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Kathleen Trybus

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TOP 3
Bipasha Barua; Patricia M Fagnant; Kathleen M Trybus; Donald A Winkelmann; Sarah E Hitchcock-DeGregori
A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin.
Kathleen M Trybus; Vladimir I Gelfand
Molecular motors.
M Yusuf Ali; Samantha B Previs; H Lee Sweeney; Kathleen M Trybus; David M Warshaw
Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection.

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All Publications

2013: Bipasha Barua; Patricia M Fagnant; Kathleen M Trybus; Donald A Winkelmann; Sarah E Hitchcock-DeGregori
A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin.
The Journal of biological chemistry 2013;288(14):9602-9.
2013: Kathleen M Trybus; Vladimir I Gelfand
Molecular motors.
Molecular biology of the cell 2013;24(6):672.
2013: M Yusuf Ali; Samantha B Previs; H Lee Sweeney; Kathleen M Trybus; David M Warshaw
Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection.
Traffic (Copenhagen, Denmark) 2013;14(1):70-81.
2012: Hailong Lu; Kathleen M Trybus; Carol S Bookwalter; Jonathan W Driver; Artem K Efremov; Elena B Krementsova; Michael R Diehl
Collective dynamics of elastically coupled myosin V motors.
The Journal of biological chemistry 2012;287(33):27753-61.
2012: Alex R Hodges; Elena B Krementsova; Thomas E Sladewski; Carol S Bookwalter; Patricia M Fagnant; Kathleen M Trybus
Tropomyosin is essential for processive movement of a class V myosin from budding yeast.
Current biology : CB 2012;22(15):1410-6.
2012: Jessica M Armstrong; Aoife T Heaslip; Elena B Krementsova; Arthur J Michalek; Shane R Nelson; Kathleen M Trybus; David M Warshaw
Full-length myosin Va exhibits altered gating during processive movement on actin.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):E218-24.
2011: Elena B Krementsova; Thomas E Sladewski; H Lee Sweeney; Mirko Travaglia; Carol S Bookwalter; Alex R Hodges; Kathleen M Trybus
Two single-headed myosin V motors bound to a tetrameric adapter protein form a processive complex.
The Journal of cell biology 2011;195(4):631-41.
2011: M Yusuf Ali; Guy G Kennedy; Daniel Safer; H Lee Sweeney; Kathleen M Trybus; David M Warshaw
Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):E535-41.
2010: Hailong Lu; Guy G Kennedy; David M Warshaw; Kathleen M Trybus
Simultaneous observation of tail and head movements of myosin V during processive motion.
The Journal of biological chemistry 2010;285(53):42068-74.
2010: Susan Lowey; Kathleen M Trybus
Common structural motifs for the regulation of divergent class II myosins.
The Journal of biological chemistry 2010;285(22):16403-7.
2010: Edward P Debold; Walid Saber; Yaser Cheema; Carol S Bookwalter; Kathleen M Trybus; David M Warshaw; Peter VanBuren
Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro.
Journal of molecular and cellular cardiology 2010;48(2):286-92.
2009: Alex R Hodges; Carol S Bookwalter; Elena B Krementsova; Kathleen M Trybus
A nonprocessive class V myosin drives cargo processively when a kinesin- related protein is a passenger.
Current biology : CB 2009;19(24):2121-5.
2009: Hailong Lu; M Yusuf Ali; Carol S Bookwalter; David M Warshaw; Kathleen M Trybus
Diffusive movement of processive kinesin-1 on microtubules.
Traffic (Copenhagen, Denmark) 2009;10(10):1429-38.
2009: Shane R Nelson; M Yusuf Ali; Kathleen M Trybus; David M Warshaw
Random walk of processive, quantum dot-labeled myosin Va molecules within the actin cortex of COS-7 cells.
Biophysical journal 2009;97(2):509-18.
2009: Sam Walcott; Patricia M Fagnant; Kathleen M Trybus; David M Warshaw
Smooth muscle heavy meromyosin phosphorylated on one of its two heads supports force and motion.
The Journal of biological chemistry 2009;284(27):18244-51.
2009: Carol S Bookwalter; Matthew Lord; Kathleen M Trybus
Essential features of the class V myosin from budding yeast for ASH1 mRNA transport.
Molecular biology of the cell 2009;20(14):3414-21.
