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Marina Botto

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Liliane Fossati-Jimack; Guang Sheng Ling; Talat H Malik; Jacqueline U McDonald; Matthew C Pickering; Marta Szajna; Philip R Taylor; H Terence Cook; Andrea Cortini; Marina Botto
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
Myles J Lewis; Talat H Malik; Daniele Carassiti; H Terence Cook; Liliane Fossati-Jimack; Dorian O Haskard; Marina Botto
Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia.
Stephanie Menikou; Mitali P Patel; Matthew C Pickering; Kirsten L Rose; John O Warner; Marina Botto; Robert J Boyle
Relationship between complotype and reported severity of systemic allergic reactions to peanut.

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2013: Liliane Fossati-Jimack; Guang Sheng Ling; Talat H Malik; Jacqueline U McDonald; Matthew C Pickering; Marta Szajna; Philip R Taylor; H Terence Cook; Andrea Cortini; Marina Botto
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
PloS one 2013;8(2):e57082.
2012: Myles J Lewis; Talat H Malik; Daniele Carassiti; H Terence Cook; Liliane Fossati-Jimack; Dorian O Haskard; Marina Botto
Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia.
Arthritis and rheumatism 2012;64(8):2707-18.
2012: Stephanie Menikou; Mitali P Patel; Matthew C Pickering; Kirsten L Rose; John O Warner; Marina Botto; Robert J Boyle
Relationship between complotype and reported severity of systemic allergic reactions to peanut.
The Journal of allergy and clinical immunology 2012;129(5):1398-1401.e3.
2011: Guang-Sheng Ling; Yu-Lung Lau; Marina Botto; H Terence Cook; Fang-Ping Huang
An essential protective role of IL-10 in the immunological mechanism underlying resistance vs. susceptibility to lupus induction by dendritic cells and dying cells.
Rheumatology (Oxford, England) 2011;50(10):1773-84.
2011: Elena Goicoechea de Jorge; Paolo Macor; Danielle Paixão-Cavalcante; Kirsten L Rose; Franco Tedesco; H Terence Cook; Marina Botto; Matthew C Pickering
The development of atypical hemolytic uremic syndrome depends on complement C5.
Journal of the American Society of Nephrology : JASN 2011;22(1):137-45.
2010: Talat H Malik; Andrea Cortini; Daniele Carassiti; Joseph J Boyle; Dorian O Haskard; Marina Botto
The alternative pathway is critical for pathogenic complement activation in endotoxin- and diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice.
Circulation 2010;122(19):1948-56.
2010: Karl Bodin; Stephan Ellmerich; Melvyn C Kahan; Glenys A Tennent; Andrzej Loesch; Janet A Gilbertson; Winston L Hutchinson; Palma P Mangione; J Ruth Gallimore; David J Millar; Shane Minogue; Amar P Dhillon; Graham W Taylor; Arthur R Bradwell; Aviva Petrie; Julian D Gillmore; Vittorio Bellotti; Marina Botto; Philip N Hawkins; Mark B Pepys
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits.
Nature 2010;468(7320):93-7.
2010: Matthew C Pickering; Marina Botto
Are anti-C1q antibodies different from other SLE autoantibodies?
Nature reviews. Rheumatology 2010;6(8):490-3.
2010: Francesco Carlucci; Liliane Fossati-Jimack; Ingrid E Dumitriu; Yasin Heidari; Mark J Walport; Marta Szajna; Paramita Baruah; Oliver A Garden; H Terence Cook; Marina Botto
Identification and characterization of a lupus suppressor 129 locus on chromosome 3.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6256-65.
2010: Paramita Baruah; Elizabeth Simpson; Ingrid E Dumitriu; Katy Derbyshire; David Coe; Caroline Addey; Julian Dyson; Jian-Guo Chai; Terence Cook; Diane Scott; Marina Botto
Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance.
European journal of immunology 2010;40(6):1758-67.
2010: Puja Mehta; Penny J Norsworthy; Angela E Hall; Susan J Kelly; Mark J Walport; Marina Botto; Matthew C Pickering
SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience.
Rheumatology (Oxford, England) 2010;49(4):823-4.
2010: Francesco Carlucci; H Terence Cook; Abhilok Garg; Mark B Pepys; Marina Botto
Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis.
Arthritis and rheumatism 2010;62(1):245-9.
2009: S Vicky Tsoni; Ann M Kerrigan; Mohlopheni J Marakalala; Naren Srinivasan; Maureen Duffield; Philip R Taylor; Marina Botto; Chad Steele; Gordon D Brown
Complement C3 plays an essential role in the control of opportunistic fungal infections.
