FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Tiziano Tuccinardi

Research Profile

Concepts & Ideas

Chemicals & Drugs

Occupations

Drug Design

Activities & Behaviors

Computer Simulation

Genes & Molecular Sequences

Procedures

Phenomena

Protein Binding

Physiology

Binding, Competitive

Co-author Network

Publications

TOP 3
Tiziano Tuccinardi; Simone Bertini; Carlotta Granchi; Marco Macchia; Adriano Martinelli; Filippo Minutolo; Gabriella Ortore; Claudiu T Supuran
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.
Anna Maria Malfitano; Clementina Manera; Giuseppe Matarese; Claudio Procaccini; Giuseppe Saccomanni; Tiziano Tuccinardi; Alba D'Alessandro; Patrizia Gazzerro; Chiara Laezza; Marco Macchia; Maurizio Bifulco
Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis.
Chun-Ho Wong; Anne M Baranger; Yen-Jun Ho; Alex M H Lucas; Stacie L Richardson; Tiziano Tuccinardi; Steven C Zimmerman
Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Tiziano Tuccinardi (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Tiziano Tuccinardi; Simone Bertini; Carlotta Granchi; Marco Macchia; Adriano Martinelli; Filippo Minutolo; Gabriella Ortore; Claudiu T Supuran
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.
Bioorganic & medicinal chemistry 2013;21(6):1511-5.
2013: Anna Maria Malfitano; Clementina Manera; Giuseppe Matarese; Claudio Procaccini; Giuseppe Saccomanni; Tiziano Tuccinardi; Alba D'Alessandro; Patrizia Gazzerro; Chiara Laezza; Marco Macchia; Maurizio Bifulco
Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis.
PloS one 2013;8(5):e62511.
2012: Chun-Ho Wong; Anne M Baranger; Yen-Jun Ho; Alex M H Lucas; Stacie L Richardson; Tiziano Tuccinardi; Steven C Zimmerman
Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.
Chembiochem : a European journal of chemical biology 2012;13(17):2505-9.
2012: Clementina Manera; Flavio Rizzolio; Giuseppe Saccomanni; Tiziano Tuccinardi; Simone Bertini; Maurizio Bifulco; Francesca Castelli; Vincenzo Di Marzo; Antonio Giordano; Chiara Laezza; Alessia Ligresti; Valentina Lucchesi; Marco Macchia; Anna Maria Malfitano; Adriano Martinelli
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.
European journal of medicinal chemistry 2012;52():284-94.
2012: Gabriella Ortore; Tiziano Tuccinardi; Adriano Martinelli
Computational studies on translocator protein (TSPO) and its ligands.
Current topics in medicinal chemistry 2012;12(4):352-9.
2011: Carlotta Granchi; Mario Lanza; Antonio Lucacchini; Marco Macchia; Adriano Martinelli; Marco Mottinelli; Elisa Nardini; Sarabindu Roy; Tiziano Tuccinardi; Laura Betti; Fabio Campinoti; Gino Giannaccini; Filippo Minutolo
Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5.
Bioorganic & medicinal chemistry letters 2011;21(24):7331-6.
2011: Carlotta Granchi; Mario Lanza; Antonio Lucacchini; Marco Macchia; Adriano Martinelli; Laura Betti; Alessio De Simone; Gino Giannaccini; Elisa Giovannetti; Godefridus J Peters; Sarabindu Roy; Irene Salvetti; Rocco Sciarrillo; Tiziano Tuccinardi; Filippo Minutolo
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation.
European journal of medicinal chemistry 2011;46(11):5398-407.
2011: Eva Anna Enyedy; Christian G. Hartinger; Anasztázia Hetényi; László Horváth; Bernhard K Keppler; Tiziano Tuccinardi; Tamás Kiss
Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies.
Bioorganic & medicinal chemistry 2011;19(14):4202-10.
