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Takashi Tsuruo

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Naomi Haga; Sakae Saito; Yoshinori Tsukumo; Junko Sakurai; Aki Furuno; Takashi Tsuruo; Akihiro Tomida
Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions.
Tomokazu Ohishi; Toru Hirota; Takashi Tsuruo; Hiroyuki Seimiya
TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.
Mi-Hwa Kim; Han-Joo Maeng; Kyung-Ha Yu; Kyeong-Ryoon Lee; Takashi Tsuruo; Dae-Duk Kim; Chang-Koo Shim; Suk-Jae Chung
Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain.

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2010: Naomi Haga; Sakae Saito; Yoshinori Tsukumo; Junko Sakurai; Aki Furuno; Takashi Tsuruo; Akihiro Tomida
Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions.
Cancer science 2010;101(5):1125-32.
2010: Tomokazu Ohishi; Toru Hirota; Takashi Tsuruo; Hiroyuki Seimiya
TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.
Cancer research 2010;70(5):2041-52.
2010: Mi-Hwa Kim; Han-Joo Maeng; Kyung-Ha Yu; Kyeong-Ryoon Lee; Takashi Tsuruo; Dae-Duk Kim; Chang-Koo Shim; Suk-Jae Chung
Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain.
Journal of pharmaceutical sciences 2010;99(3):1548-66.
2010: Ryohei Katayama; Toshiyasu Ishioka; Shinji Takada; Ritsuko Takada; Naoya Fujita; Takashi Tsuruo; Mikihiko Naito
Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L.
Journal of cell science 2010;123(Pt 1):23-8.
2009: Tomiteru Togano; Masataka Sasaki; Mariko Watanabe; Makoto Nakashima; Takashi Tsuruo; Kazuo Umezawa; Masaaki Higashihara; Toshiki Watanabe; Ryouichi Horie
Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.
Biochemical and biophysical research communications 2009;390(1):60-4.
2009: Ramona Schulz; Tanja Vogel; Tetsuo Mashima; Takashi Tsuruo; Kerstin Krieglstein
Involvement of Fractin in TGF-beta-induced apoptosis in oligodendroglial progenitor cells.
Glia 2009;57(15):1619-29.
2009: Ryohei Katayama; Sumie Koike; Shigeo Sato; Yoshikazu Sugimoto; Takashi Tsuruo; Naoya Fujita
Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export.
Cancer science 2009;100(11):2060-8.
2009: Yoshinori Tsukumo; Satomi Tsukahara; Sakae Saito; Takashi Tsuruo; Akihiro Tomida
A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site.
The Journal of biological chemistry 2009;284(40):27500-10.
2009: Tetsuo Mashima; Shigeo Sato; Sachiko Okabe; Satoshi Miyata; Masaaki Matsuura; Yoshikazu Sugimoto; Takashi Tsuruo; Hiroyuki Seimiya
Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide.
Cancer science 2009;100(8):1556-62.
2009: Marie-Josée Demers; Sonya Thibodeau; Dominique Noël; Naoya Fujita; Takashi Tsuruo; Rémy Gauthier; Mélina Arguin; Pierre H Vachon
Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1.
Journal of cellular biochemistry 2009;107(4):639-54.
2009: Jin Miyawaki; Sachiko Matsumura; Ryota Yuge; Tatsuya Murakami; Shigeo Sato; Akihiro Tomida; Takashi Tsuruo; Toshinari Ichihashi; Takako Fujinami; Hiroshi Irie; Kunihiro Tsuchida; Sumio Iijima; Kiyotaka Shiba; Masako Yudasaka
Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd2O3 labels.
ACS nano 2009;3(6):1399-406.
2009: Sakae Saito; Aki Furuno; Junko Sakurai; Asami Sakamoto; Hae-Ryong Park; Kazuo Shin-Ya; Takashi Tsuruo; Akihiro Tomida
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.
Cancer research 2009;69(10):4225-34.
2009: T Mashima; Hiroyuki Seimiya; Takashi Tsuruo
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy.
British journal of cancer 2009;100(9):1369-72.
2009: Hiroshi Tanaka; Yutaka Hoshikawa; Tomoko Oh-hara; Sumie Koike; Mikihiko Naito; Tetsuo Noda; Hiroyuki Arai; Takashi Tsuruo; Naoya Fujita
PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via nuclear factor-kappaB activation.
Molecular cancer research : MCR 2009;7(4):557-69.
2009: Sachiko Matsumura; Shigeo Sato; Masako Yudasaka; Akihiro Tomida; Takashi Tsuruo; Sumio Iijima; Kiyotaka Shiba
Prevention of carbon nanohorn agglomeration using a conjugate composed of comb-shaped polyethylene glycol and a peptide aptamer.
Molecular pharmaceutics 2009;6(2):441-7.
2009: Junichi Matsuo; Yoshinori Tsukumo; Junko Sakurai; Satomi Tsukahara; Hae-Ryong Park; Kazuo Shin-Ya; Toshiki Watanabe; Takashi Tsuruo; Akihiro Tomida
Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin.
Cancer science 2009;100(2):327-33.
2009: T Mashima; S Sato; Y Sugimoto; Takashi Tsuruo; Hiroyuki Seimiya
Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.
Oncogene 2009;28(1):9-19.
2008: Takashi Tsuruo; Gozoh Tsujimoto; Hiroshi Yamamoto
[Introduction to the symposium "Bio-informatics for Pharmaceutical Sciences and Pharmacy Education". Foreword].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008;128(11):1517.
2008: Tae Nakasaki; Toshiyuki Tanaka; Shinichi Okudaira; Michi Hirosawa; Eiji Umemoto; Kazuhiro Otani; Soojung Jin; Zhongbin Bai; Haruko Hayasaka; Yoshinori Fukui; Katsuyuki Aozasa; Naoya Fujita; Takashi Tsuruo; Keiichi Ozono; Junken Aoki; Masayuki Miyasaka
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions.
The American journal of pathology 2008;173(5):1566-76.
2008: Minoru Isomura; Natsuo Oya; Seiji Tachiiri; Yuko Kaneyasu; Yasumasa Nishimura; Tetsuo Akimoto; Masato Hareyama; Tadasi Sugita; Norio Mitsuhashi; Takashi Yamashita; Masahiko Aoki; Heitetsu Sai; Yutaka Hirokawa; Koh-Ichi Sakata; Kumiko Karasawa; Akihiro Tomida; Takashi Tsuruo; Yoshio Miki; Tetsuo Noda; Masahiro Hiraoka
IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6683-9.
2008: Akito Nakamura; Mikihiko Naito; Takashi Tsuruo; Naoya Fujita
Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling.
Molecular and cellular biology 2008;28(19):5996-6009.
2008: Atsuo Kurata; Ryohei Katayama; Toshiki Watanabe; Takashi Tsuruo; Naoya Fujita
TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
Cancer science 2008;99(9):1827-34.
2008: Youya Nakazawa; Shigeo Sato; Mikihiko Naito; Yukinari Kato; Kazuhiko Mishima; Hiroyuki Arai; Takashi Tsuruo; Naoya Fujita
Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.
Blood 2008;112(5):1730-9.
2008: Takashi Tsuruo
[Pharmacogenomics: challenges in promoting its clinical usage].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2008;132(1):31-8.
2008: Daisuke Morishita; Ryohei Katayama; Kazuhisa Sekimizu; Takashi Tsuruo; Naoya Fujita
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
Cancer research 2008;68(13):5076-85.
2008: Keiko Sekine; Kohei Takubo; Ryo Kikuchi; Michie Nishimoto; Masayuki Kitagawa; Fuminori Abe; Kiyohiro Nishikawa; Takashi Tsuruo; Mikihiko Naito
Small molecules destabilize cIAP1 by activating auto-ubiquitylation.
The Journal of biological chemistry 2008;283(14):8961-8.
2008: Véronique Bouchard; Charlène Harnois; Marie-Josée Demers; Sonya Thibodeau; Vincent Laquerre; Rémy Gauthier; Anne Vézina; Dominique Noël; Naoya Fujita; Takashi Tsuruo; Mélina Arguin; Pierre H Vachon
B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms.
Apoptosis : an international journal on programmed cell death 2008;13(4):531-42.
2008: Yukiko Muramatsu; Hidetoshi Tahara; Taeko Ono; Takashi Tsuruo; Hiroyuki Seimiya
Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation.
Experimental cell research 2008;314(5):1115-24.
2008: Hideyuki Akaza; Koji Kawai; Takashi Tsuruo; Shigeru Tsukagoshi; Keisuke Aiba; Yasuhiro Shimada; Yoshihiro Kakeji; Hideki Ishikawa; Tadashi Ikeda; Seigo Nakamura; Tomohide Tamura; Nobuyuki Yamamoto; Seiji Isonishi; Shiro Hinotsu; Masaru Hirose; Jun Katsura
[Future directions of anticancer drug development in Japan].
Gan to kagaku ryoho. Cancer & chemotherapy 2008;35(2):351-60.
2008: Takashi Tsuruo; Naoya Fujita
Platelet aggregation in the formation of tumor metastasis.
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2008;84(6):189-98.
2008: Liyan Wang; Liming Bai; Takashi Nagasawa; Toshiaki Hasegawa; Xiaoyang Yang; Jun-ichi Sakai; Yuhua Bai; Takao Kataoka; Seiko Oka; Katsutoshi Hirose; Akihiro Tomida; Takashi Tsuruo; Masayoshi Ando
Bioactive triterpene saponins from the roots of Phytolacca americana.
Journal of natural products 2008;71(1):35-40.
2007: Lin Huang; Miki Shitashige; Reiko Satow; Kazufumi Honda; Masaya Ono; Jisoo Yun; Akihiro Tomida; Takashi Tsuruo; Setsuo Hirohashi; Tesshi Yamada
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
Gastroenterology 2007;133(5):1569-78.
2007: Shinya Dohgu; Tsuyoshi Nishioku; Noriko Sumi; Fuyuko Takata; Shinsuke Nakagawa; Mikihiko Naito; Takashi Tsuruo; Atsushi Yamauchi; Hideki Shuto; Yasufumi Kataoka
Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro.
Cellular and molecular neurobiology 2007;27(7):889-99.
2007: Emi Tokuda; Naoya Fujita; Tomoko Oh-hara; Shigeo Sato; Atsuo Kurata; Ryohei Katayama; Toshiki Itoh; Tadaomi Takenawa; Kohei Miyazono; Takashi Tsuruo
Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.
Cancer research 2007;67(20):9666-76.
2007: Yoshinori Tsukumo; Akihiro Tomida; Osamu Kitahara; Yusuke Nakamura; Shinichi Asada; Kazutoshi Mori; Takashi Tsuruo
Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation.
The Journal of biological chemistry 2007;282(40):29264-72.
2007: Shunji Takahashi; Keisuke Aiba; Yoshinori Ito; Kiyohiko Hatake; Minoru Nakane; Takayuki Kobayashi; Sayuri Minowa; Harumi Shibata; Junko Mitsuhashi; Satomi Tsukahara; Etsuko Ishikawa; Rieko Suzuki; Takashi Tsuruo; Yoshikazu Sugimoto
Pilot study of MDR1 gene transfer into hematopoietic stem cells and chemoprotection in metastatic breast cancer patients.
Cancer science 2007;98(10):1609-16.
2007: Kazuhiro Ichikawa; Emiko Sakabe; Ken-Ichiro Kuninobu; Takao Yamori; Takashi Tsuruo; Takashi Yao; Masazumi Tsuneyoshi; Hideo Utsumi
Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad.
Antioxidants & redox signaling 2007;9(10):1699-707.
2007: Hisakazu Ohtani; Tomomi Ikegawa; Youko Honda; Noriko Kohyama; Satoshi Morimoto; Yukihiro Shoyama; Motoharu Juichi; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada
Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells.
Pharmaceutical research 2007;24(10):1936-43.
2007: Kazuhiro Ishizu; Naohide Sunose; Kanami Yamazaki; Takashi Tsuruo; Sotaro Sadahiro; Hiroyasu Makuuchi; Takao Yamori
Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.
Biological & pharmaceutical bulletin 2007;30(9):1779-83.
2007: Véronique Bouchard; Marie-Josée Demers; Sonya Thibodeau; Vincent Laquerre; Naoya Fujita; Takashi Tsuruo; Jean-François Beaulieu; Rémy Gauthier; Anne Vézina; Lisabeth Villeneuve; Pierre H Vachon
Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways.
Journal of cellular physiology 2007;212(3):717-28.
2007: Hitoshi Zembutsu; Masamitsu Yanada; Asahi Hishida; Toyomasa Katagiri; Takashi Tsuruo; Isamu Sugiura; Jin Takeuchi; Noriko Usui; Tomoki Naoe; Yusuke Nakamura; Ryuzo Ohno
Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy.
International journal of oncology 2007;31(2):313-22.
2007: Ming Zhao; Liming Bai; Liyan Wang; Asami Toki; Toshiaki Hasegawa; Midori Kikuchi; Mariko Abe; Jun-ichi Sakai; Ryo Hasegawa; Yuhua Bai; Tomokazu Mitsui; Hirotsugu Ogura; Takao Kataoka; Seiko Oka; Hiroko Tsushima; Miwa Kiuchi; Katutoshi Hirose; Akihiro Tomida; Takashi Tsuruo; Masayoshi Ando
Bioactive cardenolides from the stems and twigs of Nerium oleander.
Journal of natural products 2007;70(7):1098-103.
2007: Toshiaki Hasegawa; Jiao Bai; Jungui Dai; Liming Bai; Jun-ichi Sakai; Shigenori Nishizawa; Yuhua Bai; Midori Kikuchi; Mariko Abe; Takao Yamori; Akihiro Tomida; Takashi Tsuruo; Katsutoshi Hirose; Masayoshi Ando
Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
Bioorganic & medicinal chemistry letters 2007;17(13):3722-8.
2007: Margit Rosner; Angelika Freilinger; Michaela Hanneder; Naoya Fujita; Gert Lubec; Takashi Tsuruo; Markus Hengstschläger
p27Kip1 localization depends on the tumor suppressor protein tuberin.
Human molecular genetics 2007;16(13):1541-56.
