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Roger Tsien

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TOP 3
Roy Weinstain; Michael E Baker; Lesley G Ellies; Beth Friedman; Joan Kanter; Roger Y Tsien
Fluorescent ligand for human progesterone receptor imaging in live cells.
Eilon Shani; Roger Y Tsien; Roy Weinstain; Yi Zhang; Cristina Castillejo; joanne chory; Eirini Kaiserli; SD MA
Gibberellins accumulate in the elongating endodermal cells of Arabidopsis root.
Margaret T Butko; Claire Delahunty; Ford Ebner; Beth Friedman; Jeffrey N Savas; John R Yates; Roger Y Tsien
In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation.

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2013: Roy Weinstain; Michael E Baker; Lesley G Ellies; Beth Friedman; Joan Kanter; Roger Y Tsien
Fluorescent ligand for human progesterone receptor imaging in live cells.
Bioconjugate chemistry 2013;24(5):766-71.
2013: Eilon Shani; Roger Y Tsien; Roy Weinstain; Yi Zhang; Cristina Castillejo; joanne chory; Eirini Kaiserli; SD MA
Gibberellins accumulate in the elongating endodermal cells of Arabidopsis root.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(12):4834-9.
2013: Margaret T Butko; Claire Delahunty; Ford Ebner; Beth Friedman; Jeffrey N Savas; John R Yates; Roger Y Tsien
In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):E726-35.
2013: Elamprakash N Savariar; Paul Steinbach; Roger Y Tsien; Lesley G Ellies; Csilla N Felsen; Tao Jiang; Nadia Nashi; Quyen T Nguyen
Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides.
Cancer research 2013;73(2):855-64.
2013: Michael Whitney; Stephen R Adams; Jessica L Crisp; Beth Friedman; Heather L Glasgow; Roy Lefkowitz; Rachel A Levin; Nadia Nashi; Quyen T Nguyen; Elamprakash N Savariar; Paul Steinbach; Roger Y Tsien
Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation.
Angewandte Chemie (International ed. in English) 2013;52(1):325-30.
2013: Ryan K Orosco; Roger Y Tsien; Quyen T Nguyen
Fluorescence imaging in surgery.
IEEE reviews in biomedical engineering 2013;6():178-87.
2012: Margaret T Butko; Mark H Ellisman; Yang Geng; Noo Li Jeon; Hyung Joon Kim; Mason R Mackey; Xiaokun Shu; Roger Y Tsien; Jin Yang; Michael Z Lin
Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy.
Nature neuroscience 2012;15(12):1742-51.
2012: Horng D Ou; Colin J Powers; Xiaokun Shu; Conrado Soria; Roger Y Tsien; Katie Y Blain; Senyon Choe; Thomas J Deerinck; Mark H Ellisman; James A J Fitzpatrick; Witek Kwiatkowski; Hannah S Land; Jeff A Long; Andrew P May; Andrew Noske; Clodagh C. O'Shea
A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors.
Cell 2012;151(2):304-19.
2012: Amy J Lam; Michelle A Baird; Paula J Cranfill; Michael W Davidson; Yiyang Gong; Jesse D Marshall; Michael R McKeown; Mark J Schnitzer; François St-Pierre; Roger Y Tsien; Jörg Wiedenmann; Michael Z Lin
Improving FRET dynamic range with bright green and red fluorescent proteins.
Nature methods 2012;9(10):1005-12.
2012: Emilia S Olson; Roger Y Tsien; Sotirios Tsimikas; Michael A Whitney; Todd A Aguilera; Fred M Baik; Stephen M Baird; Jessica L Crisp; Beth Friedman; Tao Jiang; Quyen T Nguyen
In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity.
Integrative biology : quantitative biosciences from nano to macro 2012;4(6):595-605.
2012: Bo Chen; Qun Cheng; Beth Friedman; I-Farn Lei; Emilia S Olson; Benedict Pereira; Roger Y Tsien; Michael A Whitney; Jessica A Van Winkle; Lifu Zhao; Patrick D Lyden
Thrombin activity associated with neuronal damage during acute focal ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(22):7622-31.
2012: Yingchuan B Qi; Xiaokun Shu; Roger Y Tsien; Emma J Garren; Yishi Jin
Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7499-504.
2012: Evan W Miller; Paul A Steinbach; E Paxon Frady; William B Kristan; John Y Lin; Roger Y Tsien
Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(6):2114-9.
2011: Xiaokun Shu; Varda Lev-Ram; Thomas J Deerinck; Yingchuan Qi; Ericka B Ramko; Michael W Davidson; Yishi Jin; Mark H Ellisman; Roger Y Tsien
A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms.
PLoS biology 2011;9(4):e1001041.
2011: Amy P Wu; Michael A Whitney; Jessica L Crisp; Beth Friedman; Roger Y Tsien; Quyen T Nguyen
Improved facial nerve identification with novel fluorescently labeled probe.
The Laryngoscope 2011;121(4):805-10.
2011: M Whitney; Jessica L Crisp; Linda T Nguyen; Beth Friedman; Larry A Gross; Paul Steinbach; Roger Y Tsien; Quyen T Nguyen
Fluorescent peptides highlight peripheral nerves during surgery in mice.
Nature biotechnology 2011;29(4):352-6.
2011: Haiyan Li; Leslie C Osborne; C Kevin Park; Nathan C Shaner; Roger Y Tsien; Yuriy L Dobryy; Sarah M Foss; Samuel Andrew Hires; Susan M Voglmaier
Concurrent imaging of synaptic vesicle recycling and calcium dynamics.
Frontiers in molecular neuroscience 2011;4():34.
2011: X Shu; Varda Lev-Ram; E S Olson; T A Aguilera; T Jiang; M Whitney; J L Crisp; Paul A Steinbach; Thomas J Deerinck; M H Ellisman; Lesley G Ellies; Q T Nguyen; Roger Y Tsien
Spiers Memorial Lecture. Breeding and building molecular spies.
Faraday discussions 2011;149():9; discussion 63-77.
2010: Richard Ting; Todd A Aguilera; Jessica L Crisp; David J Hall; William C Eckelman; David R Vera; Roger Y Tsien
Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes.
Bioconjugate chemistry 2010;21(10):1811-9.
2010: Antonella De Jaco; Michael Z Lin; Noga Dubi; Davide Comoletti; Meghan T Miller; Shelley Camp; Mark Ellisman; Margaret T Butko; Roger Y Tsien; Palmer Taylor
Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family.
The Journal of biological chemistry 2010;285(37):28674-82.
2010: Carsten Hoffmann; Guido Gaietta; Alexander Zürn; Stephen R Adams; Sonia Terrillon; Mark H Ellisman; Roger Y Tsien; Martin J Lohse
Fluorescent labeling of tetracysteine-tagged proteins in intact cells.
Nature protocols 2010;5(10):1666-77.
2010: Mike Whitney; Jessica L Crisp; Emilia S Olson; Todd A Aguilera; Larry A Gross; Lesley G Ellies; Roger Y Tsien
Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides.
The Journal of biological chemistry 2010;285(29):22532-41.
2010: Mingxing Ouyang; He Huang; Nathan C Shaner; Albert G Remacle; Sergey A Shiryaev; Alex Y Strongin; Roger Y Tsien; Yingxiao Wang
Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.
Cancer research 2010;70(6):2204-12.
