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Carsten Tschöpe

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Ventricular Function, Left

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Frank Edelmann; Götz Gelbrich; Martin Halle; Gerd Hasenfuss; Christoph Herrmann-Lingen; Wolfram Kamke; Elisabeth Kraigher-Krainer; Markus Loeffler; Burkert Pieske; Albrecht G Schmidt; Raoul Stahrenberg; Carsten Tschöpe; Rolf Wachter; Caterina Colantonio; Hans-Dirk Düngen; Kathleen Durstewitz; André Duvinage
Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial.
Mario Kasner; Wolfgang Poller; Heinz-Peter Schultheiss; Paul Steendijk; Stephan Dröse; Dirk Westermann; Carsten Tschöpe
Left ventricular dysfunction induced by nonsevere idiopathic pulmonary arterial hypertension: a pressure-volume relationship study.
Peter Moritz Becher; Diana Lindner; Kapka Miteva; Konstantinos Savvatis; Bastian Schmack; Heinz-Peter Schultheiss; Sophie Van Linthout; Dirk Westermann; Christin Zietsch; Carsten Tschöpe
Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade.

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2013: Frank Edelmann; Götz Gelbrich; Martin Halle; Gerd Hasenfuss; Christoph Herrmann-Lingen; Wolfram Kamke; Elisabeth Kraigher-Krainer; Markus Loeffler; Burkert Pieske; Albrecht G Schmidt; Raoul Stahrenberg; Carsten Tschöpe; Rolf Wachter; Caterina Colantonio; Hans-Dirk Düngen; Kathleen Durstewitz; André Duvinage
Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial.
JAMA : the journal of the American Medical Association 2013;309(8):781-91.
2012: Mario Kasner; Wolfgang Poller; Heinz-Peter Schultheiss; Paul Steendijk; Stephan Dröse; Dirk Westermann; Carsten Tschöpe
Left ventricular dysfunction induced by nonsevere idiopathic pulmonary arterial hypertension: a pressure-volume relationship study.
American journal of respiratory and critical care medicine 2012;186(2):181-9.
2012: Peter Moritz Becher; Diana Lindner; Kapka Miteva; Konstantinos Savvatis; Bastian Schmack; Heinz-Peter Schultheiss; Sophie Van Linthout; Dirk Westermann; Christin Zietsch; Carsten Tschöpe
Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade.
Hypertension 2012;59(5):949-57.
2012: Konstantinos Savvatis; Joerg Schefold; Heinz-Peter Schultheiss; Sophie Van Linthout; Alice Weithäuser; Dirk Westermann; Peter-Moritz Becher; Gerhard Fusch; Karin Klingel; Andreas Kurtz; Kapka Miteva; Kathleen Pappritz; Ursula Rauch; Jochen Ringe; Carsten Tschöpe
Mesenchymal stromal cells but not cardiac fibroblasts exert beneficial systemic immunomodulatory effects in experimental myocarditis.
PloS one 2012;7(7):e41047.
2012: Diana Lindner; Katharina Marggraf; Matthias Pauschinger; Heinz-Peter Schultheiss; Carsten Tschöpe; P Moritz Becher; Moritz Hilbrandt; Denise Hilfiker-Kleiner; Karin Klingel; Dirk Westermann
Protective Function of STAT3 in CVB3-Induced Myocarditis.
Cardiology research and practice 2012;2012():437623.
2012: Diana Lindner; Heinz-Peter Schultheiss; Karsten Schulze; Carsten Tschöpe; P Moritz Becher; Christin Zietsch; Dirk Westermann
Differential expression of matrix metalloproteases in human fibroblasts with different origins.
Biochemistry research international 2012;2012():875742.
2011: Dirk Westermann; Christin Zietsch; Uwe Völker; Peter Moritz Becher; Stefan Bereswill; Felicitas Escher; Elke Hammer; Markus M Heimesaat; Karin Klingel; Diana Lindner; Johanna Plendl; Wolfgang Poller; Alexander Riad; Kostantinos Savvatis; Heinz-Peter Schultheiss; Carsten Tschöpe
Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy.
Circulation 2011;124(19):2082-93.
2011: Thomas Budde; Stephan B Felix; Sandra Bien; Jeanette Haney; Gabriele Jedlitschky; Heyo K Kroemer; Alexander Riad; Matthias Schwebe; Alexander Staudt; Carsten Tschöpe; Markus Grube
Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression.
Journal of pharmaceutical sciences 2011;100(9):3951-8.
2011: Sophie Van Linthout; K Warstat; K Miteva; J Peng; J Ringe; K Savvatis; Caroline Schmidt-Lucke; Heinz-Peter Schultheiss; M Sittinger; Carsten Tschöpe
Mesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis.
European heart journal 2011;32(17):2168-78.
2011: Mario Kasner; Regina Gaub; Dirk Westermann; Hilmi Kaplan; Susan Akpulat; Paul Steendijk; Heinz-Peter Schultheiss; Carsten Tschöpe
Simultaneous estimation of NT-proBNP on top to mitral flow Doppler echocardiography as an accurate strategy to diagnose diastolic dysfunction in HFNEF.
International journal of cardiology 2011;149(1):23-9.
2011: Felicitas Escher; Roland Vetter; Uwe Kühl; Dirk Westermann; Heinz-Peter Schultheiss; Carsten Tschöpe
Fractalkine in human inflammatory cardiomyopathy.
