
1995: Mantione J R; Kleppner S R; Miyazono M; Wertkin A M; Lee V M; Trojanowski J Q
Human neurons that constitutively secrete A beta do not induce Alzheimer's disease pathology following transplantation and long-term survival in the rodent brain.
Brain research 1995;671(2):333-7.
1995: Schmidt M L; Trojanowski J Q
Immunohistochemical detection of the effects of toxic injury on the central nervous system.
Neurochemistry international 1995;26(2):145-53.
1995: Higuchi S; Muramatsu T; Arai H; Hayashida M; Sasaki H; Trojanowski J Q
Polymorphisms of dopamine receptor and transporter genes and Parkinson's disease.
Journal of neural transmission. Parkinson's disease and dementia section 1995;10(2-3):107-13.
1995: Auer I A; Schmidt M L; Lee V M; Curry B; Suzuki K; Shin R W; Pentchev P G; Carstea E D; Trojanowski J Q
Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease.
Acta neuropathologica 1995;90(6):547-51.
1995: Martinoli M G; Trojanowski J Q; Schmidt M L; Arnold S E; Fujiwara T M; Lee V M; Hurtig H; Julien J P; Clark C
Association of apolipoprotein epsilon 4 allele and neuropathologic findings in patients with dementia.
Acta neuropathologica 1995;90(3):239-43.
1994: Mawal-Dewan M; Henley J; Van de Voorde A; Trojanowski J Q; Lee V M
The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases.
The Journal of biological chemistry 1994;269(49):30981-7.
1994: Garver T D; Harris K A; Lehman R A; Lee V M; Trojanowski J Q; Billingsley M L
Tau phosphorylation in human, primate, and rat brain: evidence that a pool of tau is highly phosphorylated in vivo and is rapidly dephosphorylated in vitro.
Journal of neurochemistry 1994;63(6):2279-87.
1994: Schmidt M L; DiDario A G; Otvos L; Hoshi N; Kant J A; Lee V M; Trojanowski J Q
Plaque-associated neuronal proteins: a recurrent motif in neuritic amyloid deposits throughout diverse cortical areas of the Alzheimer's disease brain.
Experimental neurology 1994;130(2):311-22.
1994: Trojanowski J Q; Lee V M
Phosphorylation of neuronal cytoskeletal proteins in Alzheimer's disease and Lewy body dementias.
Annals of the New York Academy of Sciences 1994;747():92-109.
1994: Yachnis A T; Trojanowski J Q
Studies of childhood brain tumors using immunohistochemistry and microwave technology: methodological considerations.
Journal of neuroscience methods 1994;55(2):191-200.
1994: Muramatsu T; Higuchi S; Arai H; Sasaki H; Yamada K; Hayashida M; Trojanowski J Q
Apolipoprotein E epsilon 4 allele distribution in alcoholic dementia and in Alzheimer's disease in Japan.
Annals of neurology 1994;36(5):797-9.
1994: Cole J S; Messing A; Trojanowski J Q; Lee V M
Modulation of axon diameter and neurofilaments by hypomyelinating Schwann cells in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(11 Pt 2):6956-66.
1994: Arai H; Higuchi S; Muramatsu T; Iwatsubo T; Sasaki H; Trojanowski J Q
Apolipoprotein E gene in diffuse Lewy body disease with or without co-existing Alzheimer's disease.
Lancet 1994;344(8932):1307.
1994: Shin R W; Lee V M; Trojanowski J Q
Aluminum modifies the properties of Alzheimer's disease PHF tau proteins in vivo and in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(11 Pt 2):7221-33.
1994: Matsuo E S; Shin R W; Billingsley M L; Van deVoorde A; O'Connor M; Trojanowski J Q; Lee V M
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.
Neuron 1994;13(4):989-1002.
1994: Arai H; Muramatsu T; Higuchi S; Sasaki H; Trojanowski J Q
Apolipoprotein E gene in Parkinson's disease with or without dementia.
Lancet 1994;344(8926):889.
1994: Molenaar W M; Trojanowski J Q
Primitive neuroectodermal tumors of the central nervous system in childhood: tumor biological aspects.
Critical reviews in oncology/hematology 1994;17(1):1-25.
1994: Springer J E; Mu X; Bergmann L W; Trojanowski J Q
Expression of GDNF mRNA in rat and human nervous tissue.
Experimental neurology 1994;127(2):167-70.
1994: Schmidt M L; DiDario A G; Lee V M; Trojanowski J Q
An extensive network of PHF tau-rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease.
FEBS letters 1994;344(1):69-73.
1994: Arnold S E; Franz B R; Trojanowski J Q
Elderly patients with schizophrenia exhibit infrequent neurodegenerative lesions.
Neurobiology of aging 1994;15(3):299-303.
