Jürg Tschopp

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Rebsamen Manuele; Heinz Leonhard X; Meylan Etienne; Michallet Marie-Cécile; Schroder Kate; Hofmann Kay; Vazquez Jessica; Benedict Chris A; Tschopp Jürg
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
Guarda Greta; Dostert Catherine; Staehli Francesco; Cabalzar Katrin; Castillo Rosa; Tardivel Aubry; Schneider Pascal; Tschopp Jürg
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Gross Olaf; Poeck Hendrik; Bscheider Michael; Dostert Catherine; Hannesschläger Nicole; Endres Stefan; Hartmann Gunther; Tardivel Aubry; Schweighoffer Edina; Tybulewicz Victor; Mocsai Attila; Tschopp Jürg; Ruland Jürgen
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.

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2009: Rebsamen Manuele; Heinz Leonhard X; Meylan Etienne; Michallet Marie-Cécile; Schroder Kate; Hofmann Kay; Vazquez Jessica; Benedict Chris A; Tschopp Jürg
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
EMBO reports 2009;10(8):916-22.
2009: Guarda Greta; Dostert Catherine; Staehli Francesco; Cabalzar Katrin; Castillo Rosa; Tardivel Aubry; Schneider Pascal; Tschopp Jürg
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Nature 2009;460(7252):269-73.
2009: Gross Olaf; Poeck Hendrik; Bscheider Michael; Dostert Catherine; Hannesschläger Nicole; Endres Stefan; Hartmann Gunther; Tardivel Aubry; Schweighoffer Edina; Tybulewicz Victor; Mocsai Attila; Tschopp Jürg; Ruland Jürgen
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
Nature 2009;459(7245):433-6.
2009: Gasse Pamela; Riteau Nicolas; Charron Sabine; Girre Sandra; Fick Lizette; Pétrilli Virginie; Tschopp Jürg; Lagente Vincent; Quesniaux Valérie F J; Ryffel Bernhard; Couillin Isabelle
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.
American journal of respiratory and critical care medicine 2009;179(10):903-13.
2009: Manzl Claudia; Krumschnabel Gerhard; Bock Florian; Sohm Benedicte; Labi Verena; Baumgartner Florian; Logette Emmanuelle; Tschopp Jürg; Villunger Andreas
Caspase-2 activation in the absence of PIDDosome formation.
The Journal of cell biology 2009;185(2):291-303.
2009: Schroder Kate; Muruve Daniel A; Tschopp Jürg
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.
Current biology : CB 2009;19(6):R262-5.
2009: Martinon Fabio; Mayor Annick; Tschopp Jürg
The inflammasomes: guardians of the body.
Annual review of immunology 2009;27():229-65.
2008: Rebsamen M; Meylan E; Curran J; Tschopp J
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Cell death and differentiation 2008;15(11):1804-11.
2008: Kool Mirjam; Pétrilli Virginie; De Smedt Thibaut; Rolaz Aline; Hammad Hamida; van Nimwegen Menno; Bergen Ingrid M; Castillo Rosa; Lambrecht Bart N; Tschopp Jürg
Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):3755-9.
2008: Ermolaeva Maria A; Michallet Marie-Cécile; Papadopoulou Nikoletta; Utermöhlen Olaf; Kranidioti Ksanthi; Kollias George; Tschopp Jürg; Pasparakis Manolis
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses.
Nature immunology 2008;9(9):1037-46.
2008: Meylan Etienne; Tschopp Jürg
IRAK2 takes its place in TLR signaling.
Nature immunology 2008;9(6):581-2.
2008: Michallet Marie-Cécile; Meylan Etienne; Ermolaeva Maria A; Vazquez Jessica; Rebsamen Manuele; Curran Joseph; Poeck Hendrik; Bscheider Michael; Hartmann Gunther; König Martin; Kalinke Ulrich; Pasparakis Manolis; Tschopp Jürg
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Immunity 2008;28(5):651-61.
2008: Watanabe Hideki; Gehrke Samuel; Contassot Emmanuel; Roques Stéphanie; Tschopp Jürg; Friedmann Peter S; French Lars E; Gaide Olivier
Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5826-32.
2008: Dostert Catherine; Pétrilli Virginie; Van Bruggen Robin; Steele Chad; Mossman Brooke T; Tschopp Jürg
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Science (New York, N.Y.) 2008;320(5876):674-7.
2008: Dostert Catherine; Meylan Etienne; Tschopp Jürg
Intracellular pattern-recognition receptors.
Advanced drug delivery reviews 2008;60(7):830-40.
2008: Meylan Etienne; Tschopp Jürg
NLRX1: friend or foe?
EMBO reports 2008;9(3):243-5.
2008: Bossen Claudia; Cachero Teresa G; Tardivel Aubry; Ingold Karine; Willen Laure; Dobles Max; Scott Martin L; Maquelin Aris; Belnoue Elodie; Siegrist Claire-Anne; Chevrier Stéphane; Acha-Orbea Hans; Leung Helen; Mackay Fabienne; Tschopp Jürg; Schneider Pascal
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.
Blood 2008;111(3):1004-12.
2008: Cuenin S; Tinel A; Janssens S; Tschopp J
p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress.
Oncogene 2008;27(3):387-96.
2007: Pétrilli Virginie; Dostert Catherine; Muruve Daniel A; Tschopp Jürg
The inflammasome: a danger sensing complex triggering innate immunity.
Current opinion in immunology 2007;19(6):615-22.
2007: Etter Anne-Lise; Bassi Isabelle; Germain Stéphane; Delaloye Jean-François; Tschopp Jürg; Sordat Bernard; Dupuis Marc
The combination of chemotherapy and intraperitoneal MegaFas Ligand improves treatment of ovarian carcinoma.
Gynecologic oncology 2007;107(1):14-21.
2007: Martinon Fabio; Gaide Olivier; Pétrilli Virgine; Mayor Annick; Tschopp Jürg
NALP inflammasomes: a central role in innate immunity.
Seminars in immunopathology 2007;29(3):213-29.
2007: Pétrilli V; Papin S; Dostert C; Mayor A; Martinon F; Tschopp J
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration.
