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Roger Tsien

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Anatomy

Procedures

Living Beings

Mice
Rats

Concepts & Ideas

Physiology

Signal Transduction

Genes & Molecular Sequences

Amino Acid Sequence

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Co-Publications
Name
13
Adams, Stephen
13
Lev-Ram, Varda
11
Zacharias, David
10
Kao, Joseph
10
Ellisman, Mark
9
Llopis, Juan
9
Taylor, Susan
7
Zhang, Jin
7
Machen, Terry
6
Deerinck, Thomas
6
Baird, Geoffrey
6
Steinbach, Paul
6
Remington, James
6
Palmer, Amy
5
Gaietta, Guido

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Publications

TOP 3
Shu Xiaokun; Royant Antoine; Lin Michael Z; Aguilera Todd A; Lev-Ram Varda; Steinbach Paul A; Tsien Roger Y
Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome.
Madani Fatemeh; Lind Jesper; Damberg Peter; Adams Stephen R; Tsien Roger Y; Gräslund Astrid O
Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy.
Lin John Y; Lin Michael Z; Steinbach Paul; Tsien Roger Y
Characterization of engineered channelrhodopsin variants with improved properties and kinetics.

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All Publications

2009: Shu Xiaokun; Royant Antoine; Lin Michael Z; Aguilera Todd A; Lev-Ram Varda; Steinbach Paul A; Tsien Roger Y
Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome.
Science (New York, N.Y.) 2009;324(5928):804-7.
2009: Madani Fatemeh; Lind Jesper; Damberg Peter; Adams Stephen R; Tsien Roger Y; Gräslund Astrid O
Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy.
Journal of the American Chemical Society 2009;131(13):4613-5.
2009: Lin John Y; Lin Michael Z; Steinbach Paul; Tsien Roger Y
Characterization of engineered channelrhodopsin variants with improved properties and kinetics.
Biophysical journal 2009;96(5):1803-14.
2009: Tsien Roger Y
Constructing and exploiting the fluorescent protein paintbox (Nobel Lecture).
Angewandte Chemie (International ed. in English) 2009;48(31):5612-26.
2008: Wallace Damian J; Meyer zum Alten Borgloh Stephan; Astori Simone; Yang Ying; Bausen Melanie; Kügler Sebastian; Palmer Amy E; Tsien Roger Y; Sprengel Rolf; Kerr Jason N D; Denk Winfried; Hasan Mazahir T
Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor.
Nature methods 2008;5(9):797-804.
2008: Lin Michael Z; Glenn Jeffrey S; Tsien Roger Y
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7744-9.
2008: Shaner Nathan C; Lin Michael Z; McKeown Michael R; Steinbach Paul A; Hazelwood Kristin L; Davidson Michael W; Tsien Roger Y
Improving the photostability of bright monomeric orange and red fluorescent proteins.
Nature methods 2008;5(6):545-51.
2008: Hires Samuel Andrew; Zhu Yongling; Tsien Roger Y
Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4411-6.
2008: Adams Stephen R; Tsien Roger Y
Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins.
Nature protocols 2008;3(9):1527-34.
2007: Tsien Roger
Roger Tsien: bringing color to cell biology. A passion for chemistry, color, and conversations with cells is what drives Roger Tsien. Interview by Ruth Williams.
The Journal of cell biology 2007;179(1):6-8.
2007: Martin Brent R; Deerinck Thomas J; Ellisman Mark H; Taylor Susan S; Tsien Roger Y
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.
Chemistry & biology 2007;14(9):1031-42.
2007: Tour Oded; Adams Stephen R; Kerr Rex A; Meijer Rene M; Sejnowski Terrence J; Tsien Richard W; Tsien Roger Y
Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator.
Nature chemical biology 2007;3(7):423-31.
2007: Ai Hui-wang; Shaner Nathan C; Cheng Zihao; Tsien Roger Y; Campbell Robert E
Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins.
Biochemistry 2007;46(20):5904-10.
2007: Ray Pritha; Tsien Roger; Gambhir Sanjiv Sam
Construction and validation of improved triple fusion reporter gene vectors for molecular imaging of living subjects.
Cancer research 2007;67(7):3085-93.
2007: Hauser Christina T; Tsien Roger Y
A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3693-7.
2007: Kunkel Maya T; Toker Alex; Tsien Roger Y; Newton Alexandra C
Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter.
The Journal of biological chemistry 2007;282(9):6733-42.
2006: Tsien Roger Y
Breeding and building molecules to spy on cells and tumors.
The Keio journal of medicine 2006;55(4):127-40.
2006: Dunn Timothy A; Wang Chih-Tien; Colicos Michael A; Zaccolo Manuela; DiPilato Lisa M; Zhang Jin; Tsien Roger Y; Feller Marla B
Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(49):12807-15.
2006: Gaietta Guido M; Giepmans Ben N G; Deerinck Thomas J; Smith W Bryan; Ngan Lucy; Llopis Juan; Adams Stephen R; Tsien Roger Y; Ellisman Mark H
Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17777-82.
2006: Saucerman Jeffrey J; Zhang Jin; Martin Jody C; Peng Lili X; Stenbit Antine E; Tsien Roger Y; McCulloch Andrew D
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(34):12923-8.
2006: Shu Xiaokun; Shaner Nathan C; Yarbrough Corinne A; Tsien Roger Y; Remington S James
Novel chromophores and buried charges control color in mFruits.
Biochemistry 2006;45(32):9639-47.
2006: Palmer Amy E; Giacomello Marta; Kortemme Tanja; Hires S Andrew; Lev-Ram Varda; Baker David; Tsien Roger Y
Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs.
Chemistry & biology 2006;13(5):521-30.
2006: Babendure Jeremy R; Babendure Jennie L; Ding Jian-Hua; Tsien Roger Y
Control of mammalian translation by mRNA structure near caps.