1994: Arai H; Higuchi S; Matsushita S; Yuzuriha T; Trojanowski J Q; Lee V M
Expression of beta-amyloid precursor protein in the developing human spinal cord.
Brain research 1994;642(1-2):132-6.
1994: Billingsley M L; Ellis C; Kincaid R L; Martin J; Schmidt M L; Lee V M; Trojanowski J Q
Calcineurin immunoreactivity in Alzheimer's disease.
Experimental neurology 1994;126(2):178-84.
1994: Trojanowski J Q; Lee V M
Paired helical filament tau in Alzheimer's disease. The kinase connection.
The American journal of pathology 1994;144(3):449-53.
1994: Bickel U; Lee V M; Trojanowski J Q; Pardridge W M
Development and in vitro characterization of a cationized monoclonal antibody against beta A4 protein: a potential probe for Alzheimer's disease.
Bioconjugate chemistry 1994;5(2):119-25.
1994: Trojanowski J Q; Fung K M; Rorke L B; Tohyama T; Yachnis A T; Lee V M
In vivo and in vitro models of medulloblastomas and other primitive neuroectodermal brain tumors of childhood.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1994;21(2-3):219-39.
1994: Yachnis A T; Rorke L B; Trojanowski J Q
Cerebellar dysplasias in humans: development and possible relationship to glial and primitive neuroectodermal tumors of the cerebellar vermis.
Journal of neuropathology and experimental neurology 1994;53(1):61-71.
1994: Li Y T; Woodruff-Pak D S; Trojanowski J Q
Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites.
Neurobiology of aging 1994;15(1):1-9.
1994: Fung K M; Chikaraishi D M; Suri C; Theuring F; Messing A; Albert D M; Lee V M; Trojanowski J Q
Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice.
Laboratory investigation; a journal of technical methods and pathology 1994;70(1):114-24.
1994: Dickson D W; Schmidt M L; Lee V M; Zhao M L; Yen S H; Trojanowski J Q
Immunoreactivity profile of hippocampal CA2/3 neurites in diffuse Lewy body disease.
Acta neuropathologica 1994;87(3):269-76.
1994: Lee V M; Daughenbaugh R; Trojanowski J Q
Microtubule stabilizing drugs for the treatment of Alzheimer's disease.
Neurobiology of aging 1994;15 Suppl 2():S87-9.
1993: Wertkin A M; Turner R S; Pleasure S J; Golde T E; Younkin S G; Trojanowski J Q; Lee V M
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9513-7.
1993: Trojanowski J Q; Mantione J R; Lee J H; Seid D P; You T; Inge L J; Lee V M
Neurons derived from a human teratocarcinoma cell line establish molecular and structural polarity following transplantation into the rodent brain.
Experimental neurology 1993;122(2):283-94.
1993: Trojanowski J Q; Mawal-Dewan M; Schmidt M L; Martin J; Lee V M
Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.
Brain research 1993;618(2):333-7.
1993: Yachnis A T; Rorke L B; Lee V M; Trojanowski J Q
Expression of neuronal and glial polypeptides during histogenesis of the human cerebellar cortex including observations on the dentate nucleus.
The Journal of comparative neurology 1993;334(3):356-69.
1993: Shin R W; Bramblett G T; Lee V M; Trojanowski J Q
Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6825-8.
1993: Tagliavini F; Giaccone G; Prelli F; Verga L; Porro M; Trojanowski J Q; Farlow M R; Frangione B; Ghetti B; Bugiani O
A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred.
Brain research 1993;616(1-2):325-9.
1993: Lanza D C; Moran D T; Doty R L; Trojanowski J Q; Lee J H; Rowley J C; Crawford D; Kennedy D W
Endoscopic human olfactory biopsy technique: a preliminary report.
The Laryngoscope 1993;103(7):815-9.
1993: Tohyama T; Lee V M; Rorke L B; Marvin M; McKay R D; Trojanowski J Q
Monoclonal antibodies to a rat nestin fusion protein recognize a 220-kDa polypeptide in subsets of fetal and adult human central nervous system neurons and in primitive neuroectodermal tumor cells.
The American journal of pathology 1993;143(1):258-68.
1993: Goedert M; Jakes R; Crowther R A; Six J; Lübke U; Vandermeeren M; Cras P; Trojanowski J Q; Lee V M
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5066-70.
1993: Bramblett G T; Goedert M; Jakes R; Merrick S E; Trojanowski J Q; Lee V M
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
Neuron 1993;10(6):1089-99.
1993: Lee J H; Goedert M; Hill W D; Lee V M; Trojanowski J Q
Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord.
Experimental neurology 1993;121(1):93-105.
1993: Schmidt M L; Murray J M; Trojanowski J Q
Continuity of neuropil threads with tangle-bearing and tangle-free neurons in Alzheimer disease cortex. A confocal laser scanning microscopy study.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1993;18(3):299-312.
