Takashi Tsuruo

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Colonic Neoplasms

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TOP 3
Togano Tomiteru; Sasaki Masataka; Watanabe Mariko; Nakashima Makoto; Tsuruo Takashi; Umezawa Kazuo; Higashihara Masaaki; Watanabe Toshiki; Horie Ryouichi
Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.
Katayama Ryohei; Koike Sumie; Sato Shigeo; Sugimoto Yoshikazu; Tsuruo Takashi; Fujita Naoya
Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export.
Schulz Ramona; Vogel Tanja; Mashima Tetsuo; Tsuruo Takashi; Krieglstein Kerstin
Involvement of Fractin in TGF-beta-induced apoptosis in oligodendroglial progenitor cells.

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All Publications

2009: Togano Tomiteru; Sasaki Masataka; Watanabe Mariko; Nakashima Makoto; Tsuruo Takashi; Umezawa Kazuo; Higashihara Masaaki; Watanabe Toshiki; Horie Ryouichi
Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.
Biochemical and biophysical research communications 2009;390(1):60-4.
2009: Katayama Ryohei; Koike Sumie; Sato Shigeo; Sugimoto Yoshikazu; Tsuruo Takashi; Fujita Naoya
Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export.
Cancer science 2009;100(11):2060-8.
2009: Schulz Ramona; Vogel Tanja; Mashima Tetsuo; Tsuruo Takashi; Krieglstein Kerstin
Involvement of Fractin in TGF-beta-induced apoptosis in oligodendroglial progenitor cells.
Glia 2009;57(15):1619-29.
2009: Tsukumo Yoshinori; Tsukahara Satomi; Saito Sakae; Tsuruo Takashi; Tomida Akihiro
A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site.
The Journal of biological chemistry 2009;284(40):27500-10.
2009: Mashima Tetsuo; Sato Shigeo; Okabe Sachiko; Miyata Satoshi; Matsuura Masaaki; Sugimoto Yoshikazu; Tsuruo Takashi; Seimiya Hiroyuki
Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide.
Cancer science 2009;100(8):1556-62.
2009: Demers Marie-Josée; Thibodeau Sonya; Noël Dominique; Fujita Naoya; Tsuruo Takashi; Gauthier Rémy; Arguin Mélina; Vachon Pierre H
Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1.
Journal of cellular biochemistry 2009;107(4):639-54.
2009: Miyawaki Jin; Matsumura Sachiko; Yuge Ryota; Murakami Tatsuya; Sato Shigeo; Tomida Akihiro; Tsuruo Takashi; Ichihashi Toshinari; Fujinami Takako; Irie Hiroshi; Tsuchida Kunihiro; Iijima Sumio; Shiba Kiyotaka; Yudasaka Masako
Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd2O3 labels.
ACS nano 2009;3(6):1399-406.
2009: Saito Sakae; Furuno Aki; Sakurai Junko; Sakamoto Asami; Park Hae-Ryong; Shin-Ya Kazuo; Tsuruo Takashi; Tomida Akihiro
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.
Cancer research 2009;69(10):4225-34.
2009: Mashima T; Seimiya H; Tsuruo T
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy.
British journal of cancer 2009;100(9):1369-72.
2009: Tanaka Hiroshi; Hoshikawa Yutaka; Oh-hara Tomoko; Koike Sumie; Naito Mikihiko; Noda Tetsuo; Arai Hiroyuki; Tsuruo Takashi; Fujita Naoya
PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via nuclear factor-kappaB activation.
Molecular cancer research : MCR 2009;7(4):557-69.
2009: Matsumura Sachiko; Sato Shigeo; Yudasaka Masako; Tomida Akihiro; Tsuruo Takashi; Iijima Sumio; Shiba Kiyotaka
Prevention of carbon nanohorn agglomeration using a conjugate composed of comb-shaped polyethylene glycol and a peptide aptamer.
Molecular pharmaceutics 2009;6(2):441-7.
2009: Mashima T; Sato S; Sugimoto Y; Tsuruo T; Seimiya H
Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.
Oncogene 2009;28(1):9-19.
2008: Tsuruo Takashi; Tsujimoto Gozoh; Yamamoto Hiroshi
[Introduction to the symposium "Bio-informatics for Pharmaceutical Sciences and Pharmacy Education". Foreword]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008;128(11):1517.
2008: Nakasaki Tae; Tanaka Toshiyuki; Okudaira Shinichi; Hirosawa Michi; Umemoto Eiji; Otani Kazuhiro; Jin Soojung; Bai Zhongbin; Hayasaka Haruko; Fukui Yoshinori; Aozasa Katsuyuki; Fujita Naoya; Tsuruo Takashi; Ozono Keiichi; Aoki Junken; Miyasaka Masayuki
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions.
The American journal of pathology 2008;173(5):1566-76.
2008: Isomura Minoru; Oya Natsuo; Tachiiri Seiji; Kaneyasu Yuko; Nishimura Yasumasa; Akimoto Tetsuo; Hareyama Masato; Sugita Tadasi; Mitsuhashi Norio; Yamashita Takashi; Aoki Masahiko; Sai Heitetsu; Hirokawa Yutaka; Sakata Koh-Ichi; Karasawa Kumiko; Tomida Akihiro; Tsuruo Takashi; Miki Yoshio; Noda Tetsuo; Hiraoka Masahiro
IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6683-9.
2008: Nakamura Akito; Naito Mikihiko; Tsuruo Takashi; Fujita Naoya
Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling.
Molecular and cellular biology 2008;28(19):5996-6009.
2008: Kurata Atsuo; Katayama Ryohei; Watanabe Toshiki; Tsuruo Takashi; Fujita Naoya
TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
Cancer science 2008;99(9):1827-34.
2008: Nakazawa Youya; Sato Shigeo; Naito Mikihiko; Kato Yukinari; Mishima Kazuhiko; Arai Hiroyuki; Tsuruo Takashi; Fujita Naoya
Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.
Blood 2008;112(5):1730-9.
2008: Tsuruo Takashi
[Pharmacogenomics: challenges in promoting its clinical usage]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2008;132(1):31-8.
2008: Morishita Daisuke; Katayama Ryohei; Sekimizu Kazuhisa; Tsuruo Takashi; Fujita Naoya
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
Cancer research 2008;68(13):5076-85.
2008: Bouchard Véronique; Harnois Charlène; Demers Marie-Josée; Thibodeau Sonya; Laquerre Vincent; Gauthier Rémy; Vézina Anne; Noël Dominique; Fujita Naoya; Tsuruo Takashi; Arguin Mélina; Vachon Pierre H
B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms.
Apoptosis : an international journal on programmed cell death 2008;13(4):531-42.
2008: Sekine Keiko; Takubo Kohei; Kikuchi Ryo; Nishimoto Michie; Kitagawa Masayuki; Abe Fuminori; Nishikawa Kiyohiro; Tsuruo Takashi; Naito Mikihiko
Small molecules destabilize cIAP1 by activating auto-ubiquitylation.
The Journal of biological chemistry 2008;283(14):8961-8.
2008: Muramatsu Yukiko; Tahara Hidetoshi; Ono Taeko; Tsuruo Takashi; Seimiya Hiroyuki
Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation.
Experimental cell research 2008;314(5):1115-24.
2008: Akaza Hideyuki; Kawai Koji; Tsuruo Takashi; Tsukagoshi Shigeru; Aiba Keisuke; Shimada Yasuhiro; Kakeji Yoshihiro; Ishikawa Hideki; Ikeda Tadashi; Nakamura Seigo; Tamura Tomohide; Yamamoto Nobuyuki; Isonishi Seiji; Hinotsu Shiro; Hirose Masaru; Katsura Jun
[Future directions of anticancer drug development in Japan]
Gan to kagaku ryoho. Cancer & chemotherapy 2008;35(2):351-60.
2008: Wang Liyan; Bai Liming; Nagasawa Takashi; Hasegawa Toshiaki; Yang Xiaoyang; Sakai Jun-ichi; Bai Yuhua; Kataoka Takao; Oka Seiko; Hirose Katsutoshi; Tomida Akihiro; Tsuruo Takashi; Ando Masayoshi
Bioactive triterpene saponins from the roots of Phytolacca americana.
Journal of natural products 2008;71(1):35-40.
2008: Tsuruo Takashi; Fujita Naoya
Platelet aggregation in the formation of tumor metastasis.
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2008;84(6):189-98.
2007: Huang Lin; Shitashige Miki; Satow Reiko; Honda Kazufumi; Ono Masaya; Yun Jisoo; Tomida Akihiro; Tsuruo Takashi; Hirohashi Setsuo; Yamada Tesshi
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
Gastroenterology 2007;133(5):1569-78.
2007: Dohgu Shinya; Nishioku Tsuyoshi; Sumi Noriko; Takata Fuyuko; Nakagawa Shinsuke; Naito Mikihiko; Tsuruo Takashi; Yamauchi Atsushi; Shuto Hideki; Kataoka Yasufumi
Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro.
Cellular and molecular neurobiology 2007;27(7):889-99.
2007: Tokuda Emi; Fujita Naoya; Oh-hara Tomoko; Sato Shigeo; Kurata Atsuo; Katayama Ryohei; Itoh Toshiki; Takenawa Tadaomi; Miyazono Kohei; Tsuruo Takashi
Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.
Cancer research 2007;67(20):9666-76.
2007: Tsukumo Yoshinori; Tomida Akihiro; Kitahara Osamu; Nakamura Yusuke; Asada Shinichi; Mori Kazutoshi; Tsuruo Takashi
Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation.
The Journal of biological chemistry 2007;282(40):29264-72.
2007: Takahashi Shunji; Aiba Keisuke; Ito Yoshinori; Hatake Kiyohiko; Nakane Minoru; Kobayashi Takayuki; Minowa Sayuri; Shibata Harumi; Mitsuhashi Junko; Tsukahara Satomi; Ishikawa Etsuko; Suzuki Rieko; Tsuruo Takashi; Sugimoto Yoshikazu
Pilot study of MDR1 gene transfer into hematopoietic stem cells and chemoprotection in metastatic breast cancer patients.
Cancer science 2007;98(10):1609-16.
2007: Ichikawa Kazuhiro; Sakabe Emiko; Kuninobu Ken-Ichiro; Yamori Takao; Tsuruo Takashi; Yao Takashi; Tsuneyoshi Masazumi; Utsumi Hideo
Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad.
Antioxidants & redox signaling 2007;9(10):1699-707.
2007: Ohtani Hisakazu; Ikegawa Tomomi; Honda Youko; Kohyama Noriko; Morimoto Satoshi; Shoyama Yukihiro; Juichi Motoharu; Naito Mikihiko; Tsuruo Takashi; Sawada Yasufumi
Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells.
Pharmaceutical research 2007;24(10):1936-43.
2007: Ishizu Kazuhiro; Sunose Naohide; Yamazaki Kanami; Tsuruo Takashi; Sadahiro Sotaro; Makuuchi Hiroyasu; Yamori Takao
Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.
Biological & pharmaceutical bulletin 2007;30(9):1779-83.
2007: Bouchard Véronique; Demers Marie-Josée; Thibodeau Sonya; Laquerre Vincent; Fujita Naoya; Tsuruo Takashi; Beaulieu Jean-François; Gauthier Rémy; Vézina Anne; Villeneuve Lisabeth; Vachon Pierre H
Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways.
Journal of cellular physiology 2007;212(3):717-28.
2007: Zembutsu Hitoshi; Yanada Masamitsu; Hishida Asahi; Katagiri Toyomasa; Tsuruo Takashi; Sugiura Isamu; Takeuchi Jin; Usui Noriko; Naoe Tomoki; Nakamura Yusuke; Ohno Ryuzo
Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy.
International journal of oncology 2007;31(2):313-22.
2007: Zhao Ming; Bai Liming; Wang Liyan; Toki Asami; Hasegawa Toshiaki; Kikuchi Midori; Abe Mariko; Sakai Jun-ichi; Hasegawa Ryo; Bai Yuhua; Mitsui Tomokazu; Ogura Hirotsugu; Kataoka Takao; Oka Seiko; Tsushima Hiroko; Kiuchi Miwa; Hirose Katutoshi; Tomida Akihiro; Tsuruo Takashi; Ando Masayoshi
Bioactive cardenolides from the stems and twigs of Nerium oleander.
Journal of natural products 2007;70(7):1098-103.
2007: Hasegawa Toshiaki; Bai Jiao; Dai Jungui; Bai Liming; Sakai Junichi; Nishizawa Shigenori; Bai Yuhua; Kikuchi Midori; Abe Mariko; Yamori Takao; Tomida Akihiro; Tsuruo Takashi; Hirose Katsutoshi; Ando Masayoshi
Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
Bioorganic & medicinal chemistry letters 2007;17(13):3722-8.
2007: Rosner Margit; Freilinger Angelika; Hanneder Michaela; Fujita Naoya; Lubec Gert; Tsuruo Takashi; Hengstschläger Markus
p27Kip1 localization depends on the tumor suppressor protein tuberin.
Human molecular genetics 2007;16(13):1541-56.
2007: Ishioka Toshiyasu; Katayama Ryohei; Kikuchi Ryo; Nishimoto Michie; Takada Shinji; Takada Ritsuko; Matsuzawa Shu-ichi; Reed John C; Tsuruo Takashi; Naito Mikihiko
Impairment of the ubiquitin-proteasome system by cellular FLIP.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(6):735-44.
