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Dimitrios Tsikas

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Dimitrios Tsikas; Anke Böhmer; Helmut Hummler; Hannelore Konrad; Mirja Maassen; Anja Mitschke; Marisa Nacke; Henning Starke; Karina Sutmöller; Norbert Maassen
Even and carbon dioxide independent distribution of nitrite between plasma and erythrocytes of healthy humans at rest.
Dimitrios Tsikas; Alexander A Zoerner; Anke Böhmer; Frank-Mathias Gutzki; Mario Schmidt; Jens Jordan
UPLC-MS/MS measurement of S-nitrosoglutathione (GSNO) in human plasma solves the S-nitrosothiol concentration enigma.
Alexander A Zoerner; Frank-Mathias Gutzki; Jens Jordan; Arslan Arinc Kayacelebi; Christoph Schroeder; Dirk O Stichtenoth; Maria-Theresia Suchy; Jens Tank; Dimitrios Tsikas
A validated, rapid UPLC-MS/MS method for simultaneous ivabradine, reboxetine, and metoprolol analysis in human plasma and its application to clinical trial samples.

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2013: Dimitrios Tsikas; Anke Böhmer; Helmut Hummler; Hannelore Konrad; Mirja Maassen; Anja Mitschke; Marisa Nacke; Henning Starke; Karina Sutmöller; Norbert Maassen
Even and carbon dioxide independent distribution of nitrite between plasma and erythrocytes of healthy humans at rest.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2013;31():31-7.
2013: Dimitrios Tsikas; Alexander A Zoerner; Anke Böhmer; Frank-Mathias Gutzki; Mario Schmidt; Jens Jordan
UPLC-MS/MS measurement of S-nitrosoglutathione (GSNO) in human plasma solves the S-nitrosothiol concentration enigma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2013;927():147-57.
2013: Alexander A Zoerner; Frank-Mathias Gutzki; Jens Jordan; Arslan Arinc Kayacelebi; Christoph Schroeder; Dirk O Stichtenoth; Maria-Theresia Suchy; Jens Tank; Dimitrios Tsikas
A validated, rapid UPLC-MS/MS method for simultaneous ivabradine, reboxetine, and metoprolol analysis in human plasma and its application to clinical trial samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2013;927():105-11.
2013: Anke Böhmer; Stepan Gambaryan; Hartmut H Meyer; Jonas Niemann; Kathrin S Schwedhelm; Dimitrios Tsikas
Potential pitfalls with the use of acetoxy (CH(3)COO) drugs in studies on nitric oxide synthase in platelets.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2013;28():14-6.
2013: Marcus May; Dimitrios Tsikas; Alexander A Zoerner; Sandor Batkai; Jens Jordan; Stefan Engeli
Enhanced human tissue microdialysis using hydroxypropyl-ß-cyclodextrin as molecular carrier.
PloS one 2013;8(4):e60628.
2012: Dimitrios Tsikas
Letter by Tsikas regarding article, "dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase".
Circulation 2012;126(24):e348.
2012: Dimitrios Tsikas
Potential problems and pitfalls with the use of S-nitrosoglutathione and other S-nitrosothiols in physiology-oriented basic science.
The Journal of physiology 2012;590(Pt 23):6247-8; author reply 6249-50.
2012: Daniela Giustarini; Aldo Milzani; Isabella Dalle-Donne; Dimitrios Tsikas; Ranieri Rossi
N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential.
Biochemical pharmacology 2012;84(11):1522-33.
2012: Dimitrios Tsikas
Measurement of nitrite in plasma and serum: still a challenging analytical task.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2012;50(11):2049-51.
2012: Dimitrios Tsikas; Travis T Denton; Christopher E Evans; Frank-Mathias Gutzki; Tetyana Khomenko; Anja Mitschke; John Pinto; Sandor Szabo; Arthur J L Cooper
Stable isotope gas chromatography-tandem mass spectrometry determination of aminoethylcysteine ketimine decarboxylated dimer in biological samples.
Analytical biochemistry 2012;430(1):4-15.
2012: Dimitrios Tsikas; Bibiana Beckmann; Anke Böhmer; Ulrike Dreißigacker; Henning Großkopf; Jens Jordan; Norbert Maassen
Clinical-chemistry laboratory relevant hemolysis is unlikely to compromise human plasma concentration of free asymmetric dimethylarginine (ADMA).
Clinical biochemistry 2012;45(16-17):1536-8.
2012: Dimitrios Tsikas; Maria-Theresia Suchy; Paschalis Tossios; Jürgen C Frölich; Frank-Mathias Gutzki; Jonas Niemann; Sabine Rothmann; Yessica Schneider; Dirk O Stichtenoth
Glutathione promotes prostaglandin H synthase (cyclooxygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2α.
FEBS letters 2012;586(20):3723-30.
2012: Henning Grosskopf; Anke Böhmer; Dimitrios Tsikas
Letter to the editor: "Role of the human erythrocyte in generation and storage of asymmetric dimethylarginine".
American journal of physiology. Heart and circulatory physiology 2012;303(6):H751-2.
2012: Darko Modun; Dimitrios Tsikas; Jonatan Vukovic; Visnja Kokic; Mladen Krnic; Lea Kukoc-Modun; Zeljko Dujic
Plasma nitrite concentration decreases after hyperoxia-induced oxidative stress in healthy humans.
Clinical physiology and functional imaging 2012;32(5):404-8.
2012: Dimitrios Tsikas; Maria-Theresia Suchy
Assessment of urinary F(2)-isoprostanes in experimental and clinical studies: mass spectrometry versus ELISA.
Hypertension 2012;60(2):e14; author reply e15.
2012: Kristine Chobanyan-Jürgens; Anibh M Das; Anne-Jule Fuchs; Sabine Illsinger; Jens Jordan; Nele Kanzelmeyer; Dimitrios Tsikas; Bernhard Vaske; Thomas Lücke
Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II.
Amino acids 2012;43(2):805-11.
2012: Dimitrios Tsikas; Jonas Niemann; Markus Flentje; Darko Modun
Antioxidants and endothelial dysfunction in young and elderly people: is flow-mediated dilation useful to assess acute effects?
Hypertension 2012;60(1):e5; author reply e6-7.
2012: Carina Jarzimski; Jens Jordan; Matthias Karst; Joachim K Krauss; Marcus May; Christin Rakers; Dirk Scheinichen; Maria-Theresia Suchy; Dimitrios Tsikas; Alexander A Zoerner; Stefan Engeli
Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol?
British journal of clinical pharmacology 2012;74(1):54-9.
2012: Anke Böhmer; Henning Großkopf; Jens Jordan; Dimitrios Tsikas
Human hemoglobin does not contain asymmetric dimethylarginine (ADMA).
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2012;27(1):72-4.
2012: Jasna Marinovic; Darko Modun; Ante Obad; Dimitrios Tsikas; Nada Bilopavlovic; Toni Breskovic; Grgo Gunjaca; Marko Ljubkovic; Zeljko Dujic
Effects of successive air and nitrox dives on human vascular function.
European journal of applied physiology 2012;112(6):2131-7.
2012: Dimitrios Tsikas; Anke Böhmer; Markus Flentje; Jonas Niemann; Dirk O Stichtenoth
Extra-platelet NO and NO(+)-containing drugs are potent inhibitors of platelet aggregation in humans by cGMP-dependent and cGMP-independent mechanisms.
Blood 2012;119(22):5337-9; author reply 5339.
2012: Mani Haschemi Nassab; Thomas Hillemacher; Jens Jordan; Anja Mitschke; Mathias Rhein; Maria-Theresia Suchy; Helge Frieling; Frank-Mathias Gutzki; Alexander A Zoerner; Dimitrios Tsikas
Stable-isotope dilution GC-MS method for ethanol in vapour ethanol and microdialysis systems based on carbonate-catalyzed extractive pentafluorobenzoylation.
The Analyst 2012;137(10):2480-5.
2012: Christian Wolf; Dimitrios Tsikas; Frank Weidemann; Stefan D Anker; Johann Bauersachs; Georg Ertl; Johan M Lorenzen; Sylvia Stein; Stefan Störk OR Stoerk; Thomas Thum
Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease.
International journal of cardiology 2012;156(3):289-94.
2012: Dimitrios Tsikas; Alexander A Zoerner; Stefan Engeli; Sven Haufe; Dirk O Stichtenoth; Jens Jordan
Microdialysis of prostaglandins, thromboxane, and other eicosanoids: recall past knowledge.