1993: Hill W D; Arai M; Cohen J A; Trojanowski J Q
Neurofilament mRNA is reduced in Parkinson's disease substantia nigra pars compacta neurons.
The Journal of comparative neurology 1993;329(3):328-36.
1993: Tlhyama T; Lee V M; Trojanowski J Q
Co-expression of low molecular weight neurofilament protein and glial fibrillary acidic protein in established human glioma cell lines.
The American journal of pathology 1993;142(3):883-92.
1993: Trojanowski J Q; Schmidt M L; Shin R W; Bramblett G T; Rao D; Lee V M
Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias.
Brain pathology (Zurich, Switzerland) 1993;3(1):45-54.
1992: Lee V M; Trojanowski J Q
The disordered neuronal cytoskeleton in Alzheimer's disease.
Current opinion in neurobiology 1992;2(5):653-6.
1992: Trojanowski J Q; Tohyama T; Lee V M
Medulloblastomas and related primitive neuroectodermal brain tumors of childhood recapitulate molecular milestones in the maturation of neuroblasts.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1992;17(2):121-35.
1992: Fung K M; Messing A; Lee V M; Trojanowski J Q
A novel modification of the avidin-biotin complex method for immunohistochemical studies of transgenic mice with murine monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(9):1319-28.
1992: Luider T M; van Dommelen M W; Tibboel D; Meijers J H; Ten Kate F J; Trojanowski J Q; Molenaar J C
Differences in phosphorylation state of neurofilament proteins in ganglionic and aganglionic bowel segments of children with Hirschsprung's disease.
Journal of pediatric surgery 1992;27(7):815-9.
1992: Arai H; Lee V M; Hill W D; Greenberg B D; Trojanowski J Q
Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease.
Brain research 1992;585(1-2):386-90.
1992: Arai H; Schmidt M L; Lee V M; Hurtig H I; Greenberg B D; Adler C H; Trojanowski J Q
Epitope analysis of senile plaque components in the hippocampus of patients with Parkinson's disease.
Neurology 1992;42(7):1315-22.
1992: Erickson J D; Lloyd R; Trojanowski J Q; Iacangelo A; Eiden E
Sites of synthesis of chromogranins A and B in the human brain.
Neuropeptides 1992;21(4):239-44.
1992: Tohyama T; Lee V M; Rorke L B; Marvin M; McKay R D; Trojanowski J Q
Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):303-13.
1992: Bramblett G T; Trojanowski J Q; Lee V M
Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).
Laboratory investigation; a journal of technical methods and pathology 1992;66(2):212-22.
1992: Itoh T; Sobue G; Ken E; Mitsuma T; Takahashi A; Trojanowski J Q
Phosphorylated high molecular weight neurofilament protein in the peripheral motor, sensory and sympathetic neuronal perikarya: system-dependent normal variations and changes in amyotrophic lateral sclerosis and multiple system atrophy.
Acta neuropathologica 1992;83(3):240-5.
1991: Arnold S E; Lee V M; Gur R E; Trojanowski J Q
Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10850-4.
1991: Arai H; Lee V M; Messinger M L; Greenberg B D; Lowery D E; Trojanowski J Q
Expression patterns of beta-amyloid precursor protein (beta-APP) in neural and nonneural human tissues from Alzheimer's disease and control subjects.
Annals of neurology 1991;30(5):686-93.
1991: Standaert D G; Lee V M; Greenberg B D; Lowery D E; Trojanowski J Q
Molecular features of hypothalamic plaques in Alzheimer's disease.
The American journal of pathology 1991;139(3):681-91.
1991: Tohyama T; Lee V M; Rorke L B; Trojanowski J Q
Molecular milestones that signal axonal maturation and the commitment of human spinal cord precursor cells to the neuronal or glial phenotype in development.
The Journal of comparative neurology 1991;310(3):285-99.
1991: Trojanowski J Q; Newman P D; Hill W D; Lee V M
Human olfactory epithelium in normal aging, Alzheimer's disease, and other neurodegenerative disorders.
The Journal of comparative neurology 1991;310(3):365-76.
1991: Balin B J; Clark E A; Trojanowski J Q; Lee V M
Neurofilament reassembly in vitro: biochemical, morphological and immuno-electron microscopic studies employing monoclonal antibodies to defined epitopes.
Brain research 1991;556(2):181-95.
1991: Hill W D; Lee V M; Hurtig H I; Murray J M; Trojanowski J Q
Epitopes located in spatially separate domains of each neurofilament subunit are present in Parkinson's disease Lewy bodies.
The Journal of comparative neurology 1991;309(1):150-60.
1991: Schmidt M L; Murray J; Lee V M; Hill W D; Wertkin A; Trojanowski J Q
Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies.
