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Shinji Tsutsumi

Research Profile

Chemicals & Drugs

Phenomena

Disorders

Neoplasms

Anatomy

Tumor Cell Line

Living Beings

Concepts & Ideas

Protein Structure, Tertiary

Procedures

Fluorescence Resonance Energy Transfer

Co-author Network

Publications

TOP 3
Soichiro Yoshida; Didier Picard; Carole Sourbier; Manabu Tatokoro; Jane Trepel; Shinji Tsutsumi; Evangelia Vartholomaiou; Wanping Xu; Kristin Beebe; Yang Chen; Hiroshi Fukushima; Hisashi Hasumi; Kazunori Kihara; Fumitaka Koga; Min-Jung Lee; Sunmin Lee; Naoto Miyajima; Robert P Mohney; Guillaume Muhlebach; Ken Nakamura; Len Neckers
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
S V Alarcon; A B Apolo; G Giaccone; Y S Kim; M-J Lee; S Lee; Mehdi Mollapour; L M Neckers; T Prince; Shinji Tsutsumi; W Xu; J B Trepel
Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.
Aki Iwai; Sandra M Jensen-Taubman; Sunmin Lee; Naoto Miyajima; Mehdi Mollapour; Armine K Smith; William G Stetler-Stevenson; David Sun; Jane B Trepel; Shinji Tsutsumi; Xiaolin Wu; Soichiro Yoshida; Brian S Blagg; Dimitra Bourboulia; Alison C Donnelly; Len Neckers
Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells.

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All Publications

2013: Soichiro Yoshida; Didier Picard; Carole Sourbier; Manabu Tatokoro; Jane Trepel; Shinji Tsutsumi; Evangelia Vartholomaiou; Wanping Xu; Kristin Beebe; Yang Chen; Hiroshi Fukushima; Hisashi Hasumi; Kazunori Kihara; Fumitaka Koga; Min-Jung Lee; Sunmin Lee; Naoto Miyajima; Robert P Mohney; Guillaume Muhlebach; Ken Nakamura; Len Neckers
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(17):E1604-12.
2012: S V Alarcon; A B Apolo; G Giaccone; Y S Kim; M-J Lee; S Lee; Mehdi Mollapour; L M Neckers; T Prince; Shinji Tsutsumi; W Xu; J B Trepel
Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.
Current molecular medicine 2012;12(9):1125-41.
2012: Aki Iwai; Sandra M Jensen-Taubman; Sunmin Lee; Naoto Miyajima; Mehdi Mollapour; Armine K Smith; William G Stetler-Stevenson; David Sun; Jane B Trepel; Shinji Tsutsumi; Xiaolin Wu; Soichiro Yoshida; Brian S Blagg; Dimitra Bourboulia; Alison C Donnelly; Len Neckers
Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells.
Cell cycle (Georgetown, Tex.) 2012;11(19):3649-55.
2012: Shinji Tsutsumi; Soichiro Yoshida; Barry Panaretou; Chrisostomos Prodromou; Chung-Tien Lee; Matthias P Mayer; Mehdi Mollapour; Leonard M Neckers
Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2937-42.
2011: Mehdi Mollapour; Jane Trepel; Shinji Tsutsumi; Yeong Sang Kim; Len Neckers
Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity.
Oncotarget 2011;2(5):407-17.
2011: Mehdi Mollapour; Shinji Tsutsumi; Andrew Truman; Wanping Xu; Cara K Vaughan; Kristin Beebe; Anna Konstantinova; Srinivas Vourganti; Barry Panaretou; Peter W Piper; Jane Trepel; Chrisostomos Prodromou; Laurence H Pearl; Len Neckers
Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity.
Molecular cell 2011;41(6):672-81.
2010: Mehdi Mollapour; Shinji Tsutsumi; Len Neckers
Hsp90 phosphorylation, Wee1 and the cell cycle.
Cell cycle (Georgetown, Tex.) 2010;9(12):2310-6.
2010: Mehdi Mollapour; Shinji Tsutsumi; Alison C Donnelly; Kristin Beebe; Mari J Tokita; Min-Jung Lee; Sunmin Lee; Giulia Morra; Dimitra Bourboulia; Bradley T Scroggins; Giorgio Colombo; Brian S Blagg; Barry Panaretou; William Stetler-Stevenson; Jane Trepel; Peter W Piper; Chrisostomos Prodromou; Laurence H Pearl; Len Neckers
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.
Molecular cell 2010;37(3):333-43.
2009: Shinji Tsutsumi; Mehdi Mollapour; Christian Graf; Chung-Tien Lee; Bradley T Scroggins; Wanping Xu; Lenka Haslerova; Martin Hessling; Anna A Konstantinova; Jane Trepel; Barry Panaretou; Johannes Buchner; Matthias P Mayer; Chrisostomos Prodromou; Len Neckers
Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain.
Nature structural & molecular biology 2009;16(11):1141-7.
2009: Suiquan Wang; Itai Pashtan; Shinji Tsutsumi; Wanping Xu; Len Neckers
Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors.
Cell cycle (Georgetown, Tex.) 2009;8(13):2050-6.
2009: Shinji Tsutsumi; Kristin Beebe; Len Neckers
Impact of heat-shock protein 90 on cancer metastasis.
Future oncology (London, England) 2009;5(5):679-88.
2009: Len Neckers; Mehdi Mollapour; Shinji Tsutsumi
The complex dance of the molecular chaperone Hsp90.
Trends in biochemical sciences 2009;34(5):223-6.
2009: Len Neckers; Shinji Tsutsumi; Mehdi Mollapour
Visualizing the twists and turns of a molecular chaperone.
Nature structural & molecular biology 2009;16(3):235-6.
2008: Akihiro Yano; Shinji Tsutsumi; Shiro Soga; Min-Jung Lee; Jane Trepel; Hiroyuki Osada; Len Neckers
Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15541-6.
2008: Shinji Tsutsumi; B Scroggins; F Koga; Mao-Jung Lee; Jane Trepel; Sara J Felts; C Carreras; Len Neckers
A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion.
Oncogene 2008;27(17):2478-87.
2007: Len Neckers; Adam Kern; Shinji Tsutsumi
Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells.
Chemistry & biology 2007;14(11):1204-6.
2007: Shinji Tsutsumi; Len Neckers
Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis.
Cancer science 2007;98(10):1536-9.
2007: Fumitaka Koga; Shinji Tsutsumi; Leonard M Neckers
Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells.
Cell cycle (Georgetown, Tex.) 2007;6(11):1393-402.
2007: Bradley T Scroggins; Kenneth Robzyk; Dongxia Wang; Monica G Marcu; Shinji Tsutsumi; Kristin Beebe; Robert J Cotter; Sara J Felts; David O Toft; Larry M Karnitz; Neal Rosen; Len Neckers
An acetylation site in the middle domain of Hsp90 regulates chaperone function.
Molecular cell 2007;25(1):151-9.