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Ah-Lim Tsai
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34
Kulmacz, Richard
22
Berka, Vladimir
15
Wu, Kenneth
13
Palmer, Graham
10
Wang, Lee-Ho
10
Wu, Gang
8
Rogge, Corina
8
Chen, Pei-Feng
7
Liu, Wen
7
Yeh, Hui-Chun
5
van der Donk, Wilfred
5
Hsu, Pei-Yung
3
Okeley, Nicole
3
Lambry, Jean-Christophe
3
Gerfen, Gary
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All Publications
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2009: Rogge Corina E; Liu Wen; Kulmacz Richard J; Tsai Ah-Lim
Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1.
Journal of inorganic biochemistry 2009;103(6):912-22.
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2009: Yeh Hui-Chun; Gerfen Gary J; Wang Jinn-Shyan; Tsai Ah-Lim; Wang Lee-Ho
Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate.
Biochemistry 2009;48(5):917-28.
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2008: Liu Wen; Rogge Corina E; da Silva Giordano F Z; Shinkarev Vladimir P; Tsai Ah-Lim; Kamensky Yury; Palmer Graham; Kulmacz Richard J
His92 and His110 selectively affect different heme centers of adrenal cytochrome b(561).
Biochimica et biophysica acta 2008;1777(9):1218-28.
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2008: Yeh Hui-Chun; Hsu Pei-Yung; Tsai Ah-Lim; Wang Lee-Ho
Spectroscopic characterization of the oxyferrous complex of prostacyclin synthase in solution and in trapped sol-gel matrix.
The FEBS journal 2008;275(9):2305-14.
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2008: Berka Vladimír; Wang Lee-Ho; Tsai Ah-Lim
Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol.
Biochemistry 2008;47(1):405-20.
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2007: Liu Wen; Rogge Corina E; Kamensky Yury; Tsai Ah-Lim; Kulmacz Richard J
Development of a bacterial system for high yield expression of fully functional adrenal cytochrome b561.
Protein expression and purification 2007;56(2):145-52.
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2007: Kamensky Yury; Liu Wen; Tsai Ah-Lim; Kulmacz Richard J; Palmer Graham
Axial ligation and stoichiometry of heme centers in adrenal cytochrome b561.
Biochemistry 2007;46(29):8647-58.
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2007: Sasaki Jun; Phillips Brian J; Chen Xinpu; Van Eps Ned; Tsai Ah-Lim; Hubbell Wayne L; Spudich John L
Different dark conformations function in color-sensitive photosignaling by the sensory rhodopsin I-HtrI complex.
Biophysical journal 2007;92(11):4045-53.
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2007: Yeh Hui-Chun; Tsai Ah-Lim; Wang Lee-Ho
Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases.
Archives of biochemistry and biophysics 2007;461(2):159-68.
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2007: Beaumont Edward; Lambry Jean-Christophe; Gautier Clément; Robin Anne-Claire; Gmouh Said; Berka Vladimir; Tsai Ah-Lim; Blanchard-Desce Mireille; Slama-Schwok Anny
Synchronous photoinitiation of endothelial NO synthase activity by a nanotrigger targeted at its NADPH site.
Journal of the American Chemical Society 2007;129(7):2178-86.
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2007: Wu Gang; Rogge Corina E; Wang Jinn-Shyan; Kulmacz Richard J; Palmer Graham; Tsai Ah-Lim
Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation.
Biochemistry 2007;46(2):534-42.
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2007: Cardounel Arturo J; Cui Hongmei; Samouilov Alexandre; Johnson Wesley; Kearns Patrick; Tsai Ah-Lim; Berka Vladomir; Zweier Jay L
Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function.
The Journal of biological chemistry 2007;282(2):879-87.
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2006: Martin Emil; Berka Vladimir; Bogatenkova Elena; Murad Ferid; Tsai Ah-Lim
Ligand selectivity of soluble guanylyl cyclase: effect of the hydrogen-bonding tyrosine in the distal heme pocket on binding of oxygen, nitric oxide, and carbon monoxide.
