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Harald Tschesche

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Anneli Lauhio; Pekka Saikku; Tuula Salo; Harald Tschesche; Juhani Lähdevirta; Timo Sorsa
Combination treatment in Chlamydia-triggered reactive arthritis: comment on the article by Carter et al.
Matthias Kapischke; Tim Fischer; Katrin Tiessen; Harald Tschesche; Hans-Peter Bruch; Holger Kalthoff; Marie-Luise Kruse
Characterisation of a novel matrix metalloproteinase inhibitor on pancreatic adenocarcinoma cells in vitro and in an orthotopic pancreatic cancer model in vivo.
Frank J G M Kubben; Cornelis FM Sier; Lukas J A C Hawinkels; Harald Tschesche; Wim van Duijn; Kim Zuidwijk; Johan J van der Reijden; roeland hanemaaijer; Gerrit Griffioen; Cornelis B H W Lamers; Hein Verspaget
Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer.

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2011: Anneli Lauhio; Pekka Saikku; Tuula Salo; Harald Tschesche; Juhani Lähdevirta; Timo Sorsa
Combination treatment in Chlamydia-triggered reactive arthritis: comment on the article by Carter et al.
Arthritis and rheumatism 2011;63(1):305-7; author reply 307-8.
2008: Matthias Kapischke; Tim Fischer; Katrin Tiessen; Harald Tschesche; Hans-Peter Bruch; Holger Kalthoff; Marie-Luise Kruse
Characterisation of a novel matrix metalloproteinase inhibitor on pancreatic adenocarcinoma cells in vitro and in an orthotopic pancreatic cancer model in vivo.
International journal of oncology 2008;32(1):273-82.
2007: Frank J G M Kubben; Cornelis FM Sier; Lukas J A C Hawinkels; Harald Tschesche; Wim van Duijn; Kim Zuidwijk; Johan J van der Reijden; roeland hanemaaijer; Gerrit Griffioen; Cornelis B H W Lamers; Hein Verspaget
Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer.
European journal of cancer (Oxford, England : 1990) 2007;43(12):1869-76.
2007: Klaus Maskos; R Lang; Harald Tschesche; Wolfram Bode
Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2.
Journal of molecular biology 2007;366(4):1222-31.
2006: Giorgio Pochetti; Enrico Gavuzzo; Cristina Campestre; Mariangela Agamennone; Paolo Tortorella; Valerio Consalvi; Carlo Gallina; Oliver Hiller; Harald Tschesche; Paul Tucker; Fernando Mazza
Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
Journal of medicinal chemistry 2006;49(3):923-31.
2006: Cristina Campestre; Mariangela Agamennone; Paolo Tortorella; Serena Preziuso; Alessandro Biasone; Enrico Gavuzzo; Giorgio Pochetti; Fernando Mazza; Oliver Hiller; Harald Tschesche; Valerio Consalvi; Carlo Gallina
N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8.
Bioorganic & medicinal chemistry letters 2006;16(1):20-4.
2005: Veronika Beck; Hannes Herold; Anke Benge; Birgit Luber; Peter Hutzler; Harald Tschesche; Horst Kessler; Manfred Schmitt; Harald-Gerhard Geppert; Ute Reuning
ADAM15 decreases integrin alphavbeta3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion.
The international journal of biochemistry & cell biology 2005;37(3):590-603.
2004: Tiebang Kang; Harald Tschesche; Qing-Xiang Amy Sang
Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19.
Experimental cell research 2004;298(1):285-95.
2004: Peter Diehl; Bernd Hantke; Michael Hennig; Harald Tschesche; Wolfram Mittelmeier; Manfred Schmitt; Bernd Muehlenweg
Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis.
International journal of molecular medicine 2004;13(5):711-5.
2004: Wallid Naib-Majani; Isam Eltohami; Nicolas Wernert; William Watts; Harald Tschesche; Uwe Pleyer; Winrich Breipohl
Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2004;242(4):332-8.
2004: Douglas R Hurst; Martin A Schwartz; Mohammad A Ghaffari; Yonghao Jin; Harald Tschesche; Gregg Fields; Qing-Xiang Amy Sang
Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities.
The Biochemical journal 2004;377(Pt 3):775-9.
2003: Jörg Stute; Tayebeh Pourmotabbed; Harald Tschesche
Kinetic analysis of the binding of hemopexin-like domain of gelatinase B cloned and expressed in Pichia pastoris to tissue inhibitor of metalloproteinases-1.