2007: Li Na; Wu Jian-lin; Hasegawa Toshiaki; Sakai Jun-ichi; Bai Li-ming; Wang Li-yan; Kakuta Saori; Furuya Yumiko; Ogura Hirotsugu; Kataoka Takao; Tomida Akihiro; Tsuruo Takashi; Ando Masayoshi
Bioactive polyketides from Peperomia duclouxii.
Journal of natural products 2007;70(6):998-1001.
2007: Muramatsu Yukiko; Ohishi Tomokazu; Sakamoto Michiko; Tsuruo Takashi; Seimiya Hiroyuki
Cross-species difference in telomeric function of tankyrase 1.
Cancer science 2007;98(6):850-7.
2007: Yamauchi Atsushi; Dohgu Shinya; Nishioku Tsuyoshi; Shuto Hideki; Naito Mikihiko; Tsuruo Takashi; Sawada Yasufumi; Kataoka Yasufumi
An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function.
Cellular and molecular neurobiology 2007;27(3):263-70.
2007: Doh-ura Katsumi; Tamura Kazuhiko; Karube Yoshiharu; Naito Mikihiko; Tsuruo Takashi; Kataoka Yasufumi
Chelating compound, chrysoidine, is more effective in both antiprion activity and brain endothelial permeability than quinacrine.
Cellular and molecular neurobiology 2007;27(3):303-16.
2007: Takata Fuyuko; Dohgu Shinya; Yamauchi Atsushi; Sumi Noriko; Nakagawa Shinsuke; Naito Mikihiko; Tsuruo Takashi; Shuto Hideki; Kataoka Yasufumi
Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier.
Cellular and molecular neurobiology 2007;27(3):317-28.
2007: Kunita Akiko; Kashima Takeshi G; Morishita Yasuyuki; Fukayama Masashi; Kato Yukinari; Tsuruo Takashi; Fujita Naoya
The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis.
The American journal of pathology 2007;170(4):1337-47.
2007: Li Na; Wu Jian-Lin; Hasegawa Toshiaki; Sakai Jun-Ichi; Bai Li-Ming; Wang Li-Yan; Kakuta Saori; Furuya Yumiko; Ogura Hirotsugu; Kataoka Takao; Tomida Akihiro; Tsuruo Takashi; Ando Masayoshi
Bioactive lignans from Peperomia duclouxii.
Journal of natural products 2007;70(4):544-8.
2007: Nishioku Tsuyoshi; Takata Fuyuko; Yamauchi Atsushi; Sumi Noriko; Yamamoto Ikumi; Fujino Akiko; Naito Mikihiko; Tsuruo Takashi; Shuto Hideki; Kataoka Yasufumi
Protective action of indapamide, a thiazide-like diuretic, on ischemia-induced injury and barrier dysfunction in mouse brain microvascular endothelial cells.
Journal of pharmacological sciences 2007;103(3):323-7.
2007: Hasegawa Toshiaki; Bai Jao; Zhang Shujun; Wang Jinlan; Matsubara Junichi; Kawakami Junichi; Tomida Akihiro; Tsuruo Takashi; Hirose Katsutoshi; Sakai Junichi; Kikuchi Midori; Abe Mariko; Ando Masayoshi
Structure-activity relationships of some taxoids as multidrug resistance modulator.
Bioorganic & medicinal chemistry letters 2007;17(4):1122-6.
2007: Saeki Toshiaki; Nomizu Tadashi; Toi Masakazu; Ito Yoshinori; Noguchi Shinzaburo; Kobayashi Tadashi; Asaga Taro; Minami Hironobu; Yamamoto Naohito; Aogi Kenjiro; Ikeda Tadashi; Ohashi Yasuo; Sato Wakao; Tsuruo Takashi
Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracil for patients with advanced or recurrent breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(4):411-7.
2007: Kamo Naoko; Yasuchika Kentaro; Fujii Hideaki; Hoppo Toshitaka; Machimoto Takafumi; Ishii Takamichi; Fujita Naoya; Tsuruo Takashi; Yamashita Jun K; Kubo Hajime; Ikai Iwao
Two populations of Thy1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(2):G526-34.
2007: Tsuruo Takashi
The centennial of Cancer Science.
Cancer science 2007;98(1):1-4; discussion 5.
2007: Ohishi Tomokazu; Tsuruo Takashi; Seimiya Hiroyuki
Evaluation of tankyrase inhibition in whole cells.
Methods in molecular biology (Clifton, N.J.) 2007;405():133-46.
2006: Kono Tomoya; Kubo Hajime; Shimazu Chikashi; Ueda Yoshihide; Takahashi Meiko; Yanagi Kentoku; Fujita Naoya; Tsuruo Takashi; Wada Hiromi; Yamashita Jun K
Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(9):2070-6.
2006: Mishima Kazuhiko; Kato Yukinari; Kaneko Mika K; Nakazawa Youya; Kunita Akiko; Fujita Naoya; Tsuruo Takashi; Nishikawa Ryo; Hirose Takanori; Matsutani Masao
Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma.
Acta neuropathologica 2006;111(6):563-8.
2006: Dai Jungui; Bai Jiao; Hasegawa Toshiaki; Nishizawa Shigenori; Sakai Junichi; Oka Seiko; Kiuchi Miwa; Hirose Katutoshi; Tomida Akihiro; Tsuruo Takashi; Li Minjie; Ando Masayoshi
A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent.
Chemical & pharmaceutical bulletin 2006;54(3):306-9.
2006: Tahara H; Shin-Ya K; Seimiya H; Yamada H; Tsuruo T; Ide T
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.
Oncogene 2006;25(13):1955-66.
2006: Li Na; Wu Jian-Lin; Hasegawa Toshiaki; Sakai Jun-ichi; Wang Li-yan; Kakuta Saori; Furuya Yumiko; Tomida Akihiro; Tsuruo Takashi; Ando Masayoshi
Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii.
Journal of natural products 2006;69(2):234-9.
2006: Nozawa Kohei; Tsuda Masashi; Ishiyama Haruaki; Sasaki Takuma; Tsuruo Takashi; Kobayashi Jun'ichi
Absolute stereochemistry and antitumor activity of iejimalides.
Bioorganic & medicinal chemistry 2006;14(4):1063-7.
2005: Mashima Tetsuo; Tsuruo Takashi
Defects of the apoptotic pathway as therapeutic target against cancer.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(6):339-43.
2005: Tanaka Hiroshi; Fujita Naoya; Tsuruo Takashi
3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.
The Journal of biological chemistry 2005;280(49):40965-73.
2005: Wu Jian-lin; Li Na; Hasegawa Toshiaki; Sakai Jun-ichi; Kakuta Saori; Tang Wanxia; Oka Seiko; Kiuchi Miwa; Ogura Hirotsugu; Kataoka Takao; Tomida Akihiro; Tsuruo Takashi; Ando Masayoshi
Bioactive tetrahydrofuran lignans from Peperomia dindygulensis.
Journal of natural products 2005;68(11):1656-60.
2005: Saeki Toshiaki; Tsuruo Takashi; Sato Wakao; Nishikawsa Kiyoshiro
Drug resistance in chemotherapy for breast cancer.
Cancer chemotherapy and pharmacology 2005;56 Suppl 1():84-9.
2005: Haga Naomi; Fujita Naoya; Tsuruo Takashi
Involvement of mitochondrial aggregation in arsenic trioxide (As2O3)-induced apoptosis in human glioblastoma cells.
Cancer science 2005;96(11):825-33.
2005: Akaza Hideyuki; Tsuruo Takashi; Saijo Nagahiro; Sone Saburo; Isonishi Seiji; Ohashi Yasuo; Noguchi Shinzaburo; Kurebayashi Junichi; Kakehi Yoshiyuki; Ishikawa Hideki; Blackledge George
[Cancer prevention]
Gan to kagaku ryoho. Cancer & chemotherapy 2005;32(10):1499-506.
2005: Goswami Anindya; Burikhanov Ravshan; de Thonel Aurelie; Fujita Naoya; Goswami Mamta; Zhao Yanming; Eriksson John E; Tsuruo Takashi; Rangnekar Vivek M
Binding and phosphorylation of par-4 by akt is essential for cancer cell survival.
Molecular cell 2005;20(1):33-44.
2005: Kanemitsu Naotoshi; Ebisuno Yukihiko; Tanaka Toshiyuki; Otani Kazuhiro; Hayasaka Haruko; Kaisho Tsuneyasu; Akira Shizuo; Katagiri Koko; Kinashi Tatsuo; Fujita Naoya; Tsuruo Takashi; Miyasaka Masayuki
CXCL13 is an arrest chemokine for B cells in high endothelial venules.
Blood 2005;106(8):2613-8.
2005: Kato Yukinari; Kaneko Mika; Sata Makoto; Fujita Naoya; Tsuruo Takashi; Osawa Motoki
Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2005;26(4):195-200.
2005: Guleng Bayasi; Tateishi Keisuke; Ohta Miki; Kanai Fumihiko; Jazag Amarsanaa; Ijichi Hideaki; Tanaka Yasuo; Washida Miwa; Morikane Keita; Fukushima Yasushi; Yamori Takao; Tsuruo Takashi; Kawabe Takao; Miyagishi Makoto; Taira Kazunari; Sata Masataka; Omata Masao
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner.
Cancer research 2005;65(13):5864-71.
2005: Katayama Kazuhiro; Fujita Naoya; Tsuruo Takashi
Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition.
Molecular and cellular biology 2005;25(13):5725-37.
2005: Tsuruo Takashi
Tumorigenesis facilitated by Pten deficiency in the skin: evidence of p53-Pten complex formation on the initiation phase.
Cancer science 2005;96(6):377.
2005: Aoyagi Yumiko; Fujita Naoya; Tsuruo Takashi
Stabilization of integrin-linked kinase by binding to Hsp90.
Biochemical and biophysical research communications 2005;331(4):1061-8.
2005: Mashima Tetsuo; Oh-hara Tomoko; Sato Shigeo; Mochizuki Mikiko; Sugimoto Yoshikazu; Yamazaki Kanami; Hamada Jun-ichi; Tada Mitsuhiro; Moriuchi Tetsuya; Ishikawa Yuichi; Kato Yo; Tomoda Hiroshi; Yamori Takao; Tsuruo Takashi
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
Journal of the National Cancer Institute 2005;97(10):765-77.
2005: Bai Jiao; Ito Nobuhide; Sakai Junichi; Kitabatake Mutumi; Fujisawa Hajime; Bai Liming; Dai Jungui; Zhang Shujun; Hirose Katutoshi; Tomida Akihiro; Tsuruo Takashi; Ando Masayoshi
Taxoids and abietanes from callus cultures of Taxus cuspidata.
Journal of natural products 2005;68(4):497-501.
2005: Sekine Keiko; Hao Yanyan; Suzuki Yasuyuki; Takahashi Ryosuke; Tsuruo Takashi; Naito Mikihiko
HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.
Biochemical and biophysical research communications 2005;330(1):279-85.
2005: Dohgu Shinya; Takata Fuyuko; Yamauchi Atsushi; Nakagawa Shinsuke; Egawa Takashi; Naito Mikihiko; Tsuruo Takashi; Sawada Yasufumi; Niwa Masami; Kataoka Yasufumi
Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.
Brain research 2005;1038(2):208-15.
2005: Syed Viqar; Mukherjee Kasturi; Lyons-Weiler James; Lau Kin-Mang; Mashima Tetsuo; Tsuruo Takashi; Ho Shuk-mei
Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling.
Oncogene 2005;24(10):1774-87.
2005: Sung Jong-Hyuk; Yu Kyung-Ha; Park Jin-Sun; Tsuruo Takashi; Kim Dae-Duk; Shim Chang-Koo; Chung Suk-Jae
Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(3):440-8.
2005: Murakami Hideyasu; Ohkura Airi; Takanaga Hitomi; Matsuo Hirotami; Koyabu Noriko; Naito Mikihiko; Tsuruo Takashi; Ohtani Hisakazu; Sawada Yasufumi
Functional characterization of adenosine transport across the BBB in mice.
International journal of pharmaceutics 2005;290(1-2):37-44.
2005: Akaza Hideyuki; Tsuruo Takashi; Saijo Nagahiro; Sone Saburo; Isonishi Seiji; Ohashi Yasuo; Sobue Tomotaka; Yamanaka Hidetoshi; Fukuda Mamoru; Maruyama Masakazu; Eguchi Kenji; Ito Kazuto; Smith Mark; Milsted Bob
[Cancer screening]
Gan to kagaku ryoho. Cancer & chemotherapy 2005;32(1):125-34.
2005: Seimiya Hiroyuki; Muramatsu Yukiko; Ohishi Tomokazu; Tsuruo Takashi
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Cancer cell 2005;7(1):25-37.
2004: Kakiuchi Soji; Daigo Yataro; Ishikawa Nobuhisa; Furukawa Chiyuki; Tsunoda Tatsuhiko; Yano Seiji; Nakagawa Kazuhiko; Tsuruo Takashi; Kohno Nobuoki; Fukuoka Masahiro; Sone Saburo; Nakamura Yusuke
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).
Human molecular genetics 2004;13(24):3029-43.
2004: Dohgu Shinya; Yamauchi Atsushi; Nakagawa Shinsuke; Takata Fuyuko; Kai Mamiko; Egawa Takashi; Naito Mikihiko; Tsuruo Takashi; Sawada Yasufumi; Niwa Masami; Kataoka Yasufumi
Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes.