2007: Toshiyasu Ishioka; Ryohei Katayama; Ryo Kikuchi; Michie Nishimoto; Shinji Takada; Ritsuko Takada; Shu-ichi Matsuzawa; John C Reed; Takashi Tsuruo; Mikihiko Naito
Impairment of the ubiquitin-proteasome system by cellular FLIP.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(6):735-44.
2007: Na Li; Jian-Lin Wu; Toshiaki Hasegawa; Jun-ichi Sakai; Li-ming Bai; Li-yan Wang; Saori Kakuta; Yumiko Furuya; Hirotsugu Ogura; Takao Kataoka; Akihiro Tomida; Takashi Tsuruo; Masayoshi Ando
Bioactive polyketides from Peperomia duclouxii.
Journal of natural products 2007;70(6):998-1001.
2007: Yukiko Muramatsu; Tomokazu Ohishi; Michiko Sakamoto; Takashi Tsuruo; Hiroyuki Seimiya
Cross-species difference in telomeric function of tankyrase 1.
Cancer science 2007;98(6):850-7.
2007: Atsushi Yamauchi; Shinya Dohgu; Tsuyoshi Nishioku; Hideki Shuto; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada; Yasufumi Kataoka
An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function.
Cellular and molecular neurobiology 2007;27(3):263-70.
2007: Katsumi Doh-ura; Kazuhiko Tamura; Yoshiharu Karube; Mikihiko Naito; Takashi Tsuruo; Yasufumi Kataoka
Chelating compound, chrysoidine, is more effective in both antiprion activity and brain endothelial permeability than quinacrine.
Cellular and molecular neurobiology 2007;27(3):303-16.
2007: Fuyuko Takata; Shinya Dohgu; Atsushi Yamauchi; Noriko Sumi; Shinsuke Nakagawa; Mikihiko Naito; Takashi Tsuruo; Hideki Shuto; Yasufumi Kataoka
Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier.
Cellular and molecular neurobiology 2007;27(3):317-28.
2007: Akiko Kunita; Takeshi Kashima; Yasuyuki Morishita; Masashi Fukayama; Yukinari Kato; Takashi Tsuruo; Naoya Fujita
The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis.
The American journal of pathology 2007;170(4):1337-47.
2007: Na Li; Jian-Lin Wu; Toshiaki Hasegawa; Jun-ichi Sakai; Li-Ming Bai; Li-Yan Wang; Saori Kakuta; Yumiko Furuya; Hirotsugu Ogura; Takao Kataoka; Akihiro Tomida; Takashi Tsuruo; Masayoshi Ando
Bioactive lignans from Peperomia duclouxii.
Journal of natural products 2007;70(4):544-8.
2007: Tsuyoshi Nishioku; Fuyuko Takata; Atsushi Yamauchi; Noriko Sumi; Ikumi Yamamoto; Akiko Fujino; Mikihiko Naito; Takashi Tsuruo; Hideki Shuto; Yasufumi Kataoka
Protective action of indapamide, a thiazide-like diuretic, on ischemia-induced injury and barrier dysfunction in mouse brain microvascular endothelial cells.
Journal of pharmacological sciences 2007;103(3):323-7.
2007: Toshiaki Hasegawa; Jao Bai; Shujun Zhang; Jinlan Wang; Junichi Matsubara; Junichi Kawakami; Akihiro Tomida; Takashi Tsuruo; Katsutoshi Hirose; Jun-ichi Sakai; Midori Kikuchi; Mariko Abe; Masayoshi Ando
Structure-activity relationships of some taxoids as multidrug resistance modulator.
Bioorganic & medicinal chemistry letters 2007;17(4):1122-6.
2007: Toshiaki Saeki; Tadashi Nomizu; Masakazu Toi; Yoshinori Ito; Shinzaburo Noguchi; Tadashi Kobayashi; Taro Asaga; Hironobu Minami; Naohito Yamamoto; Kenjiro Aogi; Tadashi Ikeda; Yasuo Ohashi; Wakao Sato; Takashi Tsuruo
Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracil for patients with advanced or recurrent breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(4):411-7.
2007: Naoko Kamo; Kentaro Yasuchika; Hideaki Fujii; Toshitaka Hoppo; Takafumi Machimoto; Takamichi Ishii; Naoya Fujita; Takashi Tsuruo; Jun K Yamashita; Hajime Kubo; Iwao Ikai
Two populations of Thy1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(2):G526-34.
2007: Tomokazu Ohishi; Takashi Tsuruo; Hiroyuki Seimiya
Evaluation of tankyrase inhibition in whole cells.
Methods in molecular biology (Clifton, N.J.) 2007;405():133-46.
2007: Takashi Tsuruo
The centennial of Cancer Science.
Cancer science 2007;98(1):1-4; discussion 5.
2006: Tomoya Kono; Hajime Kubo; Chikashi Shimazu; Yoshihide Ueda; Meiko Takahashi; Kentoku Yanagi; Naoya Fujita; Takashi Tsuruo; Hiromi Wada; Jun K Yamashita
Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(9):2070-6.
2006: Kazuhiko Mishima; Yukinari Kato; Mika K Kaneko; Youya Nakazawa; Akiko Kunita; Naoya Fujita; Takashi Tsuruo; Ryo Nishikawa; Takanori Hirose; Masao Matsutani
Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma.
Acta neuropathologica 2006;111(6):563-8.
2006: Hidetoshi Tahara; K Shin-Ya; H Seimiya; H Yamada; Takashi Tsuruo; Toshinori Ide
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.
Oncogene 2006;25(13):1955-66.
2006: Jungui Dai; Jiao Bai; Toshiaki Hasegawa; Shigenori Nishizawa; Jun-ichi Sakai; Seiko Oka; Miwa Kiuchi; Katutoshi Hirose; Akihiro Tomida; Takashi Tsuruo; Minjie Li; Masayoshi Ando
A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent.
Chemical & pharmaceutical bulletin 2006;54(3):306-9.
2006: Kohei Nozawa; Masashi Tsuda; Haruaki Ishiyama; Takuma Sasaki; Takashi Tsuruo; Jun'ichi Kobayashi
Absolute stereochemistry and antitumor activity of iejimalides.
Bioorganic & medicinal chemistry 2006;14(4):1063-7.
2006: Na Li; Jian-Lin Wu; Toshiaki Hasegawa; Jun-ichi Sakai; Li-yan Wang; Saori Kakuta; Yumiko Furuya; Akihiro Tomida; Takashi Tsuruo; Masayoshi Ando
Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii.
Journal of natural products 2006;69(2):234-9.
2005: Hiroshi Tanaka; Naoya Fujita; Takashi Tsuruo
3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.
The Journal of biological chemistry 2005;280(49):40965-73.
2005: Tetsuo Mashima; Takashi Tsuruo
Defects of the apoptotic pathway as therapeutic target against cancer.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(6):339-43.
2005: Jian-Lin Wu; Na Li; Toshiaki Hasegawa; Jun-ichi Sakai; Saori Kakuta; Wanxia Tang; Seiko Oka; Miwa Kiuchi; Hirotsugu Ogura; Takao Kataoka; Akihiro Tomida; Takashi Tsuruo; Masayoshi Ando
Bioactive tetrahydrofuran lignans from Peperomia dindygulensis.
Journal of natural products 2005;68(11):1656-60.
2005: Toshiaki Saeki; Takashi Tsuruo; Wakao Sato; Kiyoshiro Nishikawsa
Drug resistance in chemotherapy for breast cancer.
Cancer chemotherapy and pharmacology 2005;56 Suppl 1():84-9.
2005: Naomi Haga; Naoya Fujita; Takashi Tsuruo
Involvement of mitochondrial aggregation in arsenic trioxide (As2O3)-induced apoptosis in human glioblastoma cells.
Cancer science 2005;96(11):825-33.
2005: Naotoshi Kanemitsu; Yukihiko Ebisuno; Toshiyuki Tanaka; Kazuhiro Otani; Haruko Hayasaka; Tsuneyasu Kaisho; Shizuo Akira; Koko Katagiri; Tatsuo Kinashi; Naoya Fujita; Takashi Tsuruo; Masayuki Miyasaka
CXCL13 is an arrest chemokine for B cells in high endothelial venules.
Blood 2005;106(8):2613-8.
2005: Anindya Goswami; Ravshan Burikhanov; Aurelie de Thonel; Naoya Fujita; Mamta Goswami; Yanming Zhao; John E Eriksson; Takashi Tsuruo; Vivek M Rangnekar
Binding and phosphorylation of par-4 by akt is essential for cancer cell survival.
Molecular cell 2005;20(1):33-44.
2005: Hideyuki Akaza; Takashi Tsuruo; Nagahiro Saijo; Saburo Sone; Seiji Isonishi; Yasuo Ohashi; Shinzaburo Noguchi; Junichi Kurebayashi; Yoshiyuki Kakehi; Hideki Ishikawa; George Blackledge
[Cancer prevention].
Gan to kagaku ryoho. Cancer & chemotherapy 2005;32(10):1499-506.
2005: Yukinari Kato; Mika Kaneko; Makoto Sata; Naoya Fujita; Takashi Tsuruo; Motoki Osawa
Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2005;26(4):195-200.
2005: Bayasi Guleng; Keisuke Tateishi; Miki Ohta; Fumihiko Kanai; Amarsanaa Jazag; Hideaki Ijichi; Yasuo Tanaka; Miwa Washida; Keita Morikane; Yasushi Fukushima; Takao Yamori; Takashi Tsuruo; Takao Kawabe; Makoto Miyagishi; Kazunari Taira; Masataka Sata; Masao Omata
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner.
Cancer research 2005;65(13):5864-71.
2005: Kazuhiro Katayama; Naoya Fujita; Takashi Tsuruo
Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition.
Molecular and cellular biology 2005;25(13):5725-37.
2005: Yumiko Aoyagi; Naoya Fujita; Takashi Tsuruo
Stabilization of integrin-linked kinase by binding to Hsp90.
Biochemical and biophysical research communications 2005;331(4):1061-8.
2005: Takashi Tsuruo
Tumorigenesis facilitated by Pten deficiency in the skin: evidence of p53-Pten complex formation on the initiation phase.
Cancer science 2005;96(6):377.
2005: Tetsuo Mashima; Tomoko Oh-hara; Shigeo Sato; Mikiko Mochizuki; Yoshikazu Sugimoto; Kanami Yamazaki; Jun-ichi Hamada; Mitsuhiro Tada; Tetsuya Moriuchi; Yuichi Ishikawa; Yo Kato; Hiroshi Tomoda; Takao Yamori; Takashi Tsuruo
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
Journal of the National Cancer Institute 2005;97(10):765-77.
2005: Keiko Sekine; Yanyan Hao; Yasuyuki Suzuki; Ryosuke Takahashi; Takashi Tsuruo; Mikihiko Naito
HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.
Biochemical and biophysical research communications 2005;330(1):279-85.
2005: Jiao Bai; Nobuhide Ito; Jun-ichi Sakai; Mutumi Kitabatake; Hajime Fujisawa; Liming Bai; Jungui Dai; Shujun Zhang; Katutoshi Hirose; Akihiro Tomida; Takashi Tsuruo; Masayoshi Ando
Taxoids and abietanes from callus cultures of Taxus cuspidata.
Journal of natural products 2005;68(4):497-501.
2005: Shinya Dohgu; Fuyuko Takata; Atsushi Yamauchi; Shinsuke Nakagawa; Takashi Egawa; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada; Masami Niwa; Yasufumi Kataoka
Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.
Brain research 2005;1038(2):208-15.
2005: Viqar Syed; Kasturi Mukherjee; James Lyons-Weiler; Kin-Mang Lau; Tetsuo Mashima; Takashi Tsuruo; Shuk-Mei Ho
Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling.
Oncogene 2005;24(10):1774-87.
2005: Jong-Hyuk Sung; Kyung-Ha Yu; Jin-Sun Park; Takashi Tsuruo; Dae-Duk Kim; Chang-Koo Shim; Suk-Jae Chung
Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(3):440-8.
2005: Hideyasu Murakami; Airi Ohkura; Hitomi Takanaga; Hirotami Matsuo; Noriko Koyabu; Mikihiko Naito; Takashi Tsuruo; Hisakazu Ohtani; Yasufumi Sawada
Functional characterization of adenosine transport across the BBB in mice.
International journal of pharmaceutics 2005;290(1-2):37-44.
2005: Hideyuki Akaza; Takashi Tsuruo; Nagahiro Saijo; Saburo Sone; Seiji Isonishi; Yasuo Ohashi; Tomotaka Sobue; Hidetoshi Yamanaka; Mamoru Fukuda; Masakazu Maruyama; Kenji Eguchi; Kazuto Ito; Mark Smith; Bob Milsted
[Cancer screening].
Gan to kagaku ryoho. Cancer & chemotherapy 2005;32(1):125-34.
2005: Hiroyuki Seimiya; Yukiko Muramatsu; Tomokazu Ohishi; Takashi Tsuruo
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Cancer cell 2005;7(1):25-37.
2004: Soji Kakiuchi; Yataro Daigo; Nobuhisa Ishikawa; Chiyuki Furukawa; Tatsuhiko Tsunoda; Seiji Yano; Kazuhiko Nakagawa; Takashi Tsuruo; Nobuoki Kohno; Masahiro Fukuoka; Saburo Sone; Yusuke Nakamura
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).
Human molecular genetics 2004;13(24):3029-43.
2004: Shinya Dohgu; Atsushi Yamauchi; Shinsuke Nakagawa; Fuyuko Takata; Mamiko Kai; Takashi Egawa; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada; Masami Niwa; Yasufumi Kataoka
Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes.
European journal of pharmacology 2004;505(1-3):51-9.
2004: Yukinari Kato; Isoji Sasagawa; Mika Kaneko; Motoki Osawa; Naoya Fujita; Takashi Tsuruo
Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors.
Oncogene 2004;23(52):8552-6.
2004: Geneviève Dufour; Marie-Josée Demers; David Gagné; Anders Dydensborg; Inga Christiane Teller; Véronique Bouchard; Isabelle Degongre; Jean-François Beaulieu; Jin Q Cheng; Naoya Fujita; Takashi Tsuruo; Karine Vallée; Pierre H Vachon
Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms.