Journal of protein chemistry 2003;22(6):509-14.
2003: Bernd Hantke; Nadia Harbeck; Barbara Schmalfeldt; Ingeborg Claes; Oliver Hiller; Marc-Oliver Luther; Anita Welk; Walther Kuhn; Manfred Schmitt; Harald Tschesche; Bernd Muehlenweg
Clinical relevance of matrix metalloproteinase-13 determined with a new highly specific and sensitive ELISA in ascitic fluid of advanced ovarian carcinoma patients.
Biological chemistry 2003;384(8):1247-51.
2003: Sabine Schmaldienst; André Oberpichler; Harald Tschesche; Walter H Hörl
Angiogenin: a novel inhibitor of neutrophil lactoferrin release during extracorporeal circulation.
Kidney & blood pressure research 2003;26(2):107-12.
2002: Subburaman Mohan; Garrett R Thompson; Yousef G Amaar; Gary Hathaway; Harald Tschesche; David J Baylink
ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts.
Biochemistry 2002;41(51):15394-403.
2002: Tiebang Kang; Hyun I Park; Yewseok Suh; Yun-Ge Zhao; Harald Tschesche; Qing-Xiang Amy Sang
Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity.
The Journal of biological chemistry 2002;277(50):48514-22.
2002: Bernd Hantke; Christine Lahmann; Kirsten Venzke; Tim Fischer; Andreas Kocourek; L Jack Windsor; Jörg Bergemann; Franz Stäb; Harald Tschesche
Influence of flavonoids and vitamins on the MMP- and TIMP-expression of human dermal fibroblasts after UVA irradiation.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2002;1(10):826-33.
2002: Magda Gioia; Giovanni Francesco Fasciglione; Stefano Marini; Silvana D'Alessio; Giampiero De Sanctis; Oliver Diekmann; Michael Pieper; Vincenzo Politi; Harald Tschesche; Massimo Coletta
Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain.
The Journal of biological chemistry 2002;277(26):23123-30.
2002: Kuljeet Kaur; Kijeen Zhu; Marilyn S Whittemore; Richard L Petersen; Andrea Lichte; Harald Tschesche; Tayebeh Pourmotabbed
Identification of the active site of gelatinase B as the structural element sufficient for converting a protein to a metalloprotease.
Biochemistry 2002;41(15):4789-97.
2002: Dirk Krumme; Harald Tschesche
Oxal hydroxamic acid derivatives with inhibitory activity against matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 2002;12(6):933-6.
2002: Massimiliano Aschi; Danilo Roccatano; Alfredo Di Nola; Carlo Gallina; Enrico Gavuzzo; Giorgio Pochetti; Michael Pieper; Harald Tschesche; Fernando Mazza
Computational study of the catalytic domain of human neutrophil collagenase. specific role of the S3 and S'3 subsites in the interaction with a phosphonate inhibitor.
Journal of computer-aided molecular design 2002;16(3):213-25.
2001: J Schnepel; J Unger; Harald Tschesche
Recombinant cryptic human fibronectinase cleaves actin and myosin: substrate specificity and possible role in muscular dystrophy.
Biological chemistry 2001;382(12):1707-14.
2001: B Stratmann; M Farr; Harald Tschesche
MMP-TIMP interaction depends on residue 2 in TIMP-4.
FEBS letters 2001;507(3):285-7.
2001: R Lang; Andreas Kocourek; M Braun; Harald Tschesche; Robert Huber; Wolfram Bode; Klaus Maskos
Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.
Journal of molecular biology 2001;312(4):731-42.
2001: J Schröder; A Henke; HR Wenzel; H Brandstetter; Hans-Georg Stammler; Anja Stammler; W D Pfeiffer; Harald Tschesche
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
Journal of medicinal chemistry 2001;44(20):3231-43.
2001: B Stratmann; M Farr; Harald Tschesche
Characterization of C-terminally truncated human tissue inhibitor of metalloproteinases-4 expressed in Pichia pastoris.
Biological chemistry 2001;382(6):987-91.
2001: J Schröder; HR Wenzel; Hans-Georg Stammler; Anja Stammler; Beate Neumann; Harald Tschesche
Novel heterocyclic inhibitors of matrix metalloproteinases: three 6H-1,3,4-thiadiazines.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 5):593-6.
2001: Harald Tschesche; V Zölzer; S Triebel; S Bartsch
The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases.