Cell death and differentiation 2007;14(9):1583-9.
2007: Kummer J A; Micheau O; Schneider P; Bovenschen N; Broekhuizen R; Quadir R; Strik M C M; Hack C E; Tschopp J
Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis.
Cell death and differentiation 2007;14(8):1486-96.
2007: Papin S; Cuenin S; Agostini L; Martinon F; Werner S; Beer H-D; Grütter C; Grütter M; Tschopp J
The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.
Cell death and differentiation 2007;14(8):1457-66.
2007: Watanabe Hideki; Gaide Olivier; Pétrilli Virginie; Martinon Fabio; Contassot Emmanuel; Roques Stéphanie; Kummer Jean A; Tschopp Jürg; French Lars E
Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity.
The Journal of investigative dermatology 2007;127(8):1956-63.
2007: Mayor Annick; Martinon Fabio; De Smedt Thibaut; Pétrilli Virginie; Tschopp Jürg
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses.
Nature immunology 2007;8(5):497-503.
2007: Kummer J Alain; Broekhuizen Roel; Everett Helen; Agostini Laetitia; Kuijk Loes; Martinon Fabio; van Bruggen Robin; Tschopp Jürg
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(5):443-52.
2007: Park Hyun Ho; Logette Emmanuelle; Raunser Stefan; Cuenin Solange; Walz Thomas; Tschopp Jurg; Wu Hao
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex.
Cell 2007;128(3):533-46.
2007: Tinel Antoine; Janssens Sophie; Lippens Saskia; Cuenin Solange; Logette Emmanuelle; Jaccard Bastienne; Quadroni Manfredo; Tschopp Jürg
Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.
The EMBO journal 2007;26(1):197-208.
2007: Martinon F; Tschopp J
Inflammatory caspases and inflammasomes: master switches of inflammation.
Cell death and differentiation 2007;14(1):10-22.
2007: So Alexander; De Smedt Thibaut; Revaz Sylvie; Tschopp Jürg
A pilot study of IL-1 inhibition by anakinra in acute gout.
Arthritis research & therapy 2007;9(2):R28.
2006: Brissoni Brian; Agostini Laetitia; Kropf Michel; Martinon Fabio; Swoboda Valentin; Lippens Saskia; Everett Helen; Aebi Natalia; Janssens Sophie; Meylan Etienne; Felberbaum-Corti Michela; Hirling Harald; Gruenberg Jean; Tschopp Jürg; Burns Kimberly
Intracellular trafficking of interleukin-1 receptor I requires Tollip.
Current biology : CB 2006;16(22):2265-70.
2006: Munding C; Keller M; Niklaus G; Papin S; Tschopp J; Werner S; Beer H-D
The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion.
Cell death and differentiation 2006;13(11):1938-49.
2006: Gurcel Laure; Abrami Laurence; Girardin Stephen; Tschopp Jurg; van der Goot F Gisou
Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival.
Cell 2006;126(6):1135-45.
2006: Thurau M; Everett H; Tapernoux M; Tschopp J; Thome M
The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis.
Cell death and differentiation 2006;13(9):1577-85.
2006: Meylan Etienne; Tschopp Jürg; Karin Michael
Intracellular pattern recognition receptors in the host response.
Nature 2006;442(7098):39-44.
2006: Meylan Etienne; Tschopp Jürg
Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses.
Molecular cell 2006;22(5):561-9.
2006: Bossen Claudia; Ingold Karine; Tardivel Aubry; Bodmer Jean-Luc; Gaide Olivier; Hertig Sylvie; Ambrose Christine; Tschopp Jürg; Schneider Pascal
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human.
The Journal of biological chemistry 2006;281(20):13964-71.
2006: Janssens S; Tschopp J
Signals from within: the DNA-damage-induced NF-kappaB response.
Cell death and differentiation 2006;13(5):773-84.
2006: Budd Ralph C; Yeh Wen-Chen; Tschopp Jürg
cFLIP regulation of lymphocyte activation and development.
Nature reviews. Immunology 2006;6(3):196-204.
2006: Martinon Fabio; Pétrilli Virginie; Mayor Annick; Tardivel Aubry; Tschopp Jürg
Gout-associated uric acid crystals activate the NALP3 inflammasome.
Nature 2006;440(7081):237-41.
2006: Didierlaurent Arnaud; Brissoni Brian; Velin Dominique; Aebi Natalia; Tardivel Aubry; Käslin Edgar; Sirard Jean Claude; Angelov Georgi; Tschopp Jürg; Burns Kimberly
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.
Molecular and cellular biology 2006;26(3):735-42.
2006: Grütter Christian; Briand Christophe; Capitani Guido; Mittl Peer R E; Papin Stephanie; Tschopp Jürg; Grütter Markus G
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.
FEBS letters 2006;580(1):99-106.
2005: Janssens Sophie; Tinel Antoine; Lippens Saskia; Tschopp Jürg
PIDD mediates NF-kappaB activation in response to DNA damage.
Cell 2005;123(6):1079-92.
2005: Meylan Etienne; Curran Joseph; Hofmann Kay; Moradpour Darius; Binder Marco; Bartenschlager Ralf; Tschopp Jürg
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Nature 2005;437(7062):1167-72.
2005: Petrilli Virginie; Papin Stéphanie; Tschopp Jürg
The inflammasome.
Current biology : CB 2005;15(15):R581.
2005: Martinon Fabio; Tschopp Jürg
NLRs join TLRs as innate sensors of pathogens.
Trends in immunology 2005;26(8):447-54.
2005: Dohrman Austin; Russell Jennifer Q; Cuenin Solange; Fortner Karen; Tschopp Jürg; Budd Ralph C
Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):311-8.
2005: Ingold Karine; Zumsteg Adrian; Tardivel Aubry; Huard Bertrand; Steiner Quynh-Giao; Cachero Teresa G; Qiang Fang; Gorelik Leonid; Kalled Susan L; Acha-Orbea Hans; Rennert Paul D; Tschopp Jürg; Schneider Pascal
Identification of proteoglycans as the APRIL-specific binding partners.