Heart (British Cardiac Society) 2011;97(9):733-9.
2011: Felicitas Escher; Dirk Westermann; Regina Gaub; Johannes Pronk; Thomas Bock; Nidal al-Saadi; Uwe Kühl; Heinz-Peter Schultheiss; Carsten Tschöpe
Development of diastolic heart failure in a 6-year follow-up study in patients after acute myocarditis.
Heart (British Cardiac Society) 2011;97(9):709-14.
2011: Mario Kasner; Dirk Westermann; Begoña Lopez; Regina Gaub; Felicitas Escher; Uwe Kühl; Heinz-Peter Schultheiss; Carsten Tschöpe
Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction.
Journal of the American College of Cardiology 2011;57(8):977-85.
2011: Alexander Riad; Dirk Westermann; Christin Zietsch; Konstantinos Savvatis; Peter M Becher; Stefan Bereswill; Markus M Heimesaat; Olga Lettau; Dirk Lassner; Andrea Dörner; Wolfgang Poller; Mathias Busch; Stephan B Felix; Heinz P Schultheiss; Carsten Tschöpe
TRIF is a critical survival factor in viral cardiomyopathy.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2561-70.
2011: Sophie Van Linthout; Frank Spillmann; Gallia Graiani; Kapka Miteva; Jun Peng; Eline Van Craeyveld; Marco Meloni; Markus Tölle; Felicitas Escher; Aysun Subasigüller; Wolfram Doehner; Federico Quaini; Bart De Geest; Heinz-Peter Schultheiss; Carsten Tschöpe
Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation.
Journal of molecular medicine (Berlin, Germany) 2011;89(2):151-60.
2011: David Sinning; Mario Kasner; Dirk Westermann; Karsten Schulze; Heinz-Peter Schultheiss; Carsten Tschöpe
Increased left ventricular stiffness impairs exercise capacity in patients with heart failure symptoms despite normal left ventricular ejection fraction.
Cardiology research and practice 2011;2011():692862.
2011: Sophie Van Linthout; Ch Stamm; Heinz-Peter Schultheiss; Carsten Tschöpe
Mesenchymal stem cells and inflammatory cardiomyopathy: cardiac homing and beyond.
Cardiology research and practice 2011;2011():757154.
2011: Dirk Westermann; Diana Lindner; Mario Kasner; Christine Zietsch; K Savvatis; Felicitas Escher; J von Schlippenbach; C Skurk; Paul Steendijk; Alexander Riad; Wolfgang Poller; Heinz-Peter Schultheiss; Carsten Tschöpe
Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction.
Circulation. Heart failure 2011;4(1):44-52.
2010: Mario Kasner; Regina Gaub; David Sinning; Dirk Westermann; Paul Steendijk; Wolfgang Hoffmann; Heinz-Peter Schultheiss; Carsten Tschöpe
Global strain rate imaging for the estimation of diastolic function in HFNEF compared with pressure-volume loop analysis.
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 2010;11(9):743-51.
2010: Alexander Riad; Dirk Westermann; Felicitas Escher; Peter M Becher; Konstantinos Savvatis; Olga Lettau; Markus M Heimesaat; Stefan Bereswill; Hans D Volk; Heinz P Schultheiss; Carsten Tschöpe
Myeloid differentiation factor-88 contributes to TLR9-mediated modulation of acute coxsackievirus B3-induced myocarditis in vivo.
American journal of physiology. Heart and circulatory physiology 2010;298(6):H2024-31.
2010: Sophie Van Linthout; Anna Foryst-Ludwig; Frank Spillmann; Jun Peng; Yingmei Feng; Marco Meloni; Eline Van Craeyveld; Ulrich Kintscher; Heinz-Peter Schultheiss; Bart De Geest; Carsten Tschöpe
Impact of HDL on adipose tissue metabolism and adiponectin expression.
Atherosclerosis 2010;210(2):438-44.
2010: Sophie Van Linthout; Frank Spillmann; Heinz-Peter Schultheiss; Carsten Tschöpe
High-density lipoprotein at the interface of type 2 diabetes mellitus and cardiovascular disorders.
Current pharmaceutical design 2010;16(13):1504-16.
2010: Frank Spillmann; Heinz-Peter Schultheiss; Carsten Tschöpe; Sophie Van Linthout
High-density lipoprotein-raising strategies: update 2010.
Current pharmaceutical design 2010;16(13):1517-30.
2010: Konstantinos Savvatis; Dirk Westermann; Heinz-Peter Schultheiss; Carsten Tschöpe
Kinins in cardiac inflammation and regeneration: insights from ischemic and diabetic cardiomyopathy.
Neuropeptides 2010;44(2):119-25.
2010: Caroline Schmidt-Lucke; Frank Spillmann; Thomas Bock; Uwe Kühl; Sophie Van Linthout; Heinz-Peter Schultheiss; Carsten Tschöpe
Interferon beta modulates endothelial damage in patients with cardiac persistence of human parvovirus b19 infection.
The Journal of infectious diseases 2010;201(6):936-45.
2010: Dirk Westermann; Konstantinos Savvatis; Heinz-Peter Schultheiss; Carsten Tschöpe
Immunomodulation and matrix metalloproteinases in viral myocarditis.
Journal of molecular and cellular cardiology 2010;48(3):468-73.
