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Karl Tryggvason

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Juha Risto Matias Ojala; Timo Pikkarainen; Göran Elmberger; Karl Tryggvason
Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor a5-deficient mice.
Patricia Q Rodriguez; Karl Tryggvason; Annika Wernerson; Michaela Auer-Grumbach; Gianni Celsi; Nobuyuki Hamajima; Bernhard Lohkamp; Christoph Johannes Mache; Jaakko Patrakka
Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy.
Bing He; Juha R M Ojala; Ann-Charlotte Andersson; AM Osterholm; Karl Tryggvason
A remote cis-acting variant at 3q links glomerular NCK1 to diabetic nephropathy.

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2013: Juha Risto Matias Ojala; Timo Pikkarainen; Göran Elmberger; Karl Tryggvason
Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor a5-deficient mice.
The American journal of pathology 2013;182(5):1681-95.
2013: Patricia Q Rodriguez; Karl Tryggvason; Annika Wernerson; Michaela Auer-Grumbach; Gianni Celsi; Nobuyuki Hamajima; Bernhard Lohkamp; Christoph Johannes Mache; Jaakko Patrakka
Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy.
Pediatric nephrology (Berlin, Germany) 2013;28(2):339-43.
2013: Bing He; Juha R M Ojala; Ann-Charlotte Andersson; AM Osterholm; Karl Tryggvason
A remote cis-acting variant at 3q links glomerular NCK1 to diabetic nephropathy.
PloS one 2013;8(2):e56414.
2013: Laleh Sistani; Karl Tryggvason; Mathias Uhlen; Annika Wernerson; Christer Betsholtz; Kjell Hultenby; Hannu Jalanko; Patricia Q Rodriguez; Jaakko Patrakka
Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.
Kidney international 2013;83(1):63-71.
2012: Baohua Liu; Xinguang Liu; Yousin Suh; Karl Tryggvason; Zimei Wang; Xi Yang; Bojian Zheng; Huiling Zheng; Shrestha Ghosh; Guoxiang Jin; Matt Kaeberlein; Brian K Kennedy; Zhongjun Zhou
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.
Cell metabolism 2012;16(6):738-50.
2012: Ljubica Perisic; Christer Betsholtz; Hjalmar Brismar; Fredrik Dunér; Jenny Hulkko; Kjell Hultenby; Mark Lal; Jaakko Patrakka; Ying Sun; Karl Tryggvason; Mathias Uhlen; Annika Wernerson; Björn Önfelt; Timo Pikkarainen
Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics.
Kidney international 2012;82(10):1071-83.
2012: Juha Risto Matias Ojala; Timo Pikkarainen; Anna Domogatskaya; Karl Tryggvason; Sergey Rodin
A novel scavenger receptor 5-based antibiotic-independent selection method for generation of stable recombinant protein-producing mammalian cell lines especially suitable for proteins affecting cell adhesion.
BioTechniques 2012;53(4):221-30.
2012: Mark A Lal; Karl Tryggvason
Knocking out podocyte rho GTPases: and the winner is...
Journal of the American Society of Nephrology : JASN 2012;23(7):1128-9.
2012: Kui Ming Chan; Guoxiang Jin; Kaisa Lehti; Baohua Liu; Karl Tryggvason; Hoi Leong Xavier Wong; Renhai Cao; Yihai Cao; Zhongjun Zhou
MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.
Developmental cell 2012;22(6):1176-90.
2012: Merlin C Thomas; Per-Henrik Groop; Karl Tryggvason
Towards understanding the inherited susceptibility for nephropathy in diabetes.
Current opinion in nephrology and hypertension 2012;21(2):195-202.
2012: Anna Domogatskaya; Sergey Rodin; Karl Tryggvason
Functional diversity of laminins.
Annual review of cell and developmental biology 2012;28():523-53.
2011: Zhijie Xiao; Timo Pikkarainen; Seppo Vainio; Christer Betsholtz; Lijun Chi; Dadi Niu; Masatoshi Nukui; Jaakko Patrakka; Timo Pikkarainan; Karl Tryggvason
Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.
Developmental dynamics : an official publication of the American Association of Anatomists 2011;240(12):2646-56.
2011: Denise Stenzel; Karl Tryggvason; Hannah Armer; Lucy Collinson; Anna Domogatskaya; Soline Estrach; Claudio A Franco; Amel Mettouchi; Sergey Rodin; Ian Rosewell; Dominique Sauvaget; Andreas Schertel; Lydia Sorokin; Holger Gerhardt
Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo.
EMBO reports 2011;12(11):1135-43.
2011: Yukino Nishibori; Jenny Norlin; Masatoshi Nukui; Asmundur Oddsson; Mataleena Parikka; Jaakko Patrakka; Elisabeth Raschperger; Christer Betsholtz; Lwaki Ebarasi; Bing He; Kjell Hultenby; Kan Katayama; Mathias Uhlén; Annika Wernerson; Karl Tryggvason
Glcci1 deficiency leads to proteinuria.
Journal of the American Society of Nephrology : JASN 2011;22(11):2037-46.
2011: Laleh Sistani; Karl Tryggvason; Sunil Udumala; Mathias Uhlen; Annika Wernerson; Christer Betsholtz; Fredrik Dunér; Kjell Hultenby; Jaakko Patrakka
Pdlim2 is a novel actin-regulating protein of podocyte foot processes.
Kidney international 2011;80(10):1045-54.
2011: Suma Yaddanapudi; Phillip Ruiz; Mario Schiffer; Sanja Sever; Andrey S Shaw; Karl Tryggvason; Changli Wei; Zhijie Xiao; Mehmet Mete Altintas; Markus Bitzer; Faul Christian; Isabel Fernandez; Jan B Flesche; Anna-Lena Forst; Florian Grahammer; Changkyu Gu; Tobias B Huber; Wenjun Ju; Andreas D Kistler; Jing Li; Tobias Lohmüller; Clemens C Möller; Jaakko Patrakka; Vasil Peev; Maria Pia Rastaldi; Thomas Reinheckel; Jochen Reiser
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.
The Journal of clinical investigation 2011;121(10):3965-80.
2011: Lwaki Ebarasi; Kjell Hultenby; Asmundur Oddsson; Christer Betsholtz; Karl Tryggvason
Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology.
Current opinion in nephrology and hypertension 2011;20(4):416-24.
2011: Bing He; Lwaki Ebarasi; Kjell Hultenby; Karl Tryggvason; Christer Betsholtz
Podocin-green fluorescence protein allows visualization and functional analysis of podocytes.
Journal of the American Society of Nephrology : JASN 2011;22(6):1019-23.
2011: Nicole Wagner; Harris Morrison; Sophie Pagnotta; Jean-Francois Michiels; Yannick Schwab; Karl Tryggvason; Andreas Schedl; Kay-Dietrich Wagner
The podocyte protein nephrin is required for cardiac vessel formation.
Human molecular genetics 2011;20(11):2182-94.
2011: Yuko Oikawa; Johan Hansson; Takako Sasaki; Patricia Rousselle; Anna Domogatskaya; Sergey Rodin; Karl Tryggvason; Manuel Patarroyo
Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors.
Experimental cell research 2011;317(8):1119-33.
2011: Subhankar Mukhopadhyay; Audrey Varin; Yunying Chen; Baoying Liu; Karl Tryggvason; Siamon Gordon
SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens.
Blood 2011;117(4):1319-28.
2011: Zhijie Xiao; Daniel R Storm; Minoru Takemoto; Karl Tryggvason; Christer Betsholtz; Guy C Chan; Liqun He; Hannu Jalanko; Jaakko Patrakka
Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria.
Nephron. Experimental nephrology 2011;118(3):e39-48.
2011: Xiangjun Xu; Jaakko Patrakka; Laleh Sistani; Mathias Uhlen; Hannu Jalanko; Christer Betsholtz; Karl Tryggvason
Expression of novel podocyte-associated proteins sult1b1 and ankrd25.
Nephron. Experimental nephrology 2011;117(2):e39-46.
2010: Jaana Hyvärinen; Mataleena Parikka; Raija Sormunen; Mika Rämet; Karl Tryggvason; Kari I Kivirikko; Johanna Myllyharju; Peppi Koivunen
Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function.
The Journal of biological chemistry 2010;285(53):42023-32.
2010: Sergey Rodin; Anna Domogatskaya; Susanne Ström; Emil M Hansson; Kenneth R Chien; José Inzunza; Outi Hovatta; Karl Tryggvason
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511.
Nature biotechnology 2010;28(6):611-5.
2010: Jaakko Patrakka; Karl Tryggvason
Molecular make-up of the glomerular filtration barrier.
Biochemical and biophysical research communications 2010;396(1):164-9.
2010: Yunying Chen; Fredrik Wermeling; Johanna Sundqvist; Ann-Beth Jonsson; Karl Tryggvason; Timo Pikkarainen; Mikael C I Karlsson
A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses.
European journal of immunology 2010;40(5):1451-60.
2010: Fredrik Dunér; Karin Lindström; Kjell Hultenby; Jenny Hulkko; Jaakko Patrakka; Karl Tryggvason; Borje Haraldsson; Annika Wernerson; Erna Pettersson
Permeability, ultrastructural changes, and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis.
Nephron. Experimental nephrology 2010;116(2):e42-52.
2010: Alessia Fornoni; Jongmin Jeon; Javier Varona Santos; Lorenzo Cobianchi; Alexandra Jauregui; Luca Inverardi; Slavena A Mandic; Christina Bark; Kevin Johnson; George McNamara; Antonello Pileggi; R. Damaris Molano; Jochen Reiser; Karl Tryggvason; Dontscho Kerjaschki; Per-Olof Berggren; Peter Mundel; Camillo Ricordi
Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release.
Diabetes 2010;59(1):190-9.
2010: Olga Beltcheva; Eyrun Edda Hjorleifsdottir; Sirpa Kontusaari; Karl Tryggvason
Sp1 specifically binds to an evolutionarily conserved DNA segment within a region necessary for podocyte-specific expression of nephrin.
Nephron. Experimental nephrology 2010;114(1):e15-22.