The Journal of experimental medicine 2005;201(9):1375-83.
2005: Dohrman Austin; Kataoka Takao; Cuenin Solange; Russell Jennifer Q; Tschopp Jurg; Budd Ralph C
Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5270-8.
2005: Meylan Etienne; Tschopp Jürg
The RIP kinases: crucial integrators of cellular stress.
Trends in biochemical sciences 2005;30(3):151-9.
2004: Martinon Fabio; Agostini Laetitia; Meylan Etienne; Tschopp Jürg
Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.
Current biology : CB 2004;14(21):1929-34.
2004: Martinon Fabio; Tschopp Jürg
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Cell 2004;117(5):561-74.
2004: Tinel Antoine; Tschopp Jürg
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.
Science (New York, N.Y.) 2004;304(5672):843-6.
2004: Meylan Etienne; Burns Kim; Hofmann Kay; Blancheteau Vincent; Martinon Fabio; Kelliher Michelle; Tschopp Jürg
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
Nature immunology 2004;5(5):503-7.
2004: Wu Wenfang; Rinaldi Lisa; Fortner Karen A; Russell Jennifer Q; Tschopp Jürg; Irvin Charles; Budd Ralph C
Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4724-32.
2004: Agostini Laetitia; Martinon Fabio; Burns Kimberly; McDermott Michael F; Hawkins Philip N; Tschopp Jürg
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Immunity 2004;20(3):319-25.
2004: Huard Bertrand; Arlettaz Lionel; Ambrose Christine; Kindler Vincent; Mauri Davide; Roosnek Eddy; Tschopp Jürg; Schneider Pascal; French Lars E
BAFF production by antigen-presenting cells provides T cell co-stimulation.
International immunology 2004;16(3):467-75.
2004: Tardivel Aubry; Tinel Antoine; Lens Susanne; Steiner Quynh-Giao; Sauberli Estelle; Wilson Anne; Mackay Fabienne; Rolink Antonius G; Beermann Friedrich; Tschopp Jürg; Schneider Pascal
The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF.
European journal of immunology 2004;34(2):509-18.
2004: Batten Marcel; Fletcher Carrie; Ng Lai Guan; Groom Joanna; Wheway Julie; Laâbi Yacine; Xin Xiaoguan; Schneider Pascal; Tschopp Jurg; Mackay Charles R; Mackay Fabienne
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):812-22.
2003: Hiller Sebastian; Kohl Andreas; Fiorito Francesco; Herrmann Torsten; Wider Gerhard; Tschopp Jürg; Grütter Markus G; Wüthrich Kurt
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.
Structure (London, England : 1993) 2003;11(10):1199-205.
2003: Rothenberger Sylvia; Burns Kimberly; Rousseaux Marga; Tschopp Jürg; Bron Claude
Ubiquitination of the Epstein-Barr virus-encoded latent membrane protein 1 depends on the integrity of the TRAF binding site.
Oncogene 2003;22(36):5614-8.
2003: Thome Margot; Tschopp Jürg
TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1.
Trends in immunology 2003;24(8):419-24.
2003: Micheau Olivier; Tschopp Jürg
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.
Cell 2003;114(2):181-90.
2003: Schneider Pascal; Tschopp Jürg
BAFF and the regulation of B cell survival.
Immunology letters 2003;88(1):57-62.
2003: Legler Daniel F; Micheau Olivier; Doucey Marie-Agnès; Tschopp Jürg; Bron Claude
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation.
Immunity 2003;18(5):655-64.
2003: Viard-Leveugle Isabelle; Bullani Roberto R; Meda Paolo; Micheau Olivier; Limat Alain; Saurat Jean-Hilaire; Tschopp Jürg; French Lars E
Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions.
The Journal of biological chemistry 2003;278(18):16183-8.
2003: Tschopp Jürg; Martinon Fabio; Burns Kimberly
NALPs: a novel protein family involved in inflammation.
Nature reviews. Molecular cell biology 2003;4(2):95-104.
2003: Holler Nils; Tardivel Aubry; Kovacsovics-Bankowski Magdalena; Hertig Sylvie; Gaide Olivier; Martinon Fabio; Tinel Antoine; Deperthes David; Calderara Silvio; Schulthess Therese; Engel Jürgen; Schneider Pascal; Tschopp Jürg
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex.
Molecular and cellular biology 2003;23(4):1428-40.
2003: Burns Kimberly; Martinon Fabio; Tschopp Jürg
New insights into the mechanism of IL-1beta maturation.
Current opinion in immunology 2003;15(1):26-30.
2003: Schneider Pascal; Olson Dian; Tardivel Aubry; Browning Beth; Lugovskoy Alexey; Gong DaHai; Dobles Max; Hertig Sylvie; Hofmann Kay; Van Vlijmen Herman; Hsu Yen-Ming; Burkly Linda C; Tschopp Jurg; Zheng Timothy S
Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
The Journal of biological chemistry 2003;278(7):5444-54.
2003: French Lars E; Tschopp Jürg
Protein-based therapeutic approaches targeting death receptors.
Cell death and differentiation 2003;10(1):117-23.
2003: Burns Kimberly; Janssens Sophie; Brissoni Brian; Olivos Natalia; Beyaert Rudi; Tschopp Jürg
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.
The Journal of experimental medicine 2003;197(2):263-8.
2002: Meylan Etienne; Martinon Fabio; Thome Margot; Gschwendt Michael; Tschopp Jürg
RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.
EMBO reports 2002;3(12):1201-8.
2002: Micheau Olivier; Thome Margot; Schneider Pascal; Holler Nils; Tschopp Jürg; Nicholson Donald W; Briand Christophe; Grütter Markus G
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex.
The Journal of biological chemistry 2002;277(47):45162-71.
2002: Kaufmann Markus; Bozic Damir; Briand Christophe; Bodmer Jean-Luc; Zerbe Oliver; Kohl Andreas; Tschopp Jürg; Grütter Markus G
Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling.
FEBS letters 2002;527(1-3):250-4.