The American journal of pathology 1991;139(1):53-65.
1991: Baker D L; Molenaar W M; Trojanowski J Q; Evans A E; Ross A H; Rorke L B; Packer R J; Lee V M; Pleasure D
Nerve growth factor receptor expression in peripheral and central neuroectodermal tumors, other pediatric brain tumors, and during development of the adrenal gland.
The American journal of pathology 1991;139(1):115-22.
1991: He X M; Wikstrand C J; Friedman H S; Bigner S H; Pleasure S; Trojanowski J Q; Bigner D D
Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.
Laboratory investigation; a journal of technical methods and pathology 1991;64(6):833-43.
1991: Erickson J D; Trojanowski J Q; Eiden L E
Regional distribution and partial molecular characterization of CD4-related mRNA in human brain and peripheral tissues.
Brain research. Molecular brain research 1991;10(1):23-31.
1991: Schmidt M L; Lee V M; Trojanowski J Q
Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads.
Laboratory investigation; a journal of technical methods and pathology 1991;64(3):352-7.
1991: Lee V M; Balin B J; Otvos L; Trojanowski J Q
A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.
Science (New York, N.Y.) 1991;251(4994):675-8.
1991: Clark E A; Leach K L; Trojanowski J Q; Lee V M
Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains.
Laboratory investigation; a journal of technical methods and pathology 1991;64(1):35-44.
1991: Trojanowski J Q; Molenaar W M; Baker D L; Pleasure D; Lee V M
Neural and neuroendocrine phenotype of neuroblastomas, ganglioneuroblastomas, ganglioneuromas and mature versus embryonic human adrenal medullary cells.
Progress in clinical and biological research 1991;366():335-41.
1991: Molenaar W M; de Leij L; Trojanowski J Q
Neuroectodermal tumors of the peripheral and the central nervous system share neuroendocrine N-CAM-related antigens with small cell lung carcinomas.
Acta neuropathologica 1991;83(1):46-54.
1990: Pleasure S J; Reddy U R; Venkatakrishnan G; Roy A K; Chen J; Ross A H; Trojanowski J Q; Pleasure D E; Lee V M
Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8496-500.
1990: Wong D H; Ignatius M J; Parosky G; Parham P; Trojanowski J Q; Brodsky F M
Neuron-specific expression of high-molecular-weight clathrin light chain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(9):3025-31.
1990: Visscher D W; Zarbo R J; Trojanowski J Q; Sakr W; Crissman J D
Neuroendocrine differentiation in poorly differentiated lung carcinomas: a light microscopic and immunohistologic study.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1990;3(4):508-12.
1990: Schmidt M L; Lee V M; Trojanowski J Q
Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles.
The American journal of pathology 1990;136(5):1069-75.
1990: Stern R A; Trojanowski J Q; Lee V M
Antibodies to the beta-amyloid peptide cross-react with conformational epitopes in human fibrinogen subunits from peripheral blood.
FEBS letters 1990;264(1):43-7.
1990: Gould V E; Jansson D S; Molenaar W M; Rorke L B; Trojanowski J Q; Lee V M; Packer R J; Franke W W
Primitive neuroectodermal tumors of the central nervous system. Patterns of expression of neuroendocrine markers, and all classes of intermediate filament proteins.
Laboratory investigation; a journal of technical methods and pathology 1990;62(4):498-509.
1990: Molenaar W M; Lee V M; Trojanowski J Q
Early fetal acquisition of the chromaffin and neuronal immunophenotype by human adrenal medullary cells. An immunohistological study using monoclonal antibodies to chromogranin A, synaptophysin, tyrosine hydroxylase, and neuronal cytoskeletal proteins.
Experimental neurology 1990;108(1):1-9.
1990: Gould V E; Rorke L B; Jansson D S; Molenaar W M; Trojanowski J Q; Lee V M; Packer R J; Franke W W
Primitive neuroectodermal tumors of the central nervous system express neuroendocrine markers and may express all classes of intermediate filaments.
Human pathology 1990;21(3):245-52.
1990: Arai H; Lee V M; Otvos L; Greenberg B D; Lowery D E; Sharma S K; Schmidt M L; Trojanowski J Q
Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2249-53.
1990: Perez M A; Saul S H; Trojanowski J Q
Neurofilament and chromogranin expression in normal and neoplastic neuroendocrine cells of the human gastrointestinal tract and pancreas.
Cancer 1990;65(5):1219-27.
1990: Molenaar W M; Baker D L; Pleasure D; Lee V M; Trojanowski J Q
The neuroendocrine and neural profiles of neuroblastomas, ganglioneuroblastomas, and ganglioneuromas.
The American journal of pathology 1990;136(2):375-82.
1990: Sobue G; Hashizume Y; Yasuda T; Mukai E; Kumagai T; Mitsuma T; Trojanowski J Q
Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells.