2010: Marion Haag; Sophie Van Linthout; Sebastian E A Schröder; Undine Freymann; Jochen Ringe; Carsten Tschöpe; Michael Sittinger
Endomyocardial biopsy derived adherent proliferating cells - a potential cell source for cardiac tissue engineering.
Journal of cellular biochemistry 2010;109(3):564-75.
2010: Matthias Koch; Konstantinos Savvatis; Michael Scheeler; Sameer Dhayat; Klaus Bonaventura; Thomas Pohl; Alexander Riad; Silvia Bulfone-Paus; Heinz-Peter Schultheiss; Carsten Tschöpe
Immunosuppression with an interleukin-2 fusion protein leads to improved LV function in experimental ischemic cardiomyopathy.
International immunopharmacology 2010;10(2):207-12.
2010: Konstantinos Savvatis; Heinz-Peter Schultheiss; Dirk Westermann; Carsten Tschöpe
First-line treatment of hypertension: critical appraisal of potential role of aliskiren and hydrochlorothiazide in a fixed combination.
Integrated blood pressure control 2010;3():163-70.
2009: Sandra Pinkert; Dirk Westermann; Xiaomin Wang; Karin Klingel; Andrea Dörner; Konstantinos Savvatis; Tobias Grössl; Stefanie Krohn; Carsten Tschöpe; Heinz Zeichhardt; Katja Kotsch; Kerstin Weitmann; Wolfgang Hoffmann; Heinz-Peter Schultheiss; O Brad Spiller; Wolfgang Poller; Henry Fechner
Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor.
Circulation 2009;120(23):2358-66.
2009: Rolf Wachter; Stephan Schmidt-Schweda; Dirk Westermann; Heiner Post; Frank Edelmann; Mario Kasner; Claus Lüers; Paul Steendijk; Gerd Hasenfuss; Carsten Tschöpe; Burkert Pieske
Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure.
European heart journal 2009;30(24):3027-36.
2009: Dirk Westermann; Alexander Riad; Utz Richter; Sebastian Jäger; Konstantinos Savvatis; Mirjam Schuchardt; Nora Bergmann; Markus Tölle; Dirk Nagorsen; Michael Gotthardt; Heinz-Peter Schultheiss; Carsten Tschöpe
Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure.
Basic research in cardiology 2009;104(5):499-509.
2009: Dirk Westermann; Thomas Walther; Konstantinos Savvatis; Felicitas Escher; Meike Sobirey; Alexander Riad; Michael Bader; Heinz-Peter Schultheiss; Carsten Tschöpe
Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy.
Diabetes 2009;58(6):1373-81.
2009: Yu Shi; Chen Chen; Ulrike Lisewski; Uta Wrackmeyer; Michael Radke; Dirk Westermann; Martina Sauter; Carsten Tschöpe; Wolfgang Poller; Karin Klingel; Michael Gotthardt
Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo.
Journal of the American College of Cardiology 2009;53(14):1219-26.
2009: Sophie Van Linthout; Frank Spillmann; Mario Lorenz; Marco Meloni; Frank Jacobs; Marina Egorova; Verena Stangl; Bart De Geest; Heinz-Peter Schultheiss; Carsten Tschöpe
Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor.
Hypertension 2009;53(4):682-7.
2009: Carsten Tschöpe; Dirk Westermann
Heart failure with normal ejection fraction. Pathophysiology, diagnosis, and treatment.
Herz 2009;34(2):89-96.
2009: Alexander Riad; Sandra Bien; Dirk Westermann; Peter M Becher; Komal Loya; Ulf Landmesser; Heyo K Kroemer; Heinz-Peter Schultheiss; Carsten Tschöpe
Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice.
Cancer research 2009;69(2):695-9.
2008: Elena Kaschina; Aleksandra Grzesiak; Jun Li; Anna Foryst-Ludwig; Melanie Timm; Franziska Rompe; Manuela Sommerfeld; U Rudolf Kemnitz; Caterina Curato; Pawel Namsolleck; Carsten Tschöpe; Anders Hallberg; Mathias Alterman; Thomas Hucko; Ingo Paetsch; Thomas Dietrich; Bernhard Schnackenburg; Kristof Graf; Björn Dahlöf; Ulrich Kintscher; Thomas Unger; Ulrike Muscha Steckelings
Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?
Circulation 2008;118(24):2523-32.
2008: Dirk Westermann; Alexander Riad; Olga Lettau; Anton Roks; Konstantinos Savvatis; Peter Moritz Becher; Felicitas Escher; A H Jan Danser; Heinz-Peter Schultheiss; Carsten Tschöpe
Renin inhibition improves cardiac function and remodeling after myocardial infarction independent of blood pressure.
Hypertension 2008;52(6):1068-75.
2008: Alexander Riad; Dirk Westermann; Sophie Van Linthout; Z Mohr; S Uyulmaz; P M Becher; H Rütten; Paulus Wohlfart; H Peters; Heinz-Peter Schultheiss; Carsten Tschöpe
Enhancement of endothelial nitric oxide synthase production reverses vascular dysfunction and inflammation in the hindlimbs of a rat model of diabetes.
Diabetologia 2008;51(12):2325-32.