Hypertension 2012;59(5):e39; author reply e40.
2012: Nele Kanzelmeyer; Dimitrios Tsikas; Bernhard Vaske; Bibiana Beckmann; Kristine Chobanyan-Jürgens; Anibh M Das; Sabine Illsinger; Thomas Lücke
Asymmetric dimethylarginine in children with homocystinuria or phenylketonuria.
Amino acids 2012;42(5):1765-72.
2012: Dimitrios Tsikas; Jonas Niemann
Nitric oxide, peroxynitrite, S-nitrosothiols and thiols are unlikely to exert their effects on recombinant cyclooxygenase-1 and cyclooxygenase-2 activity in vitro by modifying cysteine moieties.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2012;26(3):192-4.
2012: Dimitrios Tsikas; Dirk O Stichtenoth
Dietary eicosapentaenoic acid (EPA) to produce antileukemic cyclopentenone prostaglandin J3?
Blood 2012;119(12):2967-8; author reply 2968.
2012: Dimitrios Tsikas; Dirk O Stichtenoth; Sven Haufe; Jens Jordan
Nitric oxide and hypertension.
Journal of hypertension 2012;30(3):625-6; author reply 626-7.
2012: Alexander A Zoerner; Sandor Batkai; Stefan Engeli; Jens Jordan; Marcus May; Christin Rakers; Dimitrios Tsikas
Peripheral endocannabinoid microdialysis: in vitro characterization and proof-of-concept in human subjects.
Analytical and bioanalytical chemistry 2012;402(9):2727-35.
2012: Kristine Chobanyan-Jürgens; Frank-Mathias Gutzki; Jan T Michaelsen; Alexandra Schwarz; Dirk O Stichtenoth; Bibiana Beckmann; Anke Böhmer; Dimitrios Tsikas
Renal carbonic anhydrases are involved in the reabsorption of endogenous nitrite.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2012;26(2):126-31.
2012: Anke Böhmer; Frank-Mathias Gutzki; Anja Mitschke; Anna Reib; Dimitrios Tsikas
¹⁸O-Labeled nitrous acid and nitrite: Synthesis, characterization, and oxyhemoglobin-catalyzed oxidation to ¹⁸O-labeled nitrate.
Analytical biochemistry 2012;421(2):770-2.
2012: Christin Rakers; Sandor Batkai; Stefan Engeli; Jens Jordan; Alexander A Zoerner; Dimitrios Tsikas
Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity.
Analytical biochemistry 2012;421(2):699-705.
2012: Anke Böhmer; Jörg Sandmann; Bibiana Beckmann; Dimitrios Tsikas
Doubts concerning functional endothelial nitric oxide synthase in human erythrocytes.
Blood 2012;119(5):1322-3.
2012: Dimitrios Tsikas; Anke Böhmer; Markus Flentje
Tetrahydrobiopterin and endothelial nitric oxide synthase uncoupling.
Hypertension 2012;59(2):e12.
2012: Alexander A Zoerner; Sandor Batkai; Stefan Engeli; Frank-Mathias Gutzki; Jens Jordan; Maria-Theresia Suchy; Dimitrios Tsikas
Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;883-884():161-71.
2012: Dimitrios Tsikas; Bibiana Beckmann; Anja Mitschke; Maria-Theresia Suchy; Frank-Mathias Gutzki
Measurement of nitrite in urine by gas chromatography-mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2012;844():277-93.
2012: Dimitrios Tsikas; Anja Mitschke; Frank-Mathias Gutzki
Measurement of 3-nitro-tyrosine in human plasma and urine by gas chromatography-tandem mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2012;828():255-70.
2011: Kristine Chobanyan-Jürgens; Vu Vi Pham; Dirk O Stichtenoth; Dimitrios Tsikas
Elevated dimethylarginine dimethylaminohydrolase (DDAH) activity in rheumatoid arthritis and spondyloarthritis.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011;25(4):436-8.
2011: Kristine Chobanyan-Jürgens; Vu Vi Pham; Dirk O Stichtenoth; Dimitrios Tsikas
Asymmetrical dimethylarginine, oxidative stress, and atherosclerosis.
Hypertension 2011;58(5):e184-5; author reply e186.
2011: Alexander A Zoerner; Sandor Batkai; Stefan Engeli; Frank-Mathias Gutzki; Jens Jordan; Marcus May; Christin Rakers; Dimitrios Tsikas
Quantification of endocannabinoids in biological systems by chromatography and mass spectrometry: a comprehensive review from an analytical and biological perspective.
Biochimica et biophysica acta 2011;1811(11):706-23.
2011: Dimitrios Tsikas; Alexander A Zoerner; Jens Jordan
Oxidized and nitrated oleic acid in biological systems: analysis by GC-MS/MS and LC-MS/MS, and biological significance.
Biochimica et biophysica acta 2011;1811(11):694-705.
2011: Daniela Giustarini; Dimitrios Tsikas; Ranieri Rossi
Study of the effect of thiols on the vasodilatory potency of S-nitrosothiols by using a modified aortic ring assay.
Toxicology and applied pharmacology 2011;256(2):95-102.
2011: Dimitrios Tsikas; Stefan Engeli; Dirk O Stichtenoth; Jens Tank; Jens Jordan
Comment on: Ott et al. Reduction in basal nitric oxide activity causes albuminuria. Diabetes 2011;60:572-576.
Diabetes 2011;60(8):e21; author reply e22.
2011: Arne Trettin; Alexander A Zoerner; Anke Böhmer; Frank-Mathias Gutzki; Jens Jordan; Dirk O Stichtenoth; Dimitrios Tsikas
Quantification of acetaminophen (paracetamol) in human plasma and urine by stable isotope-dilution GC-MS and GC-MS/MS as pentafluorobenzyl ether derivative.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(23):2274-80.
2011: Dimitrios Tsikas; Bibiana Beckmann; Frank-Mathias Gutzki; Jens Jordan
Simultaneous gas chromatography-tandem mass spectrometry quantification of symmetric and asymmetric dimethylarginine in human urine.
Analytical biochemistry 2011;413(1):60-2.
2011: Dimitrios Tsikas; Arne Trettin; Alexander A Zörner; Frank-Mathias Gutzki
In-source formation of N-acetyl-p-benzoquinone imine (NAPQI), the putatively toxic acetaminophen (paracetamol) metabolite, after derivatization with pentafluorobenzyl bromide and GC-ECNICI-MS analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(17-18):1476-84.
2011: Alexander A Zoerner; Karsten Heusser; Frank-Mathias Gutzki; Anja Mitschke; Jens Tank; Dirk O Stichtenoth; Jens Jordan; Dimitrios Tsikas
Unique pentafluorobenzylation and collision-induced dissociation for specific and accurate GC-MS/MS quantification of the catecholamine metabolite 3,4-dihydroxyphenylglycol (DHPG) in human urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(17-18):1444-56.
2011: Alexandra Schwarz; Darko Modun; Karsten Heusser; Jens Tank; Frank-Mathias Gutzki; Anja Mitschke; Jens Jordan; Dimitrios Tsikas
Stable-isotope dilution GC-MS approach for nitrite quantification in human whole blood, erythrocytes, and plasma using pentafluorobenzyl bromide derivatization: nitrite distribution in human blood.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(17-18):1485-95.
2011: Arash Haghikia; Ewa Missol-Kolka; Dimitrios Tsikas; Letizia Venturini; Stephanie Brundiers; Mirko Castoldi; Martina U Muckenthaler; Matthias Eder; Britta Stapel; Thomas Thum; Aiden Haghikia; Elisabeth Petrasch-Parwez; Helmut Drexler; Denise Hilfiker-Kleiner; Michaela Scherr
Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes.
European heart journal 2011;32(10):1287-97.
2011: Dimitrios Tsikas
Comments on the article "Nitrosylated human serum albumin (SNO-HSA) induces apoptosis in tumor cells (Nitric Oxide 22 (2010) 259-265)".
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011;24(3):123-4.
2011: Anke Böhmer; Jens Jordan; Dimitrios Tsikas
High-performance liquid chromatography ultraviolet assay for human erythrocytic catalase activity by measuring glutathione as o-phthalaldehyde derivative.
Analytical biochemistry 2011;410(2):296-303.
2011: Dimitrios Tsikas
GC-MS and HPLC methods for peroxynitrite (ONOO- and O15NOO-) analysis: a study on stability, decomposition to nitrite and nitrate, laboratory synthesis, and formation of peroxynitrite from S-nitrosoglutathione (GSNO) and KO2.