2009: Sirpa Salo; Ariel Boutaud; Anker Jon Hansen; Liqun He; Yi Sun; Sylvia Morales; Amy Venturini; Paula Martin; Pasi A Nokelainen; Christer Betsholtz; Ida Stenfeldt Mathiasen; Karl Tryggvason
Antibodies blocking adhesion and matrix binding domains of laminin-332 inhibit tumor growth and metastasis in vivo.
International journal of cancer. Journal international du cancer 2009;125(8):1814-25.
2009: Wondossen Sime; Carolina Lunderius-Andersson; Mattias Enoksson; Patricia Rousselle; Karl Tryggvason; Gunnar Nilsson; Ilkka Harvima; Manuel Patarroyo
Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha3beta1 integrin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4657-65.
2009: Lwaki Ebarasi; Liqun He; Kjell Hultenby; Minoru Takemoto; Christer Betsholtz; Karl Tryggvason; Arindam Majumdar
A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier.
Developmental biology 2009;334(1):1-9.
2009: Jaakko Patrakka; Karl Tryggvason
New insights into the role of podocytes in proteinuria.
Nature reviews. Nephrology 2009;5(8):463-8.
2009: Yuji Sekine; Yukino Nishibori; Yoshihiro Akimoto; Akihiko Kudo; Noriko Ito; Daisuke Fukuhara; Ryota Kurayama; Eiji Higashihara; Ellappan Babu; Yoshikatsu Kanai; Katsuhiko Asanuma; Michio Nagata; Arindam Majumdar; Karl Tryggvason; Kunimasa Yan
Amino acid transporter LAT3 is required for podocyte development and function.
Journal of the American Society of Nephrology : JASN 2009;20(7):1586-96.
2009: Seth Goldberg; Scott Harvey; Jeanette Cunningham; Karl Tryggvason; Jeffrey H Miner
Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(7):2044-51.
2009: Dawn Bowdish; Kaori Sakamoto; Mi-Jeong Kim; Mariliis Kroos; Subhankar Mukhopadhyay; Cynthia A Leifer; Karl Tryggvason; Siamon Gordon; David G Russell
MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.
PLoS pathogens 2009;5(6):e1000474.
2009: Chuan Wu; Fredrik Ivars; Per Anderson; Rupert Hallmann; Dietmar Vestweber; Per Nilsson; Horst Robenek; Karl Tryggvason; Jian Song; Eva Korpos; Karin Loser; Stefan Beissert; Elisabeth Georges-Labouesse; Lydia Sorokin
Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.
Nature medicine 2009;15(5):519-27.
2009: Oliver Gross; Dorin-Bogdan Borza; Hans-Joachim Anders; Christoph Licht; Manfred Weber; Stephan Segerer; Roser Torra; Marie-Claire Gubler; Laurence Heidet; Scott Harvey; Dominic Cosgrove; George Lees; Clifford Kashtan; Martin Gregory; Judy Savige; Jie Ding; Paul Thorner; Dale R Abrahamson; Corinne Antignac; Karl Tryggvason; Billy Hudson; Jeffrey H Miner
Stem cell therapy for Alport syndrome: the hope beyond the hype.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(3):731-4.
2009: Mariko Shimizu; Jamshid Khoshnoodi; Yoshihiro Akimoto; Hayato Kawakami; Hiroshi Hirano; Eiji Higashihara; Makoto Hosoyamada; Yuji Sekine; Ryota Kurayama; Hideaki Kurayama; Kensuke Joh; Jun Hirabayashi; Kenichi Kasai; Karl Tryggvason; Noriko Ito; Kunimasa Yan
Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome.
Laboratory investigation; a journal of technical methods and pathology 2009;89(2):178-95.
2009: Annette Plüddemann; Subhankar Mukhopadhyay; Marko Sankala; Silvana Savino; Mariagrazia Pizza; Rino Rappuoli; Karl Tryggvason; Siamon Gordon
SR-A, MARCO and TLRs differentially recognise selected surface proteins from Neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors.
Journal of innate immunity 2009;1(2):153-63.
2009: Ying Sun; Liqun He; Minoru Takemoto; Jaakko Patrakka; Timo Pikkarainen; Guillem Genové; Jenny Norlin; Katarina Truvé; Karl Tryggvason; Christer Betsholtz
Glomerular transcriptome changes associated with lipopolysaccharide-induced proteinuria.
American journal of nephrology 2009;29(6):558-70.
2009: Bing He; AM Osterholm; Anna Hoverfält; Carol Forsblom; Eyrún Edda Hjörleifsdóttir; Ann-Sofie Nilsson; Maikki Parkkonen; Janne Pitkäniemi; Astrádur Hreidarsson; Cinzia Sarti; Amy Jayne McKnight; A Peter Maxwell; Jaakko Tuomilehto; Per-Henrik Groop; Karl Tryggvason
Association of genetic variants at 3q22 with nephropathy in patients with type 1 diabetes mellitus.
American journal of human genetics 2009;84(1):5-13.
2008: Anna Domogatskaya; Sergey Rodin; Ariel Boutaud; Karl Tryggvason
Laminin-511 but not -332, -111, or -411 enables mouse embryonic stem cell self-renewal in vitro.
Stem cells (Dayton, Ohio) 2008;26(11):2800-9.
2008: Stefan Plantman; Manuel Patarroyo; Kaj Fried; Anna Domogatskaya; Karl Tryggvason; Henrik Hammarberg; Staffan Cullheim
Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.
Molecular and cellular neurosciences 2008;39(1):50-62.
2008: Gezahegn Gorfu; Ismo Virtanen; Mika Hukkanen; Veli-Pekka Lehto; Patricia Rousselle; Ellinor Kenne; Lennart Lindbom; Randall Kramer; Karl Tryggvason; Manuel Patarroyo
Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes.
Journal of leukocyte biology 2008;84(3):701-12.
2008: Fredrik Dunér; Jaakko Patrakka; Zhijie Xiao; Jenny Larsson; Alexios Vlamis-Gardikas; Erna Pettersson; Karl Tryggvason; Kjell Hultenby; Annika Wernerson
Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(8):2504-11.
2008: Karin Tran-Lundmark; Phan-Kiet Tran; Gabrielle Paulsson-Berne; Vincent Fridén; Raija Soininen; Karl Tryggvason; Thomas N Wight; Michael G Kinsella; Jan Borén; Ulf Hedin
Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation.
Circulation research 2008;103(1):43-52.
2008: Mira Tulla; Matti Lahti; J Santeri Puranen; Anna-Maria Brandt; Jarmo Käpylä; Anna Domogatskaya; Tiina A Salminen; Karl Tryggvason; Mark S Johnson; Jyrki Heino
Effects of conformational activation of integrin alpha 1I and alpha 2I domains on selective recognition of laminin and collagen subtypes.
Experimental cell research 2008;314(8):1734-43.
2008: Lars Jakobsson; Anna Domogatskaya; Karl Tryggvason; David Edgar; Lena Claesson-Welsh
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1530-9.
2008: Jesús Espada; Ignacio Varela; Ignacio Flores; Alejandro P Ugalde; Juan Cadiñanos; Alberto Pendas; Colin L Stewart; Karl Tryggvason; María A Blasco; José M P Freije; Carlos López-Otín
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice.
The Journal of cell biology 2008;181(1):27-35.
2008: Stefania Cotta Doné; Minoru Takemoto; Liqun He; Ying Sun; K Hultenby; Christer Betsholtz; Karl Tryggvason
Nephrin is involved in podocyte maturation but not survival during glomerular development.
Kidney international 2008;73(6):697-704.
2008: Liqun He; Ying Sun; Minoru Takemoto; Jenny Norlin; Karl Tryggvason; Tore Samuelsson; Christer Betsholtz
The glomerular transcriptome and a predicted protein-protein interaction network.
Journal of the American Society of Nephrology : JASN 2008;19(2):260-8.
2007: Tomoyuki Kawataki; Tetsu Yamane; Hirofumi Naganuma; Patricia Rousselle; Ingegerd Andurén; Karl Tryggvason; Manuel Patarroyo
Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of alpha5-laminin(s) and alpha3beta1 integrin.
Experimental cell research 2007;313(18):3819-31.
2007: Laura Genís; Pilar Gonzalo; Antonio S Tutor; Beatriz G Gálvez; Antonio Martínez-Ruiz; Carlos Zaragoza; Santiago Lamas; Karl Tryggvason; Suneel S Apte; Alicia G Arroyo
Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells.
Blood 2007;110(8):2916-23.
2007: Fredrik Wermeling; Yunying Chen; Timo Pikkarainen; Annika Scheynius; Ola Winqvist; Shozo Izui; Jeffrey V Ravetch; Karl Tryggvason; Mikael C I Karlsson
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus.
The Journal of experimental medicine 2007;204(10):2259-65.
2007: Hong Qian; Elisabeth Georges-Labouesse; Alexander Nyström; Anna Domogatskaya; Karl Tryggvason; Sten Eirik W Jacobsen; Marja Ekblom
Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells.
Blood 2007;110(7):2399-407.
2007: Jaakko Patrakka; Karl Tryggvason
Nephrin--a unique structural and signaling protein of the kidney filter.
Trends in molecular medicine 2007;13(9):396-403.
2007: Aya Nakajo; Jamshid Khoshnoodi; Hitoshi Takenaka; Emi Hagiwara; Takashi Watanabe; Hayato Kawakami; Ryota Kurayama; Yuji Sekine; Fumio Bessho; Shori Takahashi; Agnieszka Swiatecka-Urban; Karl Tryggvason; Kunimasa Yan
Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance.
Journal of the American Society of Nephrology : JASN 2007;18(9):2554-64.
2007: Noora Vainionpää; Veli-Pekka Lehto; Karl Tryggvason; Ismo Virtanen
Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function.
Laboratory investigation; a journal of technical methods and pathology 2007;87(8):780-91.
2007: Juha R M Ojala; Timo Pikkarainen; Ari Tuuttila; Tatyana Sandalova; Karl Tryggvason
Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition.