The Journal of biological chemistry 2006;281(38):27836-45.
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2006: Rogge Corina E; Ho Bryant; Liu Wen; Kulmacz Richard J; Tsai Ah-Lim
Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2.
Biochemistry 2006;45(2):523-32.
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2005: Yeh Hui-Chun; Hsu Pei-Yung; Wang Jinn-Shyan; Tsai Ah-Lim; Wang Lee-Ho
Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase.
Biochimica et biophysica acta 2005;1738(1-3):121-32.
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2005: Wilson John C; Wu Gang; Tsai Ah-lim; Gerfen Gary J
Determination of the structural environment of the tyrosyl radical in prostaglandin H2 synthase-1: a high frequency ENDOR/EPR study.
Journal of the American Chemical Society 2005;127(6):1618-9.
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2005: Lowe Ezra R; Everett Andrew C; Lee Anthony J; Lau Miranda; Dunbar Anwar Y; Berka Vladimir; Tsai Ah-Lim; Osawa Yoichi
Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(1):131-8.
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2005: Martin Emil; Berka Vladimir; Tsai Ah-Lim; Murad Ferid
Soluble guanylyl cyclase: the nitric oxide receptor.
Methods in enzymology 2005;396():478-92.
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2004: Nioche Pierre; Berka Vladimir; Vipond Julia; Minton Nigel; Tsai Ah-Lim; Raman C S
Femtomolar sensitivity of a NO sensor from Clostridium botulinum.
Science (New York, N.Y.) 2004;306(5701):1550-3.
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2004: Berka Vladimir; Yeh Hui-Chun; Gao De; Kiran Farheen; Tsai Ah-Lim
Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase.
Biochemistry 2004;43(41):13137-48.
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2004: Berka Vladimir; Wu Gang; Yeh Hui-Chun; Palmer Graham; Tsai Ah-lim
Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin.
The Journal of biological chemistry 2004;279(31):32243-51.
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2004: Liu Wen; Rogge Corina E; Bambai Bijan; Palmer Graham; Tsai Ah-Lim; Kulmacz Richard J
Characterization of the heme environment in Arabidopsis thaliana fatty acid alpha-dioxygenase-1.
The Journal of biological chemistry 2004;279(28):29805-15.
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2004: Olson John S; Foley Erin W; Rogge Corina; Tsai Ah-Lim; Doyle Michael P; Lemon Douglas D
No scavenging and the hypertensive effect of hemoglobin-based blood substitutes.
Free radical biology & medicine 2004;36(6):685-97.
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2004: Rogge Corina E; Liu Wen; Wu Gang; Wang Lee-Ho; Kulmacz Richard J; Tsai Ah-Lim
Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.
Biochemistry 2004;43(6):1560-8.
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2003: Hu Guanghui; Tsai Ah-Lim; Quiocho Florante A
Insertion of an N7-methylguanine mRNA cap between two coplanar aromatic residues of a cap-binding protein is fast and selective for a positively charged cap.
The Journal of biological chemistry 2003;278(51):51515-20.
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2003: Wu Gang; Kulmacz Richard J; Tsai Ah-Lim
Cyclooxygenase inactivation kinetics during reaction of prostaglandin H synthase-1 with peroxide.
Biochemistry 2003;42(46):13772-7.
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2003: Kulmacz Richard J; van der Donk Wilfred A; Tsai Ah-Lim
Comparison of the properties of prostaglandin H synthase-1 and -2.
Progress in lipid research 2003;42(5):377-404.
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2003: Du Mei; Yeh Hui-Chun; Berka Vladimir; Wang Lee-Ho; Tsai Ah-Lim
Redox properties of human endothelial nitric-oxide synthase oxygenase and reductase domains purified from yeast expression system.
The Journal of biological chemistry 2003;278(8):6002-11.
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2002: van der Donk Wilfred A; Tsai Ah-Lim; Kulmacz Richard J
The cyclooxygenase reaction mechanism.
Biochemistry 2002;41(52):15451-8.
