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David Botstein

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Saccharomyces cerevisiae

Devices

Oligonucleotide Array Sequence Analysis

Genes & Molecular Sequences

Concepts & Ideas

Chemicals & Drugs

Physiology

Procedures

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Publications

TOP 3
Ho Cheuk Hei; Magtanong Leslie; Barker Sarah L; Gresham David; Nishimura Shinichi; Natarajan Paramasivam; Koh Judice L Y; Porter Justin; Gray Christopher A; Andersen Raymond J; Giaever Guri; Nislow Corey; Andrews Brenda; Botstein David; Graham Todd R; Yoshida Minoru; Boone Charles
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.
Lang Gregory I; Murray Andrew W; Botstein David
The cost of gene expression underlies a fitness trade-off in yeast.
Lu Charles; Brauer Matthew J; Botstein David
Slow growth induces heat-shock resistance in normal and respiratory-deficient yeast.

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All Publications

2009: Ho Cheuk Hei; Magtanong Leslie; Barker Sarah L; Gresham David; Nishimura Shinichi; Natarajan Paramasivam; Koh Judice L Y; Porter Justin; Gray Christopher A; Andersen Raymond J; Giaever Guri; Nislow Corey; Andrews Brenda; Botstein David; Graham Todd R; Yoshida Minoru; Boone Charles
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.
Nature biotechnology 2009;27(4):369-77.
2009: Lang Gregory I; Murray Andrew W; Botstein David
The cost of gene expression underlies a fitness trade-off in yeast.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5755-60.
2009: Lu Charles; Brauer Matthew J; Botstein David
Slow growth induces heat-shock resistance in normal and respiratory-deficient yeast.
Molecular biology of the cell 2009;20(3):891-903.
2009: Airoldi Edoardo M; Huttenhower Curtis; Gresham David; Lu Charles; Caudy Amy A; Dunham Maitreya J; Broach James R; Botstein David; Troyanskaya Olga G
Predicting cellular growth from gene expression signatures.
PLoS computational biology 2009;5(1):e1000257.
2008: Boer Viktor M; Amini Sasan; Botstein David
Influence of genotype and nutrition on survival and metabolism of starving yeast.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):6930-5.
2008: Gresham David; Dunham Maitreya J; Botstein David
Comparing whole genomes using DNA microarrays.
Nature reviews. Genetics 2008;9(4):291-302.
2008: Hong Eurie L; Balakrishnan Rama; Dong Qing; Christie Karen R; Park Julie; Binkley Gail; Costanzo Maria C; Dwight Selina S; Engel Stacia R; Fisk Dianna G; Hirschman Jodi E; Hitz Benjamin C; Krieger Cynthia J; Livstone Michael S; Miyasato Stuart R; Nash Robert S; Oughtred Rose; Skrzypek Marek S; Weng Shuai; Wong Edith D; Zhu Kathy K; Dolinski Kara; Botstein David; Cherry J Michael
Gene Ontology annotations at SGD: new data sources and annotation methods.
Nucleic acids research 2008;36(Database issue):D577-81.
2008: Brauer Matthew J; Huttenhower Curtis; Airoldi Edoardo M; Rosenstein Rachel; Matese John C; Gresham David; Boer Viktor M; Troyanskaya Olga G; Botstein David
Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast.
Molecular biology of the cell 2008;19(1):352-67.
2007: Nash Robert; Weng Shuai; Hitz Ben; Balakrishnan Rama; Christie Karen R; Costanzo Maria C; Dwight Selina S; Engel Stacia R; Fisk Dianna G; Hirschman Jodi E; Hong Eurie L; Livstone Michael S; Oughtred Rose; Park Julie; Skrzypek Marek; Theesfeld Chandra L; Binkley Gail; Dong Qing; Lane Christopher; Miyasato Stuart; Sethuraman Anand; Schroeder Mark; Dolinski Kara; Botstein David; Cherry J Michael
Expanded protein information at SGD: new pages and proteome browser.
Nucleic acids research 2007;35(Database issue):D468-71.
2007: Heinicke Sven; Livstone Michael S; Lu Charles; Oughtred Rose; Kang Fan; Angiuoli Samuel V; White Owen; Botstein David; Dolinski Kara
The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists.
PloS one 2007;2(1):e766.
2007: Dolinski Kara; Botstein David
Orthology and functional conservation in eukaryotes.
Annual review of genetics 2007;41():465-507.
2007: Schacherer Joseph; Ruderfer Douglas M; Gresham David; Dolinski Kara; Botstein David; Kruglyak Leonid
Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains.
PloS one 2007;2(3):e322.
2006: Pelham Robert J; Rodgers Linda; Hall Ira; Lucito Robert; Nguyen Ken C Q; Navin Nicholas; Hicks James; Mu David; Powers Scott; Wigler Michael; Botstein David
Identification of alterations in DNA copy number in host stromal cells during tumor progression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19848-53.
2006: Brauer Matthew J; Yuan Jie; Bennett Bryson D; Lu Wenyun; Kimball Elizabeth; Botstein David; Rabinowitz Joshua D
Conservation of the metabolomic response to starvation across two divergent microbes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19302-7.
2006: Sørlie Therese; Perou Charles M; Fan Cheng; Geisler Stephanie; Aas Turid; Nobel Andrew; Anker Gun; Akslen Lars A; Botstein David; Børresen-Dale Anne-Lise; Lønning Per Eystein
Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer.
Molecular cancer therapeutics 2006;5(11):2914-8.
2006: Wingreen Ned; Botstein David
Back to the future: education for systems-level biologists.
Nature reviews. Molecular cell biology 2006;7(11):829-32.
2006: Hess David C; Lu Wenyun; Rabinowitz Joshua D; Botstein David
Ammonium toxicity and potassium limitation in yeast.
PLoS biology 2006;4(11):e351.
2006: Fisk Dianna G; Ball Catherine A; Dolinski Kara; Engel Stacia R; Hong Eurie L; Issel-Tarver Laurie; Schwartz Katja; Sethuraman Anand; Botstein David; Cherry J Michael;
Saccharomyces cerevisiae S288C genome annotation: a working hypothesis.
Yeast (Chichester, England) 2006;23(12):857-65.
2006: Heck Julie Akiko; Gresham David; Botstein David; Alani Eric
Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements.
Genetics 2006;174(1):519-23.
2006: Botstein David
Willing to do the math: an interview with David Botstein. Interview by Jane Gitschier.
PLoS genetics 2006;2(5):e79.
2006: Gresham David; Ruderfer Douglas M; Pratt Stephen C; Schacherer Joseph; Dunham Maitreya J; Botstein David; Kruglyak Leonid
Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray.