RNA (New York, N.Y.) 2006;12(5):851-61.
2006: Giepmans Ben N G; Adams Stephen R; Ellisman Mark H; Tsien Roger Y
The fluorescent toolbox for assessing protein location and function.
Science (New York, N.Y.) 2006;312(5771):217-24.
2006: Sun Mingxuan; Oakes Judy L; Ananthanarayanan Shobana K; Hawley Katherine H; Tsien Roger Y; Adams Stephen R; Yengo Christopher M
Dynamics of the upper 50-kDa domain of myosin V examined with fluorescence resonance energy transfer.
The Journal of biological chemistry 2006;281(9):5711-7.
2006: Wang Lei; Tsien Roger Y
Evolving proteins in mammalian cells using somatic hypermutation.
Nature protocols 2006;1(3):1346-50.
2006: Palmer Amy E; Tsien Roger Y
Measuring calcium signaling using genetically targetable fluorescent indicators.
Nature protocols 2006;1(3):1057-65.
2006: Zacharias David A; Tsien Roger Y
Molecular biology and mutation of green fluorescent protein.
Methods of biochemical analysis 2006;47():83-120.
2005: Shaner Nathan C; Steinbach Paul A; Tsien Roger Y
A guide to choosing fluorescent proteins.
Nature methods 2005;2(12):905-9.
2005: Martin Brent R; Giepmans Ben N G; Adams Stephen R; Tsien Roger Y
Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity.
Nature biotechnology 2005;23(10):1308-14.
2005: Zhang Jin; Hupfeld Christopher J; Taylor Susan S; Olefsky Jerrold M; Tsien Roger Y
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes.
Nature 2005;437(7058):569-73.
2005: Goldstein J C; Muñoz-Pinedo C; Ricci J-E; Adams S R; Kelekar A; Schuler M; Tsien R Y; Green D R
Cytochrome c is released in a single step during apoptosis.
Cell death and differentiation 2005;12(5):453-62.
2005: Wang Yingxiao; Botvinick Elliot L; Zhao Yihua; Berns Michael W; Usami Shunichi; Tsien Roger Y; Chien Shu
Visualizing the mechanical activation of Src.
Nature 2005;434(7036):1040-5.
2005: Hoffmann Carsten; Gaietta Guido; Bünemann Moritz; Adams Stephen R; Oberdorff-Maass Silke; Behr Björn; Vilardaga Jean-Pierre; Tsien Roger Y; Ellisman Mark H; Lohse Martin J
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells.
Nature methods 2005;2(3):171-6.
2005: Tsien Roger Y
Building and breeding molecules to spy on cells and tumors.
FEBS letters 2005;579(4):927-32.
2005: Kunkel Maya T; Ni Qiang; Tsien Roger Y; Zhang Jin; Newton Alexandra C
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.
The Journal of biological chemistry 2005;280(7):5581-7.
2004: Jiang Tao; Olson Emilia S; Nguyen Quyen T; Roy Melinda; Jennings Patricia A; Tsien Roger Y
Tumor imaging by means of proteolytic activation of cell-penetrating peptides.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17867-72.
2004: Palmer Amy E; Jin Can; Reed John C; Tsien Roger Y
Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17404-9.
2004: Shaner Nathan C; Campbell Robert E; Steinbach Paul A; Giepmans Ben N G; Palmer Amy E; Tsien Roger Y
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein.
Nature biotechnology 2004;22(12):1567-72.
2004: Wang Lei; Jackson W Coyt; Steinbach Paul A; Tsien Roger Y
Evolution of new nonantibody proteins via iterative somatic hypermutation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16745-9.
2004: Chae Han-Jung; Kim Hyung-Ryong; Xu Chunyan; Bailly-Maitre Beatrice; Krajewska Maryla; Krajewski Stan; Banares Steven; Cui Janice; Digicaylioglu Murat; Ke Ning; Kitada Shinichi; Monosov Edward; Thomas Michael; Kress Christina L; Babendure Jeremy R; Tsien Roger Y; Lipton Stuart A; Reed John C
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.
Molecular cell 2004;15(3):355-66.
2004: Furuta Toshiaki; Takeuchi Hiroko; Isozaki Masahiro; Takahashi Yasuhiro; Kanehara Makoto; Sugimoto Masazumi; Watanabe Takayoshi; Noguchi Kousei; Dore Timothy M; Kurahashi Takashi; Iwamura Michiko; Tsien Roger Y
Bhc-cNMPs as either water-soluble or membrane-permeant photoreleasable cyclic nucleotides for both one- and two-photon excitation.
Chembiochem : a European journal of chemical biology 2004;5(8):1119-28.
2004: Hasan Mazahir T; Friedrich Rainer W; Euler Thomas; Larkum Matthew E; Giese Günter; Both Matthias; Duebel Jens; Waters Jack; Bujard Hermann; Griesbeck Oliver; Tsien Roger Y; Nagai Takeharu; Miyawaki Atsushi; Denk Winfried
Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control.
PLoS biology 2004;2(6):e163.
2004: Dooley Colette T; Dore Timothy M; Hanson George T; Jackson W Coyt; Remington S James; Tsien Roger Y
Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators.
The Journal of biological chemistry 2004;279(21):22284-93.
2004: Ju William; Morishita Wade; Tsui Jennifer; Gaietta Guido; Deerinck Thomas J; Adams Stephen R; Garner Craig C; Tsien Roger Y; Ellisman Mark H; Malenka Robert C
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors.
Nature neuroscience 2004;7(3):244-53.
2004: Hanson George T; Aggeler Robert; Oglesbee Devin; Cannon Mark; Capaldi Roderick A; Tsien Roger Y; Remington S James
Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators.
The Journal of biological chemistry 2004;279(13):13044-53.
2004: Ray Pritha; De Abhijit; Min Jung-Jun; Tsien Roger Y; Gambhir Sanjiv S
Imaging tri-fusion multimodality reporter gene expression in living subjects.
Cancer research 2004;64(4):1323-30.
2003: Lev-Ram Varda; Mehta Samar B; Kleinfeld David; Tsien Roger Y
Reversing cerebellar long-term depression.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15989-93.
2003: Hasegawa Sumitaka; Jackson W Coyt; Tsien Roger Y; Rao Jianghong
Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14892-6.