European journal of biochemistry / FEBS 2001;268(7):1918-28.
2001: L Schwettmann; Harald Tschesche
Cloning and expression in Pichia pastoris of metalloprotease domain of ADAM 9 catalytically active against fibronectin.
Protein expression and purification 2001;21(1):65-70.
2000: J Schnepel; Harald Tschesche
The proteolytic activity of the recombinant cryptic human fibronectin type IV collagenase from E. coli expression.
Journal of protein chemistry 2000;19(8):685-92.
2000: Oliver Hiller; Andrea Lichte; André Oberpichler; Andreas Kocourek; Harald Tschesche
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII.
The Journal of biological chemistry 2000;275(42):33008-13.
2000: M Farr; J Strübe; Harald-Gerhard Geppert; Andreas Kocourek; M Mahne; Harald Tschesche
Pregnancy-associated plasma protein-E (PAPP-E).
Biochimica et biophysica acta 2000;1493(3):356-62.
2000: Enrico Gavuzzo; Giorgio Pochetti; Fernando Mazza; Carlo Gallina; B Gorini; Silvana D'Alessio; Michael Pieper; Harald Tschesche; Paul Tucker
Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design.
Journal of medicinal chemistry 2000;43(18):3377-85.
2000: M Roderfeld; Frank H Büttner; Eckart Bartnik; Harald Tschesche
Expression of human membrane type 1 matrix metalloproteinase in Pichia pastoris.
Protein expression and purification 2000;19(3):369-74.
2000: K Eberle; André Oberpichler; Christos Trantakis; Wolfgang Krupp; Matthias Knüpfer; Harald Tschesche; Volker Seifert
The expression of angiogenin in tissue samples of different brain tumours and cultured glioma cells.
Anticancer research 2000;20(3A):1679-84.
2000: J Ottl; D Gabriel; G Murphy; Vera Knäuper; Y Tominaga; Hideaki Nagase; M Kröger; Harald Tschesche; Wolfram Bode; Luis Moroder
Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases.
Chemistry & biology 2000;7(2):119-32.
2000: Harald Tschesche; Andrea Lichte; Oliver Hiller; André Oberpichler; Frank H Büttner; Eckart Bartnik
Matrix metalloproteinases (MMP-8, -13, and -14) interact with the clotting system and degrade fibrinogen and factor XII (Hagemann factor).
Advances in experimental medicine and biology 2000;477():217-28.
1999: Matthias Winkler; André Oberpichler; Harald Tschesche; Peter Ruck; Dagmar-C Fischer; Werner Rath
Collagenolysis in the lower uterine segment during parturition at term: correlations with stage of cervical dilatation and duration of labor.
American journal of obstetrics and gynecology 1999;181(1):153-8.
1999: Wolfram Bode; Carlos Fernandez-Catalan; Frank Grams; FX Gomis-Rüth; Hideaki Nagase; Harald Tschesche; Klaus Maskos
Insights into MMP-TIMP interactions.
Annals of the New York Academy of Sciences 1999;878():73-91.
1999: M Farr; Michael Pieper; J Calvete; Harald Tschesche
The N-terminus of collagenase MMP-8 determines superactivity and inhibition: a relation of structure and function analyzed by biomolecular interaction analysis.
Biochemistry 1999;38(22):7332-8.
1999: Murray Coles; Tammo Diercks; Bernd Muehlenweg; S Bartsch; V Zölzer; Harald Tschesche; Horst Kessler
The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin.
Journal of molecular biology 1999;289(1):139-57.
1999: J Unger; Harald Tschesche
The proteolytic activity and cleavage specificity of fibronectin-gelatinase and fibronectin-lamininase.
Journal of protein chemistry 1999;18(4):403-11.
1999: Wolfram Bode; Carlos Fernandez-Catalan; Harald Tschesche; Frank Grams; Hideaki Nagase; Klaus Maskos
Structural properties of matrix metalloproteinases.
Cellular and molecular life sciences : CMLS 1999;55(4):639-52.
1999: Matthias Winkler; Dagmar-C Fischer; Peter Ruck; T Marx; E Kaiserling; André Oberpichler; Harald Tschesche; Werner Rath
Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment.
Human reproduction (Oxford, England) 1999;14(4):1096-100.
1998: D Krumme; HR Wenzel; Harald Tschesche
Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases.
FEBS letters 1998;436(2):209-12.
