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Edward Tuddenham

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Jenny McIntosh; John H McVey; Federico Mingozzi; Christopher L Morton; Maria Cancio; Olivier D Christophe; Andrew M Davidoff; Paolo Fagone; John T Gray; Katherine A High; Doyoung Lee; Peter J Lenting; Catherine Y C Ng; Arthur W Nienhuis; Nishil Patel; Samira Rabbanian; Deepak Raj; Cecilia Rosales; Edward G D Tuddenham; Simon Waddington; Junfang Zhou; Shang-Zhen Zhou; Amit C Nathwani
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant.
F Y Huq; A Kulkarni; Anne F Riddell; Edward G D Tuddenham; E C Agbim; Rezan A Kadir
Changes in the levels of factor VIII and von Willebrand factor in the puerperium.
Christopher Binny; Suzanne M K Buckley; Francis J Castellino; Andrew M Davidoff; marco della peruta; John T Gray; Hanna Kymalainen; Jenny McIntosh; John H McVey; Christopher L Morton; Yunyu Spence; Alice Tarantal; Adrian J Thrasher; Edward G D Tuddenham; Simon Waddington; Amit C Nathwani
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.

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2013: Jenny McIntosh; John H McVey; Federico Mingozzi; Christopher L Morton; Maria Cancio; Olivier D Christophe; Andrew M Davidoff; Paolo Fagone; John T Gray; Katherine A High; Doyoung Lee; Peter J Lenting; Catherine Y C Ng; Arthur W Nienhuis; Nishil Patel; Samira Rabbanian; Deepak Raj; Cecilia Rosales; Edward G D Tuddenham; Simon Waddington; Junfang Zhou; Shang-Zhen Zhou; Amit C Nathwani
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant.
Blood 2013;121(17):3335-44.
2012: F Y Huq; A Kulkarni; Anne F Riddell; Edward G D Tuddenham; E C Agbim; Rezan A Kadir
Changes in the levels of factor VIII and von Willebrand factor in the puerperium.
Haemophilia : the official journal of the World Federation of Hemophilia 2012;18(2):241-5.
2012: Christopher Binny; Suzanne M K Buckley; Francis J Castellino; Andrew M Davidoff; marco della peruta; John T Gray; Hanna Kymalainen; Jenny McIntosh; John H McVey; Christopher L Morton; Yunyu Spence; Alice Tarantal; Adrian J Thrasher; Edward G D Tuddenham; Simon Waddington; Amit C Nathwani
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.
Blood 2012;119(4):957-66.
2011: N Avrion Mitchison; Shomi Bhattacharya; Edward G D Tuddenham
Human congenital diseases with mixed modes of inheritance have a shortage of recessive disease. A demographic scenario?
Annals of human genetics 2011;75(6):688-93.
2011: Anne F Riddell; Edward G D Tuddenham; Rezan Abdul-Kadir; Debra Pollard; Keith Gomez
Monitoring low dose recombinant factor VIIa therapy in patients with severe factor XI deficiency undergoing surgery.
Thrombosis and haemostasis 2011;106(3):521-7.
2011: Natalie J Ward; Suzanne M K Buckley; Simon Waddington; Thierry Vandendriessche; Marinee K L Chuah; Amit C Nathwani; Jenny McIntosh; Edward G D Tuddenham; Christine Kinnon; Adrian J Thrasher; John H McVey
Codon optimization of human factor VIII cDNAs leads to high-level expression.
Blood 2011;117(3):798-807.
2010: Claudia Chi; D Pollard; Edward G D Tuddenham; Rezan A Kadir
Menorrhagia in adolescents with inherited bleeding disorders.
Journal of pediatric and adolescent gynecology 2010;23(4):215-22.
2009: Alex Gatt; Anne F Riddell; joost van veen; Steve Kitchen; Edward G D Tuddenham; Michael Makris
Optimizing warfarin reversal--an ex vivo study.
Journal of thrombosis and haemostasis : JTH 2009;7(7):1123-7.
2009: Baolai Hua; Liankai Fan; Yan Liang; Yongqiang Zhao; Edward G D Tuddenham
Alpha1-antitrypsin Pittsburgh in a family with bleeding tendency.
Haematologica 2009;94(6):881-4.
2008: V Calvaruso; S Maimone; Alex Gatt; Edward G D Tuddenham; Mark Thursz; M Pinzani; Andrew Kenneth Burroughs
Coagulation and fibrosis in chronic liver disease.
Gut 2008;57(12):1722-7.
2008: Edward G D Tuddenham
Killing 2 birds with 1 stone.
Blood 2008;112(7):2595.
2008: Daniel P Gale; Sarah K Harten; Cecil D L Reid; Edward G D Tuddenham; Patrick H Maxwell
Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.
Blood 2008;112(3):919-21.