2003: Babendure Jeremy R; Adams Stephen R; Tsien Roger Y
Aptamers switch on fluorescence of triphenylmethane dyes.
Journal of the American Chemical Society 2003;125(48):14716-7.
2003: Tour Oded; Meijer Rene M; Zacharias David A; Adams Stephen R; Tsien Roger Y
Genetically targeted chromophore-assisted light inactivation.
Nature biotechnology 2003;21(12):1505-8.
2003: Gao Wenzhong; Xing Bengang; Tsien Roger Y; Rao Jianghong
Novel fluorogenic substrates for imaging beta-lactamase gene expression.
Journal of the American Chemical Society 2003;125(37):11146-7.
2003: Tsien Roger Y
Imagining imaging's future.
Nature reviews. Molecular cell biology 2003;Suppl():SS16-21.
2003: Sosinsky Gina E; Gaietta Guido M; Hand Galen; Deerinck Thomas J; Han Areum; Mackey Mason; Adams Stephen R; Bouwer James; Tsien Roger Y; Ellisman Mark H
Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics.
Cell communication & adhesion 2003;10(4-6):181-6.
2003: Tsai Philbert S; Friedman Beth; Ifarraguerri Agustin I; Thompson Beverly D; Lev-Ram Varda; Schaffer Chris B; Xiong Qing; Tsien Roger Y; Squier Jeffrey A; Kleinfeld David
All-optical histology using ultrashort laser pulses.
Neuron 2003;39(1):27-41.
2003: Violin Jonathan D; Zhang Jin; Tsien Roger Y; Newton Alexandra C
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C.
The Journal of cell biology 2003;161(5):899-909.
2003: Yu Dinghui; Baird Geoffrey S; Tsien Roger Y; Davis Ronald L
Detection of calcium transients in Drosophila mushroom body neurons with camgaroo reporters.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(1):64-72.
2003: Tsien Roger Y
Breeding molecules to spy on cells.
Harvey lectures 2003;99():77-93.
2002: Gilman Alfred G; Simon Melvin I; Bourne Henry R; Harris Bruce A; Long Rochelle; Ross Elliott M; Stull James T; Taussig Ronald; Bourne Henry R; Arkin Adam P; Cobb Melanie H; Cyster Jason G; Devreotes Peter N; Ferrell James E; Fruman David; Gold Michael; Weiss Arthur; Stull James T; Berridge Michael J; Cantley Lewis C; Catterall William A; Coughlin Shaun R; Olson Eric N; Smith Temple F; Brugge Joan S; Botstein David; Dixon Jack E; Hunter Tony; Lefkowitz Robert J; Pawson Anthony J; Sternberg Paul W; Varmus Harold; Subramaniam Shankar; Sinkovits Robert S; Li Joshua; Mock Dennis; Ning Yuhong; Saunders Brian; Sternweis Paul C; Hilgemann Donald; Scheuermann Richard H; DeCamp Dianne; Hsueh Robert; Lin Keng-Mean; Ni Yan; Seaman William E; Simpson Paul C; O'Connell Timothy D; Roach Tamara; Simon Melvin I; Choi Sangdun; Eversole-Cire Pamela; Fraser Iain; Mumby Marc C; Zhao Yingming; Brekken Deirdre; Shu Hongjun; Meyer Tobias; Chandy Grischa; Heo Won Do; Liou Jen; O'Rourke Nancy; Verghese Mary; Mumby Susanne M; Han Heping; Brown H Alex; Forrester Jeffrey S; Ivanova Pavlina; Milne Stephen B; Casey Patrick J; Harden T Kendall; Arkin Adam P; Doyle John; Gray Martha L; Meyer Tobias; Michnick Stephen; Schmidt Martin A; Toner Mehmet; Tsien Roger Y; Natarajan Madhusudan; Ranganathan Rama; Sambrano Gilberto R;
Overview of the Alliance for Cellular Signaling.
Nature 2002;420(6916):703-6.
2002: Zhang Jin; Campbell Robert E; Ting Alice Y; Tsien Roger Y
Creating new fluorescent probes for cell biology.
Nature reviews. Molecular cell biology 2002;3(12):906-18.
2002: Campbell Robert E; Tour Oded; Palmer Amy E; Steinbach Paul A; Baird Geoffrey S; Zacharias David A; Tsien Roger Y
A monomeric red fluorescent protein.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):7877-82.
2002: Lev-Ram Varda; Wong Scott T; Storm Daniel R; Tsien Roger Y
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8389-93.
2002: Adams Stephen R; Campbell Robert E; Gross Larry A; Martin Brent R; Walkup Grant K; Yao Yong; Llopis Juan; Tsien Roger Y
New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications.
Journal of the American Chemical Society 2002;124(21):6063-76.
2002: Zacharias David A; Violin Jonathan D; Newton Alexandra C; Tsien Roger Y
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells.
Science (New York, N.Y.) 2002;296(5569):913-6.
2002: Gaietta Guido; Deerinck Thomas J; Adams Stephen R; Bouwer James; Tour Oded; Laird Dale W; Sosinsky Gina E; Tsien Roger Y; Ellisman Mark H
Multicolor and electron microscopic imaging of connexin trafficking.
Science (New York, N.Y.) 2002;296(5567):503-7.
2001: Ting A Y; Kain K H; Klemke R L; Tsien R Y
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15003-8.
2001: Zhang J; Ma Y; Taylor S S; Tsien R Y
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14997-5002.
2001: Chan F K; Siegel R M; Zacharias D; Swofford R; Holmes K L; Tsien R Y; Lenardo M J
Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein.
Cytometry 2001;44(4):361-8.
2001: Burdette S C; Walkup G K; Spingler B; Tsien R Y; Lippard S J
Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution.
Journal of the American Chemical Society 2001;123(32):7831-41.
2001: Ando H; Furuta T; Tsien R Y; Okamoto H
Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos.
Nature genetics 2001;28(4):317-25.
2001: Wu M M; Grabe M; Adams S; Tsien R Y; Moore H P; Machen T E
Mechanisms of pH regulation in the regulated secretory pathway.
The Journal of biological chemistry 2001;276(35):33027-35.
2001: Griesbeck O; Baird G S; Campbell R E; Zacharias D A; Tsien R Y
Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications.
The Journal of biological chemistry 2001;276(31):29188-94.
2001: Honda A; Adams S R; Sawyer C L; Lev-Ram V; Tsien R Y; Dostmann W R
Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2437-42.
2000: Kapahi P; Takahashi T; Natoli G; Adams S R; Chen Y; Tsien R Y; Karin M
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase.
The Journal of biological chemistry 2000;275(46):36062-6.
2000: Heikal A A; Hess S T; Baird G S; Tsien R Y; Webb W W
Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine).
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11996-2001.
2000: Gross L A; Baird G S; Hoffman R C; Baldridge K K; Tsien R Y
The structure of the chromophore within DsRed, a red fluorescent protein from coral.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11990-5.
2000: Baird G S; Zacharias D A; Tsien R Y
Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11984-9.
2000: Allen G J; Chu S P; Schumacher K; Shimazaki C T; Vafeados D; Kemper A; Hawke S D; Tallman G; Tsien R Y; Harper J F; Chory J; Schroeder J I
Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant.
Science (New York, N.Y.) 2000;289(5488):2338-42.
2000: Siegel R M; Chan F K; Zacharias D A; Swofford R; Holmes K L; Tsien R Y; Lenardo M J
Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein.
Science's STKE : signal transduction knowledge environment 2000;2000(38):pl1.
2000: Kerr R; Lev-Ram V; Baird G; Vincent P; Tsien R Y; Schafer W R
Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans.
Neuron 2000;26(3):583-94.
2000: Siegel R M; Frederiksen J K; Zacharias D A; Chan F K; Johnson M; Lynch D; Tsien R Y; Lenardo M J
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.
Science (New York, N.Y.) 2000;288(5475):2354-7.
2000: Matsuyama S; Llopis J; Deveraux Q L; Tsien R Y; Reed J C
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis.
Nature cell biology 2000;2(6):318-25.
2000: Zacharias D A; Baird G S; Tsien R Y
Recent advances in technology for measuring and manipulating cell signals.
Current opinion in neurobiology 2000;10(3):416-21.
2000: Llopis J; Westin S; Ricote M; Wang Z; Cho C Y; Kurokawa R; Mullen T M; Rose D W; Rosenfeld M G; Tsien R Y; Glass C K;
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4363-8.
2000: Wu M M; Llopis J; Adams S; McCaffery J M; Kulomaa M S; Machen T E; Moore H P; Tsien R Y
Organelle pH studies using targeted avidin and fluorescein-biotin.
Chemistry & biology 2000;7(3):197-209.
2000: Thomas D; Lipp P; Tovey S C; Berridge M J; Li W; Tsien R Y; Bootman M D
Microscopic properties of elementary Ca2+ release sites in non-excitable cells.
Current biology : CB 2000;10(1):8-15.
2000: Zaccolo M; De Giorgi F; Cho C Y; Feng L; Knapp T; Negulescu P A; Taylor S S; Tsien R Y; Pozzan T
A genetically encoded, fluorescent indicator for cyclic AMP in living cells.
Nature cell biology 2000;2(1):25-9.
2000: Griffin B A; Adams S R; Jones J; Tsien R Y
Fluorescent labeling of recombinant proteins in living cells with FlAsH.
Methods in enzymology 2000;327():565-78.
2000: Wu M M; Llopis J; Adams S R; McCaffery J M; Teter K; Kulomaa M S; Machen T E; Moore H P; Tsien R Y
Studying organelle physiology with fusion protein-targeted avidin and fluorescent biotin conjugates.
Methods in enzymology 2000;327():546-64.
2000: Miyawaki A; Tsien R Y
Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein.
Methods in enzymology 2000;327():472-500.
1999: Tsien R Y
Rosy dawn for fluorescent proteins.
Nature biotechnology 1999;17(10):956-7.
1999: Allen G J; Kwak J M; Chu S P; Llopis J; Tsien R Y; Harper J F; Schroeder J I
Cameleon calcium indicator reports cytoplasmic calcium dynamics in Arabidopsis guard cells.
The Plant journal : for cell and molecular biology 1999;19(6):735-47.
1999: Baird G S; Zacharias D A; Tsien R Y
Circular permutation and receptor insertion within green fluorescent proteins.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11241-6.
1999: Yao Y; Ferrer-Montiel A V; Montal M; Tsien R Y
Activation of store-operated Ca2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger.
Cell 1999;98(4):475-85.
1999: Cacciatore T W; Brodfuehrer P D; Gonzalez J E; Jiang T; Adams S R; Tsien R Y; Kristan W B; Kleinfeld D
Identification of neural circuits by imaging coherent electrical activity with FRET-based dyes.
Neuron 1999;23(3):449-59.
1999: Fan G Y; Fujisaki H; Miyawaki A; Tsay R K; Tsien R Y; Ellisman M H
Video-rate scanning two-photon excitation fluorescence microscopy and ratio imaging with cameleons.
Biophysical journal 1999;76(5):2412-20.
1999: Li C J; Heim R; Lu P; Pu Y; Tsien R Y; Chang D C
Dynamic redistribution of calmodulin in HeLa cells during cell division as revealed by a GFP-calmodulin fusion protein technique.
Journal of cell science 1999;112 ( Pt 10)():1567-77.
1999: Lin P; Yao Y; Hofmeister R; Tsien R Y; Farquhar M G
Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi.
The Journal of cell biology 1999;145(2):279-89.
1999: Miyawaki A; Griesbeck O; Heim R; Tsien R Y
Dynamic and quantitative Ca2+ measurements using improved cameleons.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2135-40.
1999: Furuta T; Wang S S; Dantzker J L; Dore T M; Bybee W J; Callaway E M; Denk W; Tsien R Y
Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1193-200.
1999: Brown E B; Shear J B; Adams S R; Tsien R Y; Webb W W
Photolysis of caged calcium in femtoliter volumes using two-photon excitation.
Biophysical journal 1999;76(1 Pt 1):489-99.
1998: Raz E; Zlokarnik G; Tsien R Y; Driever W
beta-lactamase as a marker for gene expression in live zebrafish embryos.
Developmental biology 1998;203(2):290-4.