2011: Tiziano Tuccinardi; Zizzari Alessandra Tania; Chiara Brullo; Simona Daniele; Gianluca Giorgi; Adriano Martinelli; Claudia Martini; Francesca Musumeci; Silvia Schenone; Maria Letizia Trincavelli; Maurizio Botta
Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: developments in understanding the receptor stereoselectivity.
Organic & biomolecular chemistry 2011;9(12):4448-55.
2011: Simone Bertini; Andrea De Cupertinis; Carlotta Granchi; Barbara Bargagli; Tiziano Tuccinardi; Adriano Martinelli; Marco Macchia; Jillian Rebecca Gunther; Kathryn E Carlson; John A Katzenellenbogen; Filippo Minutolo
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.
European journal of medicinal chemistry 2011;46(6):2453-62.
2011: Tiziano Tuccinardi
Binding-interaction prediction of RNA-binding ligands.
Future medicinal chemistry 2011;3(6):723-33.
2011: Carlotta Granchi; Sarabindu Roy; Chiara Giacomelli; Marco Macchia; Tiziano Tuccinardi; Adriano Martinelli; Mario Lanza; Laura Betti; Gino Giannaccini; Antonio Lucacchini; Nicola Funel; Leticia G León; Elisa Giovannetti; Godefridus J Peters; Rahul Palchaudhuri; Emilia C Calvaresi; Paul J Hergenrother; Filippo Minutolo
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
Journal of medicinal chemistry 2011;54(6):1599-612.
2010: Gabriella Ortore; Tiziano Tuccinardi; Elisabetta Orlandini; Adriano Martinelli
Different binding modes of structurally diverse ligands for human D3DAR.
Journal of chemical information and modeling 2010;50(12):2162-75.
2010: Simone Bertini; Vincenzo Calderone; Isabella Carboni; Roberta Maffei; Alma Martelli; Adriano Martinelli; Filippo Minutolo; Mehdi Rajabi; Lara Testai; Tiziano Tuccinardi; Riccardo Ghidoni; Marco Macchia
Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties.
Bioorganic & medicinal chemistry 2010;18(18):6715-24.
2010: Sílvia Chaves; Sérgio M Marques; André M F Matos; Andreia Nunes; Lurdes Gano; Tiziano Tuccinardi; Adriano Martinelli; M Amélia Santos
New tris(hydroxypyridinones) as iron and aluminium sequestering agents: synthesis, complexation and in vivo studies.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(34):10535-45.
2010: Tiziano Tuccinardi; Maurizio Botta; Antonio Giordano; Adriano Martinelli
Protein kinases: docking and homology modeling reliability.
Journal of chemical information and modeling 2010;50(8):1432-41.
2010: Flavio Rizzolio; Tiziano Tuccinardi; Isabella Caligiuri; Chiara Lucchetti; Antonio Giordano
CDK inhibitors: from the bench to clinical trials.
Current drug targets 2010;11(3):279-90.
2010: Tiziano Tuccinardi; Adriano Martinelli
Adenosine receptor ligands: where are we, and where are we going?
Current topics in medicinal chemistry 2010;10(10):941.
2010: Tiziano Tuccinardi; Adriano Martinelli
Adenosine receptor ligands: where are we, and where are we going?
Current topics in medicinal chemistry 2010;10(9):859.
2010: Flavio Rizzolio; Raffaele La Montagna; Tiziano Tuccinardi; Giuseppe Russo; Mario Caputi; Antonio Giordano
Adenosine receptor ligands in clinical trials.
Current topics in medicinal chemistry 2010;10(10):1036-45.
2009: Elisa Nuti; Laura Panelli; Francesca Casalini; Stanislava I Avramova; Elisabetta Orlandini; Salvatore Santamaria; Susanna Nencetti; Tiziano Tuccinardi; Adriano Martinelli; Giovanni Cercignani; Nicola D'Amelio; Alessandro Maiocchi; Fulvio Uggeri; Armando Rossello
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.
Journal of medicinal chemistry 2009;52(20):6347-61.
