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Hideo Tsukada

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Norihiro Harada; Takeharu Kakiuchi; Hiroyuki Ohba; Hideo Tsukada
Application of feedback-controlled bolus plus infusion (FC-B/I) method for quantitative PET imaging of dopamine transporters with [(18)F]β-CFT-FE in conscious monkey brain.
Hiroyuki Ohba; Norihiro Harada; Takeharu Kakiuchi; Yuichi Kimura; Shingo Nishiyama; Hideo Tsukada
Feedback-controlled bolus plus infusion (FC-B/I) method for quantitative drug assessment in living brain with PET.
Dai Fukumoto; Norihiro Harada; Shingo Nishiyama; Shigeyuki Yamamoto; Hideo Tsukada
Detection of ischemic neuronal damage with [¹⁸F]BMS-747158-02, a mitochondrial complex-1 positron emission tomography ligand: small animal PET study in rat brain.

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All Publications

2013: Norihiro Harada; Takeharu Kakiuchi; Hiroyuki Ohba; Hideo Tsukada
Application of feedback-controlled bolus plus infusion (FC-B/I) method for quantitative PET imaging of dopamine transporters with [(18)F]β-CFT-FE in conscious monkey brain.
Synapse (New York, N.Y.) 2013;67(1):42-50.
2013: Hiroyuki Ohba; Norihiro Harada; Takeharu Kakiuchi; Yuichi Kimura; Shingo Nishiyama; Hideo Tsukada
Feedback-controlled bolus plus infusion (FC-B/I) method for quantitative drug assessment in living brain with PET.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2013;33(1):85-90.
2012: Dai Fukumoto; Norihiro Harada; Shingo Nishiyama; Shigeyuki Yamamoto; Hideo Tsukada
Detection of ischemic neuronal damage with [¹⁸F]BMS-747158-02, a mitochondrial complex-1 positron emission tomography ligand: small animal PET study in rat brain.
Synapse (New York, N.Y.) 2012;66(10):909-17.
2011: Hideo Tsukada
[Application of pre-clinical PET imaging for drug development].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2011;31(5-6):231-7.
2011: Dai Fukumoto; Teruyo Hosoya; Shingo Nishiyama; Norihiro Harada; Hiroshi Iwata; Shigeyuki Yamamoto; Hideo Tsukada
Multiparametric assessment of acute and subacute ischemic neuronal damage: a small animal positron emission tomography study with rat photochemically induced thrombosis model.
Synapse (New York, N.Y.) 2011;65(3):207-14.
2011: Hideo Tsukada; Hiroyuki Ohba; Shingo Nishiyama; Takeharu Kakiuchi
Differential effects of stress on [¹¹C]raclopride and [¹¹C]MNPA binding to striatal D₂/D₃ dopamine receptors: a PET study in conscious monkeys.
Synapse (New York, N.Y.) 2011;65(1):84-9.
2009: Hiroyuki Ohba; Norihiro Harada; Shingo Nishiyama; Takeharu Kakiuchi; Hideo Tsukada
Ketamine/xylazine anesthesia alters [11C]MNPA binding to dopamine D2 receptors and response to methamphetamine challenge in monkey brain.
Synapse (New York, N.Y.) 2009;63(6):534-7.
2009: Edward Domino; Hideo Tsukada
Nicotine sensitization of monkey striatal dopamine release.
European journal of pharmacology 2009;607(1-3):91-5.
2005: Hideo Tsukada; Katsumasa Miyasato; Shingo Nishiyama; Dai Fukumoto; Takeharu Kakiuchi; Edward Domino
Nicotine normalizes increased prefrontal cortical dopamine D1 receptor binding and decreased working memory performance produced by repeated pretreatment with MK-801: a PET study in conscious monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(12):2144-53.
2005: Hideo Tsukada; Shingo Nishiyama; Dai Fukumoto; Kengo Sato; Takeharu Kakiuchi; Edward Domino
Chronic NMDA antagonism impairs working memory, decreases extracellular dopamine, and increases D1 receptor binding in prefrontal cortex of conscious monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(10):1861-9.