The Journal of biological chemistry 2007;282(22):16654-66.
2007: M Simo Arredouani; Francesca Franco; Amy Imrich; Alexey Fedulov; Xin Lu; David Perkins; Raija Soininen; Karl Tryggvason; Steven D Shapiro; Lester Kobzik
Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5912-20.
2007: Liqun He; Ying Sun; Jaakko Patrakka; P Mostad; Jenny Norlin; Zhijie Xiao; J Andrae; Karl Tryggvason; T Samuelsson; Christer Betsholtz; Minoru Takemoto
Glomerulus-specific mRNA transcripts and proteins identified through kidney expressed sequence tag database analysis.
Kidney international 2007;71(9):889-900.
2007: Morten Dahl; Alison K Bauer; M Simo Arredouani; Raija Soininen; Karl Tryggvason; Steven R Kleeberger; Lester Kobzik
Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II.
The Journal of clinical investigation 2007;117(3):757-64.
2007: Jaakko Patrakka; Zhijie Xiao; Masatoshi Nukui; Minoru Takemoto; Liqun He; Asmundur Oddsson; Ljubica Perisic; Anne Kaukinen; Cristina Al-Khalili Szigyarto; Mathias Uhlén; Hannu Jalanko; Christer Betsholtz; Karl Tryggvason
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.
Journal of the American Society of Nephrology : JASN 2007;18(3):689-97.
2007: Jamshid Khoshnoodi; Salisha Hill; Karl Tryggvason; Billy Hudson; David B Friedman
Identification of N-linked glycosylation sites in human nephrin using mass spectrometry.
Journal of mass spectrometry : JMS 2007;42(3):370-9.
2007: Qing Qiao; Anne-May Osterholm; Bing He; Janne Pitkäniemi; Heather J Cordell; Cinzia Sarti; Leena Kinnunen; Eva Tuomilehto-Wolf; Karl Tryggvason; Jaakko Tuomilehto
A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland.
BMC genetics 2007;8():84.
2007: Christer Betsholtz; Liqun He; Minoru Takemoto; Jenny Norlin; Ying Sun; Jaakko Patrakka; Karl Tryggvason
The glomerular transcriptome and proteome.
Nephron. Experimental nephrology 2007;106(2):e32-6.
2007: A-M Osterholm; B He; Janne Pitkaniemi; L Albinsson; T Berg; C Sarti; J Tuomilehto; Karl Tryggvason
Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome 3q.
Kidney international 2007;71(2):140-5.
2006: Yunying Chen; Marko Sankala; Juha R M Ojala; Yi Sun; Ari Tuuttila; David E Isenman; Karl Tryggvason; Timo Pikkarainen
A phage display screen and binding studies with acetylated low density lipoprotein provide evidence for the importance of the scavenger receptor cysteine-rich (SRCR) domain in the ligand-binding function of MARCO.
The Journal of biological chemistry 2006;281(18):12767-75.
2006: Tarak Srivastava; Robert E Garola; Marjo Kestila; Karl Tryggvason; Vesa Ruotsalainen; Mukut Sharma; Virginia J Savin; Hannu Jalanko; Bradley A Warady
Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish type.
Pediatric nephrology (Berlin, Germany) 2006;21(5):711-8.
2006: Hong Qian; Karl Tryggvason; Sten Eirik W Jacobsen; Marja Ekblom
Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins.
Blood 2006;107(9):3503-10.
2006: Karl Tryggvason; Timo Pikkarainen; Jaakko Patrakka
Nck links nephrin to actin in kidney podocytes.
Cell 2006;125(2):221-4.
2006: Y Fujii; Jamshid Khoshnoodi; Hitoshi Takenaka; Makoto Hosoyamada; A Nakajo; Fumio Bessho; Akihiko Kudo; Shori Takahashi; Y Arimura; A Yamada; T Nagasawa; Vesa Ruotsalainen; Karl Tryggvason; A S Lee; Kunimasa Yan
The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases.
Kidney international 2006;69(8):1350-9.
2006: Subhankar Mukhopadhyay; Yunying Chen; Marko Sankala; Leanne Peiser; Timo Pikkarainen; Georg Kraal; Karl Tryggvason; Siamon Gordon
MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis.
European journal of immunology 2006;36(4):940-9.
2006: Karl Tryggvason; Jaakko Patrakka; Jorma Wartiovaara
Hereditary proteinuria syndromes and mechanisms of proteinuria.
The New England journal of medicine 2006;354(13):1387-401.
2006: Minoru Takemoto; Liqun He; Jenny Norlin; Jaakko Patrakka; Zhijie Xiao; Tatiana Petrova; Cecilia Bondjers; Julia Asp; Elisabet Wallgard; Ying Sun; Tore Samuelsson; Petter Mostad; Samuel Lundin; Naoyuki Miura; Yoshikazu Sado; Kari Alitalo; Susan E Quaggin; Karl Tryggvason; Christer Betsholtz
Large-scale identification of genes implicated in kidney glomerulus development and function.
The EMBO journal 2006;25(5):1160-74.
2006: Ganka Nikolova; Normund Jabs; Irena Konstantinova; Anna Domogatskaya; Karl Tryggvason; Lydia Sorokin; Reinhard Fässler; Guoqiang Gu; Hans-Peter Gerber; Napoleone Ferrara; Douglas A Melton; Eckhard Lammert
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
Developmental cell 2006;10(3):397-405.
2006: Karl Tryggvason; Jaakko Patrakka
Thin basement membrane nephropathy.
Journal of the American Society of Nephrology : JASN 2006;17(3):813-22.
2006: J-H Martens; Julia Kzhyshkowska; M Falkowski-Hansen; Kai Schledzewski; Alexei Gratchev; U Mansmann; C Schmuttermaier; Edgar Dippel; Wolfgang Koenen; F Riedel; Marko Sankala; Karl Tryggvason; Lester Kobzik; Gerhard Moldenhauer; Bernd Arnold; Sergij Goerdt
Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis.
The Journal of pathology 2006;208(4):574-89.
2006: Zenebech Wondimu; Gezahegn Gorfu; Tomoyuki Kawataki; Sergei Smirnov; Peter D Yurchenco; Karl Tryggvason; Manuel Patarroyo
Characterization of commercial laminin preparations from human placenta in comparison to recombinant laminins 2 (alpha2beta1gamma1), 8 (alpha4beta1gamma1), 10 (alpha5beta1gamma1).
Matrix biology : journal of the International Society for Matrix Biology 2006;25(2):89-93.
2006: Jianming Wang; Masahiko Hoshijima; Jason Lam; Zhongjun Zhou; Anna Jokiel; Nancy Dalton; Kjell Hultenby; Pilar Ruiz-Lozano; John Ross; Karl Tryggvason; Kenneth R Chien
Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice.
The Journal of biological chemistry 2006;281(1):213-20.
2006: Ayele Nigatu; Wondossen Sime; Gezahegn Gorfu; Tarekegn Geberhiwot; Ingegerd Andurén; Sulev Ingerpuu; Masayuki Doi; Karl Tryggvason; Paul Hjemdahl; Manuel Patarroyo
Megakaryocytic cells synthesize and platelets secrete alpha5-laminins, and the endothelial laminin isoform laminin 10 (alpha5beta1gamma1) strongly promotes adhesion but not activation of platelets.
Thrombosis and haemostasis 2006;95(1):85-93.
2005: Yunying Chen; Timo Pikkarainen; Outi Elomaa; Raija Soininen; Tatsuhiko Kodama; Georg Kraal; Karl Tryggvason
Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8173-80.
2005: M Simo Arredouani; Aiyappa Palecanda; Henry Koziel; Yuh-Ching Huang; Amy Imrich; Timothy H Sulahian; Yao Yu Ning; Zhiping Yang; Timo Pikkarainen; Marko Sankala; Sara O Vargas; Motohiro Takeya; Karl Tryggvason; Lester Kobzik
MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6058-64.
2005: Ignacio Varela; Juan Cadiñanos; Alberto Pendas; Ana Gutiérrez-Fernández; Alicia R Folgueras; Luis M Sánchez; Zhongjun Zhou; Francisco J Rodríguez; Colin L Stewart; José A Vega; Karl Tryggvason; José M P Freije; Carlos López-Otín
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.
Nature 2005;437(7058):564-8.
2005: Baohua Liu; Jianming Wang; Kui Ming Chan; Wai Mui Tjia; Wen Deng; Xinyuan Guan; Jian-Dong Huang; Kai Man Li; Pui Yin Chau; David J Chen; Duanqing Pei; Alberto Pendas; Juan Cadiñanos; Carlos López-Otín; Hung-Fat Tse; Chris Hutchison; Junjie Chen; Yihai Cao; Kathryn S E Cheah; Karl Tryggvason; Zhongjun Zhou
Genomic instability in laminopathy-based premature aging.
Nature medicine 2005;11(7):780-5.
2005: Hiroyuki Morita; Ashio Yoshimura; Kiyoko Inui; Terukuni Ideura; Hideto Watanabe; Ling Wang; Raija Soininen; Karl Tryggvason
Heparan sulfate of perlecan is involved in glomerular filtration.
Journal of the American Society of Nephrology : JASN 2005;16(6):1703-10.
2005: Wilhelm Wallquist; Stefan Plantman; Sebastian Thams; Jill Thyboll; Jarkko Kortesmaa; Jan Lännergren; Anna Domogatskaya; Sven Ove Ogren; Mårten Risling; Henrik Hammarberg; Karl Tryggvason; Staffan Cullheim
Impeded interaction between Schwann cells and axons in the absence of laminin alpha4.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(14):3692-700.
2005: Karl Tryggvason; Jorma Wartiovaara
How does the kidney filter plasma?
Physiology (Bethesda, Md.) 2005;20():96-101.
2005: Beatriz G Gálvez; Laura Genís; Salomón Matías-Román; Samantha A Oblander; Karl Tryggvason; Suneel S Apte; Alicia G Arroyo
Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis.
The Journal of biological chemistry 2005;280(2):1292-8.