2002: Gaide Olivier; Favier Benoît; Legler Daniel F; Bonnet David; Brissoni Brian; Valitutti Salvatore; Bron Claude; Tschopp Jürg; Thome Margot
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation.
Nature immunology 2002;3(9):836-43.
2002: Martinon Fabio; Burns Kimberly; Tschopp Jürg
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
Molecular cell 2002;10(2):417-26.
2002: Lens Susanne M A; Kataoka Takao; Fortner Karen A; Tinel Antoine; Ferrero Isabel; MacDonald Robson H; Hahne Michel; Beermann Friedrich; Attinger Antoine; Orbea Hans-Acha; Budd Ralph C; Tschopp Jürg
The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes.
Molecular and cellular biology 2002;22(15):5419-33.
2002: Bullani R R; Wehrli P; Viard-Leveugle I; Rimoldi D; Cerottini J-C; Saurat J-H; Tschopp J; French L E
Frequent downregulation of Fas (CD95) expression and function in melanoma.
Melanoma research 2002;12(3):263-70.
2002: Kovacsovics Magdalena; Martinon Fabio; Micheau Olivier; Bodmer Jean Luc; Hofmann Kay; Tschopp Jürg
Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation.
Current biology : CB 2002;12(10):838-43.
2002: French Lars E; Tschopp Jürg
Defective death receptor signaling as a cause of tumor immune escape.
Seminars in cancer biology 2002;12(1):51-5.
2002: Bodmer Jean-Luc; Schneider Pascal; Tschopp Jürg
The molecular architecture of the TNF superfamily.
Trends in biochemical sciences 2002;27(1):19-26.
2002: Groom Joanna; Kalled Susan L; Cutler Anne H; Olson Carl; Woodcock Stephen A; Schneider Pascal; Tschopp Jurg; Cachero Teresa G; Batten Marcel; Wheway Julie; Mauri Davide; Cavill Dana; Gordon Tom P; Mackay Charles R; Mackay Fabienne
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome.
The Journal of clinical investigation 2002;109(1):59-68.
2001: Schneider P; Takatsuka H; Wilson A; Mackay F; Tardivel A; Lens S; Cachero T G; Finke D; Beermann F; Tschopp J
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen.
The Journal of experimental medicine 2001;194(11):1691-7.
2001: Huard B; Schneider P; Mauri D; Tschopp J; French L E
T cell costimulation by the TNF ligand BAFF.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6225-31.
2001: Thome M; Tschopp J
Regulation of lymphocyte proliferation and death by FLIP.
Nature reviews. Immunology 2001;1(1):50-8.
2001: Wehrli P; Charnay Y; Vallet P; Zhu G; Harmony J; Aronow B; Tschopp J; Bouras C; Viard-Leveugle I; French L E; Giannakopoulos P
Inhibition of post-ischemic brain injury by clusterin overexpression.
Nature medicine 2001;7(9):977-9.
2001: Thompson J S; Bixler S A; Qian F; Vora K; Scott M L; Cachero T G; Hession C; Schneider P; Sizing I D; Mullen C; Strauch K; Zafari M; Benjamin C D; Tschopp J; Browning J L; Ambrose C
BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.
Science (New York, N.Y.) 2001;293(5537):2108-11.
2001: Bullani R R; Huard B; Viard-Leveugle I; Byers H R; Irmler M; Saurat J H; Tschopp J; French L E
Selective expression of FLIP in malignant melanocytic skin lesions.
The Journal of investigative dermatology 2001;117(2):360-4.
2001: Micheau O; Lens S; Gaide O; Alevizopoulos K; Tschopp J
NF-kappaB signals induce the expression of c-FLIP.
Molecular and cellular biology 2001;21(16):5299-305.
2001: Siegmund D; Mauri D; Peters N; Juo P; Thome M; Reichwein M; Blenis J; Scheurich P; Tschopp J; Wajant H
Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway.
The Journal of biological chemistry 2001;276(35):32585-90.
2001: Schneider P; Street S L; Gaide O; Hertig S; Tardivel A; Tschopp J; Runkel L; Alevizopoulos K; Ferguson B M; Zonana J
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A.
The Journal of biological chemistry 2001;276(22):18819-27.
2001: Kataoka T; Holler N; Micheau O; Martinon F; Tinel A; Hofmann K; Tschopp J
Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension.
The Journal of biological chemistry 2001;276(22):19548-54.
2001: Gaide O; Martinon F; Micheau O; Bonnet D; Thome M; Tschopp J
Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.
FEBS letters 2001;496(2-3):121-7.
2001: Thome M; Gaide O; Micheau O; Martinon F; Bonnet D; Gonzalez M; Tschopp J
Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10.
The Journal of cell biology 2001;152(5):1115-22.
2001: Benedict C A; Norris P S; Prigozy T I; Bodmer J L; Mahr J A; Garnett C T; Martinon F; Tschopp J; Gooding L R; Ware C F
Three adenovirus E3 proteins cooperate to evade apoptosis by tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and -2.
The Journal of biological chemistry 2001;276(5):3270-8.
2001: Werner-Favre C; Bovia F; Schneider P; Holler N; Barnet M; Kindler V; Tschopp J; Zubler R H
IgG subclass switch capacity is low in switched and in IgM-only, but high in IgD+IgM+, post-germinal center (CD27+) human B cells.
European journal of immunology 2001;31(1):243-9.
2000: Schlapbach R; Spanaus K S; Malipiero U; Lens S; Tasinato A; Tschopp J; Fontana A
TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia.
European journal of immunology 2000;30(12):3680-8.
2000: Rennert P; Schneider P; Cachero T G; Thompson J; Trabach L; Hertig S; Holler N; Qian F; Mullen C; Strauch K; Browning J L; Ambrose C; Tschopp J
A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth.
The Journal of experimental medicine 2000;192(11):1677-84.
2000: Rescigno M; Piguet V; Valzasina B; Lens S; Zubler R; French L; Kindler V; Tschopp J; Ricciardi-Castagnoli P
Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses.
The Journal of experimental medicine 2000;192(11):1661-8.
