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Yuk-Ching Tse-Dinh

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Bokun Cheng; Jon Clardy; Giselle Tamayo; Thirunavukkarasu Annamalai; Shugeng Cao; Victor Vasquez; Yuk-Ching Tse-Dinh
Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor.
Sandhya Bansal; Bokun Cheng; Manish Singh; Devapriya Sinha; Yuk-Ching Tse-Dinh; Vibha Tandon
3,4-dimethoxyphenyl bis-benzimidazole, a novel DNA topoisomerase inhibitor that preferentially targets Escherichia coli topoisomerase I.
Sandra Aedo; Yuk-Ching Tse-Dinh
Isolation and quantitation of topoisomerase complexes accumulated on Escherichia coli chromosomal DNA.

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2013: Bokun Cheng; Jon Clardy; Giselle Tamayo; Thirunavukkarasu Annamalai; Shugeng Cao; Victor Vasquez; Yuk-Ching Tse-Dinh
Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor.
PloS one 2013;8(4):e60770.
2012: Sandhya Bansal; Bokun Cheng; Manish Singh; Devapriya Sinha; Yuk-Ching Tse-Dinh; Vibha Tandon
3,4-dimethoxyphenyl bis-benzimidazole, a novel DNA topoisomerase inhibitor that preferentially targets Escherichia coli topoisomerase I.
The Journal of antimicrobial chemotherapy 2012;67(12):2882-91.
2012: Sandra Aedo; Yuk-Ching Tse-Dinh
Isolation and quantitation of topoisomerase complexes accumulated on Escherichia coli chromosomal DNA.
Antimicrobial agents and chemotherapy 2012;56(11):5458-64.
2012: Gagandeep Narula; Yuk-Ching Tse-Dinh
Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage.
Nucleic acids research 2012;40(18):9233-43.
2011: Laura Casu; Filippo Cottiglia; Alessandro De Logu; Marco Leonti; Valentina Lombardo; Emanuela Agus; Yuk-Ching Tse-Dinh; Claudia Sissi
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.
Bioorganic & medicinal chemistry letters 2011;21(23):7041-4.
2011: I-Fen Liu; Jeanette H Sutherland; Bokun Cheng; Yuk-Ching Tse-Dinh
Topoisomerase I function during Escherichia coli response to antibiotics and stress enhances cell killing from stabilization of its cleavage complex.
The Journal of antimicrobial chemotherapy 2011;66(7):1518-24.
2011: Gagandeep Narula; Thirunavukkarasu Annamalai; Sandra Aedo; Bokun Cheng; Elena Sorokin; Agnes Wong; Yuk-Ching Tse-Dinh
The strictly conserved Arg-321 residue in the active site of Escherichia coli topoisomerase I plays a critical role in DNA rejoining.
The Journal of biological chemistry 2011;286(21):18673-80.
2011: Zhongtao Zhang; Bokun Cheng; Yuk-Ching Tse-Dinh
Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6939-44.
2011: I-Fen Liu; Sandra Aedo; Yuk-Ching Tse-Dinh
Resistance to topoisomerase cleavage complex induced lethality in Escherichia coli via titration of transcription regulators PurR and FNR.
BMC microbiology 2011;11():261.
2010: Jeanette H Sutherland; Yuk-Ching Tse-Dinh
Analysis of RuvABC and RecG involvement in the escherichia coli response to the covalent topoisomerase-DNA complex.
Journal of bacteriology 2010;192(17):4445-51.
2010: Gagandeep Narula; Jennifer Becker; Bokun Cheng; Neil Dani; Maria V Abrenica; Yuk-Ching Tse-Dinh
The DNA relaxation activity and covalent complex accumulation of Mycobacterium tuberculosis topoisomerase I can be assayed in Escherichia coli: application for identification of potential FRET-dye labeling sites.
BMC biochemistry 2010;11():41.
2009: I-Fen Liu; Thirunavukkarasu Annamalai; Jeanette H Sutherland; Yuk-Ching Tse-Dinh
Hydroxyl radicals are involved in cell killing by the bacterial topoisomerase I cleavage complex.
Journal of bacteriology 2009;191(16):5315-9.
2009: Yuk-Ching Tse-Dinh
Bacterial topoisomerase I as a target for discovery of antibacterial compounds.