2005: Patricia Stoltzfus; Kerstin Heselmeyer-Haddad; J Castro; N White; Claes Silfverswärd; Kerstin Sjövall; Nina Einhorn; Karl Tryggvason; Gert Auer; Thomas Ried; Britta Nordström
Gain of chromosome 3q is an early and consistent genetic aberration in carcinomas of the vulva.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2005;15(1):120-6.
2005: Xiao Li Liu; Pekka Kilpeläinen; Ulf Hellman; Yi Sun; Jorma Wartiovaara; Ekaterina Morgunova; Timo Pikkarainen; Kunimasa Yan; Anders P Jonsson; Karl Tryggvason
Characterization of the interactions of the nephrin intracellular domain.
The FEBS journal 2005;272(1):228-43.
2005: Samantha A Oblander; Zhongjun Zhou; Beatriz G Gálvez; Barry Starcher; John M Shannon; Madeleine Durbeej; Alicia G Arroyo; Karl Tryggvason; Suneel S Apte
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation.
Developmental biology 2005;277(1):255-69.
2004: Jorma Wartiovaara; Lars-Göran Ofverstedt; Jamshid Khoshnoodi; Jingjing Zhang; Eetu Mäkelä; Sara Sandin; Vesa Ruotsalainen; R Holland Cheng; Hannu Jalanko; Ulf Skoglund; Karl Tryggvason
Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.
The Journal of clinical investigation 2004;114(10):1475-83.
2004: Yukino Nishibori; Li Liu; Makoto Hosoyamada; Hitoshi Endou; Akihiko Kudo; Hitoshi Takenaka; Eiji Higashihara; Fumio Bessho; Shori Takahashi; David B Kershaw; Vesa Ruotsalainen; Karl Tryggvason; Jamshid Khoshnoodi; Kunimasa Yan
Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane.
Kidney international 2004;66(5):1755-65.
2004: Zenebech Wondimu; Tarekegn Geberhiwot; Sulev Ingerpuu; Erkki Juronen; Xun Xie; Lennart Lindbom; Masayuki Doi; Jarkko Kortesmaa; Jill Thyboll; Karl Tryggvason; Bengt Fadeel; Manuel Patarroyo
An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis.
Blood 2004;104(6):1859-66.
2004: Ursula Mirastschijski; Zhongjun Zhou; Ola Rollman; Karl Tryggvason; Magnus Ågren
Wound healing in membrane-type-1 matrix metalloproteinase-deficient mice.
The Journal of investigative dermatology 2004;123(3):600-2.
2004: M Simo Arredouani; Zhiping Yang; YaoYu Ning; Guozhong Qin; Raija Soininen; Karl Tryggvason; Lester Kobzik
The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles.
The Journal of experimental medicine 2004;200(2):267-72.
2004: Zhongjun Zhou; Jianming Wang; Renhai Cao; Hiroyuki Morita; Raija Soininen; Kui Ming Chan; Baohua Liu; Yihai Cao; Karl Tryggvason
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice.
Cancer research 2004;64(14):4699-702.
2004: Patricia Stoltzfus; Sirpa Salo; Elina Eriksson; Ulla Aspenblad; Karl Tryggvason; Gert Auer; Elisabeth Avall-Lundqvist
Laminin-5 gamma2 chain expression facilitates detection of invasive squamous cell carcinoma of the uterine cervix.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2004;23(3):215-22.
2004: Xiao Li Liu; Stefania Cotta Doné; Kunimasa Yan; Pekka Kilpeläinen; Timo Pikkarainen; Karl Tryggvason
Defective trafficking of nephrin missense mutants rescued by a chemical chaperone.
Journal of the American Society of Nephrology : JASN 2004;15(7):1731-8.
2004: Zhongjun Zhou; Masayuki Doi; Jianming Wang; Renhai Cao; Baohua Liu; Kui Ming Chan; Jarkko Kortesmaa; Lydia Sorokin; Yihai Cao; Karl Tryggvason
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice.
Cancer research 2004;64(12):4059-63.
2004: Arvi-Matti Kuusniemi; Marjo Kestilä; Jaakko Patrakka; Anne-Tiina Lahdenkari; Vesa Ruotsalainen; Christer Holmberg; Riitta Karikoski; Riitta Salonen; Karl Tryggvason; Hannu Jalanko
Tissue expression of nephrin in human and pig.
Pediatric research 2004;55(5):774-81.
2004: Phan-Kiet Tran; Karin Tran-Lundmark; Raija Soininen; Karl Tryggvason; Johan Thyberg; Ulf Hedin
Increased intimal hyperplasia and smooth muscle cell proliferation in transgenic mice with heparan sulfate-deficient perlecan.
Circulation research 2004;94(4):550-8.
2004: Leah C Byrne; Zhongjun Zhou; Karl Tryggvason; Tomas Hökfelt; Sergueï O Fetissov
Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice.
Neuroreport 2004;15(3):569-74.
2004: Vesa Ruotsalainen; Paula Reponen; Jamshid Khoshnoodi; Pekka Kilpeläinen; Karl Tryggvason
Monoclonal antibodies to human nephrin.
Hybridoma and hybridomics 2004;23(1):55-63.
2004: Tuire M Salonurmi; Mataleena Parikka; Sirpa Kontusaari; Emma Pirilä; Carine Munaut; Tuula Salo; Karl Tryggvason
Overexpression of TIMP-1 under the MMP-9 promoter interferes with wound healing in transgenic mice.
Cell and tissue research 2004;315(1):27-37.
2003: Jamshid Khoshnoodi; Kristmundur Sigmundsson; Lars-Göran Ofverstedt; Ulf Skoglund; Björn Obrink; Jorma Wartiovaara; Karl Tryggvason
Nephrin promotes cell-cell adhesion through homophilic interactions.
The American journal of pathology 2003;163(6):2337-46.
2003: Jean-Philippe jais; bertrand knebelmann; Iannis Giatras; Mario De Marchi; Gianfranco Rizzoni; Alessandra Renieri; Manfred Weber; Oliver Gross; Kai-Olaf Netzer; Frances Flinter; Yves Pirson; Karin Dahan; Jörgen Wieslander; Ulf Persson; Karl Tryggvason; Paula Martin; Jens Michael Hertz; Cornelis Schröder; Marek Sanak; Maria Fernanda Carvalho; Juan Saus; Corinne Antignac; Hubert Smeets; Marie-Claire Gubler
X-linked Alport syndrome: natural history and genotype-phenotype correlations in girls and women belonging to 195 families: a "European Community Alport Syndrome Concerted Action" study.
Journal of the American Society of Nephrology : JASN 2003;14(10):2603-10.
2003: Karl Tryggvason; E Pettersson
Causes and consequences of proteinuria: the kidney filtration barrier and progressive renal failure.
Journal of internal medicine 2003;254(3):216-24.
2003: Juhani Lahdenperä; Pekka Kilpeläinen; Xiao Li Liu; Timo Pikkarainen; Paula Reponen; Vesa Ruotsalainen; Karl Tryggvason
Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases.
Kidney international 2003;64(2):404-13.
2003: Tracy L Adair-Kirk; Jeffrey J Atkinson; Thomas J Broekelmann; Masayuki Doi; Karl Tryggvason; Jeffrey H Miner; Robert P Mecham; Robert M Senior
A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):398-406.
2003: Billy G Hudson; Karl Tryggvason; Munirathinam Sundaramoorthy; Eric G Neilson
Alport's syndrome, Goodpasture's syndrome, and type IV collagen.
The New England journal of medicine 2003;348(25):2543-56.
2003: Olga Beltcheva; Sirpa Kontusaari; Sergueï O Fetissov; Heli Putaala; Pekka Kilpeläinen; Tomas Hökfelt; Karl Tryggvason
Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin.
Journal of the American Society of Nephrology : JASN 2003;14(2):352-8.
2003: Yu-Chen Gu; Jarkko Kortesmaa; Karl Tryggvason; Jenny Persson; Peter Ekblom; Sten Eirik W Jacobsen; Marja Ekblom
Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.
Blood 2003;101(3):877-85.
2003: Maarit Rossi; Hiroyuki Morita; Raija Sormunen; Sari Airenne; Marjut Kreivi; Ling Wang; Naomi Fukai; Bjorn R Olsen; Karl Tryggvason; Raija Soininen
Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney.
The EMBO journal 2003;22(2):236-45.
2003: John D Bartlett; Zhongjun Zhou; Ziedonis Skobe; Justine Dobeck; Karl Tryggvason
Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice.
Connective tissue research 2003;44 Suppl 1():300-4.
2003: Caroline Lundgren; Bo Frankendal; Claes Silfverswärd; Bo Nilsson; Karl Tryggvason; Gert Auer; Britta Nordström
Laminin-5 gamma2-chain expression and DNA ploidy as predictors of prognosis in endometrial carcinoma.
Medical oncology (Northwood, London, England) 2003;20(2):147-56.
2003: Annika Wernerson; Fredrik Dunér; Erna Pettersson; Silwa Mengarelli Widholm; Ulla Berg; Vesa Ruotsalainen; Karl Tryggvason; Kjell Hultenby; Magnus Söderberg
Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(1):70-6.
2002: Jarkko Kortesmaa; Masayuki Doi; Manuel Patarroyo; Karl Tryggvason
Chondroitin sulphate modification in the alpha4 chain of human recombinant laminin-8 (alpha4beta1gamma1).
Matrix biology : journal of the International Society for Matrix Biology 2002;21(6):483-6.
2002: Moin A Saleem; Lan Ni; Ian R Witherden; Karl Tryggvason; Vesa Ruotsalainen; Peter Mundel; Peter W Mathieson
Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation.
The American journal of pathology 2002;161(4):1459-66.
2002: Claus-Werner Franzke; Kaisa Tasanen; Heike Schäcke; Zhongjun Zhou; Karl Tryggvason; Cornelia Mauch; Paola Zigrino; Susan W Sunnarborg; David C Lee; Falk Fahrenholz; Leena Bruckner-Tuderman
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs.
The EMBO journal 2002;21(19):5026-35.