2008: Matthias Holzmann; Alexander Nicko; Uwe Kühl; Michel Noutsias; Wolfgang Poller; Wolfgang Hoffmann; Andreas Morguet; Bernhard Witzenbichler; Carsten Tschöpe; Heinz-Peter Schultheiss; Matthias Pauschinger
Complication rate of right ventricular endomyocardial biopsy via the femoral approach: a retrospective and prospective study analyzing 3048 diagnostic procedures over an 11-year period.
Circulation 2008;118(17):1722-8.
2008: Linda Ebermann; Frank Spillmann; Melanie Sidiropoulos; Felicitas Escher; Silvia Heringer-Walther; Heinz-Peter Schultheiss; Carsten Tschöpe; Thomas Walther
The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats.
European journal of pharmacology 2008;590(1-3):276-80.
2008: Silvio Antoniak; Ulrike Boltzen; Alexander Riad; Angela Kallwellis-Opara; Maria Rohde; Andrea Dörner; Carsten Tschöpe; Michel Noutsias; Matthias Pauschinger; Heinz-Peter Schultheiss; Ursula Rauch
Viral myocarditis and coagulopathy: increased tissue factor expression and plasma thrombogenicity.
Journal of molecular and cellular cardiology 2008;45(1):118-26.
2008: Sophie Van Linthout; Ute Seeland; Alexander Riad; Oleg Eckhardt; Mathias Hohl; Nasser Dhayat; Utz Richter; Jens W Fischer; Michael Böhm; Matthias Pauschinger; Heinz-Peter Schultheiss; Carsten Tschöpe
Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy.
Basic research in cardiology 2008;103(4):319-27.
2008: Dirk Westermann; Olga Lettau; Meike Sobirey; Alexander Riad; Michael Bader; Heinz-Peter Schultheiss; Carsten Tschöpe
Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuated by gene deletion of the kinin B1 receptor.
Biological chemistry 2008;389(6):713-8.
2008: Matthias Koch; Klaus Bonaventura; Frank Spillmann; Andreas Dendorfer; Heinz-Peter Schultheiss; Carsten Tschöpe
Attenuation of left ventricular dysfunction by an ACE inhibitor after myocardial infarction in a kininogen-deficient rat model.
Biological chemistry 2008;389(6):719-23.
2008: Carsten Tschöpe; Dirk Westermann
Development of diabetic cardiomyopathy and the kallikrein-kinin system--new insights from B1 and B2 receptor signaling.
Biological chemistry 2008;389(6):707-11.
2008: Philipp Kalk; Dirk Westermann; Sophia Herzfeld; Katharina Relle; Thiemo Pfab; Christian Bauer; Carsten Tschöpe; Johannes-Peter Stasch; Berthold Hocher
Additional lack of iNOS attenuates diastolic dysfunction in aged ET-1 transgenic mice.
Canadian journal of physiology and pharmacology 2008;86(6):353-7.
2008: Dirk Westermann; Roland Schmieder; Heinz-Peter Schultheiss; Carsten Tschöpe
Renin inhibitors, clinical experience.
Journal of molecular medicine (Berlin, Germany) 2008;86(6):691-5.
2008: Alexander Riad; Sebastian Jäger; Meike Sobirey; Felicitas Escher; Aymaru Yaulema-Riss; Dirk Westermann; Aysun Karatas; Markus M Heimesaat; Stefan Bereswill; Duska Dragun; Matthias Pauschinger; Heinz-Peter Schultheiss; Carsten Tschöpe
Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6954-61.
2008: Dirk Westermann; Mario Kasner; Paul Steendijk; Frank Spillmann; Alexander Riad; Kerstin Weitmann; Wolfgang Hoffmann; Wolfgang Poller; Matthias Pauschinger; Heinz-Peter Schultheiss; Carsten Tschöpe
Role of left ventricular stiffness in heart failure with normal ejection fraction.
Circulation 2008;117(16):2051-60.
2008: Sophie Van Linthout; Frank Spillmann; Alexander Riad; Christiane Trimpert; joke lievens; Marco Meloni; Felicitas Escher; Elena Filenberg; Okan Demir; Jun Li; Mehdi Shakibaei; Ingolf Schimke; Alexander Staudt; Stephan B Felix; Heinz-Peter Schultheiss; Bart De Geest; Carsten Tschöpe
Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy.
Circulation 2008;117(12):1563-73.
2008: Dirk Westermann; J Mersmann; A Melchior; T Freudenberger; C Petrik; L Schaefer; R Lüllmann-Rauch; O Lettau; C Jacoby; J Schrader; S-M Brand-Herrmann; M F Young; Heinz-Peter Schultheiss; Bodo Levkau; H A Baba; Thomas Unger; K Zacharowski; Carsten Tschöpe; Jens W Fischer
Biglycan is required for adaptive remodeling after myocardial infarction.
Circulation 2008;117(10):1269-76.
2008: Alexander Riad; Sandra Bien; Matthias Gratz; Felicitas Escher; Dirk Westermann; Markus M Heimesaat; Stefan Bereswill; Thomas Krieg; Stephan B Felix; Heinz-Peter Schultheiss; Heyo K Kroemer; Carsten Tschöpe
Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice.
European journal of heart failure 2008;10(3):233-43.
2008: Alexander Riad; Thomas Walther; J Yang; Christine Altmann; Felicitas Escher; Dirk Westermann; Frank Spillmann; Heinz-Peter Schultheiss; Carsten Tschöpe
The cardiovascular influence of interleukin-1 beta on the expression of bradykinin B1 and B2 receptors.