1998: Griffin B A; Adams S R; Tsien R Y
Specific covalent labeling of recombinant protein molecules inside live cells.
Science (New York, N.Y.) 1998;281(5374):269-72.
1998: Tsien R Y; Miyawaki A
Seeing the machinery of live cells.
Science (New York, N.Y.) 1998;280(5371):1954-5.
1998: Llopis J; McCaffery J M; Miyawaki A; Farquhar M G; Tsien R Y
Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6803-8.
1998: Jiang T; Sweeney G; Rudolf M T; Klip A; Traynor-Kaplan A; Tsien R Y
Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate.
The Journal of biological chemistry 1998;273(18):11017-24.
1998: Li W; Llopis J; Whitney M; Zlokarnik G; Tsien R Y
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression.
Nature 1998;392(6679):936-41.
1998: Zlokarnik G; Negulescu P A; Knapp T E; Mere L; Burres N; Feng L; Whitney M; Roemer K; Tsien R Y
Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter.
Science (New York, N.Y.) 1998;279(5347):84-8.
1998: Tsien R Y
The green fluorescent protein.
Annual review of biochemistry 1998;67():509-44.
1997: Eckmann L; Rudolf M T; Ptasznik A; Schultz C; Jiang T; Wolfson N; Tsien R; Fierer J; Shears S B; Kagnoff M F; Traynor-Kaplan A E
D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14456-60.
1997: Adams S R; Lev-Ram V; Tsien R Y
A new caged Ca2+, azid-1, is far more photosensitive than nitrobenzyl-based chelators.
Chemistry & biology 1997;4(11):867-78.
1997: Miyawaki A; Llopis J; Heim R; McCaffery J M; Adams J A; Ikura M; Tsien R Y
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin.
Nature 1997;388(6645):882-7.
1997: Wachter R M; King B A; Heim R; Kallio K; Tsien R Y; Boxer S G; Remington S J
Crystal structure and photodynamic behavior of the blue emission variant Y66H/Y145F of green fluorescent protein.
Biochemistry 1997;36(32):9759-65.
1997: Dickson R M; Cubitt A B; Tsien R Y; Moerner W E
On/off blinking and switching behaviour of single molecules of green fluorescent protein.
Nature 1997;388(6640):355-8.
1997: Yao Y; Tsien R Y
Calcium current activated by depletion of calcium stores in Xenopus oocytes.
The Journal of general physiology 1997;109(6):703-15.
1997: Lev-Ram V; Jiang T; Wood J; Lawrence D S; Tsien R Y
Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellar long-term depression.
Neuron 1997;18(6):1025-38.
1997: Lev-Ram V; Nebyelul Z; Ellisman M H; Huang P L; Tsien R Y
Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase.
Learning & memory (Cold Spring Harbor, N.Y.) 1997;4(1):169-77.
1997: González J E; Tsien R Y
Improved indicators of cell membrane potential that use fluorescence resonance energy transfer.
Chemistry & biology 1997;4(4):269-77.
1997: Brejc K; Sixma T K; Kitts P A; Kain S R; Tsien R Y; Ormö M; Remington S J
Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2306-11.
1996: Arancio O; Kiebler M; Lee C J; Lev-Ram V; Tsien R Y; Kandel E R; Hawkins R D
Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons.
Cell 1996;87(6):1025-35.
1996: Hempel C M; Vincent P; Adams S R; Tsien R Y; Selverston A I
Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuitm.
Nature 1996;384(6605):166-9.
1996: Scheenen W J; Makings L R; Gross L R; Pozzan T; Tsien R Y
Photodegradation of indo-1 and its effect on apparent Ca2+ concentrations.
Chemistry & biology 1996;3(9):765-74.
1996: Ormö M; Cubitt A B; Kallio K; Gross L A; Tsien R Y; Remington S J
Crystal structure of the Aequorea victoria green fluorescent protein.
Science (New York, N.Y.) 1996;273(5280):1392-5.
1996: Rizzuto R; Brini M; De Giorgi F; Rossi R; Heim R; Tsien R Y; Pozzan T
Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo.
Current biology : CB 1996;6(2):183-8.
1996: Heim R; Tsien R Y
Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer.
Current biology : CB 1996;6(2):178-82.
1996: Arancio O; Lev-Ram V; Tsien R Y; Kandel E R; Hawkins R D
Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons.
Journal of physiology, Paris 1996;90(5-6):321-2.
1995: Cubitt A B; Heim R; Adams S R; Boyd A E; Gross L A; Tsien R Y
Understanding, improving and using green fluorescent proteins.
Trends in biochemical sciences 1995;20(11):448-55.
1995: González J E; Tsien R Y
Voltage sensing by fluorescence resonance energy transfer in single cells.
Biophysical journal 1995;69(4):1272-80.
1995: Lev-Ram V; Makings L R; Keitz P F; Kao J P; Tsien R Y
Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients.
Neuron 1995;15(2):407-15.
1995: Wen W; Meinkoth J L; Tsien R Y; Taylor S S
Identification of a signal for rapid export of proteins from the nucleus.
Cell 1995;82(3):463-73.
1995: Vajanaphanich M; Schultz C; Tsien R Y; Traynor-Kaplan A E; Pandol S J; Barrett K E
Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells.
The Journal of clinical investigation 1995;96(1):386-93.
1995: Heim R; Cubitt A B; Tsien R Y
Improved green fluorescence.
Nature 1995;373(6516):663-4.
1995: Bacskai B J; Wallén P; Lev-Ram V; Grillner S; Tsien R Y
Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy.
Neuron 1995;14(1):19-28.
1995: Randriamampita C; Tsien R Y
Degradation of a calcium influx factor (CIF) can be blocked by phosphatase inhibitors or chelation of Ca2+.
The Journal of biological chemistry 1995;270(1):29-32.
1994: Heim R; Prasher D C; Tsien R Y
Wavelength mutations and posttranslational autoxidation of green fluorescent protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12501-4.
1994: Wen W; Harootunian A T; Adams S R; Feramisco J; Tsien R Y; Meinkoth J L; Taylor S S
Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal.
The Journal of biological chemistry 1994;269(51):32214-20.
1994: Schultz C; Vajanaphanich M; Genieser H G; Jastorff B; Barrett K E; Tsien R Y
Membrane-permeant derivatives of cyclic AMP optimized for high potency, prolonged activity, or rapid reversibility.
Molecular pharmacology 1994;46(4):702-8.
1994: Ranganathan R; Bacskai B J; Tsien R Y; Zuker C S
Cytosolic calcium transients: spatial localization and role in Drosophila photoreceptor cell function.
Neuron 1994;13(4):837-48.
1994: Vajanaphanich M; Schultz C; Rudolf M T; Wasserman M; Enyedi P; Craxton A; Shears S B; Tsien R Y; Barrett K E; Traynor-Kaplan A
Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4.
Nature 1994;371(6499):711-4.
1994: Civitelli R; Bacskai B J; Mahaut-Smith M P; Adams S R; Avioli L V; Tsien R Y
Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(9):1407-17.
1994: Deerinck T J; Martone M E; Lev-Ram V; Green D P; Tsien R Y; Spector D L; Huang S; Ellisman M H
Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy.
The Journal of cell biology 1994;126(4):901-10.
1994: Gurantz D; Harootunian A T; Tsien R Y; Dionne V E; Margiotta J F
VIP modulates neuronal nicotinic acetylcholine receptor function by a cyclic AMP-dependent mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(6):3540-7.
1994: Asmis R; Randriamampita C; Tsien R Y; Dennis E A
Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells.
The Biochemical journal 1994;298 Pt 3():543-51.
1994: Makings L R; Tsien R Y
Caged nitric oxide. Stable organic molecules from which nitric oxide can be photoreleased.
The Journal of biological chemistry 1994;269(9):6282-5.
1994: Fantozzi D A; Harootunian A T; Wen W; Taylor S S; Feramisco J R; Tsien R Y; Meinkoth J L
Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus.
The Journal of biological chemistry 1994;269(4):2676-86.
1993: Harootunian A T; Adams S R; Wen W; Meinkoth J L; Taylor S S; Tsien R Y
Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion.
Molecular biology of the cell 1993;4(10):993-1002.
1993: Randriamampita C; Tsien R Y
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx.
Nature 1993;364(6440):809-14.
1993: Hagiwara M; Brindle P; Harootunian A; Armstrong R; Rivier J; Vale W; Tsien R; Montminy M R
Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.
Molecular and cellular biology 1993;13(8):4852-9.
1993: Tsien R Y; Bacskai B J; Adams S R
FRET for studying intracellular signalling.
Trends in cell biology 1993;3(7):242-5.
1993: LaMorte V J; Harootunian A T; Spiegel A M; Tsien R Y; Feramisco J R
Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2.
The Journal of cell biology 1993;121(1):91-9.
1993: Bacskai B J; Hochner B; Mahaut-Smith M; Adams S R; Kaang B K; Kandel E R; Tsien R Y
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.
Science (New York, N.Y.) 1993;260(5105):222-6.
1993: Schultz C; Vajanaphanich M; Harootunian A T; Sammak P J; Barrett K E; Tsien R Y
Acetoxymethyl esters of phosphates, enhancement of the permeability and potency of cAMP.
The Journal of biological chemistry 1993;268(9):6316-22.
1993: Adams S R; Tsien R Y
Controlling cell chemistry with caged compounds.
Annual review of physiology 1993;55():755-84.
1993: Adams S; Bacskai B; Harootunian A T; Mahaut-Smith M; Sammak P J; Taylor S S; Tsien R Y
Imaging of cAMP signals and A-kinase translocation in single living cells.
Advances in second messenger and phosphoprotein research 1993;28():167-70.
1993: Adams S R; Bacskai B J; Hochner B; Kaang B K; Kandel E R; Mahaut-Smith M; Tsien R Y
Confocal imaging of cAMP signals in Aplysia neurons.
The Japanese journal of physiology 1993;43 Suppl 1():S91-3.
1992: Tsien R Y
Intracellular signal transduction in four dimensions: from molecular design to physiology.
The American journal of physiology 1992;263(4 Pt 1):C723-8.
1992: Sammak P J; Adams S R; Harootunian A T; Schliwa M; Tsien R Y
Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging.
The Journal of cell biology 1992;117(1):57-72.
1991: Adams S R; Harootunian A T; Buechler Y J; Taylor S S; Tsien R Y
Fluorescence ratio imaging of cyclic AMP in single cells.
Nature 1991;349(6311):694-7.
1991: Harootunian A T; Kao J P; Paranjape S; Adams S R; Potter B V; Tsien R Y
Cytosolic Ca2+ oscillations in REF52 fibroblasts: Ca(2+)-stimulated IP3 production or voltage-dependent Ca2+ channels as key positive feedback elements.
Cell calcium 1991;12(2-3):153-64.
1991: Harootunian A T; Kao J P; Paranjape S; Tsien R Y
Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3.
Science (New York, N.Y.) 1991;251(4989):75-8.
1990: Kao J P; Alderton J M; Tsien R Y; Steinhardt R A
Active involvement of Ca2+ in mitotic progression of Swiss 3T3 fibroblasts.
The Journal of cell biology 1990;111(1):183-96.
1990: Tsien R Y; Harootunian A T
Practical design criteria for a dynamic ratio imaging system.
Cell calcium 1990;11(2-3):93-109.
1990: Negulescu P A; Harootunian A; Tsien R Y; Machen T E
Fluorescence measurements of cytosolic free Na concentration, influx and efflux in gastric cells.
Cell regulation 1990;1(3):259-68.
1990: Tsien R W; Tsien R Y
Calcium channels, stores, and oscillations.
Annual review of cell biology 1990;6():715-60.
1990: Harootunian A T; Kao J P; Adams S R; Tsien R Y
Imaging and manipulation of cytosolic ions and messengers during cell activation.
Journal of cell science. Supplement 1990;13():1-4.
1989: Minta A; Tsien R Y
Fluorescent indicators for cytosolic sodium.