2010: Quyen T Nguyen; Emilia S Olson; Todd A Aguilera; Tao Jiang; Miriam Scadeng; Lesley G Ellies; Roger Y Tsien
Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4317-22.
2010: Emilia S Olson; Tao Jiang; Todd A Aguilera; Quyen T Nguyen; Lesley G Ellies; Miriam Scadeng; Roger Y Tsien
Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4311-6.
2010: Roger Y Tsien
Nobel lecture: constructing and exploiting the fluorescent protein paintbox.
Integrative biology : quantitative biosciences from nano to macro 2010;2(2-3):77-93.
2010: Michael Z Lin; Roger Y Tsien
TimeSTAMP tagging of newly synthesized proteins.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2010;Chapter 26():Unit 26.5.
2010: Roger Y Tsien
The 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemistry 2008.
Journal of visualized experiments : JoVE 2010;(35):.
2009: Graham T Dempsey; Mark Bates; Walter E Kowtoniuk; David R. Liu; Roger Y Tsien; Xiaowei Zhuang
Photoswitching mechanism of cyanine dyes.
Journal of the American Chemical Society 2009;131(51):18192-3.
2009: Michael Z Lin; Michael R McKeown; Ho-Leung Ng; Todd A Aguilera; Nathan C Shaner; Robert E Campbell; Stephen R Adams; Larry A Gross; Wendy Ma; Tom Alber; Roger Y Tsien
Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals.
Chemistry & biology 2009;16(11):1169-79.
2009: Roger Y Tsien
Indicators based on fluorescence resonance energy transfer (FRET).
Cold Spring Harbor protocols 2009;2009(7):pdb.top57.
2009: Emilia S Olson; Todd A Aguilera; Tao Jiang; Lesley G Ellies; Quyen T Nguyen; Edmund H Wong; Larry A Gross; Roger Y Tsien
In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer.
Integrative biology : quantitative biosciences from nano to macro 2009;1(5-6):382-93.
2009: Todd A Aguilera; Emilia S Olson; Margaret M Timmers; Tao Jiang; Roger Y Tsien
Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides.
Integrative biology : quantitative biosciences from nano to macro 2009;1(5-6):371-81.
2009: Xiaokun Shu; Antoine Royant; Michael Z Lin; Todd A Aguilera; Varda Lev-Ram; Paul A Steinbach; Roger Y Tsien
Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome.
Science (New York, N.Y.) 2009;324(5928):804-7.
2009: Fatemeh Madani; Jesper Lind; Peter Damberg; Stephen R Adams; Roger Y Tsien; Astrid O Gräslund
Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy.
Journal of the American Chemical Society 2009;131(13):4613-5.
2009: John Y Lin; Michael Z Lin; Paul Steinbach; Roger Y Tsien
Characterization of engineered channelrhodopsin variants with improved properties and kinetics.
Biophysical journal 2009;96(5):1803-14.
2009: Roger Y Tsien
Constructing and exploiting the fluorescent protein paintbox (Nobel Lecture).
Angewandte Chemie (International ed. in English) 2009;48(31):5612-26.
2008: Damian J Wallace; Stephan Meyer zum Alten Borgloh; Simone Astori; Ying Yang; Melanie Bausen; Sebastian Kügler; Amy E Palmer; Roger Y Tsien; Rolf Sprengel; Jason N D Kerr; Winfried Denk; Mazahir T Hasan
Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor.
Nature methods 2008;5(9):797-804.
2008: Michael Z Lin; Jeffrey S Glenn; Roger Y Tsien
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7744-9.
2008: Nathan C Shaner; Michael Z Lin; Michael R McKeown; Paul A Steinbach; Kristin L Hazelwood; Michael W Davidson; Roger Y Tsien
Improving the photostability of bright monomeric orange and red fluorescent proteins.
Nature methods 2008;5(6):545-51.
2008: Samuel Andrew Hires; Yongling Zhu; Roger Y Tsien
Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4411-6.
2008: Stephen R Adams; Roger Y Tsien
Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins.
Nature protocols 2008;3(9):1527-34.
2007: Roger Y Tsien
Roger Tsien: bringing color to cell biology. A passion for chemistry, color, and conversations with cells is what drives Roger Tsien. Interview by Ruth Williams.
The Journal of cell biology 2007;179(1):6-8.
2007: Brent R Martin; Thomas J Deerinck; Mark H Ellisman; Susan S Taylor; Roger Y Tsien
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.
Chemistry & biology 2007;14(9):1031-42.
2007: Oded Tour; Stephen R Adams; Rex A Kerr; Rene M Meijer; Terrence J Sejnowski; Richard W Tsien; Roger Y Tsien
Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator.
Nature chemical biology 2007;3(7):423-31.
2007: Hui-wang Ai; Nathan C Shaner; Zihao Cheng; Roger Y Tsien; Robert E Campbell
Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins.
Biochemistry 2007;46(20):5904-10.
2007: Pritha Ray; Roger Y Tsien; Sanjiv S Gambhir
Construction and validation of improved triple fusion reporter gene vectors for molecular imaging of living subjects.
Cancer research 2007;67(7):3085-93.
2007: Christina T Hauser; Roger Y Tsien
A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3693-7.
2007: Maya T Kunkel; Alex Toker; Roger Y Tsien; Alexandra C Newton
Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter.
The Journal of biological chemistry 2007;282(9):6733-42.
2006: Timothy A Dunn; Chih-Tien Wang; Michael A Colicos; Manuela Zaccolo; Lisa M DiPilato; Jin Zhang; Roger Y Tsien; Marla B Feller
Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(49):12807-15.
2006: Roger Y Tsien
Breeding and building molecules to spy on cells and tumors.
The Keio journal of medicine 2006;55(4):127-40.
2006: Guido Gaietta; Ben N G Giepmans; Thomas J Deerinck; W Bryan Smith; Lucy Ngan; Juan Llopis; Stephen R Adams; Roger Y Tsien; Mark H Ellisman
Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17777-82.
2006: Jeffrey J Saucerman; Jin Zhang; Jody C Martin; Lili X Peng; Antine Elaine Stenbit; Roger Y Tsien; Andrew D McCulloch
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(34):12923-8.
2006: Xiaokun Shu; Nathan C Shaner; Corinne A Yarbrough; Roger Y Tsien; S James Remington
Novel chromophores and buried charges control color in mFruits.
Biochemistry 2006;45(32):9639-47.
2006: Amy E Palmer; Marta Giacomello; Tanja Kortemme; S Andrew Hires; Varda Lev-Ram; David Baker; Roger Y Tsien
Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs.
Chemistry & biology 2006;13(5):521-30.
2006: Jeremy R Babendure; Jennie L Babendure; Jian-Hua Ding; Roger Y Tsien
Control of mammalian translation by mRNA structure near caps.
RNA (New York, N.Y.) 2006;12(5):851-61.
2006: Ben N G Giepmans; Stephen R Adams; Mark H Ellisman; Roger Y Tsien
The fluorescent toolbox for assessing protein location and function.
Science (New York, N.Y.) 2006;312(5771):217-24.
2006: Mingxuan Sun; Judy L Oakes; Shobana K Ananthanarayanan; Katherine H Hawley; Roger Y Tsien; Stephen R Adams; Christopher M Yengo
Dynamics of the upper 50-kDa domain of myosin V examined with fluorescence resonance energy transfer.