2002: Marko Sankala; Annika Brännström; Therese Schulthess; Ulrich Bergmann; Ekaterina Morgunova; Jürgen Engel; Karl Tryggvason; Timo Pikkarainen
Characterization of recombinant soluble macrophage scavenger receptor MARCO.
The Journal of biological chemistry 2002;277(36):33378-85.
2002: Noora Petäjäniemi; Matti Korhonen; Jarkko Kortesmaa; Karl Tryggvason; Kiyotoshi Sekiguchi; Hironobu Fujiwara; Lydia Sorokin; Lars-Eric Thornell; Zenebech Wondimu; Daniel Assefa; Manuel Patarroyo; Ismo Virtanen
Localization of laminin alpha4-chain in developing and adult human tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(8):1113-30.
2002: Manuel Patarroyo; Karl Tryggvason; Ismo Virtanen
Laminin isoforms in tumor invasion, angiogenesis and metastasis.
Seminars in cancer biology 2002;12(3):197-207.
2002: Ekaterina Morgunova; Ari Tuuttila; Ulrich Bergmann; Karl Tryggvason
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7414-9.
2002: Sergei P Smirnov; Erin L McDearmon; Shaohua Li; James M Ervasti; Karl Tryggvason; Peter D Yurchenco
Contributions of the LG modules and furin processing to laminin-2 functions.
The Journal of biological chemistry 2002;277(21):18928-37.
2002: Jaakko Patrakka; Paula Martin; Riitta Salonen; Marjo Kestilä; Vesa Ruotsalainen; Minna Männikkö; Markku Ryynänen; Juhani Rapola; Christer Holmberg; Karl Tryggvason; Hannu Jalanko
Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations.
Lancet 2002;359(9317):1575-7.
2002: Kunimasa Yan; Jamshid Khoshnoodi; Vesa Ruotsalainen; Karl Tryggvason
N-linked glycosylation is critical for the plasma membrane localization of nephrin.
Journal of the American Society of Nephrology : JASN 2002;13(5):1385-9.
2002: Alberto Pendas; Zhongjun Zhou; Juan Cadiñanos; José M P Freije; Jianming Wang; Kjell Hultenby; AURORA ASTUDILLO; Annika Wernerson; Francisco Rodríguez; Karl Tryggvason; Carlos López-Otín
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.
Nature genetics 2002;31(1):94-9.
2002: Masayuki Doi; Jill Thyboll; Jarkko Kortesmaa; Katarina Jansson; Antti Iivanainen; Masomeh Parvardeh; Rupert Timpl; Ulf Hedin; Jesper Swedenborg; Karl Tryggvason
Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells.
The Journal of biological chemistry 2002;277(15):12741-8.
2002: Wooseong Huh; Dae Joong Kim; Mi-Kyung Kim; Yoon-Goo Kim; Ha-Young Oh; Vesa Ruotsalainen; Karl Tryggvason
Expression of nephrin in acquired human glomerular disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17(3):478-84.
2002: Jaakko Patrakka; Vesa Ruotsalainen; Paula Reponen; Erik Qvist; Jarmo Laine; Christer Holmberg; Karl Tryggvason; Hannu Jalanko
Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrin.
Transplantation 2002;73(3):394-403.
2002: Ania Koziell; Victor Grech; Sagair Hussain; Gary Lee; Ulla Lenkkeri; Karl Tryggvason; Peter J Scambler
Genotype/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration.
Human molecular genetics 2002;11(4):379-88.
2002: Annika Brännström; Marko Sankala; Karl Tryggvason; Timo Pikkarainen
Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO.
Biochemical and biophysical research communications 2002;290(5):1462-9.
2002: Jill Thyboll; Jarkko Kortesmaa; Renhai Cao; Raija Soininen; Ling Wang; Antti Iivanainen; Lydia Sorokin; Mårten Risling; Yihai Cao; Karl Tryggvason
Deletion of the laminin alpha4 chain leads to impaired microvessel maturation.
Molecular and cellular biology 2002;22(4):1194-202.
2002: Britta Nordström; Nina Einhorn; Claes Silfverswärd; Kerstin Sjövall; Karl Tryggvason; Gert Auer
Laminin-5 gamma 2 chain as an invasivity marker for uni- and multifocal lesions in the lower anogenital tract.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2002;12(1):105-9.
2001: Tarak Srivastava; Joan M Whiting; Robert E Garola; Majed Dasouki; Vesa Ruotsalainen; Karl Tryggvason; R Hamed; Uri S Alon
Podocyte proteins in Galloway-Mowat syndrome.
Pediatric nephrology (Berlin, Germany) 2001;16(12):1022-9.
2001: Hannu Jalanko; Jaakko Patrakka; Karl Tryggvason; Christer Holmberg
Genetic kidney diseases disclose the pathogenesis of proteinuria.
Annals of medicine 2001;33(8):526-33.
2001: L Liu; Stefania Cotta Doné; Jamshid Khoshnoodi; Alejandro M Bertorello; Jorma Wartiovaara; Per-Olof Berggren; Karl Tryggvason
Defective nephrin trafficking caused by missense mutations in the NPHS1 gene: insight into the mechanisms of congenital nephrotic syndrome.
Human molecular genetics 2001;10(23):2637-44.
2001: Karl Tryggvason; Jorma Wartiovaara
Molecular basis of glomerular permselectivity.
Current opinion in nephrology and hypertension 2001;10(4):543-9.
2001: P Heikkilä; A Tibell; T Morita; Y Chen; G Wu; Y Sado; Y Ninomiya; E Pettersson; Karl Tryggvason
Adenovirus-mediated transfer of type IV collagen alpha5 chain cDNA into swine kidney in vivo: deposition of the protein into the glomerular basement membrane.
Gene therapy 2001;8(11):882-90.
2001: Jamshid Khoshnoodi; Karl Tryggvason
Congenital nephrotic syndromes.
Current opinion in genetics & development 2001;11(3):322-7.
2001: Bruce L Patton; J M Cunningham; Jill Thyboll; Jarkko Kortesmaa; H Westerblad; L Edström; Karl Tryggvason; Joshua R Sanes
Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4.
Nature neuroscience 2001;4(6):597-604.
2001: Sophie Doublier; Vesa Ruotsalainen; Gennaro Salvidio; Enrico Lupia; Livia Biancone; Pier Giulio Conaldi; Paula Reponen; Karl Tryggvason; Giovanni Camussi
Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome.
The American journal of pathology 2001;158(5):1723-31.
2001: O Beltcheva; P Martin; U Lenkkeri; Karl Tryggvason
Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome.
Human mutation 2001;17(5):368-73.
2001: Jaakko Patrakka; Vesa Ruotsalainen; Ilkka Ketola; Christer Holmberg; Markku Heikinheimo; Karl Tryggvason; Hannu Jalanko
Expression of nephrin in pediatric kidney diseases.
Journal of the American Society of Nephrology : JASN 2001;12(2):289-96.
2001: Jamshid Khoshnoodi; Karl Tryggvason
Unraveling the molecular make-up of the glomerular podocyte slit diaphragm.
Experimental nephrology 2001;9(6):355-9.
2001: P H Martin; Karl Tryggvason
Two novel alternatively spliced 9-bp exons in the COL4A5 gene.
Pediatric nephrology (Berlin, Germany) 2001;16(1):41-4.
2001: Heli Putaala; Raija Soininen; Pekka Kilpeläinen; Jorma Wartiovaara; Karl Tryggvason
The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death.
Human molecular genetics 2001;10(1):1-8.
2000: Vesa Ruotsalainen; Jaakko Patrakka; P Tissari; Paula Reponen; M Hess; Marjo Kestilä; Christer Holmberg; Riitta Salonen; Markku Heikinheimo; Jorma Wartiovaara; Karl Tryggvason; Hannu Jalanko
Role of nephrin in cell junction formation in human nephrogenesis.
The American journal of pathology 2000;157(6):1905-16.
2000: Claudio Pedraza; Tarekegn Geberhiwot; Sulev Ingerpuu; Daniel Assefa; Zenebech Wondimu; Jarkko Kortesmaa; Karl Tryggvason; Ismo Virtanen; Manuel Patarroyo
Monocytic cells synthesize, adhere to, and migrate on laminin-8 (alpha 4 beta 1 gamma 1).
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5831-8.
2000: Jaakko Patrakka; Marjo Kestilä; Jorma Wartiovaara; Vesa Ruotsalainen; P Tissari; U Lenkkeri; Minna Männikkö; Ilona Visapää; Christer Holmberg; Juhani Rapola; Karl Tryggvason; Hannu Jalanko
Congenital nephrotic syndrome (NPHS1): features resulting from different mutations in Finnish patients.
Kidney international 2000;58(3):972-80.
2000: P Martin; N Heiskari; H Pajari; C Grönhagen-Riska; Helena Kääriäinen; Olli Koskimies; Karl Tryggvason
Spectrum of COL4A5 mutations in Finnish Alport syndrome patients.
Human mutation 2000;15(6):579.
2000: Heli Putaala; Kirsi Sainio; Hannu Sariola; Karl Tryggvason
Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene.
Journal of the American Society of Nephrology : JASN 2000;11(6):991-1001.
2000: Jarkko Kortesmaa; P Yurchenco; Karl Tryggvason
Recombinant laminin-8 (alpha(4)beta(1)gamma(1)). Production, purification,and interactions with integrins.
The Journal of biological chemistry 2000;275(20):14853-9.
2000: Tarekegn Geberhiwot; Zenebech Wondimu; S Salo; T Pikkarainen; Jarkko Kortesmaa; Karl Tryggvason; Ismo Virtanen; Manuel Patarroyo
Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin beta1 and gamma1 chains.
Matrix biology : journal of the International Society for Matrix Biology 2000;19(2):163-7.
2000: Z Zhou; S S Apte; Raija Soininen; Renhai Cao; G Y Baaklini; R W Rauser; J Wang; Yihai Cao; Karl Tryggvason
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4052-7.
2000: Tomi T Airenne; Y Lin; M Olsson; P Ekblom; Seppo Vainio; Karl Tryggvason
Differential expression of mouse laminin gamma2 and gamma2* chain transcripts.