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2002: Tsai Ah-lim; Palmer Graham; Wu Gang; Peng Sheng; Okeley Nicole M; van der Donk Wilfred A; Kulmacz Richard J
Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2.
The Journal of biological chemistry 2002;277(41):38311-21.
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2002: Peng Sheng; Okeley Nicole M; Tsai Ah-Lim; Wu Gang; Kulmacz Richard J; van der Donk Wilfred A
Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase.
Journal of the American Chemical Society 2002;124(36):10785-96.
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2002: Dorlet Pierre; Seibold Steve A; Babcock Gerald T; Gerfen Gary J; Smith William L; Tsai Ah-lim; Un Sun
High-field EPR study of tyrosyl radicals in prostaglandin H(2) synthase-1.
Biochemistry 2002;41(19):6107-14.
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2002: Schelvis Johannes P M; Berka Vladimir; Babcock Gerald T; Tsai Ah-Lim
Resonance Raman detection of the Fe-S bond in endothelial nitric oxide synthase.
Biochemistry 2002;41(18):5695-701.
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2002: Slama-Schwok Anny; Négrerie Michel; Berka Vladimir; Lambry Jean-Christophe; Tsai Ah-Lim; Vos Marten H; Martin Jean-Louis
Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin?
The Journal of biological chemistry 2002;277(9):7581-6.
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2002: Kanaya Koichi; Tsai Ah-Lim; Kamitani Tetsu
Cobalt- and nickel-binding property of cullin-2.
Biochemical and biophysical research communications 2002;290(1):294-9.
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2001: Wu G; Vuletich J L; Kulmacz R J; Osawa Y; Tsai A L
Peroxidase self-inactivation in prostaglandin H synthase-1 pretreated with cyclooxygenase inhibitors or substituted with mangano protoporphyrin IX.
The Journal of biological chemistry 2001;276(23):19879-88.
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2001: Wang L H; Tsai A L; Hsu P Y
Substrate binding is the rate-limiting step in thromboxane synthase catalysis.
The Journal of biological chemistry 2001;276(18):14737-43.
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2001: Peng S; Okeley N M; Tsai A L; Wu G; Kulmacz R J; van der Donk W A
Structural characterization of a pentadienyl radical intermediate formed during catalysis by prostaglandin H synthase-2.
Journal of the American Chemical Society 2001;123(15):3609-10.
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2000: Hsu P Y; Tsai A L; Wang L H
Identification of thromboxane synthase amino acid residues involved in heme-propionate binding.
Archives of biochemistry and biophysics 2000;383(1):119-27.
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2000: Lou B S; Snyder J K; Marshall P; Wang J S; Wu G; Kulmacz R J; Tsai A L; Wang J
Resonance Raman studies indicate a unique heme active site in prostaglandin H synthase.
Biochemistry 2000;39(40):12424-34.
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2000: Berka V; Tsai A L
Characterization of interactions among the heme center, tetrahydrobiopterin, and L-arginine binding sites of ferric eNOS using imidazole, cyanide, and nitric oxide as probes.
Biochemistry 2000;39(31):9373-83.
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1999: Négrerie M; Berka V; Vos M H; Liebl U; Lambry J C; Tsai A L; Martin J L
Geminate recombination of nitric oxide to endothelial nitric-oxide synthase and mechanistic implications.
The Journal of biological chemistry 1999;274(35):24694-702.
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1999: Lu G; Tsai A L; Van Wart H E; Kulmacz R J
Comparison of the peroxidase reaction kinetics of prostaglandin H synthase-1 and -2.
The Journal of biological chemistry 1999;274(23):16162-7.
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1999: Wu G; Wei C; Kulmacz R J; Osawa Y; Tsai A L
A mechanistic study of self-inactivation of the peroxidase activity in prostaglandin H synthase-1.
The Journal of biological chemistry 1999;274(14):9231-7.
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1999: Hsu P Y; Tsai A L; Kulmacz R J; Wang L H
Expression, purification, and spectroscopic characterization of human thromboxane synthase.
