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Han-Mou Tsai

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Han-Mou Tsai
The kidney in thrombotic thrombocytopenic purpura.
Han-Mou Tsai
Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency.
Wenhua Zhou; Eric E Bouhassira; Han-Mou Tsai
An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.

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All Publications

2007: Han-Mou Tsai
The kidney in thrombotic thrombocytopenic purpura.
Minerva medica 2007;98(6):731-47.
2007: Han-Mou Tsai
Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency.
Hematology/oncology clinics of North America 2007;21(4):609-32, v.
2007: Wenhua Zhou; Eric E Bouhassira; Han-Mou Tsai
An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.
Blood 2007;110(3):886-93.
2007: Minola Manea; AnnCharlotte Kristoffersson; Han-Mou Tsai; Wenhua Zhou; Ingemar Winqvist; Göran Oldaeus; Rolf Billström; Peter Björk; Lars Holmberg; Diana Karpman
ADAMTS13 phenotype in plasma from normal individuals and patients with thrombotic thrombocytopenic purpura.
European journal of pediatrics 2007;166(3):249-57.
2006: Han-Mou Tsai
ADAMTS13 and microvascular thrombosis.
Expert review of cardiovascular therapy 2006;4(6):813-25.
2006: Han-Mou Tsai
The molecular biology of thrombotic microangiopathy.
Kidney international 2006;70(1):16-23.
2006: Han-Mou Tsai; Mojgan Raoufi; Wenhua Zhou; Enriqueta Guinto; Nickolas Grafos; Safi Ranzurmal; Robert S Greenfield; Jacob H Rand
ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura.
Thrombosis and haemostasis 2006;95(5):886-92.
2006: Han-Mou Tsai
Current concepts in thrombotic thrombocytopenic purpura.
Annual review of medicine 2006;57():419-36.
2005: Wenhua Zhou; Lingli Dong; David Ginsburg; Eric E Bouhassira; Han-Mou Tsai
Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?
The Journal of biological chemistry 2005;280(48):39934-41.
2005: David G Motto; Anil K Chauhan; Guojing Zhu; Jonathon W Homeister; Colin B Lamb; Karl C Desch; Weirui Zhang; Han-Mou Tsai; Denisa D Wagner; David Ginsburg
Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice.
The Journal of clinical investigation 2005;115(10):2752-61.
2005: Wenhua Zhou; Mari Inada; Tai-Ping Lee; Daniel Benten; Sergey Lyubsky; Eric E Bouhassira; Sanjeev Gupta; Han-Mou Tsai
ADAMTS13 is expressed in hepatic stellate cells.
Laboratory investigation; a journal of technical methods and pathology 2005;85(6):780-8.
2004: Han-Mou Tsai
Molecular mechanisms in thrombotic thrombocytopenic purpura.
Seminars in thrombosis and hemostasis 2004;30(5):549-57.
2004: Han-Mou Tsai
A journey from sickle cell anemia to ADAMTS13.
Journal of thrombosis and haemostasis : JTH 2004;2(9):1510-4.
2004: Deborah E Schiff; William D Roberts; Jennifer Willert; Han-Mou Tsai
Thrombocytopenia and severe hyperbilirubinemia in the neonatal period secondary to congenital thrombotic thrombocytopenic purpura and ADAMTS13 deficiency.
Journal of pediatric hematology/oncology 2004;26(8):535-8.
2004: Wenhua Zhou; Han-Mou Tsai
An enzyme immunoassay of ADAMTS13 distinguishes patients with thrombotic thrombocytopenic purpura from normal individuals and carriers of ADAMTS13 mutations.
Thrombosis and haemostasis 2004;91(4):806-11.
2004: Roslyn Yomtovian; Waldemar Niklinski; Bernard Silver; Ravindra Sarode; Han-Mou Tsai
Rituximab for chronic recurring thrombotic thrombocytopenic purpura: a case report and review of the literature.
British journal of haematology 2004;124(6):787-95.
2004: Katharine A Downes; Roslyn Yomtovian; Han-Mou Tsai; Bernard Silver; Cynthia Rutherford; Ravindra Sarode
Relapsed thrombotic thrombocytopenic purpura presenting as an acute cerebrovascular accident.
Journal of clinical apheresis 2004;19(2):86-9.
2003: Han-Mou Tsai
Shear stress and von Willebrand factor in health and disease.
Seminars in thrombosis and hemostasis 2003;29(5):479-88.