Cell and tissue research 2000;300(1):129-37.
2000: Jean-Philippe jais; bertrand knebelmann; I Giatras; Mario De Marchi; Gianfranco Rizzoni; Alessandra Renieri; M Weber; Oliver Gross; Kai-Olaf Netzer; Frances Flinter; Yves Pirson; C Verellen; Jörgen Wieslander; Ulf Persson; Karl Tryggvason; P Martin; Jens Michael Hertz; C Schröder; Marek Sanak; S Krejcova; M F Carvalho; Juan Saus; Corinne Antignac; H Smeets; Marie-Claire Gubler
X-linked Alport syndrome: natural history in 195 families and genotype- phenotype correlations in males.
Journal of the American Society of Nephrology : JASN 2000;11(4):649-57.
2000: Georg Kraal; Luc J van der Laan; Outi Elomaa; Karl Tryggvason
The macrophage receptor MARCO.
Microbes and infection / Institut Pasteur 2000;2(3):313-6.
2000: Tarekegn Geberhiwot; Sulev Ingerpuu; Claudio Pedraza; M Neira; Ismo Virtanen; Karl Tryggvason; Manuel Patarroyo
Erythromegakaryocytic cells synthesize laminin-8 (alpha4beta1gamma1).
Experimental cell research 2000;254(1):189-95.
2000: P Heikkilä; Karl Tryggvason; P Thorner
Animal models of Alport syndrome: advancing the prospects for effective human gene therapy.
Experimental nephrology 2000;8(1):1-7.
1999: Tarekegn Geberhiwot; Sulev Ingerpuu; Claudio Pedraza; M Neira; U Lehto; Ismo Virtanen; Jarkko Kortesmaa; Karl Tryggvason; E Engvall; Manuel Patarroyo
Blood platelets contain and secrete laminin-8 (alpha4beta1gamma1) and adhere to laminin-8 via alpha6beta1 integrin.
Experimental cell research 1999;253(2):723-32.
1999: Karl Tryggvason
Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm.
Journal of the American Society of Nephrology : JASN 1999;10(11):2440-5.
1999: Marko Määttä; Ylermi Soini; Paavo Pääkkö; Sirpa Salo; Karl Tryggvason; Helena Autio-Harmainen
Expression of the laminin gamma2 chain in different histological types of lung carcinoma. A study by immunohistochemistry and in situ hybridization.
The Journal of pathology 1999;188(4):361-8.
1999: Vesa Ruotsalainen; P Ljungberg; Jorma Wartiovaara; U Lenkkeri; Marjo Kestilä; Hannu Jalanko; Christer Holmberg; Karl Tryggvason
Nephrin is specifically located at the slit diaphragm of glomerular podocytes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7962-7.
1999: Ekaterina Morgunova; Ari Tuuttila; Ulrich Bergmann; M Isupov; Ylva Lindqvist; G Schneider; Karl Tryggvason
Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed.
Science (New York, N.Y.) 1999;284(5420):1667-70.
1999: Maarit Kangas; A Brännström; Outi Elomaa; Y Matsuda; RL Eddy; T B Shows; Karl Tryggvason
Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor.
Genomics 1999;58(1):82-9.
1999: Antti Iivanainen; T Morita; Karl Tryggvason
Molecular cloning and tissue-specific expression of a novel murine laminin gamma3 chain.
The Journal of biological chemistry 1999;274(20):14107-11.
1999: Aiyappa Palecanda; Joseph D Paulauskis; E Al-Mutairi; Amy Imrich; Guozhong Qin; H Suzuki; T Kodama; Karl Tryggvason; Henry Koziel; Lester Kobzik
Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles.
The Journal of experimental medicine 1999;189(9):1497-506.
1999: Timo Pikkarainen; Annika Brännström; Karl Tryggvason
Expression of macrophage MARCO receptor induces formation of dendritic plasma membrane processes.
The Journal of biological chemistry 1999;274(16):10975-82.
1999: Sirpa Salo; H Haakana; Sirpa Kontusaari; E Hujanen; T Kallunki; Karl Tryggvason
Laminin-5 promotes adhesion and migration of epithelial cells: identification of a migration-related element in the gamma2 chain gene (LAMC2) with activity in transgenic mice.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(2):197-210.
1999: Carin Sahlberg; Paula Reponen; Karl Tryggvason; Irma Thesleff
Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis.
European journal of oral sciences 1999;107(2):121-30.
1999: Carine Munaut; Tuire M Salonurmi; Sirpa Kontusaari; P Reponen; T Morita; Jean-Michel Foidart; Karl Tryggvason
Murine matrix metalloproteinase 9 gene. 5'-upstream region contains cis-acting elements for expression in osteoclasts and migrating keratinocytes in transgenic mice.
The Journal of biological chemistry 1999;274(9):5588-96.
1999: Luc J van der Laan; Ed A Döpp; R Haworth; Timo Pikkarainen; Maarit Kangas; Outi Elomaa; Christine D Dijkstra; Siamon Gordon; Karl Tryggvason; Georg Kraal
Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):939-47.
1999: Karl Tryggvason; Vesa Ruotsalainen; Jorma Wartiovaara
Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney.
The International journal of developmental biology 1999;43(5):445-51.
1999: U Lenkkeri; Minna Männikkö; P McCready; Jane Lamerdin; O Gribouval; P M Niaudet; K Antignac C; C E Kashtan; C Homberg; A Olsen; Marjo Kestilä; Karl Tryggvason
Structure of the gene for congenital nephrotic syndrome of the finnish type (NPHS1) and characterization of mutations.
American journal of human genetics 1999;64(1):51-61.
1998: Ari Tuuttila; Ekaterina Morgunova; Ulrich Bergmann; Ylva Lindqvist; Klaus Maskos; Carlos Fernandez-Catalan; Wolfram Bode; Karl Tryggvason; Gunter Schneider
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution.
Journal of molecular biology 1998;284(4):1133-40.
1998: P Martin; N Heiskari; J Zhou; A Leinonen; T Tumelius; J M Hertz; D Barker; M Gregory; C Atkin; Unnur Styrkarsdottir; H Neumann; J Springate; T Shows; E Pettersson; Karl Tryggvason
High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing.
Journal of the American Society of Nephrology : JASN 1998;9(12):2291-301.
1998: Marjo Kestilä; U Lenkkeri; Minna Männikkö; Jane Lamerdin; P McCready; H Putaala; Vesa Ruotsalainen; T Morita; Marja Nissinen; Riitta Herva; C E Kashtan; Leena Peltonen; Christer Holmberg; A Olsen; Karl Tryggvason
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome.
Molecular cell 1998;1(4):575-82.
1998: Outi Elomaa; Marko Sankala; Timo Pikkarainen; Ulrich Bergmann; Ari Tuuttila; AM Raatikainen-Ahokas; Hannu Sariola; Karl Tryggvason
Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region.
The Journal of biological chemistry 1998;273(8):4530-8.
1998: U Lenkkeri; Marjo Kestilä; Jane Lamerdin; P McCready; A Adamson; A Olsen; Karl Tryggvason
Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1.
Human genetics 1998;102(2):192-6.
1997: Antti Iivanainen; Jarkko Kortesmaa; C Sahlberg; T Morita; Ulrich Bergmann; I Thesleff; Karl Tryggvason
Primary structure, developmental expression, and immunolocalization of the murine laminin alpha4 chain.
The Journal of biological chemistry 1997;272(44):27862-8.
1997: Pierre Dehan; David Waltregny; Alain Beschin; Agnès Noel; Vincent Castronovo; Karl Tryggvason; Jean de Leval; Jean-Michel Foidart
Loss of type IV collagen alpha 5 and alpha 6 chains in human invasive prostate carcinomas.
The American journal of pathology 1997;151(4):1097-104.
1997: Luc J van der Laan; Maarit Kangas; Ed A Döpp; E Broug-Holub; Outi Elomaa; Karl Tryggvason; Georg Kraal
Macrophage scavenger receptor MARCO: in vitro and in vivo regulation and involvement in the anti-bacterial host defense.
Immunology letters 1997;57(1-3):203-8.
1997: Karl Tryggvason; P Heikkilä; E Pettersson; A Tibell; P Thorner
Can Alport syndrome be treated by gene therapy?
Kidney international 1997;51(5):1493-9.
1997: Minna Männikkö; Marjo Kestilä; U Lenkkeri; H Alakurtti; Christer Holmberg; Jaakko Leisti; Riitta Salonen; P Aula; A Mustonen; Leena Peltonen; Karl Tryggvason
Improved prenatal diagnosis of the congenital nephrotic syndrome of the Finnish type based on DNA analysis.
Kidney international 1997;51(3):868-72.
1996: Minna Männikkö; U Lenkkeri; C E Kashtan; Marjo Kestilä; Christer Holmberg; Karl Tryggvason
Haplotype analysis of congenital nephrotic syndrome of the Finnish type in non-Finnish families.
Journal of the American Society of Nephrology : JASN 1996;7(12):2700-3.
1996: Ylermi Soini; M Määttä; Sirpa Salo; Karl Tryggvason; Helena Autio-Harmainen
Expression of the laminin gamma 2 chain in pancreatic adenocarcinoma.
The Journal of pathology 1996;180(3):290-4.
1996: P Dehan; M Weber; X Zhang; S T Reeders; J M Foidart; Karl Tryggvason
Sera from patients with anti-GBM nephritis including goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen alpha chains.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11(11):2215-22.
1996: X Zhang; R Vuolteenaho; Karl Tryggvason
Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy.
The Journal of biological chemistry 1996;271(44):27664-9.
1996: P Dehan; L P Van den Heuvel; H J Smeets; Karl Tryggvason; J M Foidart
Identification of post-transplant anti-alpha 5 (IV) collagen alloantibodies in X-linked Alport syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11(10):1983-8.
1996: M Nissinen; AH Helbling-Leclerc; X Zhang; T Evangelista; Haluk Topaloglu; C Cruaud; Jean Weissenbach; M Fardeau; Fernando M S Tomé; Ketty Schwartz; Karl Tryggvason; Pascale Guicheney
Substitution of a conserved cysteine-996 in a cysteine-rich motif of the laminin alpha2-chain in congenital muscular dystrophy with partial deficiency of the protein.