Infection and immunity 2009;77(9):3679-85.
2009: Marina Botto; Michael Kirschfink; Paolo Macor; Matthew C Pickering; Reinhard Wurzner; Francesco Tedesco
Complement in human diseases: Lessons from complement deficiencies.
Molecular immunology 2009;46(14):2774-83.
2009: Danielle Paixão-Cavalcante; Steven Hanson; Marina Botto; H Terence Cook; Matthew C Pickering
Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase.
Molecular immunology 2009;46(10):1942-50.
2009: D Paixão-Cavalcante; Marina Botto; H Terence Cook; Matthew C Pickering
Shiga toxin-2 results in renal tubular injury but not thrombotic microangiopathy in heterozygous factor H-deficient mice.
Clinical and experimental immunology 2009;155(2):339-47.
2009: Y Heidari; Liliane Fossati-Jimack; Francesco Carlucci; Mark J Walport; H Terence Cook; Marina Botto
A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice.
Genes and immunity 2009;10(1):47-55.
2008: Jose Yuste; Ashwin Sen; Lennart Truedsson; Göran Jönsson; Liang-Seah Tay; Catherine Hyams; Helen E Baxendale; Fiona Goldblatt; Marina Botto; Jeremy S Brown
Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway.
Infection and immunity 2008;76(8):3761-70.
2008: Liliane Fossati-Jimack; Josefina Cortes-Hernandez; Penny J Norsworthy; H Terence Cook; Mark J Walport; Marina Botto
Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.
Arthritis and rheumatism 2008;58(7):2131-41.
2008: Kirsten L Rose; Danielle Paixao-Cavalcante; Jennifer Fish; Anthony P Manderson; Talat H Malik; Anne Elisabeth Bygrave; Tao Lin; Steven H Sacks; Mark J Walport; H Terence Cook; Marina Botto; Matthew C Pickering
Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.
The Journal of clinical investigation 2008;118(2):608-18.
2008: Liliane Fossati-Jimack; Josefina Cortes-Hernandez; Penny J Norsworthy; Mark J Walport; H Terence Cook; Marina Botto
C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice.
Molecular immunology 2008;45(3):787-95.
2007: Jose Yuste; Marina Botto; Stephen E Bottoms; Jeremy S Brown
Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae.
PLoS pathogens 2007;3(9):1208-19.
2007: Richard J H Smith; Jessy Alexander; Paul N Barlow; Marina Botto; Thomas L Cassavant; H Terence Cook; Santiago Rodriguez de Córdoba; Gregory S Hageman; T. Sakari Jokiranta; William J Kimberling; John D Lambris; Lynne D Lanning; Vicki Levidiotis; Christoph Licht; Hans U Lutz; Seppo Meri; Matthew C Pickering; Richard J Quigg; Angelique L W M M Rops; David J Salant; Sanjeev Sethi; Joshua M Thurman; Hope F Tully; Sean P Tully; Johan Van der Vlag; Patrick D Walker; Reinhard Wurzner; Peter F Zipfel
New approaches to the treatment of dense deposit disease.
Journal of the American Society of Nephrology : JASN 2007;18(9):2447-56.
2007: Alastair L Hepburn; Irvin A Lampert; Joseph J Boyle; Donna E Horncastle; W Fai Ng; Mark Layton; Timothy J Vyse; Marina Botto; Justin C Mason
In vivo evidence for apoptosis in the bone marrow in systemic lupus erythematosus.
Annals of the rheumatic diseases 2007;66(8):1106-9.
2007: Matthew C Pickering; Elena Goicoechea de Jorge; Rubén Martinez-Barricarte; Sergio Recalde; Alfredo Garcia-Layana; Kirsten L Rose; Jill Moss; Mark J Walport; H Terence Cook; Santiago Rodriguez de Córdoba; Marina Botto
Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.
The Journal of experimental medicine 2007;204(6):1249-56.
2007: Helen Ferry; Paul Potter; Tanya L Crockford; Anastasia Nijnik; Michael R Ehrenstein; Mark J Walport; Marina Botto; Richard J Cornall
Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in c1q-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2916-22.
2007: Francesco Carlucci; Josefina Cortes-Hernandez; Liliane Fossati-Jimack; Anne Elisabeth Bygrave; Mark J Walport; Timothy J Vyse; H Terence Cook; Marina Botto
Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2352-60.