2009: Tiziano Tuccinardi; Sabrina Taliani; Marusca Bellandi; Federico Da Settimo; Eleonora Da Pozzo; Claudia Martini; Adriano Martinelli
A virtual screening study of the 18 kDa translocator protein using pharmacophore models combined with 3D-QSAR studies.
ChemMedChem 2009;4(10):1686-94.
2009: Elisa Nuti; Francesca Casalini; Stanislava I Avramova; Salvatore Santamaria; Giovanni Cercignani; Luciana Marinelli; Valeria La Pietra; Ettore Novellino; Elisabetta Orlandini; Susanna Nencetti; Tiziano Tuccinardi; Adriano Martinelli; Ngee-Han Lim; Robert Visse; Hideaki Nagase; Armando Rossello
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Journal of medicinal chemistry 2009;52(15):4757-73.
2009: Tiziano Tuccinardi; Gabriella Ortore; M Amélia Santos; Sérgio M Marques; Elisa Nuti; Armando Rossello; Adriano Martinelli
Multitemplate alignment method for the development of a reliable 3D-QSAR model for the analysis of MMP3 inhibitors.
Journal of chemical information and modeling 2009;49(7):1715-24.
2009: Clementina Manera; Giuseppe Saccomanni; Barbara Adinolfi; Veronica Benetti; Alessia Ligresti; Maria Grazia Cascio; Tiziano Tuccinardi; Valentina Lucchesi; Adriano Martinelli; Paola Nieri; Emanuela Masini; Vincenzo Di Marzo; Pier Luigi Ferrarini
Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.
Journal of medicinal chemistry 2009;52(12):3644-51.
2009: Antonella Brizzi; Vittorio Brizzi; Maria Grazia Cascio; Federico Corelli; Francesca Guida; Alessia Ligresti; Sabatino Maione; Adriano Martinelli; Serena Pasquini; Tiziano Tuccinardi; Vincenzo Di Marzo
New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo.
Journal of medicinal chemistry 2009;52(8):2506-14.
2009: Tiziano Tuccinardi
Docking-based virtual screening: recent developments.
Combinatorial chemistry & high throughput screening 2009;12(3):303-14.
2009: Concettina La Motta; Stefania Sartini; Tiziano Tuccinardi; Erika Nerini; Federico Da Settimo; Adriano Martinelli
Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship analysis, and virtual screening studies.
Journal of medicinal chemistry 2009;52(4):964-75.
2009: Filippo Minutolo; Simone Bertini; Carlotta Granchi; Teresa Marchitiello; Giovanni Prota; Simona Rapposelli; Tiziano Tuccinardi; Adriano Martinelli; Jillian Rebecca Gunther; Kathryn E Carlson; John A Katzenellenbogen; Marco Macchia
Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta.
Journal of medicinal chemistry 2009;52(3):858-67.
2008: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; LUISA-CARLOTA LÓPEZ-CARA; Giulia Saponaro; Stefania Baraldi; Maurizio Botta; Cesare Bernardini; Andrea Tafi; Tiziano Tuccinardi; Adriano Martinelli; Katia Varani; Pier Andrea Borea
Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(24):10281-94.
2008: Tiziano Tuccinardi; Elisa Nuti; Gabriella Ortore; Armando Rossello; Stanislava I Avramova; Adriano Martinelli
Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors.
Bioorganic & medicinal chemistry 2008;16(16):7749-58.
2008: Tiziano Tuccinardi; Silvia Schenone; Francesco Bondavalli; Chiara Brullo; Olga Bruno; Luisa Mosti; Zizzari Alessandra Tania; Cristina Tintori; Fabrizio Manetti; Osele Ciampi; Maria Letizia Trincavelli; Claudia Martini; Adriano Martinelli; Maurizio Botta
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model.
ChemMedChem 2008;3(6):898-913.
2008: Clementina Manera; Tiziano Tuccinardi; Adriano Martinelli
Indoles and related compounds as cannabinoid ligands.