The Journal of biological chemistry 1989;264(32):19449-57.
1989: Harootunian A T; Kao J P; Eckert B K; Tsien R Y
Fluorescence ratio imaging of cytosolic free Na+ in individual fibroblasts and lymphocytes.
The Journal of biological chemistry 1989;264(32):19458-67.
1989: Kawanishi T; Blank L M; Harootunian A T; Smith M T; Tsien R Y
Ca2+ oscillations induced by hormonal stimulation of individual fura-2-loaded hepatocytes.
The Journal of biological chemistry 1989;264(22):12859-66.
1989: Kao J P; Harootunian A T; Tsien R Y
Photochemically generated cytosolic calcium pulses and their detection by fluo-3.
The Journal of biological chemistry 1989;264(14):8179-84.
1989: Minta A; Kao J P; Tsien R Y
Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores.
The Journal of biological chemistry 1989;264(14):8171-8.
1989: Havran W L; Poenie M; Tigelaar R E; Tsien R Y; Allison J P
Phenotypic and functional analysis of gamma delta T cell receptor-positive murine dendritic epidermal clones.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(5):1422-8.
1989: Tsien R Y
Fluorescence ratio imaging of dynamic intracellular signals.
Acta physiologica Scandinavica. Supplementum 1989;582():6.
1989: Tsien R; Pozzan T
Measurement of cytosolic free Ca2+ with quin2.
Methods in enzymology 1989;172():230-62.
1989: Tsien R Y
Fluorescent probes of cell signaling.
Annual review of neuroscience 1989;12():227-53.
1989: Tsien R Y
Fluorescent indicators of ion concentrations.
Methods in cell biology 1989;30():127-56.
1988: Tsien R Y
Fluorescence measurement and photochemical manipulation of cytosolic free calcium.
Trends in neurosciences 1988;11(10):419-24.
1988: Ratto G M; Payne R; Owen W G; Tsien R Y
The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(9):3240-6.
1988: Lipscombe D; Madison D V; Poenie M; Reuter H; Tsien R W; Tsien R Y
Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons.
Neuron 1988;1(5):355-65.
1988: Kao J P; Tsien R Y
Ca2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements.
Biophysical journal 1988;53(4):635-9.
1988: Lipscombe D; Madison D V; Poenie M; Reuter H; Tsien R Y; Tsien R W
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2398-402.
1988: Ambler S K; Poenie M; Tsien R Y; Taylor P
Agonist-stimulated oscillations and cycling of intracellular free calcium in individual cultured muscle cells.
The Journal of biological chemistry 1988;263(4):1952-9.
1988: Harootunian A T; Kao J P; Tsien R Y
Agonist-induced calcium oscillations in depolarized fibroblasts and their manipulation by photoreleased Ins(1,4,5)P3, Ca++, and Ca++ buffer.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():935-43.
1988: Langlet C; Guimezanes A; Kaldy P; Boyer C; Buferne M; Poenie M; Tsien R; Leo O; Bluestone J; Leserman L
Role of Ti/CD3, Thy-1, and Ly-6 in cytolytic T-cell activation analyzed with Ti loss variants.
Annals of the New York Academy of Sciences 1988;532():33-43.
1987: Havran W L; Poenie M; Kimura J; Tsien R; Weiss A; Allison J P
Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes.
Nature 1987;330(6144):170-3.
1987: Poenie M; Tsien R Y; Schmitt-Verhulst A M
Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets.
The EMBO journal 1987;6(8):2223-32.
1987: Chen W S; Lazar C S; Poenie M; Tsien R Y; Gill G N; Rosenfeld M G
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor.
Nature 1987;328(6133):820-3.
1987: Wilson H A; Greenblatt D; Poenie M; Finkelman F D; Tsien R Y
Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium.
The Journal of experimental medicine 1987;166(2):601-6.
1987: Chused T M; Wilson H A; Greenblatt D; Ishida Y; Edison L J; Tsien R Y; Finkelman F D
Flow cytometric analysis of murine splenic B lymphocyte cytosolic free calcium response to anti-IgM and anti-IgD.
Cytometry 1987;8(4):396-404.
1987: Paradiso A M; Tsien R Y; Demarest J R; Machen T E
Na-H and Cl-HCO3 exchange in rabbit oxyntic cells using fluorescence microscopy.
The American journal of physiology 1987;253(1 Pt 1):C30-6.
1987: Gurney A M; Tsien R Y; Lester H A
Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(10):3496-500.
1987: Wilson H A; Greenblatt D; Taylor C W; Putney J W; Tsien R Y; Finkelman F D; Chused T M
The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fc gamma receptor.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1712-8.
1987: Schmitt-Verhulst A M; Guimezanes A; Boyer C; Poenie M; Tsien R; Buferne M; Hua C; Leserman L
Pleiotropic loss of activation pathways in a T-cell receptor alpha-chain deletion variant of a cytolytic T-cell clone.
Nature 1987;325(6105):628-31.
1987: Paradiso A M; Tsien R Y; Machen T E
Digital image processing of intracellular pH in gastric oxyntic and chief cells.
Nature 1987;325(6103):447-50.
1986: Tsien R Y; Zucker R S
Control of cytoplasmic calcium with photolabile tetracarboxylate 2-nitrobenzhydrol chelators.
Biophysical journal 1986;50(5):843-53.
1986: LaBaer J; Tsien R Y; Fahey K A; DeFranco A L
Stimulation of the antigen receptor on WEHI-231 B lymphoma cells results in a voltage-independent increase in cytoplasmic calcium.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(6):1836-44.
1986: Poenie M; Alderton J; Steinhardt R; Tsien R
Calcium rises abruptly and briefly throughout the cell at the onset of anaphase.
Science (New York, N.Y.) 1986;233(4766):886-9.
1986: Drummond I A; McClure S A; Poenie M; Tsien R Y; Steinhardt R A
Large changes in intracellular pH and calcium observed during heat shock are not responsible for the induction of heat shock proteins in Drosophila melanogaster.