Acta neuropathologica 1990;79(4):402-8.
1990: Trojanowski J Q; Schmidt M L; Otvos L; Arai H; Hill W D; Lee V M
Vulnerability of the neuronal cytoskeleton in aging and Alzheimer disease: widespread involvement of all three major filament systems.
Annual review of gerontology & geriatrics 1990;10():167-82.
1989: Molenaar W M; Jansson D S; Gould V E; Rorke L B; Franke W W; Lee V M; Packer R J; Trojanowski J Q
Molecular markers of primitive neuroectodermal tumors and other pediatric central nervous system tumors. Monoclonal antibodies to neuronal and glial antigens distinguish subsets of primitive neuroectodermal tumors.
Laboratory investigation; a journal of technical methods and pathology 1989;61(6):635-43.
1989: Frank T S; Trojanowski J Q; Roberts S A; Brooks J J
A detailed immunohistochemical analysis of cerebellar hemangioblastoma: an undifferentiated mesenchymal tumor.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1989;2(6):638-51.
1989: Trojanowski J Q; Kelsten M L; Lee V M
Phosphate-dependent and independent neurofilament protein epitopes are expressed throughout the cell cycle in human medulloblastoma (D283 MED) cells.
The American journal of pathology 1989;135(4):747-58.
1989: Trojanowski J Q; Schuck T; Schmidt M L; Lee V M
Distribution of phosphate-independent MAP2 epitopes revealed with monoclonal antibodies in microwave-denatured human nervous system tissues.
Journal of neuroscience methods 1989;29(2):171-80.
1989: Hurtig H; Joyce J; Sladek J R; Trojanowski J Q
Postmortem analysis of adrenal-medulla-to-caudate autograft in a patient with Parkinson's disease.
Annals of neurology 1989;25(6):607-14.
1989: Stern R A; Otvos L; Trojanowski J Q; Lee V M
Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system.
The American journal of pathology 1989;134(5):973-8.
1989: Schmidt M L; Lee V M; Trojanowski J Q
Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus.
Laboratory investigation; a journal of technical methods and pathology 1989;60(4):513-22.
1989: Trojanowski J Q; Schuck T; Schmidt M L; Lee V M
Distribution of tau proteins in the normal human central and peripheral nervous system.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(2):209-15.
1989: He X M; Skapek S X; Wikstrand C J; Friedman H S; Trojanowski J Q; Kemshead J T; Coakham H B; Bigner S H; Bigner D D
Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts.
Journal of neuropathology and experimental neurology 1989;48(1):48-68.
1989: Brooks J J; Trojanowski J Q; LiVolsi V A
Chondroid chordoma: a low-grade chondrosarcoma and its differential diagnosis.
Current topics in pathology. Ergebnisse der Pathologie 1989;80():165-81.
1989: Trojanowski J Q; Schmidt M L; Otvos L; Gur R C; Gur R E; Hurtig H; Lee V M
Selective expression of epitopes in multiphosphorylation repeats of the high and middle molecular weight neurofilament proteins in Alzheimer neurofibrillary tangles.
Annals of medicine 1989;21(2):113-6.
1988: Kosik K S; Orecchio L D; Binder L; Trojanowski J Q; Lee V M; Lee G
Epitopes that span the tau molecule are shared with paired helical filaments.
Neuron 1988;1(9):817-25.
1988: Lee V M; Otvos L; Schmidt M L; Trojanowski J Q
Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7384-8.
1988: Schmidt M L; Lee V M; Hurtig H; Trojanowski J Q
Properties of antigenic determinants that distinguish neurofibrillary tangles in progressive supranuclear palsy and Alzheimer's disease.
Laboratory investigation; a journal of technical methods and pathology 1988;59(4):460-6.
1988: Braffman B H; Zimmerman R A; Trojanowski J Q; Gonatas N K; Hickey W F; Schlaepfer W W
Brain MR: pathologic correlation with gross and histopathology. 2. Hyperintense white-matter foci in the elderly.
AJR. American journal of roentgenology 1988;151(3):559-66.
1988: Braffman B H; Zimmerman R A; Trojanowski J Q; Gonatas N K; Hickey W F; Schlaepfer W W
Brain MR: pathologic correlation with gross and histopathology. 1. Lacunar infarction and Virchow-Robin spaces.
AJR. American journal of roentgenology 1988;151(3):551-8.
1988: Yachnis A T; Trojanowski J Q; Memmo M; Schlaepfer W W
Expression of neurofilament proteins in the hypertrophic granule cells of Lhermitte-Duclos disease: an explanation for the mass effect and the myelination of parallel fibers in the disease state.
Journal of neuropathology and experimental neurology 1988;47(3):206-16.
1988: Friedman H S; Burger P C; Bigner S H; Trojanowski J Q; Brodeur G M; He X M; Wikstrand C J; Kurtzberg J; Berens M E; Halperin E C
Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.