The Journal of biological chemistry 2006;281(9):5711-7.
2006: Lei Wang; Roger Y Tsien
Evolving proteins in mammalian cells using somatic hypermutation.
Nature protocols 2006;1(3):1346-50.
2006: Amy E Palmer; Roger Y Tsien
Measuring calcium signaling using genetically targetable fluorescent indicators.
Nature protocols 2006;1(3):1057-65.
2006: David Zacharias; Roger Y Tsien
Molecular biology and mutation of green fluorescent protein.
Methods of biochemical analysis 2006;47():83-120.
2005: Nathan C Shaner; Paul A Steinbach; Roger Y Tsien
A guide to choosing fluorescent proteins.
Nature methods 2005;2(12):905-9.
2005: Brent R Martin; Ben N G Giepmans; Stephen R Adams; Roger Y Tsien
Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity.
Nature biotechnology 2005;23(10):1308-14.
2005: Jin Zhang; Christopher J Hupfeld; Susan S Taylor; Jerrold M Olefsky; Roger Y Tsien
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes.
Nature 2005;437(7058):569-73.
2005: Joshua C Goldstein; Cristina Muñoz-Pinedo; Jean-Ehrland Ricci; S R Adams; A Kelekar; Martin Schuler; Roger Y Tsien; Douglas R Green
Cytochrome c is released in a single step during apoptosis.
Cell death and differentiation 2005;12(5):453-62.
2005: Yingxiao Wang; Elliot L Botvinick; Yihua Zhao; Michael W Berns; Shunichi Usami; Roger Y Tsien; Shu Chien
Visualizing the mechanical activation of Src.
Nature 2005;434(7036):1040-5.
2005: Carsten Hoffmann; Guido Gaietta; Moritz Bünemann; Stephen R Adams; Silke Oberdorff-Maass; Björn Behr; Jean-Pierre Vilardaga; Roger Y Tsien; Mark H Ellisman; Martin J Lohse
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells.
Nature methods 2005;2(3):171-6.
2005: Maya T Kunkel; QIANG NI; Roger Y Tsien; Jin Zhang; Alexandra C Newton
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.
The Journal of biological chemistry 2005;280(7):5581-7.
2005: Roger Y Tsien
Building and breeding molecules to spy on cells and tumors.
FEBS letters 2005;579(4):927-32.
2004: Tao Jiang; Emilia S Olson; Quyen T Nguyen; Melinda Roy; Patricia Jennings; Roger Y Tsien
Tumor imaging by means of proteolytic activation of cell-penetrating peptides.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17867-72.
2004: Amy E Palmer; Can Jin; John C Reed; Roger Y Tsien
Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17404-9.
2004: Nathan C Shaner; Robert E Campbell; Paul A Steinbach; Ben N G Giepmans; Amy E Palmer; Roger Y Tsien
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein.
Nature biotechnology 2004;22(12):1567-72.
2004: Lei Wang; W Coyt Jackson; Paul A Steinbach; Roger Y Tsien
Evolution of new nonantibody proteins via iterative somatic hypermutation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16745-9.
2004: Han-Jung Chae; Hyung-Ryong Kim; Chunyan Xu; Beatrice Bailly-Maitre; Maryla Krajewska; Stan Krajewski; Steven Banares; Janice Cui; Murat Digicaylioglu; Ning Ke; Shinichi Kitada; Edward Monosov; Michael Thomas; Christina L Kress; Jeremy R Babendure; Roger Y Tsien; Stuart A Lipton; John C Reed
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.
Molecular cell 2004;15(3):355-66.
2004: Toshiaki Furuta; Hiroko Takeuchi; Masahiro Isozaki; Yasuhiro Takahashi; Makoto Kanehara; Masazumi Sugimoto; Takayoshi Watanabe; Kousei Noguchi; Timothy M Dore; Takashi Kurahashi; Michiko Iwamura; Roger Y Tsien
Bhc-cNMPs as either water-soluble or membrane-permeant photoreleasable cyclic nucleotides for both one- and two-photon excitation.
Chembiochem : a European journal of chemical biology 2004;5(8):1119-28.
2004: Mazahir T Hasan; Rainer W Friedrich; Thomas Euler; Matthew Larkum; Günter Giese; Matthias Both; Jens Duebel; Jack Waters; Hermann Bujard; Oliver Griesbeck; Roger Y Tsien; Takeharu Nagai; Atsushi Miyawaki; Winfried Denk
Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control.
PLoS biology 2004;2(6):e163.
2004: Colette T Dooley; Timothy M Dore; George T Hanson; W Coyt Jackson; S James Remington; Roger Y Tsien
Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators.
The Journal of biological chemistry 2004;279(21):22284-93.
2004: George T Hanson; Robert Aggeler; Devin Oglesbee; Mark Cannon; Roderick A Capaldi; Roger Y Tsien; S James Remington
Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators.
The Journal of biological chemistry 2004;279(13):13044-53.
2004: William Ju; Wade Morishita; Jennifer Tsui; Guido Gaietta; Thomas J Deerinck; Stephen R Adams; Craig C Garner; Roger Y Tsien; Mark H Ellisman; Robert C Malenka
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors.
Nature neuroscience 2004;7(3):244-53.
2004: Pritha Ray; Abhijit De; Jung-Jun Min; Roger Y Tsien; Sanjiv S Gambhir
Imaging tri-fusion multimodality reporter gene expression in living subjects.
Cancer research 2004;64(4):1323-30.
2003: Varda Lev-Ram; Samar B Mehta; David Kleinfeld; Roger Y Tsien
Reversing cerebellar long-term depression.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15989-93.
2003: Sumitaka Hasegawa; W Coyt Jackson; Roger Y Tsien; Jianghong Rao
Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14892-6.
2003: Jeremy R Babendure; Stephen R Adams; Roger Y Tsien
Aptamers switch on fluorescence of triphenylmethane dyes.
Journal of the American Chemical Society 2003;125(48):14716-7.
2003: Oded Tour; Rene M Meijer; David Zacharias; Stephen R Adams; Roger Y Tsien
Genetically targeted chromophore-assisted light inactivation.
Nature biotechnology 2003;21(12):1505-8.
2003: Wenzhong Gao; Bengang Xing; Roger Y Tsien; Jianghong Rao
Novel fluorogenic substrates for imaging beta-lactamase gene expression.
Journal of the American Chemical Society 2003;125(37):11146-7.
2003: Roger Y Tsien
Imagining imaging's future.
Nature reviews. Molecular cell biology 2003;Suppl():SS16-21.
2003: Philbert S Tsai; Beth Friedman; Agustin I Ifarraguerri; Beverly D Thompson; Varda Lev-Ram; Chris B Schaffer; Qing Xiong; Roger Y Tsien; Jeff A Squier; David Kleinfeld
All-optical histology using ultrashort laser pulses.
Neuron 2003;39(1):27-41.
2003: Gina E Sosinsky; Guido Gaietta; Galen M Hand; Thomas J Deerinck; Areum Han; Mason Mackey; Stephen R Adams; James C Bouwer; Roger Y Tsien; Mark H Ellisman
Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics.
Cell communication & adhesion 2003;10(4-6):181-6.
2003: Jonathan D Violin; Jin Zhang; Roger Y Tsien; Alexandra C Newton
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C.
The Journal of cell biology 2003;161(5):899-909.