Nucleic acids research 2009;37(3):731-7.
2009: Bokun Cheng; Thirunavukkarasu Annamalai; Elena Sorokin; Maria Abrenica; Sandra Aedo; Yuk-Ching Tse-Dinh
Asp-to-Asn substitution at the first position of the DxD TOPRIM motif of recombinant bacterial topoisomerase I is extremely lethal to E. coli.
Journal of molecular biology 2009;385(2):558-67.
2009: Thirunavukkarasu Annamalai; Neil Dani; Bokun Cheng; Yuk-Ching Tse-Dinh
Analysis of DNA relaxation and cleavage activities of recombinant Mycobacterium tuberculosis DNA topoisomerase I from a new expression and purification protocol.
BMC biochemistry 2009;10():18.
2008: Yuk-Ching Tse-Dinh
An update on the development of drugs against smallpox.
Current opinion in investigational drugs (London, England : 2000) 2008;9(8):865-70.
2008: Elena P Sorokin; Bokun Cheng; Siddarth Rathi; Sandra J Aedo; Maria V Abrenica; Yuk-Ching Tse-Dinh
Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region.
Nucleic acids research 2008;36(14):4788-96.
2008: Jeanette H Sutherland; Bokun Cheng; I-Fen Liu; Yuk-Ching Tse-Dinh
SOS induction by stabilized topoisomerase IA cleavage complex occurs via the RecBCD pathway.
Journal of bacteriology 2008;190(9):3399-403.
2008: Bokun Cheng; Elena P Sorokin; Yuk-Ching Tse-Dinh
Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.
Nucleic acids research 2008;36(3):1017-25.
2007: Bokun Cheng; I-Fen Liu; Yuk-Ching Tse-Dinh
Compounds with antibacterial activity that enhance DNA cleavage by bacterial DNA topoisomerase I.
The Journal of antimicrobial chemotherapy 2007;59(4):640-5.
2007: Yuk-Ching Tse-Dinh
Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases.
Infectious disorders drug targets 2007;7(1):3-9.
2006: Giuseppe Lia; Elise Praly; Helder Ferreira; Chris Stockdale; Yuk-Ching Tse-Dinh; David Dunlap; Vincent Croquette; David Bensimon; Tom Owen-Hughes
Direct observation of DNA distortion by the RSC complex.
Molecular cell 2006;21(3):417-25.
2006: Daniel Strahs; Chang-Xi Zhu; Bokun Cheng; Jason Chen; Yuk-Ching Tse-Dinh
Experimental and computational investigations of Ser10 and Lys13 in the binding and cleavage of DNA substrates by Escherichia coli DNA topoisomerase I.
Nucleic acids research 2006;34(6):1785-97.
2005: Bokun Cheng; Shikha Shukla; Sarinnapha Vasunilashorn; Somshuvra Mukhopadhyay; Yuk-Ching Tse-Dinh
Bacterial cell killing mediated by topoisomerase I DNA cleavage activity.
The Journal of biological chemistry 2005;280(46):38489-95.
2005: Natalee Stewart; Jingyang Feng; Xiaoping Liu; Devyani Chaudhuri; John W Foster; Marc Drolet; Yuk-Ching Tse-Dinh
Loss of topoisomerase I function affects the RpoS-dependent and GAD systems of acid resistance in Escherichia coli.
Microbiology (Reading, England) 2005;151(Pt 8):2783-91.
2004: Imad Baaklini; Chadi Hraiky; Fabien Rallu; Yuk-Ching Tse-Dinh; Marc Drolet
RNase HI overproduction is required for efficient full-length RNA synthesis in the absence of topoisomerase I in Escherichia coli.
Molecular microbiology 2004;54(1):198-211.
2004: Bokun Cheng; Jingyang Feng; Vishwaroop Mulay; Sharvari Gadgil; Yuk-Ching Tse-Dinh
Site-directed mutagenesis of residues involved in G Strand DNA binding by Escherichia coli DNA topoisomerase I.
The Journal of biological chemistry 2004;279(38):39207-13.