1998: Carlos Fernandez-Catalan; Wolfram Bode; Robert Huber; Dusan Turk; J J Calvete; Andrea Lichte; Harald Tschesche; Klaus Maskos
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
The EMBO journal 1998;17(17):5238-48.
1998: Harald Tschesche
Bimolecular interaction of matrix metalloproteinases and their inhibitors TIMPs.
Journal of protein chemistry 1998;17(6):549-51.
1998: Frank H Büttner; Clare E Hughes; D Margerie; Andrea Lichte; Harald Tschesche; Bruce Caterson; Eckart Bartnik
Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
The Biochemical journal 1998;333 ( Pt 1)():159-65.
1998: H Li; D E Bauzon; X Xu; Harald Tschesche; Jian Cao; Q A Sang
Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts.
Molecular carcinogenesis 1998;22(2):84-94.
1997: M Kröger; Harald Tschesche
Cloning, expression and activation of a truncated 92-kDa gelatinase minienzyme.
Gene 1997;196(1-2):175-80.
1997: Michael Pieper; M Betz; N Budisa; F X Gomis-Rüth; W Bode; Harald Tschesche
Expression, purification, characterization, and X-ray analysis of selenomethionine 215 variant of leukocyte collagenase.
Journal of protein chemistry 1997;16(6):637-50.
1997: M Betz; P Huxley; S J Davies; Y Mushtaq; Michael Pieper; Harald Tschesche; Wolfram Bode; FX Gomis-Rüth
1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile.
European journal of biochemistry / FEBS 1997;247(1):356-63.
1997: R Clark Billinghurst; Leif Dahlberg; Mirela Ionescu; Agnes Reiner; Robert Bourne; C Rorabeck; P Mitchell; J Hambor; O Diekmann; Harald Tschesche; Jeffrey Chen; Harold E Van Wart; A Robin Poole
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.
The Journal of clinical investigation 1997;99(7):1534-45.
1997: Vera Knäuper; Andrew J P Docherty; B Smith; Harald Tschesche; Gillian Murphy
Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis.
FEBS letters 1997;405(1):60-4.
1997: Harald Tschesche
Leukodiapedesis, function, and physiological role of leucocyte matrix metalloproteinases.
Advances in experimental medicine and biology 1997;421():285-301.
1996: J Ottl; R Battistuta; Michael Pieper; Harald Tschesche; Wolfram Bode; K Kühn; Luis Moroder
Design and synthesis of heterotrimeric collagen peptides with a built-in cystine-knot. Models for collagen catabolism by matrix-metalloproteases.
FEBS letters 1996;398(1):31-6.
1996: A Lichte; H Kolkenbrock; Harald Tschesche
The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2.
FEBS letters 1996;397(2-3):277-82.
1996: Johannes Müthing; R Spanbroek; J Peter-Katalinić; F G Hanisch; C Hanski; A Hasegawa; F Unland; Jürgen Lehmann; Harald Tschesche; H Egge
Isolation and structural characterization of fucosylated gangliosides with linear poly-N-acetyllactosaminyl chains from human granulocytes.
Glycobiology 1996;6(2):147-56.
1996: J Blaser; S Triebel; U Maasjosthusmann; J Romisch; U Krahl-Mateblowski; W Freudenberg; R Fricke; Harald Tschesche
Determination of metalloproteinases, plasminogen-activators and their inhibitors in the synovial fluids of patients with rheumatoid arthritis during chemical synoviorthesis.
Clinica chimica acta; international journal of clinical chemistry 1996;244(1):17-33.
1996: V Knäuper; G Murphy; Harald Tschesche
Activation of human neutrophil procollagenase by stromelysin 2.
European journal of biochemistry / FEBS 1996;235(1-2):187-91.
1995: P Kurschat; Lutz Graeve; A Erren; P Gatsios; Stefan Rose-John; Elke Roeb; Harald Tschesche; Aleksander Koj; Peter C Heinrich
Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Purification and tissue distribution in the rat.
European journal of biochemistry / FEBS 1995;234(2):485-91.
1995: Frank Grams; M Crimmin; L Hinnes; P Huxley; Michael Pieper; Harald Tschesche; Wolfram Bode
Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor.
Biochemistry 1995;34(43):14012-20.
1995: N Balke; U Holtkamp; W H Hörl; Harald Tschesche
Inhibition of degranulation of human polymorphonuclear leukocytes by complement factor D.
FEBS letters 1995;371(3):300-2.