The Analyst 2011;136(5):979-87.
2011: Lotte M Schmidt; Maria G Belvisi; Konrad A Bode; Judith Bauer; Claudia Schmidt; Maria-Theresia Suchy; Dimitrios Tsikas; Jutta Scheuerer; Felix Lasitschka; Herman-Josef Gröne; Alexander H Dalpke
Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2095-105.
2011: Dimitrios Tsikas; Dirk O Stichtenoth; Jens Jordan
Inorganic nitrate for blood pressure lowering?
Hypertension 2011;57(2):e1-2; author reply e3.
2011: Dimitrios Tsikas; Jörg Sandmann; Bibiana Beckmann
Analysis of NO and its metabolites by mass spectrometry. Comment on 'Detection of nitric oxide in tissue samples by ESI-MS' by Z. Shen, A. Webster, K. J. Welham, C. E. Dyer, J. Greenman and S. J. Haswell.
The Analyst 2011;136(2):407-10; discussion 411.
2010: Edzard Schwedhelm; A Bierend; Renke Maas; R Trinks; Ghainsom D Kom; Dimitrios Tsikas; Rainer H Böger
Redox-generated isoprostanes are associated with residual platelet activity in aspirin-treated patients with stable coronary heart disease.
Journal of thrombosis and haemostasis : JTH 2010;8(12):2662-70.
2010: Dimitrios Tsikas; Alexander A Zoerner; Frank-Mathias Gutzki; Ranieri Rossi
On the mercapturic acid pathway of nitric oxide: is S-nitrosoglutathione present in the bile?
Hepatology (Baltimore, Md.) 2010;52(5):1858-9; author reply 1859-60.
2010: Petra Krause; Esther Wätzig; Hasan Acil; Sarah König; Kirsten Unthan-Fechner; Dimitrios Tsikas; Irmelin Probst
Role of carbon monoxide and nitric oxide in adult rat hepatocytes proliferating in vitro: Effects of CAS 1609.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2010;23(3):220-6.
2010: Dimitrios Tsikas; Kristine Chobanyan-Jürgens
Quantification of carbonate by gas chromatography-mass spectrometry.
Analytical chemistry 2010;82(19):7897-905.
2010: Dimitrios Tsikas; Alexander Wolf; Anja Mitschke; Frank-Mathias Gutzki; Wolfgang Will; Michael Bader
GC-MS determination of creatinine in human biological fluids as pentafluorobenzyl derivative in clinical studies and biomonitoring: Inter-laboratory comparison in urine with Jaffé, HPLC and enzymatic assays.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(27):2582-92.
2010: Dimitrios Tsikas
Identifying and quantifying contaminants contributing to endogenous analytes in gas chromatography/mass spectrometry.
Analytical chemistry 2010;82(18):7835-41.
2010: Ulrike Dreissigacker; Marcel Wendt; Torge Wittke; Dimitrios Tsikas; Norbert Maassen
Positive correlation between plasma nitrite and performance during high-intensive exercise but not oxidative stress in healthy men.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2010;23(2):128-35.
2010: Thomas Thum; Sandor Batkai; Philipp G Malinski; Thomas Becker; Iris Mevius; Jürgen Klempnauer; Hartmut H Meyer; Jürgen C Frölich; Jürgen Borlak; Dimitrios Tsikas
Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease.
Liver international : official journal of the International Association for the Study of the Liver 2010;30(8):1181-8.
2010: Dimitrios Tsikas; Anke Böhmer; Anja Mitschke
Gas chromatography-mass spectrometry analysis of nitrite in biological fluids without derivatization.
Analytical chemistry 2010;82(12):5384-90.
2010: Dimitrios Tsikas; Stefan Engeli; Bibiana Beckmann; Jens Jordan
Asymmetric dimethylarginine (ADMA) is present in plasma proteins of healthy subjects at the low nmol-per-g-level.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2010;22(4):316-7.
2010: Dimitrios Tsikas; Alexandra Schwarz; Dirk O Stichtenoth
Simultaneous measurement of [15N]nitrate and [15N]nitrite enrichment and concentration in urine by gas chromatography mass spectrometry as pentafluorobenzyl derivatives.
Analytical chemistry 2010;82(6):2585-7.
2010: Dimitrios Tsikas; Anja Mitschke; Frank-Mathias Gutzki; Stefan Engeli; Jens Jordan
Evidence by gas chromatography-mass spectrometry of ex vivo nitrite and nitrate formation from air nitrogen oxides in human plasma, serum, and urine samples.
Analytical biochemistry 2010;397(1):126-8.
2010: Dimitrios Tsikas
Quantitative analysis of biomarkers, drugs and toxins in biological samples by immunoaffinity chromatography coupled to mass spectrometry or tandem mass spectrometry: A focused review of recent applications.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(2):133-48.
2010: Dimitrios Tsikas
Measurement of nitrotyrosine in plasma by immunoassays is fraught with danger: commercial availability is no guarantee of analytical reliability.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2010;48(1):141-3; author reply 145-6.
2010: Ulrike Dreissigacker; Maria-Theresia Suchy; Norbert Maassen; Dimitrios Tsikas
Human plasma concentrations of malondialdehyde (MDA) and the F2-isoprostane 15(S)-8-iso-PGF(2alpha) may be markedly compromised by hemolysis: evidence by GC-MS/MS and potential analytical and biological ramifications.
Clinical biochemistry 2010;43(1-2):159-67.
2009: V Vi Pham; Dirk O Stichtenoth; Dimitrios Tsikas
Nitrite correlates with 3-nitrotyrosine but not with the F(2)-isoprostane 15(S)-8-iso-PGF(2alpha) in urine of rheumatic patients.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2009;21(3-4):210-5.
2009: Dimitrios Tsikas; Bibiana Beckmann
Albumin from human serum does not contain asymmetric dimethylarginine (ADMA).
Clinical biochemistry 2009;42(16-17):1739-40; author reply 1741.
2009: Jan Thomas Michaelsen; Sabine Dehnert; Daniela Giustarini; Bibiana Beckmann; Dimitrios Tsikas
HPLC analysis of human erythrocytic glutathione forms using OPA and N-acetyl-cysteine ethyl ester: evidence for nitrite-induced GSH oxidation to GSSG.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(28):3405-17.
2009: Dimitrios Tsikas; Sabine Dehnert; Karin Urban; Andrzej Surdacki; Hartmut H Meyer
GC-MS analysis of S-nitrosothiols after conversion to S-nitroso-N-acetyl cysteine ethyl ester and in-injector nitrosation of ethyl acetate.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(28):3442-55.
2009: Jens Martens-Lobenhoffer; Edzard Schwedhelm; Dimitrios Tsikas
Quantification of arginine and its mono- and dimethylated analogs NMMA, ADMA and SDMA in biological fluids by LC-MS/MS: Is LC superfluous?
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(27):3261-6.
2009: Alexander A Zoerner; Frank-Mathias Gutzki; Maria-Theresia Suchy; Bibiana Beckmann; Stefan Engeli; Jens Jordan; Dimitrios Tsikas
Targeted stable-isotope dilution GC-MS/MS analysis of the endocannabinoid anandamide and other fatty acid ethanol amides in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2909-23.
2009: Dimitrios Tsikas; Alexander Zoerner; Anja Mitschke; Yahya Homsi; Frank-Mathias Gutzki; Jens Jordan
Specific GC-MS/MS stable-isotope dilution methodology for free 9- and 10-nitro-oleic acid in human plasma challenges previous LC-MS/MS reports.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2895-908.
2009: Dimitrios Tsikas; Alexander A Zoerner; Anja Mitschke; Frank-Mathias Gutzki
Nitro-fatty acids occur in human plasma in the picomolar range: a targeted nitro-lipidomics GC-MS/MS study.
Lipids 2009;44(9):855-65.
2009: Joelle Magné; Jean-François Huneau; Dimitrios Tsikas; Stéphanie Delemasure; Luc Rochette; Daniel Tomé; François Mariotti
Rapeseed protein in a high-fat mixed meal alleviates postprandial systemic and vascular oxidative stress and prevents vascular endothelial dysfunction in healthy rats.
The Journal of nutrition 2009;139(9):1660-6.
2009: Dimitrios Tsikas
A proposal for comparing methods of quantitative analysis of endogenous compounds in biological systems by using the relative lower limit of quantification (rLLOQ).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(23):2244-51.
