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Igor Tsigelny

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Physiology

Mutagenesis, Site-Directed

Procedures

Sequence Alignment

Phenomena

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Rats

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Publications

TOP 3
Igor Tsigelny; V L Kouznetsova; M Baitaluk; J-P Changeux
A hierarchical coherent-gene-group model for brain development.
Igor Tsigelny; Jerry P Greenberg; Valentina L Kouznetsova; Christopher A Larson; Mark A Miller; Yuriy Sharikov; Stephen B Howell
An all-atom model of the structure of human copper transporter 1.
Igor Tsigelny; Wolfgang Wrasidlo; Yuriy Sharikov; Brian Spencer; Leslie Crews; Paula Desplats; Tania Gonzalez; Eliezer Masliah
Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.

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All Publications

2013: Igor Tsigelny; V L Kouznetsova; M Baitaluk; J-P Changeux
A hierarchical coherent-gene-group model for brain development.
Genes, brain, and behavior 2013;12(2):147-65.
2012: Igor Tsigelny; Jerry P Greenberg; Valentina L Kouznetsova; Christopher A Larson; Mark A Miller; Yuriy Sharikov; Stephen B Howell
An all-atom model of the structure of human copper transporter 1.
Cell biochemistry and biophysics 2012;63(3):223-34.
2012: Igor Tsigelny; Wolfgang Wrasidlo; Yuriy Sharikov; Brian Spencer; Leslie Crews; Paula Desplats; Tania Gonzalez; Eliezer Masliah
Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.
The FEBS journal 2012;279(6):1000-13.
2011: Igor Tsigelny; Yuriy Sharikov; Oleksii Balinskyi; Vibha Bhatnagar; Valentina L Kouznetsova; Dmytro Kovalskyy; Sanjay K Nigam
Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport.
Cell biochemistry and biophysics 2011;61(2):251-9.
2011: William R Wikoff; Megha Nagle; Valentina L Kouznetsova; Igor Tsigelny; Sanjay K Nigam
Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1).
Journal of proteome research 2011;10(6):2842-51.
2011: Valentina L Kouznetsova; Igor Tsigelny; Megha Nagle; Sanjay K Nigam
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).
Bioorganic & medicinal chemistry 2011;19(11):3320-40.
2010: Seung-Jae Lee; Paula Desplats; Christina Sigurdson; Igor Tsigelny; Eliezer Masliah
Cell-to-cell transmission of non-prion protein aggregates.
Nature reviews. Neurology 2010;6(12):702-6.
2010: Eric A Murphy; David J Shields; Konstantin Stoletov; Elena Dneprovskaia; Michele McElroy; Joshua I Greenberg; Jeff Lindquist; Lisette Acevedo; Sudarshan Anand; Bharat Kumar Majeti; Igor Tsigelny; Adrian Saldanha; Breda Walsh; Robert M Hoffman; Michael Bouvet; Richard L Klemke; Peter K Vogt; Lee Arnold; Wolfgang Wrasidlo; David A Cheresh
Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4299-304.
2010: Yanmei Zhang; Greg Elliot; Adrian Saldanha; Igor Tsigelny; Dennis Carson; Wolf Wrasidlo
Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid.
Beilstein journal of organic chemistry 2010;6():742-7.
2009: Sun-Young Ahn; Satish A Eraly; Igor Tsigelny; Sanjay K Nigam
Interaction of organic cations with organic anion transporters.
The Journal of biological chemistry 2009;284(45):31422-30.
2009: Leslie Crews; Igor Tsigelny; Makoto Hashimoto; Eliezer Masliah
Role of synucleins in Alzheimer's disease.
Neurotoxicity research 2009;16(3):306-17.
2008: Igor Tsigelny; Yuriy Sharikov; Mark A Miller; Eliezer Masliah
Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies.
Nanomedicine : nanotechnology, biology, and medicine 2008;4(4):350-7.
2008: Igor Tsigelny; Jerry Greenberg; Valentina Kouznetsova; Sanjay K Nigam
Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function.
Journal of bioinformatics and computational biology 2008;6(5):885-904.
2008: M Rowland; Igor Tsigelny; M Wolfe; Leo Pezzementi
Inactivation of an invertebrate acetylcholinesterase by sulfhydryl reagents: a reconsideration of the implications for insecticide design.