1995: S Triebel; J Bläser; T Gote; G Pelz; E Schüren; Manfred Schmitt; Harald Tschesche
Evidence for the tissue inhibitor of metalloproteinases-1 (TIMP-1) in human polymorphonuclear leukocytes.
European journal of biochemistry / FEBS 1995;231(3):714-9.
1995: Rüdiger Osmers; J Bläser; Walther Kuhn; Harald Tschesche
Interleukin-8 synthesis and the onset of labor.
Obstetrics and gynecology 1995;86(2):223-9.
1995: Rüdiger Osmers; B C Adelmann-Grill; Werner Rath; H W Stuhlsatz; Harald Tschesche; Walther Kuhn
Biochemical events in cervical ripening dilatation during pregnancy and parturition.
Journal of obstetrics and gynaecology (Tokyo, Japan) 1995;21(2):185-94.
1995: J Bläser; S Triebel; Harald Tschesche
A sandwich enzyme immunoassay for the determination of neutrophil lipocalin in body fluids.
Clinica chimica acta; international journal of clinical chemistry 1995;235(2):137-45.
1995: Frank Grams; Peter Reinemer; James C Powers; T Kleine; Michael Pieper; Harald Tschesche; Robert Huber; Wolfram Bode
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
European journal of biochemistry / FEBS 1995;228(3):830-41.
1995: S Bartsch; Harald Tschesche
Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells.
FEBS letters 1995;357(3):255-9.
1995: Harald Tschesche
Human neutrophil collagenase.
Methods in enzymology 1995;248():431-49.
1994: Harald Tschesche; C Kopp; W H Hörl; U Hempelmann
Inhibition of degranulation of polymorphonuclear leukocytes by angiogenin and its tryptic fragment.
The Journal of biological chemistry 1994;269(48):30274-80.
1994: Harald Tschesche; J Bläser; T Kleine; S Schnierer; Peter Reinemer; Wolfram Bode; U Maasjoshusmann; C Fricke
Inhibition of matrix metalloproteinases in rheumatoid arthritis and the crystallographic binding mode of a peptide inhibitor.
Annals of the New York Academy of Sciences 1994;732():400-2.
1994: O Diekmann; Harald Tschesche
Degradation of kinins, angiotensins and substance P by polymorphonuclear matrix metalloproteinases MMP 8 and MMP 9.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(8):1865-76.
1994: C Groeger; H R Wenzel; Harald Tschesche
BPTI backbone variants and implications for inhibitory activity.
International journal of peptide and protein research 1994;44(2):166-72.
1994: Wolfram Bode; Peter Reinemer; Robert Huber; T Kleine; S Schnierer; Harald Tschesche
The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.
The EMBO journal 1994;13(6):1263-9.
1994: M Günther; HD Haubeck; E van de Leur; J Bläser; S Bender; I Gütgemann; Dagmar-C Fischer; Harald Tschesche; H Greiling; Peter C Heinrich
Transforming growth factor beta 1 regulates tissue inhibitor of metalloproteinases-1 expression in differentiated human articular chondrocytes.
Arthritis and rheumatism 1994;37(3):395-405.
1994: Peter Reinemer; Frank Grams; Robert Huber; T Kleine; S Schnierer; M Piper; Harald Tschesche; Wolfram Bode
Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.
FEBS letters 1994;338(2):227-33.
1994: Rüdiger Osmers; Harald Tschesche; Werner Rath; M Szeverényi; V Süwer; I Wölker; Walther Kuhn
Serum collagenase levels during pregnancy and parturition.
European journal of obstetrics, gynecology, and reproductive biology 1994;53(1):55-7.
1993: T Kleine; S Bartsch; J Bläser; S Schnierer; S Triebel; M Valentin; T Gote; Harald Tschesche
Preparation of active recombinant TIMP-1 from Escherichia coli inclusion bodies and complex formation with the recombinant catalytic domain of PMNL-collagenase.
Biochemistry 1993;32(51):14125-31.
1993: V Knäuper; S M Wilhelm; P K Seperack; Yves A DeClerck; KE Langley; A Osthues; Harald Tschesche
Direct activation of human neutrophil procollagenase by recombinant stromelysin.
The Biochemical journal 1993;295 ( Pt 2)():581-6.
1993: G Pelz; A Schettler; Harald Tschesche
Granulocyte chemotaxis measured in a Boyden chamber assay by quantification of neutrophil elastase.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1993;31(10):651-6.