American journal of human genetics 1996;58(6):1177-84.
1996: N Heiskari; X Zhang; J Zhou; A Leinonen; D Barker; M Gregory; CL Atkin; Kai-Olaf Netzer; M Weber; S Reeders; C Grönhagen-Riska; H P Neumann; R Trembath; Karl Tryggvason
Identification of 17 mutations in ten exons in the COL4A5 collagen gene, but no mutations found in four exons in COL4A6: a study of 250 patients with hematuria and suspected of having Alport syndrome.
Journal of the American Society of Nephrology : JASN 1996;7(5):702-9.
1996: X Zhang; J Zhou; S T Reeders; Karl Tryggvason
Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis.
Genomics 1996;33(3):473-9.
1996: T Airenne; H Haakana; K Sainio; T Kallunki; P Kallunki; H Sariola; Karl Tryggvason
Structure of the human laminin gamma 2 chain gene (LAMC2): alternative splicing with different tissue distribution of two transcripts.
Genomics 1996;32(1):54-64.
1996: P Heikkila; T Parpala; O Lukkarinen; M Weber; Karl Tryggvason
Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system - first steps towards gene therapy of Alport syndrome.
Gene therapy 1996;3(1):21-7.
1996: Karl Tryggvason
Mutations in type IV collagen genes and Alport phenotypes.
Contributions to nephrology 1996;117():154-71.
1996: H Sariola; S L Hostikka; S Lukkarila; Karl Tryggvason
Distribution of type IV collagen alpha 1, alpha 2 and alpha 5 chains in human tissues.
Contributions to nephrology 1996;117():130-41.
1995: Minna Männikkö; M Kestailä; Christer Holmberg; R Norio; M Ryynänen; A Olsen; Leena Peltonen; Karl Tryggvason
Fine mapping and haplotype analysis of the locus for congenital nephrotic syndrome on chromosome 19q13.1.
American journal of human genetics 1995;57(6):1377-83.
1995: AH Helbling-Leclerc; X Zhang; Haluk Topaloglu; C Cruaud; Frédérique Tesson; Jean Weissenbach; Fernando M S Tomé; Ketty Schwartz; M Fardeau; Karl Tryggvason
Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy.
Nature genetics 1995;11(2):216-8.
1995: A Iivanainen; K Sainio; H Sariola; Karl Tryggvason
Primary structure and expression of a novel human laminin alpha 4 chain.
FEBS letters 1995;365(2-3):183-8.
1995: P Reponen; I Leivo; Carin Sahlberg; S S Apte; Bjorn R Olsen; Irma Thesleff; Karl Tryggvason
92-kDa type IV collagenase and TIMP-3, but not 72-kDa type IV collagenase or TIMP-1 or TIMP-2, are highly expressed during mouse embryo implantation.
Developmental dynamics : an official publication of the American Association of Anatomists 1995;202(4):388-96.
1995: Ulrich Bergmann; Ari Tuuttila; William Stetler-Stevenson; Karl Tryggvason
Autolytic activation of recombinant human 72 kilodalton type IV collagenase.
Biochemistry 1995;34(9):2819-25.
1995: Outi Elomaa; Maarit Kangas; Carin Sahlberg; Juha Tuukkanen; Raija Sormunen; A Liakka; Irma Thesleff; Georg Kraal; Karl Tryggvason
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages.
Cell 1995;80(4):603-9.
1995: A Iivanainen; R Vuolteenaho; K Sainio; R Eddy; TB Shows; H Sariola; Karl Tryggvason
The human laminin beta 2 chain (S-laminin): structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene.
Matrix biology : journal of the International Society for Matrix Biology 1995;14(6):489-97.
1995: Jens Michael Hertz; N Heiskari; J Zhou; U B Jensen; Karl Tryggvason
A nonsense mutation in the COL4A5 collagen gene in a family with X-linked juvenile Alport syndrome.
Kidney international 1995;47(1):327-32.
1994: P Reponen; Carin Sahlberg; Carine Munaut; Irma Thesleff; Karl Tryggvason
High expression of 92-kDa type IV collagenase (gelatinase) in the osteoclast lineage during mouse development.
Annals of the New York Academy of Sciences 1994;732():472-5.
1994: Carine Munaut; P Reponen; P Huhtala; Sirpa Kontusaari; J M Foidart; Karl Tryggvason
Structure of the mouse 92-kDa type IV collagenase gene. In vitro and in vivo expression in transient transfection studies and transgenic mice.
Annals of the New York Academy of Sciences 1994;732():369-71.
1994: E S Hujanen; A Väisänen; Aiping Zheng; Karl Tryggvason; Taina Turpeenniemi-Hujanen
Modulation of M(r) 72,000 and M(r) 92,000 type-IV collagenase (gelatinase A and B) gene expression by interferons alpha and gamma in human melanoma.
International journal of cancer. Journal international du cancer 1994;58(4):582-6.
1994: Marjo Kestilä; Minna Männikkö; Christer Holmberg; G Gyapay; Jean Weissenbach; E R Savolainen; Leena Peltonen; Karl Tryggvason
Congenital nephrotic syndrome of the Finnish type maps to the long arm of chromosome 19.
American journal of human genetics 1994;54(5):757-64.
1994: Marjo Kestilä; Minna Männikkö; Christer Holmberg; K Korpela; E R Savolainen; Leena Peltonen; Karl Tryggvason
Exclusion of eight genes as mutated loci in congenital nephrotic syndrome of the Finnish type.
Kidney international 1994;45(4):986-90.
1994: J Zhou; A Leinonen; Karl Tryggvason
Structure of the human type IV collagen COL4A5 gene.
The Journal of biological chemistry 1994;269(9):6608-14.
1994: P Reponen; Carin Sahlberg; Carine Munaut; Irma Thesleff; Karl Tryggvason
High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development.
The Journal of cell biology 1994;124(6):1091-1102.
1994: L Pulkkinen; Angela M Christiano; T Airenne; H Haakana; Karl Tryggvason; J Uitto
Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa.
Nature genetics 1994;6(3):293-7.
1994: R Vuolteenaho; M Nissinen; K Sainio; M Byers; R Eddy; H Hirvonen; TB Shows; H Sariola; E Engvall; Karl Tryggvason
Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues.
The Journal of cell biology 1994;124(3):381-94.
1994: Marjo Kestilä; Minna Männikkö; Christer Holmberg; Karl Tryggvason; Leena Peltonen
Congenital nephrotic syndrome of the Finnish type is not associated with the Pax-2 gene despite the promising transgenic animal model.
Genomics 1994;19(3):570-2.
1993: P Heikkilä; R Soininen; Karl Tryggvason
Directional regulatory activity of cis-acting elements in the bidirectional alpha 1(IV) and alpha 2(IV) collagen gene promoter.
The Journal of biological chemistry 1993;268(33):24677-82.
1993: Helena Autio-Harmainen; T Karttunen; Tiina Hurskainen; M Höyhtyä; Antti Kauppila; Karl Tryggvason
Expression of 72 kilodalton type IV collagenase (gelatinase A) in benign and malignant ovarian tumors.
Laboratory investigation; a journal of technical methods and pathology 1993;69(3):312-21.
1993: Karl Tryggvason
Biochemistry and genetic diseases of glomerular basement membrane.
Seminars in nephrology 1993;13(5):447-56.
1993: J Zhou; Martin C Gregory; Jens Michael Hertz; David Barker; CL Atkin; E S Spencer; Karl Tryggvason
Mutations in the codon for a conserved arginine-1563 in the COL4A5 collagen gene in Alport syndrome.
Kidney international 1993;43(3):722-9.
1993: Kai-Olaf Netzer; oliver pullig; U Frei; J Zhou; Karl Tryggvason; M Weber
COL4A5 splice site mutation and alpha 5(IV) collagen mRNA in Alport syndrome.
Kidney international 1993;43(2):486-92.
1993: Karl Tryggvason; M Höyhtyä; C Pyke
Type IV collagenases in invasive tumors.
Breast cancer research and treatment 1993;24(3):209-18.
1993: Karl Tryggvason; J Zhou; S L Hostikka; TB Shows
Molecular genetics of Alport syndrome.
Kidney international 1993;43(1):38-44.
1993: Karl Tryggvason; J Zhou; S L Hostikka; H Sariola
Type IV collagen in normal and diseased glomerular basement membrane.
Advances in nephrology from the Necker Hospital 1993;22():1-14.
1992: Kai-Olaf Netzer; Lutz Renders; J Zhou; oliver pullig; Karl Tryggvason; M Weber
Deletions of the COL4A5 gene in patients with Alport syndrome.
Kidney international 1992;42(6):1336-44.
1992: Carin Sahlberg; P Reponen; Karl Tryggvason; Irma Thesleff
Association between the expression of murine 72 kDa type IV collagenase by odontoblasts and basement membrane degradation during mouse tooth development.
Archives of oral biology 1992;37(12):1021-30.
1992: P Kallunki; K Sainio; R Eddy; M Byers; T Kallunki; H Sariola; K Beck; H Hirvonen; TB Shows; Karl Tryggvason
A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment.
The Journal of cell biology 1992;119(3):679-93.
1992: T Pikkarainen; T Schulthess; J Engel; Karl Tryggvason
Recombinant laminin B1 chains exhibit intact short-arm domains but do not form oligomeric molecules.
European journal of biochemistry / FEBS 1992;209(2):571-82.
1992: Jorma Keski-Oja; Jouko Lohi; Ari Tuuttila; Karl Tryggvason; T Vartio
Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator.
Experimental cell research 1992;202(2):471-6.
1992: Helena Autio-Harmainen; Tiina Hurskainen; K Niskasaari; M Höyhtyä; Karl Tryggvason
Simultaneous expression of 70 kilodalton type IV collagenase and type IV collagen alpha 1 (IV) chain genes by cells of early human placenta and gestational endometrium.