Science (New York, N.Y.) 2006;311(5769):1932-6.
2006: Diehn Maximilian; Bhattacharya Ramona; Botstein David; Brown Patrick O
Genome-scale identification of membrane-associated human mRNAs.
PLoS genetics 2006;2(1):e11.
2006: Hirschman Jodi E; Balakrishnan Rama; Christie Karen R; Costanzo Maria C; Dwight Selina S; Engel Stacia R; Fisk Dianna G; Hong Eurie L; Livstone Michael S; Nash Robert; Park Julie; Oughtred Rose; Skrzypek Marek; Starr Barry; Theesfeld Chandra L; Williams Jennifer; Andrada Rey; Binkley Gail; Dong Qing; Lane Christopher; Miyasato Stuart; Sethuraman Anand; Schroeder Mark; Thanawala Mayank K; Weng Shuai; Dolinski Kara; Botstein David; Cherry J Michael
Genome Snapshot: a new resource at the Saccharomyces Genome Database (SGD) presenting an overview of the Saccharomyces cerevisiae genome.
Nucleic acids research 2006;34(Database issue):D442-5.
2006: Ronen Michal; Botstein David
Transcriptional response of steady-state yeast cultures to transient perturbations in carbon source.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(2):389-94.
2006: Reguly Teresa; Breitkreutz Ashton; Boucher Lorrie; Breitkreutz Bobby-Joe; Hon Gary C; Myers Chad L; Parsons Ainslie; Friesen Helena; Oughtred Rose; Tong Amy; Stark Chris; Ho Yuen; Botstein David; Andrews Brenda; Boone Charles; Troyanskya Olga G; Ideker Trey; Dolinski Kara; Batada Nizar N; Tyers Mike
Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae.
Journal of biology 2006;5(4):11.
2005: Dolinski Kara; Botstein David
Changing perspectives in yeast research nearly a decade after the genome sequence.
Genome research 2005;15(12):1611-9.
2005: Brauer Matthew J; Saldanha Alok J; Dolinski Kara; Botstein David
Homeostatic adjustment and metabolic remodeling in glucose-limited yeast cultures.
Molecular biology of the cell 2005;16(5):2503-17.
2005: Liang Yu; Diehn Maximilian; Watson Nathan; Bollen Andrew W; Aldape Ken D; Nicholas M Kelly; Lamborn Kathleen R; Berger Mitchel S; Botstein David; Brown Patrick O; Israel Mark A
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5814-9.
2005: Wang Wei; Cherry J Michael; Nochomovitz Yigal; Jolly Emmitt; Botstein David; Li Hao
Inference of combinatorial regulation in yeast transcriptional networks: a case study of sporulation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1998-2003.
2005: Balakrishnan Rama; Christie Karen R; Costanzo Maria C; Dolinski Kara; Dwight Selina S; Engel Stacia R; Fisk Dianna G; Hirschman Jodi E; Hong Eurie L; Nash Robert; Oughtred Rose; Skrzypek Marek; Theesfeld Chandra L; Binkley Gail; Dong Qing; Lane Christopher; Sethuraman Anand; Weng Shuai; Botstein David; Cherry J Michael
Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD).
Nucleic acids research 2005;33(Database issue):D374-7.
2005: Shyamsundar Radha; Kim Young H; Higgins John P; Montgomery Kelli; Jorden Michelle; Sethuraman Anand; van de Rijn Matt; Botstein David; Brown Patrick O; Pollack Jonathan R
A DNA microarray survey of gene expression in normal human tissues.
Genome biology 2005;6(3):R22.
2004: Shapira Michael; Segal Eran; Botstein David
Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress.
Molecular biology of the cell 2004;15(12):5659-69.
2004: Boyle Elizabeth I; Weng Shuai; Gollub Jeremy; Jin Heng; Botstein David; Cherry J Michael; Sherlock Gavin
GO::TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes.
Bioinformatics (Oxford, England) 2004;20(18):3710-5.
2004: Rees Christian A; Demeter Janos; Matese John C; Botstein David; Sherlock Gavin
GeneXplorer: an interactive web application for microarray data visualization and analysis.
BMC bioinformatics 2004;5():141.
2004: Tu I-Ping; Schaner Marci; Diehn Maximilian; Sikic Branimir I; Brown Patrick O; Botstein David; Fero Michael J
A method for detecting and correcting feature misidentification on expression microarrays.
BMC genomics 2004;5(1):64.
2004: Saldanha Alok J; Brauer Matthew J; Botstein David
Nutritional homeostasis in batch and steady-state culture of yeast.
Molecular biology of the cell 2004;15(9):4089-104.
2004: Zhao Hongjuan; Langerød Anita; Ji Youngran; Nowels Kent W; Nesland Jahn M; Tibshirani Rob; Bukholm Ida K; Kåresen Rolf; Botstein David; Børresen-Dale Anne-Lise; Jeffrey Stefanie S
Different gene expression patterns in invasive lobular and ductal carcinomas of the breast.
Molecular biology of the cell 2004;15(6):2523-36.
2004: Murray John Isaac; Whitfield Michael L; Trinklein Nathan D; Myers Richard M; Brown Patrick O; Botstein David
Diverse and specific gene expression responses to stresses in cultured human cells.
Molecular biology of the cell 2004;15(5):2361-74.
2004: Lossos Izidore S; Czerwinski Debra K; Alizadeh Ash A; Wechser Mark A; Tibshirani Rob; Botstein David; Levy Ronald
Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes.
The New England journal of medicine 2004;350(18):1828-37.
2004: Dwight Selina S; Balakrishnan Rama; Christie Karen R; Costanzo Maria C; Dolinski Kara; Engel Stacia R; Feierbach Becket; Fisk Dianna G; Hirschman Jodi; Hong Eurie L; Issel-Tarver Laurie; Nash Robert S; Sethuraman Anand; Starr Barry; Theesfeld Chandra L; Andrada Rey; Binkley Gail; Dong Qing; Lane Christopher; Schroeder Mark; Weng Shuai; Botstein David; Cherry J Michael
Saccharomyces genome database: underlying principles and organisation.
Briefings in bioinformatics 2004;5(1):9-22.
2004: Novoradovskaya Natalia; Whitfield Michael L; Basehore Lee S; Novoradovsky Alexey; Pesich Robert; Usary Jerry; Karaca Mehmet; Wong Winston K; Aprelikova Olga; Fero Michael; Perou Charles M; Botstein David; Braman Jeff
Universal Reference RNA as a standard for microarray experiments.
BMC genomics 2004;5(1):20.