European journal of pharmacology 2004;505(1-3):51-9.
2004: Kato Yukinari; Sasagawa Isoji; Kaneko Mika; Osawa Motoki; Fujita Naoya; Tsuruo Takashi
Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors.
Oncogene 2004;23(52):8552-6.
2004: Naito Mikihiko; Katayama Ryohei; Ishioka Toshiyasu; Suga Akiko; Takubo Kohei; Nanjo Masahiro; Hashimoto Chizuko; Taira Masanori; Takada Shinji; Takada Ritsuko; Kitagawa Masatoshi; Matsuzawa Shu-Ichi; Reed John C; Tsuruo Takashi
Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling.
Molecular and cellular biology 2004;24(19):8418-27.
2004: Dufour Geneviève; Demers Marie-Josée; Gagné David; Dydensborg Anders Bondo; Teller Inga C; Bouchard Véronique; Degongre Isabelle; Beaulieu Jean-François; Cheng Jin Q; Fujita Naoya; Tsuruo Takashi; Vallée Karine; Vachon Pierre H
Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms.
The Journal of biological chemistry 2004;279(42):44113-22.
2004: Uchiyama-Kokubu Noriko; Naito Mikihiko; Nakajima Motowo; Tsuruo Takashi
Transport of somatostatin and substance P by human P-glycoprotein.
FEBS letters 2004;574(1-3):55-61.
2004: Motiwala Tasneem; Kutay Huban; Ghoshal Kalpana; Bai Shoumei; Seimiya Hiroyuki; Tsuruo Takashi; Suster Saul; Morrison Carl; Jacob Samson T
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13844-9.
2004: Park Hae-Ryong; Tomida Akihiro; Sato Shigeo; Tsukumo Yoshinori; Yun Jisoo; Yamori Takao; Hayakawa Yoichi; Tsuruo Takashi; Shin-ya Kazuo
Effect on tumor cells of blocking survival response to glucose deprivation.
Journal of the National Cancer Institute 2004;96(17):1300-10.
2004: Hao Yanyan; Sekine Keiko; Kawabata Atsushi; Nakamura Hitoshi; Ishioka Toshiyasu; Ohata Hirokazu; Katayama Ryohei; Hashimoto Chizuko; Zhang Xiaodong; Noda Tetsuo; Tsuruo Takashi; Naito Mikihiko
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function.
Nature cell biology 2004;6(9):849-60.
2004: Kaneko Mika; Kato Yukinari; Kunita Akiko; Fujita Naoya; Tsuruo Takashi; Osawa Motoki
Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells.
The Journal of biological chemistry 2004;279(37):38838-43.
2004: Koyabu Noriko; Takanaga Hitomi; Matsuo Hirotami; Naito Mikihiko; Tsuruo Takashi; Ohtani Hisakazu; Sawada Yasufumi
Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line.
Drug metabolism and pharmacokinetics 2004;19(4):270-9.
2004: Sato Saori; Fujita Naoya; Tsuruo Takashi
Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway.
The Journal of biological chemistry 2004;279(32):33759-67.
2004: Yun Jisoo; Tomida Akihiro; Andoh Toshiwo; Tsuruo Takashi
Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.
The Journal of biological chemistry 2004;279(30):31296-303.
2004: Dohgu Shinya; Yamauchi Atsushi; Takata Fuyuko; Naito Mikihiko; Tsuruo Takashi; Higuchi Shun; Sawada Yasufumi; Kataoka Yasufumi
Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells.
Cellular and molecular neurobiology 2004;24(3):491-7.
2004: Dohgu Shinya; Yamauchi Atsushi; Takata Fuyuko; Sawada Yasufumi; Higuchi Shun; Naito Mikihiko; Tsuruo Takashi; Shirabe Susumu; Niwa Masami; Katamine Shigeru; Kataoka Yasufumi
Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier.
Cellular and molecular neurobiology 2004;24(2):205-17.
2004: Akaza Hideyuki; Nakagawa Masayuki; Tsuruo Takashi; Saijo Nagahiro; Sone Saburo; Yamamoto Nobuyuki; Kakeji Yoshihiro; Nakamura Seigo; Kurebayashi Junichi; Isonishi Seiji; Ohashi Yasuo; Blackledge George; Carmichael James
[Anti angiogenesis]
Gan to kagaku ryoho. Cancer & chemotherapy 2004;31(4):647-55.
2004: Naito Mikihiko; Hashimoto Chizuko; Masui Shigeki; Tsuruo Takashi
Caspase-independent necrotic cell death induced by a radiosensitizer, 8-nitrocaffeine.
Cancer science 2004;95(4):361-6.
2004: Lee Yong J; Froelich Christopher J; Fujita Naoya; Tsuruo Takashi; Kim Jin H
Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):1894-900.
2004: Yamaji Ryoichi; Fujita Kayoko; Nakanishi Isao; Nagao Kaori; Naito Mikihiko; Tsuruo Takashi; Inui Hiroshi; Nakano Yoshihisa
Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells.
Archives of biochemistry and biophysics 2004;423(2):332-42.
2004: Seimiya Hiroyuki; Muramatsu Yukiko; Smith Susan; Tsuruo Takashi
Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation.
Molecular and cellular biology 2004;24(5):1944-55.
2004: Yasui Kohichiroh; Mihara Saori; Zhao Chen; Okamoto Hiroyuki; Saito-Ohara Fumiko; Tomida Akihiro; Funato Tadao; Yokomizo Akira; Naito Seiji; Imoto Issei; Tsuruo Takashi; Inazawa Johji
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer research 2004;64(4):1403-10.
2004: Zhang Hua-Feng; Tomida Akihiro; Koshimizu Ritsuko; Ogiso Yasunari; Lei Shuhong; Tsuruo Takashi
Cullin 3 promotes proteasomal degradation of the topoisomerase I-DNA covalent complex.
Cancer research 2004;64(3):1114-21.
2004: Ahn Sung-Hoon; Jeon Seng-Ho; Tsuruo Takashi; Shim Chang-Koo; Chung Suk-Jae
Pharmacokinetic characterization of dehydroevodiamine in the rat brain.
Journal of pharmaceutical sciences 2004;93(2):283-92.
2004: Harnois Charlène; Demers Marie-Josée; Bouchard Véronique; Vallée Karine; Gagné David; Fujita Naoya; Tsuruo Takashi; Vézina Anne; Beaulieu Jean-François; Côté André; Vachon Pierre H
Human intestinal epithelial crypt cell survival and death: Complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways.
Journal of cellular physiology 2004;198(2):209-22.
2004: Akaza Hideyuki; Ichikawa Tomohiko; Tsuruo Takashi; Shimada Yasuhiro; Moriwaki Hisataka; Mori Masaki; Noguchi Shinzaburo; Nakamura Seigo; Saijo Nagahiro; Sone Saburo; Isonishi Seiji; Ohashi Yasuo; Hinotsu Shiro; von Euler Mikael; Blackedge George
[Molecule based diagnosis]
Gan to kagaku ryoho. Cancer & chemotherapy 2004;31(1):125-33.
2004: Bai Jiao; Kitabatake Mutumi; Toyoizumi Kazuki; Fu Liwei; Zhang Shujun; Dai Jungui; Sakai Junichi; Hirose Katutoshi; Yamori Takao; Tomida Akihiro; Tsuruo Takashi; Ando Masayoshi
Production of biologically active taxoids by a callus culture of Taxus cuspidata.
Journal of natural products 2004;67(1):58-63.
2003: Kato Yukinari; Fujita Naoya; Kunita Akiko; Sato Shigeo; Kaneko Mika; Osawa Motoki; Tsuruo Takashi
Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors.
The Journal of biological chemistry 2003;278(51):51599-605.
2003: Fujita Naoya; Sato Saori; Tsuruo Takashi
Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization.
The Journal of biological chemistry 2003;278(49):49254-60.
2003: Imai Yasuo; Asada Sakiyo; Tsukahara Satomi; Ishikawa Etsuko; Tsuruo Takashi; Sugimoto Yoshikazu
Breast cancer resistance protein exports sulfated estrogens but not free estrogens.
Molecular pharmacology 2003;64(3):610-8.
2003: Haga Naomi; Fujita Naoya; Tsuruo Takashi
Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis.
Oncogene 2003;22(36):5579-85.
2003: Jiang Chen; Koyabu Noriko; Yonemitsu Yoshikazu; Shimazoe Takao; Watanabe Shigenori; Naito Mikihiko; Tsuruo Takashi; Ohtani Hisakazu; Sawada Yasufumi
In vivo delivery of glial cell-derived neurotrophic factor across the blood-brain barrier by gene transfer into brain capillary endothelial cells.
Human gene therapy 2003;14(12):1181-91.
2003: Fujita Naoya; Tsuruo Takashi
Survival-signaling pathway as a promising target for cancer chemotherapy.
Cancer chemotherapy and pharmacology 2003;52 Suppl 1():S24-8.
2003: Sugimoto Yoshikazu; Tsukahara Satomi; Sato Shigeo; Suzuki Mutsumi; Nunoi Hiroyuki; Malech Harry L; Gottesman Michael M; Tsuruo Takashi
Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91.
The journal of gene medicine 2003;5(5):366-76.
2003: Akaza Hideyuki; Fukuoka Masahiro; Ohtsu Atsushi; Usami Michiyuki; Ikeda Tadashi; Aiba Keisuke; Isonishi Seiji; Ohashi Yasuo; Saijo Nagahiro; Sone Saburo; Tsukagoshi Shigeru; Tsuruo Takashi; Kato Masuhiro; Mikami Osamu; Dong Rui-Ping; von Euler Mikael; Blackledge George; Stribling Don
[Globalization of clinical trials]
Gan to kagaku ryoho. Cancer & chemotherapy 2003;30(4):555-65.
2003: Tsuruo Takashi
[Translational research for cancer therapeutics]
Gan to kagaku ryoho. Cancer & chemotherapy 2003;30(4):449-54.
2003: Shimonaka Mika; Katagiri Koko; Nakayama Toshinori; Fujita Naoya; Tsuruo Takashi; Yoshie Osamu; Kinashi Tatsuo
Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow.
The Journal of cell biology 2003;161(2):417-27.
2003: Tsuruo Takashi
Molecular cancer therapeutics: recent progress and targets in drug resistance.
Internal medicine (Tokyo, Japan) 2003;42(3):237-43.
2003: Yasui Wataru; Nishiyama Masahiko; Tsuruo Takashi; Tahara Eiichi
Molecular targeting therapy for cancer: the Twelfth International Symposium of the Hiroshima Cancer Seminar, November 2002.
Cancer science 2003;94(2):221-3.
2003: Yang Liling; Mashima Tetsuo; Sato Shigeo; Mochizuki Mikiko; Sakamoto Hiroshi; Yamori Takao; Oh-Hara Tomoko; Tsuruo Takashi
Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.
Cancer research 2003;63(4):831-7.
2003: Naasani Imad; Oh-Hashi Fujiko; Oh-Hara Tomoko; Feng Wan Yong; Johnston Jeffrey; Chan Kenneth; Tsuruo Takashi
Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo.
Cancer research 2003;63(4):824-30.
2003: Yamaji Ryoichi; Fujita Kayoko; Takahashi Saeko; Yoneda Hiroko; Nagao Kaori; Masuda Wataru; Naito Mikihiko; Tsuruo Takashi; Miyatake Kazutaka; Inui Hiroshi; Nakano Yoshihisa
Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger.
Biochimica et biophysica acta 2003;1593(2-3):269-76.
2003: Tsuruo Takashi; Naito Mikihiko; Tomida Akihiro; Fujita Naoya; Mashima Tetsuo; Sakamoto Hiroshi; Haga Naomi
Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.
Cancer science 2003;94(1):15-21.
2003: Sugimoto Yoshikazu; Tsukahara Satomi; Imai Yasuo; Sugimoto Yoshikazu; Ueda Kazumitsu; Tsuruo Takashi
Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists.
Molecular cancer therapeutics 2003;2(1):105-12.
2002: Tsuruo Takashi
[New approach in drug designing: molecular-targeted drugs]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2002;91(12):3401-7.
2002: Fujii S; Kitayama J; Kaisaki S; Sasaki S; Seto Y; Tominaga O; Tsuno N; Umetani N; Yokota H; Kitamura K; Tsuruo T; Nagawa H
Carcinoembryonic antigen mRNA in abdominal cavity as a useful predictor of peritoneal recurrence of gastric cancer with serosal exposure.
Journal of experimental & clinical cancer research : CR 2002;21(4):547-53.
2002: Rokudai Susumu; Fujita Naoya; Kitahara Osamu; Nakamura Yusuke; Tsuruo Takashi
Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis.
Molecular and cellular biology 2002;22(24):8695-708.
2002: Akaza Hideyuki; Ohashi Yasuo; Shimada Yasuhiro; Ikeda Tadashi; Saijo Nagahiro; Isonishi Seiji; Hirao Yoshihiko; Tsuruo Takashi; Tsukagoshi Shigeru; Sone Saburo; Nakamura Seigo; Kato Masuhiro; Mikami Osamu; von Euler Mikael; Blackledge George; Milsted Bob; Vose Brent
[Post launch studies]
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(11):2037-48.
2002: Horie Koji; Tomida Akihiro; Sugimoto Yoshikazu; Yasugi Toshiharu; Yoshikawa Hiroyuki; Taketani Yuji; Tsuruo Takashi
SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin.