2008: Edward G D Tuddenham; Jørgen Ingerslev; L Norengaard Sørensen; K Christiansen; G Mariani; Flora Peyvandi; Simon Waddington; S M K Buckley; S Kochanek; M K Chuah; T Vandendriessche; Erik Berntorp
Genetic aspects and research development in haemostasis.
Haemophilia : the official journal of the World Federation of Hemophilia 2008;14 Suppl 3():113-8.
2008: Bin Zhang; Marta Spreafico; Chunlei zheng; Angela Yang; Petra Platzer; Michael U Callaghan; Zekai Avci; Namik Ozbek; Johnny Mahlangu; Tabitha Haw; Randal J Kaufman; Kandice Marchant; Edward G D Tuddenham; Uri Seligsohn; Flora Peyvandi; David Ginsburg
Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.
Blood 2008;111(12):5592-600.
2007: Amit C Nathwani; John T Gray; Jenny McIntosh; Catherine Y C Ng; Junfang Zhou; Yunyu Spence; Melanie Cochrane; Elaine Gray; Edward G D Tuddenham; Andrew M Davidoff
Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates.
Blood 2007;109(4):1414-21.
2007: Morteza Karimipoor; Sirous Zeinali; Nafiseh Nafissi; Edward G D Tuddenham; Manijeh Lak; Reza Safaee
Identification of factor IX mutations in Iranian haemophilia B patients by SSCP and sequencing.
Thrombosis research 2007;120(1):135-9.
2006: Daxin Chen; M Weber; P G Shiels; R Dong; Zoe Webster; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; R I Lechler; Anthony Dorling
Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins.
Journal of thrombosis and haemostasis : JTH 2006;4(10):2191-8.
2006: H Douglas; GJ Davies; Katerina Michaelides; DA Gorog; H Timlin; N Ahmed; Edward G D Tuddenham
Detection of functional differences between different platelet membrane glycoprotein Ibalpha variable number tandem repeat and Kozak genotypes as shown by the PFA-100 system.
Heart (British Cardiac Society) 2006;92(5):676-8.
2006: Amit C Nathwani; John T Gray; Catherine Y C Ng; Junfang Zhou; Yunyu Spence; Simon Waddington; Edward G D Tuddenham; Geoffrey Kemball-Cook; Jenny McIntosh; Mariette Boon-Spijker; Koen Mertens; Andrew M Davidoff
Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver.
Blood 2006;107(7):2653-61.
2006: Bin Zhang; Beth McGee; Jennifer S Yamaoka; Hugo Guglielmone; Katharine A Downes; Salvador Minoldo; Gustavo Jarchum; Flora Peyvandi; Norma de Bosch; Arlette Ruiz-Saez; Bernard Chatelain; Marian Olpinski; Paula L Bockenstedt; Wolfgang Sperl; Randal J Kaufman; William C Nichols; Edward G D Tuddenham; David Ginsburg
Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2.
Blood 2006;107(5):1903-7.
2006: Katerina Michaelides; Edward G D Tuddenham; Cathy Turner; Ben Lavender; Stuart A Lavery
Live birth following the first mutation specific pre-implantation genetic diagnosis for haemophilia A.
Thrombosis and haemostasis 2006;95(2):373-9.
2006: Edward G D Tuddenham
Ways to bypass a blocked tenase complex.
Thrombosis and haemostasis 2006;95(1):1-2.
2005: Keith Gomez; John H McVey; Edward G D Tuddenham
Inhibition of coagulation by macromolecular complexes.
Haematologica 2005;90(11):1570-6.
2005: Hai Po Helena Liang; Marie-Christine Morel-Kopp; Jeannine M Clemetson; Kenneth J Clemetson; riitta marjut kekomaki; Hartmut Kroll; Katerina Michaelides; Edward G D Tuddenham; Karen Vanhoorelbeke; Christopher M Ward
A common ancestral glycoprotein (GP) 9 1828A>G (Asn45Ser) gene mutation occurring in European families from Australia and Northern Europe with Bernard-Soulier Syndrome (BSS).
Thrombosis and haemostasis 2005;94(3):599-605.
2005: Christiane Albrecht; John H McVey; James I Elliott; Alessandro Sardini; Ildiko Kasza; Andrew D Mumford; Rossi P Naoumova; Edward G D Tuddenham; Katalin Szabo; Christopher F Higgins
A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.
Blood 2005;106(2):542-9.
2005: John H McVey; Kalpana Lal; Yasufumi Imanaka; Geoffrey Kemball-Cook; Paula H B Bolton-Maggs; Edward G D Tuddenham
Characterisation of blood coagulation factor XI T475I.
Thrombosis and haemostasis 2005;93(6):1082-8.
2005: Edward G D Tuddenham
Gene therapy for hemophilia? Gene therapy for hemophilia is both desirable and achievable in the near future.