International immunopharmacology 2008;8(2):222-30.
2008: Dirk Westermann; Heinz-Peter Schultheiss; Carsten Tschöpe
New perspective on the tissue kallikrein-kinin system in myocardial infarction: role of angiogenesis and cardiac regeneration.
International immunopharmacology 2008;8(2):148-54.
2008: Daniela Fliegner; Dirk Westermann; Alexander Riad; Carola Schubert; Eva Becher; Jens Fielitz; Carsten Tschöpe; Vera Regitz-Zagrosek
Up-regulation of PPARgamma in myocardial infarction.
European journal of heart failure 2008;10(1):30-8.
2007: Sandra Bien; Alexander Riad; Christoph A Ritter; Matthias Gratz; Florian Olshausen; Dirk Westermann; Markus Grube; Thomas Krieg; Sabine Ciecholewski; Stephan B Felix; Alexander Staudt; Heinz-Peter Schultheiss; Ralf Ewert; Uwe Völker; Carsten Tschöpe; Heyo K Kroemer
The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy.
Cancer research 2007;67(21):10428-35.
2007: Dirk Westermann; Sophie Van Linthout; Sameer Dhayat; Nasser Dhayat; Annette Schmidt; Michel Noutsias; Xi-Yong Song; Frank Spillmann; Alexander Riad; Heinz-Peter Schultheiss; Carsten Tschöpe
Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy.
Basic research in cardiology 2007;102(6):500-7.
2007: Sophie Van Linthout; Alexander Riad; Nasser Dhayat; Frank Spillmann; Jing Du; Sameer Dhayat; Dirk Westermann; D Hilfiker-Kleiner; Michel Noutsias; U Laufs; Heinz-Peter Schultheiss; Carsten Tschöpe
Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy.
Diabetologia 2007;50(9):1977-86.
2007: Alexander Riad; Jing Du; Sebastian Stiehl; Dirk Westermann; Zarah Mohr; Meike Sobirey; Wolfram Doehner; Volker Adams; Matthias Pauschinger; Heinz-Peter Schultheiss; Carsten Tschöpe
Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus.
European journal of pharmacology 2007;569(3):204-11.
2007: Mario Kasner; Dirk Westermann; Paul Steendijk; Regina Gaub; Ursula Wilkenshoff; Kerstin Weitmann; Wolfgang Hoffmann; Wolfgang Poller; Heinz-Peter Schultheiss; Matthias Pauschinger; Carsten Tschöpe
Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler-conductance catheterization study.
Circulation 2007;116(6):637-47.
2007: Dirk Westermann; Sophie Van Linthout; Sameer Dhayat; Nasser Dhayat; Felicitas Escher; Carola Bücker-Gärtner; Frank Spillmann; Michel Noutsias; Alexander Riad; Heinz-Peter Schultheiss; Carsten Tschöpe
Cardioprotective and anti-inflammatory effects of interleukin converting enzyme inhibition in experimental diabetic cardiomyopathy.
Diabetes 2007;56(7):1834-41.
2007: Dirk Westermann; Susanne Rutschow; Sebastian Jäger; Anne Linderer; Stefan Anker; Alexander Riad; Thomas Unger; Heinz-Peter Schultheiss; Matthias Pauschinger; Carsten Tschöpe
Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism.
Diabetes 2007;56(3):641-6.
2007: Thomas Walther; Carsten Tschöpe; Anja Sterner-Kock; Dirk Westermann; Silvia Heringer-Walther; Alexander Riad; Alen Nikolic; Yong Wang; Linda Ebermann; Wolf-Eberhard Siems; Michael Bader; Mehdi Shakibaei; Heinz-Peter Schultheiss; Andrea Dörner
Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease.
Circulation 2007;115(3):333-44.
2007: Alexander Riad; Daniel Unger; Jing Du; Dirk Westermann; Zarah Mohr; Meike Sobirey; Marc Dorenkamp; Heinz-Peter Schultheiss; Carsten Tschöpe
Chronic inhibition of p38MAPK improves cardiac and endothelial function in experimental diabetes mellitus.
European journal of pharmacology 2007;554(1):40-5.
2007: Alexander Riad; Jia L Zhuo; Heinz-Peter Schultheiss; Carsten Tschöpe
The role of the renal kallikrein-kinin system in diabetic nephropathy.
Current opinion in nephrology and hypertension 2007;16(1):22-6.
2006: Matthias Koch; Frank Spillmann; Andreas Dendorfer; Dirk Westermann; Christine Altmann; Merdad Sahabi; Sophie Van Linthout; Michael Bader; Thomas Walther; Heinz-Peter Schultheiss; Carsten Tschöpe
Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction.
European journal of pharmacology 2006;550(1-3):143-8.
2006: Carsten Tschöpe; Heinz-Peter Schultheiss
[Cardioprotection by means of Candesartan in cardiac insufficiency. CHARM overall partial evaluation (Candesartan in heart failure assessment of reduction in mortality and morbidity)].
Der Internist 2006;47(10):1084-6.
2006: Dirk Westermann; Susanne Rutschow; Sophie Van Linthout; A Linderer; C Bücker-Gärtner; Meike Sobirey; Alexander Riad; Matthias Pauschinger; Heinz-Peter Schultheiss; Carsten Tschöpe
Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus.
Diabetologia 2006;49(10):2507-13.