Oncogene 2002;21(52):7913-22.
2002: Sakamoto Hiroshi; Mashima Tetsuo; Yamamoto Kazuo; Tsuruo Takashi
Modulation of heat-shock protein 27 (Hsp27) anti-apoptotic activity by methylglyoxal modification.
The Journal of biological chemistry 2002;277(48):45770-5.
2002: Martin Daniel; Salinas Marta; Fujita Naoya; Tsuruo Takashi; Cuadrado Antonio
Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.
The Journal of biological chemistry 2002;277(45):42943-52.
2002: Sato Saori; Fujita Naoya; Tsuruo Takashi
Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.
The Journal of biological chemistry 2002;277(42):39360-7.
2002: Ogiso Yasunari; Tomida Akihiro; Tsuruo Takashi
Nuclear localization of proteasomes participates in stress-inducible resistance of solid tumor cells to topoisomerase II-directed drugs.
Cancer research 2002;62(17):5008-12.
2002: Kaneta Yasuyuki; Kagami Yoshitoyo; Katagiri Toyomasa; Tsunoda Tatsuhiko; Jin-nai Itsuro; Taguchi Hirokuni; Hirai Hisamaru; Ohnishi Kazunori; Ueda Takanori; Emi Nobuhiko; Tomida Akihiro; Tsuruo Takashi; Nakamura Yusuke; Ohno Ryuzo
Prediction of sensitivity to STI571 among chronic myeloid leukemia patients by genome-wide cDNA microarray analysis.
Japanese journal of cancer research : Gann 2002;93(8):849-56.
2002: Chikatsu Noriko; Takeuchi Yasuhiro; Fukumoto Seiji; Yano Kazuki; Fujita Naoya; Tsuruo Takashi; Fujita Toshiro
Clonal endothelial cells produce humoral factors that inhibit osteoclast-like cell formation in vitro.
Endocrine journal 2002;49(4):439-47.
2002: Yamamoto Chika; Murakami Hideyasu; Koyabu Noriko; Takanaga Hitomi; Matsuo Hirotami; Uchiumi Takeshi; Kuwano Michihiko; Naito Mikihiko; Tsuruo Takashi; Ohtani Hisakazu; Sawada Yasufumi
Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier.
The Journal of pharmacy and pharmacology 2002;54(8):1055-63.
2002: Fujita Naoya; Sato Saori; Katayama Kazuhiro; Tsuruo Takashi
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
The Journal of biological chemistry 2002;277(32):28706-13.
2002: Seimiya Hiroyuki; Oh-hara Tomoko; Suzuki Tsuneji; Naasani Imad; Shimazaki Toshiyuki; Tsuchiya Katsutoshi; Tsuruo Takashi
Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991.
Molecular cancer therapeutics 2002;1(9):657-65.
2002: Hosoya Ken-Ichi; Tomi Masatoshi; Ohtsuki Sumio; Takanaga Hitomi; Saeki Shigeki; Kanai Yoshikatsu; Endou Hitoshi; Naito Mikihiko; Tsuruo Takashi; Terasaki Tetsuya
Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment.
The Journal of pharmacology and experimental therapeutics 2002;302(1):225-31.
2002: Ishida Atsushi; Fujita Naoya; Kitazawa Riko; Tsuruo Takashi
Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone.
The Journal of biological chemistry 2002;277(29):26217-24.
2002: Imai Yasuo; Nakane Minoru; Kage Kumie; Tsukahara Satomi; Ishikawa Etsuko; Tsuruo Takashi; Miki Yoshio; Sugimoto Yoshikazu
C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.
Molecular cancer therapeutics 2002;1(8):611-6.
2002: Jiang Chen; Matsuo Hirotami; Koyabu Noriko; Ohtani Hisakazu; Fujimoto Hidenori; Yonemitsu Yoshikazu; Kaneda Yasufumi; Narro Mikihiko; Tsuruo Takashi; Sawada Yasufumi
Transluminal gene transfer into brain capillary endothelial cells in vivo with HVJ-liposomes.
Journal of drug targeting 2002;10(4):345-52.
2002: Murakami Makoto; Yoshihara Kumiko; Shimbara Satoko; Sawada Masatsugu; Inagaki Naoki; Nagai Hiroichi; Naito Mikihiko; Tsuruo Takashi; Moon Tae Churl; Chang Hyeun Wook; Kudo Ichiro
Group IID heparin-binding secretory phospholipase A(2) is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues.
European journal of biochemistry / FEBS 2002;269(11):2698-707.
2002: Nakanishi Kazuaki; Sakamoto Michiie; Yasuda Jun; Takamura Masaaki; Fujita Naoya; Tsuruo Takashi; Todo Satoru; Hirohashi Setsuo
Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer.
Cancer research 2002;62(10):2971-5.
2002: Fontana Jason; Fulton David; Chen Yan; Fairchild Todd A; McCabe Timothy J; Fujita Naoya; Tsuruo Takashi; Sessa William C
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release.
Circulation research 2002;90(8):866-73.
2002: Hasumi Yoko; Mizukami Hiroaki; Urabe Masashi; Kohno Takahiro; Takeuchi Koichi; Kume Akihiro; Momoeda Mikio; Yoshikawa Hiroyuki; Tsuruo Takashi; Shibuya Masabumi; Taketani Yuji; Ozawa Keiya
Soluble FLT-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer.
Cancer research 2002;62(7):2019-23.
2002: Kimura Yoshimitsu; Aoki Jun; Kohno Masayuki; Ooka Hisayoshi; Tsuruo Takashi; Nakanishi Osamu
P-glycoprotein inhibition by the multidrug resistance-reversing agent MS-209 enhances bioavailability and antitumor efficacy of orally administered paclitaxel.
Cancer chemotherapy and pharmacology 2002;49(4):322-8.
2002: Tatsumi Mitsuaki; Tsuruo Takashi; Nishimura Tsunehiko
Evaluation of MS-209, a novel multidrug-resistance-reversing agent, in tumour-bearing mice by technetium-99m-MIBI imaging.
European journal of nuclear medicine and molecular imaging 2002;29(3):288-94.
2002: Imai Yasuo; Tsukahara Satomi; Ishikawa Etsuko; Tsuruo Takashi; Sugimoto Yoshikazu
Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance.
Japanese journal of cancer research : Gann 2002;93(3):231-5.
2002: Sato Saori; Fujita Naoya; Tsuruo Takashi
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).
Oncogene 2002;21(11):1727-38.
2002: Nakashio Ayako; Fujita Naoya; Tsuruo Takashi
Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway.
International journal of cancer. Journal international du cancer 2002;98(1):36-41.
2002: Ikegawa Tomomi; Ohtani Hisakazu; Koyabu Noriko; Juichi Motoharu; Iwase Yukiko; Ito Chihiro; Furukawa Hiroshi; Naito Mikihiko; Tsuruo Takashi; Sawada Yasufumi
Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.
Cancer letters 2002;177(1):89-93.
2002: Fujita Naoya; Sato Saori; Ishida Atsushi; Tsuruo Takashi
Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.
The Journal of biological chemistry 2002;277(12):10346-53.
2002: Akaza Hideyuki; Aiba Keisuke; Isonishi Seiji; Ikeda Tadashi; Ohashi Yasuo; Kawai Koji; Saijo Nagahiro; Saeki Toshiaki; Sone Saburo; Tsukagoshi Shigeru; Tsuruo Takashi; Boku Narikazu; Kato Masuhiro; Mikami Osamu; Blackledge George; Stribling Don
[Globalization of anti-cancer therapies]
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(2):205-14.
2002: Naito Mikihiko; Matsuba Yasuhiro; Sato Shigeo; Hirata Hiroshi; Tsuruo Takashi
MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):582-8.
2002: Kage Kumie; Tsukahara Satomi; Sugiyama Tomomi; Asada Sakiyo; Ishikawa Etsuko; Tsuruo Takashi; Sugimoto Yoshikazu
Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization.
International journal of cancer. Journal international du cancer 2002;97(5):626-30.
2002: Sawada Masashi; Moriya Setsuko; Saito Seiichi; Shineha Ryuzaburo; Satomi Susumu; Yamori Takao; Tsuruo Takashi; Kannagi Reiji; Miyagi Taeko
Reduced sialidase expression in highly metastatic variants of mouse colon adenocarcinoma 26 and retardation of their metastatic ability by sialidase overexpression.
International journal of cancer. Journal international du cancer 2002;97(2):180-5.
2002: Sunami Eiji; Tsuno Nelson Hirokazu; Kitayama Joji; Saito Shinsuke; Osada Takuya; Yamaguchi Hironori; Tomozawa Shigeru; Tsuruo Takashi; Shibata Yoichi; Nagawa Hirokazu
Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone.
Surgery today 2002;32(4):343-50.
2002: Naasani Imad; Yamori Takao; Tsuruo Takashi
Screening with COMPARE analysis for telomerase inhibitors.
Methods in molecular biology (Clifton, N.J.) 2002;191():197-207.
2001: Akaza H; Saeki T; Kawai K; Aiba K; Isonishi S; Ohashi Y; Sone S; Tamura T; Tsukagoshi S; Tsuruo T; Noguchi S; Miki T; Kato M; Mikami O; Barge A; Blackledge G
[Comparison of management of advanced cancer in various organs]
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(12):1845-55.
2001: Yano HKitayama J; Hatano K; Tsuno N; Osada T; Watanabe T; Tsuruo T; Muto T; Nagawa H
Clustered cancer cells show a distinct adhesion behavior from single cell form under physiological shear conditions.
Journal of experimental & clinical cancer research : CR 2001;20(3):407-12.
2001: Suzuki H; Tomida A; Tsuruo T
Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia.
Oncogene 2001;20(41):5779-88.
2001: Mashima T; Udagawa S; Tsuruo T
Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis.
Journal of cellular physiology 2001;188(3):352-8.
2001: Sakamoto H; Mashima T; Sato S; Hashimoto Y; Yamori T; Tsuruo T
Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2513-8.
2001: Yamane K; Katayama E; Tsuruo T
p53 contains a DNA break-binding motif similar to the functional part of BRCT-related region of Rb.
Oncogene 2001;20(23):2859-67.
2001: Akaza H; Saijo N; Aiba K; Isonishi S; Ohashi Y; Kawai K; Konishi T; Saeki T; Sone S; Tsukagoshi S; Tsuruo T; Noguchi S; Miki T; Mikami O; Smith M; Hoctin-Boes G; Stribling D
[Platinum compounds in cancer therapy--past, present, and future]
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(5):625-35.
2000: Yamane K; Katayama E; Tsuruo T
The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing feature.
Biochemical and biophysical research communications 2000;279(2):678-84.
2000: Dohgu S; Kataoka Y; Ikesue H; Naito M; Tsuruo T; Oishi R; Sawada Y
Involvement of glial cells in cyclosporine-increased permeability of brain endothelial cells.
Cellular and molecular neurobiology 2000;20(6):781-6.
2000: Ikegawa T; Ushigome F; Koyabu N; Morimoto S; Shoyama Y; Naito M; Tsuruo T; Ohtani H; Sawada Y
Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.
Cancer letters 2000;160(1):21-8.
2000: Nakagawa T; Tanaka S; Suzuki H; Takayanagi H; Miyazaki T; Nakamura K; Tsuruo T
Overexpression of the csk gene suppresses tumor metastasis in vivo.
International journal of cancer. Journal international du cancer 2000;88(3):384-91.
2000: Akaza H; Aiba K; Isonishi S; Ogawa O; Shibuya M; Sone S; Tsuruo T; Noguchi S; Hinotsu S; Kono S; Mikami O; Blackledge G; Vose B; Stribling D
[Development of molecular targeting drugs for the treatment of cancer-therapeutic potential and issues to be addressed in global development]
Gan to kagaku ryoho. Cancer & chemotherapy 2000;27(11):1681-93.
2000: Kageyama T; Nakamura M; Matsuo A; Yamasaki Y; Takakura Y; Hashida M; Kanai Y; Naito M; Tsuruo T; Minato N; Shimohama S
The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.
Brain research 2000;879(1-2):115-21.
2000: Nakashio A; Fujita N; Rokudai S; Sato S; Tsuruo T
Prevention of phosphatidylinositol 3'-kinase-Akt survival signaling pathway during topotecan-induced apoptosis.
Cancer research 2000;60(18):5303-9.
2000: Sato S; Fujita N; Tsuruo T
Modulation of Akt kinase activity by binding to Hsp90.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10832-7.
2000: Kosugi K; Sakai J; Zhang S; Watanabe Y; Sasaki H; Suzuki T; Hagiwara H; Hirata N; Hirose K; Ando M; Tomida A; Tsuruo T
Neutral taxoids from Taxus cuspidata as modulators of multidrug-resistant tumor cells.
Phytochemistry 2000;54(8):839-45.
2000: Ishiguro T; Nagawa H; Naito M; Tsuruo T
Inhibitory effect of ATF3 antisense oligonucleotide on ectopic growth of HT29 human colon cancer cells.
Japanese journal of cancer research : Gann 2000;91(8):833-6.
2000: Tomozawa S; Tsuno N H; Sunami E; Hatano K; Kitayama J; Osada T; Saito S; Tsuruo T; Shibata Y; Nagawa H
Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer.
British journal of cancer 2000;83(3):324-8.
2000: Kobayashi J; Shigemori H; Hosoyama H; Chen Z; Akiyama S; Naito M; Tsuruo T
Multidrug resistance reversal activity of taxoids from Taxus cuspidata in KB-C2 and 2780AD cells.