2000: Holler N; Zaru R; Micheau O; Thome M; Attinger A; Valitutti S; Bodmer J L; Schneider P; Seed B; Tschopp J
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
Nature immunology 2000;1(6):489-95.
2000: French L E; Tschopp J
Fas-mediated cell death in toxic epidermal necrolysis and graft-versus-host disease: potential for therapeutic inhibition.
Schweizerische medizinische Wochenschrift 2000;130(44):1656-61.
2000: Batten M; Groom J; Cachero T G; Qian F; Schneider P; Tschopp J; Browning J L; Mackay F
BAFF mediates survival of peripheral immature B lymphocytes.
The Journal of experimental medicine 2000;192(10):1453-66.
2000: Tucker A S; Headon D J; Schneider P; Ferguson B M; Overbeek P; Tschopp J; Sharpe P T
Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis.
Development (Cambridge, England) 2000;127(21):4691-700.
2000: Rochat-Steiner V; Becker K; Micheau O; Schneider P; Burns K; Tschopp J
FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.
The Journal of experimental medicine 2000;192(8):1165-74.
2000: Mühlenbeck F; Schneider P; Bodmer J L; Schwenzer R; Hauser A; Schubert G; Scheurich P; Moosmayer D; Tschopp J; Wajant H
The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation.
The Journal of biological chemistry 2000;275(41):32208-13.
2000: Wehrli P; Viard I; Bullani R; Tschopp J; French L E
Death receptors in cutaneous biology and disease.
The Journal of investigative dermatology 2000;115(2):141-8.
2000: Villunger A; Huang D C; Holler N; Tschopp J; Strasser A
Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1337-43.
2000: Thompson J S; Schneider P; Kalled S L; Wang L; Lefevre E A; Cachero T G; MacKay F; Bixler S A; Zafari M; Liu Z Y; Woodcock S A; Qian F; Batten M; Madry C; Richard Y; Benjamin C D; Browning J L; Tsapis A; Tschopp J; Ambrose C
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.
The Journal of experimental medicine 2000;192(1):129-35.
2000: Bodmer J L; Meier P; Tschopp J; Schneider P
Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL.
The Journal of biological chemistry 2000;275(27):20632-7.
2000: Burns K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
Nature cell biology 2000;2(6):346-51.
2000: Kataoka T; Budd R C; Holler N; Thome M; Martinon F; Irmler M; Burns K; Hahne M; Kennedy N; Kovacsovics M; Tschopp J
The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways.
Current biology : CB 2000;10(11):640-8.
2000: Bodmer J L; Holler N; Reynard S; Vinciguerra P; Schneider P; Juo P; Blenis J; Tschopp J
TRAIL receptor-2 signals apoptosis through FADD and caspase-8.
Nature cell biology 2000;2(4):241-3.
2000: Holler N; Kataoka T; Bodmer J L; Romero P; Romero J; Deperthes D; Engel J; Tschopp J; Schneider P
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors.
Journal of immunological methods 2000;237(1-2):159-73.
2000: Martinon F; Holler N; Richard C; Tschopp J
Activation of a pro-apoptotic amplification loop through inhibition of NF-kappaB-dependent survival signals by caspase-mediated inactivation of RIP.
FEBS letters 2000;468(2-3):134-6.
2000: Irmler M; Steiner V; Ruegg C; Wajant H; Tschopp J
Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis.
FEBS letters 2000;468(2-3):129-33.
2000: Schneider P; Tschopp J
Modulation of death receptor signalling.
Symposia of the Society for Experimental Biology 2000;52():31-42.
1999: Huang D C; Hahne M; Schroeter M; Frei K; Fontana A; Villunger A; Newton K; Tschopp J; Strasser A
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L).
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14871-6.
1999: Kennedy N J; Kataoka T; Tschopp J; Budd R C
Caspase activation is required for T cell proliferation.
The Journal of experimental medicine 1999;190(12):1891-6.
1999: Mackay F; Woodcock S A; Lawton P; Ambrose C; Baetscher M; Schneider P; Tschopp J; Browning J L
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.
The Journal of experimental medicine 1999;190(11):1697-710.
1999: Malipiero U; Heuss C; Schlapbach R; Tschopp J; Gerber U; Fontana A
Involvement of the N-methyl-D-aspartate receptor in neuronal cell death induced by cytotoxic T cell-derived secretory granules.
European journal of immunology 1999;29(10):3053-62.
1999: French L E; Tschopp J
Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors.
The Journal of experimental medicine 1999;190(7):891-4.
1999: Schneider P; Schwenzer R; Haas E; Mühlenbeck F; Schubert G; Scheurich P; Tschopp J; Wajant H
TWEAK can induce cell death via endogenous TNF and TNF receptor 1.
European journal of immunology 1999;29(6):1785-92.
1999: Schneider P; MacKay F; Steiner V; Hofmann K; Bodmer J L; Holler N; Ambrose C; Lawton P; Bixler S; Acha-Orbea H; Valmori D; Romero P; Werner-Favre C; Zubler R H; Browning J L; Tschopp J
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
The Journal of experimental medicine 1999;189(11):1747-56.
1999: Tschopp J; Martinon F; Hofmann K
Apoptosis: Silencing the death receptors.
Current biology : CB 1999;9(10):R381-4.
1999: Thome M; Martinon F; Hofmann K; Rubio V; Steiner V; Schneider P; Mattmann C; Tschopp J
Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.
The Journal of biological chemistry 1999;274(15):9962-8.
1999: Viard I; Wehrli P; Jornot L; Bullani R; Vechietti J L; Schifferli J A; Tschopp J; French L E
Clusterin gene expression mediates resistance to apoptotic cell death induced by heat shock and oxidative stress.
The Journal of investigative dermatology 1999;112(3):290-6.
1998: Kessler B; Hudrisier D; Schroeter M; Tschopp J; Cerottini J C; Luescher I F
Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6939-46.
1998: Tschopp J; Irmler M; Thome M
Inhibition of fas death signals by FLIPs.
Current opinion in immunology 1998;10(5):552-8.
1998: Kataoka T; Schröter M; Hahne M; Schneider P; Irmler M; Thome M; Froelich C J; Tschopp J
FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3936-42.