The Journal of biological chemistry 2004;279(42):44113-22.
2004: Mikihiko Naito; Ryohei Katayama; Toshiyasu Ishioka; Akiko Suga; Kohei Takubo; Masahiro Nanjo; Chizuko Hashimoto; Masanori Taira; Shinji Takada; Ritsuko Takada; Masatoshi Kitagawa; Shu-Ichi Matsuzawa; John C Reed; Takashi Tsuruo
Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling.
Molecular and cellular biology 2004;24(19):8418-27.
2004: Tasneem Motiwala; Huban Kutay; Kalpana Ghoshal; Shoumei Bai; Hiroyuki Seimiya; Takashi Tsuruo; Saul Suster; Carl Morrison; Samson T Jacob
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13844-9.
2004: Noriko Uchiyama-Kokubu; Mikihiko Naito; Motowo Nakajima; Takashi Tsuruo
Transport of somatostatin and substance P by human P-glycoprotein.
FEBS letters 2004;574(1-3):55-61.
2004: Mika Kaneko; Yukinari Kato; Akiko Kunita; Naoya Fujita; Takashi Tsuruo; Motoki Osawa
Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells.
The Journal of biological chemistry 2004;279(37):38838-43.
2004: Hae-Ryong Park; Akihiro Tomida; Shigeo Sato; Yoshinori Tsukumo; Jisoo Yun; Takao Yamori; Yoichi Hayakawa; Takashi Tsuruo; Kazuo Shin-ya
Effect on tumor cells of blocking survival response to glucose deprivation.
Journal of the National Cancer Institute 2004;96(17):1300-10.
2004: Yanyan Hao; Keiko Sekine; Atsushi Kawabata; Hitoshi Nakamura; Toshiyasu Ishioka; Hirokazu Ohata; Ryohei Katayama; Chizuko Hashimoto; Xiaodong Zhang; Tetsuo Noda; Takashi Tsuruo; Mikihiko Naito
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function.
Nature cell biology 2004;6(9):849-60.
2004: Saori Sato; Naoya Fujita; Takashi Tsuruo
Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway.
The Journal of biological chemistry 2004;279(32):33759-67.
2004: Noriko Koyabu; Hitomi Takanaga; Hirotami Matsuo; Mikihiko Naito; Takashi Tsuruo; Hisakazu Ohtani; Yasufumi Sawada
Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line.
Drug metabolism and pharmacokinetics 2004;19(4):270-9.
2004: Jisoo Yun; Akihiro Tomida; Toshiwo Andoh; Takashi Tsuruo
Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.
The Journal of biological chemistry 2004;279(30):31296-303.
2004: Shinya Dohgu; Atsushi Yamauchi; Fuyuko Takata; Mikihiko Naito; Takashi Tsuruo; Shun Higuchi; Yasufumi Sawada; Yasufumi Kataoka
Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells.
Cellular and molecular neurobiology 2004;24(3):491-7.
2004: Shinya Dohgu; Atsushi Yamauchi; Fuyuko Takata; Yasufumi Sawada; Shun Higuchi; Mikihiko Naito; Takashi Tsuruo; Susumu Shirabe; Masami Niwa; Shigeru Katamine; Yasufumi Kataoka
Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier.
Cellular and molecular neurobiology 2004;24(2):205-17.
2004: Hideyuki Akaza; Masayuki Nakagawa; Takashi Tsuruo; Nagahiro Saijo; Saburo Sone; Nobuyuki Yamamoto; Yoshihiro Kakeji; Seigo Nakamura; Junichi Kurebayashi; Seiji Isonishi; Yasuo Ohashi; George Blackledge; James Carmichael
[Anti angiogenesis].
Gan to kagaku ryoho. Cancer & chemotherapy 2004;31(4):647-55.
2004: Mikihiko Naito; Chizuko Hashimoto; Shigeki Masui; Takashi Tsuruo
Caspase-independent necrotic cell death induced by a radiosensitizer, 8-nitrocaffeine.
Cancer science 2004;95(4):361-6.
2004: Yong J Lee; Christopher J Froelich; Naoya Fujita; Takashi Tsuruo; Jin H Kim
Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):1894-900.
2004: Ryoichi Yamaji; Kayoko Fujita; Isao Nakanishi; Kaori Nagao; Mikihiko Naito; Takashi Tsuruo; Hiroshi Inui; Yoshihisa Nakano
Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells.
Archives of biochemistry and biophysics 2004;423(2):332-42.
2004: Hiroyuki Seimiya; Yukiko Muramatsu; Susan Smith; Takashi Tsuruo
Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation.
Molecular and cellular biology 2004;24(5):1944-55.
2004: Kohichiroh Yasui; Saori Mihara; Chen Zhao; Hiroyuki Okamoto; Fumiko Saito-Ohara; Akihiro Tomida; Tadao Funato; Akira Yokomizo; Seiji Naito; Issei Imoto; Takashi Tsuruo; Johji Inazawa
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer research 2004;64(4):1403-10.
2004: Hua-Feng Zhang; Akihiro Tomida; Ritsuko Koshimizu; Yasunari Ogiso; Shuhong Lei; Takashi Tsuruo
Cullin 3 promotes proteasomal degradation of the topoisomerase I-DNA covalent complex.
Cancer research 2004;64(3):1114-21.
2004: Sung-Hoon Ahn; Seng-Ho Jeon; Takashi Tsuruo; Chang-Koo Shim; Suk-Jae Chung
Pharmacokinetic characterization of dehydroevodiamine in the rat brain.
Journal of pharmaceutical sciences 2004;93(2):283-92.
2004: Charlène Harnois; Marie-Josée Demers; Véronique Bouchard; Karine Vallée; David Gagné; Naoya Fujita; Takashi Tsuruo; Anne Vézina; Jean-François Beaulieu; André Côté; Pierre H Vachon
Human intestinal epithelial crypt cell survival and death: Complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways.
Journal of cellular physiology 2004;198(2):209-22.
2004: Hideyuki Akaza; Tomohiko Ichikawa; Takashi Tsuruo; Yasuhiro Shimada; Hisataka Moriwaki; Masaki Mori; Shinzaburo Noguchi; Seigo Nakamura; Nagahiro Saijo; Saburo Sone; Seiji Isonishi; Yasuo Ohashi; Shiro Hinotsu; Mikael von Euler; George Blackedge
[Molecule based diagnosis].
Gan to kagaku ryoho. Cancer & chemotherapy 2004;31(1):125-33.
2004: Jiao Bai; Mutumi Kitabatake; Kazuki Toyoizumi; Liwei Fu; Shujun Zhang; Jungui Dai; Jun-ichi Sakai; Katutoshi Hirose; Takao Yamori; Akihiro Tomida; Takashi Tsuruo; Masayoshi Ando
Production of biologically active taxoids by a callus culture of Taxus cuspidata.
Journal of natural products 2004;67(1):58-63.
2003: Yukinari Kato; Naoya Fujita; Akiko Kunita; Shigeo Sato; Mika Kaneko; Motoki Osawa; Takashi Tsuruo
Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors.
The Journal of biological chemistry 2003;278(51):51599-605.
2003: Naoya Fujita; Saori Sato; Takashi Tsuruo
Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization.
The Journal of biological chemistry 2003;278(49):49254-60.
2003: Yasuo Imai; Sakiyo Asada; Satomi Tsukahara; Etsuko Ishikawa; Takashi Tsuruo; Yoshikazu Sugimoto
Breast cancer resistance protein exports sulfated estrogens but not free estrogens.
Molecular pharmacology 2003;64(3):610-8.
2003: Naomi Haga; Naoya Fujita; Takashi Tsuruo
Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis.
Oncogene 2003;22(36):5579-85.
2003: Chen Jiang; Noriko Koyabu; Yoshikazu Yonemitsu; Takao Shimazoe; Shigenori Watanabe; Mikihiko Naito; Takashi Tsuruo; Hisakazu Ohtani; Yasufumi Sawada
In vivo delivery of glial cell-derived neurotrophic factor across the blood-brain barrier by gene transfer into brain capillary endothelial cells.
Human gene therapy 2003;14(12):1181-91.
2003: Naoya Fujita; Takashi Tsuruo
Survival-signaling pathway as a promising target for cancer chemotherapy.
Cancer chemotherapy and pharmacology 2003;52 Suppl 1():S24-8.
2003: Yoshikazu Sugimoto; Satomi Tsukahara; Shigeo Sato; Mutsumi Suzuki; Hiroyuki Nunoi; Harry L Malech; Michael M Gottesman; Takashi Tsuruo
Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91.
The journal of gene medicine 2003;5(5):366-76.
2003: Mika Shimonaka; Koko Katagiri; Toshinori Nakayama; Naoya Fujita; Takashi Tsuruo; Osamu Yoshie; Tatsuo Kinashi
Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow.
The Journal of cell biology 2003;161(2):417-27.
2003: Hideyuki Akaza; Masahiro Fukuoka; Atsushi Ohtsu; Michiyuki Usami; Tadashi Ikeda; Keisuke Aiba; Seiji Isonishi; Yasuo Ohashi; Nagahiro Saijo; Saburo Sone; Shigeru Tsukagoshi; Takashi Tsuruo; Masuhiro Kato; Osamu Mikami; Rui-Ping Dong; Mikael von Euler; George Blackledge; Don Stribling
[Globalization of clinical trials].
Gan to kagaku ryoho. Cancer & chemotherapy 2003;30(4):555-65.
2003: Takashi Tsuruo
[Translational research for cancer therapeutics].
Gan to kagaku ryoho. Cancer & chemotherapy 2003;30(4):449-54.
2003: Takashi Tsuruo
Molecular cancer therapeutics: recent progress and targets in drug resistance.
Internal medicine (Tokyo, Japan) 2003;42(3):237-43.
2003: Ryoichi Yamaji; Kayoko Fujita; Saeko Takahashi; Hiroko Yoneda; Kaori Nagao; Wataru Masuda; Mikihiko Naito; Takashi Tsuruo; Kazutaka Miyatake; Hiroshi Inui; Yoshihisa Nakano
Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger.
Biochimica et biophysica acta 2003;1593(2-3):269-76.
2003: Liling Yang; Tetsuo Mashima; Shigeo Sato; Mikiko Mochizuki; Hiroshi Sakamoto; Takao Yamori; Tomoko Oh-hara; Takashi Tsuruo
Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.
Cancer research 2003;63(4):831-7.
2003: Imad Naasani; Fujiko Oh-Hashi; Tomoko Oh-hara; Wan Yong Feng; Jeffrey Johnston; Kenneth Chan; Takashi Tsuruo
Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo.
Cancer research 2003;63(4):824-30.
2003: Wataru Yasui; Masahiko Nishiyama; Takashi Tsuruo; Eiichi Tahara
Molecular targeting therapy for cancer: the Twelfth International Symposium of the Hiroshima Cancer Seminar, November 2002.
Cancer science 2003;94(2):221-3.
2003: Takashi Tsuruo; Mikihiko Naito; Akihiro Tomida; Naoya Fujita; Tetsuo Mashima; Hiroshi Sakamoto; Naomi Haga
Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.
Cancer science 2003;94(1):15-21.
2003: Yoshikazu Sugimoto; Satomi Tsukahara; Yasuo Imai; Yoshikazu Sugimoto; Kazumitsu Ueda; Takashi Tsuruo
Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists.
Molecular cancer therapeutics 2003;2(1):105-12.
2002: Takashi Tsuruo
[New approach in drug designing: molecular-targeted drugs].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2002;91(12):3401-7.
2002: S Fujii; Joji Kitayama; Shoichi Kaisaki; Sei Sasaki; Y Seto; O Tominaga; Nelson H Tsuno; Naoyuki Umetani; H Yokota; K Kitamura; Takashi Tsuruo; Hirokazu Nagawa
Carcinoembryonic antigen mRNA in abdominal cavity as a useful predictor of peritoneal recurrence of gastric cancer with serosal exposure.
Journal of experimental & clinical cancer research : CR 2002;21(4):547-53.
2002: Susumu Rokudai; Naoya Fujita; Osamu Kitahara; Yusuke Nakamura; Takashi Tsuruo
Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis.
Molecular and cellular biology 2002;22(24):8695-708.
2002: Hiroshi Sakamoto; Tetsuo Mashima; Kazuo Yamamoto; Takashi Tsuruo
Modulation of heat-shock protein 27 (Hsp27) anti-apoptotic activity by methylglyoxal modification.
The Journal of biological chemistry 2002;277(48):45770-5.
2002: Koji Horie; Akihiro Tomida; Yoshikazu Sugimoto; Toshiharu Yasugi; Hiroyuki Yoshikawa; Yuji Taketani; Takashi Tsuruo
SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin.
Oncogene 2002;21(52):7913-22.
2002: Daniel Martin; Marta Salinas; Naoya Fujita; Takashi Tsuruo; Antonio Cuadrado
Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.
The Journal of biological chemistry 2002;277(45):42943-52.
2002: Hideyuki Akaza; Yasuo Ohashi; Yasuhiro Shimada; Tadashi Ikeda; Nagahiro Saijo; Seiji Isonishi; Yoshihiko Hirao; Takashi Tsuruo; Shigeru Tsukagoshi; Saburo Sone; Seigo Nakamura; Masuhiro Kato; Osamu Mikami; Mikael von Euler; George Blackledge; Bob Milsted; Brent Vose
[Post launch studies].
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(11):2037-48.
2002: Saori Sato; Naoya Fujita; Takashi Tsuruo
Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.
The Journal of biological chemistry 2002;277(42):39360-7.
2002: Yasunari Ogiso; Akihiro Tomida; Takashi Tsuruo
Nuclear localization of proteasomes participates in stress-inducible resistance of solid tumor cells to topoisomerase II-directed drugs.
Cancer research 2002;62(17):5008-12.
2002: Naoya Fujita; Saori Sato; Kazuhiro Katayama; Takashi Tsuruo
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
The Journal of biological chemistry 2002;277(32):28706-13.
