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Armelle Troussard

Research Profile

Chemicals & Drugs

Physiology

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Breast Neoplasms

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Publications

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Armelle A Troussard; Paul C McDonald; Elizabeth D Wederell; Nasrin M Mawji; Nolan R Filipenko; Karen Gelmon; Jill E Kucab; Sandra E Dunn; Joanne T Emerman; Marcel B Bally; Shoukat Dedhar
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival.
Gregory E Hannigan; Armelle A Troussard; Shoukat Dedhar
Integrin-linked kinase: a cancer therapeutic target unique among its ILK.
Lianne M McHardy; Ryan Sinotte; Armelle A Troussard; Claire Sheldon; John Church; David E Williams; Raymond J Andersen; Shoukat Dedhar; Michel Roberge; Calvin D Roskelley
The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange.

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All Publications

2006: Armelle A Troussard; Paul C McDonald; Elizabeth D Wederell; Nasrin M Mawji; Nolan R Filipenko; Karen Gelmon; Jill E Kucab; Sandra E Dunn; Joanne T Emerman; Marcel B Bally; Shoukat Dedhar
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival.
Cancer research 2006;66(1):393-403.
2005: Gregory E Hannigan; Armelle A Troussard; Shoukat Dedhar
Integrin-linked kinase: a cancer therapeutic target unique among its ILK.
Nature reviews. Cancer 2005;5(1):51-63.
2004: Lianne M McHardy; Ryan Sinotte; Armelle A Troussard; Claire Sheldon; John Church; David E Williams; Raymond J Andersen; Shoukat Dedhar; Michel Roberge; Calvin D Roskelley
The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange.
Cancer research 2004;64(4):1468-74.
2004: Clara Tan; Séverine Cruet-Hennequart; Armelle A Troussard; Ladan Fazli; Penny Costello; Kym Sutton; Jeff Wheeler; Martin Gleave; Jasbinder S Sanghera; Shoukat Dedhar
Regulation of tumor angiogenesis by integrin-linked kinase (ILK).
Cancer cell 2004;5(1):79-90.
2003: Sarah Attwell; Julia Mills; Armelle A Troussard; Chuanyue Wu; Shoukat Dedhar
Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.
Molecular biology of the cell 2003;14(12):4813-25.
2003: Armelle A Troussard; Nasrin M Mawji; Christopher Ong; Alice L-F Mui; René St Arnaud; Shoukat Dedhar
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.
The Journal of biological chemistry 2003;278(25):22374-8.
2001: Calvin D Roskelley; David E Williams; Lianne M McHardy; Kevin G Leong; Armelle A Troussard; Aly Karsan; Raymond J Andersen; Shoukat Dedhar; Michel Roberge
Inhibition of tumor cell invasion and angiogenesis by motuporamines.
Cancer research 2001;61(18):6788-94.
2001: Sujata Persad; Armelle A Troussard; T R McPhee; D J Mulholland; Shoukat Dedhar
Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation.
The Journal of cell biology 2001;153(6):1161-74.
2000: Armelle A Troussard; Penny Costello; TN Yoganathan; S Kumagai; C D Roskelley; Shoukat Dedhar
The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9).
Oncogene 2000;19(48):5444-52.
2000: Mark D'Amico; James Hulit; DF Amanatullah; Brian T Zafonte; Chris Albanese; Boumediene Bouzahzah; Maofu Fu; Leonard H Augenlicht; L A Donehower; K Takemaru; Randall T Moon; R Davis; Michael P Lisanti; Michael Shtutman; Jacob Zhurinsky; Avri Ben-Ze'ev; Armelle A Troussard; Shoukat Dedhar; Richard G Pestell
The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.
The Journal of biological chemistry 2000;275(42):32649-57.
2000: Sujata Persad; Sarah Attwell; Virginia Gray; M Delcommenne; Armelle A Troussard; Jasbinder S Sanghera; Shoukat Dedhar
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3207-12.
1999: Armelle A Troussard; Clara Tan; TN Yoganathan; Shoukat Dedhar
Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner.
Molecular and cellular biology 1999;19(11):7420-7.