2003: Han-Mou Tsai
Deficiency of ADAMTS-13 in thrombotic and thrombocytopenic purpura.
Journal of thrombosis and haemostasis : JTH 2003;1(9):2038-40; discussion 2040-5.
2003: Süreyya Savasan; Soon-Ki Lee; David Ginsburg; Han-Mou Tsai
ADAMTS13 gene mutation in congenital thrombotic thrombocytopenic purpura with previously reported normal VWF cleaving protease activity.
Blood 2003;101(11):4449-51.
2003: Han-Mou Tsai
Is severe deficiency of ADAMTS-13 specific for thrombotic thrombocytopenic purpura? Yes.
Journal of thrombosis and haemostasis : JTH 2003;1(4):625-31.
2003: Han-Mou Tsai
Advances in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura.
Journal of the American Society of Nephrology : JASN 2003;14(4):1072-81.
2003: Han-Mou Tsai
Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(3):388-96.
2003: Han-Mou Tsai; Keith Shulman
Rituximab induces remission of cerebral ischemia caused by thrombotic thrombocytopenic purpura.
European journal of haematology 2003;70(3):183-5.
2003: Robin B Forman; Seth A Benkel; Yelena Novik; Han-Mou Tsai
Presence of ADAMTS13 activity in a patient with metastatic cancer and thrombotic microangiopathy.
Acta haematologica 2003;109(3):150-2.
2003: Paul T Jubinsky; Richard Moraille; Han-Mou Tsai
Thrombotic thrombocytopenic purpura in a newborn.
Journal of perinatology : official journal of the California Perinatal Association 2003;23(1):85-7.
2002: Phillip I Tarr; Han-Mou Tsai; Wayne L Chandler
Thrombotic microangiopathies.
The New England journal of medicine 2002;347(26):2171-3; author reply 2171-3.
2002: Han-Mou Tsai
Deficiency of ADAMTS13 and thrombotic thrombocytopenic purpura.
Blood 2002;100(10):3839-40; author reply 3840-2.
2002: Han-Mou Tsai; Ravindra Sarode; Katharine A Downes
Ultralarge von Willebrand factor multimers and normal ADAMTS13 activity in the umbilical cord blood.
Thrombosis research 2002;108(2-3):121-5.
2002: Han-Mou Tsai
Deficiency of ADAMTS13 and thrombotic thrombocytopenic purpura.
Transfusion 2002;42(11):1523-4; author reply 1524-5.
2002: Phuong-Thu T Pham; Gabriel M Danovitch; Alan H Wilkinson; H Albin Gritsch; Phuong-Chi T Pham; Tong M Eric; Elizabeth Kendrick; Lassman R Charles; Han-Mou Tsai
Inhibitors of ADAMTS13: a potential factor in the cause of thrombotic microangiopathy in a renal allograft recipient.
Transplantation 2002;74(8):1077-80.
2002: Han-Mou Tsai
Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura.
Journal of molecular medicine (Berlin, Germany) 2002;80(10):639-47.
2002: Joshua P Raff; Cassandra E Dobson; Han-Mou Tsai
Transfusion of polymerised human haemoglobin in a patient with severe sickle-cell anaemia.
Lancet 2002;360(9331):464-5.
2002: Han-Mou Tsai
Deficiency of ADAMTS13 in thrombotic thrombocytopenic purpura.
International journal of hematology 2002;76 Suppl 2():132-8.
2002: Lorence A Gutterman; Bruce Kloster; Han-Mou Tsai
Rituximab therapy for refractory thrombotic thrombocytopenic purpura.
Blood cells, molecules & diseases 2002;28(3):385-91.
2002: Elizabeth M Cosmai; Leopold Puzis; Han-Mou Tsai; Eric C-Y Lian
Thrombocytopenic purpura and cardiomyopathy in pregnancy reversed by combined plasma exchange and infusion.
European journal of haematology 2002;68(4):239-42.
2002: Han-Mou Tsai; Phillip I Tarr
Rebuttal to: von Willebrand factor-cleaving protease in childhood diarrhoea-associated haemolytic uraemic syndrome.
Thrombosis and haemostasis 2002;87(3):548-9; author's reply 549-50.
2002: William Lane M Robson; Han-Mou Tsai
Thrombotic thrombocytopenic purpura attributable to von Willebrand factor-cleaving protease inhibitor in an 8-year-old boy.
Pediatrics 2002;109(2):322-5.
2002: Daniel Morgensztern; Mohamed A Kharfan-Dabaja; Han-Mou Tsai; Eric C-Y Lian
Warm-antibody autoimmune hemolytic anemia developing after thrombotic thrombocytopenic purpura.