2002: Yasuyuki Kaneta; Yoshitoyo Kagami; Toyomasa Katagiri; Tatsuhiko Tsunoda; Itsuro Jin-nai; Hirokuni Taguchi; Hisamaru Hirai; Kazunori Ohnishi; Takanori Ueda; Nobuhiko Emi; Akihiro Tomida; Takashi Tsuruo; Yusuke Nakamura; Ryuzo Ohno
Prediction of sensitivity to STI571 among chronic myeloid leukemia patients by genome-wide cDNA microarray analysis.
Japanese journal of cancer research : Gann 2002;93(8):849-56.
2002: Noriko Chikatsu; Yasuhiro Takeuchi; Seiji Fukumoto; Kazuki Yano; Naoya Fujita; Takashi Tsuruo; Toshiro Fujita
Clonal endothelial cells produce humoral factors that inhibit osteoclast-like cell formation in vitro.
Endocrine journal 2002;49(4):439-47.
2002: Chika Yamamoto; Hideyasu Murakami; Noriko Koyabu; Hitomi Takanaga; Hirotami Matsuo; Takeshi Uchiumi; Michihiko Kuwano; Mikihiko Naito; Takashi Tsuruo; Hisakazu Ohtani; Yasufumi Sawada
Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier.
The Journal of pharmacy and pharmacology 2002;54(8):1055-63.
2002: Atsushi Ishida; Naoya Fujita; Riko Kitazawa; Takashi Tsuruo
Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone.
The Journal of biological chemistry 2002;277(29):26217-24.
2002: Hiroyuki Seimiya; Tomoko Oh-hara; Tsuneji Suzuki; Imad Naasani; Toshiyuki Shimazaki; Katsutoshi Tsuchiya; Takashi Tsuruo
Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991.
Molecular cancer therapeutics 2002;1(9):657-65.
2002: Ken-ichi Hosoya; Masatoshi Tomi; Sumio Ohtsuki; Hitomi Takanaga; Shigeki Saeki; Yoshikatsu Kanai; Hitoshi Endou; Mikihiko Naito; Takashi Tsuruo; Tetsuya Terasaki
Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment.
The Journal of pharmacology and experimental therapeutics 2002;302(1):225-31.
2002: Yasuo Imai; Minoru Nakane; Kumie Kage; Satomi Tsukahara; Etsuko Ishikawa; Takashi Tsuruo; Yoshio Miki; Yoshikazu Sugimoto
C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.
Molecular cancer therapeutics 2002;1(8):611-6.
2002: Chen Jiang; Hirotami Matsuo; Noriko Koyabu; Hisakazu Ohtani; Hidenori Fujimoto; Yoshikazu Yonemitsu; Yasufumi Kaneda; Mikihiko Narro; Takashi Tsuruo; Yasufumi Sawada
Transluminal gene transfer into brain capillary endothelial cells in vivo with HVJ-liposomes.
Journal of drug targeting 2002;10(4):345-52.
2002: Makoto Murakami; Kumiko Yoshihara; Satoko Shimbara; Masatsugu Sawada; Naoki Inagaki; Hiroichi Nagai; Mikihiko Naito; Takashi Tsuruo; Tae Chul Moon; Hyeun Wook Chang; Ichiro Kudo
Group IID heparin-binding secretory phospholipase A(2) is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues.
European journal of biochemistry / FEBS 2002;269(11):2698-707.
2002: Kazuaki Nakanishi; Michiie Sakamoto; Jun Yasuda; Masaaki Takamura; Naoya Fujita; Takashi Tsuruo; Satoru Todo; Setsuo Hirohashi
Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer.
Cancer research 2002;62(10):2971-5.
2002: Jason Fontana; David J Fulton; Yan Chen; Todd A Fairchild; Timothy J McCabe; Naoya Fujita; Takashi Tsuruo; William C Sessa
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release.
Circulation research 2002;90(8):866-73.
2002: Yoko Hasumi; Hiroaki Mizukami; Masashi Urabe; Takahiro Kohno; Koichi Takeuchi; Akihiro Kume; Mikio Momoeda; Hiroyuki Yoshikawa; Takashi Tsuruo; Masabumi Shibuya; Yuji Taketani; Keiya Ozawa
Soluble FLT-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer.
Cancer research 2002;62(7):2019-23.
2002: Yoshimitsu Kimura; Jun Aoki; Masayuki Kohno; Hisayoshi Ooka; Takashi Tsuruo; Osamu Nakanishi
P-glycoprotein inhibition by the multidrug resistance-reversing agent MS-209 enhances bioavailability and antitumor efficacy of orally administered paclitaxel.
Cancer chemotherapy and pharmacology 2002;49(4):322-8.
2002: Naoya Fujita; Saori Sato; Atsushi Ishida; Takashi Tsuruo
Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.
The Journal of biological chemistry 2002;277(12):10346-53.
2002: Tomomi Ikegawa; Hisakazu Ohtani; Noriko Koyabu; Motoharu Juichi; Yukiko Iwase; Chihiro Ito; Hiroshi Furukawa; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada
Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.
Cancer letters 2002;177(1):89-93.
2002: Saori Sato; Naoya Fujita; Takashi Tsuruo
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).
Oncogene 2002;21(11):1727-38.
2002: Mitsuaki Tatsumi; Takashi Tsuruo; Tsunehiko Nishimura
Evaluation of MS-209, a novel multidrug-resistance-reversing agent, in tumour-bearing mice by technetium-99m-MIBI imaging.
European journal of nuclear medicine and molecular imaging 2002;29(3):288-94.
2002: Yasuo Imai; Satomi Tsukahara; Etsuko Ishikawa; Takashi Tsuruo; Yoshikazu Sugimoto
Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance.
Japanese journal of cancer research : Gann 2002;93(3):231-5.
2002: Ayako Nakashio; Naoya Fujita; Takashi Tsuruo
Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway.
International journal of cancer. Journal international du cancer 2002;98(1):36-41.
2002: Kumie Kage; Satomi Tsukahara; Tomomi Sugiyama; Sakiyo Asada; Etsuko Ishikawa; Takashi Tsuruo; Yoshikazu Sugimoto
Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization.
International journal of cancer. Journal international du cancer 2002;97(5):626-30.
2002: Hideyuki Akaza; Keisuke Aiba; Seiji Isonishi; Tadashi Ikeda; Yasuo Ohashi; Koji Kawai; Nagahiro Saijo; Toshiaki Saeki; Saburo Sone; Shigeru Tsukagoshi; Takashi Tsuruo; Narikazu Boku; Masuhiro Kato; Osamu Mikami; George Blackledge; Don Stribling
[Globalization of anti-cancer therapies].
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(2):205-14.
2002: Mikihiko Naito; Yasuhiro Matsuba; Shigeo Sato; Hiroshi Hirata; Takashi Tsuruo
MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):582-8.
2002: Masashi Sawada; Setsuko Moriya; Seiichi Saito; Ryuzaburo Shineha; Susumu Satomi; Takao Yamori; Takashi Tsuruo; Reiji Kannagi; Taeko Miyagi
Reduced sialidase expression in highly metastatic variants of mouse colon adenocarcinoma 26 and retardation of their metastatic ability by sialidase overexpression.
International journal of cancer. Journal international du cancer 2002;97(2):180-5.
2002: Eiji Sunami; Nelson H Tsuno; Joji Kitayama; Shinsuke Saito; Takuya Osada; Hironori Yamaguchi; Shigeru Tomozawa; Takashi Tsuruo; Yoichi Shibata; Hirokazu Nagawa
Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone.
Surgery today 2002;32(4):343-50.
2002: Imad Naasani; Takao Yamori; Takashi Tsuruo
Screening with COMPARE analysis for telomerase inhibitors.
Methods in molecular biology (Clifton, N.J.) 2002;191():197-207.
2001: Hideyuki Akaza; Toshiaki Saeki; Koji Kawai; Keisuke Aiba; Seiji Isonishi; Yasuo Ohashi; Saburo Sone; T Tamura; Shigeru Tsukagoshi; Takashi Tsuruo; Shinzaburo Noguchi; Tsuneharu Miki; Masuhiro Kato; Osamu Mikami; A Barge; George Blackledge
[Comparison of management of advanced cancer in various organs].
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(12):1845-55.
2001: H Suzuki; Akihiro Tomida; Takashi Tsuruo
Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia.
Oncogene 2001;20(41):5779-88.
2001: J Yano HKitayama; K Hatano; Nelson H Tsuno; T Osada; Tomomi Watanabe; Takashi Tsuruo; Tetsuichiro Muto; Hirokazu Nagawa
Clustered cancer cells show a distinct adhesion behavior from single cell form under physiological shear conditions.
Journal of experimental & clinical cancer research : CR 2001;20(3):407-12.
2001: Tetsuo Mashima; S Udagawa; Takashi Tsuruo
Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis.
Journal of cellular physiology 2001;188(3):352-8.
2001: Hiroshi Sakamoto; Tetsuo Mashima; Shigeo Sato; Y Hashimoto; Takao Yamori; Takashi Tsuruo
Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2513-8.
2001: K Yamane; E Katayama; Takashi Tsuruo
p53 contains a DNA break-binding motif similar to the functional part of BRCT-related region of Rb.
Oncogene 2001;20(23):2859-67.
2001: Hideyuki Akaza; Nagahiro Saijo; Keisuke Aiba; Seiji Isonishi; Yasuo Ohashi; Koji Kawai; T Konishi; Toshiaki Saeki; Saburo Sone; Shigeru Tsukagoshi; Takashi Tsuruo; Shinzaburo Noguchi; Tsuneharu Miki; Osamu Mikami; M Smith; G Hoctin-Boes; Don Stribling
[Platinum compounds in cancer therapy--past, present, and future].
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(5):625-35.
2000: K Yamane; E Katayama; Takashi Tsuruo
The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing feature.
Biochemical and biophysical research communications 2000;279(2):678-84.
2000: Shinya Dohgu; Yasufumi Kataoka; Hiroaki Ikesue; Mikihiko Naito; Takashi Tsuruo; Ryozo Oishi; Yasufumi Sawada
Involvement of glial cells in cyclosporine-increased permeability of brain endothelial cells.
Cellular and molecular neurobiology 2000;20(6):781-6.
2000: Tomomi Ikegawa; Fumihiko Ushigome; Noriko Koyabu; Satoshi Morimoto; Yukihiro Shoyama; Mikihiko Naito; Takashi Tsuruo; Hisakazu Ohtani; Yasufumi Sawada
Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.
Cancer letters 2000;160(1):21-8.
2000: T Nakagawa; Sakae Tanaka; H Suzuki; H Takayanagi; T Miyazaki; K Nakamura; Takashi Tsuruo
Overexpression of the csk gene suppresses tumor metastasis in vivo.
International journal of cancer. Journal international du cancer 2000;88(3):384-91.
2000: T Kageyama; M Nakamura; Akinori Matsuo; Y Yamasaki; Y Takakura; M Hashida; Y Kanai; M Naito; Takashi Tsuruo; Nagahiro Minato; Shun Shimohama
The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.
Brain research 2000;879(1-2):115-21.
2000: Hideyuki Akaza; Keisuke Aiba; Seiji Isonishi; O Ogawa; M Shibuya; Saburo Sone; Takashi Tsuruo; Shinzaburo Noguchi; Shiro Hinotsu; S Kono; Osamu Mikami; George Blackledge; B Vose; Don Stribling
[Development of molecular targeting drugs for the treatment of cancer-therapeutic potential and issues to be addressed in global development].
Gan to kagaku ryoho. Cancer & chemotherapy 2000;27(11):1681-93.
2000: Saori Sato; Naoya Fujita; Takashi Tsuruo
Modulation of Akt kinase activity by binding to Hsp90.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10832-7.
2000: A Nakashio; Naoya Fujita; Susumu Rokudai; S Sato; Takashi Tsuruo
Prevention of phosphatidylinositol 3'-kinase-Akt survival signaling pathway during topotecan-induced apoptosis.
Cancer research 2000;60(18):5303-9.
2000: K Kosugi; Jun-ichi Sakai; Shujun Zhang; Y Watanabe; H Sasaki; T Suzuki; H Hagiwara; N Hirata; Katutoshi Hirose; Masayoshi Ando; Akihiro Tomida; Takashi Tsuruo
Neutral taxoids from Taxus cuspidata as modulators of multidrug-resistant tumor cells.
Phytochemistry 2000;54(8):839-45.
2000: T Ishiguro; Hirokazu Nagawa; M Naito; Takashi Tsuruo
Inhibitory effect of ATF3 antisense oligonucleotide on ectopic growth of HT29 human colon cancer cells.
Japanese journal of cancer research : Gann 2000;91(8):833-6.
2000: Shigeru Tomozawa; Nelson H Tsuno; Eiji Sunami; K Hatano; Joji Kitayama; Takuya Osada; Shinsuke Saito; Takashi Tsuruo; Yoichi Shibata; Hirokazu Nagawa
Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer.
British journal of cancer 2000;83(3):324-8.
2000: Jun'ichi Kobayashi; Hideyuki Shigemori; H Hosoyama; Z Chen; S Akiyama; M Naito; Takashi Tsuruo
Multidrug resistance reversal activity of taxoids from Taxus cuspidata in KB-C2 and 2780AD cells.
Japanese journal of cancer research : Gann 2000;91(6):638-42.
2000: Hiroyuki Seimiya; H Sawada; Yukiko Muramatsu; M Shimizu; K Ohko; K Yamane; Takashi Tsuruo
Involvement of 14-3-3 proteins in nuclear localization of telomerase.
The EMBO journal 2000;19(11):2652-61.
2000: Hiroshi Sakamoto; Tetsuo Mashima; A Kizaki; S Dan; Y Hashimoto; Mikihiko Naito; Takashi Tsuruo
Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis.
Blood 2000;95(10):3214-8.
2000: Y Mitsunaga; Hitomi Takanaga; Hirotami Matsuo; Mikihiko Naito; Takashi Tsuruo; Hisakazu Ohtani; Yasufumi Sawada
Effect of bioflavonoids on vincristine transport across blood-brain barrier.
European journal of pharmacology 2000;395(3):193-201.
2000: K Yanase; Yoshikazu Sugimoto; S Tsukahara; Tomoko Oh-hara; T Andoh; Takashi Tsuruo
Identification and characterization of a deletion mutant of DNA topoisomerase I mRNA in a camptothecin-resistant subline of human colon carcinoma.