2007: Paul Potter; Karen Y Larbi; Sussan Nourshargh; Marina Botto
Efficient clearance of opsonised apoptotic cells in the absence of PECAM-1.
Molecular immunology 2007;44(6):1135-40.
2007: Vinay K Bhatia; Sheng Yun; Viola Leung; David C Grimsditch; Gregory Martin Benson; Marina Botto; Joseph J Boyle; Dorian O Haskard
Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice.
The American journal of pathology 2007;170(1):416-26.
2007: Philip R Taylor; S Vicky Tsoni; Janet A Willment; Kevin M Dennehy; Marcela Rosas; Helen Findon; Ken Haynes; Chad Steele; Marina Botto; Siamon Gordon; Gordon D Brown
Dectin-1 is required for beta-glucan recognition and control of fungal infection.
Nature immunology 2007;8(1):31-8.
2006: Anthony P Manderson; Ben J C Quah; Marina Botto; Christopher C Goodnow; Mark J Walport; Christopher R Parish
A novel mechanism for complement activation at the surface of B cells following antigen binding.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5155-62.
2006: Y Heidari; Anne Elisabeth Bygrave; Robert J Rigby; Kirsten L Rose; Mark J Walport; H Terence Cook; Timothy J Vyse; Marina Botto
Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus.
Genes and immunity 2006;7(7):592-9.
2006: Daniel Turnberg; Margarita Lewis; Jill Moss; Yuanyuan Xu; Marina Botto; H Terence Cook
Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):4094-102.
2006: M J Lewis; Marina Botto
Complement deficiencies in humans and animals: links to autoimmunity.
Autoimmunity 2006;39(5):367-78.
2006: Matthew C Pickering; Joanna Warren; Kirsten L Rose; Francesco Carlucci; Yulan Wang; Mark J Walport; H Terence Cook; Marina Botto
Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9649-54.
2006: H Terence Cook; Marina Botto
Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus.
Nature clinical practice. Rheumatology 2006;2(6):330-7.
2006: Jose Yuste; Sifot Ali; Shiranee Sriskandan; Catherine Hyams; Marina Botto; Jeremy S Brown
Roles of the alternative complement pathway and C1q during innate immunity to Streptococcus pyogenes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6112-20.
2006: S W Tas; Pierre Quartier; Marina Botto; Liliane Fossati-Jimack
Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells.
Annals of the rheumatic diseases 2006;65(2):216-21.
2006: Anthony P Manderson; Francesco Carlucci; Peter Lachmann; Robert A Lazarus; Richard J Festenstein; H Terence Cook; Mark J Walport; Marina Botto
The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus.
Arthritis research & therapy 2006;8(3):R68.
2005: Marten Trendelenburg; Liliane Fossati-Jimack; Josefina Cortes-Hernandez; Daniel Turnberg; Margarita Lewis; Shozo Izui; H Terence Cook; Marina Botto
The role of complement in cryoglobulin-induced immune complex glomerulonephritis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6909-14.
2005: Jose Yuste; Marina Botto; James C Paton; David W Holden; Jeremy S Brown
Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1813-9.
2005: Rachel M Exley; Jonathan Shaw; Eva Mowe; Yao-Hui Sun; Nicholas P West; Michael Williamson; Marina Botto; Harry Smith; Christoph M Tang
Available carbon source influences the resistance of Neisseria meningitidis against complement.
The Journal of experimental medicine 2005;201(10):1637-45.
2005: Clare R Monk; M Spachidou; F Rovis; E Leung; Marina Botto; Robert I Lechler; Oliver A Garden
MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus.
Arthritis and rheumatism 2005;52(4):1180-4.
2005: Pierre Quartier; Paul Potter; Michael R Ehrenstein; Mark J Walport; Marina Botto
Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro.
European journal of immunology 2005;35(1):252-60.
2004: Josefina Cortes-Hernandez; Liliane Fossati-Jimack; Franz Petry; Michael Loos; Shozo Izui; Mark J Walport; H Terence Cook; Marina Botto
Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice.
European journal of immunology 2004;34(12):3713-22.
2004: Daniel Turnberg; Marina Botto; Margarita Lewis; Wuding Zhou; Steven H Sacks; B Paul Morgan; Mark J Walport; H Terence Cook
CD59a deficiency exacerbates ischemia-reperfusion injury in mice.
The American journal of pathology 2004;165(3):825-32.
2004: Marten Trendelenburg; Anthony P Manderson; Liliane Fossati-Jimack; Mark J Walport; Marina Botto
Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice.