2009: Dimitrios Tsikas
De novo synthesis of trideuteromethyl esters of amino acids for use in GC-MS and GC-tandem MS exemplified for ADMA in human plasma and urine: standardization, validation, comparison and proof of evidence for their aptitude as internal standards.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(23):2308-20.
2009: Dimitrios Tsikas
Comments on "Determination of S-nitrosoglutathione and other nitrosothiols by p-hydroxymercurybenzoate derivatization and reverse phase chromatography coupled with chemical vapor generation atomic fluorescence detection" by Bramanti et al.
Talanta 2009;79(2):552-3; author reply 554-5.
2009: Dimitrios Tsikas; Jens M Hohlfeld
On the importance of the use of proper approaches for comparison of analytical methods for serum nitrate and for evaluation of reference concentrations.
Clinical biochemistry 2009;42(10-11):1200-1; author reply 1197-9.
2009: Birgit Krausse-Opatz; Ulrike Wittkop; Frank M Gutzki; Cornelia Schmidt; B Jürgens-Saathoff; Sabine Meier; Bibiana Beckmann; Osamu Takikawa; Michael A Morgan; Dimitrios Tsikas; Dirk O Stichtenoth; Annette D Wagner; Henning Zeidler; Lars Köhler
Free iron ions decrease indoleamine 2,3-dioxygenase expression and reduce IFNgamma-induced inhibition of Chlamydia trachomatis infection.
Microbial pathogenesis 2009;46(6):289-97.
2009: Dimitrios Tsikas; Ranieri Rossi
Letter by Tsikas and Rossi regarding article, "Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction".
Circulation 2009;119(19):e531; author reply e532.
2009: Ranieri Rossi; Dimitrios Tsikas
S-Nitrosothiols in blood: does photosensitivity explain a 4-order-of-magnitude concentration range?
Clinical chemistry 2009;55(5):1036-8; author reply 1038-40.
2009: Athanasia Warnecke; Piet Luessen; Jörg Sandmann; Milos Ikic; S Rossa; Frank-Mathias Gutzki; Dirk O Stichtenoth; Dimitrios Tsikas
Application of a stable-isotope dilution technique to study the pharmacokinetics of human 15N-labelled S-nitrosoalbumin in the rat: possible mechanistic and biological implications.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(13):1375-87.
2009: Michael Bader; Wolfgang Rosenberger; Frank-Mathias Gutzki; Dimitrios Tsikas
Quantification of N-(3-chloro-2-hydroxypropyl)valine in human haemoglobin as a biomarker of epichlorohydrin exposure by gas chromatography-tandem mass spectrometry with stable-isotope dilution.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(13):1402-15.
2009: Hilke Andresen; Ulrike Bingel; Thomas Streichert; Achim Schmoldt; Alexander Andreas Zoerner; Dimitrios Tsikas; Ingo Just
Severe glycerol intoxication after Menière's disease diagnostic--case report and overview of kinetic data.
Clinical toxicology (Philadelphia, Pa.) 2009;47(4):312-6.
2009: Jan T Kielstein; Gerrit Hesse; Matthias J Bahr; Dimitrios Tsikas; Christoph Terkamp; Jens Martens-Lobenhoffer; Michael P Manns; Hermann Haller; Bernard Panning; Stefanie M Bode-Böger; Michael Gebel
Procedure-related pulmonary hypertension in patients with hepatocellular carcinoma undergoing percutaneous ethanol injection--role of ethanol, hemolysis, asymmetric dimethylarginine, and the nitric oxide system.
Critical care medicine 2009;37(4):1483-5.
2009: Thomas Becker; Iris Mevius; Dorottya K de Vries; Alexander F M Schaapherder; Andreas Meyer zu Vilsendorf; Jürgen Klempnauer; Jürgen C Frölich; Dimitrios Tsikas
The L-arginine/NO pathway in end-stage liver disease and during orthotopic liver and kidney transplantation: biological and analytical ramifications.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2009;20(1):61-7.
2009: Daniela Giustarini; Isabella Dalle-Donne; Dimitrios Tsikas; Ranieri Rossi
Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers.
Critical reviews in clinical laboratory sciences 2009;46(5-6):241-81.
2008: Dimitrios Tsikas; Kristine Chobanyan
Pitfalls in the measurement of tissue DDAH activity: is DDAH sensitive to nitrosative and oxidative stress?
Kidney international 2008;74(7):969; author reply 969-70.
2008: Dimitrios Tsikas
Determination of asymmetric dimethylarginine in biological fluids: a paradigm for a successful analytical story.
Current opinion in clinical nutrition and metabolic care 2008;11(5):592-600.
2008: Daniela Fraccarollo; Julian Widder; Paolo Galuppo; Thomas Thum; Dimitrios Tsikas; Michael Hoffmann; Hartmut Ruetten; Georg Ertl; Johann Bauersachs
Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction.
Circulation 2008;118(8):818-27.
2008: Dimitrios Tsikas
A critical review and discussion of analytical methods in the L-arginine/nitric oxide area of basic and clinical research.
Analytical biochemistry 2008;379(2):139-63.
2008: Thomas Lücke; Nele Kanzelmeyer; Kristine Chobanyan; Dimitrios Tsikas; Doris Franke; Markus J Kemper; Jochen H H Ehrich; Anibh M Das
Elevated asymmetric dimethylarginine (ADMA) and inverse correlation between circulating ADMA and glomerular filtration rate in children with sporadic focal segmental glomerulosclerosis (FSGS).
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(2):734-40.
2008: Bibiana Beckmann; Frank-Mathias Gutzki; Dimitrios Tsikas
Sensitivity enhancement of a GC-MS/MS method for asymmetric dimethylarginine (ADMA) by plasma ultrafiltrate reduction.
Analytical biochemistry 2008;372(2):264-6.
2007: Thomas Thum; Felix Fleissner; Ivonne Klink; Dimitrios Tsikas; Marten Jakob; Johann Bauersachs; Dirk O Stichtenoth
Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I.
The Journal of clinical endocrinology and metabolism 2007;92(11):4172-9.
2007: Dimitrios Tsikas; Ranieri Rossi
Cocoa intake and blood pressure.
JAMA : the journal of the American Medical Association 2007;298(16):1862-3; author reply 1863-4.
2007: Kristine Chobanyan; Thomas Thum; Maria-Theresia Suchy; Bijun Zhu; Anja Mitschke; Frank-Mathias Gutzki; Bibiana Beckmann; Dirk O Stichtenoth; Dimitrios Tsikas
GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;858(1-2):32-41.
2007: Anousheh Kielstein; Dimitrios Tsikas; Gantt Galloway; John E Mendelson
Asymmetric dimethylarginine (ADMA)--a modulator of nociception in opiate tolerance and addiction?
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;17(2):55-9.
2007: Gesa K A Meyer; Anne Neetz; Gudrun Brandes; Dimitrios Tsikas; Joseph H Butterfield; Ingo Just; Ralf Gerhard
Clostridium difficile toxins A and B directly stimulate human mast cells.
Infection and immunity 2007;75(8):3868-76.
2007: Kristine Chobanyan; Anja Mitschke; Frank-Mathias Gutzki; Dirk O Stichtenoth; Dimitrios Tsikas
Accurate quantification of dimethylamine (DMA) in human plasma and serum by GC-MS and GC-tandem MS as pentafluorobenzamide derivative in the positive-ion chemical ionization mode.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;851(1-2):240-9.
2007: Anja Mitschke; Frank-Mathias Gutzki; Dimitrios Tsikas
9- and 10-Nitro-oleic acid do not interfere with the GC-MS quantitative determination of nitrite and nitrate in biological fluids when measured as their pentafluorobenzyl derivatives.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;851(1-2):287-91.
2007: Dimitrios Tsikas; Thomas Thum; Thomas Becker; Vu Vi Pham; Kristine Chobanyan; Anja Mitschke; Bibiana Beckmann; Frank-Mathias Gutzki; Johann Bauersachs; Dirk O Stichtenoth
Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;851(1-2):229-39.
2007: Dimitrios Tsikas
Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine/nitric oxide area of research.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;851(1-2):51-70.
2007: Thomas Thum; Daniela Fraccarollo; Maximilian Schultheiss; Sabrina Froese; Paolo Galuppo; Julian Widder; Dimitrios Tsikas; Georg Ertl; Johann Bauersachs
Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes.
Diabetes 2007;56(3):666-74.