Japanese journal of cancer research : Gann 2000;91(6):638-42.
2000: Seimiya H; Sawada H; Muramatsu Y; Shimizu M; Ohko K; Yamane K; Tsuruo T
Involvement of 14-3-3 proteins in nuclear localization of telomerase.
The EMBO journal 2000;19(11):2652-61.
2000: Yanase K; Sugimoto Y; Tsukahara S; Oh-Hara T; Andoh T; Tsuruo T
Identification and characterization of a deletion mutant of DNA topoisomerase I mRNA in a camptothecin-resistant subline of human colon carcinoma.
Japanese journal of cancer research : Gann 2000;91(5):551-9.
2000: Mitsunaga Y; Takanaga H; Matsuo H; Naito M; Tsuruo T; Ohtani H; Sawada Y
Effect of bioflavonoids on vincristine transport across blood-brain barrier.
European journal of pharmacology 2000;395(3):193-201.
2000: Ogiso Y; Tomida A; Lei S; Omura S; Tsuruo T
Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs.
Cancer research 2000;60(9):2429-34.
2000: Sakamoto H; Mashima T; Kizaki A; Dan S; Hashimoto Y; Naito M; Tsuruo T
Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis.
Blood 2000;95(10):3214-8.
2000: Yamane K; Katayama E; Sugasawa K; Tsuruo T
Retinoblastoma susceptibility protein, Rb, possesses multiple BRCT-Ws, BRCA1 carboxyl-terminus-related W regions with DNA break-binding activity.
Oncogene 2000;19(16):1982-91.
2000: Takenoue T; Nagawa H; Matsuda K; Fujii S; Nita M E; Hatano K; Kitayama J; Tsuruo T; Muto T
Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method.
Annals of surgical oncology 2000;7(3):193-8.
2000: Takenoue T; Kitayama J; Takei Y; Umetani N; Matsuda K; Nita M E; Hatano K; Tsuruo T; Nagawa H
Characterization of dihydropyrimidine dehydrogenase on immunohistochemistry in colon carcinoma, and correlation between immunohistochemical score and protein level or messenger RNA expression.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(3):273-9.
2000: Torii S; Yamane K; Mashima T; Haga N; Yamamoto K; Fox J W; Naito M; Tsuruo T
Molecular cloning and functional analysis of apoxin I, a snake venom-derived apoptosis-inducing factor with L-amino acid oxidase activity.
Biochemistry 2000;39(12):3197-205.
2000: Rokudai S; Fujita N; Hashimoto Y; Tsuruo T
Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis.
Journal of cellular physiology 2000;182(2):290-6.
2000: Matsuo H; Okamura T; Chen J; Takanaga H; Ohtani H; Kaneda Y; Naito M; Tsuruo T; Sawada Y
Efficient introduction of macromolecules and oligonucleotides into brain capillary endothelial cells using HVJ-liposomes.
Journal of drug targeting 2000;8(4):207-16.
2000: Sunami E; Tsuno N; Osada T; Saito S; Kitayama J; Tomozawa S; Tsuruo T; Shibata Y; Muto T; Nagawa H
MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer.
The oncologist 2000;5(2):108-14.
1999: Tomozawa S; Nagawa H; Tsuno N; Hatano K; Osada T; Kitayama J; Sunami E; Nita M E; Ishihara S; Yano H; Tsuruo T; Shibata Y; Muto T
Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
British journal of cancer 1999;81(8):1274-9.
1999: Zhang Y; Fujita N; Tsuruo T
p21Waf1/Cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line.
International journal of cancer. Journal international du cancer 1999;83(6):790-7.
1999: Chen Z; Naito M; Hori S; Mashima T; Yamori T; Tsuruo T
A human IAP-family gene, apollon, expressed in human brain cancer cells.
Biochemical and biophysical research communications 1999;264(3):847-54.
1999: Akaza H; Tsuruo T; Tsukamoto T; Noguchi S; Moriwaki H; Isonishi S; Masuda N; Hinotsu S; Nash A F; von Euler M; Wildin J; Stribling D
[Early detection and prevention of cancers in various therapeutic areas. Discussion]
Gan to kagaku ryoho. Cancer & chemotherapy 1999;26(11):1585-97.
1999: Yamane K; Tsuruo T
Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA.
Oncogene 1999;18(37):5194-203.
1999: Naasani I; Seimiya H; Yamori T; Tsuruo T
FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis.
Cancer research 1999;59(16):4004-11.
1999: Sawada N; Takanaga H; Matsuo H; Naito M; Tsuruo T; Sawada Y
Choline uptake by mouse brain capillary endothelial cells in culture.
The Journal of pharmacy and pharmacology 1999;51(7):847-52.
1999: Nita M E; Nagawa H; Tominaga O; Tsuno N; Hatano K; Kitayama J; Tsuruo T; Domene C E; Muto T
p21Waf1/Cip1 expression is a prognostic marker in curatively resected esophageal squamous cell carcinoma, but not p27Kip1, p53, or Rb.
Annals of surgical oncology 1999;6(5):481-8.
1999: Seimiya H; Tanji M; Oh-hara T; Tomida A; Naasani I; Tsuruo T
Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells.
Biochemical and biophysical research communications 1999;260(2):365-70.
1999: Hirotani M; Zhang Y; Fujita N; Naito M; Tsuruo T
NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis.
The Journal of biological chemistry 1999;274(29):20415-20.
1999: Kim H D; Tomida A; Ogiso Y; Tsuruo T
Glucose-regulated stresses cause degradation of DNA topoisomerase IIalpha by inducing nuclear proteasome during G1 cell cycle arrest in cancer cells.
Journal of cellular physiology 1999;180(1):97-104.
1999: Mizukami S; Kikuchi K; Higuchi T; Urano Y; Mashima T; Tsuruo T; Nagano T
Imaging of caspase-3 activation in HeLa cells stimulated with etoposide using a novel fluorescent probe.
FEBS letters 1999;453(3):356-60.
1999: Kochi S; Takanaga H; Matsuo H; Naito M; Tsuruo T; Sawada Y
Effect of cyclosporin A or tacrolimus on the function of blood-brain barrier cells.
European journal of pharmacology 1999;372(3):287-95.
1999: Ogiso Y; Tomida A; Kim H D; Tsuruo T
Glucose starvation and hypoxia induce nuclear accumulation of proteasome in cancer cells.
Biochemical and biophysical research communications 1999;258(2):448-52.
1999: Kita H; Matsuo H; Takanaga H; Kawakami J; Yamamoto K; Iga T; Naito M; Tsuruo T; Asanuma A; Yanagisawa K; Sawada Y
In vivo and in vitro toxicodynamic analyses of new quinolone-and nonsteroidal anti-inflammatory drug-induced effects on the central nervous system.
Antimicrobial agents and chemotherapy 1999;43(5):1091-7.
1999: Nakagawa T; Fujita N; Oh-Hara T; Kurokawa T; Nakamura K; Tsuruo T
Interleukin-1 alpha induced cyclooxygenase-2 expression in bone-derived endothelial cells.
Journal of cellular physiology 1999;179(2):226-32.
1999: Mashima T; Naito M; Tsuruo T
Caspase-mediated cleavage of cytoskeletal actin plays a positive role in the process of morphological apoptosis.
Oncogene 1999;18(15):2423-30.
1999: Matsuzaki J; Yamamoto C; Miyama T; Takanaga H; Matsuo H; Ishizuka H; Kawahara Y; Kuwano M; Naito M; Tsuruo T; Sawada Y
Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier.
Biopharmaceutics & drug disposition 1999;20(2):85-90.
1999: Yanase K; Sugimoto Y; Andoh T; Tsuruo T
Retroviral expression of a mutant (Gly-533) human DNA topoisomerase I cDNA confers a dominant form of camptothecin resistance.
International journal of cancer. Journal international du cancer 1999;81(1):134-40.
1999: Hosoyama H; Shigemori H; Tomida A; Tsuruo T; Kobayashi J
Modulation of multidrug resistance in tumor cells by taxinine derivatives.
Bioorganic & medicinal chemistry letters 1999;9(3):389-94.
1999: Dan S; Naito M; Seimiya H; Kizaki A; Mashima T; Tsuruo T
Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells.
Oncogene 1999;18(6):1277-83.
1999: Zhang Y; Fujita N; Tsuruo T
Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis.
Oncogene 1999;18(5):1131-8.
1999: Seto Y; Nagawa H; Mori M; Tsuruo T; Muto T
Effect of 5-fluorouracil on gastrointestinal carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
Digestive diseases and sciences 1999;44(1):75-8.
1999: Chen Z; Seimiya H; Naito M; Mashima T; Kizaki A; Dan S; Imaizumi M; Ichijo H; Miyazono K; Tsuruo T
ASK1 mediates apoptotic cell death induced by genotoxic stress.
Oncogene 1999;18(1):173-80.
1999: Kage K; Fujita N; Oh-hara T; Ogata E; Fujita T; Tsuruo T
Basic fibroblast growth factor induces cyclooxygenase-2 expression in endothelial cells derived from bone.
Biochemical and biophysical research communications 1999;254(1):259-63.
1999: Homma M; Suzuki H; Kusuhara H; Naito M; Tsuruo T; Sugiyama Y
High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).
The Journal of pharmacology and experimental therapeutics 1999;288(1):198-203.
1999: Yamada M; Tomida A; Yun J; Cai B; Yoshikawa H; Taketani Y; Tsuruo T
Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress.
Cancer chemotherapy and pharmacology 1999;44(1):59-64.
1998: Fujii S; Tominaga O; Nagawa H; Tsuno N; Nita M E; Tsuruo T; Muto T
Quantitative analysis of the cyclin expression in human esophageal cancer cell lines.
Journal of experimental & clinical cancer research : CR 1998;17(4):491-6.
1998: Nita M E; Tominaga O; Nagawa H; Tsuruo T; Muto T
Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer.
Hepato-gastroenterology 1998;45(24):2117-22.
1998: Suzuki H; Tomida A; Tsuruo T
A novel mutant from apoptosis-resistant colon cancer HT-29 cells showing hyper-apoptotic response to hypoxia, low glucose and cisplatin.
Japanese journal of cancer research : Gann 1998;89(11):1169-78.
1998: Cai B; Tomida A; Mikami K; Nagata K; Tsuruo T
Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions.
Journal of cellular physiology 1998;177(2):282-8.
1998: Iwata M; Nunoi H; Matsuda I; Kanegasaki S; Tsuruo T; Sugimoto Y
Drug-selected complete restoration of superoxide generation in Epstein-Barr virus-transformed B cells from p47phox-deficient chronic granulomatous disease patients by using a bicistronic retrovirus vector encoding a human multi-drug resistance gene (MDR1) and the p47phox gene.
Human genetics 1998;103(4):419-23.
1998: Nita M E; Nagawa H; Tominaga O; Tsuno N; Fujii S; Sasaki S; Fu C G; Takenoue T; Tsuruo T; Muto T
5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins.
British journal of cancer 1998;78(8):986-92.
1998: Mashima T; Seimiya H; Chen Z; Kataoka S; Tsuruo T
Apoptosis resistance in tumor cells.
Cytotechnology 1998;27(1-3):293-308.
1998: Dong J; Naito M; Dan S; Tsuruo T
Establishment of a mutant from human monocytic leukaemia U937 that exhibits a genetically dominant resistance to TNF alpha-induced apoptosis.
Apoptosis : an international journal on programmed cell death 1998;3(4):245-54.
1998: Mikami K; Naito M; Ishiguro T; Yano H; Tomida A; Yamada T; Tanaka N; Shirakusa T; Tsuruo T
Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase.
Japanese journal of cancer research : Gann 1998;89(9):910-5.
1998: Takanaga H; Murakami H; Koyabu N; Matsuo H; Naito M; Tsuruo T; Sawada Y
Efflux transport of tolbutamide across the blood-brain barrier.
The Journal of pharmacy and pharmacology 1998;50(9):1027-33.
1998: Fujita N; Nagahashi A; Nagashima K; Rokudai S; Tsuruo T
Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases.
Oncogene 1998;17(10):1295-304.
1998: Dan S; Naito M; Tsuruo T
Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR - ABL tyrosine kinase, CGP 57148.
Cell death and differentiation 1998;5(8):710-5.
1998: Naasani I; Seimiya H; Tsuruo T
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
Biochemical and biophysical research communications 1998;249(2):391-6.
1998: Seimiya H; Tsuruo T
Functional involvement of PTP-U2L in apoptosis subsequent to terminal differentiation of monoblastoid leukemia cells.
The Journal of biological chemistry 1998;273(33):21187-93.
1998: Miyama T; Takanaga H; Matsuo H; Yamano K; Yamamoto K; Iga T; Naito M; Tsuruo T; Ishizuka H; Kawahara Y; Sawada Y
P-glycoprotein-mediated transport of itraconazole across the blood-brain barrier.
Antimicrobial agents and chemotherapy 1998;42(7):1738-44.
1998: Kobayashi J; Hosoyama H; Wang X X; Shigemori H; Sudo Y; Tsuruo T
Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.
Bioorganic & medicinal chemistry letters 1998;8(12):1555-8.
1998: Suzuki M; Sugimoto Y; Tsuruo T
Efficient protection of cells from the genotoxicity of nitrosoureas by the retrovirus-mediated transfer of human O6-methylguanine-DNA methyltransferase using bicistronic vectors with human multidrug resistance gene 1.