Chemico-biological interactions 2008;175(1-3):73-5.
2008: Brian Perrin; Melissa Rowland; Matthew Wolfe; Igor Tsigelny; Leo Pezzementi
Thermal denaturation of wild type and mutant recombinant acetylcholinesterase from amphioxus: effects of the temperature of in vitro expression and of reversible inhibitors.
Invertebrate neuroscience : IN 2008;8(3):147-55.
2008: Adam Frederick; Igor Tsigelny; Frances Cohenour; Christopher Spiker; krejci eric; Arnaud Chatonnet; Stefan Bourgoin; Greg Richards; Tessa Allen; Mary H Whitlock; Leo Pezzementi
Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide.
The FEBS journal 2008;275(6):1309-22.
2008: Igor Tsigelny; Leslie Crews; Paula Desplats; Gideon M Shaked; Yuriy Sharikov; Hideya Mizuno; Brian Spencer; Edward Rockenstein; Margarita Trejo; Oleksandr Platoshyn; Jason X-J Yuan; Eliezer Masliah
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.
PloS one 2008;3(9):e3135.
2007: Ying Yu; Oleksandr Platoshyn; Olga Safrina; Igor Tsigelny; Jason X-J Yuan; Steven H Keller
Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).
Biology of the cell / under the auspices of the European Cell Biology Organization 2007;99(8):433-44.
2007: Benjamin D Sachs; George S Baillie; Julianne R McCall; Melissa A Passino; Christian Schachtrup; Derek A Wallace; Allan J Dunlop; Kirsty F MacKenzie; Enno Klussmann; Martin J Lynch; Shoana L Sikorski; Tal Nuriel; Igor Tsigelny; Jin Zhang; Miles D Houslay; Moses V Chao; Katerina Akassoglou
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.
The Journal of cell biology 2007;177(6):1119-32.
2007: Davide Comoletti; Alexander Grishaev; Andrew E Whitten; Igor Tsigelny; Palmer Taylor; Jill Trewhella
Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering.
Structure (London, England : 1993) 2007;15(6):693-705.
2007: Igor Tsigelny; Pazit Bar-On; Yuriy Sharikov; Leslie Crews; Makoto Hashimoto; Mark A Miller; Steven H Keller; Oleksandr Platoshyn; Jason X-J Yuan; Eliezer Masliah
Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein.
The FEBS journal 2007;274(7):1862-77.
2007: Ryan A Adams; Christian Schachtrup; Dimitrios Davalos; Igor Tsigelny; Katerina Akassoglou
Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis.
Current medicinal chemistry 2007;14(27):2925-36.
2006: Todd Talley; Palmer Taylor; Igor Tsigelny; Baldomero M Olivera; Sean B Christensen; Cheryl Dowell; Kyou-Hoon Han; Kwok-Yiu Ho; J Michael McIntosh
Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors.
The Journal of biological chemistry 2006;281(34):24678-86.
2006: Kottayil I Varughese; Igor Tsigelny; Haiyan Zhao
The crystal structure of beryllofluoride Spo0F in complex with the phosphotransferase Spo0B represents a phosphotransfer pretransition state.
Journal of bacteriology 2006;188(13):4970-7.
2006: Melissa Harwell; Melisa D Rowland; Matthew Wolfe; Igor Tsigelny
Inactivation of an invertebrate acetylcholinesterase by sulfhydryl reagents: the roles of two cysteines in the catalytic gorge of the enzyme.
Invertebrate neuroscience : IN 2006;6(2):47-55.
2006: Raj Patel; Rachael Sanders; Lance Brown; Stephanie Baker; Igor Tsigelny; Leo Pezzementi
A tryptophan in the bottleneck of the catalytic gorge of an invertebrate acetylcholinesterase confers relative resistance to carbamate and organophosphate inhibitors.
Cell biochemistry and biophysics 2006;46(3):253-64.
2005: Alexander A Chubykin; Xinran Liu; Davide Comoletti; Igor Tsigelny; Palmer Taylor; Thomas C Südhof
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
The Journal of biological chemistry 2005;280(23):22365-74.
2005: Igor Tsigelny; Douglas Burton; Yuriy Sharikov; Randolph H Hastings; L J Deftos
Coherent expression chromosome cluster analysis reveals differential regulatory functions of amino-terminal and distal parathyroid hormone-related protein domains in prostate carcinoma.
Journal of biomedicine & biotechnology 2005;2005(4):353-63.