2005: Hideo Tsukada; Katsumasa Miyasato; Norihiro Harada; Shingo Nishiyama; Dai Fukumoto; Takeharu Kakiuchi
Nicotine modulates dopamine synthesis rate as determined by L-[beta-11C]DOPA: PET studies compared with [11C]raclopride binding in the conscious monkey brain.
Synapse (New York, N.Y.) 2005;57(2):120-2.
2005: Hideo Tsukada; Norihiro Harada; Shingo Nishiyama; Dai Fukumoto; Takeharu Kakiuchi
Acute NMDA receptor antagonism induces biphasic striatal utilization of L-[beta-11C]DOPA: PET studies in the conscious monkey brain.
Synapse (New York, N.Y.) 2005;57(2):116-9.
2004: Norihiro Harada; Hiroyuki Ohba; Dai Fukumoto; Takeharu Kakiuchi; Hideo Tsukada
Potential of [(18)F]beta-CFT-FE (2beta-carbomethoxy-3beta-(4-fluorophenyl)-8-(2-[(18)F]fluoroethyl)nortropane) as a dopamine transporter ligand: A PET study in the conscious monkey brain.
Synapse (New York, N.Y.) 2004;54(1):37-45.
2004: Hideo Tsukada
[Pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: PET study in conscious monkeys].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2004;124(3):153-61.
2004: Hideo Tsukada; Dai Fukumoto; Shingo Nishiyama; Kengo Sato; Takeharu Kakiuchi
Transient focal ischemia affects the cAMP second messenger system and coupled dopamine D1 and 5-HT1A receptors in the living monkey brain: a positron emission tomography study using microdialysis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004;24(8):898-906.
2004: Hideo Tsukada; Shingo Nishiyama; Dai Fukumoto; Hiroyuki Ohba; Kengo Sato; Takeharu Kakiuchi
Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis.
Synapse (New York, N.Y.) 2004;52(1):1-10.
2002: Hideo Tsukada; Katsumasa Miyasato; Takeharu Kakiuchi; Shingo Nishiyama; Norihiro Harada; Edward Domino
Comparative effects of methamphetamine and nicotine on the striatal [(11)C]raclopride binding in unanesthetized monkeys.
Synapse (New York, N.Y.) 2002;45(4):207-12.
2002: Norihiro Harada; Shingo Nishiyama; Kengo Satoh; Dai Fukumoto; Takeharu Kakiuchi; Hideo Tsukada
Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys.
Synapse (New York, N.Y.) 2002;45(1):38-45.
2002: Norihiro Harada; Shingo Nishiyama; Hiroyuki Ohba; Kengo Sato; Takeharu Kakiuchi; Hideo Tsukada
Age differences in phosphodiesterase type-IV and its functional response to dopamine D1 receptor modulation in the living brain: a PET study in conscious monkeys.
Synapse (New York, N.Y.) 2002;44(3):139-45.
2001: Hideo Tsukada; Shingo Nishiyama; Takeharu Kakiuchi; Hiroyuki Ohba; Kengo Sato; Norihiro Harada
Ketamine alters the availability of striatal dopamine transporter as measured by [(11)C]beta-CFT and [(11)C]beta-CIT-FE in the monkey brain.
Synapse (New York, N.Y.) 2001;42(4):273-80.
2001: Hideo Tsukada; Norihiro Harada; Hiroyuki Ohba; Shingo Nishiyama; Takeharu Kakiuchi
Facilitation of dopaminergic neural transmission does not affect [(11)C]SCH23390 binding to the striatal D(1) dopamine receptors, but the facilitation enhances phosphodiesterase type-IV activity through D(1) receptors: PET studies in the conscious monkey brain.
Synapse (New York, N.Y.) 2001;42(4):258-65.
2001: Hideo Tsukada; Takeharu Kakiuchi; Shingo Nishiyama; Hiroyuki Ohba; Norihiro Harada
Effects of aging on 5-HT(1A) receptors and their functional response to 5-HT(1a) agonist in the living brain: PET study with [carbonyl-(11)C]WAY-100635 in conscious monkeys.
Synapse (New York, N.Y.) 2001;42(4):242-51.