The American journal of pathology 1988;130(3):472-84.
1988: Schmidt M L; Gur R E; Gur R C; Trojanowski J Q
Intraneuronal and extracellular neurofibrillary tangles exhibit mutually exclusive cytoskeletal antigens.
Annals of neurology 1988;23(2):184-9.
1988: Milstein O; Trojanowski J; Hüttermann A; Gressel J
Catabolism of single ring aromatic acids by four Aspergillus species.
Microbios 1988;55(222):7-16.
1987: Carden M J; Trojanowski J Q; Schlaepfer W W; Lee V M
Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(11):3489-504.
1987: Lee V M; Carden M J; Schlaepfer W W; Trojanowski J Q
Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(11):3474-88.
1987: Christen B; Trojanowski J Q; Pietra G G
Immunohistochemical demonstration of phosphorylated and nonphosphorylated forms of human neurofilament subunits in human pulmonary carcinoids.
Human pathology 1987;18(10):997-1001.
1987: Trojanowski J Q
Neurofilament proteins and human nervous system tumors.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1987;35(9):999-1003.
1987: Kuwayama Y; Terenghi G; Polak J M; Trojanowski J Q; Stone R A
A quantitative correlation of substance P-, calcitonin gene-related peptide- and cholecystokinin-like immunoreactivity with retrogradely labeled trigeminal ganglion cells innervating the eye.
Brain research 1987;405(2):220-6.
1987: Schmidt M L; Carden M J; Lee V M; Trojanowski J Q
Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls.
Laboratory investigation; a journal of technical methods and pathology 1987;56(3):282-94.
1987: Trojanowski J Q; Friedman H S; Burger P C; Bigner D D
A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits.
The American journal of pathology 1987;126(2):358-63.
1987: Brooks J J; LiVolsi V A; Trojanowski J Q
Does chondroid chordoma exist?
Acta neuropathologica 1987;72(3):229-35.
1986: Schmidt M L; Trojanowski J Q
Enzymatic detection of native and derivatized horseradish peroxidase in sodium dodecyl sulfate polyacrylamide gels.
Analytical biochemistry 1986;155(2):371-5.
1986: Trojanowski J Q; Atkinson B; Lee V M
An immunocytochemical study of normal and abnormal human cerebrospinal fluid with monoclonal antibodies to glial fibrillary acidic protein.
Acta cytologica 1986;30(3):235-9.
1986: Lee V M; Carden M J; Trojanowski J Q
Novel monoclonal antibodies provide evidence for the in situ existence of a nonphosphorylated form of the largest neurofilament subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(3):850-8.
1986: Trojanowski J Q; Walkenstein N; Lee V M
Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(3):650-60.
1986: Conrad K A; Gross J L; Trojanowski J Q
Leptomeningeal carcinomatosis presenting as eosinophilic meningitis.
Acta cytologica 1986;30(1):29-31.
1985: Friedman H S; Burger P C; Bigner S H; Trojanowski J Q; Wikstrand C J; Halperin E C; Bigner D D
Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.
Journal of neuropathology and experimental neurology 1985;44(6):592-605.
1985: Dietzschold B; Wiktor T J; Trojanowski J Q; Macfarlan R I; Wunner W H; Torres-Anjel M J; Koprowski H
Differences in cell-to-cell spread of pathogenic and apathogenic rabies virus in vivo and in vitro.
Journal of virology 1985;56(1):12-8.
1985: Schmidt M L; Trojanowski J Q
Immunoblot analysis of horseradish peroxidase conjugates of wheat germ agglutinin before and after retrograde transport in the rat peripheral nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(10):2779-85.
1985: Trojanowski J Q; Stone R A; Lee V M
Presence of an alpha-melanocyte-stimulating hormone-like epitope in the 150,000 dalton neurofilament subunit from diverse regions of the central nervous system: an immunohistochemical and immunoblot study in guinea pig.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1985;33(9):900-4.
1985: Nolan J A; Trojanowski J Q; Hogue-Angeletti R
Neurons and neuroendocrine cells contain chromogranin: detection of the molecule in normal bovine tissues by immunochemical and immunohistochemical methods.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1985;33(8):791-8.
1985: Leff E L; Brooks J S; Trojanowski J Q
Expression of neurofilament and neuron-specific enolase in small cell tumors of skin using immunohistochemistry.
Cancer 1985;56(3):625-31.
1985: Trojanowski J Q; Lee V M
Expression of neurofilament antigens by normal and neoplastic human adrenal chromaffin cells.
The New England journal of medicine 1985;313(2):101-4.
1985: Trojanowski J Q; Obrocka M A; Lee V M
Distribution of neurofilament subunits in neurons and neuronal processes: immunohistochemical studies of bovine cerebellum with subunit-specific monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1985;33(6):557-63.