Journal of thrombosis and haemostasis : JTH 2005;3(6):1314.
2005: Edward G D Tuddenham
Factor VII and cardiovascular risk.
Thrombosis and haemostasis 2005;93(2):189.
2005: Dominic J Harrington; Sarah Underwood; Colin Morse; Martin Shearer; Edward G D Tuddenham; Andrew D Mumford
Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.
Thrombosis and haemostasis 2005;93(1):23-6.
2004: Daxin Chen; Michele Weber; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; Robert I Lechler; Anthony Dorling
Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(12):1958-63.
2004: Simon Waddington; Megha Nivsarkar; Ajay R Mistry; Suzanne Buckley; Geoffrey Kemball-Cook; Karen L Mosley; Kyriacos A Mitrophanous; Pippa Radcliffe; Maxine V Holder; Mairi Brittan; Anastasios Georgiadis; Faisal Al-Allaf; Brian W Bigger; Lisa G Gregory; H Terence Cook; Robin R Ali; Adrian J Thrasher; Edward G D Tuddenham; Michael Themis; Charles Coutelle
Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.
Blood 2004;104(9):2714-21.
2004: Daxin Chen; Konstantinos Giannopoulos; Paul G Shiels; Zoe Webster; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; Marilyn Moore; Robert Lechler; Anthony Dorling
Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium.
Blood 2004;104(5):1344-9.
2004: Amit C Nathwani; Andrew M Davidoff; Edward G D Tuddenham
Prospects for gene therapy of haemophilia.
Haemophilia : the official journal of the World Federation of Hemophilia 2004;10(4):309-18.
2004: Keith Gomez; Michael A Laffan; Geoffrey Kemball-Cook; John Pasi; Mark Layton; Jack D Singer; Edward G D Tuddenham; John H McVey
Two novel mutations in severe factor VII deficiency.
British journal of haematology 2004;126(1):105-10.
2004: Mårten Steen; Eva A Norstrøm; Ann-Louise Tholander; Paula H B Bolton-Maggs; Andrew D Mumford; John H McVey; Edward G D Tuddenham; Björn Dahlbäck
Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis.
Blood 2004;103(9):3381-7.
2004: Simone Rost; Andreas Fregin; Vytautas Ivaskevicius; Ernst Conzelmann; Konstanze Hörtnagel; Hans-Joachim Pelz; Knut Lappegard; Erhard Seifried; Inge Scharrer; Edward G D Tuddenham; Clemens R Müller; Tim M Strom; Johannes Oldenburg
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Nature 2004;427(6974):537-41.
2004: James I Elliott; Andrew D Mumford; Christiane Albrecht; Peter W Collins; John C Giddings; Christopher F Higgins; Edward G D Tuddenham; John H McVey
Characterisation of lymphocyte responses to Ca2+ in Scott syndrome.
Thrombosis and haemostasis 2004;91(2):412-5.
2004: Johannes Oldenburg; Jörg Schröder; Hans H Brackmann; Clemens Müller-Reible; Rainer Schwaab; Edward G D Tuddenham
Environmental and genetic factors influencing inhibitor development.
Seminars in hematology 2004;41(1 Suppl 1):82-8.
2003: Andrew D Mumford; John H McVey; Colin Morse; Keith Gomez; Mårten Steen; E A Norstrom; Edward G D Tuddenham; B Dahlback; Paula H B Bolton-Maggs
Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.
British journal of haematology 2003;123(3):496-501.
2003: E B Bachli; C M Pech; K M Johnson; D J D Johnson; Edward G D Tuddenham; John H McVey
Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.
Journal of thrombosis and haemostasis : JTH 2003;1(9):1935-44.
2003: C J Davidson; Edward G D Tuddenham; John H McVey
450 million years of hemostasis.
Journal of thrombosis and haemostasis : JTH 2003;1(7):1487-94.
2003: Bin Zhang; Michael A Cunningham; William C Nichols; John A Bernat; Uri Seligsohn; Steven W Pipe; John H McVey; Ursula Schulte-Overberg; Norma de Bosch; Arlette Ruiz-Saez; Gilbert C White; Edward G D Tuddenham; Randal J Kaufman; David Ginsburg
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.
Nature genetics 2003;34(2):220-5.
2003: Edward G D Tuddenham
In search of the eighth factor: a personal reminiscence.
Journal of thrombosis and haemostasis : JTH 2003;1(3):403-9.
2003: Colin J Davidson; Robert Hirt; Kalpana Lal; Philip Snell; greg elgar; Edward G D Tuddenham; John H McVey
Molecular evolution of the vertebrate blood coagulation network.
Thrombosis and haemostasis 2003;89(3):420-8.