Japanese journal of cancer research : Gann 2000;91(5):551-9.
2000: Yasunari Ogiso; Akihiro Tomida; S Lei; S Omura; Takashi Tsuruo
Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs.
Cancer research 2000;60(9):2429-34.
2000: K Yamane; E Katayama; K Sugasawa; Takashi Tsuruo
Retinoblastoma susceptibility protein, Rb, possesses multiple BRCT-Ws, BRCA1 carboxyl-terminus-related W regions with DNA break-binding activity.
Oncogene 2000;19(16):1982-91.
2000: Tomohiro Takenoue; Hirokazu Nagawa; K Matsuda; S Fujii; Marcelo Eidi Nita; K Hatano; Joji Kitayama; Takashi Tsuruo; Tetsuichiro Muto
Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method.
Annals of surgical oncology 2000;7(3):193-8.
2000: Shinichi Torii; K Yamane; Tetsuo Mashima; Naomi Haga; K Yamamoto; J W Fox; M Naito; Takashi Tsuruo
Molecular cloning and functional analysis of apoxin I, a snake venom-derived apoptosis-inducing factor with L-amino acid oxidase activity.
Biochemistry 2000;39(12):3197-205.
2000: Tomohiro Takenoue; Joji Kitayama; Y Takei; Naoyuki Umetani; K Matsuda; Marcelo Eidi Nita; K Hatano; Takashi Tsuruo; Hirokazu Nagawa
Characterization of dihydropyrimidine dehydrogenase on immunohistochemistry in colon carcinoma, and correlation between immunohistochemical score and protein level or messenger RNA expression.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(3):273-9.
2000: Susumu Rokudai; Naoya Fujita; Y Hashimoto; Takashi Tsuruo
Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis.
Journal of cellular physiology 2000;182(2):290-6.
2000: Hirotami Matsuo; T Okamura; J Chen; Hitomi Takanaga; Hisakazu Ohtani; Yasufumi Kaneda; M Naito; Takashi Tsuruo; Yasufumi Sawada
Efficient introduction of macromolecules and oligonucleotides into brain capillary endothelial cells using HVJ-liposomes.
Journal of drug targeting 2000;8(4):207-16.
2000: Eiji Sunami; Nelson H Tsuno; Takuya Osada; Shinsuke Saito; Joji Kitayama; Shigeru Tomozawa; Takashi Tsuruo; Yoichi Shibata; Tetsuichiro Muto; Hirokazu Nagawa
MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer.
The oncologist 2000;5(2):108-14.
1999: Y Zhang; Naoya Fujita; Takashi Tsuruo
p21Waf1/Cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line.
International journal of cancer. Journal international du cancer 1999;83(6):790-7.
1999: Shigeru Tomozawa; Hirokazu Nagawa; Nelson H Tsuno; K Hatano; Takuya Osada; Joji Kitayama; Eiji Sunami; Marcelo Eidi Nita; S Ishihara; H Yano; Takashi Tsuruo; Yoichi Shibata; Tetsuichiro Muto
Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
British journal of cancer 1999;81(8):1274-9.
1999: Z Chen; Makoto Naito; Satoko Hori; T Mashima; T Yamori; Takashi Tsuruo
A human IAP-family gene, apollon, expressed in human brain cancer cells.
Biochemical and biophysical research communications 1999;264(3):847-54.
1999: Hideyuki Akaza; Takashi Tsuruo; Taiji Tsukamoto; Shinzaburo Noguchi; H Moriwaki; Seiji Isonishi; N Masuda; Shiro Hinotsu; A F Nash; Mikael von Euler; J Wildin; Don Stribling
[Early detection and prevention of cancers in various therapeutic areas. Discussion].
Gan to kagaku ryoho. Cancer & chemotherapy 1999;26(11):1585-97.
1999: K Yamane; Takashi Tsuruo
Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA.
Oncogene 1999;18(37):5194-203.
1999: Imad Naasani; Hiroyuki Seimiya; Takao Yamori; Takashi Tsuruo
FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis.
Cancer research 1999;59(16):4004-11.
1999: M Hirotani; Y Zhang; Naoya Fujita; M Naito; Takashi Tsuruo
NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis.
The Journal of biological chemistry 1999;274(29):20415-20.
1999: Hiroyuki Seimiya; M Tanji; Tomoko Oh-hara; Akihiro Tomida; Imad Naasani; Takashi Tsuruo
Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells.
Biochemical and biophysical research communications 1999;260(2):365-70.
1999: N Sawada; Hitomi Takanaga; Hirotami Matsuo; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada
Choline uptake by mouse brain capillary endothelial cells in culture.
The Journal of pharmacy and pharmacology 1999;51(7):847-52.
1999: Marcelo Eidi Nita; Hirokazu Nagawa; O Tominaga; Nelson H Tsuno; K Hatano; Joji Kitayama; Takashi Tsuruo; C E Domene; Tetsuichiro Muto
p21Waf1/Cip1 expression is a prognostic marker in curatively resected esophageal squamous cell carcinoma, but not p27Kip1, p53, or Rb.
Annals of surgical oncology 1999;6(5):481-8.
1999: H D Kim; Akihiro Tomida; Yasunari Ogiso; Takashi Tsuruo
Glucose-regulated stresses cause degradation of DNA topoisomerase IIalpha by inducing nuclear proteasome during G1 cell cycle arrest in cancer cells.
Journal of cellular physiology 1999;180(1):97-104.
1999: S Mizukami; Kazuya Kikuchi; T Higuchi; Y Urano; T Mashima; Takashi Tsuruo; Tetsuo Nagano
Imaging of caspase-3 activation in HeLa cells stimulated with etoposide using a novel fluorescent probe.
FEBS letters 1999;453(3):356-60.
1999: S Kochi; Hitomi Takanaga; Hirotami Matsuo; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada
Effect of cyclosporin A or tacrolimus on the function of blood-brain barrier cells.
European journal of pharmacology 1999;372(3):287-95.
1999: Yasunari Ogiso; Akihiro Tomida; H D Kim; Takashi Tsuruo
Glucose starvation and hypoxia induce nuclear accumulation of proteasome in cancer cells.
Biochemical and biophysical research communications 1999;258(2):448-52.
1999: H Kita; Hirotami Matsuo; Hitomi Takanaga; J Kawakami; Kazuhiko Yamamoto; Tatsuji Iga; M Naito; Takashi Tsuruo; A Asanuma; K Yanagisawa; Yasufumi Sawada
In vivo and in vitro toxicodynamic analyses of new quinolone-and nonsteroidal anti-inflammatory drug-induced effects on the central nervous system.
Antimicrobial agents and chemotherapy 1999;43(5):1091-7.
1999: T Nakagawa; Naoya Fujita; T Oh-hara; T Kurokawa; K Nakamura; Takashi Tsuruo
Interleukin-1 alpha induced cyclooxygenase-2 expression in bone-derived endothelial cells.
Journal of cellular physiology 1999;179(2):226-32.
1999: Tetsuo Mashima; Mikihiko Naito; Takashi Tsuruo
Caspase-mediated cleavage of cytoskeletal actin plays a positive role in the process of morphological apoptosis.
Oncogene 1999;18(15):2423-30.
1999: K Yanase; Yoshikazu Sugimoto; T Andoh; Takashi Tsuruo
Retroviral expression of a mutant (Gly-533) human DNA topoisomerase I cDNA confers a dominant form of camptothecin resistance.
International journal of cancer. Journal international du cancer 1999;81(1):134-40.
1999: J Matsuzaki; C Yamamoto; T Miyama; Hitomi Takanaga; Hirotami Matsuo; H Ishizuka; Y Kawahara; Michihiko Kuwano; M Naito; Takashi Tsuruo; Yasufumi Sawada
Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier.
Biopharmaceutics & drug disposition 1999;20(2):85-90.
1999: S Dan; Mikihiko Naito; Hiroyuki Seimiya; A Kizaki; Tetsuo Mashima; Takashi Tsuruo
Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells.
Oncogene 1999;18(6):1277-83.
1999: H Hosoyama; Hideyuki Shigemori; A Tomida; Takashi Tsuruo; Jun'ichi Kobayashi
Modulation of multidrug resistance in tumor cells by taxinine derivatives.
Bioorganic & medicinal chemistry letters 1999;9(3):389-94.
1999: Y Zhang; Naoya Fujita; Takashi Tsuruo
Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis.
Oncogene 1999;18(5):1131-8.
1999: K Kage; Naoya Fujita; T Oh-hara; E Ogata; T Fujita; Takashi Tsuruo
Basic fibroblast growth factor induces cyclooxygenase-2 expression in endothelial cells derived from bone.
Biochemical and biophysical research communications 1999;254(1):259-63.
1999: Z Chen; Hiroyuki Seimiya; Mikihiko Naito; Tetsuo Mashima; A Kizaki; S Dan; M Imaizumi; H Ichijo; K Miyazono; Takashi Tsuruo
ASK1 mediates apoptotic cell death induced by genotoxic stress.
Oncogene 1999;18(1):173-80.
1999: M Yamada; Akihiro Tomida; Jisoo Yun; B Cai; H Yoshikawa; Y Taketani; Takashi Tsuruo
Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress.
Cancer chemotherapy and pharmacology 1999;44(1):59-64.
1999: Y Seto; Hirokazu Nagawa; Masatomo Mori; Takashi Tsuruo; Tetsuichiro Muto
Effect of 5-fluorouracil on gastrointestinal carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
Digestive diseases and sciences 1999;44(1):75-8.
1999: M Homma; Hiroshi Suzuki; Hiroyuki Kusuhara; M Naito; Takashi Tsuruo; Yuichi Sugiyama
High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).
The Journal of pharmacology and experimental therapeutics 1999;288(1):198-203.
1998: S Fujii; O Tominaga; Hirokazu Nagawa; Nelson H Tsuno; Marcelo Eidi Nita; Takashi Tsuruo; Tetsuichiro Muto
Quantitative analysis of the cyclin expression in human esophageal cancer cell lines.
Journal of experimental & clinical cancer research : CR 1998;17(4):491-6.
1998: Marcelo Eidi Nita; O Tominaga; Hirokazu Nagawa; Takashi Tsuruo; Tetsuichiro Muto
Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer.
Hepato-gastroenterology 1998;45(24):2117-22.
1998: Hiroshi Suzuki; A Tomida; Takashi Tsuruo
A novel mutant from apoptosis-resistant colon cancer HT-29 cells showing hyper-apoptotic response to hypoxia, low glucose and cisplatin.
Japanese journal of cancer research : Gann 1998;89(11):1169-78.
1998: B Cai; Akihiro Tomida; K Mikami; K Nagata; Takashi Tsuruo
Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions.
Journal of cellular physiology 1998;177(2):282-8.
1998: M Iwata; Hiroyuki Nunoi; I Matsuda; Shiro Kanegasaki; Takashi Tsuruo; Yoshikazu Sugimoto
Drug-selected complete restoration of superoxide generation in Epstein-Barr virus-transformed B cells from p47phox-deficient chronic granulomatous disease patients by using a bicistronic retrovirus vector encoding a human multi-drug resistance gene (MDR1) and the p47phox gene.
Human genetics 1998;103(4):419-23.
1998: Marcelo Eidi Nita; Hirokazu Nagawa; O Tominaga; Nelson H Tsuno; S Fujii; Sei Sasaki; Chuan-gang Fu; Tomohiro Takenoue; Takashi Tsuruo; Tetsuichiro Muto
5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins.
British journal of cancer 1998;78(8):986-92.
1998: Naoya Fujita; A Nagahashi; K Nagashima; Susumu Rokudai; Takashi Tsuruo
Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases.
Oncogene 1998;17(10):1295-304.
1998: Tetsuo Mashima; Hiroyuki Seimiya; Z Chen; S Kataoka; Takashi Tsuruo
Apoptosis resistance in tumor cells.
Cytotechnology 1998;27(1-3):293-308.
1998: J Dong; Mikihiko Naito; S Dan; Takashi Tsuruo
Establishment of a mutant from human monocytic leukaemia U937 that exhibits a genetically dominant resistance to TNF alpha-induced apoptosis.
Apoptosis : an international journal on programmed cell death 1998;3(4):245-54.
1998: K Mikami; M Naito; T Ishiguro; H Yano; Akihiro Tomida; T Yamada; N Tanaka; T Shirakusa; Takashi Tsuruo
Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase.
Japanese journal of cancer research : Gann 1998;89(9):910-5.
1998: Hitomi Takanaga; Hideyasu Murakami; Noriko Koyabu; Hirotami Matsuo; Mikihiko Naito; Takashi Tsuruo; Yasufumi Sawada
Efflux transport of tolbutamide across the blood-brain barrier.
The Journal of pharmacy and pharmacology 1998;50(9):1027-33.
1998: Imad Naasani; Hiroyuki Seimiya; Takashi Tsuruo
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
Biochemical and biophysical research communications 1998;249(2):391-6.
1998: Hiroyuki Seimiya; Takashi Tsuruo
Functional involvement of PTP-U2L in apoptosis subsequent to terminal differentiation of monoblastoid leukemia cells.
The Journal of biological chemistry 1998;273(33):21187-93.
1998: S Dan; Mikihiko Naito; Takashi Tsuruo
Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR - ABL tyrosine kinase, CGP 57148.
Cell death and differentiation 1998;5(8):710-5.
1998: T Miyama; Hitomi Takanaga; Hirotami Matsuo; Katsuhiro Yamano; Kazuhiko Yamamoto; Tatsuji Iga; M Naito; Takashi Tsuruo; H Ishizuka; Y Kawahara; Yasufumi Sawada
P-glycoprotein-mediated transport of itraconazole across the blood-brain barrier.
Antimicrobial agents and chemotherapy 1998;42(7):1738-44.
1998: Jun'ichi Kobayashi; H Hosoyama; X X Wang; Hideyuki Shigemori; Y Sudo; Takashi Tsuruo
Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.
Bioorganic & medicinal chemistry letters 1998;8(12):1555-8.
1998: M Suzuki; Y Sugimoto; Takashi Tsuruo
Efficient protection of cells from the genotoxicity of nitrosoureas by the retrovirus-mediated transfer of human O6-methylguanine-DNA methyltransferase using bicistronic vectors with human multidrug resistance gene 1.