Acta haematologica 2002;108(3):154-6.
2001: Gallia G Levy; William C Nichols; Eric C-Y Lian; Tatiana Foroud; Jeanette McClintick; Beth McGee; Angela Y Yang; DR Siemieniak; K R Stark; R Gruppo; R Sarode; susan shurin; V Chandrasekaran; S P Stabler; H Sabio; Eric E Bouhassira; J D Upshaw; David Ginsburg; Han-Mou Tsai
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.
Nature 2001;413(6855):488-94.
2001: Han-Mou Tsai; Wayne L Chandler; Ravindra Sarode; Robert J Hoffman; Sandra Jelacic; RL Habeeb; Sandra L Watkins; C S Wong; Glyn D Williams; Phillip I Tarr
von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome.
Pediatric research 2001;49(5):653-9.
2001: Han-Mou Tsai; A Li; G Rock
Inhibitors of von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura.
Clinical laboratory 2001;47(7-8):387-92.
2000: Han-Mou Tsai
High titers of inhibitors of von Willebrand factor-cleaving metalloproteinase in a fatal case of acute thrombotic thrombocytopenic purpura.
American journal of hematology 2000;65(3):251-5.
2000: Ravindra Sarode; J Goldstein; Ira I Sussman; Ronald L Nagel; Han-Mou Tsai
Role of A and B blood group antigens in the expression of adhesive activity of von Willebrand factor.
British journal of haematology 2000;109(4):857-64.
2000: Dhananjay K Kaul; Han-Mou Tsai; Xiao-du Liu; Marian T Nakada; Ronald L Nagel; Barry S Coller
Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor.
Blood 2000;95(2):368-74.
1998: Han-Mou Tsai; Eric C-Y Lian
Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura.
The New England journal of medicine 1998;339(22):1585-94.
1997: H Lankhof; C Damas; Marion E Schiphorst; Martin J W IJsseldijk; Madelon Bracke; M Furlan; Han-Mou Tsai; Philip G de Groot; Jan J Sixma; Tom Vink
von Willebrand factor without the A2 domain is resistant to proteolysis.
Thrombosis and haemostasis 1997;77(5):1008-13.
1997: Han-Mou Tsai; Ira I Sussman; David Ginsburg; H Lankhof; Jan J Sixma; Ronald L Nagel
Proteolytic cleavage of recombinant type 2A von Willebrand factor mutants R834W and R834Q: inhibition by doxycycline and by monoclonal antibody VP-1.
Blood 1997;89(6):1954-62.
1996: Han-Mou Tsai
Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion.
Blood 1996;87(10):4235-44.
1994: Han-Mou Tsai; Ira I Sussman; Ronald L Nagel
Shear stress enhances the proteolysis of von Willebrand factor in normal plasma.
Blood 1994;83(8):2171-9.
1993: Dhananjay K Kaul; Ronald L Nagel; D Chen; Han-Mou Tsai
Sickle erythrocyte-endothelial interactions in microcirculation: the role of von Willebrand factor and implications for vasoocclusion.
Blood 1993;81(9):2429-38.
1991: Han-Mou Tsai; Ronald L Nagel; Victor Hatcher; A C Seaton; Ira I Sussman
The high molecular weight form of endothelial cell von Willebrand factor is released by the regulated pathway.
British journal of haematology 1991;79(2):239-45.
1991: Han-Mou Tsai; Ronald L Nagel; Ira I Sussman
Subunit composition of plasma von Willebrand factor multimers: evidence for a non-proteolytic mechanism resulting in apparent increase in proteolytic fragments.
Thrombosis research 1991;63(1):179-88.
1990: Han-Mou Tsai; Ira I Sussman; Ronald L Nagel; Dhananjay K Kaul
Desmopressin induces adhesion of normal human erythrocytes to the endothelial surface of a perfused microvascular preparation.
Blood 1990;75(1):261-5.
1989: Han-Mou Tsai; Ronald L Nagel; Victor Hatcher; Ira I Sussman
Multimeric composition of endothelial cell-derived von Willebrand factor.
Blood 1989;73(8):2074-6.
1989: Han-Mou Tsai; Ronald L Nagel; Victor Hatcher; Ira I Sussman
Endothelial cell-derived high molecular weight von Willebrand factor is converted into the plasma multimer pattern by granulocyte proteases.
Biochemical and biophysical research communications 1989;158(3):980-5.