2004: Shakoury-Elizeh Minoo; Tiedeman John; Rashford Jared; Ferea Tracey; Demeter Janos; Garcia Emily; Rolfes Ronda; Brown Patrick O; Botstein David; Philpott Caroline C
Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae.
Molecular biology of the cell 2004;15(3):1233-43.
2004: Trinklein Nathan D; Murray John I; Hartman Sara J; Botstein David; Myers Richard M
The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response.
Molecular biology of the cell 2004;15(3):1254-61.
2004: Botstein David
Ira Herskowitz: 1946-2003.
Genetics 2004;166(2):653-60.
2004: Bialek William; Botstein David
Introductory science and mathematics education for 21st-Century biologists.
Science (New York, N.Y.) 2004;303(5659):788-90.
2004: Chang Howard Y; Sneddon Julie B; Alizadeh Ash A; Sood Ruchira; West Rob B; Montgomery Kelli; Chi Jen-Tsan; van de Rijn Matt; Botstein David; Brown Patrick O
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
PLoS biology 2004;2(2):E7.
2004: Zhao Hongjuan; Whitfield Michael L; Xu Tong; Botstein David; Brooks James D
Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells.
Molecular biology of the cell 2004;15(2):506-19.
2004: Lapointe Jacques; Li Chunde; Higgins John P; van de Rijn Matt; Bair Eric; Montgomery Kelli; Ferrari Michelle; Egevad Lars; Rayford Walter; Bergerheim Ulf; Ekman Peter; DeMarzo Angelo M; Tibshirani Robert; Botstein David; Brown Patrick O; Brooks James D; Pollack Jonathan R
Gene expression profiling identifies clinically relevant subtypes of prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):811-6.
2004: Christie Karen R; Weng Shuai; Balakrishnan Rama; Costanzo Maria C; Dolinski Kara; Dwight Selina S; Engel Stacia R; Feierbach Becket; Fisk Dianna G; Hirschman Jodi E; Hong Eurie L; Issel-Tarver Laurie; Nash Robert; Sethuraman Anand; Starr Barry; Theesfeld Chandra L; Andrada Rey; Binkley Gail; Dong Qing; Lane Christopher; Schroeder Mark; Botstein David; Cherry J Michael
Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms.
Nucleic acids research 2004;32(Database issue):D311-4.
2003: Linn Sabine C; West Rob B; Pollack Jonathan R; Zhu Shirley; Hernandez-Boussard Tina; Nielsen Torsten O; Rubin Brian P; Patel Rajiv; Goldblum John R; Siegmund David; Botstein David; Brown Patrick O; Gilks C Blake; van de Rijn Matt
Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans.
The American journal of pathology 2003;163(6):2383-95.
2003: Roose Jeroen P; Diehn Maximilian; Tomlinson Michael G; Lin Joseph; Alizadeh Ash A; Botstein David; Brown Patrick O; Weiss Arthur
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.
PLoS biology 2003;1(2):E53.
2003: Schaner Marci E; Ross Douglas T; Ciaravino Giuseppe; Sorlie Therese; Troyanskaya Olga; Diehn Maximilian; Wang Yan C; Duran George E; Sikic Thomas L; Caldeira Sandra; Skomedal Hanne; Tu I-Ping; Hernandez-Boussard Tina; Johnson Steven W; O'Dwyer Peter J; Fero Michael J; Kristensen Gunnar B; Borresen-Dale Anne-Lise; Hastie Trevor; Tibshirani Robert; van de Rijn Matt; Teng Nelson N; Longacre Teri A; Botstein David; Brown Patrick O; Sikic Branimir I
Gene expression patterns in ovarian carcinomas.
Molecular biology of the cell 2003;14(11):4376-86.
2003: Whitfield Michael L; Finlay Deborah R; Murray John Isaac; Troyanskaya Olga G; Chi Jen-Tsan; Pergamenschikov Alexander; McCalmont Timothy H; Brown Patrick O; Botstein David; Connolly M Kari
Systemic and cell type-specific gene expression patterns in scleroderma skin.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12319-24.
2003: Nielsen Torsten O; Hsu Forrest D; O'Connell John X; Gilks C Blake; Sorensen Poul H B; Linn Sabine; West Robert B; Liu Chih Long; Botstein David; Brown Patrick O; van de Rijn Matt
Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology.
The American journal of pathology 2003;163(4):1449-56.
2003: Chi Jen-Tsan; Chang Howard Y; Haraldsen Guttorm; Jahnsen Frode L; Troyanskaya Olga G; Chang Dustin S; Wang Zhen; Rockson Stanley G; van de Rijn Matt; Botstein David; Brown Patrick O
Endothelial cell diversity revealed by global expression profiling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10623-8.
2003: Smith Kevin S; Chanda Sumit K; Lingbeek Merel; Ross Douglas T; Botstein David; van Lohuizen Maarten; Cleary Michael L
Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.
Molecular cell 2003;12(2):393-400.
2003: Chen Xin; Leung Suet Y; Yuen Siu T; Chu Kent-Man; Ji Jiafu; Li Rui; Chan Annie S Y; Law Simon; Troyanskaya Olga G; Wong John; So Samuel; Botstein David; Brown Patrick O
Variation in gene expression patterns in human gastric cancers.
Molecular biology of the cell 2003;14(8):3208-15.
2003: Sorlie Therese; Tibshirani Robert; Parker Joel; Hastie Trevor; Marron J S; Nobel Andrew; Deng Shibing; Johnsen Hilde; Pesich Robert; Geisler Stephanie; Demeter Janos; Perou Charles M; Lønning Per E; Brown Patrick O; Børresen-Dale Anne-Lise; Botstein David
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8418-23.
2003: Troyanskaya Olga G; Dolinski Kara; Owen Art B; Altman Russ B; Botstein David
A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae).
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8348-53.
2003: Segal Eran; Shapira Michael; Regev Aviv; Pe'er Dana; Botstein David; Koller Daphne; Friedman Nir
Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data.
Nature genetics 2003;34(2):166-76.
2003: Alter Orly; Brown Patrick O; Botstein David
Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3351-6.
2003: Uhlmann Wendy R; Bennett Robin; Botkin Jeffrey R; Botstein David; Boughman Joann A; Chakravarti Aravinda; Clayton Ellen Wright; Kahn Jeffrey; Koenig Barbara; Murray Thomas H; Olson Maynard V; Rowley Janet; Terry Sharon; Valle David
Planning the genome institute's future.
Science (New York, N.Y.) 2003;299(5612):1515; author reply 1515.
2003: Botstein David; Risch Neil
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease.
Nature genetics 2003;33 Suppl():228-37.