Mutation research 1998;401(1-2):133-41.
1998: Hiroyuki Kusuhara; Hiroshi Suzuki; M Naito; Takashi Tsuruo; Yuichi Sugiyama
Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1260-5.
1998: Y Morinaga; Naoya Fujita; K Ohishi; Y Zhang; Takashi Tsuruo
Suppression of interleukin-11-mediated bone resorption by cyclooxygenases inhibitors.
Journal of cellular physiology 1998;175(3):247-54.
1998: Naoya Fujita; Takashi Tsuruo
Involvement of Bcl-2 cleavage in the acceleration of VP-16-induced U937 cell apoptosis.
Biochemical and biophysical research communications 1998;246(2):484-8.
1998: Naomi Haga; Mikihiko Naito; Hiroyuki Seimiya; Akihiro Tomida; J Dong; Takashi Tsuruo
2-Deoxyglucose inhibits chemotherapeutic drug-induced apoptosis in human monocytic leukemia U937 cells with inhibition of c-Jun N-terminal kinase 1/stress-activated protein kinase activation.
International journal of cancer. Journal international du cancer 1998;76(1):86-90.
1998: Y Zhang; Naoya Fujita; T Oh-hara; Y Morinaga; T Nakagawa; M Yamada; Takashi Tsuruo
Production of interleukin-11 in bone-derived endothelial cells and its role in the formation of osteolytic bone metastasis.
Oncogene 1998;16(6):693-703.
1998: J Dong; Mikihiko Naito; Tetsuo Mashima; W H Jang; Takashi Tsuruo
Genetically recessive mutant of human monocytic leukemia U937 resistant to tumor necrosis factor-alpha-induced apoptosis.
Journal of cellular physiology 1998;174(2):179-85.
1998: Y Kato; S Hori; Naoya Fujita; Takashi Tsuruo
A novel anti-platelet monoclonal antibody induces mouse platelet aggregation through an Fc receptor-independent mechanism.
Biochemical and biophysical research communications 1998;242(2):250-5.
1998: Y Sugimoto; Michael M Gottesman; Ira Pastan; Takashi Tsuruo
Construction of MDR1 vectors for gene therapy.
Methods in enzymology 1998;292():523-37.
1998: M Naito; Takashi Tsuruo
Monoclonal antibodies to P-glycoprotein: preparation and applications to basic and clinical research.
Methods in enzymology 1998;292():258-65.
1998: Chuan-gang Fu; O Tominaga; Hirokazu Nagawa; Marcelo Eidi Nita; T Masaki; G Ishimaru; Y Higuchi; Takashi Tsuruo; Tetsuichiro Muto
Role of p53 and p21/WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients.
Diseases of the colon and rectum 1998;41(1):68-74.
1997: K Yamane; M Kawabata; Takashi Tsuruo
A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator.
European journal of biochemistry / FEBS 1997;250(3):794-9.
1997: Mikihiko Naito; K Shiina; Tetsuo Mashima; K Nagashima; Takashi Tsuruo
Induction of in vitro nuclear apoptosis activity coincides with the production of 50 kDa cytosolic protein.
Cell death and differentiation 1997;4(7):617-22.
1997: Y Mano; Hiroshi Suzuki; Tetsuya Terasaki; T Iwahashi; K Ono; M Naito; Takashi Tsuruo; Yuichi Sugiyama
Kinetic analysis of the disposition of MRK16, an anti-P-glycoprotein monoclonal antibody, in tumors: comparison between in vitro and in vivo disposition.
The Journal of pharmacology and experimental therapeutics 1997;283(1):391-401.
1997: T Ohta; Taroh Kinoshita; Makoto Naito; T Nozaki; M Masutani; Takashi Tsuruo; Atsushi Miyajima
Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells.
The Journal of biological chemistry 1997;272(37):23111-6.
1997: O Tominaga; Marcelo Eidi Nita; Hirokazu Nagawa; S Fujii; Takashi Tsuruo; Tetsuichiro Muto
Expressions of cell cycle regulators in human colorectal cancer cell lines.
Japanese journal of cancer research : Gann 1997;88(9):855-60.
1997: K Mikami; T Shirakusa; Takashi Tsuruo
[DT-diaphorase].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(11):1606-10.
1997: Tetsuo Mashima; Takashi Tsuruo
[ICE family proteins].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(11):1454-9.
1997: J Dong; Mikihiko Naito; Takashi Tsuruo
c-Myc plays a role in cellular susceptibility to death receptor-mediated and chemotherapy-induced apoptosis in human monocytic leukemia U937 cells.
Oncogene 1997;15(6):639-47.
1997: S Fukuda; T Kuroki; H Kohsaki; S Hayashi; K Ozaki; T Yamori; Takashi Tsuruo; S Nakamori; S Imaoka; Yusuke Nakamura
Isolation of a novel gene showing reduced expression in metastatic colorectal carcinoma cell lines and carcinomas.
Japanese journal of cancer research : Gann 1997;88(8):725-31.
1997: Y Kato; N Fujita; H Yano; Takashi Tsuruo
Suppression of experimental lung colonization of mouse colon adenocarcinoma 26 in vivo by an anti-idiotype monoclonal antibody recognizing a platelet surface molecule.
Cancer research 1997;57(14):3040-5.
1997: M Suzuki; Y Sugimoto; S Tsukahara; E Okochi; Michael M Gottesman; Takashi Tsuruo
Retroviral coexpression of two different types of drug resistance genes to protect normal cells from combination chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(6):947-54.
1997: Y Morinaga; Naoya Fujita; K Ohishi; Takashi Tsuruo
Stimulation of interleukin-11 production from osteoblast-like cells by transforming growth factor-beta and tumor cell factors.
International journal of cancer. Journal international du cancer 1997;71(3):422-8.
1997: Naoya Fujita; N Kodama; Y Kato; S H Lee; Takashi Tsuruo
Aggregation of Thy-1 glycoprotein induces thymocyte apoptosis through activation of CPP32-like proteases.
Experimental cell research 1997;232(2):400-6.
1997: Shinichi Torii; M Naito; Takashi Tsuruo
Apoxin I, a novel apoptosis-inducing factor with L-amino acid oxidase activity purified from Western diamondback rattlesnake venom.
The Journal of biological chemistry 1997;272(14):9539-42.
1997: T Watanabe; M Naito; N Kokubu; Takashi Tsuruo
Regression of established tumors expressing P-glycoprotein by combinations of adriamycin, cyclosporin derivatives, and MRK-16 antibodies.
Journal of the National Cancer Institute 1997;89(7):512-8.
1997: Y Sugimoto; Takashi Tsuruo
In vivo drug-selectable markers in gene therapy.
Leukemia 1997;11 Suppl 3():552-6.
1997: Mikihiko Naito; K Nagashima; Tetsuo Mashima; Takashi Tsuruo
Phosphatidylserine externalization is a downstream event of interleukin-1 beta-converting enzyme family protease activation during apoptosis.
Blood 1997;89(6):2060-6.
1997: Tetsuo Mashima; Mikihiko Naito; K Noguchi; D K Miller; D W Nicholson; Takashi Tsuruo
Actin cleavage by CPP-32/apopain during the development of apoptosis.
Oncogene 1997;14(9):1007-12.
1997: Hiroyuki Seimiya; Tetsuo Mashima; M Toho; Takashi Tsuruo
c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis.
The Journal of biological chemistry 1997;272(7):4631-6.
1997: S H Lee; N Fujita; Takashi Tsuruo
Activation of a CPP32-like protease during L1210 cell apoptosis induced by thiol deprivation.
Apoptosis : an international journal on programmed cell death 1997;2(1):77-83.
1997: M Naito; Takashi Tsuruo
New multidrug-resistance-reversing drugs, MS-209 and SDZ PSC 833.
Cancer chemotherapy and pharmacology 1997;40 Suppl():S20-4.
1997: M Yamada; Akihiro Tomida; H Yoshikawa; Y Taketani; Takashi Tsuruo
Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines.
Cancer chemotherapy and pharmacology 1997;40(1):31-7.
1997: Tetsuo Mashima; Takashi Tsuruo
[Involvement of ICE/CED 3 family proteases in antitumor agent-induced apoptosis].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(2):211-5.
1997: Y Sugimoto; S Sato; S Tsukahara; M Suzuki; E Okochi; Michael M Gottesman; Ira Pastan; Takashi Tsuruo
Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.
Cancer gene therapy 1997;4(1):51-8.
1996: Akihiro Tomida; H Suzuki; H D Kim; Takashi Tsuruo
Glucose-regulated stresses cause decreased expression of cyclin D1 and hypophosphorylation of retinoblastoma protein in human cancer cells.
Oncogene 1996;13(12):2699-705.
1996: S H Lee; Naoya Fujita; Tetsuo Mashima; Takashi Tsuruo
Interleukin-7 inhibits apoptosis of mouse malignant T-lymphoma cells by both suppressing the CPP32-like protease activation and inducing the Bcl-2 expression.
Oncogene 1996;13(10):2131-9.
1996: Z Chen; M Naito; Tetsuo Mashima; Takashi Tsuruo
Activation of actin-cleavable interleukin 1beta-converting enzyme (ICE) family protease CPP-32 during chemotherapeutic agent-induced apoptosis in ovarian carcinoma cells.
Cancer research 1996;56(22):5224-9.
1996: Akihiro Tomida; J Yun; Takashi Tsuruo
Glucose-regulated stresses induce resistance to camptothecin in human cancer cells.
International journal of cancer. Journal international du cancer 1996;68(3):391-6.
1996: M Naito; T Watanabe; H Tsuge; T Koyama; T Oh-hara; Takashi Tsuruo
Potentiation of the reversal activity of SDZ PSC833 on multi-drug resistance by an anti-P-glycoprotein monoclonal antibody MRK-16.
International journal of cancer. Journal international du cancer 1996;67(3):435-40.
1996: Seiji Yano; Yasuhiko Nishioka; K Izumi; Takashi Tsuruo; T Tanaka; M Miyasaka; Saburo Sone
Novel metastasis model of human lung cancer in SCID mice depleted of NK cells.
International journal of cancer. Journal international du cancer 1996;67(2):211-7.
1996: K Noguchi; M Naito; M Oshimura; Tetsuo Mashima; N Fujita; S Yonehara; Takashi Tsuruo
Chromosome 22 complements apoptosis in Fas-and TNF-resistant mutant UK110 cells.
Oncogene 1996;13(1):39-46.
1996: K Mikami; M Naito; Akihiro Tomida; M Yamada; T Sirakusa; Takashi Tsuruo
DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.
Cancer research 1996;56(12):2823-6.
1996: Naoya Fujita; Y Kato; M Naito; Takashi Tsuruo
A novel anti-Thy-1 (CD90) monoclonal antibody induces apoptosis in mouse malignant T-lymphoma cells in spite of inducing bcl-2 expression.
International journal of cancer. Journal international du cancer 1996;66(4):544-50.
1996: T Ishiguro; M Nakajima; M Naito; T Muto; Takashi Tsuruo
Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials.
Cancer research 1996;56(4):875-9.
1996: M Yamada; A Tomida; H Yoshikawa; Y Taketani; Takashi Tsuruo
Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(2):427-32.
1996: T Watanabe; M Naito; T Oh-hara; Y Itoh; D Cohen; Takashi Tsuruo
Modulation of multidrug resistance by SDZ PSC 833 in leukemic and solid-tumor-bearing mouse models.
Japanese journal of cancer research : Gann 1996;87(2):184-93.
1996: M Kamishohara; H Kawai; T Sakai; T Uchida; Takashi Tsuruo; N Otake
Inhibitory effect of a spicamycin derivative, KRN5500, on the growth of hepatic metastasis of human colon cancer-producing tissue polypeptide antigen.
Cancer chemotherapy and pharmacology 1996;38(6):495-8.
1996: H Fujii; M Nakajima; T Aoyagi; Takashi Tsuruo
Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors.
Biological & pharmaceutical bulletin 1996;19(1):6-10.
1995: Tetsuo Mashima; M Naito; Naoya Fujita; K Noguchi; Takashi Tsuruo
Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis.
Biochemical and biophysical research communications 1995;217(3):1185-92.
1995: T Sakai; H Kawai; M Kamishohara; A Odagawa; A Suzuki; T Uchida; T Kawasaki; Takashi Tsuruo; N Otake
Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives.
The Journal of antibiotics 1995;48(12):1467-80.
1995: K Yusa; J Tamura; A Waki; Takashi Tsuruo
Activation of silent MDR1 genes in revertant cells by fusion with multidrug-resistant cells.
Biochimica et biophysica acta 1995;1269(3):260-6.
1995: E Okochi; T Iwahashi; K Ariyoshi; H Watabe; Takashi Tsuruo; K Ono
Establishment and evaluation of MRK16-magnetic cell sorting assays for detecting low expression of multidrug resistance P-glycoprotein using human leukemia cell lines and peripheral blood cells from healthy donors.
Journal of immunological methods 1995;187(1):127-37.
1995: Hiroyuki Seimiya; T Sawabe; M Toho; Takashi Tsuruo
Phorbol ester-resistant monoblastoid leukemia cells with a functional mitogen-activated protein kinase cascade but without responsive protein tyrosine phosphatases.
Oncogene 1995;11(10):2047-54.
1995: K Noguchi; M Naito; S Kataoka; S Yonehara; Takashi Tsuruo
A recessive mutant of the U937 cell line acquired resistance to anti-Fas and anti-p55 tumor necrosis factor receptor antibody-induced apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(10):1271-7.
1995: T Watanabe; H Suzuki; Yasufumi Sawada; M Naito; Takashi Tsuruo; M Inaba; Manabu Hanano; Yuichi Sugiyama
Induction of hepatic P-glycoprotein enhances biliary excretion of vincristine in rats.
Journal of hepatology 1995;23(4):440-8.
1995: H Fujii; M Nakajima; I Saiki; J Yoneda; I Azuma; Takashi Tsuruo
Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13.
Clinical & experimental metastasis 1995;13(5):337-44.