2007: Thomas Thum; Sarah Hoeber; Sabrina Froese; Ivonne Klink; Dirk O Stichtenoth; Paolo Galuppo; Marten Jakob; Dimitrios Tsikas; Stefan D Anker; Philip A Poole-Wilson; Jürgen Borlak; Georg Ertl; Johann Bauersachs
Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.
Circulation research 2007;100(3):434-43.
2007: Thomas Lücke; Nele Kanzelmeyer; Markus J Kemper; Dimitrios Tsikas; Anibh M Das
Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(11):1525-30.
2006: Thomas Lücke; Dimitrios Tsikas; Nele Kanzelmeyer; Bernhard Vaske; Anibh M Das
Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in citrullinemia.
Metabolism: clinical and experimental 2006;55(12):1599-603.
2006: Christian Templin; Daniel Kotlarz; Frederik Marquart; Joerg Faulhaber; Vanessa Brendecke; Arnd Schaefer; Dimitrios Tsikas; Tomasz Bonda; Denise Hilfiker-Kleiner; Lars Ohl; Hassan Y Naim; Reinhold Foerster; Helmut Drexler; Florian P Limbourg
Transcoronary delivery of bone marrow cells to the infarcted murine myocardium: feasibility, cellular kinetics, and improvement in cardiac function.
Basic research in cardiology 2006;101(4):301-10.
2006: Thomas Thum; Daniela Fraccarollo; Paolo Galuppo; Dimitrios Tsikas; Stefan Frantz; Georg Ertl; Johann Bauersachs
Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells.
Cardiovascular research 2006;70(1):50-60.
2005: Dimitrios Tsikas; Anja Mitschke; Maria-Theresia Suchy; Frank-Mathias Gutzki; Dirk O Stichtenoth
Determination of 3-nitrotyrosine in human urine at the basal state by gas chromatography-tandem mass spectrometry and evaluation of the excretion after oral intake.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;827(1):146-56.
2005: Thomas Thum; Dimitrios Tsikas; Sylvia Stein; Maximilian Schultheiss; Martin Eigenthaler; Stefan D Anker; Philip A Poole-Wilson; Georg Ertl; Johann Bauersachs
Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.
Journal of the American College of Cardiology 2005;46(9):1693-701.
2005: Dirk O Stichtenoth; Verena Marhauer; Dimitrios Tsikas; Frank-Mathias Gutzki; Jürgen C Frölich
Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers.
Kidney international 2005;68(5):2197-207.
2005: Veit J Erpenbeck; Rudolf A Jörres; Marc Discher; Harald Krentel; Dimitrios Tsikas; Birgit Luettig; Norbert Krug; Jens Hohlfeld
Local nitric oxide levels reflect the degree of allergic airway inflammation after segmental allergen challenge in asthmatics.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2005;13(2):125-33.
2005: Dimitrios Tsikas
Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids.
Free radical research 2005;39(8):797-815.
2005: Jörg Sandmann; Kathrin S Schwedhelm; Dimitrios Tsikas
Specific transport of S-nitrosocysteine in human red blood cells: Implications for formation of S-nitrosothiols and transport of NO bioactivity within the vasculature.
FEBS letters 2005;579(19):4119-24.
2005: Danilo Fliser; Kathrin-Kristin Wagner; Astrid Loos; Dimitrios Tsikas; Hermann Haller
Chronic angiotensin II receptor blockade reduces (intra)renal vascular resistance in patients with type 2 diabetes.
Journal of the American Society of Nephrology : JASN 2005;16(4):1135-40.
2005: Dimitrios Tsikas; Edzard Schwedhelm; Jürgen C Frölich
Unusual collision-induced dissociation of fluorated and non-fluorated alpha-nitrotoluene analogs in a gas chromatograph triple-stage quadrupole mass spectrometer under electron-capturing negative-ion chemical ionization conditions.
Journal of chromatography. A 2005;1067(1-2):337-45.
2005: Dimitrios Tsikas; Kenneth Caidahl
Recent methodological advances in the mass spectrometric analysis of free and protein-associated 3-nitrotyrosine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;814(1):1-9.
2004: Dimitrios Tsikas
Assessment of nitric oxide biosynthesis and peroxynitrite formation within the central nervous system by measuring L-citrulline in the cerebrospinal fluid?
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;813(1-2):359-61.
2004: Dimitrios Tsikas; Juergen Dr.Froelich
Trouble with the analysis of nitrite, nitrate, S-nitrosothiols and 3-nitrotyrosine: freezing-induced artifacts?
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2004;11(3):209-13; author reply 214-5.
2004: Rainer H Böger; Dimitrios Tsikas; Stefanie M Bode-Böger; Laddaval Phivthong-Ngam; Edzard Schwedhelm; Jürgen C Frölich
Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-(15)N(2)]-arginine to (15)N-labeled nitrate by gas chromatography--mass spectrometry.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2004;11(1):1-8.
2004: Dimitrios Tsikas
Mass spectrometry-validated HPLC method for urinary nitrate.
Clinical chemistry 2004;50(7):1259-61.
2004: Dimitrios Tsikas
S-nitrosoalbumin and other S-nitrosothiols in the blood: is their quantity of no relevance?
Circulation research 2004;94(12):e106.
2004: Dimitrios Tsikas
Handling of commercially available enzyme immunoassays for 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha, iPF2alpha-III, 15-F2t-IsoP) in clinical research and science: considerations from the analytical and review point of view.
Clinica chimica acta; international journal of clinical chemistry 2004;344(1-2):215-7; author relpy 219-20.
2004: Dimitrios Tsikas; Anja Mitschke; Frank-Mathias Gutzki; Hartmut H Meyer; Jürgen C Frölich
Gas chromatography-mass spectrometry of cis-9,10-epoxyoctadecanoic acid (cis-EODA). II. Quantitative determination of cis-EODA in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;804(2):403-12.
2004: Karsten Sydow; Burkhard Hornig; Naoshi Arakawa; Stefanie M Bode-Böger; Dimitrios Tsikas; Thomas Münzel; Rainer H Böger
Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA.
Vascular medicine (London, England) 2004;9(2):93-101.
2004: Guido Eisele; Edzard Schwedhelm; Bernhard Schieffer; Dimitrios Tsikas; Rainer H Böger
Acetylsalicylic acid inhibits monocyte adhesion to endothelial cells by an antioxidative mechanism.
Journal of cardiovascular pharmacology 2004;43(4):514-21.
2004: Stefanie A Fahlbusch; Dimitrios Tsikas; Christina Mehls; Frank-Mathias Gutzki; Rainer H Böger; Jürgen C Frölich; Dirk O Stichtenoth
Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers.
European journal of clinical pharmacology 2004;60(2):83-8.
2004: Edzard Schwedhelm; Asja Bartling; Henrike Lenzen; Dimitrios Tsikas; Renke Maas; Jens Brümmer; Frank-Mathias Gutzki; Jürgen Berger; Jürgen C Frölich; Rainer H Böger
Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control study.
Circulation 2004;109(7):843-8.
2004: Jan T Kielstein; Burcu Impraim; Solveig Simmel; Stefanie M Bode-Böger; Dimitrios Tsikas; Juergen Dr.Froelich; Marius M Hoeper; Hermann Haller; Danilo Fliser
Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans.
Circulation 2004;109(2):172-7.
2004: Dimitrios Tsikas
Measurement of nitric oxide synthase activity in vivo and in vitro by gas chromatography-mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2004;279():81-103.
2004: Dimitrios Tsikas; Alexander Wolf; Jürgen C Frölich
Simplified HPLC method for urinary and circulating creatinine.
Clinical chemistry 2004;50(1):201-3.
2004: Dimitrios Tsikas; Juergen Dr.Froelich; Jan T Kielstein
Nitric oxide synthesis in chronic renal failure. Are plasma S-nitrosothiol levels elevated?
Clinica chimica acta; international journal of clinical chemistry 2004;339(1-2):195-7.
2003: Thomas Thum; Dimitrios Tsikas; Juergen Dr.Froelich; Jürgen Borlak
Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line.
FEBS letters 2003;555(3):567-71.
2003: Dimitrios Tsikas; Bibiana Schubert; Frank-Mathias Gutzki; Jörg Sandmann; Jürgen C Frölich
Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectrometry as methyl ester tri(N-pentafluoropropionyl) derivative.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;798(1):87-99.
2003: Dimitrios Tsikas; Iris Rode; Thomas Becker; Björn Nashan; Jürgen Klempnauer; Juergen Dr.Froelich
Elevated plasma and urine levels of ADMA and 15(S)-8-iso-PGF2alpha in end-stage liver disease.
