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David Tscharke

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TOP 3
Leon C W Lin; Inge E A Flesch; David C Tscharke
Immunodomination during Peripheral Vaccinia Virus Infection.
Danushka K Wijesundara; David C Tscharke; Ronald J Jackson; Charani Ranasinghe
Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity.
Nathan P Croft; Nadine L Dudek; Inge E A Flesch; Leon C W Lin; Stewart A Smith; Chor Teck Tan; David C Tscharke; Yik Chun Wong; Anthony W Purcell
Kinetics of antigen expression and epitope presentation during virus infection.

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All Publications

2013: Leon C W Lin; Inge E A Flesch; David C Tscharke
Immunodomination during Peripheral Vaccinia Virus Infection.
PLoS pathogens 2013;9(4):e1003329.
2013: Danushka K Wijesundara; David C Tscharke; Ronald J Jackson; Charani Ranasinghe
Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity.
PloS one 2013;8(1):e55788.
2013: Nathan P Croft; Nadine L Dudek; Inge E A Flesch; Leon C W Lin; Stewart A Smith; Chor Teck Tan; David C Tscharke; Yik Chun Wong; Anthony W Purcell
Kinetics of antigen expression and epitope presentation during virus infection.
PLoS pathogens 2013;9(1):e1003129.
2012: Peter J Kerr; Andrew F Read; David C Tscharke; Peter J Hudson; Isabella M Cattadori; Jay V DePasse; Adam Fitch; Elodie Ghedin; Edward C Holmes
Evolutionary history and attenuation of myxoma virus on two continents.
PLoS pathogens 2012;8(10):e1002950.
2012: Inge E A Flesch; Natasha A Hollett; Yik Chun Wong; David C Tscharke
Linear fidelity in quantification of anti-viral CD8+ T cells.
PloS one 2012;7(6):e39533.
2012: Inge E A Flesch; Yik Chun Wong; David C Tscharke
Analyzing CD8 T cells in mouse models of poxvirus infection.
Methods in molecular biology (Clifton, N.J.) 2012;890():199-218.
2012: Leon C W Lin; Stewart A Smith; David C Tscharke
An intradermal model for vaccinia virus pathogenesis in mice.
Methods in molecular biology (Clifton, N.J.) 2012;890():147-59.
2011: Carolina R Melo-Silva; Arno Müllbacher; R Mark Buller; Aulikki Koskinen; Mario Lobigs; David C Tscharke; Yik Chun Wong; Matthias Regner
The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responses.
Journal of virology 2011;85(21):11170-82.
2011: Yik Chun Wong; Leon C W Lin; Carolina R Melo-Silva; Stewart A Smith; David C Tscharke
Engineering recombinant poxviruses using a compact GFP-blasticidin resistance fusion gene for selection.
Journal of virological methods 2011;171(1):295-8.
2008: Ross Tellam; Corey Smith; Michael Rist; Natasha Webb; Leanne Cooper; Tony Vuocolo; Geoff Connolly; David C Tscharke; Michael P Devoy; Rajiv Khanna
Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9319-24.
2008: S M Mansour Haeryfar; Heather D Hickman; Kari R Irvine; David C Tscharke; Jack R Bennink; jon yewdell
Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):649-59.
2008: Carla Oseroff; Bjoern Peters; Valerie Pasquetto; Magdalini Moutaftsi; John Sidney; Vijay Panchanathan; David C Tscharke; Bernard Maillere; Howard Grey; Alessandro Sette
Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7193-202.
2008: Erika Assarsson; Jason A Greenbaum; Magnus Sundström; Lana Schaffer; Jennifer A Hammond; Valerie Pasquetto; Carla Oseroff; R Curtis Hendrickson; Elliot J Lefkowitz; David C Tscharke; John Sidney; Howard Grey; Steven R Head; Bjoern Peters; Alessandro Sette
Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2140-5.
2007: Rebecca J Moor; Leanne E Morrison; Denis Moss; David C Tscharke
Use of CD107-based cell sorting ex vivo to enrich subdominant CD8+ T cells in culture.
Immunology and cell biology 2007;85(7):546-50.
2007: Matthew A Fischer; David C Tscharke; Keri B Donohue; Mary E Truckenmiller; Christopher C Norbury
Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming.
The Journal of general virology 2007;88(Pt 9):2378-86.
2006: David C Tscharke; Wai-Ping Woo; Isaac G Sakala; John Sidney; Alessandro Sette; Denis Moss; Jack R Bennink; Gunasegaran Karupiah; jon yewdell
Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice.
Journal of virology 2006;80(13):6318-23.
2006: Magdalini Moutaftsi; Bjoern Peters; Valerie Pasquetto; David C Tscharke; John Sidney; Huynh-Hoa Bui; Howard Grey; Alessandro Sette
A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus.
Nature biotechnology 2006;24(7):817-9.
2006: Richard H Clark; Julia C Kenyon; Nathan W Bartlett; David C Tscharke; Geoffrey L Smith
Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy.
The Journal of general virology 2006;87(Pt 1):29-38.