The Journal of biological chemistry 1999;274(2):762-9.
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1998: Ledvina P S; Tsai A L; Wang Z; Koehl E; Quiocho F A
Dominant role of local dipolar interactions in phosphate binding to a receptor cleft with an electronegative charge surface: equilibrium, kinetic, and crystallographic studies.
Protein science : a publication of the Protein Society 1998;7(12):2550-9.
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1998: Chen P F; Berka V; Tsai A L; Wu K K
Effects of Asp-369 and Arg-372 mutations on heme environment and function in human endothelial nitric-oxide synthase.
The Journal of biological chemistry 1998;273(51):34164-70.
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1998: Tsai A L; Berka V; Kulmacz R J; Wu G; Palmer G
An improved sample packing device for rapid freeze-trap electron paramagnetic resonance spectroscopy kinetic measurements.
Analytical biochemistry 1998;264(2):165-71.
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1998: Xia Y; Tsai A L; Berka V; Zweier J L
Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process.
The Journal of biological chemistry 1998;273(40):25804-8.
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1998: Waxham M N; Tsai A L; Putkey J A
A mechanism for calmodulin (CaM) trapping by CaM-kinase II defined by a family of CaM-binding peptides.
The Journal of biological chemistry 1998;273(28):17579-84.
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1998: Berka V; Palmer G; Chen P F; Tsai A L
Effects of various imidazole ligands on heme conformation in endothelial nitric oxide synthase.
Biochemistry 1998;37(17):6136-44.
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1997: Tsai A L; Wu G; Kulmacz R J
Stoichiometry of the interaction of prostaglandin H synthase with substrates.
Biochemistry 1997;36(42):13085-94.
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1997: Chen P F; Tsai A L; Berka V; Wu K K
Mutation of Glu-361 in human endothelial nitric-oxide synthase selectively abolishes L-arginine binding without perturbing the behavior of heme and other redox centers.
The Journal of biological chemistry 1997;272(10):6114-8.
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1997: Xiao G; Tsai A L; Palmer G; Boyar W C; Marshall P J; Kulmacz R J
Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.
Biochemistry 1997;36(7):1836-45.
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1996: Berka V; Chen P F; Tsai A L
Spatial relationship between L-arginine and heme binding sites of endothelial nitric-oxide synthase.
The Journal of biological chemistry 1996;271(52):33293-300.
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1996: Tsai A L; Berka V; Chen P F; Palmer G
Characterization of endothelial nitric-oxide synthase and its reaction with ligand by electron paramagnetic resonance spectroscopy.
The Journal of biological chemistry 1996;271(51):32563-71.
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1996: Chen P F; Tsai A L; Berka V; Wu K K
Endothelial nitric-oxide synthase. Evidence for bidomain structure and successful reconstitution of catalytic activity from two separate domains generated by a baculovirus expression system.
The Journal of biological chemistry 1996;271(24):14631-5.
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1995: Chen P F; Tsai A L; Wu K K
Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity.
Biochemical and biophysical research communications 1995;215(3):1119-29.
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1995: Wei C; Kulmacz R J; Tsai A L
Comparison of branched-chain and tightly coupled reaction mechanisms for prostaglandin H synthase.
Biochemistry 1995;34(26):8499-512.
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1994: Sanduja S K; Tsai A L; Matijevic-Aleksic N; Wu K K
Kinetics of prostacyclin synthesis in PGHS-1-overexpressed endothelial cells.
The American journal of physiology 1994;267(5 Pt 1):C1459-66.
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1994: Chen P F; Tsai A L; Wu K K
Cysteine 184 of endothelial nitric oxide synthase is involved in heme coordination and catalytic activity.
The Journal of biological chemistry 1994;269(40):25062-6.
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1994: Tsai A L; Wei C; Kulmacz R J
Interaction between nitric oxide and prostaglandin H synthase.
Archives of biochemistry and biophysics 1994;313(2):367-72.