1995: H Yamaki; M Nakajima; Hiroyuki Seimiya; H Saya; M Sugita; Takashi Tsuruo
Inhibition of the association with nuclear matrix of pRB, p70 and p40 proteins along with the specific suppression of c-MYC expression by geldanamycin, an inhibitor of Src tyrosine kinase.
The Journal of antibiotics 1995;48(9):1021-6.
1995: S H Lee; Naoya Fujita; K Imai; Takashi Tsuruo
Cysteine produced from lymph node stromal cells suppresses apoptosis of mouse malignant T-lymphoma cells.
Biochemical and biophysical research communications 1995;213(3):837-44.
1995: R Nabioullin; H Yanagawa; T Haku; K Hiramatsu; Seiji Yano; Masaki Hanibuchi; K Pai; Takashi Tsuruo; Saburo Sone
Influence of systemic chemotherapy on anti-P-glycoprotein antibody-dependent cell-mediated cytotoxicity in patients with small cell lung cancer.
Japanese journal of clinical oncology 1995;25(4):124-30.
1995: K Ohishi; Naoya Fujita; Y Morinaga; Takashi Tsuruo
H-31 human breast cancer cells stimulate type I collagenase production in osteoblast-like cells and induce bone resorption.
Clinical & experimental metastasis 1995;13(4):287-95.
1995: T Sakai; H Kawai; M Kamishohara; A Odagawa; A Suzuki; T Uchida; T Kawasaki; Takashi Tsuruo; N Otake
Synthesis and antitumor activities of glycine-exchanged analogs of spicamycin.
The Journal of antibiotics 1995;48(6):504-8.
1995: K Hanaoka; N Fujita; S H Lee; Hiroyuki Seimiya; M Naito; Takashi Tsuruo
Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells.
Cancer research 1995;55(10):2186-90.
1995: Hiroyuki Seimiya; T Sawabe; J Inazawa; Takashi Tsuruo
Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents.
Oncogene 1995;10(9):1731-8.
1995: Tetsuo Mashima; M Naito; S Kataoka; H Kawai; Takashi Tsuruo
Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells.
Biochemical and biophysical research communications 1995;209(3):907-15.
1995: N Fujita; M Naito; S H Lee; K Hanaoka; Takashi Tsuruo
Apoptosis inhibition by anti-M(r) 23,000 (Thy-1) monoclonal antibodies without inducing bcl-2 expression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(4):355-62.
1995: M Toyoshima; M Nakajima; T Yamori; Takashi Tsuruo
Purification and characterization of the platelet-aggregating sialoglycoprotein gp44 expressed by highly metastatic variant cells of mouse colon adenocarcinoma 26.
Cancer research 1995;55(4):767-73.
1995: Takashi Tsuruo
[Development of drugs to overcome drug resistance--basic approaches].
Gan to kagaku ryoho. Cancer & chemotherapy 1995;22(3):365-70.
1995: Akihiro Tomida; M Naito; Takashi Tsuruo
Acute induction of adriamycin-resistance in human colon carcinoma HT-29 cells exposed to a sublethal dose of adriamycin.
Japanese journal of cancer research : Gann 1995;86(2):224-32.
1995: K Noguchi; M Nakajima; M Naito; Takashi Tsuruo
Inhibition by differentiation-inducing agents of wild-type p53-dependent apoptosis in HL-60 cells.
Japanese journal of cancer research : Gann 1995;86(2):217-23.
1995: K Yusa; T Oh-hara; Takashi Tsuruo
Induction of resistance to 1-beta-D-arabinofuranosylcytosine in human H9 cell line by simian immunodeficiency virus.
Biochemical and biophysical research communications 1995;206(2):486-91.
1995: J Yun; Akihiro Tomida; K Nagata; Takashi Tsuruo
Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II.
Oncology research 1995;7(12):583-90.
1995: J Dong; M Naito; T Tatsuta; Hiroyuki Seimiya; O Johdo; Takashi Tsuruo
Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines.
Oncology research 1995;7(5):245-52.
1995: W Sato; N Fukazawa; O Nakanishi; M Baba; T Suzuki; O Yano; M Naito; Takashi Tsuruo
Reversal of multidrug resistance by a novel quinoline derivative, MS-209.
Cancer chemotherapy and pharmacology 1995;35(4):271-7.
1995: M Baba; O Nakanishi; W Sato; A Saito; Y Miyama; O Yano; S Shimada; N Fukazawa; M Naito; Takashi Tsuruo
Relationship between multidrug resistant gene expression and multidrug resistant-reversing effect of MS-209 in various tumor cells.
Cancer chemotherapy and pharmacology 1995;36(5):361-7.
1995: M Naito; Takashi Tsuruo
Reconstitution of purified P-glycoprotein into liposomes.
Journal of cancer research and clinical oncology 1995;121(9-10):582-6.
1994: Takashi Tsuruo; M Inaba; T Tashiro; T Yamori; Y Ohnishi; T Ashizawa; T Sakai; S Kobayashi; K Gomi
Evaluation of antitumor activity of navelbine (vinorelbine ditartrate) against human breast carcinoma xenografts based on its pharmacokinetics in nude mice.
Anti-cancer drugs 1994;5(6):634-40.
1994: M Kamishohara; H Kawai; A Odagawa; Toshiyuki Isoe; J Mochizuki; T Uchida; Y Hayakawa; H Seto; Takashi Tsuruo; N Otake
Antitumor activity of SPM VIII, a derivative of the nucleoside antibiotic spicamycin, against human tumor xenografts.
The Journal of antibiotics 1994;47(11):1305-11.
1994: S Kataoka; M Naito; Akihiro Tomida; Takashi Tsuruo
Resistance to antitumor agent-induced apoptosis in a mutant of human myeloid leukemia U937 cells.
Experimental cell research 1994;215(1):199-205.
1994: T Tatsuta; M Naito; K Mikami; Takashi Tsuruo
Enhanced expression by the brain matrix of P-glycoprotein in brain capillary endothelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(10):1145-52.
1994: K Yusa; T Oh-hara; S Tsukahara; K Baba; M Taniguchi; M Kozawa; S Takeuchi; H Hara; Takashi Tsuruo
Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by daphnodorins.
Antiviral research 1994;25(1):57-66.
1994: A Shirai; M Naito; T Tatsuta; J Dong; K Hanaoka; K Mikami; T Oh-hara; Takashi Tsuruo
Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein.
Biochimica et biophysica acta 1994;1222(3):400-4.
1994: Takashi Tsuruo
[MDR reversing drugs for clinical development].
Gan to kagaku ryoho. Cancer & chemotherapy 1994;21(7):962-7.
1994: J H Lee; M Naito; Takashi Tsuruo
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Cancer research 1994;54(9):2398-403.
1994: M Naito; Takashi Tsuruo
[Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16, and their synergistic modulation of multidrug resistance].
Gan to kagaku ryoho. Cancer & chemotherapy 1994;21(3):395-402.
1994: Seiji Yano; Saburo Sone; Yasuhiko Nishioka; M Naito; Takashi Tsuruo; T Ogura
Cyclosporin A enhances susceptibility of multi-drug resistant human cancer cells to anti-P-glycoprotein antibody-dependent cytotoxicity of monocytes, but not of lymphocytes.
Japanese journal of cancer research : Gann 1994;85(2):194-203.
1994: Takashi Tsuruo; Naoya Fujita; S Kataoka
Apoptosis of T lymphoma cells and its inhibition by monoclonal antibodies against cell surface adhesion molecules.
Princess Takamatsu symposia 1994;24():91-8.
1994: M Kamishohara; H Kawai; T Sakai; Toshiyuki Isoe; K Hasegawa; J Mochizuki; T Uchida; S Kataoka; H Yamaki; Takashi Tsuruo
Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells.
Oncology research 1994;6(8):383-90.
1993: M Nakajima; D R Welch; D M Wynn; Takashi Tsuruo; G L Nicolson
Serum and plasma M(r) 92,000 progelatinase levels correlate with spontaneous metastasis of rat 13762NF mammary adenocarcinoma.
Cancer research 1993;53(23):5802-7.
1993: Hiroyuki Seimiya; Takashi Tsuruo
Differential expression of protein tyrosine phosphatase genes during phorbol ester-induced differentiation of human leukemia U937 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(12):1033-9.
1993: T Iwahashi; E Okochi; K Ariyoshi; H Watabe; E Amann; S Mori; Takashi Tsuruo; K Ono
Specific targeting and killing activities of anti-P-glycoprotein monoclonal antibody MRK16 directed against intrinsically multidrug-resistant human colorectal carcinoma cell lines in the nude mouse model.
Cancer research 1993;53(22):5475-82.
1993: Naoya Fujita; S Kataoka; M Naito; Y Heike; N Boku; M Nakajima; Takashi Tsuruo
Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell surface adhesion molecules.
Cancer research 1993;53(20):5022-7.
1993: M Kamishohara; H Kawai; A Odagawa; Toshiyuki Isoe; J Mochizuki; T Uchida; Y Hayakawa; H Seto; Takashi Tsuruo; N Otake
Structure-antitumor activity relationship of semi-synthetic spicamycin analogues.
The Journal of antibiotics 1993;46(9):1439-46.
1993: S Kataoka; M Naito; N Fujita; H Ishii; S Ishii; T Yamori; M Nakajima; Takashi Tsuruo
Control of apoptosis and growth of malignant T lymphoma cells by lymph node stromal cells.
Experimental cell research 1993;207(2):271-6.
1993: Y Heike; Saburo Sone; Seiji Yano; Hiroyuki Seimiya; Takashi Tsuruo; T Ogura
M-CSF gene transduction in multidrug-resistant human cancer cells to enhance anti-P-glycoprotein antibody-dependent macrophage-mediated cytotoxicity.
International journal of cancer. Journal international du cancer 1993;54(5):851-7.
1993: S Ishii; M Naito; Takashi Tsuruo
Expression behavior of 85-kDa membrane protein in adriamycin-resistant tumor cells and the inhibition of human tumor growth in athymic mice by MRK-20 monoclonal antibody against the protein.
Japanese journal of cancer research : Gann 1993;84(7):776-82.
1993: T Tatsuta; Takashi Tsuruo
[Functional involvement of P-glycoprotein in blood-brain barrier].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(9):1501-9.
1993: Y Sugimoto; H Hamada; S Tsukahara; K Noguchi; K Yamaguchi; M Sato; Takashi Tsuruo
Molecular cloning and characterization of the complementary DNA for the M(r) 85,000 protein overexpressed in adriamycin-resistant human tumor cells.
Cancer research 1993;53(11):2538-43.
1993: M Naito; H Tsuge; C Kuroko; Akihiro Tomida; Takashi Tsuruo
Enhancement of reversing effect of cyclosporin A on vincristine resistance by anti-P-glycoprotein monoclonal antibody MRK-16.
Japanese journal of cancer research : Gann 1993;84(5):489-92.
1993: K Noguchi; M Naito; K Tezuka; Satoshi Ishii; Hiroyuki Seimiya; Y Sugimoto; E Amann; Takashi Tsuruo
cDNA expression cloning of the 85-kDa protein overexpressed in adriamycin-resistant cells.
Biochemical and biophysical research communications 1993;192(1):88-95.
1993: Takashi Tsuruo; T Oh-Hara; Y Sudo; M Naito
Antitumor activity of idarubicin, a derivative of daunorubicin, against drug sensitive and resistant P388 leukemia.
Anticancer research 1993;13(2):357-61.
1993: T Takatori; M Ogura; Takashi Tsuruo
Purification and characterization of NF-R2 that regulates the expression of the human multidrug resistance (MDR1) gene.
Japanese journal of cancer research : Gann 1993;84(3):298-303.
1993: M Naito; H Tsuge; C Kuroko; T Koyama; Akihiro Tomida; T Tatsuta; Y Heike; Takashi Tsuruo
Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance.
Journal of the National Cancer Institute 1993;85(4):311-6.
1993: S Kataoka; N Fujita; Takashi Tsuruo
[Apoptosis, adhesion and growth factor of malignant T lymphoma cells].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(2):134-40.
1993: N Fujita; S Kataoka; Takashi Tsuruo
[Lymphatic metastasis and cell adhesion, growth and growth inhibition].
Gan to kagaku ryoho. Cancer & chemotherapy 1993;20(3):399-404.
1993: M Nakajima; K Gohji; A Fabra; I A Fidler; Takashi Tsuruo
[Regulation of tumor metastasis and extracellular matrix degradative enzyme production by microenvironments].
Gan to kagaku ryoho. Cancer & chemotherapy 1993;20(3):380-6.
1993: S Ishii; Y Satoh; Takashi Tsuruo
Antitumor activity and cytotoxicity of a new ankinomycin derivative, 3'-,11-dibutyryl ankinomycin.
Cancer chemotherapy and pharmacology 1993;32(3):173-8.
1993: J H Lee; M Naito; M Nakajima; Takashi Tsuruo
Isolation and characterization of a mitomycin C-resistant variant of human colon carcinoma HT-29 cells.
Cancer chemotherapy and pharmacology 1993;33(3):215-20.
1992: T Tatsuta; M Naito; T Oh-hara; I Sugawara; Takashi Tsuruo
Functional involvement of P-glycoprotein in blood-brain barrier.
The Journal of biological chemistry 1992;267(28):20383-91.
1992: T Isoe; M Naito; A Shirai; R Hirai; Takashi Tsuruo
Inhibition of different steps of the ubiquitin system by cisplatin and aclarubicin.
Biochimica et biophysica acta 1992;1117(2):131-5.
1992: K Yusa; T Oh-hara; S Tsukahara; Takashi Tsuruo
Human immunodeficiency virus type 1 induces 1-beta-D-arabinofuranosylcytosine resistance in human H9 cell line.
The Journal of biological chemistry 1992;267(24):16848-50.
1992: Yasuhiko Nishioka; Saburo Sone; Y Heike; H Hamada; K Ariyoshi; Takashi Tsuruo; T Ogura
Effector cell analysis of human multidrug-resistant cell killing by mouse-human chimeric antibody against P-glycoprotein.
Japanese journal of cancer research : Gann 1992;83(6):644-9.
1992: M Naito; Takashi Tsuruo
Functionally active homodimer of P-glycoprotein in multidrug-resistant tumor cells.