2008: Usha B Nair; Peteranne B Joel; Qun Wan; Susan Lowey; Mark A Rould; Kathleen M Trybus
Crystal structures of monomeric actin bound to cytochalasin D.
Journal of molecular biology 2008;384(4):848-64.
2008: Becky M Miller; Kathleen M Trybus
Functional effects of nemaline myopathy mutations on human skeletal alpha-actin.
The Journal of biological chemistry 2008;283(28):19379-88.
2008: Neil M Kad; Kathleen M Trybus; David M Warshaw
Load and Pi control flux through the branched kinetic cycle of myosin V.
The Journal of biological chemistry 2008;283(25):17477-84.
2008: M Yusuf Ali; Hailong Lu; Carol S Bookwalter; David M Warshaw; Kathleen M Trybus
Myosin V and Kinesin act as tethers to enhance each others' processivity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4691-6.
2008: Alex R Hodges; Elena B Krementsova; Kathleen M Trybus
She3p binds to the rod of yeast myosin V and prevents it from dimerizing, forming a single-headed motor complex.
The Journal of biological chemistry 2008;283(11):6906-14.
2008: Hans Matsson; Jacqueline Eason; Carol S Bookwalter; Joakim Klar; Peter Gustavsson; Jan Sunnegårdh; Henrik Enell; Anders Jonzon; Miikka Vikkula; Ilse Gutierrez; Javier Granados-Riveron; Mark Pope; Frances Bu'Lock; Jane Cox; Thelma E Robinson; Feifei Song; David J Brook; Steven Marston; Kathleen M Trybus; Niklas Dahl
Alpha-cardiac actin mutations produce atrial septal defects.
Human molecular genetics 2008;17(2):256-65.
2007: Alex R Hodges; Elena B Krementsova; Kathleen M Trybus
Engineering the processive run length of Myosin V.
The Journal of biological chemistry 2007;282(37):27192-7.
2007: Kathleen M Trybus; Marina I Gushchin; HongJun Lui; Larnele Hazelwood; Elena B Krementsova; Niels Volkmann; Dorit Hanein
Effect of calcium on calmodulin bound to the IQ motifs of myosin V.
The Journal of biological chemistry 2007;282(32):23316-25.
2007: M Yusuf Ali; Elena B Krementsova; Guy G Kennedy; Rachel Mahaffy; Thomas D Pollard; Kathleen M Trybus; David M Warshaw
Myosin Va maneuvers through actin intersections and diffuses along microtubules.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4332-6.
2007: Neil M Kad; Joseph B Patlak; Patricia M Fagnant; Kathleen M Trybus; David M Warshaw
Mutation of a conserved glycine in the SH1-SH2 helix affects the load-dependent kinetics of myosin.
Biophysical journal 2007;92(5):1623-31.
2007: Niels Volkmann; Hongjun Lui; Larnele Hazelwood; Kathleen M Trybus; Susan Lowey; Dorit Hanein
The R403Q myosin mutation implicated in familial hypertrophic cardiomyopathy causes disorder at the actomyosin interface.
PloS one 2007;2(11):e1123.
2006: Anne Houdusse; Jean-François Gaucher; Elena B Krementsova; Suet Mui; Kathleen M Trybus; Carolyn Cohen
Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19326-31.
2006: Mark A Rould; Qun Wan; Peteranne B Joel; Susan Lowey; Kathleen M Trybus
Crystal structures of expressed non-polymerizable monomeric actin in the ADP and ATP states.
The Journal of biological chemistry 2006;281(42):31909-19.
2006: Hailong Lu; Elena B Krementsova; Kathleen M Trybus
Regulation of myosin V processivity by calcium at the single molecule level.
The Journal of biological chemistry 2006;281(42):31987-94.
2006: Jun Liu; Dianne W Taylor; Elena B Krementsova; Kathleen M Trybus; Kenneth A Taylor
Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography.
Nature 2006;442(7099):208-11.
2006: Carol S Bookwalter; Kathleen M Trybus
Functional consequences of a mutation in an expressed human alpha-cardiac actin at a site implicated in familial hypertrophic cardiomyopathy.
The Journal of biological chemistry 2006;281(24):16777-84.
2006: Arthur S Rovner; Patricia M Fagnant; Kathleen M Trybus
Phosphorylation of a single head of smooth muscle myosin activates the whole molecule.
Biochemistry 2006;45(16):5280-9.
2006: Elena B Krementsova; Alex R Hodges; Hailong Lu; Kathleen M Trybus
Processivity of chimeric class V myosins.
