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Robert Tukey
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19
Strassburg, Christian
18
Manns, Michael
15
Quattrochi, Linda
12
Nguyen, Nghia
11
Pendurthi, Usha
8
Bonzo, Jessica
8
Chen, Shujuan
7
McManus, Michael
6
Birkett, Donald
6
Miners, John
6
Griffin, Keith
6
Yueh, Mei-Fei
5
Guengerich, Peter
5
Barut, Ayse
4
Beaton, Deirdre
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All Publications
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2008: Chouinard Sarah; Yueh Mei-Fei; Tukey Robert H; Giton Frank; Fiet Jean; Pelletier Georges; Barbier Olivier; Bélanger Alain
Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling.
The Journal of steroid biochemistry and molecular biology 2008;109(3-5):247-53.
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2008: Nguyen Nghia; Bonzo Jessica A; Chen Shujuan; Chouinard Sarah; Kelner Michael J; Hardiman Gary; Bélanger Alain; Tukey Robert H
Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease.
The Journal of biological chemistry 2008;283(12):7901-11.
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2007: Yueh Mei-Fei; Tukey Robert H
Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice.
The Journal of biological chemistry 2007;282(12):8749-58.
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2007: Senekeo-Effenberger Kathy; Chen Shujuan; Brace-Sinnokrak Erin; Bonzo Jessica A; Yueh Mei-Fei; Argikar Upendra; Kaeding Jenny; Trottier Jocelyn; Remmel Rory P; Ritter Joseph K; Barbier Olivier; Tukey Robert H
Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(3):419-27.
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2007: Bonzo Jessica A; Bélanger Alain; Tukey Robert H
The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice.
Hepatology (Baltimore, Md.) 2007;45(2):349-60.
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2007: Operaña Theresa N; Tukey Robert H
Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.
The Journal of biological chemistry 2007;282(7):4821-9.
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2007: Operaña Theresa N; Nguyen Nghia; Chen Shujuan; Beaton Deirdre; Tukey Robert H
Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(1):98-107.
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2006: Verreault Mélanie; Senekeo-Effenberger Kathy; Trottier Jocelyn; Bonzo Jessica A; Bélanger Julie; Kaeding Jenny; Staels Bart; Caron Patrick; Tukey Robert H; Barbier Olivier
The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.
Hepatology (Baltimore, Md.) 2006;44(2):368-78.
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2005: Chen Shujuan; Beaton Deirdre; Nguyen Nghia; Senekeo-Effenberger Kathy; Brace-Sinnokrak Erin; Argikar Upendra; Remmel Rory P; Trottier Jocelyn; Barbier Olivier; Ritter Joseph K; Tukey Robert H
Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.
The Journal of biological chemistry 2005;280(45):37547-57.
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2005: Machemer Daniel E W; Tukey Robert H
The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression.
Toxicological sciences : an official journal of the Society of Toxicology 2005;87(1):27-37.
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2005: Bonzo Jessica A; Chen Shujuan; Galijatovic Alema; Tukey Robert H
Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest.
Molecular pharmacology 2005;67(4):1247-56.
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2005: Chen Shujuan; Operaña Theresa; Bonzo Jessica; Nguyen Nghia; Tukey Robert H
ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation.
The Journal of biological chemistry 2005;280(6):4350-9.
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2005: Yueh Mei-Fei; Bonzo Jessica A; Tukey Robert H
The role of Ah receptor in induction of human UDP-glucuronosyltransferase 1A1.
Methods in enzymology 2005;400():75-91.
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2004: Galijatovic Alema; Beaton Deirdre; Nguyen Nghia; Chen Shujuan; Bonzo Jessica; Johnson Randall; Maeda Shin; Karin Michael; Guengerich F Peter; Tukey Robert H
The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice.
The Journal of biological chemistry 2004;279(23):23969-76.
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2003: Chen Shujuan; Nguyen Nghia; Tamura Kumiko; Karin Michael; Tukey Robert H
The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis.
The Journal of biological chemistry 2003;278(21):19526-33.
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2003: Xie Wen; Yeuh Mei-Fei; Radominska-Pandya Anna; Saini Simrat P S; Negishi Yoichi; Bottroff Bobbie Sue; Cabrera Geraldine Y; Tukey Robert H; Evans Ronald M
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4150-5.
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2003: Yueh Mei-Fei; Huang Yue-Hua; Hiller Anita; Chen Shujuan; Nguyen Nghia; Tukey Robert H
Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1.
