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Rachel Tsan

Research Profile

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Chemicals & Drugs

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Publications

TOP 3
Chenyu Zhang; Fahao Zhang; Rachel Tsan; Isaiah J Fidler
Transforming growth factor-beta2 is a molecular determinant for site-specific melanoma metastasis in the brain.
Takamitsu Sasaki; Toru Nakamura; robert rebhun; Hua Cheng; Katherine Stemke Hale; Rachel Tsan; Isaiah J Fidler; Robert R Langley
Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.
Weihua Zhang; Rachel Tsan; Huang Wei-Chien; Qiuyu Wu; Chao-Hua Chiu; Isaiah J Fidler; Mien-Chie Hung
Survival of cancer cells is maintained by EGFR independent of its kinase activity.

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All Publications

2009: Chenyu Zhang; Fahao Zhang; Rachel Tsan; Isaiah J Fidler
Transforming growth factor-beta2 is a molecular determinant for site-specific melanoma metastasis in the brain.
Cancer research 2009;69(3):828-35.
2008: Takamitsu Sasaki; Toru Nakamura; robert rebhun; Hua Cheng; Katherine Stemke Hale; Rachel Tsan; Isaiah J Fidler; Robert R Langley
Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.
The American journal of pathology 2008;173(1):205-16.
2008: Weihua Zhang; Rachel Tsan; Huang Wei-Chien; Qiuyu Wu; Chao-Hua Chiu; Isaiah J Fidler; Mien-Chie Hung
Survival of cancer cells is maintained by EGFR independent of its kinase activity.
Cancer cell 2008;13(5):385-93.
2007: Takamitsu Sasaki; Yasuhiko Kitadai; Toru Nakamura; Jang-Seong Kim; Rachel Tsan; Toshio Kuwai; Robert R Langley; Dominic Fan; Sun-Jin Kim; Isaiah J Fidler
Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice.
Neoplasia (New York, N.Y.) 2007;9(12):1066-77.
2007: Wenjuan Wu; Michael S O'Reilly; Robert R Langley; Rachel Tsan; Cheryl H Baker; Neby Bekele; Xi Ming Tang; Amir Onn; Isaiah J Fidler; Roy S Herbst
Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.
Molecular cancer therapeutics 2007;6(10):2652-63.
2006: Weihua Zhang; Rachel Tsan; Do-Hyun Nam; Weixin Lu; Isaiah J Fidler
Loss of adhesion in the circulation converts amelanotic metastatic melanoma cells to melanotic by inhibition of AKT.
Neoplasia (New York, N.Y.) 2006;8(7):543-50.
2005: Weihua Zhang; Rachel Tsan; Alan J Schroit; Isaiah J Fidler
Apoptotic cells initiate endothelial cell sprouting via electrostatic signaling.
Cancer research 2005;65(24):11529-35.
2005: Hua Cheng; Robert R Langley; Qiuyu Wu; Wenjuan Wu; Jie Feng; Rachel Tsan; Dominic Fan; Isaiah J Fidler
Construction of a novel constitutively active chimeric EGFR to identify new targets for therapy.
Neoplasia (New York, N.Y.) 2005;7(12):1065-72.
2005: Premal H Thaker; Sertac Yazici; Monique B Nilsson; Kenji Yokoi; Rachel Tsan; Junqin He; Sun-Jin Kim; Isaiah J Fidler; Anil K Sood
Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4923-33.
2005: Hua Cheng; Carlo Cenciarelli; Gina M Nelkin; Rachel Tsan; Dominic Fan; Cecilia Cheng-Mayer; Isaiah J Fidler
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth.
Molecular and cellular biology 2005;25(1):44-59.
2004: Sun Jin Kim; Hisanori Uehara; Sertac Yazici; Robert R Langley; Junqin He; Rachel Tsan; Dominic Fan; Jerald J Killion; Isaiah J Fidler
Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice.
Cancer research 2004;64(12):4201-8.
2004: Robert R Langley; Dominic Fan; Rachel Tsan; robert rebhun; Junqin He; Sun-Jin Kim; Isaiah J Fidler
Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells.
Cancer research 2004;64(11):3727-30.
2004: E Gregory MacEwen; Josep Pastor; Jonathan Kutzke; Rachel Tsan; Ilene D Kurzman; Douglas Thamm; Mike Wilson; Robert Radinsky
IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma.
Journal of cellular biochemistry 2004;92(1):77-91.
2004: Christopher L Hall; Rachel Tsan; Gabriele Mugnai; Andrew P Mazar; Robert Radinsky; Curtis A Pettaway
Enhanced invasion of hormone refractory prostate cancer cells through hepatocyte growth factor (HGF) induction of urokinase-type plasminogen activator (u-PA).
The Prostate 2004;59(2):167-76.
2003: Rosa F Hwang; Kenji Yokoi; Corazon D Bucana; Rachel Tsan; Jerald J Killion; Douglas B Evans; Isaiah J Fidler
Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6534-44.
2003: Robert R Langley; Karen M Ramirez; Rachel Tsan; Melissa Van Arsdall; Monique B Nilsson; Isaiah J Fidler
Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis.
Cancer research 2003;63(11):2971-6.
2003: Hisanori Uehara; Sun Jin Kim; Takashi Karashima; David L Shepherd; Dominic Fan; Rachel Tsan; Jerald J Killion; Christopher Logothetis; Paul Mathew; Isaiah J Fidler
Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases.
Journal of the National Cancer Institute 2003;95(6):458-70.
2003: E Gregory MacEwen; Jon Kutzke; Jennifer Carew; Josep Pastor; Julie A Schmidt; Rachel Tsan; Douglas Thamm; Robert Radinsky
c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells.
Clinical & experimental metastasis 2003;20(5):421-30.
2003: Matthew H Herynk; Rachel Tsan; Robert Radinsky; Gary E Gallick
Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin.
Clinical & experimental metastasis 2003;20(4):291-300.
2002: Cheryl H Baker; Daniel Kedar; Marya F McCarty; Rachel Tsan; Kristin L Weber; Corazon D Bucana; Isaiah J Fidler
Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas.
The American journal of pathology 2002;161(3):929-38.
2001: Carmen C Solorzano; Cheryl H Baker; Rachel Tsan; Peter Traxler; Pinchas Cohen; Elisabeth Buchdunger; Jerald J Killion; Isaiah J Fidler
Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2563-72.
2000: Christiane J Bruns; Carmen C Solorzano; Matthew T Harbison; S Ozawa; Rachel Tsan; Dominic Fan; James L Abbruzzese; Peter Traxler; Elisabeth Buchdunger; Robert Radinsky; Isaiah J Fidler
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.
Cancer research 2000;60(11):2926-35.
2000: Christiane J Bruns; Matthew T Harbison; Darren W Davis; Charles Portera; Rachel Tsan; David J McConkey; Douglas B Evans; James L Abbruzzese; Daniel J Hicklin; Robert Radinsky
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1936-48.
2000: Charles Portera; H Shinohara; T Mima; A Miller; Rachel Tsan; D Mascarenhas; Robert Radinsky
Targeting the insulin-like growth factor axis in the therapy of colorectal carcinoma liver metastasis.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2000;10 Suppl A():S47-8.
1998: C Parker; BJ Roseman; Corazon D Bucana; Rachel Tsan; Robert Radinsky
Preferential activation of the epidermal growth factor receptor in human colon carcinoma liver metastases in nude mice.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(5):595-602.
1998: Derrick J Beech; R E Pollock; Rachel Tsan; Robert Radinsky
Epidermal growth factor receptor and insulin-like growth factor-I receptor expression and function in human soft-tissue sarcoma cells.
International journal of oncology 1998;12(2):329-36.
1997: R K Singh; Rachel Tsan; Robert Radinsky
Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis.
Clinical & experimental metastasis 1997;15(2):140-50.
1997: Qingyi Wei; Y Guan; Lie Cheng; Robert Radinsky; Menashe Bar-Eli; Rachel Tsan; Li Li; Randy J Legerski
Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction.
Pathobiology : journal of immunopathology, molecular and cellular biology 1997;65(6):293-300.
1995: Robert Radinsky; P J Beltran; Rachel Tsan; R Zhang; R D Cone; Isaiah J Fidler
Transcriptional induction of the melanocyte-stimulating hormone receptor in brain metastases of murine K-1735 melanoma.
Cancer research 1995;55(1):141-8.
1994: K Gohji; Isaiah J Fidler; Rachel Tsan; Robert Radinsky; Andrew C von Eschenbach; T Tsuruo; M Nakajima
Human recombinant interferons-beta and -gamma decrease gelatinase production and invasion by human KG-2 renal-carcinoma cells.
International journal of cancer. Journal international du cancer 1994;58(3):380-4.
1994: Robert Radinsky; Isaiah J Fidler; Janet E Price; Noriko Esumi; Rachel Tsan; C M Petty; Corazon D Bucana; Menashe Bar-Eli
Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53.
Oncogene 1994;9(7):1877-83.
1994: Zhongyun Dong; Robert Radinsky; Dominic Fan; Rachel Tsan; Corazon D Bucana; C Wilmanns; Isaiah J Fidler
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells.
Journal of the National Cancer Institute 1994;86(12):913-20.

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