Molecular and cellular biology 1986;6(5):1767-75.
1986: Poenie M; Tsien R
Fura-2: a powerful new tool for measuring and imaging [Ca2+]i in single cells.
Progress in clinical and biological research 1986;210():53-6.
1986: Tsien R Y
New tetracarboxylate chelators for fluorescence measurement and photochemical manipulation of cytosolic free calcium concentrations.
Society of General Physiologists series 1986;40():327-45.
1985: Williams D A; Fogarty K E; Tsien R Y; Fay F S
Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2.
Nature 1985;318(6046):558-61.
1985: Vergara J; Tsien R Y; Delay M
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(18):6352-6.
1985: Poenie M; Alderton J; Tsien R Y; Steinhardt R A
Changes of free calcium levels with stages of the cell division cycle.
Nature 1985;315(6015):147-9.
1985: Tsien R Y; Rink T J; Poenie M
Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths.
Cell calcium 1985;6(1-2):145-57.
1985: Arslan P; Di Virgilio F; Beltrame M; Tsien R Y; Pozzan T
Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+.
The Journal of biological chemistry 1985;260(5):2719-27.
1985: Grynkiewicz G; Poenie M; Tsien R Y
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
The Journal of biological chemistry 1985;260(6):3440-50.
1984: Paradiso A M; Tsien R Y; Machen T E
Na+-H+ exchange in gastric glands as measured with a cytoplasmic-trapped, fluorescent pH indicator.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7436-40.
1984: Meldolesi J; Huttner W B; Tsien R Y; Pozzan T
Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(2):620-4.
1984: Tsien R Y
Measuring and manipulating cytosolic Ca2+ with trapped indicators.
Kroc Foundation series 1984;17():147-55.
1984: Tsien R Y; Pozzan T; Rink T J
Calcium activities and fluxes inside small intact cells as measured with intracellularly trapped chelators.
Advances in cyclic nucleotide and protein phosphorylation research 1984;17():535-41.
1983: Pozzan T; Lew D P; Wollheim C B; Tsien R Y
Is cytosolic ionized calcium regulating neutrophil activation?
Science (New York, N.Y.) 1983;221(4618):1413-5.
1983: Moolenaar W H; Tsien R Y; van der Saag P T; de Laat S W
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts.
Nature 1983;304(5927):645-8.
1983: Tsien R Y
Intracellular measurements of ion activities.
Annual review of biophysics and bioengineering 1983;12():91-116.
1982: Rink T J; Smith S W; Tsien R Y
Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent activation for shape-change and secretion.
FEBS letters 1982;148(1):21-6.
1982: Rink T J; Tsien R Y; Pozzan T
Cytoplasmic pH and free Mg2+ in lymphocytes.
The Journal of cell biology 1982;95(1):189-96.
1982: Rink T J; Tsien R Y
Cytoplasmic free [Ca2+] in very small intact cells.
Biochemical Society transactions 1982;10(4):209.
1982: Tsien R Y; Pozzan T; Rink T J
Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.
The Journal of cell biology 1982;94(2):325-34.
1982: Pozzan T; Arslan P; Tsien R Y; Rink T J
Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes.
The Journal of cell biology 1982;94(2):335-40.
1982: Tsien R Y; Hladky S B
Ion repulsion within membranes.
Biophysical journal 1982;39(1):49-56.
1982: Lew V L; Tsien R Y; Miner C; Bookchin R M
Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator.
Nature 1982;298(5873):478-81.
1982: Tsien R Y; Pozzan T; Rink T J
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes.
Nature 1982;295(5844):68-71.
1981: Tsien R Y; Rink T J
Ca2+-selective electrodes: a novel PVC-gelled neutral carrier mixture compared with other currently available sensors.
Journal of neuroscience methods 1981;4(1):73-86.
1981: Alvarez-Leefmans F J; Rink T J; Tsien R Y
Free calcium ions in neurones of Helix aspersa measured with ion-selective micro-electrodes.
The Journal of physiology 1981;315():531-48.
1981: Tsien R Y
A non-disruptive technique for loading calcium buffers and indicators into cells.
Nature 1981;290(5806):527-8.
1980: Marban E; Rink T J; Tsien R W; Tsien R Y
Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes.
Nature 1980;286(5776):845-50.
1980: Tsien R Y; Rink T J
Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium.
Biochimica et biophysica acta 1980;599(2):623-38.
1980: Tsien R Y
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.
Biochemistry 1980;19(11):2396-404.
1980: Rink T J; Tsien R Y; Warner A E
Free calcium in Xenopus embryos measured with ion-selective microelectrodes.
Nature 1980;283(5748):658-60.
1980: Rink T J; Montecucco C; Hesketh T R; Tsien R Y
Lymphocyte membrane potential assessed with fluorescent probes.
Biochimica et biophysica acta 1980;595(1):15-30.
1978: Tsien R Y
A virial expansion for discrete charges buried in a membrane.
Biophysical journal 1978;24(2):561-7.
1978: Ashley C C; Rink T J; Tsien R Y
Changes in free Ca during muscle contraction, measured with an intracellular Ca-selective electrode [proceedings]
The Journal of physiology 1978;280():27P.
1978: Tsien R Y; Hladky S B
A quantitative resolution of the spectra of a membrane potential indicator, diS-C3-(5), bound to cell components and to red blood cells.
The Journal of membrane biology 1978;38(1-2):73-97.
1975: Tsien R Y; Green D P; Levinson S R; Rudy B; Sanders J K
A pharmacologically active derivative of tetrodotoxin.
Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain) 1975;191(1105):555-9.

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