Hepatology (Baltimore, Md.) 2003;38(4):1063-4.
2003: Dimitrios Tsikas; Jurgen C Frolich
Are plasma S-nitrosothiol levels elevated in chronic renal failure?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(10):2199; author reply: 2199-200.
2003: Dimitrios Tsikas; Edzard Schwedhelm; Maria-Theresia Suchy; Jonas Niemann; Frank-Mathias Gutzki; Veit J Erpenbeck; Jens Hohlfeld; Andrzej Surdacki; Jürgen C Frölich
Divergence in urinary 8-iso-PGF(2alpha) (iPF(2alpha)-III, 15-F(2t)-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF(2alpha). Possible methodological, mechanistic and clinical implications.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;794(2):237-55.
2003: Dimitrios Tsikas
Measurement of physiological S-nitrosothiols: a problem child and a challenge.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;9(1):53-5.
2003: Andrzej Surdacki; Dimitrios Tsikas; Ertan Mayatepek; Jürgen C Frölich
Elevated urinary excretion of nitric oxide metabolites in young infants with Zellweger syndrome.
Clinica chimica acta; international journal of clinical chemistry 2003;334(1-2):111-5.
2003: Makrina D Savvidou; Aroon D Hingorani; Dimitrios Tsikas; Juergen Dr.Froelich; Patrick Vallance; Kypros H Nicolaides
Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia.
Lancet 2003;361(9368):1511-7.
2003: Dimitrios Tsikas; Masayuki Sawa; Gorig Brunner; Frank-Mathias Gutzki; Hartmut H Meyer; Jürgen C Frölich
Gas chromatography-mass spectrometry of cis-9,10-epoxyoctadecanoic acid (cis-EODA). I. Direct evidence for cis-EODA formation from oleic acid oxidation by liver microsomes and isolated hepatocytes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;784(2):351-65.
2003: Stefan Machtens; Stefan Ckert; Christian G Stief; Dimitrios Tsikas; J rgen C Frlich; Udo Jonas
Effects of various nitric oxide-donating drugs on adrenergic tension of human seminal vesicles in vitro.
Urology 2003;61(2):479-83.
2003: Roland Keimer; Friederike K Stutzer; Dimitrios Tsikas; Raphael Troost; Frank-Mathias Gutzki; Jürgen C Frölich
Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study.
Journal of cardiovascular pharmacology 2003;41(2):284-92.
2003: Dimitrios Tsikas; Edzard Schwedhelm; Friedericke K Stutzer; Frank-Mathias Gutzki; Iris Rode; Christina Mehls; Jürgen C Frölich
Accurate quantification of basal plasma levels of 3-nitrotyrosine and 3-nitrotyrosinoalbumin by gas chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;784(1):77-90.
2003: Karsten Sydow; Edzard Schwedhelm; Naoshi Arakawa; Stefanie M Bode-Böger; Dimitrios Tsikas; Burkhard Hornig; Jürgen C Frölich; Rainer H Böger
ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.
Cardiovascular research 2003;57(1):244-52.
2002: Michael Seidler; Stefan Uckert; Eginhard Waldkirch; Christian G Stief; Matthias Oelke; Dimitrios Tsikas; Michael Sohn; Udo Jonas
In vitro effects of a novel class of nitric oxide (NO) donating compounds on isolated human erectile tissue.
European urology 2002;42(5):523-8.
2002: Dimitrios Tsikas; Juergen Dr.Froelich
Is circulating nitrite a directly acting vasodilator?
Clinical science (London, England : 1979) 2002;103(1):107-8; author reply 108-10.
2002: Dimitrios Tsikas; Jörg Sandmann; Jürgen C Frölich
Measurement of S-nitrosoalbumin by gas chromatography--mass spectrometry. III. Quantitative determination in human plasma after specific conversion of the S-nitroso group to nitrite by cysteine and Cu(2+) via intermediate formation of S-nitrosocysteine and nitric oxide.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;772(2):335-46.
2002: Olaf Heuer; Stefan Uckert; Stefan Machtens; Christian G Stief; Dimitrios Tsikas; Jürgen C Frölich; Udo Jonas
Effects of various nitric oxide donating agents on the contractility and cyclic nucleotide turnover of human seminal vesicles in vitro.
Urology 2002;59(6):958-62.
2002: Christine Krämer; Julia Sunkomat; Jana Witte; Maren Luchtefeld; Michael Walden; Boris Schmidt; Dimitrios Tsikas; Rainer H Böger; Wolf-Georg Forssmann; Helmut Drexler; Bernhard Schieffer
Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.
Circulation research 2002;90(7):770-6.
2002: Dimitrios Tsikas; Edzard Schwedhelm; Juergen Dr.Froelich
Methodological considerations on the detection of 3-nitrotyrosine in the cardiovascular system.
Circulation research 2002;90(6):E70.
2002: Dimitrios Tsikas; Juergen Dr.Froelich
S-nitrosoalbumin plasma levels in health and disease: facts or artifacts? Value of analytical chemistry in nitric oxide clinical research.
Circulation research 2002;90(3):e39.
2001: Dirk O Stichtenoth; F J Kreutzer; Frank-Mathias Gutzki; Dimitrios Tsikas; V Nowak; Jürgen C Frölich
Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial disease.
Prostaglandins, leukotrienes, and essential fatty acids 2001;65(4):211-4.
2001: Dimitrios Tsikas; K Denker; Jürgen C Frölich
Artifactual-free analysis of S-nitrosoglutathione and S-nitroglutathione by neutral-pH, anion-pairing, high-performance liquid chromatography. Study on peroxynitrite-mediated S-nitration of glutathione to S-nitroglutathione under physiological conditions.
Journal of chromatography. A 2001;915(1-2):107-16.
2001: Dimitrios Tsikas; Jörg Sandmann; P Luessen; A Savva; S Rossa; Dirk O Stichtenoth; Jürgen C Frölich
S-Transnitrosylation of albumin in human plasma and blood in vitro and in vivo in the rat.
Biochimica et biophysica acta 2001;1546(2):422-34.
2000: Armin J Becker; Stefan Uckert; Dimitrios Tsikas; H Noack; Christian G Stief; Jürgen C Frölich; Gerald Wolf; Udo Jonas
Determination of nitric oxide metabolites by means of the Griess assay and gas chromatography-mass spectrometry in the cavernous and systemic blood of healthy males and patients with erectile dysfunction during different functional conditions of the penis.
Urological research 2000;28(6):364-9.
2000: Raphael Troost; Edzard Schwedhelm; S Rojczyk; Dimitrios Tsikas; Jürgen C Frölich
Nebivolol decreases systemic oxidative stress in healthy volunteers.
British journal of clinical pharmacology 2000;50(4):377-9.
2000: Dimitrios Tsikas
Simultaneous derivatization and quantification of the nitric oxide metabolites nitrite and nitrate in biological fluids by gas chromatography/mass spectrometry.
Analytical chemistry 2000;72(17):4064-72.
2000: Dimitrios Tsikas; Rainer H Böger; Jörg Sandmann; Stefanie M Bode-Böger; Jürgen C Frölich
Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox.
FEBS letters 2000;478(1-2):1-3.
2000: Rainer H Böger; Karsten Sydow; Jürgen Borlak; Thomas Thum; Henrike Lenzen; B Schubert; Dimitrios Tsikas; Stefanie M Bode-Böger
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.
Circulation research 2000;87(2):99-105.
2000: Dimitrios Tsikas; Frank-Mathias Gutzki; M Böhme; I Fuchs; Jürgen C Frölich
Solid- and liquid-phase extraction for the gas chromatographic-tandem mass spectrometric quantification of 2,3-dinor-thromboxane B2 and 2,3-dinor-6-oxo-prostaglandin F1 alpha in human urine.
Journal of chromatography. A 2000;885(1-2):351-9.
2000: Edzard Schwedhelm; Dimitrios Tsikas; Thierry Durand; Frank-Mathias Gutzki; Alexandre Guy; Jean-Claude Rossi; Jürgen C Frölich
Tandem mass spectrometric quantification of 8-iso-prostaglandin F2alpha and its metabolite 2,3-dinor-5,6-dihydro-8-iso-prostaglandin F2alpha in human urine.
Journal of chromatography. B, Biomedical sciences and applications 2000;744(1):99-112.
2000: Dimitrios Tsikas; Jörg Sandmann; A Savva; P Luessen; Rainer H Böger; Frank-Mathias Gutzki; B Mayer; Jürgen C Frölich
Assessment of nitric oxide synthase activity in vitro and in vivo by gas chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2000;742(1):143-53.