1998: Viard I; Wehrli P; Bullani R; Schneider P; Holler N; Salomon D; Hunziker T; Saurat J H; Tschopp J; French L E
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
Science (New York, N.Y.) 1998;282(5388):490-3.
1998: Hahne M; Kataoka T; Schröter M; Hofmann K; Irmler M; Bodmer J L; Schneider P; Bornand T; Holler N; French L E; Sordat B; Rimoldi D; Tschopp J
APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
The Journal of experimental medicine 1998;188(6):1185-90.
1998: Jaunin F; Burns K; Tschopp J; Martin T E; Fakan S
Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells.
Experimental cell research 1998;243(1):67-75.
1998: Thome M; Hofmann K; Burns K; Martinon F; Bodmer J L; Mattmann C; Tschopp J
Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
Current biology : CB 1998;8(15):885-8.
1998: Burns K; Martinon F; Esslinger C; Pahl H; Schneider P; Bodmer J L; Di Marco F; French L; Tschopp J
MyD88, an adapter protein involved in interleukin-1 signaling.
The Journal of biological chemistry 1998;273(20):12203-9.
1998: Schneider P; Holler N; Bodmer J L; Hahne M; Frei K; Fontana A; Tschopp J
Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity.
The Journal of experimental medicine 1998;187(8):1205-13.
1998: Renno T; Attinger A; Rimoldi D; Hahne M; Tschopp J; MacDonald H R
Expression of B220 on activated T cell blasts precedes apoptosis.
European journal of immunology 1998;28(2):540-7.
1998: Conceição-Silva F; Hahne M; Schröter M; Louis J; Tschopp J
The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity.
European journal of immunology 1998;28(1):237-45.
1997: Malipiero U; Frei K; Spanaus K S; Agresti C; Lassmann H; Hahne M; Tschopp J; Eugster H P; Fontana A
Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice.
European journal of immunology 1997;27(12):3151-60.
1997: Schneider P; Thome M; Burns K; Bodmer J L; Hofmann K; Kataoka T; Holler N; Tschopp J
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
Immunity 1997;7(6):831-6.
1997: Schneider P; Bodmer J L; Thome M; Hofmann K; Holler N; Tschopp J
Characterization of two receptors for TRAIL.
FEBS letters 1997;416(3):329-34.
1997: French L E; Wilson A; Hahne M; Viard I; Tschopp J; MacDonald H R
Fas ligand expression is restricted to nonlymphoid thymic components in situ.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2196-202.
1997: Becker K; Schneider P; Hofmann K; Mattmann C; Tschopp J
Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathway.
FEBS letters 1997;412(1):102-6.
1997: Schneider P; Bodmer J L; Holler N; Mattmann C; Scuderi P; Terskikh A; Peitsch M C; Tschopp J
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction.
The Journal of biological chemistry 1997;272(30):18827-33.
1997: Irmler M; Thome M; Hahne M; Schneider P; Hofmann K; Steiner V; Bodmer J L; Schröter M; Burns K; Mattmann C; Rimoldi D; French L E; Tschopp J
Inhibition of death receptor signals by cellular FLIP.
Nature 1997;388(6638):190-5.
1997: Hofmann K; Bucher P; Tschopp J
The CARD domain: a new apoptotic signalling motif.
Trends in biochemical sciences 1997;22(5):155-6.
1997: Irmler M; Hofmann K; Vaux D; Tschopp J
Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4.
FEBS letters 1997;406(1-2):189-90.
1997: Thome M; Schneider P; Hofmann K; Fickenscher H; Meinl E; Neipel F; Mattmann C; Burns K; Bodmer J L; Schröter M; Scaffidi C; Krammer P H; Peter M E; Tschopp J
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors.
Nature 1997;386(6624):517-21.
1997: Renggli J; Hahne M; Matile H; Betschart B; Tschopp J; Corradin G
Elimination of P. berghei liver stages is independent of Fas (CD95/Apo-I) or perforin-mediated cytotoxicity.
Parasite immunology 1997;19(3):145-8.
1997: Bodmer J L; Burns K; Schneider P; Hofmann K; Steiner V; Thome M; Bornand T; Hahne M; Schröter M; Becker K; Wilson A; French L E; Browning J L; MacDonald H R; Tschopp J
TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).
Immunity 1997;6(1):79-88.
1997: Cerottini J C; Tschopp J
New knowledge about T-cell cytotoxicity.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1997;8 Suppl 2():75-8.
1996: Hahne M; Rimoldi D; Schröter M; Romero P; Schreier M; French L E; Schneider P; Bornand T; Fontana A; Lienard D; Cerottini J; Tschopp J
Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape.
Science (New York, N.Y.) 1996;274(5291):1363-6.
1996: Lowin B; French L; Martinou J C; Tschopp J
Expression of the CTL-associated protein TIA-1 during murine embryogenesis.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1448-54.
1996: Sadoul R; Fernandez P A; Quiquerez A L; Martinou I; Maki M; Schröter M; Becherer J D; Irmler M; Tschopp J; Martinou J C
Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.
The EMBO journal 1996;15(15):3845-52.
1996: French L E; Hahne M; Viard I; Radlgruber G; Zanone R; Becker K; Müller C; Tschopp J
Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.
The Journal of cell biology 1996;133(2):335-43.
1996: Hahne M; Renno T; Schroeter M; Irmler M; French L; Bornard T; MacDonald H R; Tschopp J
Activated B cells express functional Fas ligand.
European journal of immunology 1996;26(3):721-4.
1996: Schroter M; Peitsch M C; Tschopp J
Increased p34cdc2-dependent kinase activity during apoptosis: a possible activation mechanism of DNase I leading to DNA breakdown.
European journal of cell biology 1996;69(2):143-50.
1996: Braun M Y; Lowin B; French L; Acha-Orbea H; Tschopp J
Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.
The Journal of experimental medicine 1996;183(2):657-61.
1996: Renno T; Hahne M; Tschopp J; MacDonald H R
Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand.
The Journal of experimental medicine 1996;183(2):431-7.