Immunology 2004;113(1):80-8.
2004: Anne Elisabeth Bygrave; Kirsten L Rose; Josefina Cortes-Hernandez; Joanna Warren; Robert J Rigby; H Terence Cook; Mark J Walport; Timothy J Vyse; Marina Botto
Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice.
PLoS biology 2004;2(8):E243.
2004: Winston L Hutchinson; Jeff Herbert; Marina Botto; Mark B Pepys
Classical and alternative pathway complement activation are not required for reactive systemic AA amyloid deposition in mice.
Immunology 2004;112(2):250-4.
2004: Penny J Norsworthy; Liliane Fossati-Jimack; Josefina Cortes-Hernandez; Philip R Taylor; Anne Elisabeth Bygrave; Richard D Thompson; Sussan Nourshargh; Mark J Walport; Marina Botto
Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3406-14.
2004: Marina Botto
Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal.
Arthritis research & therapy 2004;6(4):147-50.
2004: Anthony P Manderson; Marina Botto; Mark J Walport
The role of complement in the development of systemic lupus erythematosus.
Annual review of immunology 2004;22():431-56.
2004: Richard J Mead; Jim W Neal; Mark Raymond Griffiths; Christopher Linington; Marina Botto; Hans Lassmann; B Paul Morgan
Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis.
Laboratory investigation; a journal of technical methods and pathology 2004;84(1):21-8.
2003: Daniel Turnberg; Marina Botto; Joanna Warren; B Paul Morgan; Mark J Walport; H Terence Cook
CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice.
Journal of the American Society of Nephrology : JASN 2003;14(9):2271-9.
2003: Daniel Turnberg; Marina Botto
The regulation of the complement system: insights from genetically-engineered mice.
Molecular immunology 2003;40(2-4):145-53.
2003: Paul Potter; Josefina Cortes-Hernandez; Pierre Quartier; Marina Botto; Mark J Walport
Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3223-32.
2002: Jeremy S Brown; Tracy Hussell; Sarah M Gilliland; David W Holden; James C Paton; Michael R Ehrenstein; Mark J Walport; Marina Botto
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16969-74.
2002: Josefina Cortes-Hernandez; Liliane Fossati-Jimack; A Carugati; Paul Potter; Mark J Walport; H Terence Cook; Marina Botto
Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms.
Clinical and experimental immunology 2002;130(3):459-66.
2002: Marina Botto; Mark J Walport
C1q, autoimmunity and apoptosis.
Immunobiology 2002;205(4-5):395-406.
2002: Matthew C Pickering; H Terence Cook; Joanna Warren; Anne Elisabeth Bygrave; Jill Moss; Mark J Walport; Marina Botto
Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.
Nature genetics 2002;31(4):424-8.
2002: Samareh Azeredo da Silveira; Shuichi Kikuchi; Liliane Fossati-Jimack; Thomas Moll; Takashi Saito; Sjef Verbeek; Marina Botto; Mark J Walport; Michael Carroll; Shozo Izui
Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody.
The Journal of experimental medicine 2002;195(6):665-72.
2002: Daniel A Mitchell; Matthew C Pickering; Joanna Warren; Liliane Fossati-Jimack; Josefina Cortes-Hernandez; H Terence Cook; Marina Botto; Mark J Walport
C1q deficiency and autoimmunity: the effects of genetic background on disease expression.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2538-43.
2001: Franz Petry; Marina Botto; Rafaela Holtappels; Mark J Walport; Michael Loos
Reconstitution of the complement function in C1q-deficient (C1qa-/-) mice with wild-type bone marrow cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):4033-7.
2001: Anthony P Manderson; M C Pickering; Marina Botto; Mark J Walport; Christopher R Parish
Continual low-level activation of the classical complement pathway.
The Journal of experimental medicine 2001;194(6):747-56.
2001: Dewi S Holt; Marina Botto; Anne Elisabeth Bygrave; S Melanie Hanna; Mark J Walport; B Paul Morgan
Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria.
Blood 2001;98(2):442-9.
2001: Antony Cutler; Richard J Cornall; Helen Ferry; Anthony P Manderson; Marina Botto; Mark J Walport
Intact B cell tolerance in the absence of the first component of the classical complement pathway.
European journal of immunology 2001;31(7):2087-93.
2001: Matthew C Pickering; S Fischer; M R Lewis; Mark J Walport; Marina Botto; H Terence Cook
Ultraviolet-radiation-induced keratinocyte apoptosis in C1q-deficient mice.