2001: Hideo Tsukada; Shingo Nishiyama; Hiroyuki Ohba; Kengo Sato; Norihiro Harada; Takeharu Kakiuchi
Cholinergic neuronal modulations affect striatal dopamine transporter activity: PET studies in the conscious monkey brain.
Synapse (New York, N.Y.) 2001;42(3):193-5.
2001: Takeharu Kakiuchi; Hiroyuki Ohba; Shingo Nishiyama; Kengo Sato; Norihiro Harada; S Nakanishi; Hideo Tsukada
Age-related changes in muscarinic cholinergic receptors in the living brain: a PET study using N-[11C]methyl-4-piperidyl benzilate combined with cerebral blood flow measurement in conscious monkeys.
Brain research 2001;916(1-2):22-31.
2001: Hideo Tsukada; Takeharu Kakiuchi; Shingo Nishiyama; Hiroyuki Ohba; Kengo Sato; Norihiro Harada; K Takahashi
Age differences in muscarinic cholinergic receptors assayed with (+)N-[(11)C]methyl-3-piperidyl benzilate in the brains of conscious monkeys.
Synapse (New York, N.Y.) 2001;41(3):248-57.
2001: Takeharu Kakiuchi; Hideo Tsukada; Dai Fukumoto; Shingo Nishiyama
Effects of aging on serotonin transporter availability and its response to fluvoxamine in the living brain: PET study with [(11)C](+)McN5652 and [(11)C](-)McN5652 in conscious monkeys.
Synapse (New York, N.Y.) 2001;40(3):170-9.
2001: Shingo Nishiyama; Hideo Tsukada; Kengo Sato; Takeharu Kakiuchi; Hiroyuki Ohba; Norihiro Harada; K Takahashi
Evaluation of PET ligands (+)N-[(11)C]ethyl-3-piperidyl benzilate and (+)N-[(11)C]propyl-3-piperidyl benzilate for muscarinic cholinergic receptors: a PET study with microdialysis in comparison with (+)N-[(11)C]methyl-3-piperidyl benzilate in the conscious monkey brain.
Synapse (New York, N.Y.) 2001;40(3):159-69.
2001: Hideo Tsukada; K Takahashi; S Miura; Shingo Nishiyama; Takeharu Kakiuchi; Hiroyuki Ohba; Kengo Sato; J Hatazawa; T Okudera
Evaluation of novel PET ligands (+)N-[11C]methyl-3-piperidyl benzilate ([11C](+)3-MPB) and its stereoisomer [11C](-)3-MPB for muscarinic cholinergic receptors in the conscious monkey brain: a PET study in comparison with.
Synapse (New York, N.Y.) 2001;39(2):182-92.
2000: Takeharu Kakiuchi; Shingo Nishiyama; Kengo Sato; Hiroyuki Ohba; S Nakanishi; Hideo Tsukada
Age-related reduction of [11C]MDL100,907 binding to central 5-HT(2A) receptors: PET study in the conscious monkey brain.
Brain research 2000;883(1):135-42.
2000: Shingo Nishiyama; Kengo Sato; Norihiro Harada; Takeharu Kakiuchi; Hideo Tsukada
Development and evaluation of muscarinic cholinergic receptor ligands N-[11C]ethyl-4-piperidyl benzilate and N-[11C]propyl-4-piperidyl benzilate: a PET study in comparison with N-[11C]methyl-4-piperidyl benzilate in the conscious monkey brain.
Nuclear medicine and biology 2000;27(8):733-40.
2000: Hideo Tsukada; Norihiro Harada; Shingo Nishiyama; Hiroyuki Ohba; Takeharu Kakiuchi
Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):7067-73.
2000: Hideo Tsukada; Norihiro Harada; Shingo Nishiyama; Hiroyuki Ohba; Kengo Sato; Dai Fukumoto; Takeharu Kakiuchi
Ketamine decreased striatal [(11)C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: multiparametric PET studies combined with microdialysis analysis.
Synapse (New York, N.Y.) 2000;37(2):95-103.
2000: Hideo Tsukada; Takeharu Kakiuchi; Dai Fukumoto; Shingo Nishiyama; K Koga
Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeys.