The Journal of biological chemistry 2003;278(17):15001-6.
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2002: Tukey Robert H; Strassburg Christian P; Mackenzie Peter I
Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity.
Molecular pharmacology 2002;62(3):446-50.
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2002: Vogel A; Ockenga J; Ehmer U; Barut A; Kramer F-J; Tukey R H; Manns M P; Strassburg C P
Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer.
Zeitschrift für Gastroenterologie 2002;40(7):497-502.
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2002: Huang Yue-Hua; Galijatovic Alema; Nguyen Nghia; Geske Donald; Beaton Deirdre; Green Judith; Green Mark; Peters Wilbert H; Tukey Robert H
Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3.
Pharmacogenetics 2002;12(4):287-97.
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2002: Strassburg C P; Vogel A; Kneip S; Tukey R H; Manns M P
Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer.
Gut 2002;50(6):851-6.
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2002: Strassburg Ahlke; Strassburg Christian P; Manns Michael P; Tukey Robert H
Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue.
Molecular pharmacology 2002;61(2):320-5.
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2002: Strassburg C P; Strassburg A; Kneip S; Barut A; Tukey R H; Rodeck B; Manns M P
Developmental aspects of human hepatic drug glucuronidation in young children and adults.
Gut 2002;50(2):259-65.
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2001: Vogel A; Kneip S; Barut A; Ehmer U; Tukey R H; Manns M P; Strassburg C P
Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene.
Gastroenterology 2001;121(5):1136-44.
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2001: Strassburg C P; Barut A; Obermayer-Straub P; Li Q; Nguyen N; Tukey R H; Manns M P
Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7.
Journal of hepatology 2001;34(6):865-72.
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2001: Yueh M F; Nguyen N; Famourzadeh M; Strassburg C P; Oda Y; Guengerich F P; Tukey R H
The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines.
Carcinogenesis 2001;22(6):943-50.
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2001: Tukey R H; Strassburg C P
Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract.
Molecular pharmacology 2001;59(3):405-14.
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2000: Strassburg C P; Kneip S; Topp J; Obermayer-Straub P; Barut A; Tukey R H; Manns M P
Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.
The Journal of biological chemistry 2000;275(46):36164-71.
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2000: Li Q; Lamb G; Tukey R H
Characterization of the UDP-glucuronosyltransferase 1A locus in lagomorphs: evidence for duplication of the UGT1A6 gene.
Molecular pharmacology 2000;58(1):89-97.
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2000: Tukey R H; Strassburg C P
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Annual review of pharmacology and toxicology 2000;40():581-616.
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1999: Nowell S A; Massengill J S; Williams S; Radominska-Pandya A; Tephly T R; Cheng Z; Strassburg C P; Tukey R H; MacLeod S L; Lang N P; Kadlubar F F
Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved.
Carcinogenesis 1999;20(6):1107-14.
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1999: Hiller A; Nguyen N; Strassburg C P; Li Q; Jainta H; Pechstein B; Ruus P; Engel J; Tukey R H; Kronbach T
Retigabine N-glucuronidation and its potential role in enterohepatic circulation.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(5):605-12.
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1999: Strassburg C P; Strassburg A; Nguyen N; Li Q; Manns M P; Tukey R H
Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.
The Biochemical journal 1999;338 ( Pt 2)():489-98.
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1999: Strassburg C P; Nguyen N; Manns M P; Tukey R H
UDP-glucuronosyltransferase activity in human liver and colon.
Gastroenterology 1999;116(1):149-60.
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1998: Strassburg C P; Nguyen N; Manns M P; Tukey R H
Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium.
Molecular pharmacology 1998;54(4):647-54.
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1998: Strassburg C P; Manns M P; Tukey R H
Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8.
The Journal of biological chemistry 1998;273(15):8719-26.
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1997: Bruck M; Li Q; Lamb J G; Tukey R H
Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4.
Archives of biochemistry and biophysics 1997;348(2):357-64.
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1997: Strassburg C P; Oldhafer K; Manns M P; Tukey R H
Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.
Molecular pharmacology 1997;52(2):212-20.
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1997: Bruck M; Li Q; Lamb J G; Tukey R H
Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4.
Archives of biochemistry and biophysics 1997;344(2):357-64.
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1997: Strassburg C P; Manns M P; Tukey R H
Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer.