2003: Dezsö David; I M A Santos; K Johnson; Edward G D Tuddenham; John H McVey
Analysis of the consequences of premature termination codons within factor VIII coding sequences.
Journal of thrombosis and haemostasis : JTH 2003;1(1):139-46.
2002: Evgueni L Saenko; Natalya M Ananyeva; Edward G D Tuddenham; Geoffrey Kemball-Cook
Factor VIII - novel insights into form and function.
British journal of haematology 2002;119(2):323-31.
2002: Edward G D Tuddenham
RNA as drug and antidote.
Nature 2002;419(6902):23-4.
2002: Nina Salooja; Geoffrey Kemball-Cook; Edward G D Tuddenham; Julian Dyson
Use of a non-depleting anti-CD4 antibody to modulate the immune response to coagulation factors VIII and IX.
British journal of haematology 2002;118(3):839-42.
2002: H Douglas; Katerina Michaelides; DA Gorog; Emanuele Durante Mangoni; N Ahmed; GJ Davies; Edward G D Tuddenham
Platelet membrane glycoprotein Ibalpha gene -5T/C Kozak sequence polymorphism as an independent risk factor for the occurrence of coronary thrombosis.
Heart (British Cardiac Society) 2002;87(1):70-4.
2001: D Chen; K Riesbeck; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; Robert I Lechler; Anthony Dorling
Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins.
Xenotransplantation 2001;8(4):258-65.
2001: Dezsö David; Evgueni L Saenko; I M Santos; D J Johnson; Edward G D Tuddenham; John H McVey; Geoffrey Kemball-Cook
Stable recombinant expression and characterization of the two haemophilic factor VIII variants C329S (CRM(-)) and G1948D (CRM(r)).
British journal of haematology 2001;113(3):604-15.
2001: John H McVey; E Boswell; Andrew D Mumford; Geoffrey Kemball-Cook; Edward G D Tuddenham
Factor VII deficiency and the FVII mutation database.
Human mutation 2001;17(1):3-17.
2000: David S Millar; Geoffrey Kemball-Cook; John H McVey; Edward G D Tuddenham; Andrew D Mumford; G B Attock; Joan Carles Reverter; N Lanir; Liakat A Parapia; J Reynaud; E Meili; A von Felton; Uri martinowitz; D R Prangnell; Michael Krawczak; David N Cooper
Molecular analysis of the genotype-phenotype relationship in factor VII deficiency.
Human genetics 2000;107(4):327-42.
2000: Masaru Shibata; Midori Shima; Shogo Morichika; John H McVey; Edward G D Tuddenham; Ichiro Tanaka; Hiroshi Suzuki; Keiji Nogami; Yoko Minamoto; Takaaki Hato; Evgueni L Saenko; Dorothea Scandella; Akira Yoshioka
An alloantibody recognizing the FVIII A1 domain in a patient with CRM reduced haemophilia A due to deletion of a large portion of the A1 domain DNA sequence.
Thrombosis and haemostasis 2000;84(3):442-8.
2000: Anthony Dorling; D Chen; K Riesbeck; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; Robert I Lechler
Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis.
Transplantation proceedings 2000;32(5):971.
1999: Geoffrey Kemball-Cook; D J Johnson; Edward G D Tuddenham; K Harlos
Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla).
Journal of structural biology 1999;127(3):213-23.
1999: Marguerite Neerman-Arbez; K M Johnson; Michael Morris; J H McVey; Flora Peyvandi; William C Nichols; David Ginsburg; Colette Rossier; Stylianos E Antonarakis; Edward G D Tuddenham
Molecular analysis of the ERGIC-53 gene in 35 families with combined factor V-factor VIII deficiency.
Blood 1999;93(7):2253-60.
1999: D J Johnson; P G Nugent; Edward G D Tuddenham; K Harlos; Geoffrey Kemball-Cook
Crystallization and preliminary X-ray analysis of active site-inhibited human coagulation factor VIIa (des-Gla).
Journal of structural biology 1999;125(1):90-3.
1999: D Chen; K Riesbeck; Geoffrey Kemball-Cook; John H McVey; Edward G D Tuddenham; Robert I Lechler; Anthony Dorling
Inhibition of tissue factor-dependent and -independent coagulation by cell surface expression of novel anticoagulant fusion proteins.
Transplantation 1999;67(3):467-74.
1999: Edward G D Tuddenham
Molecular biological aspects of inhibitor development.
Vox sanguinis 1999;77 Suppl 1():13-6.
1999: Emanuele Durante Mangoni; G J Davies; Edward G D Tuddenham; G Ruggiero
Factor V Leiden in patients with acute coronary syndromes.
Annali italiani di medicina interna : organo ufficiale della Società italiana di medicina interna 1999;14(1):15-9.
1998: E P Mansvelt; Michael A Laffan; John H McVey; Edward G D Tuddenham
Analysis of the F8 gene in individuals with high plasma factor VIII: C levels and associated venous thrombosis.