2000: Dimitrios Tsikas; Manfred Raida; Jörg Sandmann; S Rossa; Wolf-Georg Forssmann; Jürgen C Frölich
Electrospray ionization mass spectrometry of low-molecular-mass S-nitroso compounds and their thiols.
Journal of chromatography. B, Biomedical sciences and applications 2000;742(1):99-108.
1999: Edzard Schwedhelm; Dimitrios Tsikas; Frank-Mathias Gutzki; Jürgen C Frölich
Gas chromatographic-tandem mass spectrometric quantification of free 3-nitrotyrosine in human plasma at the basal state.
Analytical biochemistry 1999;276(2):195-203.
1999: Dimitrios Tsikas; Frank-Mathias Gutzki; Jörg Sandmann; Edzard Schwedhelm; Jürgen C Frölich
Gas chromatographic-tandem mass spectrometric quantification of human plasma and urinary nitrate after its reduction to nitrite and derivatization to the pentafluorobenzyl derivative.
Journal of chromatography. B, Biomedical sciences and applications 1999;731(2):285-91.
1999: Dimitrios Tsikas; Jörg Sandmann; D Holzberg; P Pantazis; Manfred Raida; Jürgen C Frölich
Determination of S-nitrosoglutathione in human and rat plasma by high-performance liquid chromatography with fluorescence and ultraviolet absorbance detection after precolumn derivatization with o-phthalaldehyde.
Analytical biochemistry 1999;273(1):32-40.
1999: Dimitrios Tsikas; Jörg Sandmann; S Rossa; Frank-Mathias Gutzki; Jürgen C Frölich
Gas chromatographic-mass spectrometric detection of S-nitroso-cysteine and S-nitroso-glutathione.
Analytical biochemistry 1999;272(2):117-22.
1999: Andrzej Surdacki; M Nowicki; J Sandmann; Dimitrios Tsikas; O Kruszelnicka-Kwiatkowska; F Kokot; Jacek S Dubiel; J C Froelich
Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls.
Metabolism: clinical and experimental 1999;48(7):887-91.
1999: Dimitrios Tsikas; Jörg Sandmann; Frank-Mathias Gutzki; Jürgen C Frölich
Interference by S-nitroso compounds with the measurement of nitrate in methods requiring reduction of nitrate to nitrite by cadmium.
Journal of chromatography. B, Biomedical sciences and applications 1999;729(1-2):375-8.
1999: Dimitrios Tsikas; Jörg Sandmann; S Rossa; Frank-Mathias Gutzki; Jürgen C Frölich
Investigations of S-transnitrosylation reactions between low- and high-molecular-weight S-nitroso compounds and their thiols by high-performance liquid chromatography and gas chromatography-mass spectrometry.
Analytical biochemistry 1999;270(2):231-41.
1999: Dimitrios Tsikas; Jörg Sandmann; Frank-Mathias Gutzki; Dirk O Stichtenoth; Jürgen C Frölich
Measurement of S-nitrosoalbumin by gas chromatography-mass spectrometry. II. Quantitative determination of S-nitrosoalbumin in human plasma using S-[15N]nitrosoalbumin as internal standard.
Journal of chromatography. B, Biomedical sciences and applications 1999;726(1-2):13-24.
1999: Dimitrios Tsikas; Jörg Sandmann; S Rossa; Frank-Mathias Gutzki; Jürgen C Frölich
Measurement of S-nitrosoalbumin by gas chromatography-mass spectrometry. I. Preparation, purification, isolation, characterization and metabolism of S-[15N]nitrosoalbumin in human blood in vitro.
Journal of chromatography. B, Biomedical sciences and applications 1999;726(1-2):1-12.
1999: Andrzej Surdacki; M Nowicki; J Sandmann; Dimitrios Tsikas; R H Boeger; S M Bode-Boeger; O Kruszelnicka-Kwiatkowska; F Kokot; Jacek S Dubiel; J C Froelich
Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension.
Journal of cardiovascular pharmacology 1999;33(4):652-8.
1999: Dimitrios Tsikas; S Rossa; Jörg Sandmann; Jürgen C Frölich
High-performance liquid chromatographic analysis of nitrite and nitrate in human plasma as S-nitroso-N-acetylcysteine with ultraviolet absorbance detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;724(1):199-201.
1999: Dimitrios Tsikas; M Ikic; KS Tewes; Manfred Raida; Jürgen C Frölich
Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets.
FEBS letters 1999;442(2-3):162-6.
1998: Rainer H Böger; Stefanie M Bode-Böger; Laddaval Phivthong-Ngam; RP Brandes; Edzard Schwedhelm; A Mügge; M Böhme; Dimitrios Tsikas; Jürgen C Frölich
Dietary L-arginine and alpha-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms.
Atherosclerosis 1998;141(1):31-43.
1998: Stefanie M Bode-Böger; Rainer H Böger; A Galland; Dimitrios Tsikas; Jürgen C Frölich
L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship.
British journal of clinical pharmacology 1998;46(5):489-97.
1998: Dimitrios Tsikas
Application of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry to assess in vivo synthesis of prostaglandins, thromboxane, leukotrienes, isoprostanes and related compounds in humans.
Journal of chromatography. B, Biomedical sciences and applications 1998;717(1-2):201-45.
1998: Dimitrios Tsikas; Edzard Schwedhelm; J Fauler; Frank-Mathias Gutzki; Ertan Mayatepek; Jürgen C Frölich
Specific and rapid quantification of 8-iso-prostaglandin F2alpha in urine of healthy humans and patients with Zellweger syndrome by gas chromatography-tandem mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 1998;716(1-2):7-17.
1998: Dimitrios Tsikas; I Fuchs; Frank-Mathias Gutzki; Jürgen C Frölich
Measurement of nitrite and nitrate in plasma, serum and urine of humans by high-performance liquid chromatography, the Griess assay, chemiluminescence and gas chromatography-mass spectrometry: interferences by biogenic amines and N(G)-nitro-L-arginine analogs.
Journal of chromatography. B, Biomedical sciences and applications 1998;715(2):441-4; discussion 445-8.
1998: Dimitrios Tsikas; Edzard Schwedhelm; Frank-Mathias Gutzki; Jürgen C Frölich
Gas chromatographic-mass spectrometric discrimination between 8-iso-prostaglandin E2 and prostaglandin E2 through derivatization by O-(2,3,4,5,6-Pentafluorobenzyl)hydroxyl amine.
Analytical biochemistry 1998;261(2):230-2.
1998: KS Tewes; Dimitrios Tsikas; Frank-Mathias Gutzki; J C Frolich
Measurement of thromboxane B2 in platelet-rich human plasma by gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry following extractive pentafluorobenzyl esterification.
Analytical biochemistry 1998;261(1):121-4.
1998: Dimitrios Tsikas; KS Tewes; Frank-Mathias Gutzki; Edzard Schwedhelm; J Greipel; Jürgen C Frölich
Gas chromatographic-tandem mass spectrometric determination of acetylsalicylic acid in human plasma after oral administration of low-dose aspirin and guaimesal.
Journal of chromatography. B, Biomedical sciences and applications 1998;709(1):79-88.
1998: Dimitrios Tsikas; Jörg Sandmann; M Ikic; J Fauler; Dirk O Stichtenoth; Jürgen C Frölich
Analysis of cysteine and N-acetylcysteine in human plasma by high-performance liquid chromatography at the basal state and after oral administration of N-acetylcysteine.
Journal of chromatography. B, Biomedical sciences and applications 1998;708(1-2):55-60.
1998: Stefanie M Bode-Böger; Rainer H Böger; S Kienke; M Böhme; Laddaval Phivthong-Ngam; Dimitrios Tsikas; Jürgen C Frölich
Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo.
Cardiovascular research 1998;37(3):756-64.
1997: Dimitrios Tsikas; Frank-Mathias Gutzki; S Rossa; H Bauer; C Neumann; K Dockendorff; Jörg Sandmann; Jürgen C Frölich
Measurement of nitrite and nitrate in biological fluids by gas chromatography-mass spectrometry and by the Griess assay: problems with the Griess assay--solutions by gas chromatography-mass spectrometry.
Analytical biochemistry 1997;244(2):208-20.