1993: J Bläser; S Triebel; C Kopp; Harald Tschesche
A highly sensitive immunoenzymometric assay for the determination of angiogenin.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1993;31(8):513-6.
1993: V Knäuper; A Osthues; Yves A DeClerck; KE Langley; J Bläser; Harald Tschesche
Fragmentation of human polymorphonuclear-leucocyte collagenase.
The Biochemical journal 1993;291 ( Pt 3)():847-54.
1993: S Schnierer; T Kleine; T Gote; A Hillemann; V Knäuper; Harald Tschesche
The recombinant catalytic domain of human neutrophil collagenase lacks type I collagen substrate specificity.
Biochemical and biophysical research communications 1993;191(2):319-26.
1993: Johannes Müthing; F Unland; D Heitmann; M Orlich; F G Hanisch; J Peter-Katalinić; V Knäuper; Harald Tschesche; S Kelm; R Schauer
Different binding capacities of influenza A and Sendai viruses to gangliosides from human granulocytes.
Glycoconjugate journal 1993;10(1):120-6.
1992: S Triebel; J Bläser; H Reinke; Harald Tschesche
A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase.
FEBS letters 1992;314(3):386-8.
1992: Tomasz Kordula; I Güttgemann; Stefan Rose-John; Elke Roeb; A Osthues; Harald Tschesche; Aleksander Koj; Peter C Heinrich; Lutz Graeve
Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1.
FEBS letters 1992;313(2):143-7.
1992: J Bläser; S Triebel; H Reinke; Harald Tschesche
Formation of a covalent Hg-Cys-bond during mercurial activation of PMNL procollagenase gives evidence of a cysteine-switch mechanism.
FEBS letters 1992;313(1):59-61.
1992: B Bakowski; Harald Tschesche
Migration of polymorphonuclear leukocytes through human amnion membrane--a scanning electron microscopic study.
Biological chemistry Hoppe-Seyler 1992;373(7):529-46.
1992: Rüdiger Osmers; Werner Rath; B C Adelmann-Grill; C Fittkow; M Kuloczik; M Szeverényi; Harald Tschesche; Walther Kuhn
Origin of cervical collagenase during parturition.
American journal of obstetrics and gynecology 1992;166(5):1455-60.
1992: S Triebel; J Bläser; H Reinke; V Knäuper; Harald Tschesche
Mercurial activation of human PMN leucocyte type IV procollagenase (gelatinase).
FEBS letters 1992;298(2-3):280-4.
1992: A Osthues; V Knäuper; R Oberhoff; H Reinke; Harald Tschesche
Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid.
FEBS letters 1992;296(1):16-20.
1992: Harald Tschesche; V Knäuper; S Krämer; J Michaelis; R Oberhoff; H Reinke
Latent collagenase and gelatinase from human neutrophils and their activation.
Matrix (Stuttgart, Germany). Supplement 1992;1():245-55.
1991: J Bläser; V Knäuper; A Osthues; H Reinke; Harald Tschesche
Mercurial activation of human polymorphonuclear leucocyte procollagenase.
European journal of biochemistry / FEBS 1991;202(3):1223-30.
1991: Thomas BRINKMANN; S Schnierer; Harald Tschesche
Recombinant aprotinin homologue with new inhibitory specificity for cathepsin G.
European journal of biochemistry / FEBS 1991;202(1):95-9.
1991: C Groeger; H R Wenzel; Harald Tschesche
Chemical semisynthesis of aprotinin homologues and derivatives mutated in P' positions.
Journal of protein chemistry 1991;10(5):527-33.
1991: V Knäuper; S Triebel; H Reinke; Harald Tschesche
Inactivation of human plasma C1-inhibitor by human PMN leucocyte matrix metalloproteinases.
FEBS letters 1991;290(1-2):99-102.
1991: A Schettler; H Thorn; Brigitte M Jockusch; Harald Tschesche
Release of proteinases from stimulated polymorphonuclear leukocytes. Evidence for subclasses of the main granule types and their association with cytoskeletal components.
European journal of biochemistry / FEBS 1991;197(1):197-202.
1991: C Groeger; H R Wenzel; Harald Tschesche
Enzymatic semisynthesis of aprotinin homologues mutated in P' positions.
Journal of protein chemistry 1991;10(2):245-51.