Mutation research 1998;401(1-2):133-41.
1998: Kusuhara H; Suzuki H; Naito M; Tsuruo T; Sugiyama Y
Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1260-5.
1998: Morinaga Y; Fujita N; Ohishi K; Zhang Y; Tsuruo T
Suppression of interleukin-11-mediated bone resorption by cyclooxygenases inhibitors.
Journal of cellular physiology 1998;175(3):247-54.
1998: Fujita N; Tsuruo T
Involvement of Bcl-2 cleavage in the acceleration of VP-16-induced U937 cell apoptosis.
Biochemical and biophysical research communications 1998;246(2):484-8.
1998: Haga N; Naito M; Seimiya H; Tomida A; Dong J; Tsuruo T
2-Deoxyglucose inhibits chemotherapeutic drug-induced apoptosis in human monocytic leukemia U937 cells with inhibition of c-Jun N-terminal kinase 1/stress-activated protein kinase activation.
International journal of cancer. Journal international du cancer 1998;76(1):86-90.
1998: Zhang Y; Fujita N; Oh-hara T; Morinaga Y; Nakagawa T; Yamada M; Tsuruo T
Production of interleukin-11 in bone-derived endothelial cells and its role in the formation of osteolytic bone metastasis.
Oncogene 1998;16(6):693-703.
1998: Dong J; Naito M; Mashima T; Jang W H; Tsuruo T
Genetically recessive mutant of human monocytic leukemia U937 resistant to tumor necrosis factor-alpha-induced apoptosis.
Journal of cellular physiology 1998;174(2):179-85.
1998: Fu C G; Tominaga O; Nagawa H; Nita M E; Masaki T; Ishimaru G; Higuchi Y; Tsuruo T; Muto T
Role of p53 and p21/WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients.
Diseases of the colon and rectum 1998;41(1):68-74.
1998: Kato Y; Hori S; Fujita N; Tsuruo T
A novel anti-platelet monoclonal antibody induces mouse platelet aggregation through an Fc receptor-independent mechanism.
Biochemical and biophysical research communications 1998;242(2):250-5.
1998: Sugimoto Y; Gottesman M M; Pastan I; Tsuruo T
Construction of MDR1 vectors for gene therapy.
Methods in enzymology 1998;292():523-37.
1998: Naito M; Tsuruo T
Monoclonal antibodies to P-glycoprotein: preparation and applications to basic and clinical research.
Methods in enzymology 1998;292():258-65.
1997: Yamane K; Kawabata M; Tsuruo T
A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator.
European journal of biochemistry / FEBS 1997;250(3):794-9.
1997: Naito M; Shiina K; Mashima T; Nagashima K; Tsuruo T
Induction of in vitro nuclear apoptosis activity coincides with the production of 50 kDa cytosolic protein.
Cell death and differentiation 1997;4(7):617-22.
1997: Mano Y; Suzuki H; Terasaki T; Iwahashi T; Ono K; Naito M; Tsuruo T; Sugiyama Y
Kinetic analysis of the disposition of MRK16, an anti-P-glycoprotein monoclonal antibody, in tumors: comparison between in vitro and in vivo disposition.
The Journal of pharmacology and experimental therapeutics 1997;283(1):391-401.
1997: Tominaga O; Nita M E; Nagawa H; Fujii S; Tsuruo T; Muto T
Expressions of cell cycle regulators in human colorectal cancer cell lines.
Japanese journal of cancer research : Gann 1997;88(9):855-60.
1997: Mikami K; Shirakusa T; Tsuruo T
[DT-diaphorase]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(11):1606-10.
1997: Mashima T; Tsuruo T
[ICE family proteins]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(11):1454-9.
1997: Ohta T; Kinoshita T; Naito M; Nozaki T; Masutani M; Tsuruo T; Miyajima A
Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells.
The Journal of biological chemistry 1997;272(37):23111-6.
1997: Fukuda S; Kuroki T; Kohsaki H; Hayashi S; Ozaki K; Yamori T; Tsuruo T; Nakamori S; Imaoka S; Nakamura Y
Isolation of a novel gene showing reduced expression in metastatic colorectal carcinoma cell lines and carcinomas.
Japanese journal of cancer research : Gann 1997;88(8):725-31.
1997: Dong J; Naito M; Tsuruo T
c-Myc plays a role in cellular susceptibility to death receptor-mediated and chemotherapy-induced apoptosis in human monocytic leukemia U937 cells.
Oncogene 1997;15(6):639-47.
1997: Kato Y; Fujita N; Yano H; Tsuruo T
Suppression of experimental lung colonization of mouse colon adenocarcinoma 26 in vivo by an anti-idiotype monoclonal antibody recognizing a platelet surface molecule.
Cancer research 1997;57(14):3040-5.
1997: Suzuki M; Sugimoto Y; Tsukahara S; Okochi E; Gottesman M M; Tsuruo T
Retroviral coexpression of two different types of drug resistance genes to protect normal cells from combination chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(6):947-54.
1997: Fujita N; Kodama N; Kato Y; Lee S H; Tsuruo T
Aggregation of Thy-1 glycoprotein induces thymocyte apoptosis through activation of CPP32-like proteases.
Experimental cell research 1997;232(2):400-6.
1997: Morinaga Y; Fujita N; Ohishi K; Tsuruo T
Stimulation of interleukin-11 production from osteoblast-like cells by transforming growth factor-beta and tumor cell factors.
International journal of cancer. Journal international du cancer 1997;71(3):422-8.
1997: Sugimoto Y; Tsuruo T
In vivo drug-selectable markers in gene therapy.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11 Suppl 3():552-6.
1997: Watanabe T; Naito M; Kokubu N; Tsuruo T
Regression of established tumors expressing P-glycoprotein by combinations of adriamycin, cyclosporin derivatives, and MRK-16 antibodies.
Journal of the National Cancer Institute 1997;89(7):512-8.
1997: Torii S; Naito M; Tsuruo T
Apoxin I, a novel apoptosis-inducing factor with L-amino acid oxidase activity purified from Western diamondback rattlesnake venom.
The Journal of biological chemistry 1997;272(14):9539-42.
1997: Mashima T; Naito M; Noguchi K; Miller D K; Nicholson D W; Tsuruo T
Actin cleavage by CPP-32/apopain during the development of apoptosis.
Oncogene 1997;14(9):1007-12.
1997: Naito M; Nagashima K; Mashima T; Tsuruo T
Phosphatidylserine externalization is a downstream event of interleukin-1 beta-converting enzyme family protease activation during apoptosis.
Blood 1997;89(6):2060-6.
1997: Seimiya H; Mashima T; Toho M; Tsuruo T
c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis.
The Journal of biological chemistry 1997;272(7):4631-6.
1997: Mashima T; Tsuruo T
[Involvement of ICE/CED 3 family proteases in antitumor agent-induced apoptosis]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(2):211-5.
1997: Sugimoto Y; Sato S; Tsukahara S; Suzuki M; Okochi E; Gottesman M M; Pastan I; Tsuruo T
Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.
Cancer gene therapy 1997;4(1):51-8.
1997: Lee S H; Fujita N; Tsuruo T
Activation of a CPP32-like protease during L1210 cell apoptosis induced by thiol deprivation.
Apoptosis : an international journal on programmed cell death 1997;2(1):77-83.
1997: Naito M; Tsuruo T
New multidrug-resistance-reversing drugs, MS-209 and SDZ PSC 833.
Cancer chemotherapy and pharmacology 1997;40 Suppl():S20-4.
1997: Yamada M; Tomida A; Yoshikawa H; Taketani Y; Tsuruo T
Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines.
Cancer chemotherapy and pharmacology 1997;40(1):31-7.
1996: Tomida A; Suzuki H; Kim H D; Tsuruo T
Glucose-regulated stresses cause decreased expression of cyclin D1 and hypophosphorylation of retinoblastoma protein in human cancer cells.
Oncogene 1996;13(12):2699-705.
1996: Lee S H; Fujita N; Mashima T; Tsuruo T
Interleukin-7 inhibits apoptosis of mouse malignant T-lymphoma cells by both suppressing the CPP32-like protease activation and inducing the Bcl-2 expression.
Oncogene 1996;13(10):2131-9.
1996: Chen Z; Naito M; Mashima T; Tsuruo T
Activation of actin-cleavable interleukin 1beta-converting enzyme (ICE) family protease CPP-32 during chemotherapeutic agent-induced apoptosis in ovarian carcinoma cells.
Cancer research 1996;56(22):5224-9.
1996: Tomida A; Yun J; Tsuruo T
Glucose-regulated stresses induce resistance to camptothecin in human cancer cells.
International journal of cancer. Journal international du cancer 1996;68(3):391-6.
1996: Yano S; Nishioka Y; Izumi K; Tsuruo T; Tanaka T; Miyasaka M; Sone S
Novel metastasis model of human lung cancer in SCID mice depleted of NK cells.
International journal of cancer. Journal international du cancer 1996;67(2):211-7.
1996: Naito M; Watanabe T; Tsuge H; Koyama T; Oh-hara T; Tsuruo T
Potentiation of the reversal activity of SDZ PSC833 on multi-drug resistance by an anti-P-glycoprotein monoclonal antibody MRK-16.
International journal of cancer. Journal international du cancer 1996;67(3):435-40.
1996: Noguchi K; Naito M; Oshimura M; Mashima T; Fujita N; Yonehara S; Tsuruo T
Chromosome 22 complements apoptosis in Fas-and TNF-resistant mutant UK110 cells.
Oncogene 1996;13(1):39-46.
1996: Mikami K; Naito M; Tomida A; Yamada M; Sirakusa T; Tsuruo T
DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.
Cancer research 1996;56(12):2823-6.
1996: Fujita N; Kato Y; Naito M; Tsuruo T
A novel anti-Thy-1 (CD90) monoclonal antibody induces apoptosis in mouse malignant T-lymphoma cells in spite of inducing bcl-2 expression.
International journal of cancer. Journal international du cancer 1996;66(4):544-50.
1996: Yamada M; Tomida A; Yoshikawa H; Taketani Y; Tsuruo T
Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(2):427-32.
1996: Ishiguro T; Nakajima M; Naito M; Muto T; Tsuruo T
Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials.
Cancer research 1996;56(4):875-9.
1996: Watanabe T; Naito M; Oh-hara T; Itoh Y; Cohen D; Tsuruo T
Modulation of multidrug resistance by SDZ PSC 833 in leukemic and solid-tumor-bearing mouse models.
Japanese journal of cancer research : Gann 1996;87(2):184-93.
1996: Fujii H; Nakajima M; Aoyagi T; Tsuruo T
Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors.
Biological & pharmaceutical bulletin 1996;19(1):6-10.
1996: Kamishohara M; Kawai H; Sakai T; Uchida T; Tsuruo T; Otake N
Inhibitory effect of a spicamycin derivative, KRN5500, on the growth of hepatic metastasis of human colon cancer-producing tissue polypeptide antigen.
Cancer chemotherapy and pharmacology 1996;38(6):495-8.
1995: Sakai T; Kawai H; Kamishohara M; Odagawa A; Suzuki A; Uchida T; Kawasaki T; Tsuruo T; Otake N
Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives.
The Journal of antibiotics 1995;48(12):1467-80.
1995: Mashima T; Naito M; Fujita N; Noguchi K; Tsuruo T
Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis.
Biochemical and biophysical research communications 1995;217(3):1185-92.
1995: Yusa K; Tamura J; Waki A; Tsuruo T
Activation of silent MDR1 genes in revertant cells by fusion with multidrug-resistant cells.
Biochimica et biophysica acta 1995;1269(3):260-6.
1995: Okochi E; Iwahashi T; Ariyoshi K; Watabe H; Tsuruo T; Ono K
Establishment and evaluation of MRK16-magnetic cell sorting assays for detecting low expression of multidrug resistance P-glycoprotein using human leukemia cell lines and peripheral blood cells from healthy donors.
Journal of immunological methods 1995;187(1):127-37.
1995: Seimiya H; Sawabe T; Toho M; Tsuruo T
Phorbol ester-resistant monoblastoid leukemia cells with a functional mitogen-activated protein kinase cascade but without responsive protein tyrosine phosphatases.
Oncogene 1995;11(10):2047-54.
1995: Noguchi K; Naito M; Kataoka S; Yonehara S; Tsuruo T
A recessive mutant of the U937 cell line acquired resistance to anti-Fas and anti-p55 tumor necrosis factor receptor antibody-induced apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(10):1271-7.
1995: Watanabe T; Suzuki H; Sawada Y; Naito M; Tsuruo T; Inaba M; Hanano M; Sugiyama Y
Induction of hepatic P-glycoprotein enhances biliary excretion of vincristine in rats.
Journal of hepatology 1995;23(4):440-8.
1995: Fujii H; Nakajima M; Saiki I; Yoneda J; Azuma I; Tsuruo T
Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13.
Clinical & experimental metastasis 1995;13(5):337-44.
1995: Yamaki H; Nakajima M; Seimiya H; Saya H; Sugita M; Tsuruo T
Inhibition of the association with nuclear matrix of pRB, p70 and p40 proteins along with the specific suppression of c-MYC expression by geldanamycin, an inhibitor of Src tyrosine kinase.
The Journal of antibiotics 1995;48(9):1021-6.