The Journal of investigative dermatology 2001;117(1):52-8.
2001: Michael G Robson; H Terence Cook; Marina Botto; P R Taylor; Nathalie Busso; R Salvi; Charles D Pusey; Mark J Walport; Kevin A Davies
Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6820-8.
2001: Philip R Taylor; Elsa Seixas; Mark J Walport; Jean Langhorne; Marina Botto
Complement contributes to protective immunity against reinfection by Plasmodium chabaudi chabaudi parasites.
Infection and immunity 2001;69(6):3853-9.
2001: Julian T Nash; Philip R Taylor; Marina Botto; Penny J Norsworthy; Kevin A Davies; Mark J Walport
Immune complex processing in C1q-deficient mice.
Clinical and experimental immunology 2001;123(2):196-202.
2001: Marina Botto
Links between complement deficiency and apoptosis.
Arthritis research 2001;3(4):207-10.
2000: M Perraudeau; P R Taylor; H J Stauss; R Lindstedt; Anne Elisabeth Bygrave; Darryl Pappin; Stephan Ellmerich; A Whitten; Dinah Rahman; Benito Canas; Mark J Walport; Marina Botto; Daniel M Altmann
Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice.
European journal of immunology 2000;30(10):2871-80.
2000: Philip R Taylor; A Carugati; V A Fadok; H Terence Cook; M Andrews; M C Carroll; J S Savill; P M Henson; Marina Botto; Mark J Walport
A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo.
The Journal of experimental medicine 2000;192(3):359-66.
2000: Matthew C Pickering; Marina Botto; Philip R Taylor; Peter Lachmann; Mark J Walport
Systemic lupus erythematosus, complement deficiency, and apoptosis.
Advances in immunology 2000;76():227-324.
2000: Anne Elisabeth Bygrave; Marina Botto
Knocking out complement genes.
Methods in molecular biology (Clifton, N.J.) 2000;150():215-28.
1999: Penny J Norsworthy; E Theodoridis; Marina Botto; P Athanassiou; H Beynon; C Gordon; D Isenberg; Mark J Walport; Kevin A Davies
Overrepresentation of the Fcgamma receptor type IIA R131/R131 genotype in caucasoid systemic lupus erythematosus patients with autoantibodies to C1q and glomerulonephritis.
Arthritis and rheumatism 1999;42(9):1828-32.
1999: Penny J Norsworthy; Philip R Taylor; Mark J Walport; Marina Botto
Cloning of the mouse homolog of the 126-kDa human C1q/MBL/SP-A receptor, C1qR(p).
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(8):789-93.
1999: Maria C M Bickerstaff; Marina Botto; Winston L Hutchinson; Jeff Herbert; Glenys A Tennent; Alison Bybee; D A Mitchell; H T Cook; P J Butler; Mark J Walport; Mark B Pepys
Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity.
Nature medicine 1999;5(6):694-7.
1999: D A Mitchell; Philip R Taylor; H Terence Cook; Jill Moss; Anne Elisabeth Bygrave; Mark J Walport; Marina Botto
Cutting edge: C1q protects against the development of glomerulonephritis independently of C3 activation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5676-9.
1998: Mark J Walport; Kevin A Davies; Marina Botto
C1q and systemic lupus erythematosus.
Immunobiology 1998;199(2):265-85.
1998: A J Cutler; Marina Botto; D van Essen; R Rivi; Kevin A Davies; D Gray; Mark J Walport
T cell-dependent immune response in C1q-deficient mice: defective interferon gamma production by antigen-specific T cells.
The Journal of experimental medicine 1998;187(11):1789-97.
1998: Marina Botto; C Dell'Agnola; Anne Elisabeth Bygrave; E M Thompson; H Terence Cook; Franz Petry; Michael Loos; P P Pandolfi; Mark J Walport
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies.
Nature genetics 1998;19(1):56-9.
1998: P Taylor; Marina Botto; Mark J Walport
The complement system.
Current biology : CB 1998;8(8):R259-61.
1998: Philip R Taylor; Julian T Nash; E Theodoridis; Anne Elisabeth Bygrave; Mark J Walport; Marina Botto
A targeted disruption of the murine complement factor B gene resulting in loss of expression of three genes in close proximity, factor B, C2, and D17H6S45.
The Journal of biological chemistry 1998;273(3):1699-704.
1998: Marina Botto
C1q knock-out mice for the study of complement deficiency in autoimmune disease.