Mini reviews in medicinal chemistry 2008;8(4):370-87.
2008: Barbara Cosimelli; Giovanni Greco; Marina Ehlardo; Ettore Novellino; Federico Da Settimo; Sabrina Taliani; Concettina La Motta; Marusca Bellandi; Tiziano Tuccinardi; Adriano Martinelli; Osele Ciampi; Maria Letizia Trincavelli; Claudia Martini
Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2008;51(6):1764-70.
2008: Filippo Minutolo; R Bellini; Simone Bertini; Isabella Carboni; Annalina Lapucci; Letizia Pistolesi; Giovanni Prota; Simona Rapposelli; Francesca Solati; Tiziano Tuccinardi; Adriano Martinelli; Fabio Stossi; Kathryn E Carlson; Benita S Katzenellenbogen; John A Katzenellenbogen; Marco Macchia
Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta.
Journal of medicinal chemistry 2008;51(5):1344-51.
2008: Adriano Martinelli; Tiziano Tuccinardi
Molecular modeling of adenosine receptors: new results and trends.
Medicinal research reviews 2008;28(2):247-77.
2007: Clementina Manera; Maria Grazia Cascio; Veronica Benetti; Marco Allarà; Tiziano Tuccinardi; Adriano Martinelli; Giuseppe Saccomanni; Elisa Vivoli; Carla Ghelardini; Vincenzo Di Marzo; Pier Luigi Ferrarini
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.
Bioorganic & medicinal chemistry letters 2007;17(23):6505-10.
2007: Federico Da Settimo; Giampaolo Primofiore; Sabrina Taliani; Anna Maria Marini; Concettina La Motta; Francesca Simorini; Silvia Salerno; Valentina Sergianni; Tiziano Tuccinardi; Adriano Martinelli; Barbara Cosimelli; Giovanni Greco; Ettore Novellino; Osele Ciampi; Maria Letizia Trincavelli; Claudia Martini
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2007;50(23):5676-84.
2007: Tiziano Tuccinardi; Gabriella Ortore; Armando Rossello; Claudiu T Supuran; Adriano Martinelli
Homology modeling and receptor-based 3D-QSAR study of carbonic anhydrase IX.
Journal of chemical information and modeling 2007;47(6):2253-62.
2007: Antonella Brizzi; Maria Grazia Cascio; Vittorio Brizzi; Tiziana Bisogno; Maria Teresa Dinatolo; Adriano Martinelli; Tiziano Tuccinardi; Vincenzo Di Marzo
Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.
Bioorganic & medicinal chemistry 2007;15(16):5406-16.
2007: Tiziano Tuccinardi; Elisa Nuti; Gabriella Ortore; Claudiu T Supuran; Armando Rossello; Adriano Martinelli
Analysis of human carbonic anhydrase II: docking reliability and receptor-based 3D-QSAR study.
Journal of chemical information and modeling 2007;47(2):515-25.
2007: Tiziano Tuccinardi; Fabrizio Manetti; Silvia Schenone; Adriano Martinelli; Maurizio Botta
Construction and validation of a RET TK catalytic domain by homology modeling.
Journal of chemical information and modeling 2007;47(2):644-55.
2007: Tiziano Tuccinardi; Adriano Martinelli
Computational approaches on angiotensin receptors and their ligands: recent developments and results.
Current medicinal chemistry 2007;14(29):3105-21.
2007: Elisa Nuti; Tiziano Tuccinardi; Armando Rossello
Matrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors.
Current pharmaceutical design 2007;13(20):2087-100.
2006: M Amélia Santos; Sérgio M Marques; Tiziano Tuccinardi; Paolo Carelli; Laura Panelli; Armando Rossello
Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors.
Bioorganic & medicinal chemistry 2006;14(22):7539-50.
2006: Clementina Manera; Veronica Benetti; M Paola Castelli; Tiziana Cavallini; Sara Lazzarotti; Fabio Pibiri; Giuseppe Saccomanni; Tiziano Tuccinardi; Alfredo Vannacci; Adriano Martinelli; Pier Luigi Ferrarini
Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.
Journal of medicinal chemistry 2006;49(20):5947-57.
2006: Adriano Martinelli; Tiziano Tuccinardi
An overview of recent developments in GPCR modelling: methods and validation.
Expert opinion on drug discovery 2006;1(5):459-76.
2006: Tiziano Tuccinardi; Simone Bertini; Adriano Martinelli; Filippo Minutolo; Gabriella Ortore; Giorgio Placanica; Giovanni Prota; Simona Rapposelli; Kathryn E Carlson; John A Katzenellenbogen; Marco Macchia
Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes.
Journal of medicinal chemistry 2006;49(16):5001-12.
2006: Tiziano Tuccinardi; Vincenzo Calderone; Simona Rapposelli; Adriano Martinelli
Proposal of a new binding orientation for non-peptide AT1 antagonists: homology modeling, docking and three-dimensional quantitative structure-activity relationship analysis.
Journal of medicinal chemistry 2006;49(14):4305-16.
2006: Andrea Tafi; Cesare Bernardini; Maurizio Botta; Federico Corelli; Matteo Andreini; Adriano Martinelli; Gabriella Ortore; Pier Giovanni Baraldi; Francesca Fruttarolo; Pier Andrea Borea; Tiziano Tuccinardi
Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.
Journal of medicinal chemistry 2006;49(14):4085-97.
2006: Tiziano Tuccinardi; Adriano Martinelli; Elisa Nuti; Paolo Carelli; Federica Balzano; Gloria Uccello-Barretta; Gillian Murphy; Armando Rossello
Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides.
Bioorganic & medicinal chemistry 2006;14(12):4260-76.
2006: Tiziano Tuccinardi; Gabriella Ortore; Clementina Manera; Giuseppe Saccomanni; Adriano Martinelli
Adenosine receptor modelling. A1/A2a selectivity.
European journal of medicinal chemistry 2006;41(3):321-9.
2006: Gabriella Ortore; Tiziano Tuccinardi; Simone Bertini; Adriano Martinelli
A theoretical study to investigate D2DAR/D4DAR selectivity: receptor modeling and molecular docking of dopaminergic ligands.
Journal of medicinal chemistry 2006;49(4):1397-407.
2006: Tiziano Tuccinardi; Pier Luigi Ferrarini; Clementina Manera; Gabriella Ortore; Giuseppe Saccomanni; Adriano Martinelli
Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis.
Journal of medicinal chemistry 2006;49(3):984-94.
2006: Filippo Minutolo; Simone Bertini; Laura Betti; Romano Danesi; Gianbattista Gervasi; Gino Giannaccini; Adriano Martinelli; Anna Maria Papini; Elisa Peroni; Giorgio Placanica; Simona Rapposelli; Tiziano Tuccinardi; Marco Macchia
Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition.
ChemMedChem 2006;1(2):218-24.
2005: Clementina Manera; Laura Betti; Tiziana Cavallini; Gino Giannaccini; Adriano Martinelli; Gabriella Ortore; Giuseppe Saccomanni; Letizia Trincavelli; Tiziano Tuccinardi; Pier Luigi Ferrarini
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.
Bioorganic & medicinal chemistry letters 2005;15(20):4604-10.
2005: Armando Rossello; Elisa Nuti; Maria Pia Catalani; Paolo Carelli; Elisabetta Orlandini; Simona Rapposelli; Tiziano Tuccinardi; Susan J Atkinson; Gillian Murphy; Aldo Balsamo
A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs.
Bioorganic & medicinal chemistry letters 2005;15(9):2311-4.
2004: Pier Luigi Ferrarini; Laura Betti; Tiziana Cavallini; Gino Giannaccini; Antonio Lucacchini; Clementina Manera; Adriano Martinelli; Gabriella Ortore; Giuseppe Saccomanni; Tiziano Tuccinardi
Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.
Journal of medicinal chemistry 2004;47(12):3019-31.