2004: Bokun Cheng; Jingyang Feng; Sharvari Gadgil; Yuk-Ching Tse-Dinh
Flexibility at Gly-194 is required for DNA cleavage and relaxation activity of Escherichia coli DNA topoisomerase I.
The Journal of biological chemistry 2004;279(10):8648-54.
2003: Bokun Cheng; Chang-Xi Zhu; Chengling Ji; Adriana Ahumada; Yuk-Ching Tse-Dinh
Direct interaction between Escherichia coli RNA polymerase and the zinc ribbon domains of DNA topoisomerase I.
The Journal of biological chemistry 2003;278(33):30705-10.
2003: Bokun Cheng; Shan Rui; Chengling Ji; Vivien W Gong; Tina K Van Dyk; Marc Drolet; Yuk-Ching Tse-Dinh
RNase H overproduction allows the expression of stress-induced genes in the absence of topoisomerase I.
FEMS microbiology letters 2003;221(2):237-42.
2003: Shan Rui; Yuk-Ching Tse-Dinh
Topoisomerase function during bacterial responses to environmental challenge.
Frontiers in bioscience : a journal and virtual library 2003;8():d256-63.
2002: Adriana Ahumada; Yuk-Ching Tse-Dinh
The role of the Zn(II) binding domain in the mechanism of E. coli DNA topoisomerase I.
BMC biochemistry 2002;3():13.
2001: Camille Roche; Yuk-Ching Tse-Dinh
Effect of phosphorothioate substitutions on DNA cleavage by Escherichia coli DNA topoisomerase I.
International journal of biological macromolecules 2001;29(3):175-80.
2001: Ram Kancherla; JS Nair; Tauseef Ahmed; H Durrani; Karen Seiter; A Mannancheril; Yuk-Ching Tse-Dinh
Evaluation of topotecan and etoposide for non-Hodgkin lymphoma: correlation of topoisomerase-DNA complex formation with clinical response.
Cancer 2001;91(3):463-71.
2000: JS Nair; Frank Traganos; Yuk-Ching Tse-Dinh
Differential effect of camptothecin treatment on topoisomerase II alpha expression in ML-1 and HL-60 leukemia cell lines.
Anticancer research 2000;20(6B):4183-8.
2000: C W Lin; Zbigniew Darzynkiewicz; Xuguang Li; Frank Traganos; Elzbieta Bedner; Yuk-Ching Tse-Dinh
Differential expression of human topoisomerase IIIalpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes.
Experimental cell research 2000;256(1):225-36.
2000: Chang-Xi Zhu; Yuk-Ching Tse-Dinh
The acidic triad conserved in type IA DNA topoisomerases is required for binding of Mg(II) and subsequent conformational change.
The Journal of biological chemistry 2000;275(8):5318-22.
2000: Yuk-Ching Tse-Dinh
Increased sensitivity to oxidative challenges associated with topA deletion in Escherichia coli.
Journal of bacteriology 2000;182(3):829-32.
2000: JS Nair; Ram Kancherla; Karen Seiter; Frank Traganos; Yuk-Ching Tse-Dinh
Action of topoisomerase targeting drugs on non-Hodgkin's lymphoma and leukemia. Correlation of clinical and cell culture studies.
Annals of the New York Academy of Sciences 2000;922():326-9.
1999: H Qi; R Menzel; Yuk-Ching Tse-Dinh
Increased thermosensitivity associated with topoisomerase I deletion and promoter mutations in Escherichia coli.
FEMS microbiology letters 1999;178(1):141-6.
1999: Chang-Xi Zhu; Yuk-Ching Tse-Dinh
Overexpression and purification of bacterial DNA topoisomerase I.
Methods in molecular biology (Clifton, N.J.) 1999;94():145-51.
1998: Adriana Ahumada; Yuk-Ching Tse-Dinh
The Zn(II) binding motifs of E. coli DNA topoisomerase I is part of a high-affinity DNA binding domain.
Biochemical and biophysical research communications 1998;251(2):509-14.
1998: Yuk-Ching Tse-Dinh
Bacterial and archeal type I topoisomerases.
Biochimica et biophysica acta 1998;1400(1-3):19-27.
1998: Chang-Xi Zhu; Camille Roche; N Papanicolaou; AM DiPietrantonio; Yuk-Ching Tse-Dinh
Site-directed mutagenesis of conserved aspartates, glutamates and arginines in the active site region of Escherichia coli DNA topoisomerase I.
