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Stephen Tucker

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Matthias R Schmidt; Phillip J Stansfeld; Stephen J Tucker; Mark S P Sansom
Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.
Vassiliy N Bavro; Rita De Zorzi; João R C Muniz; Mark S P Sansom; Matthias R Schmidt; Catherine Vénien-Bryan; Lejla Zubcevic; Stephen J Tucker
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.
Sebastian Leptihn; James Russell Thompson; Stephen J Tucker; J Clive Ellory; Mark I Wallace
In vitro reconstitution of eukaryotic ion channels using droplet interface bilayers.

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All Publications

2013: Matthias R Schmidt; Phillip J Stansfeld; Stephen J Tucker; Mark S P Sansom
Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.
Biochemistry 2013;52(2):279-81.
2012: Vassiliy N Bavro; Rita De Zorzi; João R C Muniz; Mark S P Sansom; Matthias R Schmidt; Catherine Vénien-Bryan; Lejla Zubcevic; Stephen J Tucker
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.
Nature structural & molecular biology 2012;19(2):158-63.
2011: Sebastian Leptihn; James Russell Thompson; Stephen J Tucker; J Clive Ellory; Mark I Wallace
In vitro reconstitution of eukaryotic ion channels using droplet interface bilayers.
Journal of the American Chemical Society 2011;133(24):9370-5.
2011: Maria Cristina D'Adamo; Lijun Shang; Paola Imbrici; Steve D M Brown; Mauro Pessia; Stephen J Tucker
Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.
The Journal of biological chemistry 2011;286(1):192-8.
2010: Jennifer J Paynter; Isabelle Andres-Enguix; Philip W Fowler; Stephen Tottey; Wayland Cheng; Decha Enkvetchakul; Vassiliy N Bavro; Yoshio Kusakabe; Mark S P Sansom; Nigel J Robinson; Colin G Nichols; Stephen J Tucker
Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.
The Journal of biological chemistry 2010;285(52):40754-61.
2010: Jennifer J Paynter; Lijun Shang; Murali K Bollepalli; Thomas Baukrowitz; Stephen J Tucker
Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.
Channels (Austin, Tex.) 2010;4(5):390-7.
2009: Lijun Shang; Sarah V Ranson; Stephen J Tucker
Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis.
Biochemical and biophysical research communications 2009;388(3):501-5.
2009: Paola Imbrici; Alessandro Grottesi; Maria Cristina D'Adamo; Roberta Mannucci; Stephen J Tucker; Mauro Pessia
Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.
Channels (Austin, Tex.) 2009;3(1):39-45.
2008: Jennifer J Paynter; Peter Sarkies; Isabelle Andres-Enguix; Stephen J Tucker
Genetic selection of activatory mutations in KcsA.
Channels (Austin, Tex.) 2008;2(6):413-8.
2008: Yasuo Nagaoka; Lijun Shang; Arijit Banerjee; Hagan Bayley; Stephen J Tucker
Peptide backbone mutagenesis of putative gating hinges in a potassium ion channel.
Chembiochem : a European journal of chemical biology 2008;9(11):1725-8.
2008: Stephen J Tucker; Thomas Baukrowitz
How highly charged anionic lipids bind and regulate ion channels.
The Journal of general physiology 2008;131(5):431-8.
2008: Lijun Shang; Stephen J Tucker
Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.
European biophysics journal : EBJ 2008;37(2):165-71.
2007: haider shozeb; Syma Khalid; Stephen J Tucker; Frances M Ashcroft; Mark S P Sansom
Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.
Biochemistry 2007;46(12):3643-52.
2006: Si Sun; Jo Han Gan; Jennifer J Paynter; Stephen J Tucker
Cloning and functional characterization of a superfamily of microbial inwardly rectifying potassium channels.
Physiological genomics 2006;26(1):1-7.
2003: Maria Casamassima; Maria Cristina D'Adamo; Mauro Pessia; Stephen J Tucker
Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.
The Journal of biological chemistry 2003;278(44):43533-40.
2003: Angelos-Aristeidis Konstas; Christoph Korbmacher; Stephen J Tucker
Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.
American journal of physiology. Cell physiology 2003;284(4):C910-7.
2002: Angelos-Aristeidis Konstas; Jan-Peter Koch; Stephen J Tucker; Christoph Korbmacher
Cystic fibrosis transmembrane conductance regulator-dependent up-regulation of Kir1.1 (ROMK) renal K+ channels by the epithelial sodium channel.
The Journal of biological chemistry 2002;277(28):25377-84.
2002: Angelos-Aristeidis Konstas; Michael Dabrowski; Christoph Korbmacher; Stephen J Tucker
Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel.
The Journal of biological chemistry 2002;277(24):21346-51.
2001: P A Jones; Stephen J Tucker; Frances M Ashcroft
Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.
FEBS letters 2001;508(1):85-9.
2001: Mauro Pessia; Paola Imbrici; Maria Cristina D'Adamo; L Salvatore; Stephen J Tucker
Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1.
The Journal of physiology 2001;532(Pt 2):359-67.
2000: Paola Imbrici; Stephen J Tucker; Maria Cristina D'Adamo; Mauro Pessia
Role of receptor protein tyrosine phosphatase alpha (RPTPalpha) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels.
Pflügers Archiv : European journal of physiology 2000;441(2-3):257-62.
2000: Fiona M Gribble; Gildas Loussouarn; Stephen J Tucker; C Zhao; Colin G Nichols; Frances M Ashcroft
A novel method for measurement of submembrane ATP concentration.
The Journal of biological chemistry 2000;275(39):30046-9.
2000: Kouichi Tanabe; Stephen J Tucker; FM Ashcroft; Peter Proks; Noriyuki Kioka; Teruo Amachi; Kunihiro Ueda
Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide.
Biochemical and biophysical research communications 2000;272(2):316-9.
2000: Stephen J Tucker; Paola Imbrici; L Salvatore; Maria Cristina D'Adamo; Mauro Pessia
pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia.
The Journal of biological chemistry 2000;275(22):16404-7.
1999: Stephen J Tucker; Frances M Ashcroft
Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.
The Journal of biological chemistry 1999;274(47):33393-7.
1999: Frank Reimann; T J Ryder; Stephen J Tucker; Frances M Ashcroft
The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.
The Journal of physiology 1999;520 Pt 3():661-9.
1999: Michinori Matsuo; Stephen J Tucker; FM Ashcroft; Teruo Amachi; Kunihiro Ueda
NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1.
FEBS letters 1999;458(3):292-4.
1999: Frank Reimann; Stephen J Tucker; Peter Proks; Frances M Ashcroft
Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.
The Journal of physiology 1999;518 ( Pt 2)():325-36.
1999: Kouichi Tanabe; Stephen J Tucker; Michinori Matsuo; Peter Proks; FM Ashcroft; Susumu Seino; Teruo Amachi; Kunihiro Ueda
Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.
The Journal of biological chemistry 1999;274(7):3931-3.
1999: Peter Proks; Fiona M Gribble; R Adhikari; Stephen J Tucker; Frances M Ashcroft
Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
The Journal of physiology 1999;514 ( Pt 1)():19-25.
1998: Fiona M Gribble; Stephen J Tucker; S Seino; Frances M Ashcroft
Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.
Diabetes 1998;47(9):1412-8.
1998: Stefan Trapp; Peter Proks; Stephen J Tucker; Frances M Ashcroft
Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.
The Journal of general physiology 1998;112(3):333-49.
1998: Stefan Trapp; Stephen J Tucker; Frances M Ashcroft
Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification.
The Journal of general physiology 1998;112(3):325-32.
1998: Y Takada; Kenneth M Yamada; Yoshitomo Taguchi; K Kino; Michinori Matsuo; Stephen J Tucker; Tohru Komano; Teruo Amachi; Kunihiro Ueda
Non-equivalent cooperation between the two nucleotide-binding folds of P-glycoprotein.
Biochimica et biophysica acta 1998;1373(1):131-6.
1998: Stephen J Tucker; Fiona M Gribble; Peter Proks; Stefan Trapp; T J Ryder; T Haug; Frank Reimann; Frances M Ashcroft
Molecular determinants of KATP channel inhibition by ATP.
The EMBO journal 1998;17(12):3290-6.
1998: Fiona M Gribble; Stephen J Tucker; T Haug; Frances M Ashcroft
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7185-90.
1998: Stephen J Tucker; Frances M Ashcroft
A touching case of channel regulation: the ATP-sensitive K+ channel.
Current opinion in neurobiology 1998;8(3):316-20.
1997: Fiona M Gribble; Stephen J Tucker; Frances M Ashcroft
The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation.
The Journal of physiology 1997;504 ( Pt 1)():35-45.
1997: S Trapp; Stephen J Tucker; Frances M Ashcroft
Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8872-7.
1997: Stephen J Tucker; Fiona M Gribble; C Zhao; Stefan Trapp; Frances M Ashcroft
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
Nature 1997;387(6629):179-83.
1997: Fiona M Gribble; Stephen J Tucker; Frances M Ashcroft
The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.
The EMBO journal 1997;16(6):1145-52.