The Journal of biological chemistry 2006;281(9):6079-86.
2005: Niels Volkmann; HongJun Liu; Larnele Hazelwood; Elena B Krementsova; Susan Lowey; Kathleen M Trybus; Dorit Hanein
The structural basis of myosin V processive movement as revealed by electron cryomicroscopy.
Molecular cell 2005;19(5):595-605.
2005: Kathleen M Trybus
No strain, no gain.
Nature cell biology 2005;7(9):854-6.
2005: David M Warshaw; Guy G Kennedy; Steven S Work; Elena B Krementsova; Samantha Beck; Kathleen M Trybus
Differential labeling of myosin V heads with quantum dots allows direct visualization of hand-over-hand processivity.
Biophysical journal 2005;88(5):L30-2.
2004: Peteranne B Joel; Patricia M Fagnant; Kathleen M Trybus
Expression of a nonpolymerizable actin mutant in Sf9 cells.
Biochemistry 2004;43(36):11554-9.
2004: Josh E Baker; Elena B Krementsova; Guy G Kennedy; Amy Armstrong; Kathleen M Trybus; David M Warshaw
Myosin V processivity: multiple kinetic pathways for head-to-head coordination.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5542-6.
2004: Dimitry N Krementsov; Elena B Krementsova; Kathleen M Trybus
Myosin V: regulation by calcium, calmodulin, and the tail domain.
The Journal of cell biology 2004;164(6):877-86.
2004: Jeffrey R Moore; Elena B Krementsova; Kathleen M Trybus; David M Warshaw
Does the myosin V neck region act as a lever?
Journal of muscle research and cell motility 2004;25(1):29-35.
2003: Peteranne B Joel; H Lee Sweeney; Kathleen M Trybus
Addition of lysines to the 50/20 kDa junction of myosin strengthens weak binding to actin without affecting the maximum ATPase activity.
Biochemistry 2003;42(30):9160-6.
2003: Neil M Kad; Arthur S Rovner; Patricia M Fagnant; Peteranne B Joel; Guy G Kennedy; Joseph B Patlak; David M Warshaw; Kathleen M Trybus
A mutant heterodimeric myosin with one inactive head generates maximal displacement.
The Journal of cell biology 2003;162(3):481-8.
2003: Arthur S Rovner; Patricia M Fagnant; Kathleen M Trybus
The two heads of smooth muscle myosin are enzymatically independent but mechanically interactive.
The Journal of biological chemistry 2003;278(29):26938-45.
2003: Niels Volkmann; Greta Ouyang; Kathleen M Trybus; David J DeRosier; Susan Lowey; Dorit Hanein
Myosin isoforms show unique conformations in the actin-bound state.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3227-32.
2002: Arthur S Rovner; Patricia M Fagnant; Susan Lowey; Kathleen M Trybus
The carboxyl-terminal isoforms of smooth muscle myosin heavy chain determine thick filament assembly properties.
The Journal of cell biology 2002;156(1):113-23.
2001: Jeffrey R Moore; Elena B Krementsova; Kathleen M Trybus; David M Warshaw
Myosin V exhibits a high duty cycle and large unitary displacement.
The Journal of cell biology 2001;155(4):625-35.
2001: CE Berger; Patricia M Fagnant; S Heizmann; Kathleen M Trybus; Michael A Geeves
ADP binding induces an asymmetry between the heads of unphosphorylated myosin.
The Journal of biological chemistry 2001;276(26):23240-5.
2001: T Wendt; D Taylor; Kathleen M Trybus; K Taylor
Three-dimensional image reconstruction of dephosphorylated smooth muscle heavy meromyosin reveals asymmetry in the interaction between myosin heads and placement of subfragment 2.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4361-6.
2001: Anne-Marie Lauzon; Patricia M Fagnant; David M Warshaw; Kathleen M Trybus
Coiled-coil unwinding at the smooth muscle myosin head-rod junction is required for optimal mechanical performance.
Biophysical journal 2001;80(4):1900-4.
2001: Peteranne B Joel; Kathleen M Trybus; H L Sweeney
Two conserved lysines at the 50/20-kDa junction of myosin are necessary for triggering actin activation.
The Journal of biological chemistry 2001;276(5):2998-3003.
2000: Kathleen M Trybus
Biochemical studies of myosin.
Methods (San Diego, Calif.) 2000;22(4):327-35.