1985: Schmidt M L; Lee V M; Trojanowski J Q
Immunochemical detection of diverse molecular species of horseradish peroxidase recovered from rat superior cervical ganglion following retrograde transport.
Brain research 1985;328(1):65-72.
1985: Hacker G W; Polak J M; Springall D R; Ballesta J; Cadieux A; Gu J; Trojanowski J Q; Dahl D; Marangos P J
Antibodies to neurofilament protein and other brain proteins reveal the innervation of peripheral organs.
Histochemistry 1985;82(6):581-93.
1985: Tremblay G F; Lee V M; Trojanowski J Q
Expression of vimentin, glial filament, and neurofilament proteins in primitive childhood brain tumors. A comparative immunoblot and immunoperoxidase study.
Acta neuropathologica 1985;68(3):239-44.
1985: Bishop A E; Carlei F; Lee V; Trojanowski J; Marangos P J; Dahl D; Polak J M
Combined immunostaining of neurofilaments, neuron specific enolase, GFAP and S-100. A possible means for assessing the morphological and functional status of the enteric nervous system.
Histochemistry 1985;82(1):93-7.
1985: Angeletti R H; Trojanowski J Q; Carden M; Schlaepfer W W; Lee V M
Domain structure of neurofilament subunits as revealed by monoclonal antibodies.
Journal of cellular biochemistry 1985;27(2):181-7.
1984: Trojanowski J Q; Schmidt M L
Interneuronal transfer of axonally transported proteins: studies with HRP and HRP conjugates of wheat germ agglutinin, cholera toxin and the B subunit of cholera toxin.
Brain research 1984;311(2):366-9.
1984: Schlaepfer W W; Lee C; Trojanowski J Q; Lee V M
Persistence of immunoreactive neurofilament protein breakdown products in transected rat sciatic nerve.
Journal of neurochemistry 1984;43(3):857-64.
1984: Trojanowski J Q; Lee V M; Schlaepfer W W
Neurofilament breakdown products in degenerating rat and human peripheral nerves.
Annals of neurology 1984;16(3):349-55.
1984: Trojanowski J Q; Hickey W F
Human teratomas express differentiated neural antigens. An immunohistochemical study with anti-neurofilament, anti-glial filament, and anti-myelin basic protein monoclonal antibodies.
The American journal of pathology 1984;115(3):383-9.
1984: Trojanowski J Q; Gordon D; Obrocka M; Lee V M
The developmental expression of neurofilament and glial filament proteins in the human pituitary gland: an immunohistochemical study with monoclonal antibodies.
Brain research 1984;315(2):229-39.
1984: Trojanowski J Q; Lee V M; Schlaepfer W W
An immunohistochemical study of human central and peripheral nervous system tumors, using monoclonal antibodies against neurofilaments and glial filaments.
Human pathology 1984;15(3):248-57.
1983: Trojanowski J Q
Native and derivatized lectins for in vivo studies of neuronal connectivity and neuronal cell biology.
Journal of neuroscience methods 1983;9(3):185-204.
1983: Trojanowski J Q; Obrocka M A; Lee V M
A comparison of eight different chromogen protocols for the demonstration of immunoreactive neurofilaments or glial filaments in rat cerebellum using the peroxidase-antiperoxidase method and monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1983;31(10):1217-23.
1983: Hickey W F; Lee V; Trojanowski J Q; McMillan L J; McKearn T J; Gonatas J; Gonatas N K
Immunohistochemical application of monoclonal antibodies against myelin basic protein and neurofilament triple protein subunits: advantages over antisera and technical limitations.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1983;31(9):1126-35.
1983: Trojanowski J Q; Gonatas N K
A morphometric study of the endocytosis of wheat germ agglutinin-horseradish peroxidase conjugates by retinal ganglion cells in the rat.
Brain research 1983;272(2):201-10.
1983: Trojanowski J Q
Time of arrival of wheat germ agglutinin-HRP conjugates in superior colliculus after intraocular injections in the rat.
Brain research 1983;267(2):365-70.
1983: Trojanowski J Q; Lee V M
Monoclonal and polyclonal antibodies against neural antigens: diagnostic applications for studies of central and peripheral nervous system tumors.
Human pathology 1983;14(4):281-5.
1983: Trojanowski J Q; Lee V M
Anti-neurofilament monoclonal antibodies: reagents for the evaluation of human neoplasms.
Acta neuropathologica 1983;59(2):155-8.
1982: Trojanowski J Q; Tascos N A; Rorke L B
Malignant pineocytoma with prominent papillary features.
Cancer 1982;50(9):1789-93.
1982: Wan X S; Trojanowski J Q; Gonatas J O; Liu C N
Cytoarchitecture of the extranuclear and commissural dendrites of hypoglossal nucleus neurons as revealed by conjugates of horseradish peroxidase with cholera toxin.