Biochemical and biophysical research communications 1992;185(1):284-90.
1992: N Katagiri; M Nomura; H Sato; C Kaneko; K Yusa; Takashi Tsuruo
Synthesis and anti-HIV activity of 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine.
Journal of medicinal chemistry 1992;35(10):1882-6.
1992: H Yamaki; Mitsuko Yamaguchi; Takashi Tsuruo; H Yamaguchi
Mechanism of action of an antifungal antibiotic, RI-331, (S) 2-amino-4-oxo-5-hydroxypentanoic acid; kinetics of inactivation of homoserine dehydrogenase from Saccharomyces cerevisiae.
The Journal of antibiotics 1992;45(5):750-5.
1992: K Ariyoshi; H Hamada; M Naito; Y Heike; Hiroyuki Seimiya; K Maezawa; Takashi Tsuruo
Mouse-human chimeric antibody MH171 against the multidrug transporter P-glycoprotein.
Japanese journal of cancer research : Gann 1992;83(5):515-21.
1992: N Katagiri; T Shiraishi; H Sato; A Toyota; C Kaneko; K Yusa; T Oh-hara; Takashi Tsuruo
Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer.
Biochemical and biophysical research communications 1992;184(1):154-9.
1992: Y Heike; K Okumura; Takashi Tsuruo
Augmentation by bispecific F(ab')2 reactive with P-glycoprotein and CD3 of cytotoxicity of human effector cells on P-glycoprotein positive human renal cancer cells.
Japanese journal of cancer research : Gann 1992;83(4):366-72.
1992: S Ishii; M Naito; M Masuda; Takashi Tsuruo
Expression of 85-kDa protein of adriamycin-resistant tumor cells during hematopoietic differentiation of THP-1 and HEL cells.
Japanese journal of cancer research : Gann 1992;83(1):107-12.
1992: M Naito; T Oh-hara; A Yamazaki; T Danki; Takashi Tsuruo
Reversal of multidrug resistance by an immunosuppressive agent FK-506.
Cancer chemotherapy and pharmacology 1992;29(3):195-200.
1991: T Yamori; Y Iizuka; Y Takayama; S Nishiya; S Iwashita; A Yamazaki; T Takatori; Takashi Tsuruo
Insulin-like growth factor I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metastatic mouse colon carcinoma 26 NL-17 cells.
Cancer research 1991;51(21):5859-65.
1991: M Ogura; T Takatori; Y Sugimoto; Takashi Tsuruo
Identification and characterization of three DNA-binding proteins on the promoter of the human MDR1 gene in drug-sensitive and -resistant cells.
Japanese journal of cancer research : Gann 1991;82(10):1151-9.
1991: T Isoe; M Naito; R Hirai; Takashi Tsuruo
Inhibition of ubiquitin-ATP-dependent proteolysis and ubiquitination by cisplatin.
Anticancer research 1991;11(5):1905-9.
1991: T Iwahashi; E Okochi; K Ono; I Sugawara; Takashi Tsuruo; S Mori
Establishment of multidrug resistant human colorectal carcinoma HCT-15 cell lines and their properties.
Anticancer research 1991;11(3):1309-12.
1991: W Sato; N Fukazawa; T Suzuki; K Yusa; Takashi Tsuruo
Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073.
Cancer research 1991;51(9):2420-4.
1991: Y Sugimoto; M Watanabe; T Oh-hara; S Sato; T Isoe; Takashi Tsuruo
Suppression of experimental lung colonization of a metastatic variant of murine colon adenocarcinoma 26 by a monoclonal antibody 8F11 inhibiting tumor cell-induced platelet aggregation.
Cancer research 1991;51(3):921-5.
1991: K Tomioka; T Ishiguro; H Mizuguchi; N Komeshima; K Koga; S Tsukagoshi; Takashi Tsuruo; T Tashiro; S Tanida; T Kishi
Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues.
Journal of medicinal chemistry 1991;34(1):54-7.
1991: M Watanabe; N Komeshima; M Naito; Toshiyuki Isoe; N Otake; Takashi Tsuruo
Cellular pharmacology of MX2, a new morpholino anthracycline, in human pleiotropic drug-resistant cells.
Cancer research 1991;51(1):157-61.
1990: W Sato; K Yusa; M Naito; Takashi Tsuruo
Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells.
Biochemical and biophysical research communications 1990;173(3):1252-7.
1990: Y Sugimoto; S Tsukahara; T Oh-hara; L F Liu; Takashi Tsuruo
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.
Cancer research 1990;50(24):7962-5.
1990: Takashi Tsuruo
[Cancer metastasis and platelet aggregation].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(15):2818-24.
1990: Y Sugimoto; S Tsukahara; T Oh-hara; T Isoe; Takashi Tsuruo
Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.
Cancer research 1990;50(21):6925-30.
1990: Y Heike; H Hamada; N Inamura; Saburo Sone; T Ogura; Takashi Tsuruo
Monoclonal anti-P-glycoprotein antibody-dependent killing of multidrug-resistant tumor cells by human mononuclear cells.
Japanese journal of cancer research : Gann 1990;81(11):1155-61.
1990: M Watanabe; Y Sugimoto; Takashi Tsuruo
Expression of a Mr 41,000 glycoprotein associated with thrombin-independent platelet aggregation in high metastatic variants of murine B16 melanoma.
Cancer research 1990;50(20):6657-62.
1990: I Sugawara; H Hamada; Takashi Tsuruo; S Mori
Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.
Japanese journal of cancer research : Gann 1990;81(8):727-30.
1990: Y Sugimoto; T Oh-Hara; Y Heike; M Watanabe; Y Nakatsuru; T Ishikawa; Takashi Tsuruo
Establishment of highly metastatic variants of murine colon adenocarcinoma 26 under serum-free conditions.
International journal of cancer. Journal international du cancer 1990;46(1):118-24.
1990: K Yusa; T Oh-hara; A Yamazaki; S Tsukahara; W Satoh; Takashi Tsuruo
Cross-resistance to anti-HIV nucleoside analogs in multidrug-resistant human cells.
Biochemical and biophysical research communications 1990;169(3):986-90.
1990: Y Sugimoto; E Okochi; H Hamada; T Oh-hara; Takashi Tsuruo
Detection of 300-kilodalton membrane protein in adriamycin-resistant human tumor cells by a monoclonal antibody MRK18.
Biochemical and biophysical research communications 1990;169(2):686-91.
1990: H Hamada; K Miura; K Ariyoshi; Y Heike; S Sato; K Kameyama; Y Kurosawa; Takashi Tsuruo
Mouse-human chimeric antibody against the multidrug transporter P-glycoprotein.
Cancer research 1990;50(11):3167-71.
1990: Takashi Tsuruo; M Naito; R Takamori; S Tsukahara; J Yamabe-Mitsuhashi; A Yamazaki; T Oh-hara; Y Sudo; S Nakaike; T Yamagishi
A benzophenazine derivative, N-beta-dimethylaminoethyl 9-carboxy-5-hydroxy-10-methoxy-benzo[a]phenazine-6-carboxamide, as a new antitumor agent against multidrug-resistant and sensitive tumors.
Cancer chemotherapy and pharmacology 1990;26(2):83-7.
1990: Takashi Tsuruo; Y Sudo; N Asami; M Inaba; M Morimoto
Antitumor activity of a derivative of mitomycin, 7-N-[2-[[2-(gamma-L-glutamylamino)ethyl]dithio]ethyl]mitomycin C (KW-2149), against murine and human tumors and a mitomycin C-resistant tumor in vitro and in vivo.
Cancer chemotherapy and pharmacology 1990;27(2):89-93.
1990: Takashi Tsuruo
Multidrug resistance: a transport system of antitumor agents and xenobiotics.
Princess Takamatsu symposia 1990;21():241-51.
1989: I Sugawara; H Hamada; M Nakahama; S Okamoto; Takashi Tsuruo; S Mori
Further characterization of the human adrenal-derived P-glycoprotein recognized by monoclonal antibody MRK 16 reacting with only human P-glycoprotein.
Japanese journal of cancer research : Gann 1989;80(12):1199-205.
1989: Takashi Tsuruo; K Yusa; Y Sudo; R Takamori; Y Sugimoto
A fluorine-containing anthracycline (ME2303) as a new antitumor agent against murine and human tumors and their multidrug-resistant sublines.
Cancer research 1989;49(20):5537-42.
1989: Y Sugimoto; N Asami; Takashi Tsuruo
Expression of P-glycoprotein mRNA in human gastric tumors.
Japanese journal of cancer research : Gann 1989;80(10):993-9.
1989: I Sugawara; H Kodo; E Ohkochi; H Hamada; Takashi Tsuruo; S Mori
High-level expression of MRK 16 and MRK 20 murine monoclonal antibody-define proteins (170,000-180,000 P-glycoprotein and 85,000 protein) in leukaemias and malignant lymphomas.
British journal of cancer 1989;60(4):538-41.
1989: K Yusa; Takashi Tsuruo
Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.
Cancer research 1989;49(18):5002-6.
1989: N Komeshima; H Kawai; S Nakajima; M Watanabe; Takashi Tsuruo; T Takeuchi; N Otake
Role of DNA-binding in the cytotoxicity of an anthracycline, R20X2 and its morpholino analog, MX2.
The Journal of antibiotics 1989;42(9):1424-9.
1989: Takashi Tsuruo; H Hamada; S Sato; Y Heike
Inhibition of multidrug-resistant human tumor growth in athymic mice by anti-P-glycoprotein monoclonal antibodies.
Japanese journal of cancer research : Gann 1989;80(7):627-31.
1989: Takashi Tsuruo; S Sato; K Yusa
Antitumor activity of ME2303, a fluorine-containing anthracycline, against human tumors implanted in nude mice.
Japanese journal of cancer research : Gann 1989;80(7):686-9.
1989: I Sugawara; K Mizumoto; E Ohkochi; H Hamada; Takashi Tsuruo; S Mori
Immunocytochemical identification and localization of the Mr 22,000 calcium-binding protein (sorcin) in an adriamycin-resistant myelogenous leukemia cell line.
Japanese journal of cancer research : Gann 1989;80(5):469-74.
1989: H Shinoda; M Inaba; Takashi Tsuruo
In vivo circumvention of vincristine resistance in mice with P388 leukemia using a novel compound, AHC-52.
Cancer research 1989;49(7):1722-6.
1989: M Naito; Takashi Tsuruo
Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.
Cancer research 1989;49(6):1452-5.
1989: M Naito; K Yusa; Takashi Tsuruo
Steroid hormones inhibit binding of Vinca alkaloid to multidrug resistance related P-glycoprotein.
Biochemical and biophysical research communications 1989;158(3):1066-71.
1989: Takashi Tsuruo; M Watanabe; T Oh-hara
Stimulation of the growth of metastatic clones of mouse colon adenocarcinoma 26 in vitro by platelet-derived growth factor.
Japanese journal of cancer research : Gann 1989;80(2):136-40.
1989: M Koenuma; T Yamori; Takashi Tsuruo
Insulin and insulin-like growth factor 1 stimulate proliferation of metastatic variants of colon carcinoma 26.
Japanese journal of cancer research : Gann 1989;80(1):51-8.
1988: H Hamada; E Okochi; M Watanabe; T Oh-hara; Y Sugimoto; H Kawabata; Takashi Tsuruo
Mr 85,000 membrane protein specifically expressed in adriamycin-resistant human tumor cells.
Cancer research 1988;48(24 Pt 1):7082-7.
1988: M Watanabe; N Komeshima; S Nakajima; Takashi Tsuruo
MX2, a morpholino anthracycline, as a new antitumor agent against drug-sensitive and multidrug-resistant human and murine tumor cells.
Cancer research 1988;48(23):6653-7.
1988: M Watanabe; E Okochi; Y Sugimoto; Takashi Tsuruo
Identification of a platelet-aggregating factor of murine colon adenocarcinoma 26: Mr 44,000 membrane protein as determined by monoclonal antibodies.
Cancer research 1988;48(22):6411-6.
1988: I Sugawara; E Ohkochi; H Hamada; Takashi Tsuruo; S Mori
Cellular and tissue distribution of MRK20 murine monoclonal antibody-defined 85-kDa protein in adriamycin-resistant cancer cell lines.
Japanese journal of cancer research : Gann 1988;79(10):1101-10.
1988: H Hamada; Takashi Tsuruo
Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.
Cancer research 1988;48(17):4926-32.
1988: M Naito; H Hamada; Takashi Tsuruo
ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.
The Journal of biological chemistry 1988;263(24):11887-91.
1988: I Sugawara; M Nakahama; H Hamada; Takashi Tsuruo; S Mori
Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr 170,000-180,000 P-glycoprotein.
Cancer research 1988;48(16):4611-4.
1988: H Hamada; E Okochi; T Oh-hara; Takashi Tsuruo
Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies.
Cancer research 1988;48(11):3173-8.
1988: N Komeshima; Takashi Tsuruo; H Umezawa
Antitumor activity of new morpholino anthracyclines.
The Journal of antibiotics 1988;41(4):548-53.
1988: I Sugawara; I Kataoka; Y Morishita; H Hamada; Takashi Tsuruo; S Itoyama; S Mori
Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.
Cancer research 1988;48(7):1926-9.
1988: Takashi Tsuruo
Mechanisms of multidrug resistance and implications for therapy.
Japanese journal of cancer research : Gann 1988;79(3):285-96.
1988: H Hamada; Takashi Tsuruo
Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.
The Journal of biological chemistry 1988;263(3):1454-8.
1988: K Yusa; H Hamada; Takashi Tsuruo
Comparison of glutathione S-transferase activity between drug-resistant and -sensitive human tumor cells: is glutathione S-transferase associated with multidrug resistance?
Cancer chemotherapy and pharmacology 1988;22(1):17-20.
1988: Takashi Tsuruo; T Matsuzaki; M Matsushita; H Saito; T Yokokura
Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo.
Cancer chemotherapy and pharmacology 1988;21(1):71-4.
1987: Takashi Tsuruo; Y Sugimoto; H Hamada; I Roninson; M Okumura; K Adachi; Y Morishima; R Ohno
Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.
Japanese journal of cancer research : Gann 1987;78(12):1415-9.