Experimental and clinical immunogenetics 1998;15(4):231-4.
1997: P R Taylor; JH Slingsby; Mark J Walport; Marina Botto
Murine D17H6S45 (Rd) gene: polymorphism and overlap with complement factor B.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(10):796-7.
1997: Marina Botto; Philip N Hawkins; Maria C M Bickerstaff; Jeff Herbert; Anne Elisabeth Bygrave; A McBride; Winston L Hutchinson; Glenys A Tennent; Mark J Walport; Mark B Pepys
Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene.
Nature medicine 1997;3(8):855-9.
1997: Mark J Walport; Kevin A Davies; Bernard J Morley; Marina Botto
Complement deficiency and autoimmunity.
Annals of the New York Academy of Sciences 1997;815():267-81.
1996: K Nason-Burchenal; D Gandini; Marina Botto; J Allopenna; J R Seale; N C Cross; J M Goldman; Ethan Dmitrovsky; Pier Paolo Pandolfi
Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line.
Blood 1996;88(10):3926-36.
1996: M A Naughton; M J Walport; Reinhard Wurzner; M J Carter; G J Alexander; J M Goldman; Marina Botto
Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humans.
European journal of immunology 1996;26(9):2108-12.
1996: Marina Botto; E Theodoridis; E M Thompson; H L Beynon; D Briggs; D A Isenberg; Mark J Walport; Kevin A Davies
Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease.
Clinical and experimental immunology 1996;104(2):264-8.
1996: M A Naughton; Marina Botto; M J Carter; G J Alexander; J M Goldman; Mark J Walport
Extrahepatic secreted complement C3 contributes to circulating C3 levels in humans.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):3051-6.
1996: Franz Petry; P J McClive; Marina Botto; Bernard J Morley; Grant Morahan; Michael Loos
The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization.
Immunogenetics 1996;43(6):370-6.
1995: Thomas Höhler; Marina Botto; Christian Rittner; Peter M Schneider; K H Meyer zum Büschenfelde
Complement component C3: molecular basis of the C3*S025 variant and evidence for molecular heterogeneity of other variants.
Human genetics 1995;96(5):539-41.
1994: Mark J Walport; Kevin A Davies; Marina Botto; M A Naughton; D A Isenberg; D Biasi; R J Powell; N T Cheung; G R Struthers
C3 nephritic factor and SLE: report of four cases and review of the literature.
QJM : monthly journal of the Association of Physicians 1994;87(10):609-15.
1992: Marina Botto; K Y Fong; Alexander Kai-Lik So; R Barlow; R Routier; Bernard J Morley; Mark J Walport
Homozygous hereditary C3 deficiency due to a partial gene deletion.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4957-61.
1990: Marina Botto; K Y Fong; Alexander Kai-Lik So; A Rudge; Mark J Walport
Molecular basis of hereditary C3 deficiency.
The Journal of clinical investigation 1990;86(4):1158-63.
1990: Marina Botto; K Y Fong; Alexander Kai-Lik So; C Koch; Mark J Walport
Molecular basis of polymorphisms of human complement component C3.
The Journal of experimental medicine 1990;172(4):1011-7.
1990: K Y Fong; Marina Botto; Mark J Walport; Alexander Kai-Lik So
Genomic organization of human complement component C3.
Genomics 1990;7(4):579-86.
1990: Marina Botto; K Y Fong; Alexander Kai-Lik So
EcoRI polymorphism in the human third complement component (C3) gene.
Nucleic acids research 1990;18(9):2833.
1990: Marina Botto; Alexander Kai-Lik So; C M Giles; PD Mason; Mark J Walport
HLA class I expression on erythrocytes and platelets from patients with systemic lupus erythematosus, rheumatoid arthritis and from normal subjects.
British journal of haematology 1990;75(1):106-11.
1990: C M Giles; Marina Botto; M J King
A study of HLA (Bg) on red cells and platelets by immunoblotting with monoclonal antibodies.
Transfusion 1990;30(2):126-32.
1989: C M Giles; C Darke; G P Rowe; Marina Botto
HLA class I (Bg) antigens on red cells of SLE patients: a serological study with polyclonal and monoclonal antibodies.
Vox sanguinis 1989;56(4):254-61.
1988: F Moldenhauer; Marina Botto; Mark J Walport
The rate of loss of CR1 from ageing erythrocytes in vivo in normal subjects and SLE patients: no correlation with structural or numerical polymorphisms.
Clinical and experimental immunology 1988;72(1):74-8.