Cancer research 1997;57(14):2979-85.
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1997: Nguyen N; Tukey R H
Baculovirus-directed expression of rabbit UDP-glucuronosyltransferases in Spodoptera frugiperda cells.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(6):745-9.
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1997: Clemente M G; Obermayer-Straub P; Meloni A; Strassburg C P; Arangino V; Tukey R H; De Virgiliis S; Manns M P
Cytochrome P450 1A2 is a hepatic autoantigen in autoimmune polyglandular syndrome type 1.
The Journal of clinical endocrinology and metabolism 1997;82(5):1353-61.
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1997: Li Q; Lou X; Peyronneau M A; Straub P O; Tukey R H
Expression and functional domains of rabbit liver UDP-glucuronosyltransferase 2B16 and 2B13.
The Journal of biological chemistry 1997;272(6):3272-9.
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1996: Strassburg C P; Obermayer-Straub P; Alex B; Durazzo M; Rizzetto M; Tukey R H; Manns M P
Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis.
Gastroenterology 1996;111(6):1576-86.
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1996: Chen Y H; Tukey R H
Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor.
The Journal of biological chemistry 1996;271(42):26261-6.
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1996: Barwick J L; Quattrochi L C; Mills A S; Potenza C; Tukey R H; Guzelian P S
Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes.
Molecular pharmacology 1996;50(1):10-6.
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1996: Miners J O; Coulter S; Tukey R H; Veronese M E; Birkett D J
Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen.
Biochemical pharmacology 1996;51(8):1003-8.
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1996: Tassaneeyakul W; Birkett D J; Edwards J W; Veronese M E; Tassaneeyakul W; Tukey R H; Miners J O
Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene.
The Journal of pharmacology and experimental therapeutics 1996;276(1):101-8.
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1995: Philipp T; Straub P; Durazzo M; Tukey R H; Manns M P
Molecular analysis of autoantigens in hepatitis D.
Journal of hepatology 1995;22(1 Suppl):132-5.
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1994: Shimada T; Gillam E M; Sandhu P; Guo Z; Tukey R H; Guengerich F P
Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays.
Carcinogenesis 1994;15(11):2523-9.
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1994: Tassaneeyakul W; Birkett D J; Veronese M E; McManus M E; Tukey R H; Miners J O
Direct characterization of the selectivity of furafylline as an inhibitor of human cytochromes P450 1A1 and 1A2.
Pharmacogenetics 1994;4(5):281-4.
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1994: Lamb J G; Straub P; Tukey R H
Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Biochemistry 1994;33(34):10513-20.
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1994: Guo Z; Gillam E M; Ohmori S; Tukey R H; Guengerich F P
Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties.
Archives of biochemistry and biophysics 1994;312(2):436-46.
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1994: Philipp T; Durazzo M; Trautwein C; Alex B; Straub P; Lamb J G; Johnson E F; Tukey R H; Manns M P
Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D.
Lancet 1994;344(8922):578-81.
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1994: Tassaneeyakul W; Birkett D J; McManus M E; Tassaneeyakul W; Veronese M E; Andersson T; Tukey R H; Miners J O
Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms.
Biochemical pharmacology 1994;47(10):1767-76.
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1994: Quattrochi L C; Vu T; Tukey R H
The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction.
The Journal of biological chemistry 1994;269(9):6949-54.
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1994: Sandhu P; Guo Z; Baba T; Martin M V; Tukey R H; Guengerich F P
Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.
Archives of biochemistry and biophysics 1994;309(1):168-77.
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1993: Pendurthi U R; Okino S T; Tukey R H
Accumulation of the nuclear dioxin (Ah) receptor and transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes.
Archives of biochemistry and biophysics 1993;306(1):65-9.
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1993: Tukey R H; Pendurthi U R; Nguyen N T; Green M D; Tephly T R
Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13.
The Journal of biological chemistry 1993;268(20):15260-6.
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1993: Tassaneeyakul W; Birkett D J; Veronese M E; McManus M E; Tukey R H; Quattrochi L C; Gelboin H V; Miners J O
Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.
The Journal of pharmacology and experimental therapeutics 1993;265(1):401-7.
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1993: Okino S T; Pendurthi U R; Tukey R H
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces the nuclear translocation of two XRE binding proteins in mice.
Pharmacogenetics 1993;3(2):101-9.
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1993: Quattrochi L C; Tukey R H
Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene.