2005: Igor Tsigelny; Matthew Hotchko; Jason X-J Yuan; Steven H Keller
Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis.
Cell biochemistry and biophysics 2005;42(1):41-53.
2004: Davide Comoletti; Antonella De Jaco; Lori L Jennings; Robyn E Flynn; Guido Gaietta; Igor Tsigelny; Mark H Ellisman; Palmer Taylor
The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(20):4889-93.
2004: Nicholas E Preece; Minh Nguyen; Manjula Mahata; Sushil K Mahata; Nitish R Mahapatra; Igor Tsigelny; Daniel O'Connor
Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A.
Regulatory peptides 2004;118(1-2):75-87.
2004: Igor Tsigelny; Vladimir Kotlovyi; Linda Wasserman
SNP analysis combined with protein structure prediction defines structure-functional relationships in cancer related cytochrome P450 estrogen metabolism.
Current medicinal chemistry 2004;11(5):525-38.
2004: Ross C Hoffman; Lori L Jennings; Igor Tsigelny; Davide Comoletti; Robyn E Flynn; Thomas C Sudhof; Palmer Taylor
Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry.
Biochemistry 2004;43(6):1496-506.
2004: Igor Tsigelny; Sanjay K Nigam
Complex dynamics of chaperone-protein interactions under cellular stress.
Cell biochemistry and biophysics 2004;40(3):263-76.
2003: Leo Pezzementi; Kimberly Johnson; Igor Tsigelny; Justin Cotney; Elizabeth Manning; Andrew Barker; Sarah Merritt
Amino acids defining the acyl pocket of an invertebrate cholinesterase.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2003;136(4):813-32.
2003: Ganesh S Anand; Dennis Law; Jeffrey G Mandell; Aaron N Snead; Igor Tsigelny; Susan S Taylor; Lynn F Ten Eyck; Elizabeth A Komives
Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13264-9.
2003: Dennis Law; Lynn F Ten Eyck; omer katzenelson; Igor Tsigelny; Victoria A Roberts; Mike E Pique; Julie C Mitchell
Finding needles in haystacks: Reranking DOT results by using shape complementarity, cluster analysis, and biological information.
Proteins 2003;52(1):33-40.
2002: Scott B Hansen; Brian E Molles; Zoran Radic'; Todd Talley; Thomas J Deerinck; Igor Tsigelny; Palmer Taylor
Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein.
The Journal of biological chemistry 2002;277(44):41299-302.
2002: Brian E Molles; Igor Tsigelny; Phuong D Nguyen; Sarah X Gao; Steven M Sine; Palmer Taylor
Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site.
Biochemistry 2002;41(25):7895-906.
2002: Igor Tsigelny; Yuriy Sharikov; Lynn F Ten Eyck
Hidden Markov models-based system (HMMSPECTR) for detecting structural homologies on the basis of sequential information.
Protein engineering 2002;15(5):347-52.
2001: B C Leon; Igor Tsigelny; Joseph A Adams
Electrostatic environment surrounding the activation loop phosphotyrosine in the oncoprotein v-Fps.
Biochemistry 2001;40(34):10078-86.
2001: Jeffrey G Mandell; V A Roberts; Michael E Pique; Vladimir Kotlovyi; Julie C Mitchell; E Nelson; Igor Tsigelny; Lynn F Ten Eyck
Protein docking using continuum electrostatics and geometric fit.
Protein engineering 2001;14(2):105-13.
2000: T J Hirai; Igor Tsigelny; Joseph A Adams
Catalytic assessment of the glycine-rich loop of the v-Fps oncoprotein using site-directed mutagenesis.
Biochemistry 2000;39(43):13276-84.
2000: Palmer Taylor; S Malanz; Brian E Molles; Hitoshi Osaka; Igor Tsigelny
Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure.
Pflügers Archiv : European journal of physiology 2000;440(5 Suppl):R115-7.
2000: Igor Tsigelny; Ilya N Shindyalov; Philip Bourne; Thomas C Südhof; Palmer Taylor
Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations.
Protein science : a publication of the Protein Society 2000;9(1):180-5.
1999: Igor Tsigelny; J P Greenberg; S Cox; William Lee Nichols; Susan S Taylor; Lynn F Ten Eyck
600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase.
Biopolymers 1999;50(5):513-24.
1999: Palmer Taylor; L Wong; Z Radić; Igor Tsigelny; R Brüggemann; NA Hosea; Harvey A Berman
Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity.
