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Han-Mou Tsai

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Tsai H-M
The kidney in thrombotic thrombocytopenic purpura.
Tsai Han-Mou
Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency.
Zhou Wenhua; Bouhassira Eric E; Tsai Han-Mou
An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.

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All Publications

2007: Tsai H-M
The kidney in thrombotic thrombocytopenic purpura.
Minerva medica 2007;98(6):731-47.
2007: Tsai Han-Mou
Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency.
Hematology/oncology clinics of North America 2007;21(4):609-32, v.
2007: Zhou Wenhua; Bouhassira Eric E; Tsai Han-Mou
An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.
Blood 2007;110(3):886-93.
2007: Manea Minola; Kristoffersson AnnCharlotte; Tsai Han-Mou; Zhou Wenhua; Winqvist Ingemar; Oldaeus Göran; Billström Rolf; Björk Peter; Holmberg Lars; Karpman Diana
ADAMTS13 phenotype in plasma from normal individuals and patients with thrombotic thrombocytopenic purpura.
European journal of pediatrics 2007;166(3):249-57.
2006: Tsai Han-Mou
ADAMTS13 and microvascular thrombosis.
Expert review of cardiovascular therapy 2006;4(6):813-25.
2006: Tsai H-M
The molecular biology of thrombotic microangiopathy.
Kidney international 2006;70(1):16-23.
2006: Tsai Han-Mou; Raoufi Mojgan; Zhou Wenhua; Guinto Enriqueta; Grafos Nickolas; Ranzurmal Safi; Greenfield Robert S; Rand Jacob H
ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura.
Thrombosis and haemostasis 2006;95(5):886-92.
2006: Tsai Han-Mou
Current concepts in thrombotic thrombocytopenic purpura.
Annual review of medicine 2006;57():419-36.
2005: Zhou Wenhua; Dong Lingli; Ginsburg David; Bouhassira Eric E; Tsai Han-Mou
Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?
The Journal of biological chemistry 2005;280(48):39934-41.
2005: Motto David G; Chauhan Anil K; Zhu Guojing; Homeister Jonathon; Lamb Colin B; Desch Karl C; Zhang Weirui; Tsai Han-Mou; Wagner Denisa D; Ginsburg David
Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice.
The Journal of clinical investigation 2005;115(10):2752-61.
2005: Zhou Wenhua; Inada Mari; Lee Tai-Ping; Benten Daniel; Lyubsky Sergey; Bouhassira Eric E; Gupta Sanjeev; Tsai Han-Mou
ADAMTS13 is expressed in hepatic stellate cells.
Laboratory investigation; a journal of technical methods and pathology 2005;85(6):780-8.
2004: Tsai Han-Mou
Molecular mechanisms in thrombotic thrombocytopenic purpura.
Seminars in thrombosis and hemostasis 2004;30(5):549-57.
2004: Tsai H-M
A journey from sickle cell anemia to ADAMTS13.
Journal of thrombosis and haemostasis : JTH 2004;2(9):1510-4.
2004: Schiff Deborah E; Roberts William D; Willert Jennifer; Tsai Han-Mou
Thrombocytopenia and severe hyperbilirubinemia in the neonatal period secondary to congenital thrombotic thrombocytopenic purpura and ADAMTS13 deficiency.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2004;26(8):535-8.
2004: Zhou Wenhua; Tsai Han-Mou
An enzyme immunoassay of ADAMTS13 distinguishes patients with thrombotic thrombocytopenic purpura from normal individuals and carriers of ADAMTS13 mutations.
Thrombosis and haemostasis 2004;91(4):806-11.
2004: Yomtovian Roslyn; Niklinski Waldemar; Silver Bernard; Sarode Ravindra; Tsai Han-Mou
Rituximab for chronic recurring thrombotic thrombocytopenic purpura: a case report and review of the literature.
British journal of haematology 2004;124(6):787-95.
2004: Downes Katharine A; Yomtovian Roslyn; Tsai H M; Silver Bernard; Rutherford Cynthia; Sarode Ravindra
Relapsed thrombotic thrombocytopenic purpura presenting as an acute cerebrovascular accident.
Journal of clinical apheresis 2004;19(2):86-9.
2003: Tsai Han-Mou
Shear stress and von Willebrand factor in health and disease.