2003: Roger Y Tsien
Breeding molecules to spy on cells.
Harvey lectures 2003;99():77-93.
2003: Dinghui Yu; Geoffrey S Baird; Roger Y Tsien; Ronald L Davis
Detection of calcium transients in Drosophila mushroom body neurons with camgaroo reporters.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(1):64-72.
2002: Alfred G Gilman; Melvin I Simon; Henry R Bourne; Bruce A Harris; Rochelle Long; Elliott M Ross; James T Stull; Ronald Taussig; Henry R Bourne; Adam P Arkin; Melanie H Cobb; Jason G Cyster; Peter N Devreotes; James E Ferrell; David A Fruman; Michael Gold; Arthur Weiss; James T Stull; Michael J Berridge; Lewis C Cantley; William A Catterall; Shaun R Coughlin; Eric N Olson; Temple F Smith; Joan S Brugge; David Botstein; Jack E Dixon; Tony Hunter; Robert J Lefkowitz; Anthony J Pawson; Paul W Sternberg; Harold Varmus; Shankar Subramaniam; Robert S Sinkovits; Joshua Li; Dennis Mock; Yuhong Ning; Brian Saunders; Paul C Sternweis; Donald Hilgemann; Richard Scheuermann; Dianne DeCamp; Robert Hsueh; Keng-Mean Lin; Yan Ni; William Seaman; Paul C Simpson; Timothy D O'Connell; Tamara Roach; Melvin I Simon; Sangdun Choi; Pamela Eversole-Cire; Iain Fraser; Marc C Mumby; Yingming Zhao; Deirdre Brekken; Hongjun Shu; Tobias Meyer; Grischa Chandy; Won Do Heo; Jen Liou; Nancy O'Rourke; Mary Verghese; Susanne M Mumby; Heping Han; H Alex Brown; Jeffrey S Forrester; Pavlina Ivanova; Stephen B Milne; Patrick J Casey; T Kendall Harden; Adam P Arkin; John Doyle; Martha Gray; Tobias Meyer; Stephen Michnick; Martin A Schmidt; Mehmet Toner; Roger Y Tsien; Madhusudan Natarajan; Rama Ranganathan; Gilberto R Sambrano
Overview of the Alliance for Cellular Signaling.
Nature 2002;420(6916):703-6.
2002: Jin Zhang; Robert E Campbell; Alice Y Ting; Roger Y Tsien
Creating new fluorescent probes for cell biology.
Nature reviews. Molecular cell biology 2002;3(12):906-18.
2002: Robert E Campbell; Oded Tour; Amy E Palmer; Paul A Steinbach; Geoffrey S Baird; David Zacharias; Roger Y Tsien
A monomeric red fluorescent protein.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):7877-82.
2002: Varda Lev-Ram; Scott T Wong; Daniel R Storm; Roger Y Tsien
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8389-93.
2002: Stephen R Adams; Robert E Campbell; Larry A Gross; Brent R Martin; Grant K Walkup; Yong Yao; Juan Llopis; Roger Y Tsien
New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications.
Journal of the American Chemical Society 2002;124(21):6063-76.
2002: David Zacharias; Jonathan D Violin; Alexandra C Newton; Roger Y Tsien
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells.
Science (New York, N.Y.) 2002;296(5569):913-6.
2002: Guido Gaietta; Thomas J Deerinck; Stephen R Adams; James C Bouwer; Oded Tour; Dale W Laird; Gina E Sosinsky; Roger Y Tsien; Mark H Ellisman
Multicolor and electron microscopic imaging of connexin trafficking.
Science (New York, N.Y.) 2002;296(5567):503-7.
2001: A Y Ting; K H Kain; Richard L Klemke; Roger Y Tsien
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15003-8.
2001: Jin Zhang; Y Ma; Susan S Taylor; Roger Y Tsien
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14997-5002.
2001: MM Wu; Michael Grabe; S Adams; Roger Y Tsien; Hsiao-Ping H Moore; Terry E Machen
Mechanisms of pH regulation in the regulated secretory pathway.
The Journal of biological chemistry 2001;276(35):33027-35.
2001: Shawn C Burdette; G K Walkup; Bernhard Spingler; Roger Y Tsien; Stephen J Lippard
Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution.
Journal of the American Chemical Society 2001;123(32):7831-41.
2001: Oliver Griesbeck; Geoffrey S Baird; Robert E Campbell; David Zacharias; Roger Y Tsien
Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications.
The Journal of biological chemistry 2001;276(31):29188-94.
2001: Francis Ka-Ming Chan; Richard Siegel; David Zacharias; R Swofford; K L Holmes; Roger Y Tsien; Michael J Lenardo
Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein.
Cytometry 2001;44(4):361-8.
2001: Hideki Ando; Toshiaki Furuta; Roger Y Tsien; Hitoshi Okamoto
Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos.
Nature genetics 2001;28(4):317-25.
2001: Akira Honda; S R Adams; Carolyn L Sawyer; Varda Lev-Ram; Roger Y Tsien; Wolfgang R Dostmann
Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2437-42.
2000: pankaj kapahi; T Takahashi; Gioacchino Natoli; S R Adams; Yi Chen; Roger Y Tsien; Michael Karin
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase.
The Journal of biological chemistry 2000;275(46):36062-6.
2000: Ahmed Heikal; Samuel T Hess; G S Baird; Roger Y Tsien; Watt W Webb
Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine).
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11996-2001.
2000: L A Gross; Geoffrey S Baird; R C Hoffman; Kim K Baldridge; Roger Y Tsien
The structure of the chromophore within DsRed, a red fluorescent protein from coral.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11990-5.
2000: Geoffrey S Baird; David Zacharias; Roger Y Tsien
Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11984-9.
2000: Gethyn J Allen; Sarah P Chu; Karin Schumacher; C T Shimazaki; Dionne Vafeados; Andrea Kemper; S D Hawke; Gary Tallman; Roger Y Tsien; Jeffrey F Harper; joanne chory; Julian I Schroeder
Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant.
Science (New York, N.Y.) 2000;289(5488):2338-42.
2000: Richard Siegel; J K Frederiksen; David Zacharias; Francis Ka-Ming Chan; M Johnson; D Lynch; Roger Y Tsien; Michael J Lenardo
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.
Science (New York, N.Y.) 2000;288(5475):2354-7.
2000: Richard Siegel; Francis Ka-Ming Chan; David Zacharias; R Swofford; K L Holmes; Roger Y Tsien; Michael J Lenardo
Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein.
Science's STKE : signal transduction knowledge environment 2000;2000(38):pl1.
2000: Rex Kerr; Varda Lev-Ram; G Baird; P Vincent; Roger Y Tsien; William R Schafer
Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans.
Neuron 2000;26(3):583-94.
2000: S Matsuyama; J Llopis; Quinn Deveraux; Roger Y Tsien; John C Reed
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis.
Nature cell biology 2000;2(6):318-25.
2000: David Zacharias; Geoffrey S Baird; Roger Y Tsien
Recent advances in technology for measuring and manipulating cell signals.
Current opinion in neurobiology 2000;10(3):416-21.
2000: Juan Llopis; S Westin; Mercedes Ricote; Zuncai Wang; C Y Cho; R Kurokawa; TM Mullen; David W Rose; Michael G Rosenfeld; Roger Y Tsien; Christopher K Glass; J Wang
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4363-8.