2005: Caroline L Smith; Mirza Fareed; Valerie Pasquetto; David C Tscharke; Michael J Palmowski; P Rod Dunbar; Alessandro Sette; Adrian L Harris; Vincenzo Cerundolo
Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia Ankara.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8431-7.
2005: Valerie Pasquetto; Huynh-Hoa Bui; Rielle Giannino; Cindy Banh; Mirza Fareed; John Sidney; Carla Oseroff; David C Tscharke; Kari Irvine; Jack R Bennink; Bjoern Peters; Scott Southwood; Vincenzo Cerundolo; Howard Grey; jon yewdell; Alessandro Sette
HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5504-15.
2005: Carla Oseroff; FERDYNAND KOS; Huynh-Hoa Bui; Bjoern Peters; Valerie Pasquetto; Jean Glenn; Tara Palmore; John Sidney; David C Tscharke; Jack R Bennink; Scott Southwood; Howard Grey; jon yewdell; Alessandro Sette
HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13980-5.
2005: S M Mansour Haeryfar; Richard DiPaolo; David C Tscharke; Jack R Bennink; jon yewdell
Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3344-51.
2005: David C Tscharke; Andreas Suhrbier
From mice to humans - murine intelligence for human CD8+ T cell vaccine design.
Expert opinion on biological therapy 2005;5(2):263-71.
2005: David C Tscharke; Gunasegaran Karupiah; Jie Zhou; Tara Palmore; Kari R Irvine; S M Mansour Haeryfar; Shanicka Williams; John Sidney; Alessandro Sette; Jack R Bennink; jon yewdell
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines.
The Journal of experimental medicine 2005;201(1):95-104.
2004: Christopher C Norbury; Sameh Basta; Keri B Donohue; David C Tscharke; Michael F Princiotta; Peter Berglund; James Gibbs; Jack R Bennink; jon yewdell
CD8+ T cell cross-priming via transfer of proteasome substrates.
Science (New York, N.Y.) 2004;304(5675):1318-21.
2003: Marta Pires de Miranda; Patrick Reading; David C Tscharke; Brendan Murphy; Geoffrey L Smith
The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal model.
The Journal of general virology 2003;84(Pt 9):2459-71.
2003: David C Tscharke; jon yewdell
T cells bite the hand that feeds them.
Nature medicine 2003;9(6):647-8.
2002: Julian A Symons; Elizabeth Adams; David C Tscharke; Patrick Reading; Herman Waldmann; Geoffrey L Smith
The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model.
The Journal of general virology 2002;83(Pt 11):2833-44.
2002: jon yewdell; David C Tscharke
Inside the professionals.
Nature 2002;418(6901):923-4.
2002: David C Tscharke; Patrick Reading; Geoffrey L Smith
Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routes.
The Journal of general virology 2002;83(Pt 8):1977-86.
2002: Nathan W Bartlett; Julian A Symons; David C Tscharke; Geoffrey L Smith
The vaccinia virus N1L protein is an intracellular homodimer that promotes virulence.
The Journal of general virology 2002;83(Pt 8):1965-76.
2002: Julian A Symons; David C Tscharke; Nicola Price; Geoffrey L Smith
A study of the vaccinia virus interferon-gamma receptor and its contribution to virus virulence.
The Journal of general virology 2002;83(Pt 8):1953-64.
2002: David C Tscharke; Geoffrey L Smith
Notes on transient host range selection for engineering vaccinia virus strain MVA.
BioTechniques 2002;33(1):186-8.
2002: Nicola Price; David C Tscharke; Geoffrey L Smith
The vaccinia virus B9R protein is a 6 kDa intracellular protein that is non-essential for virus replication and virulence.
The Journal of general virology 2002;83(Pt 4):873-8.
2001: A Ng; David C Tscharke; Patrick Reading; Geoffrey L Smith
The vaccinia virus A41L protein is a soluble 30 kDa glycoprotein that affects virus virulence.
The Journal of general virology 2001;82(Pt 9):2095-105.
2001: J D Gardner; David C Tscharke; Patrick Reading; Geoffrey L Smith
Vaccinia virus semaphorin A39R is a 50-55 kDa secreted glycoprotein that affects the outcome of infection in a murine intradermal model.
The Journal of general virology 2001;82(Pt 9):2083-93.
2001: F Almazán; David C Tscharke; Geoffrey L Smith
The vaccinia virus superoxide dismutase-like protein (A45R) is a virion component that is nonessential for virus replication.
Journal of virology 2001;75(15):7018-29.
2000: Nicola Price; David C Tscharke; Michael Hollinshead; Geoffrey L Smith
Vaccinia virus gene B7R encodes an 18-kDa protein that is resident in the endoplasmic reticulum and affects virus virulence.
Virology 2000;267(1):65-79.
1999: David C Tscharke; Geoffrey L Smith
A model for vaccinia virus pathogenesis and immunity based on intradermal injection of mouse ear pinnae.
The Journal of general virology 1999;80 ( Pt 10)():2751-5.