Molecular pharmacology 1993;43(4):504-8.
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1993: Postlind H; Vu T P; Tukey R H; Quattrochi L C
Response of human CYP1-luciferase plasmids to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons.
Toxicology and applied pharmacology 1993;118(2):255-62.
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1992: Tassaneeyakul W; Mohamed Z; Birkett D J; McManus M E; Veronese M E; Tukey R H; Quattrochi L C; Gonzalez F J; Miners J O
Caffeine as a probe for human cytochromes P450: validation using cDNA-expression, immunoinhibition and microsomal kinetic and inhibitor techniques.
Pharmacogenetics 1992;2(4):173-83.
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1992: Strom D K; Postlind H; Tukey R H
Characterization of the rabbit CYP1A1 and CYP1A2 genes: developmental and dioxin-inducible expression of rabbit liver P4501A1 and P4501A2.
Archives of biochemistry and biophysics 1992;294(2):707-16.
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1992: Okino S T; Pendurthi U R; Tukey R H
Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
The Journal of biological chemistry 1992;267(10):6991-8.
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1992: Pendurthi U R; Tukey R H; Rao L V
Characterization of a rabbit factor IX cDNA.
Thrombosis research 1992;65(2):177-86.
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1991: McKinnon R A; Hall P D; Quattrochi L C; Tukey R H; McManus M E
Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization.
Hepatology (Baltimore, Md.) 1991;14(5):848-56.
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1990: Pendurthi U R; Lamb J G; Nguyen N; Johnson E F; Tukey R H
Characterization of the CYP2C5 gene in 21L III/J rabbits. Allelic variation affects the expression of P450IIC5.
The Journal of biological chemistry 1990;265(24):14662-8.
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1990: Manns M P; Griffin K J; Quattrochi L C; Sacher M; Thaler H; Tukey R H; Johnson E F
Identification of cytochrome P450IA2 as a human autoantigen.
Archives of biochemistry and biophysics 1990;280(1):229-32.
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1990: McManus M E; Burgess W M; Veronese M E; Huggett A; Quattrochi L C; Tukey R H
Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.
Cancer research 1990;50(11):3367-76.
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1990: McManus M E; Burgess W M; Veronese M E; Felton J S; Knize M G; Snyderwine E G; Quattrochi L C; Tukey R H
Metabolism of food derived mutagens and 2-acetylaminofluorene by purified rabbit and cDNA expressed human cytochromes P450.
Progress in clinical and biological research 1990;340E():139-47.
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1989: Potenza C L; Pendurthi U R; Strom D K; Tukey R H; Griffin K J; Schwab G E; Johnson E F
Regulation of the rabbit cytochrome P-450 3c gene. Age-dependent expression and transcriptional activation by rifampicin.
The Journal of biological chemistry 1989;264(27):16222-8.
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1989: Johnson E F; Finlayson M; Hujsak C M; Pendurthi U R; Tukey R H
Genetic contributions to the variation among rabbits of liver microsomal deoxycorticosterone synthesis.
Archives of biochemistry and biophysics 1989;273(2):273-80.
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1989: Quattrochi L C; Tukey R H
The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.
Molecular pharmacology 1989;36(1):66-71.
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1987: Okino S T; Quattrochi L C; Pendurthi U R; McBride O W; Tukey R H
Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
The Journal of biological chemistry 1987;262(33):16072-9.
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1987: Johnson E F; Barnes H J; Griffin K J; Okino S; Tukey R H
Characterization of a second gene product related to rabbit cytochrome P-450 1.
The Journal of biological chemistry 1987;262(12):5918-23.
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1987: Johnson E F; Finlayson M; Raucy J; Barnes H; Schwab G E; Griffin K J; Tukey R H
Intraspecies individuality for the metabolism of steroids.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(3):275-85.
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1986: Quattrochi L C; Pendurthi U R; Okino S T; Potenza C; Tukey R H
Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(18):6731-5.
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1985: Tukey R H; Okino S; Barnes H; Griffin K J; Johnson E F
Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1.
The Journal of biological chemistry 1985;260(24):13347-54.
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1985: Quattrochi L C; Okino S T; Pendurthi U R; Tukey R H
Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.
DNA (Mary Ann Liebert, Inc.) 1985;4(5):395-400.
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1985: Okino S T; Quattrochi L C; Barnes H J; Osanto S; Griffin K J; Johnson E F; Tukey R H
Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(16):5310-4.
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