Experimental neurology 1982;78(1):167-75.
1982: Trojanowski J Q; Lee V; Pillsbury N; Lee S
Neuronal origin of human esthesioneuroblastoma demonstrated with anti-neurofilament monoclonal antibodies.
The New England journal of medicine 1982;307(3):159-61.
1982: Wan X C; Trojanowski J Q; Gonatas J O
Cholera toxin and wheat germ agglutinin conjugates as neuroanatomical probes: their uptake and clearance, transganglionic and retrograde transport and sensitivity.
Brain research 1982;243(2):215-24.
1982: Lee V; Trojanowski J Q; Schlaepfer W W
Induction of neurofilament triplet proteins in PC12 cells by nerve growth factor.
Brain research 1982;238(1):169-80.
1982: Trojanowski J Q; Gonatas J O; Gonatas N K
Horseradish peroxidase (HRP) conjugates of cholera toxin and lectins are more sensitive retrogradely transported markers than free HRP.
Brain research 1982;231(1):33-50.
1981: Trojanowski J Q; Gonatas J O; Gonatas N K
Conjugates of horseradish peroxidase (HRP) with cholera toxin and wheat germ agglutinin are superior to free HRP as orthogradely transported markers.
Brain research 1981;223(2):381-5.
1981: Trojanowski J Q; Lafontaine M H
Neuroanatomical correlates of selective downgaze paralysis.
Journal of the neurological sciences 1981;52(1):91-101.
1981: Trojanowski J Q; Gonatas J O; Gonatas N K
A light and electron microscopic study of the intraneuronal transport of horseradish peroxidase and wheat germ agglutinin-peroxidase conjugates in the rat visual system.
Journal of neurocytology 1981;10(3):441-56.
1981: Trojanowski J Q; Gang D L; Goldblatt A; Akins C W
Fatal postoperative acute appendicitis in a neonate with congenital heart disease.
Journal of pediatric surgery 1981;16(1):85-6.
1980: Trojanowski J Q; Kleinman G M; Proppe K H
Malignant tumors of nerve sheath origin.
Cancer 1980;46(5):1202-12.
1980: Trojanowski J Q; Green R C; Levine D N
Crossed aphasia in a dextral: a clinicopathological study.
Neurology 1980;30(7 Pt 1):709-13.
1980: Trojanowski J Q; Wray S H
Vertical gaze ophthalmoplegia: selective paralysis of downgaze.
Neurology 1980;30(6):605-10.
1980: Trojanowski J Q; Harrist T J; Athanasoulis C A; Greenfield A J
Hepatic and splenic infarctions: complications of therapeutic transcatheter embolization.
American journal of surgery 1980;139(2):272-7.
1977: Jacobson S; Trojanowski J Q
Prefrontal granular cortex of the rhesus monkey. II. Interhemispheric cortical afferents.
Brain research 1977;132(2):235-46.
1977: Jacobson S; Trojanowski J Q
Prefrontal granular cortex of the rhesus monkey. I. Intrahemispheric cortical afferents.
Brain research 1977;132(2):209-33.
1977: Trojanowski J Q; Jacobson S
The morphology and laminar distribution of cortico-pulvinar neurons in the rhesus monkey.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1977;28(1-2):51-62.
1976: Trojanowski J Q; Jacobson S
Areal and laminar distribution of some pulvinar cortical efferents in rhesus monkey.
The Journal of comparative neurology 1976;169(3):371-92.
1975: Jacobson S; Trojanowski J Q
Amygdaloid projections to prefrontal granular cortex in rhesus monkey demonstrated with horseradish peroxidase.
Brain research 1975;100(1):132-9.
1975: Jacobson S; Trojanowski J Q
Corticothalamic neurons and thalamocortical terminal fields: an investigation in rat using horseradish peroxidase and autoradiography.
Brain research 1975;85(3):385-401.
1975: Trojanowski J Q; Jacobson S
A combined horseradish peroxidase-autoradiographic investigation of reciprocal connections between superior temporal gyrus and pulvinar in squirrel monkey.
Brain research 1975;85(2):347-53.
1975: Jacobson S; Trojanowski J Q
The appearance of dendrites of callosal and corticothalamic neurons in somatosensory cortex of immature rats demonstrated by horseradish peroxidase.
Advances in neurology 1975;12():319-33.
1974: Trojanowski J Q; Jacobson S
Medial pulvinar afferents to frontal eye fields in rhesus monkey demonstrated by horseradish peroxidase.
Brain research 1974;80(3):395-411.
1974: Jacobson S; Trojanowski J Q
The cells of origin of the corpus callosum in rat, cat and rhesus monkey.
Brain research 1974;74(1):149-55.

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