Seminars in thrombosis and hemostasis 2003;29(5):479-88.
2003: Tsai H-M
Deficiency of ADAMTS-13 in thrombotic and thrombocytopenic purpura.
Journal of thrombosis and haemostasis : JTH 2003;1(9):2038-40; discussion 2040-5.
2003: Savasan Sureyya; Lee Soon-Ki; Ginsburg David; Tsai Han-Mou
ADAMTS13 gene mutation in congenital thrombotic thrombocytopenic purpura with previously reported normal VWF cleaving protease activity.
Blood 2003;101(11):4449-51.
2003: Tsai H-M
Is severe deficiency of ADAMTS-13 specific for thrombotic thrombocytopenic purpura? Yes.
Journal of thrombosis and haemostasis : JTH 2003;1(4):625-31.
2003: Tsai Han-Mou
Advances in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura.
Journal of the American Society of Nephrology : JASN 2003;14(4):1072-81.
2003: Tsai Han-Mou
Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(3):388-96.
2003: Tsai Han-Mou; Shulman Keith
Rituximab induces remission of cerebral ischemia caused by thrombotic thrombocytopenic purpura.
European journal of haematology 2003;70(3):183-5.
2003: Jubinsky Paul T; Moraille Richard; Tsai Han-Mou
Thrombotic thrombocytopenic purpura in a newborn.
Journal of perinatology : official journal of the California Perinatal Association 2003;23(1):85-7.
2003: Forman Robin B; Benkel Seth A; Novik Yelena; Tsai Han-Mou
Presence of ADAMTS13 activity in a patient with metastatic cancer and thrombotic microangiopathy.
Acta haematologica 2003;109(3):150-2.
2002: Tarr Phillip I; Tsai Han-Mou; Chandler Wayne L
Thrombotic microangiopathies.
The New England journal of medicine 2002;347(26):2171-3; author reply 2171-3.
2002: Tsai Han-Mou; Sarode Ravindra; Downes Katharine A
Ultralarge von Willebrand factor multimers and normal ADAMTS13 activity in the umbilical cord blood.
Thrombosis research 2002;108(2-3):121-5.
2002: Tsai Han-Mou
Deficiency of ADAMTS13 and thrombotic thrombocytopenic purpura.
Transfusion 2002;42(11):1523-4; author reply 1524-5.
2002: Tsai Han-Mou
Deficiency of ADAMTS13 and thrombotic thrombocytopenic purpura.
Blood 2002;100(10):3839-40; author reply 3840-2.
2002: Pham Phuong-Thu T; Danovitch Gabriel M; Wilkinson Alan H; Gritsch H Albin; Pham Phuong-Chi T; Eric Tong M; Kendrick Elizabeth; Charles Lassman R; Tsai Han-Mou
Inhibitors of ADAMTS13: a potential factor in the cause of thrombotic microangiopathy in a renal allograft recipient.
Transplantation 2002;74(8):1077-80.
2002: Tsai Han-Mou
Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura.
Journal of molecular medicine (Berlin, Germany) 2002;80(10):639-47.
2002: Tsai Han-Mou
Deficiency of ADAMTS13 in thrombotic thrombocytopenic purpura.
International journal of hematology 2002;76 Suppl 2():132-8.
2002: Raff Joshua P; Dobson Cassandra E; Tsai Han-Mou
Transfusion of polymerised human haemoglobin in a patient with severe sickle-cell anaemia.
Lancet 2002;360(9331):464-5.
2002: Gutterman Lorence A; Kloster Bruce; Tsai Han-Mou
Rituximab therapy for refractory thrombotic thrombocytopenic purpura.
Blood cells, molecules & diseases 2002;28(3):385-91.
2002: Cosmai Elizabeth M; Puzis Leopold; Tsai H-M; Lian Eric C-Y
Thrombocytopenic purpura and cardiomyopathy in pregnancy reversed by combined plasma exchange and infusion.
European journal of haematology 2002;68(4):239-42.
2002: Tsai Han-Mou; Tarr Phillip I
Rebuttal to: von Willebrand factor-cleaving protease in childhood diarrhoea-associated haemolytic uraemic syndrome.
Thrombosis and haemostasis 2002;87(3):548-9; author's reply 549-50.