Laboratory investigation; a journal of technical methods and pathology 1992;67(2):191-200.
1992: J Zhou; Jens Michael Hertz; A Leinonen; Karl Tryggvason
Complete amino acid sequence of the human alpha 5 (IV) collagen chain and identification of a single-base mutation in exon 23 converting glycine 521 in the collagenous domain to cysteine in an Alport syndrome patient.
The Journal of biological chemistry 1992;267(18):12475-81.
1992: J Zhou; Jens Michael Hertz; Karl Tryggvason
Mutation in the alpha 5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss or ocular lesions: detection by denaturing gradient gel electrophoresis of a PCR product.
American journal of human genetics 1992;50(6):1291-300.
1992: P Reponen; Carin Sahlberg; P Huhtala; Tiina Hurskainen; Irma Thesleff; Karl Tryggvason
Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development.
The Journal of biological chemistry 1992;267(11):7856-62.
1992: C Pyke; E Ralfkiaer; P Huhtala; Tiina Hurskainen; K Danø; Karl Tryggvason
Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.
Cancer research 1992;52(5):1336-41.
1992: P Kallunki; Karl Tryggvason
Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
The Journal of cell biology 1992;116(2):559-71.
1992: P Huhtala; L Chow; TB Shows; Karl Tryggvason
Structure of the human 70 K type IV collagenase gene and assignment of the gene to the q21 region of chromosome 16.
Matrix (Stuttgart, Germany). Supplement 1992;1():84.
1992: Karl Tryggvason; P Huhtala; M Höyhtya; E Hujanen; Tiina Hurskainen
70 K type IV collagenase (gelatinase).
Matrix (Stuttgart, Germany). Supplement 1992;1():45-50.
1991: David Barker; P R Fain; David E Goldgar; J N Dietz-Band; A E Turco; Clifford E Kashtan; Martin C Gregory; Karl Tryggvason; Mark H Skolnick; CL Atkin
High-density genetic and physical mapping of DNA markers near the X-linked Alport syndrome locus: definition and use of flanking polymorphic markers.
Human genetics 1991;88(2):189-94.
1991: P Kallunki; R L Eddy; M G Byers; Marjo Kestilä; TB Shows; Karl Tryggvason
Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1----p35 and identification of a BamHI restriction fragment length polymorphism.
Genomics 1991;11(2):389-96.
1991: L Tikka; Outi Elomaa; Taina Pihlajaniemi; Karl Tryggvason
Human alpha 1 (XIII) collagen gene. Multiple forms of the gene transcripts are generated through complex alternative splicing of several short exons.
The Journal of biological chemistry 1991;266(26):17713-9.
1991: P Huhtala; Ari Tuuttila; L T Chow; Jouko Lohi; Jorma Keski-Oja; Karl Tryggvason
Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells.
The Journal of biological chemistry 1991;266(25):16485-90.
1991: Karl Tryggvason
Cloning of Alport syndrome gene.
Annals of medicine 1991;23(3):237-9.
1991: M Nissinen; R Vuolteenaho; R Boot-Handford; P Kallunki; Karl Tryggvason
Primary structure of the human laminin A chain. Limited expression in human tissues.
The Biochemical journal 1991;276 ( Pt 2)():369-79.
1991: T Kallunki; J Ikonen; L T Chow; P Kallunki; Karl Tryggvason
Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene.
The Journal of biological chemistry 1991;266(1):221-8.
1991: J Zhou; S L Hostikka; L T Chow; Karl Tryggvason
Characterization of the 3' half of the human type IV collagen alpha 5 gene that is affected in the Alport syndrome.
Genomics 1991;9(1):1-9.
1991: J Zhou; David Barker; S L Hostikka; Martin C Gregory; CL Atkin; Karl Tryggvason
Single base mutation in alpha 5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome.
Genomics 1991;9(1):10-8.
1990: Karl Tryggvason; P Huhtala; Ari Tuuttila; L Chow; Jorma Keski-Oja; Jouko Lohi
Structure and expression of type IV collagenase genes.
Cell differentiation and development : the official journal of the International Society of Developmental Biologists 1990;32(3):307-12.
1990: R Vuolteenaho; L T Chow; Karl Tryggvason
Structure of the human laminin B1 chain gene.
The Journal of biological chemistry 1990;265(26):15611-6.
1990: M Höyhtyä; E Hujanen; Taina Turpeenniemi-Hujanen; U Thorgeirsson; L A Liotta; Karl Tryggvason
Modulation of type-IV collagenase activity and invasive behavior of metastatic human melanoma (A2058) cells in vitro by monoclonal antibodies to type-IV collagenase.
International journal of cancer. Journal international du cancer 1990;46(2):282-6.
1990: P Huhtala; L T Chow; Karl Tryggvason
Structure of the human type IV collagenase gene.
The Journal of biological chemistry 1990;265(19):11077-82.
1990: David Barker; S L Hostikka; J Zhou; L T Chow; A R Oliphant; S C Gerken; Martin C Gregory; Mark H Skolnick; CL Atkin; Karl Tryggvason
Identification of mutations in the COL4A5 collagen gene in Alport syndrome.
Science (New York, N.Y.) 1990;248(4960):1224-7.
1990: P Huhtala; R L Eddy; Yao-Shan Fan; M G Byers; TB Shows; Karl Tryggvason
Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16.
Genomics 1990;6(3):554-9.
1990: S L Hostikka; R L Eddy; M G Byers; M Höyhtyä; TB Shows; Karl Tryggvason
Identification of a distinct type IV collagen alpha chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1606-10.
1990: Karl Tryggvason; R Soininen; S L Hostikka; A Ganguly; M Huotari; Darwin J Prockop
Structure of the human type IV collagen genes.
Annals of the New York Academy of Sciences 1990;580():97-111.
1989: R Soininen; M Huotari; A Ganguly; Darwin J Prockop; Karl Tryggvason
Structural organization of the gene for the alpha 1 chain of human type IV collagen.
The Journal of biological chemistry 1989;264(23):13565-71.
1989: TB Shows; L Tikka; M G Byers; R L Eddy; L L Haley; W M Henry; D J Prockop; Karl Tryggvason
Assignment of the human collagen alpha 1 (XIII) chain gene (COL13A1) to the q22 region of chromosome 10.
Genomics 1989;5(1):128-33.
1989: T Kallunki; T Pikkarainen; Karl Tryggvason; E R Savolainen
A Pst I polymorphism in the human laminin B2 chain gene on 1q25-q31.
Nucleic acids research 1989;17(11):4423.
1989: T Pikkarainen; E R Savolainen; Karl Tryggvason
Nhe I and Hinc II polymorphisms in the human laminin B1 chain gene on 7q22.
Nucleic acids research 1989;17(11):4424.
1989: J Ikonen; T Pikkarainen; E R Savolainen; Karl Tryggvason
A Hpa I polymorphism in the human laminin B1 chain gene on 7q22.
Nucleic acids research 1989;17(1):473.
1988: S L Hostikka; Karl Tryggvason
The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain.
The Journal of biological chemistry 1988;263(36):19488-93.
1988: R Soininen; M Huotari; S L Hostikka; Darwin J Prockop; Karl Tryggvason
The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.
The Journal of biological chemistry 1988;263(33):17217-20.
1988: L Tikka; Taina Pihlajaniemi; P Henttu; Darwin J Prockop; Karl Tryggvason
Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7491-5.
1988: M Höyhtyä; Taina Turpeenniemi-Hujanen; W Stetler-Stevenson; H Krutzsch; Karl Tryggvason; L A Liotta
Monoclonal antibodies to type IV collagenase recognize a protein with limited sequence homology to interstitial collagenase and stromelysin.
FEBS letters 1988;233(1):109-13.
1988: T Pikkarainen; T Kallunki; Karl Tryggvason
Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains.
The Journal of biological chemistry 1988;263(14):6751-8.
1988: Y Fukushima; T Pikkarainen; T Kallunki; R L Eddy; M G Byers; L L Haley; W M Henry; Karl Tryggvason; TB Shows
Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment of the gene to chromosome region 1q25----q31.
Cytogenetics and cell genetics 1988;48(3):137-41.
1987: R Soininen; T Haka-Risku; Darwin J Prockop; Karl Tryggvason
Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen.
FEBS letters 1987;225(1-2):188-94.
1987: S L Hostikka; Karl Tryggvason
Extensive structural differences between genes for the alpha 1 and alpha 2 chains of type IV collagen despite conservation of coding sequences.
FEBS letters 1987;224(2):297-305.
1987: Karl Tryggvason; M Höyhtyä; Tuula Salo
Proteolytic degradation of extracellular matrix in tumor invasion.
Biochimica et biophysica acta 1987;907(3):191-217.
1987: T Pikkarainen; R Eddy; Y Fukushima; M Byers; TB Shows; T Pihlajaniemi; M Saraste; Karl Tryggvason
Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7.
The Journal of biological chemistry 1987;262(22):10454-62.
1987: L Tikka; K Roiko; R Soininen; Darwin J Prockop; Karl Tryggvason
A HindIII polymorphism in the 3' end of the human alpha 1(IV) collagen gene.
Nucleic acids research 1987;15(13):5497.
1987: Aarne Oikarinen; Tuula Salo; Leena Ala-Kokko; Karl Tryggvason
Dexamethasone modulates the metabolism of type IV collagen and fibronectin in human basement-membrane-forming fibrosarcoma (HT-1080) cells.
The Biochemical journal 1987;245(1):235-41.
1986: R Soininen; L Chow; Markku T Kurkinen; Karl Tryggvason; Darwin J Prockop
The gene for the alpha 1(IV) chain of human type IV procollagen: the exon structures do not coincide with the two structural subdomains in the globular carboxy-terminus of the protein.
The EMBO journal 1986;5(11):2821-3.
1986: R Soininen; L Tikka; L Chow; Taina Pihlajaniemi; Markku T Kurkinen; Darwin J Prockop; C D Boyd; Karl Tryggvason
Large introns in the 3' end of the gene for the pro alpha 1 (IV) chain of human basement membrane collagen.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1568-72.