Brain research 2000;862(1-2):180-6.
2000: Hideo Tsukada; Norihiro Harada; Shingo Nishiyama; Hiroyuki Ohba; Takeharu Kakiuchi
Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis.
Brain research 2000;860(1-2):141-8.
2000: Hideo Tsukada; Kengo Sato; Takeharu Kakiuchi; Shingo Nishiyama
Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain.
Brain research 2000;857(1-2):158-64.
1999: Hideo Tsukada; Shingo Nishiyama; Takeharu Kakiuchi; Hiroyuki Ohba; Kengo Sato; Norihiro Harada; S Nakanishi
Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain.
Brain research 1999;849(1-2):85-96.
1999: Hideo Tsukada; Shingo Nishiyama; Takeharu Kakiuchi; Hiroyuki Ohba; Kengo Sato; Norihiro Harada
Is synaptic dopamine concentration the exclusive factor which alters the in vivo binding of [11C]raclopride?: PET studies combined with microdialysis in conscious monkeys.
Brain research 1999;841(1-2):160-9.
1999: Hideo Tsukada; S Yamazaki; A Noda; T Inoue; N Matsuoka; Takeharu Kakiuchi; Shingo Nishiyama; S Nishimura
FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel potential antidementia drug, restores the regional cerebral blood flow response abolished by scopolamine but not by HA-966: a positron emission tomography study with unanesthetized rhesus monkeys.
Brain research 1999;832(1-2):118-23.
1998: Hideo Tsukada; Takeharu Kakiuchi; H Shizuno; Shingo Nishiyama
Interactions of cholinergic and glutamatergic neuronal systems in the functional activation of cerebral blood flow response: a PET study in unanesthetized monkeys.
Brain research 1998;796(1-2):82-90.
1998: C Seki; H Okada; S Mori; Takeharu Kakiuchi; Etsuji Yoshikawa; Shingo Nishiyama; Hideo Tsukada; T Yamashita
Application of a beta microprobe for quantification of regional cerebral blood flow with (15)O-water and PET in rhesus monkeys.
Annals of nuclear medicine 1998;12(1):7-14.
1997: Hideo Tsukada; Takeharu Kakiuchi; I Ando; Y Ouchi
Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys.
The Journal of pharmacology and experimental therapeutics 1997;281(3):1408-14.
1997: Hideo Tsukada; Takeharu Kakiuchi; I Ando; H Shizuno; S Nakanishi; Y Ouchi
Regulation of cerebral blood flow response to somatosensory stimulation through the cholinergic system: a positron emission tomography study in unanesthetized monkeys.
Brain research 1997;749(1):10-7.
1996: Hideo Tsukada; J Kreuter; CE Maggos; Ellen M Unterwald; Takeharu Kakiuchi; Shingo Nishiyama; M Futatsubashi; Mary Jeanne Kreek
Effects of binge pattern cocaine administration on dopamine D1 and D2 receptors in the rat brain: an in vivo study using positron emission tomography.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(23):7670-7.
1996: Hideo Tsukada; KJ Lindner; Per Hartvig; Y Tani; Johann Valtysson; P Bjurling; Tor Kihlberg; G Westerberg; Yasuyoshi Watanabe; Bengt Långström
Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin and infusion of L-tyrosine on the in vivo L-[beta-11C] DOPA disposition in the monkey brain.
Brain research 1996;713(1-2):92-8.
1994: Hideo Tsukada; KJ Lindner; Per Hartvig; Y Tani; P Bjurling; Tor Kihlberg; G Westerberg; Yasuyoshi Watanabe; Bengt Långström
Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on in vivo L-[beta-11C]dopa turnover in the rat striatum with infusion of L-tyrosine.
Journal of neural transmission. General section 1994;95(1):1-15.
1993: Per Hartvig; Joakim Tedroff; KJ Lindner; P Bjurling; C W Chang; Hideo Tsukada; Y Watanabe; Bengt Långström
Positron emission tomographic studies on aromatic L-amino acid decarboxylase activity in vivo for L-dopa and 5-hydroxy-L-tryptophan in the monkey brain.
Journal of neural transmission. General section 1993;94(2):127-35.