2003: Bohen Sean P; Troyanskaya Olga G; Alter Orly; Warnke Roger; Botstein David; Brown Patrick O; Levy Ronald
Variation in gene expression patterns in follicular lymphoma and the response to rituximab.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1926-30.
2003: Ranade Koustubh; Hinds David; Hsiung Chao Agnes; Chuang Lee-Ming; Chang Mau-Song; Chen Ying-Tsung; Pesich Robert; Hebert Joan; Chen Yii-Der I; Dzau Victor; Olshen Richard; Curb David; Botstein David; Cox David R; Risch Neil
A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.
American journal of hypertension 2003;16(2):158-62.
2003: Diehn Maximilian; Sherlock Gavin; Binkley Gail; Jin Heng; Matese John C; Hernandez-Boussard Tina; Rees Christian A; Cherry J Michael; Botstein David; Brown Patrick O; Alizadeh Ash A
SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data.
Nucleic acids research 2003;31(1):219-23.
2003: Weng Shuai; Dong Qing; Balakrishnan Rama; Christie Karen; Costanzo Maria; Dolinski Kara; Dwight Selina S; Engel Stacia; Fisk Dianna G; Hong Eurie; Issel-Tarver Laurie; Sethuraman Anand; Theesfeld Chandra; Andrada Rey; Binkley Gail; Lane Christopher; Schroeder Mark; Botstein David; Michael Cherry J
Saccharomyces Genome Database (SGD) provides biochemical and structural information for budding yeast proteins.
Nucleic acids research 2003;31(1):216-8.
2003: Gollub Jeremy; Ball Catherine A; Binkley Gail; Demeter Janos; Finkelstein David B; Hebert Joan M; Hernandez-Boussard Tina; Jin Heng; Kaloper Miroslava; Matese John C; Schroeder Mark; Brown Patrick O; Botstein David; Sherlock Gavin
The Stanford Microarray Database: data access and quality assessment tools.
Nucleic acids research 2003;31(1):94-6.
2003: Botstein D
Genomic perspective and cancer.
Cold Spring Harbor symposia on quantitative biology 2003;68():417-24.
2002: Wang Wei; Cherry J Michael; Botstein David; Li Hao
A systematic approach to reconstructing transcription networks in Saccharomycescerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16893-8.
2002: van de Rijn Matt; Perou Charles M; Tibshirani Rob; Haas Phillippe; Kallioniemi Olli; Kononen Juha; Torhorst Joachim; Sauter Guido; Zuber Markus; Köchli Ossi R; Mross Frank; Dieterich Holger; Seitz Rob; Ross Doug; Botstein David; Brown Pat
Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome.
The American journal of pathology 2002;161(6):1991-6.
2002: Leung Suet Y; Chen Xin; Chu Kent M; Yuen Siu T; Mathy Jonathan; Ji Jiafu; Chan Annie S Y; Li Rui; Law Simon; Troyanskaya Olga G; Tu I-Ping; Wong John; So Samuel; Botstein David; Brown Patrick O
Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):16203-8.
2002: Dunham Maitreya J; Badrane Hassan; Ferea Tracy; Adams Julian; Brown Patrick O; Rosenzweig Frank; Botstein David
Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):16144-9.
2002: Troyanskaya Olga G; Garber Mitchell E; Brown Patrick O; Botstein David; Altman Russ B
Nonparametric methods for identifying differentially expressed genes in microarray data.
Bioinformatics (Oxford, England) 2002;18(11):1454-61.
2002: Trotter Eleanor W; Kao Camilla M-F; Berenfeld Ludmilla; Botstein David; Petsko Gregory A; Gray Joseph V
Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae.
The Journal of biological chemistry 2002;277(47):44817-25.
2002: Chang Howard Y; Chi Jen-Tsan; Dudoit Sandrine; Bondre Chanda; van de Rijn Matt; Botstein David; Brown Patrick O
Diversity, topographic differentiation, and positional memory in human fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12877-82.
2002: Pollack Jonathan R; Sørlie Therese; Perou Charles M; Rees Christian A; Jeffrey Stefanie S; Lonning Per E; Tibshirani Robert; Botstein David; Børresen-Dale Anne-Lise; Brown Patrick O
Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12963-8.
2002: Diehn Maximilian; Alizadeh Ash A; Rando Oliver J; Liu Chih Long; Stankunas Kryn; Botstein David; Crabtree Gerald R; Brown Patrick O
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11796-801.
2002: Yoshimoto Hiroyuki; Saltsman Kirstie; Gasch Audrey P; Li Hong Xia; Ogawa Nobuo; Botstein David; Brown Patrick O; Cyert Martha S
Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae.
The Journal of biological chemistry 2002;277(34):31079-88.
2002: Sayama Koichi; Diehn Maximilian; Matsuda Kentaro; Lunderius Carolina; Tsai Mindy; Tam See-Ying; Botstein David; Brown Patrick O; Galli Stephen J
Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11.
BMC immunology 2002;3():5.
2002: Lossos Izidore S; Alizadeh Ash A; Diehn Maximilian; Warnke Roger; Thorstenson Yvonne; Oefner Peter J; Brown Patrick O; Botstein David; Levy Ronald
Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8886-91.
2002: Pollack Jonathan R; Van de Rijn Matt; Botstein David
Challenges in developing a molecular characterization of cancer.
Seminars in oncology 2002;29(3):280-5.
2002: Whitfield Michael L; Sherlock Gavin; Saldanha Alok J; Murray John I; Ball Catherine A; Alexander Karen E; Matese John C; Perou Charles M; Hurt Myra M; Brown Patrick O; Botstein David
Identification of genes periodically expressed in the human cell cycle and their expression in tumors.
Molecular biology of the cell 2002;13(6):1977-2000.
2002: Chen Xin; Cheung Siu Tim; So Samuel; Fan Sheung Tat; Barry Christopher; Higgins John; Lai Kin-Man; Ji Jiafu; Dudoit Sandrine; Ng Irene O L; Van De Rijn Matt; Botstein David; Brown Patrick O
Gene expression patterns in human liver cancers.
Molecular biology of the cell 2002;13(6):1929-39.
2002: Click Eleanor S; Stearns Tim; Botstein David
Systematic structure-function analysis of the small GTPase Arf1 in yeast.
Molecular biology of the cell 2002;13(5):1652-64.
2002: Jeffrey Stefanie S; Fero Michael J; Børresen-Dale Anne-Lise; Botstein David
Expression array technology in the diagnosis and treatment of breast cancer.
Molecular interventions 2002;2(2):101-9.
2002: Nielsen Torsten O; West Rob B; Linn Sabine C; Alter Orly; Knowling Margaret A; O'Connell John X; Zhu Shirley; Fero Mike; Sherlock Gavin; Pollack Jonathan R; Brown Patrick O; Botstein David; van de Rijn Matt
Molecular characterisation of soft tissue tumours: a gene expression study.