1995: Nabioullin R; Yanagawa H; Haku T; Hiramatsu K; Yano S; Hanibuchi M; Pai K; Tsuruo T; Sone S
Influence of systemic chemotherapy on anti-P-glycoprotein antibody-dependent cell-mediated cytotoxicity in patients with small cell lung cancer.
Japanese journal of clinical oncology 1995;25(4):124-30.
1995: Lee S H; Fujita N; Imai K; Tsuruo T
Cysteine produced from lymph node stromal cells suppresses apoptosis of mouse malignant T-lymphoma cells.
Biochemical and biophysical research communications 1995;213(3):837-44.
1995: Ohishi K; Fujita N; Morinaga Y; Tsuruo T
H-31 human breast cancer cells stimulate type I collagenase production in osteoblast-like cells and induce bone resorption.
Clinical & experimental metastasis 1995;13(4):287-95.
1995: Sakai T; Kawai H; Kamishohara M; Odagawa A; Suzuki A; Uchida T; Kawasaki T; Tsuruo T; Otake N
Synthesis and antitumor activities of glycine-exchanged analogs of spicamycin.
The Journal of antibiotics 1995;48(6):504-8.
1995: Seimiya H; Sawabe T; Inazawa J; Tsuruo T
Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents.
Oncogene 1995;10(9):1731-8.
1995: Hanaoka K; Fujita N; Lee S H; Seimiya H; Naito M; Tsuruo T
Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells.
Cancer research 1995;55(10):2186-90.
1995: Fujita N; Naito M; Lee S H; Hanaoka K; Tsuruo T
Apoptosis inhibition by anti-M(r) 23,000 (Thy-1) monoclonal antibodies without inducing bcl-2 expression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(4):355-62.
1995: Mashima T; Naito M; Kataoka S; Kawai H; Tsuruo T
Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells.
Biochemical and biophysical research communications 1995;209(3):907-15.
1995: Tsuruo T
[Development of drugs to overcome drug resistance--basic approaches]
Gan to kagaku ryoho. Cancer & chemotherapy 1995;22(3):365-70.
1995: Toyoshima M; Nakajima M; Yamori T; Tsuruo T
Purification and characterization of the platelet-aggregating sialoglycoprotein gp44 expressed by highly metastatic variant cells of mouse colon adenocarcinoma 26.
Cancer research 1995;55(4):767-73.
1995: Tomida A; Naito M; Tsuruo T
Acute induction of adriamycin-resistance in human colon carcinoma HT-29 cells exposed to a sublethal dose of adriamycin.
Japanese journal of cancer research : Gann 1995;86(2):224-32.
1995: Noguchi K; Nakajima M; Naito M; Tsuruo T
Inhibition by differentiation-inducing agents of wild-type p53-dependent apoptosis in HL-60 cells.
Japanese journal of cancer research : Gann 1995;86(2):217-23.
1995: Yusa K; Oh-hara T; Tsuruo T
Induction of resistance to 1-beta-D-arabinofuranosylcytosine in human H9 cell line by simian immunodeficiency virus.
Biochemical and biophysical research communications 1995;206(2):486-91.
1995: Yun J; Tomida A; Nagata K; Tsuruo T
Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II.
Oncology research 1995;7(12):583-90.
1995: Dong J; Naito M; Tatsuta T; Seimiya H; Johdo O; Tsuruo T
Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines.
Oncology research 1995;7(5):245-52.
1995: Sato W; Fukazawa N; Nakanishi O; Baba M; Suzuki T; Yano O; Naito M; Tsuruo T
Reversal of multidrug resistance by a novel quinoline derivative, MS-209.
Cancer chemotherapy and pharmacology 1995;35(4):271-7.
1995: Baba M; Nakanishi O; Sato W; Saito A; Miyama Y; Yano O; Shimada S; Fukazawa N; Naito M; Tsuruo T
Relationship between multidrug resistant gene expression and multidrug resistant-reversing effect of MS-209 in various tumor cells.
Cancer chemotherapy and pharmacology 1995;36(5):361-7.
1995: Naito M; Tsuruo T
Reconstitution of purified P-glycoprotein into liposomes.
Journal of cancer research and clinical oncology 1995;121(9-10):582-6.
1994: Tsuruo T; Inaba M; Tashiro T; Yamori T; Ohnishi Y; Ashizawa T; Sakai T; Kobayashi S; Gomi K
Evaluation of antitumor activity of navelbine (vinorelbine ditartrate) against human breast carcinoma xenografts based on its pharmacokinetics in nude mice.
Anti-cancer drugs 1994;5(6):634-40.
1994: Kamishohara M; Kawai H; Odagawa A; Isoe T; Mochizuki J; Uchida T; Hayakawa Y; Seto H; Tsuruo T; Otake N
Antitumor activity of SPM VIII, a derivative of the nucleoside antibiotic spicamycin, against human tumor xenografts.
The Journal of antibiotics 1994;47(11):1305-11.
1994: Kataoka S; Naito M; Tomida A; Tsuruo T
Resistance to antitumor agent-induced apoptosis in a mutant of human myeloid leukemia U937 cells.
Experimental cell research 1994;215(1):199-205.
1994: Tatsuta T; Naito M; Mikami K; Tsuruo T
Enhanced expression by the brain matrix of P-glycoprotein in brain capillary endothelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(10):1145-52.
1994: Yusa K; Oh-hara T; Tsukahara S; Baba K; Taniguchi M; Kozawa M; Takeuchi S; Hara H; Tsuruo T
Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by daphnodorins.
Antiviral research 1994;25(1):57-66.
1994: Shirai A; Naito M; Tatsuta T; Dong J; Hanaoka K; Mikami K; Oh-hara T; Tsuruo T
Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein.
Biochimica et biophysica acta 1994;1222(3):400-4.
1994: Tsuruo T
[MDR reversing drugs for clinical development]
Gan to kagaku ryoho. Cancer & chemotherapy 1994;21(7):962-7.
1994: Lee J H; Naito M; Tsuruo T
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Cancer research 1994;54(9):2398-403.
1994: Naito M; Tsuruo T
[Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16, and their synergistic modulation of multidrug resistance]
Gan to kagaku ryoho. Cancer & chemotherapy 1994;21(3):395-402.
1994: Yano S; Sone S; Nishioka Y; Naito M; Tsuruo T; Ogura T
Cyclosporin A enhances susceptibility of multi-drug resistant human cancer cells to anti-P-glycoprotein antibody-dependent cytotoxicity of monocytes, but not of lymphocytes.
Japanese journal of cancer research : Gann 1994;85(2):194-203.
1994: Tsuruo T; Fujita N; Kataoka S
Apoptosis of T lymphoma cells and its inhibition by monoclonal antibodies against cell surface adhesion molecules.
Princess Takamatsu symposia 1994;24():91-8.
1994: Kamishohara M; Kawai H; Sakai T; Isoe T; Hasegawa K; Mochizuki J; Uchida T; Kataoka S; Yamaki H; Tsuruo T
Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells.
Oncology research 1994;6(8):383-90.
1993: Nakajima M; Welch D R; Wynn D M; Tsuruo T; Nicolson G L
Serum and plasma M(r) 92,000 progelatinase levels correlate with spontaneous metastasis of rat 13762NF mammary adenocarcinoma.
Cancer research 1993;53(23):5802-7.
1993: Seimiya H; Tsuruo T
Differential expression of protein tyrosine phosphatase genes during phorbol ester-induced differentiation of human leukemia U937 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(12):1033-9.
1993: Iwahashi T; Okochi E; Ariyoshi K; Watabe H; Amann E; Mori S; Tsuruo T; Ono K
Specific targeting and killing activities of anti-P-glycoprotein monoclonal antibody MRK16 directed against intrinsically multidrug-resistant human colorectal carcinoma cell lines in the nude mouse model.
Cancer research 1993;53(22):5475-82.
1993: Fujita N; Kataoka S; Naito M; Heike Y; Boku N; Nakajima M; Tsuruo T
Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell surface adhesion molecules.
Cancer research 1993;53(20):5022-7.
1993: Kamishohara M; Kawai H; Odagawa A; Isoe T; Mochizuki J; Uchida T; Hayakawa Y; Seto H; Tsuruo T; Otake N
Structure-antitumor activity relationship of semi-synthetic spicamycin analogues.
The Journal of antibiotics 1993;46(9):1439-46.
1993: Kataoka S; Naito M; Fujita N; Ishii H; Ishii S; Yamori T; Nakajima M; Tsuruo T
Control of apoptosis and growth of malignant T lymphoma cells by lymph node stromal cells.
Experimental cell research 1993;207(2):271-6.
1993: Ishii S; Naito M; Tsuruo T
Expression behavior of 85-kDa membrane protein in adriamycin-resistant tumor cells and the inhibition of human tumor growth in athymic mice by MRK-20 monoclonal antibody against the protein.
Japanese journal of cancer research : Gann 1993;84(7):776-82.
1993: Tatsuta T; Tsuruo T
[Functional involvement of P-glycoprotein in blood-brain barrier]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(9):1501-9.
1993: Heike Y; Sone S; Yano S; Seimiya H; Tsuruo T; Ogura T
M-CSF gene transduction in multidrug-resistant human cancer cells to enhance anti-P-glycoprotein antibody-dependent macrophage-mediated cytotoxicity.
International journal of cancer. Journal international du cancer 1993;54(5):851-7.
1993: Sugimoto Y; Hamada H; Tsukahara S; Noguchi K; Yamaguchi K; Sato M; Tsuruo T
Molecular cloning and characterization of the complementary DNA for the M(r) 85,000 protein overexpressed in adriamycin-resistant human tumor cells.
Cancer research 1993;53(11):2538-43.
1993: Naito M; Tsuge H; Kuroko C; Tomida A; Tsuruo T
Enhancement of reversing effect of cyclosporin A on vincristine resistance by anti-P-glycoprotein monoclonal antibody MRK-16.
Japanese journal of cancer research : Gann 1993;84(5):489-92.
1993: Noguchi K; Naito M; Tezuka K; Ishii S; Seimiya H; Sugimoto Y; Amann E; Tsuruo T
cDNA expression cloning of the 85-kDa protein overexpressed in adriamycin-resistant cells.
Biochemical and biophysical research communications 1993;192(1):88-95.
1993: Tsuruo T; Oh-Hara T; Sudo Y; Naito M
Antitumor activity of idarubicin, a derivative of daunorubicin, against drug sensitive and resistant P388 leukemia.
Anticancer research 1993;13(2):357-61.
1993: Takatori T; Ogura M; Tsuruo T
Purification and characterization of NF-R2 that regulates the expression of the human multidrug resistance (MDR1) gene.
Japanese journal of cancer research : Gann 1993;84(3):298-303.
1993: Kataoka S; Fujita N; Tsuruo T
[Apoptosis, adhesion and growth factor of malignant T lymphoma cells]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(2):134-40.
1993: Fujita N; Kataoka S; Tsuruo T
[Lymphatic metastasis and cell adhesion, growth and growth inhibition]
Gan to kagaku ryoho. Cancer & chemotherapy 1993;20(3):399-404.
1993: Nakajima M; Gohji K; Fabra A; Fidler I A; Tsuruo T
[Regulation of tumor metastasis and extracellular matrix degradative enzyme production by microenvironments]
Gan to kagaku ryoho. Cancer & chemotherapy 1993;20(3):380-6.
1993: Naito M; Tsuge H; Kuroko C; Koyama T; Tomida A; Tatsuta T; Heike Y; Tsuruo T
Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance.
Journal of the National Cancer Institute 1993;85(4):311-6.
1993: Ishii S; Satoh Y; Tsuruo T
Antitumor activity and cytotoxicity of a new ankinomycin derivative, 3'-,11-dibutyryl ankinomycin.
Cancer chemotherapy and pharmacology 1993;32(3):173-8.
1993: Lee J H; Naito M; Nakajima M; Tsuruo T
Isolation and characterization of a mitomycin C-resistant variant of human colon carcinoma HT-29 cells.
Cancer chemotherapy and pharmacology 1993;33(3):215-20.
1992: Tatsuta T; Naito M; Oh-hara T; Sugawara I; Tsuruo T
Functional involvement of P-glycoprotein in blood-brain barrier.
The Journal of biological chemistry 1992;267(28):20383-91.
1992: Isoe T; Naito M; Shirai A; Hirai R; Tsuruo T
Inhibition of different steps of the ubiquitin system by cisplatin and aclarubicin.
Biochimica et biophysica acta 1992;1117(2):131-5.
1992: Yusa K; Oh-hara T; Tsukahara S; Tsuruo T
Human immunodeficiency virus type 1 induces 1-beta-D-arabinofuranosylcytosine resistance in human H9 cell line.
The Journal of biological chemistry 1992;267(24):16848-50.
1992: Nishioka Y; Sone S; Heike Y; Hamada H; Ariyoshi K; Tsuruo T; Ogura T
Effector cell analysis of human multidrug-resistant cell killing by mouse-human chimeric antibody against P-glycoprotein.
Japanese journal of cancer research : Gann 1992;83(6):644-9.
1992: Katagiri N; Nomura M; Sato H; Kaneko C; Yusa K; Tsuruo T
Synthesis and anti-HIV activity of 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine.
Journal of medicinal chemistry 1992;35(10):1882-6.
1992: Yamaki H; Yamaguchi M; Tsuruo T; Yamaguchi H
Mechanism of action of an antifungal antibiotic, RI-331, (S) 2-amino-4-oxo-5-hydroxypentanoic acid; kinetics of inactivation of homoserine dehydrogenase from Saccharomyces cerevisiae.