2000: Niels Volkmann; Dorit Hanein; G Ouyang; Kathleen M Trybus; David J DeRosier; Susan Lowey
Evidence for cleft closure in actomyosin upon ADP release.
Nature structural biology 2000;7(12):1147-55.
2000: David M Warshaw; WH Guilford; Y Freyzon; Elena B Krementsova; Kimberly A Palmiter; Matthew J Tyska; Josh E Baker; Kathleen M Trybus
The light chain binding domain of expressed smooth muscle heavy meromyosin acts as a mechanical lever.
The Journal of biological chemistry 2000;275(47):37167-72.
2000: H Yamashita; Matthew J Tyska; David M Warshaw; Susan Lowey; Kathleen M Trybus
Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy.
The Journal of biological chemistry 2000;275(36):28045-52.
1999: T Wendt; D Taylor; T Messier; Kathleen M Trybus; Kenneth A Taylor
Visualization of head-head interactions in the inhibited state of smooth muscle myosin.
The Journal of cell biology 1999;147(7):1385-90.
1999: Kathleen M Trybus; Elena B Krementsova; Y Freyzon
Kinetic characterization of a monomeric unconventional myosin V construct.
The Journal of biological chemistry 1999;274(39):27448-56.
1999: Matthew J Tyska; DE Dupuis; WH Guilford; Joseph B Patlak; Guillermina S Waller; Kathleen M Trybus; David M Warshaw; Susan Lowey
Two heads of myosin are better than one for generating force and motion.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4402-7.
1998: Anne-Marie Lauzon; Kathleen M Trybus; David M Warshaw
Molecular mechanics of two smooth muscle heavy meromyosin constructs that differ by an insert in the motor domain.
Acta physiologica Scandinavica 1998;164(4):357-61.
1998: Anne-Marie Lauzon; Matthew J Tyska; Arthur S Rovner; Y Freyzon; David M Warshaw; Kathleen M Trybus
A 7-amino-acid insert in the heavy chain nucleotide binding loop alters the kinetics of smooth muscle myosin in the laser trap.
Journal of muscle research and cell motility 1998;19(8):825-37.
1998: Roberto Dominguez; Y Freyzon; Kathleen M Trybus; Carolyn Cohen
Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state.
Cell 1998;94(5):559-71.
1998: Kathleen M Trybus; V Naroditskaya; H Lee Sweeney
The light chain-binding domain of the smooth muscle myosin heavy chain is not the only determinant of regulation.
The Journal of biological chemistry 1998;273(29):18423-8.
1998: David M Warshaw; E Hayes; D Gaffney; Anne-Marie Lauzon; J Wu; G Kennedy; Kathleen M Trybus; Susan Lowey; C Berger
Myosin conformational states determined by single fluorophore polarization.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8034-9.
1997: Arthur S Rovner; Y Freyzon; Kathleen M Trybus
An insert in the motor domain determines the functional properties of expressed smooth muscle myosin isoforms.
Journal of muscle research and cell motility 1997;18(1):103-10.
1997: Kathleen M Trybus; Y Freyzon; Lynn Z Faust; H Lee Sweeney
Spare the rod, spoil the regulation: necessity for a myosin rod.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):48-52.
1995: Arthur S Rovner; Y Freyzon; Kathleen M Trybus
Chimeric substitutions of the actin-binding loop activate dephosphorylated but not phosphorylated smooth muscle heavy meromyosin.
The Journal of biological chemistry 1995;270(51):30260-3.
1995: Susan Lowey; Kathleen M Trybus
Role of skeletal and smooth muscle myosin light chains.
Biophysical journal 1995;68(4 Suppl):120S-126S; discussion 126S-127S.
1994: Peter VanBuren; G S Waller; D E Harris; Kathleen M Trybus; David M Warshaw; Susan Lowey
The essential light chain is required for full force production by skeletal muscle myosin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12403-7.
1994: Kathleen M Trybus
Role of myosin light chains.
Journal of muscle research and cell motility 1994;15(6):587-94.
1994: Arie Horowitz; Kathleen M Trybus; D S Bowman; Fred S Fay
Antibodies probe for folded monomeric myosin in relaxed and contracted smooth muscle.
The Journal of cell biology 1994;126(5):1195-200.
1994: Kathleen M Trybus
Regulation of expressed truncated smooth muscle myosins. Role of the essential light chain and tail length.