Lancet 2002;359(9314):1301-7.
2002: Ranade Koustubh; Jorgenson Eric; Sheu Wayne H-H; Pei Dee; Hsiung Chao Agnes; Chiang Fu-tien; Chen Yii-der I; Pratt Richard; Olshen Richard A; Curb David; Cox David R; Botstein David; Risch Neil
A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.
American journal of human genetics 2002;70(4):935-42.
2002: Boldrick Jennifer C; Alizadeh Ash A; Diehn Maximilian; Dudoit Sandrine; Liu Chih Long; Belcher Christopher E; Botstein David; Staudt Louis M; Brown Patrick O; Relman David A
Stereotyped and specific gene expression programs in human innate immune responses to bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):972-7.
2002: Dwight Selina S; Harris Midori A; Dolinski Kara; Ball Catherine A; Binkley Gail; Christie Karen R; Fisk Dianna G; Issel-Tarver Laurie; Schroeder Mark; Sherlock Gavin; Sethuraman Anand; Weng Shuai; Botstein David; Cherry J Michael
Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO).
Nucleic acids research 2002;30(1):69-72.
2002: Mulholland Jon; Botstein David
Immunoelectron microscopy of aldehyde-fixed yeast cells.
Methods in enzymology 2002;351():50-81.
2002: Issel-Tarver Laurie; Christie Karen R; Dolinski Kara; Andrada Rey; Balakrishnan Rama; Ball Catherine A; Binkley Gail; Dong Stan; Dwight Selina S; Fisk Dianna G; Harris Midori; Schroeder Mark; Sethuraman Anand; Tse Kane; Weng Shuai; Botstein David; Cherry J Michael
Saccharomyces Genome Database.
Methods in enzymology 2002;350():329-46.
2001: Ranade K; Shue W H; Hung Y J; Hsuing C A; Chiang F T; Pesich R; Hebert J; Olivier M; Chen Y D; Pratt R; Olshen R; Curb D; Botstein D; Risch N; Cox D R
The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin.
American journal of hypertension 2001;14(12):1196-200.
2001: Anders K R; Botstein D
Dominant-lethal alpha-tubulin mutants defective in microtubule depolymerization in yeast.
Molecular biology of the cell 2001;12(12):3973-86.
2001: Protchenko O; Ferea T; Rashford J; Tiedeman J; Brown P O; Botstein D; Philpott C C
Three cell wall mannoproteins facilitate the uptake of iron in Saccharomyces cerevisiae.
The Journal of biological chemistry 2001;276(52):49244-50.
2001: Garber M E; Troyanskaya O G; Schluens K; Petersen S; Thaesler Z; Pacyna-Gengelbach M; van de Rijn M; Rosen G D; Perou C M; Whyte R I; Altman R B; Brown P O; Botstein D; Petersen I
Diversity of gene expression in adenocarcinoma of the lung.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13784-9.
2001: Ranade K; Wu K D; Risch N; Olivier M; Pei D; Hsiao C F; Chuang L M; Ho L T; Jorgenson E; Pesich R; Chen Y D; Dzau V; Lin A; Olshen R A; Curb D; Cox D R; Botstein D
Genetic variation in aldosterone synthase predicts plasma glucose levels.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13219-24.
2001: Gasch A P; Huang M; Metzner S; Botstein D; Elledge S J; Brown P O
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.
Molecular biology of the cell 2001;12(10):2987-3003.
2001: Ranade K; Wu K D; Hwu C M; Ting C T; Pei D; Pesich R; Hebert J; Chen Y D; Pratt R; Olshen R; Masaki K; Risch N; Cox D R; Botstein D
Genetic variation in the human urea transporter-2 is associated with variation in blood pressure.
Human molecular genetics 2001;10(19):2157-64.
2001: Lønning P E; Sørlie T; Perou C M; Brown P O; Botstein D; Børresen-Dale A L
Microarrays in primary breast cancer--lessons from chemotherapy studies.
Endocrine-related cancer 2001;8(3):259-63.
2001: Sørlie T; Perou C M; Tibshirani R; Aas T; Geisler S; Johnsen H; Hastie T; Eisen M B; van de Rijn M; Jeffrey S S; Thorsen T; Quist H; Matese J C; Brown P O; Botstein D; Eystein Lønning P; Børresen-Dale A L
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10869-74.
2001: Lieb J D; Liu X; Botstein D; Brown P O
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association.
Nature genetics 2001;28(4):327-34.
2001: Ranade K; Chang M S; Ting C T; Pei D; Hsiao C F; Olivier M; Pesich R; Hebert J; Chen Y D; Dzau V J; Curb D; Olshen R; Risch N; Cox D R; Botstein D
High-throughput genotyping with single nucleotide polymorphisms.
Genome research 2001;11(7):1262-8.
2001: Troyanskaya O; Cantor M; Sherlock G; Brown P; Hastie T; Tibshirani R; Botstein D; Altman R B
Missing value estimation methods for DNA microarrays.
Bioinformatics (Oxford, England) 2001;17(6):520-5.
2001: Carmel-Harel O; Stearman R; Gasch A P; Botstein D; Brown P O; Storz G
Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae.
Molecular microbiology 2001;39(3):595-605.
2001: Iyer V R; Horak C E; Scafe C S; Botstein D; Snyder M; Brown P O
Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF.
Nature 2001;409(6819):533-8.
2001: Sherlock G; Hernandez-Boussard T; Kasarskis A; Binkley G; Matese J C; Dwight S S; Kaloper M; Weng S; Jin H; Ball C A; Eisen M B; Spellman P T; Brown P O; Botstein D; Cherry J M
The Stanford Microarray Database.
Nucleic acids research 2001;29(1):152-5.
2001: Ball C A; Jin H; Sherlock G; Weng S; Matese J C; Andrada R; Binkley G; Dolinski K; Dwight S S; Harris M A; Issel-Tarver L; Schroeder M; Botstein D; Cherry J M
Saccharomyces Genome Database provides tools to survey gene expression and functional analysis data.
Nucleic acids research 2001;29(1):80-1.
2001: Hastie T; Tibshirani R; Botstein D; Brown P
Supervised harvesting of expression trees.
Genome biology 2001;2(1):RESEARCH0003.
2000: Gasch A P; Spellman P T; Kao C M; Carmel-Harel O; Eisen M B; Storz G; Botstein D; Brown P O
Genomic expression programs in the response of yeast cells to environmental changes.
Molecular biology of the cell 2000;11(12):4241-57.