2000: MM Wu; Juan Llopis; S Adams; J M McCaffery; Markku Kulomaa; Terry E Machen; Hsiao-Ping H Moore; Roger Y Tsien
Organelle pH studies using targeted avidin and fluorescein-biotin.
Chemistry & biology 2000;7(3):197-209.
2000: D Thomas; Peter Lipp; SC Tovey; Michael J Berridge; W Li; Roger Y Tsien; Martin D Bootman
Microscopic properties of elementary Ca2+ release sites in non-excitable cells.
Current biology : CB 2000;10(1):8-15.
2000: B A Griffin; S R Adams; J Jones; Roger Y Tsien
Fluorescent labeling of recombinant proteins in living cells with FlAsH.
Methods in enzymology 2000;327():565-78.
2000: MM Wu; Juan Llopis; Stephen R Adams; J M McCaffery; K Teter; Markku Kulomaa; Terry E Machen; Hsiao-Ping H Moore; Roger Y Tsien
Studying organelle physiology with fusion protein-targeted avidin and fluorescent biotin conjugates.
Methods in enzymology 2000;327():546-64.
2000: A Miyawaki; Roger Y Tsien
Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein.
Methods in enzymology 2000;327():472-500.
2000: Manuela Zaccolo; F De Giorgi; C Y Cho; L Feng; Tom Knapp; Paul Negulescu; S S Taylor; Roger Y Tsien; Tullio Pozzan
A genetically encoded, fluorescent indicator for cyclic AMP in living cells.
Nature cell biology 2000;2(1):25-9.
1999: Roger Y Tsien
Rosy dawn for fluorescent proteins.
Nature biotechnology 1999;17(10):956-7.
1999: Geoffrey S Baird; David Zacharias; Roger Y Tsien
Circular permutation and receptor insertion within green fluorescent proteins.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11241-6.
1999: Gethyn J Allen; June M Kwak; Sarah P Chu; Juan Llopis; Roger Y Tsien; Jeffrey F Harper; Julian I Schroeder
Cameleon calcium indicator reports cytoplasmic calcium dynamics in Arabidopsis guard cells.
The Plant journal : for cell and molecular biology 1999;19(6):735-47.
1999: Y Yao; Antonio Ferrer-Montiel; Mauricio Montal; Roger Y Tsien
Activation of store-operated Ca2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger.
Cell 1999;98(4):475-85.
1999: TW Cacciatore; P D Brodfuehrer; J E Gonzalez; T Jiang; Stephen R Adams; Roger Y Tsien; William B Kristan; David Kleinfeld
Identification of neural circuits by imaging coherent electrical activity with FRET-based dyes.
Neuron 1999;23(3):449-59.
1999: GY Fan; H Fujisaki; A Miyawaki; R K Tsay; Roger Y Tsien; Mark H Ellisman
Video-rate scanning two-photon excitation fluorescence microscopy and ratio imaging with cameleons.
Biophysical journal 1999;76(5):2412-20.
1999: C J Li; R Heim; P Lu; Y Pu; Roger Y Tsien; Donald C Chang
Dynamic redistribution of calmodulin in HeLa cells during cell division as revealed by a GFP-calmodulin fusion protein technique.
Journal of cell science 1999;112 ( Pt 10)():1567-77.
1999: P Lin; Y Yao; R Hofmeister; Roger Y Tsien; Marilyn G Farquhar
Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi.
The Journal of cell biology 1999;145(2):279-89.
1999: A Miyawaki; Oliver Griesbeck; R Heim; Roger Y Tsien
Dynamic and quantitative Ca2+ measurements using improved cameleons.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2135-40.
1999: Toshiaki Furuta; S S Wang; Jami L M Dantzker; Timothy M Dore; W J Bybee; Edward M Callaway; W Denk; Roger Y Tsien
Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1193-200.
1999: E B Brown; JB Shear; S R Adams; Roger Y Tsien; Watt W Webb
Photolysis of caged calcium in femtoliter volumes using two-photon excitation.
Biophysical journal 1999;76(1 Pt 1):489-99.
1998: erez raz; Gregor Zlokarnik; Roger Y Tsien; Wolfgang Driever
beta-lactamase as a marker for gene expression in live zebrafish embryos.
Developmental biology 1998;203(2):290-4.
1998: B A Griffin; S R Adams; Roger Y Tsien
Specific covalent labeling of recombinant protein molecules inside live cells.
Science (New York, N.Y.) 1998;281(5374):269-72.
1998: Roger Y Tsien; A Miyawaki
Seeing the machinery of live cells.
Science (New York, N.Y.) 1998;280(5371):1954-5.
1998: Juan Llopis; JM McCaffery; A Miyawaki; Marilyn G Farquhar; Roger Y Tsien
Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6803-8.
1998: T Jiang; G Sweeney; M T Rudolf; A Klip; Alexis E Traynor-Kaplan; Roger Y Tsien
Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate.
The Journal of biological chemistry 1998;273(18):11017-24.
1998: W Li; Juan Llopis; M Whitney; Gregor Zlokarnik; Roger Y Tsien
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression.
Nature 1998;392(6679):936-41.
1998: Gregor Zlokarnik; Paul Negulescu; Tom Knapp; L Mere; N Burres; L Feng; M Whitney; K Roemer; Roger Y Tsien
Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter.
Science (New York, N.Y.) 1998;279(5347):84-8.
1998: Roger Y Tsien
The green fluorescent protein.
Annual review of biochemistry 1998;67():509-44.
1997: Lars Eckmann; Marco T Rudolf; A Ptasznik; Carsten Schultz; T Jiang; N Wolfson; Roger Y Tsien; Joshua Fierer; S B Shears; Martin F Kagnoff; Alexis E Traynor-Kaplan
D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14456-60.
1997: S R Adams; Varda Lev-Ram; Roger Y Tsien
A new caged Ca2+, azid-1, is far more photosensitive than nitrobenzyl-based chelators.
Chemistry & biology 1997;4(11):867-78.
1997: A Miyawaki; Juan Llopis; R Heim; JM McCaffery; J A Adams; M Ikura; Roger Y Tsien
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin.
Nature 1997;388(6645):882-7.
1997: Rebekka M Wachter; Brett A King; R Heim; Karen Kallio; Roger Y Tsien; Steven G Boxer; S James Remington
Crystal structure and photodynamic behavior of the blue emission variant Y66H/Y145F of green fluorescent protein.
Biochemistry 1997;36(32):9759-65.
1997: Robert M Dickson; A B Cubitt; Roger Y Tsien; WE Moerner
On/off blinking and switching behaviour of single molecules of green fluorescent protein.
Nature 1997;388(6640):355-8.
1997: Y Yao; Roger Y Tsien
Calcium current activated by depletion of calcium stores in Xenopus oocytes.
The Journal of general physiology 1997;109(6):703-15.
1997: Varda Lev-Ram; T Jiang; J Wood; David S Lawrence; Roger Y Tsien
Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellar long-term depression.
Neuron 1997;18(6):1025-38.
1997: Varda Lev-Ram; Z Nebyelul; Mark H Ellisman; P L Huang; Roger Y Tsien
Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase.
Learning & memory (Cold Spring Harbor, N.Y.) 1997;4(1):169-77.
1997: J E González; Roger Y Tsien
Improved indicators of cell membrane potential that use fluorescence resonance energy transfer.