The Journal of biological chemistry 1998;273(15):8783-9.
1997: Yuk-Ching Tse-Dinh; H Qi; R Menzel
DNA supercoiling and bacterial adaptation: thermotolerance and thermoresistance.
Trends in microbiology 1997;5(8):323-6.
1997: Chang-Xi Zhu; Camille Roche; Yuk-Ching Tse-Dinh
Effect of Mg(II) binding on the structure and activity of Escherichia coli DNA topoisomerase I.
The Journal of biological chemistry 1997;272(26):16206-10.
1997: H Qi; R Menzel; Yuk-Ching Tse-Dinh
Regulation of Escherichia coli topA gene transcription: involvement of a sigmaS-dependent promoter.
Journal of molecular biology 1997;267(3):481-9.
1996: H Qi; R Menzel; Yuk-Ching Tse-Dinh
Effect of the deletion of the sigma 32-dependent promoter (P1) of the Escherichia coli topoisomerase I gene on thermotolerance.
Molecular microbiology 1996;21(4):703-11.
1996: L Yu; Chang-Xi Zhu; Yuk-Ching Tse-Dinh; Stephen W Fesik
Backbone dynamics of the C-terminal domain of Escherichia coli topoisomerase I in the absence and presence of single-stranded DNA.
Biochemistry 1996;35(30):9661-6.
1996: M E Fernandez-Beros; Yuk-Ching Tse-Dinh
Vaccinia virus DNA topoisomerase I preferentially removes positive supercoils from DNA.
FEBS letters 1996;384(3):265-8.
1995: Chang-Xi Zhu; H Y Qi; Yuk-Ching Tse-Dinh
Mutation in Cys662 of Escherichia coli DNA topoisomerase I confers temperature sensitivity and change in DNA cleavage selectivity.
Journal of molecular biology 1995;250(5):609-16.
1995: L Yu; Chang-Xi Zhu; Yuk-Ching Tse-Dinh; Stephen W Fesik
Solution structure of the C-terminal single-stranded DNA-binding domain of Escherichia coli topoisomerase I.
Biochemistry 1995;34(23):7622-8.
1995: Chang-Xi Zhu; M Samuel; A Pound; A Ahumada; Yuk-Ching Tse-Dinh
Expression and DNA-binding properties of the 14K carboxyl terminal fragment of Escherichia coli DNA topoisomerase I.
Biochemistry and molecular biology international 1995;35(2):375-85.
1994: Chang-Xi Zhu; Yuk-Ching Tse-Dinh
Binding of Zn(II) to Escherichia coli DNA topoisomerase I.
Biochemistry and molecular biology international 1994;33(1):195-204.
1994: M Gupta; Chang-Xi Zhu; Yuk-Ching Tse-Dinh
Mutations of vaccinia virus DNA topoisomerase I that stabilize the cleavage complex.
The Journal of biological chemistry 1994;269(1):573-8.
1994: Yuk-Ching Tse-Dinh
Biochemistry of bacterial type I DNA topoisomerases.
Advances in pharmacology (San Diego, Calif.) 1994;29A():21-37.
1993: M Samuel; Chang-Xi Zhu; G B Villanueva; Yuk-Ching Tse-Dinh
Effect of zinc removal on the conformation of Escherichia coli DNA topoisomerase I.
Archives of biochemistry and biophysics 1993;300(1):302-8.
1992: M Gupta; Chang-Xi Zhu; Yuk-Ching Tse-Dinh
An engineered mutant of vaccinia virus DNA topoisomerase I is sensitive to the anti-cancer drug camptothecin.
The Journal of biological chemistry 1992;267(34):24177-80.
1992: M E Fernandez-Beros; Yuk-Ching Tse-Dinh
Conditional growth of Escherichia coli caused by expression of vaccinia virus DNA topoisomerase I.
Journal of bacteriology 1992;174(21):7059-62.
1991: Yuk-Ching Tse-Dinh
Zinc (II) coordination in Escherichia coli DNA topoisomerase I is required for cleavable complex formation with DNA.
The Journal of biological chemistry 1991;266(22):14317-20.