2006: Carsten Tschöpe; R Tschöpe; T Unger
[Microalbuminuria in patients with hypertension and cardiovascular comorbidity, REAL observational study of treatment with Irbesartan/HCTZ].
MMW Fortschritte der Medizin 2006;148(25):48.
2006: Carsten Tschöpe; Dirk Westermann; Paul Steendijk; Mario Kasner; Martin Rudwaleit; Peter L Schwimmbeck; Wolfgang Poller; Heinz-Peter Schultheiss
Coronary vasospasm-induced acute diastolic dysfunction in a patient with Raynaud's phenomenon.
Clinical research in cardiology : official journal of the German Cardiac Society 2006;95(6):344-8.
2006: Frank Spillmann; Gallia Graiani; Sophie Van Linthout; Marco Meloni; Ilaria Campesi; Costanza Lagrasta; Dirk Westermann; Carsten Tschöpe; Federico Quaini; Costanza Emanueli; Paolo Madeddu
Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium.
Regenerative medicine 2006;1(2):235-54.
2006: Dirk Westermann; Björn C Knollmann; Paul Steendijk; Susanne Rutschow; Alexander Riad; Matthias Pauschinger; James D Potter; Heinz-Peter Schultheiss; Carsten Tschöpe
Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy.
European journal of heart failure 2006;8(2):115-21.
2006: Frank Spillmann; Sophie Van Linthout; Heinz-Peter Schultheiss; Carsten Tschöpe
Cardioprotective mechanisms of the kallikrein-kinin system in diabetic cardiopathy.
Current opinion in nephrology and hypertension 2006;15(1):22-9.
2005: Carsten Tschöpe; Thomas Walther; Felicitas Escher; Frank Spillmann; Jing Du; Christine Altmann; Ingolf Schimke; Michael Bader; Carlos F Sanchez-Ferrer; Heinz-Peter Schultheiss; Michel Noutsias
Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2057-9.
2005: Carsten Tschöpe; Mario Kasner; Dirk Westermann; Regina Gaub; Wolfgang Poller; Heinz-Peter Schultheiss
The role of NT-proBNP in the diagnostics of isolated diastolic dysfunction: correlation with echocardiographic and invasive measurements.
European heart journal 2005;26(21):2277-84.
2005: Marc Dorenkamp; Alexander Riad; Sebastian Stiehl; Frank Spillmann; Dirk Westermann; Jing Du; Matthias Pauschinger; Michel Noutsias; Volker Adams; Heinz-Peter Schultheiss; Carsten Tschöpe
Protection against oxidative stress in diabetic rats: role of angiotensin AT(1) receptor and beta 1-adrenoceptor antagonism.
European journal of pharmacology 2005;520(1-3):179-87.
2005: Carsten Tschöpe; Mario Kasner; Dirk Westermann; Thomas Walther; Regina Gaub; Wolfgang Poller; Heinz-Peter Schultheiss
Elevated NT-ProBNP levels in patients with increased left ventricular filling pressure during exercise despite preserved systolic function.
Journal of cardiac failure 2005;11(5 Suppl):S28-33.
2005: Carsten Tschöpe; C-T Bock; Mario Kasner; Michel Noutsias; Dirk Westermann; Peter L Schwimmbeck; Matthias Pauschinger; Wolfgang Poller; Uwe Kühl; Reinhard Kandolf; Heinz-Peter Schultheiss
High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction.
Circulation 2005;111(7):879-86.
2005: Carsten Tschöpe; Dirk Westermann; Nasser Dhayat; Sameer Dhayat; Christine Altmann; Paul Steendijk; Heinz-Peter Schultheiss; Thomas Walther
Angiotensin AT2 receptor deficiency after myocardial infarction: its effects on cardiac function and fibrosis depend on the stimulus.
Cell biochemistry and biophysics 2005;43(1):45-52.
2004: Carsten Tschöpe; Frank Spillmann; Uwe Rehfeld; Matthias Koch; Dirk Westermann; Christine Altmann; Andreas Dendorfer; Thomas Walther; Michael Bader; Martin Paul; Heinz-Peter Schultheiss; Roland Vetter
Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1967-9.
2004: Thomas Walther; Paul Steendijk; Dirk Westermann; Claudia Hohmann; Karsten Schulze; Silvia Heringer-Walther; Heinz-Peter Schultheiss; Carsten Tschöpe
Angiotensin deficiency in mice leads to dilated cardiomyopathy.
European journal of pharmacology 2004;493(1-3):161-5.
2004: Carsten Tschöpe; Dirk Westermann; Paul Steendijk; Michel Noutsias; Susanne Rutschow; Anneke Weitz; Peter L Schwimmbeck; Heinz-Peter Schultheiss; Matthias Pauschinger
Hemodynamic characterization of left ventricular function in experimental coxsackieviral myocarditis: effects of carvedilol and metoprolol.
European journal of pharmacology 2004;491(2-3):173-9.
2004: Carsten Tschöpe; Thomas Walther; Jens Königer; Frank Spillmann; Dirk Westermann; Felicitas Escher; Matthias Pauschinger; João B Pesquero; Michael Bader; Heinz-Peter Schultheiss; Michel Noutsias
Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):828-35.
2004: Carsten Tschöpe; Frank Spillmann; Christine Altmann; Matthias Koch; Dirk Westermann; Nasser Dhayat; Sameer Dhayat; Jean-Loup Bascands; Lajos Gera; Sigrid Hoffmann; Heinz-Peter Schultheiss; Thomas Walther
The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarction.