2000: Khodursky A B; Peter B J; Cozzarelli N R; Botstein D; Brown P O; Yanofsky C
DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12170-5.
2000: Alter O; Brown P O; Botstein D
Singular value decomposition for genome-wide expression data processing and modeling.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10101-6.
2000: Perou C M; Sørlie T; Eisen M B; van de Rijn M; Jeffrey S S; Rees C A; Pollack J R; Ross D T; Johnsen H; Akslen L A; Fluge O; Pergamenschikov A; Williams C; Zhu S X; Lønning P E; Børresen-Dale A L; Brown P O; Botstein D
Molecular portraits of human breast tumours.
Nature 2000;406(6797):747-52.
2000: Khodursky A B; Peter B J; Schmid M B; DeRisi J; Botstein D; Brown P O; Cozzarelli N R
Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9419-24.
2000: Zhu G; Spellman P T; Volpe T; Brown P O; Botstein D; Davis T N; Futcher B
Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth.
Nature 2000;406(6791):90-4.
2000: Ranade K; Hsuing A C; Wu K D; Chang M S; Chen Y T; Hebert J; Chen Y I; Olshen R; Curb D; Dzau V; Botstein D; Cox D; Risch N
Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations.
American journal of hypertension 2000;13(6 Pt 1):704-9.
2000: Diehn M; Eisen M B; Botstein D; Brown P O
Large-scale identification of secreted and membrane-associated gene products using DNA microarrays.
Nature genetics 2000;25(1):58-62.
2000: Ashburner M; Ball C A; Blake J A; Botstein D; Butler H; Cherry J M; Davis A P; Dolinski K; Dwight S S; Eppig J T; Harris M A; Hill D P; Issel-Tarver L; Kasarskis A; Lewis S; Matese J C; Richardson J E; Ringwald M; Rubin G M; Sherlock G
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.
Nature genetics 2000;25(1):25-9.
2000: Richards K L; Anders K R; Nogales E; Schwartz K; Downing K H; Botstein D
Structure-function relationships in yeast tubulins.
Molecular biology of the cell 2000;11(5):1887-903.
2000: Yun C W; Ferea T; Rashford J; Ardon O; Brown P O; Botstein D; Kaplan J; Philpott C C
Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake.
The Journal of biological chemistry 2000;275(14):10709-15.
2000: Scherf U; Ross D T; Waltham M; Smith L H; Lee J K; Tanabe L; Kohn K W; Reinhold W C; Myers T G; Andrews D T; Scudiero D A; Eisen M B; Sausville E A; Pommier Y; Botstein D; Brown P O; Weinstein J N
A gene expression database for the molecular pharmacology of cancer.
Nature genetics 2000;24(3):236-44.
2000: Ross D T; Scherf U; Eisen M B; Perou C M; Rees C; Spellman P; Iyer V; Jeffrey S S; Van de Rijn M; Waltham M; Pergamenschikov A; Lee J C; Lashkari D; Shalon D; Myers T G; Weinstein J N; Botstein D; Brown P O
Systematic variation in gene expression patterns in human cancer cell lines.
Nature genetics 2000;24(3):227-35.
2000: Friddle C; Koskela R; Ranade K; Hebert J; Cargill M; Clark C D; McInnis M; Simpson S; McMahon F; Stine O C; Meyers D; Xu J; MacKinnon D; Swift-Scanlan T; Jamison K; Folstein S; Daly M; Kruglyak L; Marr T; DePaulo J R; Botstein D
Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.
American journal of human genetics 2000;66(1):205-15.
2000: Ball C A; Dolinski K; Dwight S S; Harris M A; Issel-Tarver L; Kasarskis A; Scafe C R; Sherlock G; Binkley G; Jin H; Kaloper M; Orr S D; Schroeder M; Weng S; Zhu Y; Botstein D; Cherry J M
Integrating functional genomic information into the Saccharomyces genome database.
Nucleic acids research 2000;28(1):77-80.
2000: Lee S E; Pellicioli A; Demeter J; Vaze M P; Gasch A P; Malkova A; Brown P O; Botstein D; Stearns T; Foiani M; Haber J E
Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae.
Cold Spring Harbor symposia on quantitative biology 2000;65():303-14.
2000: Hastie T; Tibshirani R; Eisen M B; Alizadeh A; Levy R; Staudt L; Chan W C; Botstein D; Brown P
'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns.
Genome biology 2000;1(2):RESEARCH0003.
1999: Pollack J R; Perou C M; Alizadeh A A; Eisen M B; Pergamenschikov A; Williams C F; Jeffrey S S; Botstein D; Brown P O
Genome-wide analysis of DNA copy-number changes using cDNA microarrays.
Nature genetics 1999;23(1):41-6.
1999: Ferea T L; Botstein D; Brown P O; Rosenzweig R F
Systematic changes in gene expression patterns following adaptive evolution in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9721-6.
1999: Perou C M; Jeffrey S S; van de Rijn M; Rees C A; Eisen M B; Ross D T; Pergamenschikov A; Williams C F; Zhu S X; Lee J C; Lashkari D; Shalon D; Brown P O; Botstein D
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9212-7.
1999: Mulholland J; Konopka J; Singer-Kruger B; Zerial M; Botstein D
Visualization of receptor-mediated endocytosis in yeast.
Molecular biology of the cell 1999;10(3):799-817.
1999: Brown P O; Botstein D
Exploring the new world of the genome with DNA microarrays.
Nature genetics 1999;21(1 Suppl):33-7.
1999: Iyer V R; Eisen M B; Ross D T; Schuler G; Moore T; Lee J C; Trent J M; Staudt L M; Hudson J; Boguski M S; Lashkari D; Shalon D; Botstein D; Brown P O
The transcriptional program in the response of human fibroblasts to serum.
Science (New York, N.Y.) 1999;283(5398):83-7.
1999: Chervitz S A; Hester E T; Ball C A; Dolinski K; Dwight S S; Harris M A; Juvik G; Malekian A; Roberts S; Roe T; Scafe C; Schroeder M; Sherlock G; Weng S; Zhu Y; Cherry J M; Botstein D
Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure.
Nucleic acids research 1999;27(1):74-8.
1999: Alizadeh A; Eisen M; Davis R E; Ma C; Sabet H; Tran T; Powell J I; Yang L; Marti G E; Moore D T; Hudson J R; Chan W C; Greiner T; Weisenburger D; Armitage J O; Lossos I; Levy R; Botstein D; Brown P O; Staudt L M
The lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes.
Cold Spring Harbor symposia on quantitative biology 1999;64():71-8.
1998: Dolinski K; Ball C A; Chervitz S A; Dwight S S; Harris M A; Roberts S; Roe T; Cherry J M; Botstein D
Expanding yeast knowledge online.