Chemistry & biology 1997;4(4):269-77.
1997: Katjusa Brejc; Titia K Sixma; PA Kitts; SR Kain; Roger Y Tsien; M Ormö; S James Remington
Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2306-11.
1996: Ottavio Arancio; M Kiebler; C J Lee; V Lev-Ram; Roger Y Tsien; Eric R Kandel; Robert D Hawkins
Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons.
Cell 1996;87(6):1025-35.
1996: C M Hempel; P Vincent; S R Adams; Roger Y Tsien; Allen I Selverston
Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuitm.
Nature 1996;384(6605):166-9.
1996: M Ormö; A B Cubitt; Karen Kallio; L A Gross; Roger Y Tsien; S James Remington
Crystal structure of the Aequorea victoria green fluorescent protein.
Science (New York, N.Y.) 1996;273(5280):1392-5.
1996: W J Scheenen; L R Makings; L R Gross; T Pozzan; Roger Y Tsien
Photodegradation of indo-1 and its effect on apparent Ca2+ concentrations.
Chemistry & biology 1996;3(9):765-74.
1996: Rosario Rizzuto; Marisa Brini; F De Giorgi; R Rossi; R Heim; Roger Y Tsien; Tullio Pozzan
Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo.
Current biology : CB 1996;6(2):183-8.
1996: R Heim; Roger Y Tsien
Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer.
Current biology : CB 1996;6(2):178-82.
1996: Ottavio Arancio; V Lev-Ram; Roger Y Tsien; Eric R Kandel; Robert D Hawkins
Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons.
Journal of physiology, Paris 1996;90(5-6):321-2.
1995: A B Cubitt; R Heim; S R Adams; A E Boyd; L A Gross; Roger Y Tsien
Understanding, improving and using green fluorescent proteins.
Trends in biochemical sciences 1995;20(11):448-55.
1995: J E González; Roger Y Tsien
Voltage sensing by fluorescence resonance energy transfer in single cells.
Biophysical journal 1995;69(4):1272-80.
1995: W Wen; Judy L Meinkoth; Roger Y Tsien; Susan S Taylor
Identification of a signal for rapid export of proteins from the nucleus.
Cell 1995;82(3):463-73.
1995: Varda Lev-Ram; L R Makings; P F Keitz; Joseph Kao; Roger Y Tsien
Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients.
Neuron 1995;15(2):407-15.
1995: M Vajanaphanich; Carsten Schultz; Roger Y Tsien; Alexis E Traynor-Kaplan; Stephen J Pandol; Kim E Barrett
Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells.
The Journal of clinical investigation 1995;96(1):386-93.
1995: R Heim; A B Cubitt; Roger Y Tsien
Improved green fluorescence.
Nature 1995;373(6516):663-4.
1995: C Randriamampita; Roger Y Tsien
Degradation of a calcium influx factor (CIF) can be blocked by phosphatase inhibitors or chelation of Ca2+.
The Journal of biological chemistry 1995;270(1):29-32.
1995: Brian J Bacskai; P Wallén; Varda Lev-Ram; S Grillner; Roger Y Tsien
Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy.
Neuron 1995;14(1):19-28.
1994: W Wen; A T Harootunian; S R Adams; James R Feramisco; Roger Y Tsien; Judy L Meinkoth; Susan S Taylor
Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal.
The Journal of biological chemistry 1994;269(51):32214-20.
1994: R Heim; Douglas Prasher; Roger Y Tsien
Wavelength mutations and posttranslational autoxidation of green fluorescent protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12501-4.
1994: M Vajanaphanich; Carsten Schultz; M T Rudolf; M Wasserman; Enyedi Peter; A Craxton; Stephen B Shears; Roger Y Tsien; Kim E Barrett; Alexis E Traynor-Kaplan
Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4.
Nature 1994;371(6499):711-4.
1994: Carsten Schultz; M Vajanaphanich; Hans-Gottfried Genieser; B Jastorff; Kim E Barrett; Roger Y Tsien
Membrane-permeant derivatives of cyclic AMP optimized for high potency, prolonged activity, or rapid reversibility.
Molecular pharmacology 1994;46(4):702-8.
1994: Rama Ranganathan; Brian J Bacskai; Roger Y Tsien; Charles S Zuker
Cytosolic calcium transients: spatial localization and role in Drosophila photoreceptor cell function.
Neuron 1994;13(4):837-48.
1994: Roberto Civitelli; Brian J Bacskai; M P Mahaut-Smith; S R Adams; Louis V Avioli; Roger Y Tsien
Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(9):1407-17.
1994: Thomas J Deerinck; Maryann E Martone; Varda Lev-Ram; D P Green; Roger Y Tsien; David L Spector; S Huang; Mark H Ellisman
Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy.
The Journal of cell biology 1994;126(4):901-10.
1994: D Gurantz; A T Harootunian; Roger Y Tsien; Vincent E Dionne; J F Margiotta
VIP modulates neuronal nicotinic acetylcholine receptor function by a cyclic AMP-dependent mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(6):3540-7.
1994: Reto Asmis; C Randriamampita; Roger Y Tsien; Edward A Dennis
Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells.
The Biochemical journal 1994;298 Pt 3():543-51.
1994: L R Makings; Roger Y Tsien
Caged nitric oxide. Stable organic molecules from which nitric oxide can be photoreleased.
The Journal of biological chemistry 1994;269(9):6282-5.
1994: D A Fantozzi; A T Harootunian; W Wen; Susan S Taylor; James R Feramisco; Roger Y Tsien; Judy L Meinkoth
Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus.
The Journal of biological chemistry 1994;269(4):2676-86.
1993: A T Harootunian; S R Adams; W Wen; Judy L Meinkoth; Susan S Taylor; Roger Y Tsien
Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion.
Molecular biology of the cell 1993;4(10):993-1002.
1993: C Randriamampita; Roger Y Tsien
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx.
Nature 1993;364(6440):809-14.
1993: M Hagiwara; Paul K Brindle; A Harootunian; R Armstrong; J Rivier; W Vale; Roger Y Tsien; Marc Montminy
Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.
Molecular and cellular biology 1993;13(8):4852-9.
1993: Roger Y Tsien; Brian J Bacskai; S R Adams
FRET for studying intracellular signalling.
Trends in cell biology 1993;3(7):242-5.
1993: Brian J Bacskai; B Hochner; M Mahaut-Smith; S R Adams; B K Kaang; Eric R Kandel; Roger Y Tsien
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.
Science (New York, N.Y.) 1993;260(5105):222-6.
1993: V J LaMorte; A T Harootunian; Allen Spiegel; Roger Y Tsien; James R Feramisco
Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2.
The Journal of cell biology 1993;121(1):91-9.
1993: Carsten Schultz; M Vajanaphanich; A T Harootunian; P J Sammak; Kim E Barrett; Roger Y Tsien
Acetoxymethyl esters of phosphates, enhancement of the permeability and potency of cAMP.
The Journal of biological chemistry 1993;268(9):6316-22.
1993: S R Adams; Roger Y Tsien
Controlling cell chemistry with caged compounds.
Annual review of physiology 1993;55():755-84.
1993: S Adams; Brian J Bacskai; A T Harootunian; M Mahaut-Smith; P J Sammak; Susan S Taylor; Roger Y Tsien
Imaging of cAMP signals and A-kinase translocation in single living cells.