1991: U Hempelmann; M Haag-Weber; W H Hörl; Harald Tschesche
Effect of immunosuppressive drugs on the release of metalloproteinases from human polymorphonuclear leukocytes.
Transplant international : official journal of the European Society for Organ Transplantation 1991;4(1):26-30.
1991: Harald Tschesche; C Groeger; H R Wenzel
Enzymatic fragment substitution as a tool in protein design.
Biomedica biochimica acta 1991;50(10-11):S175-80.
1991: Harald Tschesche; B Bakowski; A Schettler; V Knäuper; H Reinke
Leukodiapedesis, release of PMN leukocyte proteinases and activation of PMNL procollagenase.
Biomedica biochimica acta 1991;50(4-6):755-61.
1991: Harald Tschesche; B Bakowski; A Schettler; V Knäuper; H Reinke; S Krämer
Leukodiapedesis, compartmentalisation and secretion of PMN leukocyte proteinases, and activation of PMN leukocyte procollagenase.
Advances in experimental medicine and biology 1991;297():39-53.
1990: Werner Rath; Rüdiger Osmers; B C Adelmann-Grill; H W Stuhlsatz; Harald Tschesche; M Szevérini
[Principles of physiologic and drug-induced cervix ripening--recent morphologic and biochemical findings].
Geburtshilfe und Frauenheilkunde 1990;50(9):657-64.
1990: H R Wenzel; A Feldmann; S Engelbrecht; Harald Tschesche
Activation of the human leukocyte proteinases elastase and cathepsin G by various surfactants.
Biological chemistry Hoppe-Seyler 1990;371(8):721-4.
1990: V Knäuper; S Krämer; H Reinke; Harald Tschesche
Partial amino-acid sequence of human PMN leukocyte procollagenase.
Biological chemistry Hoppe-Seyler 1990;371(8):733.
1990: M Nitsch; D Gabrijelcic; Harald Tschesche
Separation of granule subpopulations in human polymorphonuclear leukocytes.
Biological chemistry Hoppe-Seyler 1990;371(7):611-5.
1990: V Knäuper; S Krämer; H Reinke; Harald Tschesche
Partial amino acid sequence of human PMN leukocyte procollagenase.
Biological chemistry Hoppe-Seyler 1990;371 Suppl():295-304.
1990: Thomas BRINKMANN; Harald Tschesche
Design of an aprotinin variant with inhibitory activity against chymotrypsin and cathepsin G by recombinant DNA technology.
Biological chemistry Hoppe-Seyler 1990;371 Suppl():43-52.
1990: V Knäuper; S Krämer; H Reinke; Harald Tschesche
Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms.
European journal of biochemistry / FEBS 1990;189(2):295-300.
1990: V Knäuper; H Reinke; Harald Tschesche
Inactivation of human plasma alpha 1-proteinase inhibitor by human PMN leucocyte collagenase.
FEBS letters 1990;263(2):355-7.
1989: A Mehlich; J Beckmann; H R Wenzel; Harald Tschesche
Semisynthetic aprotinin derivatives with specific alterations at the reactive-site peptide bond can be used to study structure-function relationships.
Biochimica et biophysica acta 1989;996(1-2):23-9.
1989: U Bergmann; J Michaelis; R Oberhoff; V Knäuper; R Beckmann; Harald Tschesche
Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie 1989;27(6):351-9.
1989: J Beckmann; A Mehlich; W Schröder; H R Wenzel; Harald Tschesche
Semisynthesis of Arg15, Glu15, Met15, and Nle15-aprotinin involving enzymatic peptide bond resynthesis.
Journal of protein chemistry 1989;8(1):101-13.
1989: Harald Tschesche; J Michaelis; U Kohnert; J Fedrowitz; R Oberhoff
Tissue kallikrein effectively activates latent matrix degrading metalloenzymes.
Advances in experimental medicine and biology 1989;247A():545-8.
1989: Harald Tschesche; J Beckmann; A Mehlich; A Feldmann; H R Wenzel; C F Scott; R W Colman
Semisynthetic arginine-15-aprotinin, an improved inhibitor for human plasma kallikrein.
Advances in experimental medicine and biology 1989;247B():15-21.
1988: A Mehlich; J Beckmann; H R Wenzel; Harald Tschesche
Aprotinin derivatives with chromophoric leaving groups can be used as highly selective active-site titrants for serine proteinases and permit the determination of kinetic constants of enzyme-inhibitor complexes.
Biochimica et biophysica acta 1988;957(3):420-9.