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1994: Kulmacz R J; Palmer G; Wei C; Tsai A L
Reaction and free radical kinetics of prostaglandin H synthase with manganese protoporphyrin IX as the prosthetic group.
Biochemistry 1994;33(18):5428-39.
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1993: Tsai A L; Kulmacz R J; Wang J S; Wang Y; Van Wart H E; Palmer G
Heme coordination of prostaglandin H synthase.
The Journal of biological chemistry 1993;268(12):8554-63.
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1993: Kulmacz R J; Palmer G; Tsai A L
Substrate-induced free radicals in prostaglandin H synthase.
Journal of lipid mediators 1993;6(1-3):145-54.
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1993: Hsi L C; Tsai A L; Kulmacz R J; English D G; Siefker A O; Otto J C; Smith W L
Trp387 and the putative leucine zippers of PGH synthases-1 and -2.
Journal of lipid mediators 1993;6(1-3):131-8.
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1992: Tsai A L; Palmer G; Kulmacz R J
Prostaglandin H synthase. Kinetics of tyrosyl radical formation and of cyclooxygenase catalysis.
The Journal of biological chemistry 1992;267(25):17753-9.
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1992: Zhang X; Tsai A L; Kulmacz R J
Chemical modification of prostaglandin H synthase with diethyl pyrocarbonate.
Biochemistry 1992;31(9):2528-38.
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1991: Tsai A L; Hsu M J; Patsch W; Wu K K
Regulation of PGI2 activity by serum proteins: serum albumin but not high density lipoprotein is the PGI2 binding and stabilizing protein in human blood.
Biochimica et biophysica acta 1991;1115(2):131-40.
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1991: Kulmacz R J; Palmer G; Tsai A L
Prostaglandin H synthase: perturbation of the tyrosyl radical as a probe of anticyclooxygenase agents.
Molecular pharmacology 1991;40(5):833-7.
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1991: Tsai A L; Strobel-Jager E; Wu K K
Conformation of receptor-associated PGI2: an investigation by molecular modeling.
Journal of computer-aided molecular design 1991;5(2):135-48.
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1991: Wu K K; Sanduja R; Tsai A L; Ferhanoglu B; Loose-Mitchell D S
Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2384-7.
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1991: Kulmacz R J; Ren Y; Tsai A L; Palmer G
PGH synthase:interaction with hydroperoxides and indomethacin.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():137-40.
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1991: Tsai A L; Sanduja R; Wu K K
Evidence for two pools of prostaglandin H synthase in human endothelial cells.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():141-4.
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1990: Kulmacz R J; Ren Y; Tsai A L; Palmer G
Prostaglandin H synthase: spectroscopic studies of the interaction with hydroperoxides and with indomethacin.
Biochemistry 1990;29(37):8760-71.
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1989: Tsai A L; Hsu M J; Wu K K
Characterization of the interaction between prostacyclin and human serum albumin using a fluorescent analogue, 2,6-dichloro-4-aminophenol iloprost.
Biochimica et biophysica acta 1989;993(1):74-82.
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1989: Tsai A L; Hsu M J; Vijjeswarapu H; Wu K K
Solubilization of prostacyclin membrane receptors from human platelets.
The Journal of biological chemistry 1989;264(1):61-7.
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1989: Tsai A L; Wu K K
Structure-activity relationship between prostacyclin and its platelet receptor. Correlation of structure change and the platelet activity.
Eicosanoids 1989;2(3):131-43.
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1988: Tsai A L; Manner C E; Rudersdorf T; Wu K K
Quantitation of serum prostacyclin-binding in thrombotic thrombocytopenic purpura.
Thrombosis research 1988;51(6):583-92.
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1988: Tsai A L; Vijjeswarapu H; Wu K K
Interaction between platelet receptor and iloprost isomers.
Biochimica et biophysica acta 1988;942(2):220-6.
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1987: Kulmacz R J; Tsai A L; Palmer G
Heme spin states and peroxide-induced radical species in prostaglandin H synthase.
The Journal of biological chemistry 1987;262(22):10524-31.
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