The Journal of antibiotics 1992;45(5):750-5.
1992: Ariyoshi K; Hamada H; Naito M; Heike Y; Seimiya H; Maezawa K; Tsuruo T
Mouse-human chimeric antibody MH171 against the multidrug transporter P-glycoprotein.
Japanese journal of cancer research : Gann 1992;83(5):515-21.
1992: Naito M; Tsuruo T
Functionally active homodimer of P-glycoprotein in multidrug-resistant tumor cells.
Biochemical and biophysical research communications 1992;185(1):284-90.
1992: Katagiri N; Shiraishi T; Sato H; Toyota A; Kaneko C; Yusa K; Oh-hara T; Tsuruo T
Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer.
Biochemical and biophysical research communications 1992;184(1):154-9.
1992: Heike Y; Okumura K; Tsuruo T
Augmentation by bispecific F(ab')2 reactive with P-glycoprotein and CD3 of cytotoxicity of human effector cells on P-glycoprotein positive human renal cancer cells.
Japanese journal of cancer research : Gann 1992;83(4):366-72.
1992: Ishii S; Naito M; Masuda M; Tsuruo T
Expression of 85-kDa protein of adriamycin-resistant tumor cells during hematopoietic differentiation of THP-1 and HEL cells.
Japanese journal of cancer research : Gann 1992;83(1):107-12.
1992: Naito M; Oh-hara T; Yamazaki A; Danki T; Tsuruo T
Reversal of multidrug resistance by an immunosuppressive agent FK-506.
Cancer chemotherapy and pharmacology 1992;29(3):195-200.
1991: Yamori T; Iizuka Y; Takayama Y; Nishiya S; Iwashita S; Yamazaki A; Takatori T; Tsuruo T
Insulin-like growth factor I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metastatic mouse colon carcinoma 26 NL-17 cells.
Cancer research 1991;51(21):5859-65.
1991: Ogura M; Takatori T; Sugimoto Y; Tsuruo T
Identification and characterization of three DNA-binding proteins on the promoter of the human MDR1 gene in drug-sensitive and -resistant cells.
Japanese journal of cancer research : Gann 1991;82(10):1151-9.
1991: Isoe T; Naito M; Hirai R; Tsuruo T
Inhibition of ubiquitin-ATP-dependent proteolysis and ubiquitination by cisplatin.
Anticancer research 1991;11(5):1905-9.
1991: Iwahashi T; Okochi E; Ono K; Sugawara I; Tsuruo T; Mori S
Establishment of multidrug resistant human colorectal carcinoma HCT-15 cell lines and their properties.
Anticancer research 1991;11(3):1309-12.
1991: Sato W; Fukazawa N; Suzuki T; Yusa K; Tsuruo T
Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073.
Cancer research 1991;51(9):2420-4.
1991: Sugimoto Y; Watanabe M; Oh-hara T; Sato S; Isoe T; Tsuruo T
Suppression of experimental lung colonization of a metastatic variant of murine colon adenocarcinoma 26 by a monoclonal antibody 8F11 inhibiting tumor cell-induced platelet aggregation.
Cancer research 1991;51(3):921-5.
1991: Tomioka K; Ishiguro T; Mizuguchi H; Komeshima N; Koga K; Tsukagoshi S; Tsuruo T; Tashiro T; Tanida S; Kishi T
Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues.
Journal of medicinal chemistry 1991;34(1):54-7.
1991: Watanabe M; Komeshima N; Naito M; Isoe T; Otake N; Tsuruo T
Cellular pharmacology of MX2, a new morpholino anthracycline, in human pleiotropic drug-resistant cells.
Cancer research 1991;51(1):157-61.
1990: Sugimoto Y; Tsukahara S; Oh-hara T; Liu L F; Tsuruo T
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.
Cancer research 1990;50(24):7962-5.
1990: Sato W; Yusa K; Naito M; Tsuruo T
Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells.
Biochemical and biophysical research communications 1990;173(3):1252-7.
1990: Tsuruo T
[Cancer metastasis and platelet aggregation]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(15):2818-24.
1990: Sugimoto Y; Tsukahara S; Oh-hara T; Isoe T; Tsuruo T
Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.
Cancer research 1990;50(21):6925-30.
1990: Heike Y; Hamada H; Inamura N; Sone S; Ogura T; Tsuruo T
Monoclonal anti-P-glycoprotein antibody-dependent killing of multidrug-resistant tumor cells by human mononuclear cells.
Japanese journal of cancer research : Gann 1990;81(11):1155-61.
1990: Watanabe M; Sugimoto Y; Tsuruo T
Expression of a Mr 41,000 glycoprotein associated with thrombin-independent platelet aggregation in high metastatic variants of murine B16 melanoma.
Cancer research 1990;50(20):6657-62.
1990: Sugawara I; Hamada H; Tsuruo T; Mori S
Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.
Japanese journal of cancer research : Gann 1990;81(8):727-30.
1990: Sugimoto Y; Oh-Hara T; Heike Y; Watanabe M; Nakatsuru Y; Ishikawa T; Tsuruo T
Establishment of highly metastatic variants of murine colon adenocarcinoma 26 under serum-free conditions.
International journal of cancer. Journal international du cancer 1990;46(1):118-24.
1990: Yusa K; Oh-hara T; Yamazaki A; Tsukahara S; Satoh W; Tsuruo T
Cross-resistance to anti-HIV nucleoside analogs in multidrug-resistant human cells.
Biochemical and biophysical research communications 1990;169(3):986-90.
1990: Sugimoto Y; Okochi E; Hamada H; Oh-hara T; Tsuruo T
Detection of 300-kilodalton membrane protein in adriamycin-resistant human tumor cells by a monoclonal antibody MRK18.
Biochemical and biophysical research communications 1990;169(2):686-91.
1990: Hamada H; Miura K; Ariyoshi K; Heike Y; Sato S; Kameyama K; Kurosawa Y; Tsuruo T
Mouse-human chimeric antibody against the multidrug transporter P-glycoprotein.
Cancer research 1990;50(11):3167-71.
1990: Tsuruo T; Naito M; Takamori R; Tsukahara S; Yamabe-Mitsuhashi J; Yamazaki A; Oh-hara T; Sudo Y; Nakaike S; Yamagishi T
A benzophenazine derivative, N-beta-dimethylaminoethyl 9-carboxy-5-hydroxy-10-methoxy-benzo[a]phenazine-6-carboxamide, as a new antitumor agent against multidrug-resistant and sensitive tumors.
Cancer chemotherapy and pharmacology 1990;26(2):83-7.
1990: Tsuruo T; Sudo Y; Asami N; Inaba M; Morimoto M
Antitumor activity of a derivative of mitomycin, 7-N-[2-[[2-(gamma-L-glutamylamino)ethyl]dithio]ethyl]mitomycin C (KW-2149), against murine and human tumors and a mitomycin C-resistant tumor in vitro and in vivo.
Cancer chemotherapy and pharmacology 1990;27(2):89-93.
1990: Tsuruo T
Multidrug resistance: a transport system of antitumor agents and xenobiotics.
Princess Takamatsu symposia 1990;21():241-51.
1989: Sugawara I; Hamada H; Nakahama M; Okamoto S; Tsuruo T; Mori S
Further characterization of the human adrenal-derived P-glycoprotein recognized by monoclonal antibody MRK 16 reacting with only human P-glycoprotein.
Japanese journal of cancer research : Gann 1989;80(12):1199-205.
1989: Tsuruo T; Yusa K; Sudo Y; Takamori R; Sugimoto Y
A fluorine-containing anthracycline (ME2303) as a new antitumor agent against murine and human tumors and their multidrug-resistant sublines.
Cancer research 1989;49(20):5537-42.
1989: Sugimoto Y; Asami N; Tsuruo T
Expression of P-glycoprotein mRNA in human gastric tumors.
Japanese journal of cancer research : Gann 1989;80(10):993-9.
1989: Sugawara I; Kodo H; Ohkochi E; Hamada H; Tsuruo T; Mori S
High-level expression of MRK 16 and MRK 20 murine monoclonal antibody-define proteins (170,000-180,000 P-glycoprotein and 85,000 protein) in leukaemias and malignant lymphomas.
British journal of cancer 1989;60(4):538-41.
1989: Komeshima N; Kawai H; Nakajima S; Watanabe M; Tsuruo T; Takeuchi T; Otake N
Role of DNA-binding in the cytotoxicity of an anthracycline, R20X2 and its morpholino analog, MX2.
The Journal of antibiotics 1989;42(9):1424-9.
1989: Yusa K; Tsuruo T
Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.
Cancer research 1989;49(18):5002-6.
1989: Tsuruo T; Hamada H; Sato S; Heike Y
Inhibition of multidrug-resistant human tumor growth in athymic mice by anti-P-glycoprotein monoclonal antibodies.
Japanese journal of cancer research : Gann 1989;80(7):627-31.
1989: Tsuruo T; Sato S; Yusa K
Antitumor activity of ME2303, a fluorine-containing anthracycline, against human tumors implanted in nude mice.
Japanese journal of cancer research : Gann 1989;80(7):686-9.
1989: Sugawara I; Mizumoto K; Ohkochi E; Hamada H; Tsuruo T; Mori S
Immunocytochemical identification and localization of the Mr 22,000 calcium-binding protein (sorcin) in an adriamycin-resistant myelogenous leukemia cell line.
Japanese journal of cancer research : Gann 1989;80(5):469-74.
1989: Shinoda H; Inaba M; Tsuruo T
In vivo circumvention of vincristine resistance in mice with P388 leukemia using a novel compound, AHC-52.
Cancer research 1989;49(7):1722-6.
1989: Naito M; Tsuruo T
Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.
Cancer research 1989;49(6):1452-5.
1989: Naito M; Yusa K; Tsuruo T
Steroid hormones inhibit binding of Vinca alkaloid to multidrug resistance related P-glycoprotein.
Biochemical and biophysical research communications 1989;158(3):1066-71.
1989: Tsuruo T; Watanabe M; Oh-hara T
Stimulation of the growth of metastatic clones of mouse colon adenocarcinoma 26 in vitro by platelet-derived growth factor.
Japanese journal of cancer research : Gann 1989;80(2):136-40.
1989: Koenuma M; Yamori T; Tsuruo T
Insulin and insulin-like growth factor 1 stimulate proliferation of metastatic variants of colon carcinoma 26.
Japanese journal of cancer research : Gann 1989;80(1):51-8.
1988: Watanabe M; Komeshima N; Nakajima S; Tsuruo T
MX2, a morpholino anthracycline, as a new antitumor agent against drug-sensitive and multidrug-resistant human and murine tumor cells.
Cancer research 1988;48(23):6653-7.
1988: Hamada H; Okochi E; Watanabe M; Oh-hara T; Sugimoto Y; Kawabata H; Tsuruo T
Mr 85,000 membrane protein specifically expressed in adriamycin-resistant human tumor cells.
Cancer research 1988;48(24 Pt 1):7082-7.
1988: Watanabe M; Okochi E; Sugimoto Y; Tsuruo T
Identification of a platelet-aggregating factor of murine colon adenocarcinoma 26: Mr 44,000 membrane protein as determined by monoclonal antibodies.
Cancer research 1988;48(22):6411-6.
1988: Sugawara I; Ohkochi E; Hamada H; Tsuruo T; Mori S
Cellular and tissue distribution of MRK20 murine monoclonal antibody-defined 85-kDa protein in adriamycin-resistant cancer cell lines.
Japanese journal of cancer research : Gann 1988;79(10):1101-10.
1988: Hamada H; Tsuruo T
Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.
Cancer research 1988;48(17):4926-32.
1988: Naito M; Hamada H; Tsuruo T
ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.
The Journal of biological chemistry 1988;263(24):11887-91.
1988: Sugawara I; Nakahama M; Hamada H; Tsuruo T; Mori S
Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr 170,000-180,000 P-glycoprotein.
Cancer research 1988;48(16):4611-4.
1988: Hamada H; Okochi E; Oh-hara T; Tsuruo T
Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies.
Cancer research 1988;48(11):3173-8.
1988: Komeshima N; Tsuruo T; Umezawa H
Antitumor activity of new morpholino anthracyclines.
The Journal of antibiotics 1988;41(4):548-53.
1988: Sugawara I; Kataoka I; Morishita Y; Hamada H; Tsuruo T; Itoyama S; Mori S
Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.
Cancer research 1988;48(7):1926-9.
1988: Tsuruo T
Mechanisms of multidrug resistance and implications for therapy.
Japanese journal of cancer research : Gann 1988;79(3):285-96.
1988: Hamada H; Tsuruo T
Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.
The Journal of biological chemistry 1988;263(3):1454-8.
1988: Yusa K; Hamada H; Tsuruo T
Comparison of glutathione S-transferase activity between drug-resistant and -sensitive human tumor cells: is glutathione S-transferase associated with multidrug resistance?
Cancer chemotherapy and pharmacology 1988;22(1):17-20.
1988: Tsuruo T; Matsuzaki T; Matsushita M; Saito H; Yokokura T
Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo.
Cancer chemotherapy and pharmacology 1988;21(1):71-4.
1987: Tsuruo T; Sugimoto Y; Hamada H; Roninson I; Okumura M; Adachi K; Morishima Y; Ohno R
Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.
Japanese journal of cancer research : Gann 1987;78(12):1415-9.

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