Yeast (Chichester, England) 1998;14(16):1453-69.
1998: Chervitz S A; Aravind L; Sherlock G; Ball C A; Koonin E V; Dwight S S; Harris M A; Dolinski K; Mohr S; Smith T; Weng S; Cherry J M; Botstein D
Comparison of the complete protein sets of worm and yeast: orthology and divergence.
Science (New York, N.Y.) 1998;282(5396):2022-8.
1998: Eisen M B; Spellman P T; Brown P O; Botstein D
Cluster analysis and display of genome-wide expression patterns.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14863-8.
1998: Spellman P T; Sherlock G; Zhang M Q; Iyer V R; Anders K; Eisen M B; Brown P O; Botstein D; Futcher B
Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization.
Molecular biology of the cell 1998;9(12):3273-97.
1998: Alizadeh A; Eisen M; Botstein D; Brown P O; Staudt L M
Probing lymphocyte biology by genomic-scale gene expression analysis.
Journal of clinical immunology 1998;18(6):373-9.
1998: Chu S; DeRisi J; Eisen M; Mulholland J; Botstein D; Brown P O; Herskowitz I
The transcriptional program of sporulation in budding yeast.
Science (New York, N.Y.) 1998;282(5389):699-705.
1998: Cherry J M; Adler C; Ball C; Chervitz S A; Dwight S S; Hester E T; Jia Y; Juvik G; Roe T; Schroeder M; Weng S; Botstein D
SGD: Saccharomyces Genome Database.
Nucleic acids research 1998;26(1):73-9.
1997: Schwartz K; Richards K; Botstein D
BIM1 encodes a microtubule-binding protein in yeast.
Molecular biology of the cell 1997;8(12):2677-91.
1997: Botstein D; Chervitz S A; Cherry J M
Yeast as a model organism.
Science (New York, N.Y.) 1997;277(5330):1259-60.
1997: Mulholland J; Wesp A; Riezman H; Botstein D
Yeast actin cytoskeleton mutants accumulate a new class of Golgi-derived secretary vesicle.
Molecular biology of the cell 1997;8(8):1481-99.
1997: Cherry J M; Ball C; Weng S; Juvik G; Schmidt R; Adler C; Dunn B; Dwight S; Riles L; Mortimer R K; Botstein D
Genetic and physical maps of Saccharomyces cerevisiae.
Nature 1997;387(6632 Suppl):67-73.
1997: Amberg D C; Zahner J E; Mulholland J W; Pringle J R; Botstein D
Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites.
Molecular biology of the cell 1997;8(4):729-53.
1996: Smith V; Chou K N; Lashkari D; Botstein D; Brown P O
Functional analysis of the genes of yeast chromosome V by genetic footprinting.
Science (New York, N.Y.) 1996;274(5295):2069-74.
1996: Gschwend M; Levran O; Kruglyak L; Ranade K; Verlander P C; Shen S; Faure S; Weissenbach J; Altay C; Lander E S; Auerbach A D; Botstein D
A locus for Fanconi anemia on 16q determined by homozygosity mapping.
American journal of human genetics 1996;59(2):377-84.
1996: Doyle T; Botstein D
Movement of yeast cortical actin cytoskeleton visualized in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):3886-91.
1995: Amberg D C; Botstein D; Beasley E M
Precise gene disruption in Saccharomyces cerevisiae by double fusion polymerase chain reaction.
Yeast (Chichester, England) 1995;11(13):1275-80.
1995: Smith V; Botstein D; Brown P O
Genetic footprinting: a genomic strategy for determining a gene's function given its sequence.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6479-83.
1995: Amberg D C; Basart E; Botstein D
Defining protein interactions with yeast actin in vivo.
Nature structural biology 1995;2(1):28-35.
1994: Ohya Y; Botstein D
Structure-based systematic isolation of conditional-lethal mutations in the single yeast calmodulin gene.
Genetics 1994;138(4):1041-54.
1994: Qadota H; Anraku Y; Botstein D; Ohya Y
Conditional lethality of a yeast strain expressing human RHOA in place of RHO1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9317-21.
1994: Mulholland J; Preuss D; Moon A; Wong A; Drubin D; Botstein D
Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane.
The Journal of cell biology 1994;125(2):381-91.
1994: Clark C D; Palzkill T; Botstein D
Systematic mutagenesis of the yeast mating pheromone receptor third intracellular loop.
The Journal of biological chemistry 1994;269(12):8831-41.
1994: Ohya Y; Botstein D
Diverse essential functions revealed by complementing yeast calmodulin mutants.
Science (New York, N.Y.) 1994;263(5149):963-6.
1993: Ziman M; Preuss D; Mulholland J; O'Brien J M; Botstein D; Johnson D I
Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.
Molecular biology of the cell 1993;4(12):1307-16.
1993: Chan C S; Botstein D
Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.
Genetics 1993;135(3):677-91.
1993: Ohya Y; Qadota H; Anraku Y; Pringle J R; Botstein D
Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p.
Molecular biology of the cell 1993;4(10):1017-25.
1993: Dunn B; Stearns T; Botstein D
Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4.
Nature 1993;362(6420):563-5.
1992: Palzkill T; Botstein D
Probing beta-lactamase structure and function using random replacement mutagenesis.
Proteins 1992;14(1):29-44.
1992: Palzkill T; Botstein D
Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase.
Journal of bacteriology 1992;174(16):5237-43.
1992: Manolson M F; Proteau D; Preston R A; Stenbit A; Roberts B T; Hoyt M A; Preuss D; Mulholland J; Botstein D; Jones E W
The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase.
The Journal of biological chemistry 1992;267(20):14294-303.
1992: Preuss D; Mulholland J; Franzusoff A; Segev N; Botstein D
Characterization of the Saccharomyces Golgi complex through the cell cycle by immunoelectron microscopy.
Molecular biology of the cell 1992;3(7):789-803.
1992: Kron S J; Drubin D G; Botstein D; Spudich J A
Yeast actin filaments display ATP-dependent sliding movement over surfaces coated with rabbit muscle myosin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4466-70.
1992: Barnes G; Louie K A; Botstein D
Yeast proteins associated with microtubules in vitro and in vivo.
Molecular biology of the cell 1992;3(1):29-47.
1991: Adams A E; Botstein D; Drubin D G
Requirement of yeast fimbrin for actin organization and morphogenesis in vivo.
Nature 1991;354(6352):404-8.
1991: Preuss D; Mulholland J; Kaiser C A; Orlean P; Albright C; Rose M D; Robbins P W; Botstein D
Structure of the yeast endoplasmic reticulum: localization of ER proteins using immunofluorescence and immunoelectron microscopy.