Thrombosis and haemostasis 1998;80(4):561-5.
1998: T Taniguchi; Ajay K Kakkar; Edward G D Tuddenham; Robin C N Williamson; Nick Lemoine
Enhanced expression of urokinase receptor induced through the tissue factor-factor VIIa pathway in human pancreatic cancer.
Cancer research 1998;58(19):4461-7.
1998: Michael A Laffan; Edward G D Tuddenham
Science, medicine, and the future: assessing thrombotic risk.
BMJ (Clinical research ed.) 1998;317(7157):520-3.
1998: Emanuele Durante Mangoni; G J Davies; N Ahmed; G Ruggiero; Edward G D Tuddenham
Coronary thrombosis and the platelet glycoprotein IIIA gene PLA2 polymorphism.
Thrombosis and haemostasis 1998;80(2):218-9.
1998: John H McVey; E J Boswell; O Takamiya; G Tamagnini; V Valente; T Fidalgo; Mark Layton; Edward G D Tuddenham
Exclusion of the first EGF domain of factor VII by a splice site mutation causes lethal factor VII deficiency.
Blood 1998;92(3):920-6.
1998: Edward G D Tuddenham; John H McVey
The genetic basis of inhibitor development in haemophilia A.
Haemophilia : the official journal of the World Federation of Hemophilia 1998;4(4):543-5.
1998: Geoffrey Kemball-Cook; D J Johnson; O Takamiya; D W Banner; John H McVey; Edward G D Tuddenham
Coagulation factor VII Gln100 --> Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor binding and procoagulant function.
The Journal of biological chemistry 1998;273(14):8516-21.
1998: Flora Peyvandi; Edward G D Tuddenham; A M Akhtari; Manijeh Lak; Pier M Mannucci
Bleeding symptoms in 27 Iranian patients with the combined deficiency of factor V and factor VIII.
British journal of haematology 1998;100(4):773-6.
1998: Geoffrey Kemball-Cook; Edward G D Tuddenham; AI Wacey
The factor VIII Structure and Mutation Resource Site: HAMSTeRS version 4.
Nucleic acids research 1998;26(1):216-9.
1997: Rainer Schwaab; Johannes Oldenburg; M R Lalloz; Ulrike Schwaab; S Pemberton; Peter Hanfland; Hans H Brackmann; Edward G D Tuddenham; Katerina Michaelides
Factor VIII gene mutations found by a comparative study of SSCP, DGGE and CMC and their analysis on a molecular model of factor VIII protein.
Human genetics 1997;101(3):323-32.
1997: Shogo Morichika; Midori Shima; Seiki Kamisue; Ichiro Tanaka; Y Imanaka; Hiroshi Suzuki; H Shibata; S Pemberton; K Gale; John H McVey; Edward G D Tuddenham; Akira Yoshioka
Factor VIII gene analysis in Japanese CRM-positive and CRM-reduced haemophilia A patients by single-strand conformation polymorphism.
British journal of haematology 1997;98(4):901-6.
1997: Michael A Laffan; Edward G D Tuddenham
Thrombophilia: an expanding group of genetic defects that predispose to thrombosis.
Molecular medicine today 1997;3(7):303-9.
1997: Marguerite Neerman-Arbez; Stylianos E Antonarakis; Jean-Louis Blouin; Sirous Zeinali; M Akhtari; Y Afshar; Edward G D Tuddenham
The locus for combined factor V-factor VIII deficiency (F5F8D) maps to 18q21, between D18S849 and D18S1103.
American journal of human genetics 1997;61(1):143-50.
1997: David N Cooper; David S Millar; AI Wacey; S Pemberton; Edward G D Tuddenham
Inherited factor X deficiency: molecular genetics and pathophysiology.
Thrombosis and haemostasis 1997;78(1):161-72.
1997: David N Cooper; David S Millar; AI Wacey; D W Banner; Edward G D Tuddenham
Inherited factor VII deficiency: molecular genetics and pathophysiology.
Thrombosis and haemostasis 1997;78(1):151-60.
1997: Michael A Laffan; Edward G D Tuddenham
Inherited thrombophilias.
QJM : monthly journal of the Association of Physicians 1997;90(6):375-8.
1997: Hiroshi Suzuki; Midori Shima; M Arai; K Kagawa; K Fukutake; Seiki Kamisue; H Nakai; Shogo Morichika; Ichiro Tanaka; M Inoue; K Gale; Edward G D Tuddenham; Akira Yoshioka
Factor VIII Ise (R2159C) in a patient with mild hemophilia A, an abnormal factor VIII with retention of function but modification of C2 epitopes.
Thrombosis and haemostasis 1997;77(5):862-7.