Advances in second messenger and phosphoprotein research 1993;28():167-70.
1993: S R Adams; Brian J Bacskai; B Hochner; B K Kaang; Eric R Kandel; M Mahaut-Smith; Roger Y Tsien
Confocal imaging of cAMP signals in Aplysia neurons.
The Japanese journal of physiology 1993;43 Suppl 1():S91-3.
1992: Roger Y Tsien
Intracellular signal transduction in four dimensions: from molecular design to physiology.
The American journal of physiology 1992;263(4 Pt 1):C723-8.
1992: P J Sammak; S R Adams; A T Harootunian; M Schliwa; Roger Y Tsien
Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging.
The Journal of cell biology 1992;117(1):57-72.
1991: S R Adams; A T Harootunian; Y J Buechler; Susan S Taylor; Roger Y Tsien
Fluorescence ratio imaging of cyclic AMP in single cells.
Nature 1991;349(6311):694-7.
1991: A T Harootunian; Joseph Kao; S Paranjape; S R Adams; B V Potter; Roger Y Tsien
Cytosolic Ca2+ oscillations in REF52 fibroblasts: Ca(2+)-stimulated IP3 production or voltage-dependent Ca2+ channels as key positive feedback elements.
Cell calcium 1991;12(2-3):153-64.
1991: A T Harootunian; Joseph Kao; S Paranjape; Roger Y Tsien
Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3.
Science (New York, N.Y.) 1991;251(4989):75-8.
1990: Joseph Kao; Janet Marilyn Alderton; Roger Y Tsien; Richard A Steinhardt
Active involvement of Ca2+ in mitotic progression of Swiss 3T3 fibroblasts.
The Journal of cell biology 1990;111(1):183-96.
1990: Roger Y Tsien; A T Harootunian
Practical design criteria for a dynamic ratio imaging system.
Cell calcium 1990;11(2-3):93-109.
1990: P A Negulescu; A Harootunian; Roger Y Tsien; Terry E Machen
Fluorescence measurements of cytosolic free Na concentration, influx and efflux in gastric cells.
Cell regulation 1990;1(3):259-68.
1990: Richard W Tsien; Roger Y Tsien
Calcium channels, stores, and oscillations.
Annual review of cell biology 1990;6():715-60.
1990: A T Harootunian; Joseph Kao; S R Adams; Roger Y Tsien
Imaging and manipulation of cytosolic ions and messengers during cell activation.
Journal of cell science. Supplement 1990;13():1-4.
1989: A Minta; Roger Y Tsien
Fluorescent indicators for cytosolic sodium.
The Journal of biological chemistry 1989;264(32):19449-57.
1989: A T Harootunian; Joseph Kao; B K Eckert; Roger Y Tsien
Fluorescence ratio imaging of cytosolic free Na+ in individual fibroblasts and lymphocytes.
The Journal of biological chemistry 1989;264(32):19458-67.
1989: T Kawanishi; L M Blank; A T Harootunian; M T Smith; Roger Y Tsien
Ca2+ oscillations induced by hormonal stimulation of individual fura-2-loaded hepatocytes.
The Journal of biological chemistry 1989;264(22):12859-66.
1989: Joseph Kao; A T Harootunian; Roger Y Tsien
Photochemically generated cytosolic calcium pulses and their detection by fluo-3.
The Journal of biological chemistry 1989;264(14):8179-84.
1989: A Minta; Joseph Kao; Roger Y Tsien
Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores.
The Journal of biological chemistry 1989;264(14):8171-8.
1989: W L Havran; M Poenie; R E Tigelaar; Roger Y Tsien; James P Allison
Phenotypic and functional analysis of gamma delta T cell receptor-positive murine dendritic epidermal clones.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(5):1422-8.
1989: Roger Y Tsien
Fluorescence ratio imaging of dynamic intracellular signals.
Acta physiologica Scandinavica. Supplementum 1989;582():6.
1989: Roger Y Tsien; T Pozzan
Measurement of cytosolic free Ca2+ with quin2.
Methods in enzymology 1989;172():230-62.
1989: Roger Y Tsien
Fluorescent probes of cell signaling.
Annual review of neuroscience 1989;12():227-53.
1989: Roger Y Tsien
Fluorescent indicators of ion concentrations.
Methods in cell biology 1989;30():127-56.
1988: Roger Y Tsien
Fluorescence measurement and photochemical manipulation of cytosolic free calcium.
Trends in neurosciences 1988;11(10):419-24.
1988: G M Ratto; R Payne; William G Owen; Roger Y Tsien
The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(9):3240-6.
1988: D Lipscombe; D V Madison; M Poenie; H Reuter; Richard W Tsien; Roger Y Tsien
Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons.
Neuron 1988;1(5):355-65.
1988: Joseph Kao; Roger Y Tsien
Ca2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements.
Biophysical journal 1988;53(4):635-9.
1988: D Lipscombe; D V Madison; M Poenie; H Reuter; Roger Y Tsien; Richard W Tsien
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2398-402.
1988: S K Ambler; M Poenie; Roger Y Tsien; Palmer Taylor
Agonist-stimulated oscillations and cycling of intracellular free calcium in individual cultured muscle cells.
The Journal of biological chemistry 1988;263(4):1952-9.
1988: A T Harootunian; Joseph Kao; Roger Y Tsien
Agonist-induced calcium oscillations in depolarized fibroblasts and their manipulation by photoreleased Ins(1,4,5)P3, Ca++, and Ca++ buffer.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():935-43.
1988: C Langlet; Annick Guimezanes; P Kaldy; Claude Boyer; Michel Buferne; M Poenie; Roger Y Tsien; O Leo; J Bluestone; Lee Leserman
Role of Ti/CD3, Thy-1, and Ly-6 in cytolytic T-cell activation analyzed with Ti loss variants.
Annals of the New York Academy of Sciences 1988;532():33-43.
1987: W L Havran; M Poenie; J Kimura; Roger Y Tsien; A Weiss; James P Allison
Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes.
Nature 1987;330(6144):170-3.
1987: W S Chen; C S Lazar; M Poenie; Roger Y Tsien; G N Gill; M G Rosenfeld
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor.
Nature 1987;328(6133):820-3.
1987: M Poenie; Roger Y Tsien; A M Schmitt-Verhulst
Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets.
The EMBO journal 1987;6(8):2223-32.
1987: H A Wilson; D Greenblatt; M Poenie; F D Finkelman; Roger Y Tsien
Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium.
The Journal of experimental medicine 1987;166(2):601-6.
1987: T M Chused; H A Wilson; D Greenblatt; Y Ishida; L J Edison; Roger Y Tsien; F D Finkelman
Flow cytometric analysis of murine splenic B lymphocyte cytosolic free calcium response to anti-IgM and anti-IgD.
Cytometry 1987;8(4):396-404.
1987: Anthony M Paradiso; Roger Y Tsien; J R Demarest; Terry E Machen
Na-H and Cl-HCO3 exchange in rabbit oxyntic cells using fluorescence microscopy.
The American journal of physiology 1987;253(1 Pt 1):C30-6.
1987: A M Gurney; Roger Y Tsien; H A Lester
Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(10):3496-500.
1987: H A Wilson; D Greenblatt; C W Taylor; J W Putney; Roger Y Tsien; F D Finkelman; T M Chused
The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fc gamma receptor.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1712-8.