1996: Rainer H Böger; Stefanie M Bode-Böger; P Kramme; Dimitrios Tsikas; Frank-Mathias Gutzki; Jürgen C Frölich
Effect of captopril on prostacyclin and nitric oxide formation in healthy human subjects: interaction with low dose acetylsalicylic acid.
British journal of clinical pharmacology 1996;42(6):721-7.
1996: Dimitrios Tsikas; J Fauler; R D Velásquez; Frank-Mathias Gutzki; Jürgen C Frölich
Catalytic hydrogenation of leukotriene B4 enhances sensitivity and specificity of gas chromatography-tandem mass spectrometry techniques and enables simultaneous analysis with cysteinyl leukotrienes in biological fluids.
Analytical biochemistry 1996;236(1):175-8.
1996: Dimitrios Tsikas; S Rossa; Dirk O Stichtenoth; Manfred Raida; Frank-Mathias Gutzki; Jürgen C Frölich
Is S-nitroso-N-acetyl-L-cysteine a circulating or an excretory metabolite of nitric oxide (NO) in man? Assessment by gas chromatography-mass spectrometry.
Biochemical and biophysical research communications 1996;220(3):939-44.
1996: R D Velásquez; G Brunner; M Varrentrapp; Dimitrios Tsikas; Jürgen C Frölich
Helicobacter pylori produces histamine and spermidine.
Zeitschrift für Gastroenterologie 1996;34(2):116-22.
1996: Dirk O Stichtenoth; Dimitrios Tsikas; Frank-Mathias Gutzki; Jürgen C Frölich
Effects of ketoprofen and ibuprofen on platelet aggregation and prostanoid formation in man.
European journal of clinical pharmacology 1996;51(3-4):231-4.
1996: R H Boger; S M Bode-Boger; U Gerecke; Frank-Mathias Gutzki; Dimitrios Tsikas; J C Frolich
Urinary NO3- excretion as an indicator of nitric oxide formation in vivo during oral administration of L-arginine or L-name in rats.
Clinical and experimental pharmacology & physiology 1996;23(1):11-5.
1996: Stefanie M Bode-Böger; Rainer H Böger; Heiko Alfke; D Heinzel; Dimitrios Tsikas; A Creutzig; K Alexander; Jürgen C Frölich
L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study.
Circulation 1996;93(1):85-90.
1995: Dirk O Stichtenoth; N Selve; Dimitrios Tsikas; Frank-Mathias Gutzki; Jürgen C Frölich
Increased total body synthesis of prostacyclin in rats with adjuvant arthritis.
Prostaglandins 1995;50(5-6):331-40.
1995: Dimitrios Tsikas; J Fauler; Jürgen C Frölich
Chemical synthesis of dioxygen-18 labelled omega-/beta-oxidized cysteinyl leukotrienes: analysis by gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry.
Journal of chromatography. B, Biomedical applications 1995;667(2):209-21.
1995: Rainer H Böger; Stefanie M Bode-Böger; E P Schröder; Dimitrios Tsikas; Jürgen C Frölich
Increased prostacyclin production during exercise in untrained and trained men: effect of low-dose aspirin.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(5):1832-8.
1994: Dimitrios Tsikas; Rainer H Böger; Stefanie M Bode-Böger; Frank-Mathias Gutzki; Jürgen C Frölich
Quantification of nitrite and nitrate in human urine and plasma as pentafluorobenzyl derivatives by gas chromatography-mass spectrometry using their 15N-labelled analogs.
Journal of chromatography. B, Biomedical applications 1994;661(2):185-91.
1994: J Fauler; Dimitrios Tsikas; Ertan Mayatepek; D Keppler; Jürgen C Frölich
Impaired degradation of prostaglandins and thromboxane in Zellweger syndrome.
Pediatric research 1994;36(4):449-55.
1994: Stefanie M Bode-Böger; Rainer H Böger; A Creutzig; Dimitrios Tsikas; Frank-Mathias Gutzki; K Alexander; Jürgen C Frölich
L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects.
Clinical science (London, England : 1979) 1994;87(3):303-10.
1994: Dirk O Stichtenoth; Frank-Mathias Gutzki; Dimitrios Tsikas; N Selve; Stefanie M Bode-Böger; Rainer H Böger; Jürgen C Frölich
Increased urinary nitrate excretion in rats with adjuvant arthritis.
Annals of the rheumatic diseases 1994;53(8):547-9.
1994: Jürgen C Frölich; J Fauler; Dimitrios Tsikas
Assessment of cysteinyl leukotriene synthesis in man.
Journal of lipid mediators and cell signalling 1994;9(1):75-8.
1994: J Fauler; Angelika Thon; Dimitrios Tsikas; H von der Hardt; Jürgen C Frölich
Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis.
Arthritis and rheumatism 1994;37(1):93-7.
1993: Dimitrios Tsikas; J Fauler; Frank-Mathias Gutzki; T Röder; HJ Bestmann; Jürgen C Frölich
Gas chromatographic-mass spectrometric determination of leukotriene E4 in human urine using deuterium-labelled leukotriene E4 standards.
Journal of chromatography 1993;622(1):1-7.
1993: Dimitrios Tsikas; J Fauler; S Bracht; G Brunner; Jürgen C Frölich
Analysis of leukotrienes, prostaglandins, thromboxane B2 and their metabolites by capillary isotachophoresis.
Electrophoresis 1993;14(7):664-6.
1993: J Fauler; C Neumann; Dimitrios Tsikas; J Frölich
Enhanced synthesis of cysteinyl leukotrienes in atopic dermatitis.
The British journal of dermatology 1993;128(6):627-30.
1993: Rainer H Böger; Stefanie M Bode-Böger; Frank-Mathias Gutzki; Dimitrios Tsikas; H P Weskott; Jürgen C Frölich
Rapid and selective inhibition of platelet aggregation and thromboxane formation by intravenous low dose aspirin in man.
Clinical science (London, England : 1979) 1993;84(5):517-24.
1993: Dimitrios Tsikas; R Velásquez; C Toledano; G Brunner
Ion-pair extraction of histamine from biological fluids and tissues for its determination by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography 1993;614(1):37-41.
1993: Ertan Mayatepek; W D Lehmann; J Fauler; Dimitrios Tsikas; J C Frölich; R B Schutgens; R J Wanders; Dietrich Keppler
Impaired degradation of leukotrienes in patients with peroxisome deficiency disorders.
The Journal of clinical investigation 1993;91(3):881-8.
1992: J H Wilkens; A Becker; H Wilkens; M Emura; M Riebe-Imre; K Plein; S Schöber; Dimitrios Tsikas; Frank-Mathias Gutzki; Jürgen C Frölich
Bioassay of a tracheal smooth muscle-constricting factor released by respiratory epithelial cells.
The American journal of physiology 1992;263(1 Pt 1):L137-41.
1992: J Fauler; C Neumann; Dimitrios Tsikas; Jürgen C Frölich
Enhanced synthesis of cysteinyl leukotrienes in psoriasis.
The Journal of investigative dermatology 1992;99(1):8-11.
1992: Dimitrios Tsikas; J Fauler; Jürgen C Frölich
Enzymic preparation of dioxygen-18 labelled leukotriene E4 and its use in quantitative gas chromatography-mass spectrometry.
Journal of chromatography 1992;574(2):181-7.
1992: Frank-Mathias Gutzki; Dimitrios Tsikas; U Alheid; Jürgen C Frölich
Determination of endothelium-derived nitrite/nitrate by gas chromatography/tandem mass spectrometry using (15N)NaNO2 as internal standard.
Biological mass spectrometry 1992;21(2):97-102.
1992: Dimitrios Tsikas; J Fauler; Jürgen C Frölich
Analysis of cysteinyl leukotrienes and leukotriene B4 by gas chromatography-(tandem) mass spectrometry.
Eicosanoids 1992;5 Suppl():S7-9.
1991: Dimitrios Tsikas; J Fauler; G Brunner; Jürgen C Frölich
Capillary isotachophoretic determination of cysteinyl leukotrienes.
Journal of chromatography 1991;545(2):375-8.
1991: J Fauler; Dimitrios Tsikas; Michael Holch; Andreas Seekamp; Michael Nerlich; J Sturm; Jürgen C Frölich
Enhanced urinary excretion of leukotriene E4 by patients with multiple trauma with or without adult respiratory distress syndrome.
Clinical science (London, England : 1979) 1991;80(5):497-504.
1989: Dimitrios Tsikas; G Brunner
Application of capillary isotachophoresis to the analysis of glutathione conjugates.
Journal of chromatography 1989;470(1):191-9.