Cardiovascular research 2004;61(3):559-69.
2003: Thomas Walther; Katrin Klostermann; Silvia Heringer-Walther; Heinz-Peter Schultheiss; Carsten Tschöpe; Holger Stepan
Fibrosis rather than blood pressure determines cardiac BNP expression in mice.
Regulatory peptides 2003;116(1-3):95-100.
2003: Carsten Tschöpe; Heinz-Peter Schultheiss
[Diabetic cardiopathy: pathogenesis, diagnosis and therapy].
Der Internist 2003;44(7):806-12, 814-8.
2003: Matthias Koch; Michael Wendorf; Andreas Dendorfer; Sebastian Wolfrum; Karsten Schulze; Frank Spillmann; Heinz-Peter Schultheiss; Carsten Tschöpe
Cardiac kinin level in experimental diabetes mellitus: role of kininases.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H418-23.
2003: Carsten Tschöpe; Ulrich Seidl; Alexander Reinecke; Udo Riester; Kristof Graf; Heinz-Peter Schultheiss; Ulrich Hilgenfeldt; Thomas Unger
Kinins are involved in the antiproteinuric effect of angiotensin-converting enzyme inhibition in experimental diabetic nephropathy.
International immunopharmacology 2003;3(3):335-44.
2002: Claude Braun; Thomas Kleemann; Rainer Birck; Ulrich Hilgenfeldt; Udo Riester; Carsten Tschöpe; Fokko J van der Woude; Peter Rohmeiss
Increased activity of the renal kallikrein-kinin system in autosomal dominant polycystic kidney disease in rats, but not in humans.
International immunopharmacology 2002;2(13-14):1949-56.
2002: Frank Spillmann; Christine Altmann; Michael Scheeler; Marcos Barbosa; Dirk Westermann; Heinz-Peter Schultheiss; Thomas Walther; Carsten Tschöpe
Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy.
International immunopharmacology 2002;2(13-14):1823-32.
2002: Roland Vetter; Uwe Rehfeld; Christoph Reissfelder; Wolfgang Weiss; Kay-Dietrich Wagner; Joachim Günther; Annette Hammes; Carsten Tschöpe; Wolfgang Dillmann; Martin Paul
Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1657-9.
2002: Heinz-Peter Schultheiss; Carsten Tschöpe
[Beta blockers in post-infarction state].
Herz 2002;27 Suppl 1():26-9.
2002: Thomas Walther; Wolf-Eberhard Siems; Dorian Hauke; Frank Spillmann; Andreas Dendorfer; Winfried Krause; Heinz-Peter Schultheiss; Carsten Tschöpe
AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1237-41.
2002: Thomas Walther; Heinz-Peter Schultheiss; Carsten Tschöpe; Holger Stepan
Natriuretic peptide system in fetal heart and circulation.
Journal of hypertension 2002;20(5):785-91.
2002: Carsten Tschöpe; Heinz-Peter Schultheiss; Thomas Walther
Multiple interactions between the renin-angiotensin and the kallikrein-kinin systems: role of ACE inhibition and AT1 receptor blockade.
Journal of cardiovascular pharmacology 2002;39(4):478-87.
2001: Thomas Walther; H P Schuitheiss; Carsten Tschöpe
Impaired angiotensin II regulation of renal C-type natriuretic peptide mRNA expression in experimental diabetes mellitus.
Cardiovascular research 2001;51(3):562-6.
2000: Christian Seligmann; Mike Schimmer; Tobias Leitsch; Andreas Bock; Yusuf Simsek; Carsten Tschöpe; Heinz-Peter Schultheiss
A thrombocyte-induced myocardial dysfunction in the ischemic and reperfused guinea pig heart is mediated by reactive oxygen species.
Free radical biology & medicine 2000;29(12):1244-51.
2000: Jose Silva Junior; Ronaldo C Araujo; Ovidiu Constantin Baltatu; S M Oliveira; Carsten Tschöpe; E Fink; Sigrid Hoffmann; Ralph Plehm; K X Chai; Lee Chao; Julie Chao; Detlev Ganten; João B Pesquero; Michael Bader
Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):1858-60.
2000: Carsten Tschöpe; Silvia Heringer-Walther; Thomas Walther
Regulation of the kinin receptors after induction of myocardial infarction: a mini-review.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2000;33(6):701-8.
2000: Thomas Walther; Silvia Heringer-Walther; R Tschöpe; Alexander Reinecke; Heinz-Peter Schultheiss; Carsten Tschöpe
Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy.
Journal of molecular endocrinology 2000;24(3):391-5.
2000: Carsten Tschöpe; Silvia Heringer-Walther; Matthias Koch; Frank Spillmann; Michael Wendorf; E Leitner; Heinz-Peter Schultheiss; Thomas Walther
Upregulation of bradykinin B1-receptor expression after myocardial infarction.
British journal of pharmacology 2000;129(8):1537-8.
2000: Carsten Tschöpe; Silvia Heringer-Walther; Matthias Koch; Frank Spillmann; Michael Wendorf; D Hauke; Michael Bader; Heinz-Peter Schultheiss; Thomas Walther
Myocardial bradykinin B2-receptor expression at different time points after induction of myocardial infarction.
Journal of hypertension 2000;18(2):223-8.