1987: Anne-Marie Schmitt-Verhulst; Annick Guimezanes; Claude Boyer; M Poenie; Roger Y Tsien; Michel Buferne; C Hua; Lee Leserman
Pleiotropic loss of activation pathways in a T-cell receptor alpha-chain deletion variant of a cytolytic T-cell clone.
Nature 1987;325(6105):628-31.
1987: Anthony M Paradiso; Roger Y Tsien; Terry E Machen
Digital image processing of intracellular pH in gastric oxyntic and chief cells.
Nature 1987;325(6103):447-50.
1986: Roger Y Tsien; R S Zucker
Control of cytoplasmic calcium with photolabile tetracarboxylate 2-nitrobenzhydrol chelators.
Biophysical journal 1986;50(5):843-53.
1986: J LaBaer; Roger Y Tsien; K A Fahey; A L DeFranco
Stimulation of the antigen receptor on WEHI-231 B lymphoma cells results in a voltage-independent increase in cytoplasmic calcium.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(6):1836-44.
1986: M Poenie; Janet Marilyn Alderton; Richard A Steinhardt; Roger Y Tsien
Calcium rises abruptly and briefly throughout the cell at the onset of anaphase.
Science (New York, N.Y.) 1986;233(4766):886-9.
1986: I A Drummond; S A McClure; M Poenie; Roger Y Tsien; Richard A Steinhardt
Large changes in intracellular pH and calcium observed during heat shock are not responsible for the induction of heat shock proteins in Drosophila melanogaster.
Molecular and cellular biology 1986;6(5):1767-75.
1986: M Poenie; Roger Y Tsien
Fura-2: a powerful new tool for measuring and imaging [Ca2+]i in single cells.
Progress in clinical and biological research 1986;210():53-6.
1986: Roger Y Tsien
New tetracarboxylate chelators for fluorescence measurement and photochemical manipulation of cytosolic free calcium concentrations.
Society of General Physiologists series 1986;40():327-45.
1985: D A Williams; Kevin E Fogarty; Roger Y Tsien; Fred S Fay
Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2.
Nature 1985;318(6046):558-61.
1985: Julio L Vergara; Roger Y Tsien; M Delay
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(18):6352-6.
1985: M Poenie; Janet Marilyn Alderton; Roger Y Tsien; Richard A Steinhardt
Changes of free calcium levels with stages of the cell division cycle.
Nature 1985;315(6015):147-9.
1985: Roger Y Tsien; T J Rink; M Poenie
Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths.
Cell calcium 1985;6(1-2):145-57.
1985: G Grynkiewicz; M Poenie; Roger Y Tsien
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
The Journal of biological chemistry 1985;260(6):3440-50.
1985: P Arslan; F Di Virgilio; M Beltrame; Roger Y Tsien; T Pozzan
Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+.
The Journal of biological chemistry 1985;260(5):2719-27.
1984: Anthony M Paradiso; Roger Y Tsien; Terry E Machen
Na+-H+ exchange in gastric glands as measured with a cytoplasmic-trapped, fluorescent pH indicator.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7436-40.
1984: Roger Y Tsien
Measuring and manipulating cytosolic Ca2+ with trapped indicators.
Kroc Foundation series 1984;17():147-55.
1984: Roger Y Tsien; T Pozzan; T J Rink
Calcium activities and fluxes inside small intact cells as measured with intracellularly trapped chelators.
Advances in cyclic nucleotide and protein phosphorylation research 1984;17():535-41.
1984: J Meldolesi; W B Huttner; Roger Y Tsien; T Pozzan
Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(2):620-4.
1983: T Pozzan; D P Lew; C B Wollheim; Roger Y Tsien
Is cytosolic ionized calcium regulating neutrophil activation?
Science (New York, N.Y.) 1983;221(4618):1413-5.
1983: W H Moolenaar; Roger Y Tsien; P T van der Saag; S W de Laat
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts.
Nature 1983;304(5927):645-8.
1983: Roger Y Tsien
Intracellular measurements of ion activities.
Annual review of biophysics and bioengineering 1983;12():91-116.
1982: T J Rink; S W Smith; Roger Y Tsien
Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent activation for shape-change and secretion.
FEBS letters 1982;148(1):21-6.
1982: T J Rink; Roger Y Tsien; T Pozzan
Cytoplasmic pH and free Mg2+ in lymphocytes.
The Journal of cell biology 1982;95(1):189-96.
1982: T J Rink; Roger Y Tsien
Cytoplasmic free [Ca2+] in very small intact cells.
Biochemical Society transactions 1982;10(4):209.
1982: Roger Y Tsien; T Pozzan; T J Rink
Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.
The Journal of cell biology 1982;94(2):325-34.
1982: T Pozzan; P Arslan; Roger Y Tsien; T J Rink
Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes.
The Journal of cell biology 1982;94(2):335-40.
1982: Virgilio L Lew; Roger Y Tsien; C Miner; Robert M Bookchin
Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator.
Nature 1982;298(5873):478-81.
1982: Roger Y Tsien; S B Hladky
Ion repulsion within membranes.
Biophysical journal 1982;39(1):49-56.
1982: Roger Y Tsien; T Pozzan; T J Rink
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes.
Nature 1982;295(5844):68-71.
1981: Roger Y Tsien; T J Rink
Ca2+-selective electrodes: a novel PVC-gelled neutral carrier mixture compared with other currently available sensors.
Journal of neuroscience methods 1981;4(1):73-86.
1981: F J Alvarez-Leefmans; T J Rink; Roger Y Tsien
Free calcium ions in neurones of Helix aspersa measured with ion-selective micro-electrodes.
The Journal of physiology 1981;315():531-48.
1981: Roger Y Tsien
A non-disruptive technique for loading calcium buffers and indicators into cells.
Nature 1981;290(5806):527-8.
1980: Eduardo Marban; T J Rink; Richard W Tsien; Roger Y Tsien
Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes.
Nature 1980;286(5776):845-50.
1980: Roger Y Tsien; T J Rink
Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium.
Biochimica et biophysica acta 1980;599(2):623-38.
1980: Roger Y Tsien
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.
Biochemistry 1980;19(11):2396-404.
1980: T J Rink; Roger Y Tsien; A E Warner
Free calcium in Xenopus embryos measured with ion-selective microelectrodes.
Nature 1980;283(5748):658-60.
1980: T J Rink; C Montecucco; T R Hesketh; Roger Y Tsien
Lymphocyte membrane potential assessed with fluorescent probes.
Biochimica et biophysica acta 1980;595(1):15-30.
1978: Roger Y Tsien
A virial expansion for discrete charges buried in a membrane.
Biophysical journal 1978;24(2):561-7.
1978: C C Ashley; T J Rink; Roger Y Tsien
Changes in free Ca during muscle contraction, measured with an intracellular Ca-selective electrode [proceedings].
The Journal of physiology 1978;280():27P.
1978: Roger Y Tsien; S B Hladky
A quantitative resolution of the spectra of a membrane potential indicator, diS-C3-(5), bound to cell components and to red blood cells.
The Journal of membrane biology 1978;38(1-2):73-97.
1975: Roger Y Tsien; D P Green; S R Levinson; Bernardo Rudy; J K Sanders
A pharmacologically active derivative of tetrodotoxin.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1975;191(1105):555-9.