2002: Robson William Lane M; Tsai Han-Mou
Thrombotic thrombocytopenic purpura attributable to von Willebrand factor-cleaving protease inhibitor in an 8-year-old boy.
Pediatrics 2002;109(2):322-5.
2002: Morgensztern Daniel; Kharfan-Dabaja Mohamed A; Tsai Han-Mou; Lian Eric C-Y
Warm-antibody autoimmune hemolytic anemia developing after thrombotic thrombocytopenic purpura.
Acta haematologica 2002;108(3):154-6.
2001: Levy G G; Nichols W C; Lian E C; Foroud T; McClintick J N; McGee B M; Yang A Y; Siemieniak D R; Stark K R; Gruppo R; Sarode R; Shurin S B; Chandrasekaran V; Stabler S P; Sabio H; Bouhassira E E; Upshaw J D; Ginsburg D; Tsai H M
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.
Nature 2001;413(6855):488-94.
2001: Tsai H M; Chandler W L; Sarode R; Hoffman R; Jelacic S; Habeeb R L; Watkins S L; Wong C S; Williams G D; Tarr P I
von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome.
Pediatric research 2001;49(5):653-9.
2001: Tsai H M; Li A; Rock G
Inhibitors of von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura.
Clinical laboratory 2001;47(7-8):387-92.
2000: Tsai H M
High titers of inhibitors of von Willebrand factor-cleaving metalloproteinase in a fatal case of acute thrombotic thrombocytopenic purpura.
American journal of hematology 2000;65(3):251-5.
2000: Sarode R; Goldstein J; Sussman I I; Nagel R L; Tsai H M
Role of A and B blood group antigens in the expression of adhesive activity of von Willebrand factor.
British journal of haematology 2000;109(4):857-64.
2000: Kaul D K; Tsai H M; Liu X D; Nakada M T; Nagel R L; Coller B S
Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor.
Blood 2000;95(2):368-74.
1998: Tsai H M; Lian E C
Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura.
The New England journal of medicine 1998;339(22):1585-94.
1997: Lankhof H; Damas C; Schiphorst M E; Ijsseldijk M J; Bracke M; Furlan M; Tsai H M; de Groot P G; Sixma J J; Vink T
von Willebrand factor without the A2 domain is resistant to proteolysis.
Thrombosis and haemostasis 1997;77(5):1008-13.
1997: Tsai H M; Sussman I I; Ginsburg D; Lankhof H; Sixma J J; Nagel R L
Proteolytic cleavage of recombinant type 2A von Willebrand factor mutants R834W and R834Q: inhibition by doxycycline and by monoclonal antibody VP-1.
Blood 1997;89(6):1954-62.
1996: Tsai H M
Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion.
Blood 1996;87(10):4235-44.
1994: Tsai H M; Sussman I I; Nagel R L
Shear stress enhances the proteolysis of von Willebrand factor in normal plasma.
Blood 1994;83(8):2171-9.
1993: Kaul D K; Nagel R L; Chen D; Tsai H M
Sickle erythrocyte-endothelial interactions in microcirculation: the role of von Willebrand factor and implications for vasoocclusion.
Blood 1993;81(9):2429-38.
1991: Tsai H M; Nagel R L; Hatcher V B; Seaton A C; Sussman I I
The high molecular weight form of endothelial cell von Willebrand factor is released by the regulated pathway.
British journal of haematology 1991;79(2):239-45.
1991: Tsai H M; Nagel R L; Sussman I I
Subunit composition of plasma von Willebrand factor multimers: evidence for a non-proteolytic mechanism resulting in apparent increase in proteolytic fragments.
Thrombosis research 1991;63(1):179-88.
1990: Tsai H M; Sussman I I; Nagel R L; Kaul D K
Desmopressin induces adhesion of normal human erythrocytes to the endothelial surface of a perfused microvascular preparation.
Blood 1990;75(1):261-5.
1989: Tsai H M; Nagel R L; Hatcher V B; Sussman I I
Multimeric composition of endothelial cell-derived von Willebrand factor.
Blood 1989;73(8):2074-6.
1989: Tsai H M; Nagel R L; Hatcher V B; Sussman I I
Endothelial cell-derived high molecular weight von Willebrand factor is converted into the plasma multimer pattern by granulocyte proteases.
Biochemical and biophysical research communications 1989;158(3):980-5.

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