1996: Lowin B; Mattman C; Hahne M; Tschopp J
Comparison of Fas(Apo-1/CD95)- and perforin-mediated cytotoxicity in primary T lymphocytes.
International immunology 1996;8(1):57-63.
1995: Schröter M; Lowin B; Borner C; Tschopp J
Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2.
European journal of immunology 1995;25(12):3509-13.
1995: Hane M; Lowin B; Peitsch M; Becker K; Tschopp J
Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain.
FEBS letters 1995;373(3):265-8.
1995: Hofmann K; Tschopp J
The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance.
FEBS letters 1995;371(3):321-3.
1995: Hahne M; Peitsch M C; Irmler M; Schröter M; Lowin B; Rousseau M; Bron C; Renno T; French L; Tschopp J
Characterization of the non-functional Fas ligand of gld mice.
International immunology 1995;7(9):1381-6.
1995: Irmler M; Hertig S; MacDonald H R; Sadoul R; Becherer J D; Proudfoot A; Solari R; Tschopp J
Granzyme A is an interleukin 1 beta-converting enzyme.
The Journal of experimental medicine 1995;181(5):1917-22.
1995: Peitsch M C; Irmler M; French L E; Tschopp J
Genomic organisation and expression of mouse deoxyribonuclease I.
Biochemical and biophysical research communications 1995;207(1):62-8.
1995: Lowin B; Peitsch M C; Tschopp J
Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity.
Current topics in microbiology and immunology 1995;198():1-24.
1994: Lowin B; Beermann F; Schmidt A; Tschopp J
A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11571-5.
1994: Borner C; Olivier R; Martinou I; Mattmann C; Tschopp J; Martinou J C
Dissection of functional domains in Bcl-2 alpha by site-directed mutagenesis.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1994;72(11-12):463-9.
1994: Müller C; Tschopp J
Resistance of CTL to perforin-mediated lysis. Evidence for a lymphocyte membrane protein interacting with perforin.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2470-8.
1994: Albrecht H; Tschopp J; Jongeneel C V
Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-kappa B by TNF.
FEBS letters 1994;351(1):45-8.
1994: Tschopp J; French L E
Clusterin: modulation of complement function.
Clinical and experimental immunology 1994;97 Suppl 2():11-4.
1994: Borner C; Martinou I; Mattmann C; Irmler M; Schaerer E; Martinou J C; Tschopp J
The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.
The Journal of cell biology 1994;126(4):1059-68.
1994: Lowin B; Hahne M; Mattmann C; Tschopp J
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways.
Nature 1994;370(6491):650-2.
1994: Polzar B; Zanotti S; Stephan H; Rauch F; Peitsch M C; Irmler M; Tschopp J; Mannherz H G
Distribution of deoxyribonuclease I in rat tissues and its correlation to cellular turnover and apoptosis (programmed cell death).
European journal of cell biology 1994;64(1):200-10.
1994: French L E; Wohlwend A; Sappino A P; Tschopp J; Schifferli J A
Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death.
The Journal of clinical investigation 1994;93(2):877-84.
1994: Peitsch M C; Tschopp J
Granzyme B.
Methods in enzymology 1994;244():80-7.
1993: Polzar B; Peitsch M C; Loos R; Tschopp J; Mannherz H G
Overexpression of deoxyribonuclease I (DNase I) transfected into COS-cells: its distribution during apoptotic cell death.
European journal of cell biology 1993;62(2):397-405.
1993: French L E; Chonn A; Ducrest D; Baumann B; Belin D; Wohlwend A; Kiss J Z; Sappino A P; Tschopp J; Schifferli J A
Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis.
The Journal of cell biology 1993;122(5):1119-30.
1993: Tschopp J; Chonn A; Hertig S; French L E
Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(4):2159-65.
1993: Peitsch M C; Borner C; Tschopp J
Sequence similarity of phospholipase A2 activating protein and the G protein beta-subunits: a new concept of effector protein activation in signal transduction?
Trends in biochemical sciences 1993;18(8):292-3.
1993: Tschopp J; Jenne D E; Hertig S; Preissner K T; Morgenstern H; Sapino A P; French L
Human megakaryocytes express clusterin and package it without apolipoprotein A-1 into alpha-granules.
Blood 1993;82(1):118-25.
1993: Schaerer E; Tschopp J
Cytotoxic mechanisms: cytolytic T cells keep their secrets.
Current biology : CB 1993;3(3):167-9.
1993: Peitsch M C; Polzar B; Stephan H; Crompton T; MacDonald H R; Mannherz H G; Tschopp J
Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).
The EMBO journal 1993;12(1):371-7.
1993: Dupuis M; Schaerer E; Krause K H; Tschopp J
The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.
The Journal of experimental medicine 1993;177(1):1-7.
1993: Dupuis M; Peitsch M C; Hamann U; Stanley K K; Tschopp J
Mutations in the putative lipid-interaction domain of complement C9 result in defective secretion of the functional protein.
Molecular immunology 1993;30(1):95-100.
1992: Lowin B; Krähenbühl O; Müller C; Dupuis M; Tschopp J
Perforin and its role in T lymphocyte-mediated cytolysis.
Experientia 1992;48(10):911-20.
1992: Peitsch M C; Hesterkamp T; Polzar B; Mannherz H G; Tschopp J
Functional characterisation of serum DNase I in MRL-lpr/lpr mice.
Biochemical and biophysical research communications 1992;186(2):739-45.
1992: Jenne D E; Tschopp J
Clusterin: the intriguing guises of a widely expressed glycoprotein.
Trends in biochemical sciences 1992;17(4):154-9.
1992: Krähenbühl O; Gattesco S; Tschopp J
Murine Thy-1+ dendritic epidermal T cell lines express granule-associated perforin and a family of granzyme molecules.
Immunobiology 1992;184(4-5):392-401.
1992: Crompton T; Peitsch M C; MacDonald H R; Tschopp J
Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei.
Biochemical and biophysical research communications 1992;183(2):532-7.
1991: Krähenbühl O; Tschopp J
Debate: the mechanism of lymphocyte-mediated killing. Perforin-induced pore formation.