1999: Carsten Tschöpe; Alexander Reinecke; U Seidl; M Yu; V Gavriluk; Udo Riester; Peter Gohlke; Kristof Graf; Michael Bader; Ulrich Hilgenfeldt; JB Pesquero; E Ritz; Thomas Unger
Functional, biochemical, and molecular investigations of renal kallikrein-kinin system in diabetic rats.
The American journal of physiology 1999;277(6 Pt 2):H2333-40.
1999: Carsten Tschöpe; Matthias Koch; Frank Spillmann; Silvia Heringer-Walther; H C Mochmann; H Stauss; Michael Bader; Thomas Unger; Heinz-Peter Schultheiss; Thomas Walther
Upregulation of the cardiac bradykinin B2 receptors after myocardial infarction.
Immunopharmacology 1999;44(1-2):111-7.
1999: Carsten Tschöpe; Thomas Walther; M Yu; Alexander Reinecke; Matthias Koch; Christian Seligmann; S B Heringer; JB Pesquero; Michael Bader; Heinz-Peter Schultheiss; Thomas Unger
Myocardial expression of rat bradykinin receptors and two tissue kallikrein genes in experimental diabetes.
Immunopharmacology 1999;44(1-2):35-42.
1998: Jens W Fischer; Carsten Tschöpe; Alexander Reinecke; Cecilia M Giachelli; Thomas Unger
Upregulation of osteopontin expression in renal cortex of streptozotocin-induced diabetic rats is mediated by bradykinin.
Diabetes 1998;47(9):1512-8.
1998: Michael Halank; M Wiemer; Carsten Tschöpe; Wolfgang Poller; Peter L Schwimmbeck; Dieter Horstkotte; Gert Höffken
[Precapillary pulmonary hypertension of uncertain etiology].
Deutsche medizinische Wochenschrift (1946) 1998;123(28-29):861-5.
1997: Carsten Tschöpe; M Yu; Alexander Reinecke; T Csikos; Ulrich Hilgenfeldt; JB Pesquero; E Ritz; Thomas Unger
Renal expression of two rat kallikrein genes under diabetic conditions.
Journal of hypertension 1997;15(12 Pt 2):1711-4.
1997: Carsten Tschöpe; Peter Gohlke; Y Z Zhu; Wolfgang Linz; BA Schölkens; Thomas Unger
Antihypertensive and cardioprotective effects after angiotensin-converting enzyme inhibition: role of kinins.
Journal of cardiac failure 1997;3(2):133-48.
1996: Carsten Tschöpe; V Gavriluk; Alexander Reinecke; U Seidl; Udo Riester; Ulrich Hilgenfeldt; E Ritz; Thomas Unger
Bradykinin excretion is increased in severely hyperglycemic streptozotocin-diabetic rats.
Immunopharmacology 1996;33(1-3):344-8.
1995: Carsten Tschöpe; N Jost; Thomas Unger; Juraj Culman
Central cardiovascular and behavioral effects of carboxy- and amino-terminal fragments of substance P in conscious rats.
Brain research 1995;690(1):15-24.
1995: P Rohmeiss; C Beyer; E Nagy; Carsten Tschöpe; S Höhle; M Strauch; Thomas Unger
NaCl injections in brain induce natriuresis and blood pressure responses sensitive to ANG II AT1 receptors.
The American journal of physiology 1995;269(2 Pt 2):F282-8.
1994: Keiichi Itoi; N Jost; Juraj Culman; Carsten Tschöpe; Thomas Unger
Further localization of cardiovascular and behavioral actions of substance P in the rat brain.
Brain research 1994;668(1-2):100-6.
1994: Keiichi Itoi; N Jost; Carsten Tschöpe; Juraj Culman; E Badoer; Thomas Unger
Inhibition by morphine of the cardiovascular and behavioral responses evoked by centrally administered substance P in conscious rats.
Neuropharmacology 1994;33(2):181-7.
1993: Juraj Culman; Carsten Tschöpe; N Jost; Keiichi Itoi; Thomas Unger
Substance P and neurokinin A induced desensitization to cardiovascular and behavioral effects: evidence for the involvement of different tachykinin receptors.
Brain research 1993;625(1):75-83.
1993: Juraj Culman; Carsten Tschöpe; P Picard; A Prat; D Regoli; R Couture; Thomas Unger
In vivo characterization of tachykinin receptors responsible for the central cardiovascular effects of substance P and neurokinin A.
Regulatory peptides 1993;46(1-2):364-6.
1992: Carsten Tschöpe; P Picard; J Culman; A Prat; Keiichi Itoi; D Regoli; Thomas Unger; R Couture
Use of selective antagonists to dissociate the central cardiovascular and behavioural effects of tachykinins on NK1 and NK2 receptors in the rat.
British journal of pharmacology 1992;107(3):750-5.
1992: Keiichi Itoi; Carsten Tschöpe; N Jost; Juraj Culman; CJ Lebrun; B Stauss; Thomas Unger
Identification of the central tachykinin receptor subclass involved in substance P-induced cardiovascular and behavioral responses in conscious rats.
European journal of pharmacology 1992;219(3):435-44.
1991: Keiichi Itoi; N Jost; E Badoer; Carsten Tschöpe; Juraj Culman; Thomas Unger
Localization of the substance P-induced cardiovascular responses in the rat hypothalamus.
Brain research 1991;558(1):123-6.