The Journal of biological chemistry 1994;269(33):20819-22.
1994: Kathleen M Trybus; G S Waller; T A Chatman
Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain.
The Journal of cell biology 1994;124(6):963-9.
1994: H Lee Sweeney; Zhaohai Yang; G Zhi; James T Stull; Kathleen M Trybus
Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1490-4.
1993: Susan Lowey; G S Waller; Kathleen M Trybus
Skeletal muscle myosin light chains are essential for physiological speeds of shortening.
Nature 1993;365(6445):454-6.
1993: Susan Lowey; G S Waller; Kathleen M Trybus
Function of skeletal muscle myosin heavy and light chain isoforms by an in vitro motility assay.
The Journal of biological chemistry 1993;268(27):20414-8.
1993: Kathleen M Trybus; T A Chatman
Chimeric regulatory light chains as probes of smooth muscle myosin function.
The Journal of biological chemistry 1993;268(6):4412-9.
1992: Arie Horowitz; Kathleen M Trybus
Inhibition of smooth muscle myosin's activity and assembly by an anti-rod monoclonal antibody.
The Journal of biological chemistry 1992;267(36):26091-6.
1992: Joe R Haeberle; Kathleen M Trybus; M E Hemric; David M Warshaw
The effects of smooth muscle caldesmon on actin filament motility.
The Journal of biological chemistry 1992;267(32):23001-6.
1991: David M Warshaw; J M Desrosiers; S S Work; Kathleen M Trybus
Effects of MgATP, MgADP, and Pi on actin movement by smooth muscle myosin.
The Journal of biological chemistry 1991;266(36):24339-43.
1991: Kathleen M Trybus
Assembly of cytoplasmic and smooth muscle myosins.
Current opinion in cell biology 1991;3(1):105-11.
1991: Kathleen M Trybus; D M Warshaw
Regulation of the interaction between smooth muscle myosin and actin.
Journal of cell science. Supplement 1991;14():87-9.
1991: Kathleen M Trybus
Regulation of smooth muscle myosin.
Cell motility and the cytoskeleton 1991;18(2):81-5.
1991: David M Warshaw; Kathleen M Trybus
In vitro evidence for smooth muscle crossbridge mechanical interactions.
Advances in experimental medicine and biology 1991;304():53-9.
1990: David M Warshaw; J M Desrosiers; S S Work; Kathleen M Trybus
Smooth muscle myosin cross-bridge interactions modulate actin filament sliding velocity in vitro.
The Journal of cell biology 1990;111(2):453-63.
1990: David M Warshaw; J M Desrosiers; S S Work; Kathleen M Trybus
Mechanical interaction of smooth muscle crossbridges modulates actin filament velocity in vitro.
Progress in clinical and biological research 1990;327():815-26.
1989: Kathleen M Trybus
Filamentous smooth muscle myosin is regulated by phosphorylation.
The Journal of cell biology 1989;109(6 Pt 1):2887-94.
1989: Kathleen M Trybus; L Henry
Monoclonal antibodies detect and stabilize conformational states of smooth muscle myosin.
The Journal of cell biology 1989;109(6 Pt 1):2879-86.
1988: Kathleen M Trybus; Susan Lowey
The regulatory light chain is required for folding of smooth muscle myosin.
The Journal of biological chemistry 1988;263(31):16485-92.
1987: Kathleen M Trybus; Susan Lowey
Subunit exchange between smooth muscle myosin filaments.
The Journal of cell biology 1987;105(6 Pt 2):3021-30.
1987: Kathleen M Trybus; Susan Lowey
Assembly of smooth muscle myosin minifilaments: effects of phosphorylation and nucleotide binding.
The Journal of cell biology 1987;105(6 Pt 2):3007-19.
1987: Kathleen M Trybus; Susan Lowey
Subunit exchange between smooth muscle myosin filaments.
Progress in clinical and biological research 1987;245():81-90.
1985: Kathleen M Trybus; Susan Lowey
Mechanism of smooth muscle myosin phosphorylation.
The Journal of biological chemistry 1985;260(29):15988-95.
1984: Kathleen M Trybus; Susan Lowey
Conformational states of smooth muscle myosin. Effects of light chain phosphorylation and ionic strength.
The Journal of biological chemistry 1984;259(13):8564-71.
1982: Kathleen M Trybus; T W Huiatt; Susan Lowey
A bent monomeric conformation of myosin from smooth muscle.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(20):6151-5.