1988: J Siekmann; H R Wenzel; E Matuszak; E von Goldammer; Harald Tschesche
The pH dependence of the equilibrium constant KHyd for the hydrolysis of the Lys15-Ala16 reactive-site peptide bond in bovine pancreatic trypsin inhibitor (aprotinin).
Journal of protein chemistry 1988;7(5):633-40.
1988: J Beckmann; A Mehlich; W Schröder; H R Wenzel; Harald Tschesche
Preparation of chemically 'mutated' aprotinin homologues by semisynthesis. P1 substitutions change inhibitory specificity.
European journal of biochemistry / FEBS 1988;176(3):675-82.
1988: U C von Clausbruch; Harald Tschesche
Cathepsin D from human leukocytes. Purification by affinity chromatography and properties of the enzyme.
Biological chemistry Hoppe-Seyler 1988;369(8):683-91.
1988: E Schnabel; G Reinhardt; W Schröder; Harald Tschesche; H R Wenzel; A Mehlich
Enzymatic resynthesis of the "reactive site" bond in the modified aprotinin derivatives [seco-15/16]aprotinin and [Di-seco-15/16,39/40]aprotinin.
Biological chemistry Hoppe-Seyler 1988;369(6):461-8.
1988: J Siekmann; H R Wenzel; W Schröder; Harald Tschesche
Characterization and sequence determination of six aprotinin homologues from bovine lungs.
Biological chemistry Hoppe-Seyler 1988;369(3):157-63.
1988: J Beckmann; A Mehlich; H R Wenzel; Harald Tschesche
Semisynthetic inhibitors of human leukocyte elastase and their protective effect on lung elastin degradation in vitro.
Advances in experimental medicine and biology 1988;240():107-14.
1988: U Kohnert; R Oberhoff; J Fedrowitz; U Bergmann; J Rauterberg; Harald Tschesche
The degradation of collagen by a metalloproteinase from human leucocytes.
Advances in experimental medicine and biology 1988;240():33-44.
1987: J Siekmann; H R Wenzel; W Schröder; H Schutt; E Truscheit; A Arens; E Rauenbusch; W J Chazin; K Wüthrich; Harald Tschesche
Pyroglutamyl-aprotinin, a new aprotinin homologue from bovine lungs--isolation, properties, sequence analysis and characterization using 1H nuclear magnetic resonance in solution.
Biological chemistry Hoppe-Seyler 1987;368(12):1589-96.
1987: Harald Tschesche; H Kolkenbrock; Wolfram Bode
The covalent structure of the elastase inhibitor from Anemonia sulcata--a "non-classical" Kazal-type protein.
Biological chemistry Hoppe-Seyler 1987;368(10):1297-304.
1987: H Schwarz; Hans-Jürgen Hinz; A Mehlich; Harald Tschesche; H R Wenzel
Stability studies on derivatives of the bovine pancreatic trypsin inhibitor.
Biochemistry 1987;26(12):3544-51.
1987: Harald Tschesche; J Beckmann; A Mehlich; E Schnabel; E Truscheit; H R Wenzel
Semisynthetic engineering of proteinase inhibitor homologues.
Biochimica et biophysica acta 1987;913(1):97-101.
1986: Harald Tschesche; J Fedrowitz; U Kohnert; J Michaelis; H W Macartney
Matrix degrading proteinases from human granulocytes: type I, II, III collagenase, gelatinase and type IV, V-collagenase. A survey of recent findings and inhibition by gamma-anticollagenase.
Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 1986;24(2):125-31.
1982: H R Wenzel; Harald Tschesche; E von Goldammer; U Netzelmann
Complex formation of guanidinated bovine trypsin inhibitor (Kunitz) with trypsin, chymotrypsin and trypsinogen as studied by the spin-label technique.
FEBS letters 1982;140(1):53-7.
1982: S Engelbrecht; E Pieper; H W Macartney; W Rautenberg; H R Wenzel; Harald Tschesche
Separation of the human leucocyte enzymes alanine aminopeptidase, cathepsin G, collagenase, elastase and myeloperoxidase.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1982;363(3):305-15.
1980: H R Wenzel; S Engelbrecht; H Reich; W Mondry; Harald Tschesche
Synthesis and analytical use of 3-carboxypropionyl-alanyl-alanyl-valine-4-nitroanilide: a specific substrate for human leukocyte elastase.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1980;361(9):1413-6.