1997: James O'Donnell; Edward G D Tuddenham; Richard A Manning; Geoffrey Kemball-Cook; D Johnson; Michael A Laffan
High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction.
Thrombosis and haemostasis 1997;77(5):825-8.
1997: S Pemberton; Peter F Lindley; Viatcheslav N Zaitsev; G Card; Edward G D Tuddenham; Geoffrey Kemball-Cook
A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin.
Blood 1997;89(7):2413-21.
1997: Johannes Oldenburg; J K Picard; Rainer Schwaab; Hans H Brackmann; Edward G D Tuddenham; E Simpson
HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII.
Thrombosis and haemostasis 1997;77(2):238-42.
1997: Geoffrey Kemball-Cook; Edward G D Tuddenham
The Factor VIII Mutation Database on the World Wide Web: the haemophilia A mutation, search, test and resource site. HAMSTeRS update (version 3.0).
Nucleic acids research 1997;25(1):128-32.
1996: C J Formstone; P J Hallam; Edward G D Tuddenham; J Voke; M Layton; K Nicolaides; I M Hann; David N Cooper
Severe perinatal thrombosis in double and triple heterozygous offspring of a family segregating two independent protein S mutations and a protein C mutation.
Blood 1996;87(9):3731-7.
1996: Edward G D Tuddenham
The tissue factor-factor VII complex: recent advances towards elucidating the structure and function of the initiator of haemostasis.
Haemostasis 1996;26 Suppl 1():20-4.
1996: AI Wacey; Geoffrey Kemball-Cook; Haig Kazazian ; Stylianos Antonarakis; R Schwaab; Peter F Lindley; Edward G D Tuddenham
The haemophilia A mutation search test and resource site, home page of the factor VIII mutation database: HAMSTeRS.
Nucleic acids research 1996;24(1):100-2.
1995: Rainer Schwaab; Hans H Brackmann; C Meyer; J Seehafer; M Kirchgesser; A Haack; K Olek; Edward G D Tuddenham; Johannes Oldenburg
Haemophilia A: mutation type determines risk of inhibitor formation.
Thrombosis and haemostasis 1995;74(6):1402-6.
1995: G Miller; R A Steinbrecher; Paul J Murdock; Edward G D Tuddenham; Christine A Lee; K John Pasi; Geoffrey Goldspink
Expression of factor VII by muscle cells in vitro and in vivo following direct gene transfer: modelling gene therapy for haemophilia.
Gene therapy 1995;2(10):736-42.
1995: A W Ashton; Geoffrey Kemball-Cook; D J Johnson; D M Martin; D P O'Brien; Edward G D Tuddenham; Stephen J Perkins
Factor VIIa and the extracellular domains of human tissue factor form a compact complex: a study by X-ray and neutron solution scattering.
FEBS letters 1995;374(1):141-6.
1995: Rainer Schwaab; Johannes Oldenburg; U Schwaab; D J Johnson; W Schmidt; K Olek; H H Brackman; Edward G D Tuddenham
Characterization of mutations within the factor VIII gene of 73 unrelated mild and moderate haemophiliacs.
British journal of haematology 1995;91(2):458-64.
1995: C J Formstone; AI Wacey; L P Berg; S Rahman; D Bevan; M Rowley; J Voke; F Bernardi; C Legnani; P Simioni; A Girolami; Edward G D Tuddenham; Vijay V Kakkar; David N Cooper
Detection and characterization of seven novel protein S (PROS) gene lesions: evaluation of reverse transcript-polymerase chain reaction as a mutation screening strategy.
Blood 1995;86(7):2632-41.
1995: Y Imanaka; K Lal; T Nishimura; P H Bolton-Maggs; Edward G D Tuddenham; John H McVey
Identification of two novel mutations in non-Jewish factor XI deficiency.
British journal of haematology 1995;90(4):916-20.
1995: Edward G D Tuddenham; S Pemberton; D N Cooper
Inherited factor VII deficiency: genetics and molecular pathology.
Thrombosis and haemostasis 1995;74(1):313-21.
1995: O Takamiya; S Abe; A Yoshioka; K Nakajima; J H McVey; Edward G D Tuddenham
Factor VIIShinjo: a dysfunctional factor VII variant homozygous for the substitution Gln for Arg at position 79.
Haemostasis 1995;25(3):89-97.
1995: R E Pugh; J H McVey; Edward G D Tuddenham; J F Hancock
Six point mutations that cause factor XI deficiency.
Blood 1995;85(6):1509-16.
1994: D P O'Brien; Geoffrey Kemball-Cook; A M Hutchinson; D M Martin; D J Johnson; P G Byfield; O Takamiya; Edward G D Tuddenham; John H McVey
Surface plasmon resonance studies of the interaction between factor VII and tissue factor. Demonstration of defective tissue factor binding in a variant FVII molecule (FVII-R79Q).