Chemico-biological interactions 1999;119-120():3-15.
1998: Igor Tsigelny; Sushil K Mahata; LAURENT TAUPENOT; N E Preece; Manjula Mahata; I Khan; Robert J Parmer; Daniel O'Connor
Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a beta-strand/loop/beta-strand structure secured by hydrophobic interactions and predictive of activity.
Regulatory peptides 1998;77(1-3):43-53.
1998: Elizabeth J Ackermann; E T Ang; Joan R Kanter; Igor Tsigelny; Palmer Taylor
Identification of pairwise interactions in the alpha-neurotoxin-nicotinic acetylcholine receptor complex through double mutant cycles.
The Journal of biological chemistry 1998;273(18):10958-64.
1998: Palmer Taylor; Hitoshi Osaka; Brian E Molles; N Sugiyama; Pascale Marchot; Elizabeth J Ackermann; S Malany; J J McArdle; Steven M Sine; Igor Tsigelny
Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure.
Journal of physiology, Paris 1998;92(2):79-83.
1997: W Hemmer; M McGlone; Igor Tsigelny; Susan S Taylor
Role of the glycine triad in the ATP-binding site of cAMP-dependent protein kinase.
The Journal of biological chemistry 1997;272(27):16946-54.
1997: Igor Tsigelny; N Sugiyama; Steven M Sine; Palmer Taylor
A model of the nicotinic receptor extracellular domain based on sequence identity and residue location.
Biophysical journal 1997;73(1):52-66.
1997: J Lew; N Coruh; Igor Tsigelny; Siv Garrod; Susan S Taylor
Synergistic binding of nucleotides and inhibitors to cAMP-dependent protein kinase examined by acrylodan fluorescence spectroscopy.
The Journal of biological chemistry 1997;272(3):1507-13.
1997: Palmer Taylor; NA Hosea; Igor Tsigelny; Z Radić; Harvey A Berman
Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis.
Enantiomer 1997;2(3-4):249-60.
1996: Igor Tsigelny; Michael E Baker
Structures important in NAD(P)(H) specificity for mammalian retinol and 11-Cis-retinol dehydrogenases.
Biochemical and biophysical research communications 1996;226(1):118-27.
1996: Igor Tsigelny; B D Grant; Susan S Taylor; Lynn F Ten Eyck
Catalytic subunit of cAMP-dependent protein kinase: electrostatic features and peptide recognition.
Biopolymers 1996;39(3):353-65.
1996: N A Hosea; Z Radić; Igor Tsigelny; Harvey A Berman; Daniel M Quinn; Palmer Taylor
Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates.
Biochemistry 1996;35(33):10995-1004.
1996: B D Grant; Igor Tsigelny; JA Adams; Susan S Taylor
Examination of an active-site electrostatic node in the cAMP-dependent protein kinase catalytic subunit.
Protein science : a publication of the Protein Society 1996;5(7):1316-24.
1995: Igor Tsigelny; Michael E Baker
Structures stabilizing the dimer interface on human 11 beta-hydroxysteroid dehydrogenase types 1 and 2 and human 15-hydroxyprostaglandin dehydrogenase and their homologs.
Biochemical and biophysical research communications 1995;217(3):859-68.
1995: Igor Tsigelny; Michael E Baker
Structures important in mammalian 11 beta- and 17 beta-hydroxysteroid dehydrogenases.
The Journal of steroid biochemistry and molecular biology 1995;55(5-6):589-600.
1995: H K van den Born; Z Radić; Pascale Marchot; Palmer Taylor; Igor Tsigelny
Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase.
Protein science : a publication of the Protein Society 1995;4(4):703-15.
1995: Yacov Ashani; Z Radić; Igor Tsigelny; D C Vellom; N A Pickering; Daniel M Quinn; Bhupendra P Doctor; Palmer Taylor
Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes.
The Journal of biological chemistry 1995;270(11):6370-80.
1994: Michel Véron; E Radzio-Andzelm; Igor Tsigelny; S Taylor
Protein kinases share a common structural motif outside the conserved catalytic domain.
Cellular and molecular biology (Noisy-le-Grand, France) 1994;40(5):587-96.
1993: M Veron; E Radzio-Andzelm; Igor Tsigelny; Lynn F Ten Eyck; Susan S Taylor
A conserved helix motif complements the protein kinase core.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10618-22.