Yeast (Chichester, England) 1991;7(9):891-911.
1991: Hennessy K M; Lee A; Chen E; Botstein D
A group of interacting yeast DNA replication genes.
Genes & development 1991;5(6):958-69.
1991: Hennessy K M; Botstein D
Regulation of DNA replication during the yeast cell cycle.
Cold Spring Harbor symposia on quantitative biology 1991;56():279-84.
1990: Hennessy K M; Clark C D; Botstein D
Subcellular localization of yeast CDC46 varies with the cell cycle.
Genes & development 1990;4(12B):2252-63.
1990: Stearns T; Kahn R A; Botstein D; Hoyt M A
ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes.
Molecular and cellular biology 1990;10(12):6690-9.
1990: Botstein D
1989 Allen Award address: the American Society of Human Genetics annual meeting, Baltimore.
American journal of human genetics 1990;47(6):887-91.
1990: Kaiser C A; Botstein D
Efficiency and diversity of protein localization by random signal sequences.
Molecular and cellular biology 1990;10(6):3163-73.
1990: Stearns T; Hoyt M A; Botstein D
Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function.
Genetics 1990;124(2):251-62.
1990: Stearns T; Willingham M C; Botstein D; Kahn R A
ADP-ribosylation factor is functionally and physically associated with the Golgi complex.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):1238-42.
1990: Kunes S; Botstein D; Fox M S
Synapsis-mediated fusion of free DNA ends forms inverted dimer plasmids in yeast.
Genetics 1990;124(1):67-80.
1990: Drubin D G; Mulholland J; Zhu Z M; Botstein D
Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I.
Nature 1990;343(6255):288-90.
1990: Hoyt M A; Stearns T; Botstein D
Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes.
Molecular and cellular biology 1990;10(1):223-34.
1989: Ma H; Bloom L M; Walsh C T; Botstein D
The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae.
Molecular and cellular biology 1989;9(12):5643-9.
1989: Ma H; Bloom L M; Zhu Z M; Walsh C T; Botstein D
Isolation and characterization of mutations in the HXK2 gene of Saccharomyces cerevisiae.
Molecular and cellular biology 1989;9(12):5630-42.
1989: Preuss D; Botstein D
Intragenic revertants of yeast invertase variants with secretion-defective leader sequences.
Molecular and cellular biology 1989;9(4):1452-64.
1989: Adams A E; Botstein D
Dominant suppressors of yeast actin mutations that are reciprocally suppressed.
Genetics 1989;121(4):675-83.
1989: Novick P; Osmond B C; Botstein D
Suppressors of yeast actin mutations.
Genetics 1989;121(4):659-74.
1989: Adams A E; Botstein D; Drubin D G
A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation.
Science (New York, N.Y.) 1989;243(4888):231-3.
1989: Lander E S; Botstein D
Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.
Genetics 1989;121(1):185-99.
1989: Ma H; Bloom L M; Dakin S E; Walsh C T; Botstein D
The 15 N-terminal amino acids of hexokinase II are not required for in vivo function: analysis of a truncated form of hexokinase II in Saccharomyces cerevisiae.
Proteins 1989;5(3):218-23.
1988: Drubin D G; Miller K G; Botstein D
Yeast actin-binding proteins: evidence for a role in morphogenesis.
The Journal of cell biology 1988;107(6 Pt 2):2551-61.
1988: Schatz P J; Solomon F; Botstein D
Isolation and characterization of conditional-lethal mutations in the TUB1 alpha-tubulin gene of the yeast Saccharomyces cerevisiae.
Genetics 1988;120(3):681-95.
1988: Stearns T; Botstein D
Unlinked noncomplementation: isolation of new conditional-lethal mutations in each of the tubulin genes of Saccharomyces cerevisiae.
Genetics 1988;119(2):249-60.
1988: Huffaker T C; Thomas J H; Botstein D
Diverse effects of beta-tubulin mutations on microtubule formation and function.
The Journal of cell biology 1988;106(6):1997-2010.
1988: Botstein D; Fink G R
Yeast: an experimental organism for modern biology.
Science (New York, N.Y.) 1988;240(4858):1439-43.
1988: Daub E; Zawadzke L E; Botstein D; Walsh C T
Isolation, cloning, and sequencing of the Salmonella typhimurium ddlA gene with purification and characterization of its product, D-alanine:D-alanine ligase (ADP forming).
Biochemistry 1988;27(10):3701-8.
1988: Segev N; Mulholland J; Botstein D
The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery.
Cell 1988;52(6):915-24.
1988: Botstein D; Segev N; Stearns T; Hoyt M A; Holden J; Kahn R A
Diverse biological functions of small GTP-binding proteins in yeast.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():629-36.
1987: Fitts R; Reuveny Z; van Amsterdam J; Mulholland J; Botstein D
Substitution of tyrosine for either cysteine in beta-lactamase prevents release from the membrane during secretion.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8540-3.
1987: Riggs P D; Botstein D
Fusions of bacteriophage P22 late genes to the Escherichia coli lacZ gene.
Journal of virology 1987;61(11):3621-4.
1987: Schatz P J; Georges G E; Solomon F; Botstein D
Insertions of up to 17 amino acids into a region of alpha-tubulin do not disrupt function in vivo.
Molecular and cellular biology 1987;7(10):3799-805.
1987: Kunes S; Ma H; Overbye K; Fox M S; Botstein D
Fine structure recombinational analysis of cloned genes using yeast transformation.
Genetics 1987;115(1):73-81.
1987: Kaiser C A; Preuss D; Grisafi P; Botstein D
Many random sequences functionally replace the secretion signal sequence of yeast invertase.
Science (New York, N.Y.) 1987;235(4786):312-7.
1987: Rose M D; Novick P; Thomas J H; Botstein D; Fink G R
A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector.
Gene 1987;60(2-3):237-43.
1987: Huffaker T C; Hoyt M A; Botstein D
Genetic analysis of the yeast cytoskeleton.
Annual review of genetics 1987;21():259-84.
1987: Ma H; Kunes S; Schatz P J; Botstein D
Plasmid construction by homologous recombination in yeast.
Gene 1987;58(2-3):201-16.
1986: Schatz P J; Solomon F; Botstein D
Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins.
Molecular and cellular biology 1986;6(11):3722-33.
1986: Schatz P J; Pillus L; Grisafi P; Solomon F; Botstein D
Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins.
Molecular and cellular biology 1986;6(11):3711-21.
1984: Kunes S; Botstein D; Fox M S
Formation of inverted dimer plasmids after transformation of yeast with linearized plasmid DNA.
Cold Spring Harbor symposia on quantitative biology 1984;49():617-28.

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