Biochemistry 1994;33(47):14162-9.
1994: Edward G D Tuddenham; Rainer Schwaab; J Seehafer; D S Millar; Jane Gitschier; M Higuchi; S Bidichandani; J M Connor; L W Hoyer; A Yoshioka
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition.
Nucleic acids research 1994;22(22):4851-68.
1994: David N Cooper; Edward G D Tuddenham
Molecular genetics of familial venous thrombosis.
British medical bulletin 1994;50(4):833-50.
1994: Edward G D Tuddenham; Rainer Schwaab; J Seehafer; D S Millar; Jane Gitschier; M Higuchi; S Bidichandani; J M Connor; L W Hoyer; A Yoshioka
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition.
Nucleic acids research 1994;22(17):3511-33.
1994: A C Nathwani; K M Gale; K D Pemberton; D C Crossman; Edward G D Tuddenham; John H McVey
Efficient gene transfer into human umbilical vein endothelial cells allows functional analysis of the human tissue factor gene promoter.
British journal of haematology 1994;88(1):122-8.
1994: L Kochhan; M R Lalloz; Johannes Oldenburg; John H McVey; K Olek; Hans H Brackmann; Edward G D Tuddenham; Rainer Schwaab
Haemophilia A diagnosis by automated fluorescent DNA detection of ten factor VIII intron 13 dinucleotide repeat alleles.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1994;5(4):497-501.
1994: Edward G D Tuddenham
Thrombophilia: the new factor is old factor V.
Lancet 1994;343(8912):1515-6.
1994: D J Johnson; S Pemberton; M Acquila; Pier Giorgio Mori; Edward G D Tuddenham; D P O'Brien
Factor VIII S373L: mutation at P1' site confers thrombin cleavage resistance, causing mild haemophilia A.
Thrombosis and haemostasis 1994;71(4):428-33.
1994: M R Lalloz; Rainer Schwaab; John H McVey; K Michaelides; Edward G D Tuddenham
Haemophilia A diagnosis by simultaneous analysis of two variable dinucleotide tandem repeats within the factor VIII gene.
British journal of haematology 1994;86(4):804-9.
1994: Geoffrey Kemball-Cook; I Garner; Y Imanaka; T Nishimura; D P O'Brien; Edward G D Tuddenham; John H McVey
High-level production of human blood coagulation factors VII and XI using a new mammalian expression vector.
Gene 1994;139(2):275-9.
1993: D M Martin; D P O'Brien; Edward G D Tuddenham; P G Byfield
Synthesis and characterization of wild-type and variant gamma-carboxyglutamic acid-containing domains of factor VII.
Biochemistry 1993;32(50):13949-55.
1993: O Takamiya; Geoffrey Kemball-Cook; D M Martin; David N Cooper; A von Felten; E Meili; I Hann; D R Prangnell; H Lumley; Edward G D Tuddenham
Detection of missense mutations by single-strand conformational polymorphism (SSCP) analysis in five dysfunctional variants of coagulation factor VII.
Human molecular genetics 1993;2(9):1355-9.
1993: AI Wacey; S Pemberton; David N Cooper; Vijay V Kakkar; Edward G D Tuddenham
A molecular model of the serine protease domain of activated protein C: application to the study of missense mutations causing protein C deficiency.
British journal of haematology 1993;84(2):290-300.
1993: D P O'Brien; J S Anderson; D M Martin; P G Byfield; Edward G D Tuddenham
Structural requirements for the interaction between tissue factor and factor VII: characterization of chymotrypsin-derived tissue factor polypeptides.
The Biochemical journal 1993;292 ( Pt 1)():7-12.
1993: S D Wright; K Michaelides; D J Johnson; N C West; Edward G D Tuddenham
Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome.
Blood 1993;81(9):2339-47.
1993: John H McVey; K Michaelides; L P Hansen; M Ferguson-Smith; S Tilghman; R Krumlauf; Edward G D Tuddenham
A G-->A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP).
Human molecular genetics 1993;2(4):379-84.
1992: D P O'Brien; D Johnson; P Byfield; Edward G D Tuddenham
Inactivation of factor VIII by factor IXa.
Biochemistry 1992;31(10):2805-12.
1991: Edward G D Tuddenham; David N Cooper; Jane Gitschier; M Higuchi; L W Hoyer; A Yoshioka; I R Peake; Rainer Schwaab; K Olek; Haig Kazazian
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene.
Nucleic acids research 1991;19(18):4821-33.
1991: M R Lalloz; John H McVey; J K Pattinson; Edward G D Tuddenham
Haemophilia A diagnosis by analysis of a hypervariable dinucleotide repeat within the factor VIII gene.
Lancet 1991;338(8761):207-11.