Immunology today 1991;12(11):399-402; discussion 403.
1991: Jenne D E; Zimmer M; Garcia-Sanz J A; Tschopp J; Lichter P
Genomic organization and subchromosomal in situ localization of the murine granzyme F, a serine protease expressed in CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):1045-52.
1991: Peitsch M C; Tschopp J
Assembly of macromolecular pores by immune defense systems.
Current opinion in cell biology 1991;3(4):710-6.
1991: Jenne D E; Lowin B; Peitsch M C; Böttcher A; Schmitz G; Tschopp J
Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma.
The Journal of biological chemistry 1991;266(17):11030-6.
1991: Haefliger J A; Peitsch M C; Jenne D E; Tschopp J
Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family.
Molecular immunology 1991;28(1-2):123-31.
1990: Acha-Orbea H; Scarpellino L; Hertig S; Dupuis M; Tschopp J
Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides.
The EMBO journal 1990;9(12):3815-9.
1990: Masson D; Peters P J; Geuze H J; Borst J; Tschopp J
Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH.
Biochemistry 1990;29(51):11229-35.
1990: Garcia-Sanz J A; MacDonald H R; Jenne D E; Tschopp J; Nabholz M
Cell specificity of granzyme gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(9):3111-8.
1990: Krähenbühl O; Tschopp J
Involvement of granule proteins in T-cell-mediated cytolysis.
Natural immunity and cell growth regulation 1990;9(4):274-82.
1990: Tschopp J; Nabholz M
Perforin-mediated target cell lysis by cytolytic T lymphocytes.
Annual review of immunology 1990;8():279-302.
1989: Haefliger J A; Tschopp J; Vial N; Jenne D E
Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.
The Journal of biological chemistry 1989;264(30):18041-51.
1989: Jenne D E; Tschopp J
Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7123-7.
1989: Jenne D E; Masson D; Zimmer M; Haefliger J A; Li W H; Tschopp J
Isolation and complete structure of the lymphocyte serine protease granzyme G, a novel member of the granzyme multigene family in murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte proteases.
Biochemistry 1989;28(19):7953-61.
1989: Nabholz M; Tschopp J
CTL-mediated cytolysis: perforin and alternative pathways?
Immunology letters 1989;20(3):179-80.
1989: Krähenbühl O P; Peter H H; Tschopp J
Absence of homologous restriction factor does not affect CTL-mediated cytolysis.
European journal of immunology 1989;19(1):217-9.
1989: Tschopp J; Schäfer S; Masson D; Peitsch M C; Heusser C
Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin.
Nature 1989;337(6204):272-4.
1988: Masson D; Tschopp J
Inhibition of lymphocyte protease granzyme A by antithrombin III.
Molecular immunology 1988;25(12):1283-9.
1988: Krähenbühl O; Rey C; Jenne D; Lanzavecchia A; Groscurth P; Carrel S; Tschopp J
Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3471-7.
1988: Gromkowski S H; Brown T C; Masson D; Tschopp J
Lack of DNA degradation in target cells lysed by granules derived from cytolytic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):774-8.
1988: Jenne D; Rey C; Haefliger J A; Qiao B Y; Groscurth P; Tschopp J
Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4814-8.
1988: Garcia-Sanz J A; Velotti F; MacDonald H R; Masson D; Tschopp J; Nabholz M
Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli.
Immunology 1988;64(1):129-34.
1988: Tschopp J; Masson D; Schäfer S; Peitsch M; Preissner K T
The heparin binding domain of S-protein/vitronectin binds to complement components C7, C8, and C9 and perforin from cytolytic T-cells and inhibits their lytic activities.
Biochemistry 1988;27(11):4103-9.
1988: Tschopp J; Jongeneel C V
Cytotoxic T lymphocyte mediated cytolysis.
Biochemistry 1988;27(8):2641-6.
1988: Jenne D E; Tschopp J
Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation.
Immunological reviews 1988;103():53-71.
1988: Peitsch M C; Tschopp J; Kress A; Isliker H
Antibody-independent activation of the complement system by mitochondria is mediated by cardiolipin.
The Biochemical journal 1988;249(2):495-500.
1988: Jenne D; Rey C; Masson D; Stanley K K; Herz J; Plaetinck G; Tschopp J
cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(1):318-23.
1987: Haefliger J A; Jenne D; Stanley K K; Tschopp J
Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern.
Biochemical and biophysical research communications 1987;149(2):750-4.
1987: Tschopp J; Masson D
Inhibition of the lytic activity of perforin (cytolysin) and of late complement components by proteoglycans.
Molecular immunology 1987;24(9):907-13.
1987: Haefliger J A; Tschopp J; Nardelli D; Wahli W; Kocher H P; Tosi M; Stanley K K
Complementary DNA cloning of complement C8 beta and its sequence homology to C9.
Biochemistry 1987;26(12):3551-6.
1987: Garcia-Sanz J A; Plaetinck G; Velotti F; Masson D; Tschopp J; MacDonald H R; Nabholz M
Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets.
The EMBO journal 1987;6(4):933-8.
1987: Peitsch M C; Kovacsovics T J; Tschopp J; Isliker H
Antibody-independent activation of C1. II. Evidence for two classes of nonimmune activators of the classical pathway of complement.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1871-6.
1986: Tschopp J; Masson D; Stanley K K
Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis.
Nature 1986;322(6082):831-4.
1986: Masson D; Nabholz M; Estrade C; Tschopp J
Granules of cytolytic T-lymphocytes contain two serine esterases.
The EMBO journal 1986;5(7):1595-600.
1985: Kovacsovics T; Tschopp J; Kress A; Isliker H
Antibody-independent activation of C1, the first component of complement, by cardiolipin.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(4):2695-700.
1985: Masson D; Corthésy P; Nabholz M; Tschopp J
Appearance of cytolytic granules upon induction of cytolytic activity in CTL-hybrids.
The EMBO journal 1985;4(10):2533-8.
1985: Stanley K K; Kocher H P; Luzio J P; Jackson P; Tschopp J
The sequence and topology of human complement component C9.
The EMBO journal 1985;4(2):375-82.

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