1991: D P O'Brien; K M Gale; J S Anderson; John H McVey; G J Miller; T W Meade; Edward G D Tuddenham
Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male.
Blood 1991;78(1):132-40.
1990: Y Ohkubo; D P O'Brien; T Kanehiro; H Fukui; Edward G D Tuddenham
Characterization of a panel of monoclonal antibodies to human coagulation factor XI and detection of factor XI in Hep G2 cell conditioned medium.
Thrombosis and haemostasis 1990;63(3):417-23.
1990: D C Crossman; D P Carr; Edward G D Tuddenham; Jeremy Pearson; John H McVey
The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester.
The Journal of biological chemistry 1990;265(17):9782-7.
1990: J K Pattinson; John H McVey; M Boon; A Ajani; Edward G D Tuddenham
CRM+ haemophilia A due to a missense mutation (372----Cys) at the internal heavy chain thrombin cleavage site.
British journal of haematology 1990;75(1):73-7.
1990: D P O'Brien; J K Pattinson; Edward G D Tuddenham
Purification and characterization of factor VIII 372-Cys: a hypofunctional cofactor from a patient with moderately severe hemophilia A.
Blood 1990;75(8):1664-72.
1989: D P O'Brien; Edward G D Tuddenham
Purification and characterization of factor VIII 1,689-Cys: a nonfunctional cofactor occurring in a patient with severe hemophilia A.
Blood 1989;73(8):2117-22.
1989: Edward G D Tuddenham; T Takase; A E Thomas; abdalla awidi; F F Madanat; M M Abu Hajir; P B Kernoff; A V Hoffbrand
Homozygous protein C deficiency with delayed onset of symptoms at 7 to 10 months.
Thrombosis research 1989;53(5):475-84.
1989: N Thomas; U O'Callaghan; G D Lowe; V Olszynski; P B Kernoff; C F Abildgaard; Edward G D Tuddenham
Response to desmopressin in type IID von Willebrand's disease.
Clinical and laboratory haematology 1989;11(3):189-97.
1988: T Takase; Edward G D Tuddenham; S Chand; Alison H Goodall
Monoclonal antibodies to human factor VII: production of immunodepleted plasma for VII:C assays.
Journal of clinical pathology 1988;41(3):342-5.
1988: T Takase; Edward G D Tuddenham; S Chand; Alison H Goodall
Monoclonal antibodies to human factor VII: a one step immunoradiometric assay for VII:Ag.
Journal of clinical pathology 1988;41(3):337-41.
1987: T Takase; F Rotblat; Alison H Goodall; P B Kernoff; S Middleton; S Chand; K W Denson; D E Austen; Edward G D Tuddenham
Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies.
British journal of haematology 1987;66(4):497-502.
1987: A McCraw; S Chand; Edward G D Tuddenham; U O'Callaghan; Alison H Goodall
A monoclonal antibody based immunoradiometric assay for von Willebrand factor: survey of a large patient group.
Thrombosis research 1987;45(1):101-8.
1986: S Chand; A McCraw; R Hutton; Edward G D Tuddenham; Alison H Goodall
A two-site, monoclonal antibody-based immunoassay for von Willebrand factor--demonstration that vWF function resides in a conformational epitope.
Thrombosis and haemostasis 1986;55(3):318-24.
1985: F Rotblat; D P O'Brien; F J O'Brien; Alison H Goodall; Edward G D Tuddenham
Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.
Biochemistry 1985;24(16):4294-300.
1985: Alison H Goodall; J Jarvis; S Chand; E Rawlings; D P O'Brien; A McGraw; R Hutton; Edward G D Tuddenham
An immunoradiometric assay for human factor VIII/von Willebrand factor (VIII:vWF) using a monoclonal antibody that defines a functional epitope.
British journal of haematology 1985;59(4):565-77.
1983: F Rotblat; Alison H Goodall; D P O'Brien; E Rawlings; S Middleton; Edward G D Tuddenham
Monoclonal antibodies to human procoagulant factor VIII.
The Journal of laboratory and clinical medicine 1983;101(5):736-46.
1982: Edward G D Tuddenham; R S Lane; F Rotblat; A J Johnson; T J Snape; S Middleton; P B Kernoff
Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease.
British journal of haematology 1982;52(2):259-67.
1982: Alison H Goodall; George W Kemble; D P O'Brien; E Rawlings; F Rotblat; G C Russell; G Janossy; Edward G D Tuddenham
Preparation of factor IX deficient human plasma by immunoaffinity chromatography using a monoclonal antibody.
Blood 1982;59(3):664-70.
1982: F Rotblat; C Hawkey; D P O'Brien; Edward G D Tuddenham
Immunologic studies of factor VIII coagulant activity (VIII:C). 2. Factor VIII in selected vertebrates.
Thrombosis research 1982;25(5):423-31.