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Denis Bouchard

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Publications

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Nobutaka Suzuki; Shinobu Suzuki; Douglas G Millar; Midori Unno; Hiromitsu Hara; Thomas Calzascia; Sho Yamasaki; Tadashi Yokosuka; Nien-Jung Chen; Alisha R Elford; Jun-Ichiro Suzuki; Arata Takeuchi; Christine Mirtsos; Denis Bouchard; Pamela S Ohashi; Wen-Chen Yeh; Takashi Saito
A critical role for the innate immune signaling molecule IRAK-4 in T cell activation.
Myung-Shin Jeon; Alex Atfield; Venuprasad Poojary; Connie M Krawczyk; Renu Sarao; Chris Elly; Chun Yang; Sudha Arya; Kurt Bachmaier; Leon Su; Denis Bouchard; Russel Jones; Matthew A Gronski; Pamela S Ohashi; Teiji Wada; Debra Bloom; C Garrison Fathman; Yun-Cai Liu; Josef M Penninger
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.
K Farid Ahmad; Ari Melnick; Stuart Lax; Denis Bouchard; Jun Liu; Chih-Li Kiang; Sebastian Mayer; Shinichiro Takahashi; Jonathan D Licht; Gilbert G Privé
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.

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All Publications

2006: Nobutaka Suzuki; Shinobu Suzuki; Douglas G Millar; Midori Unno; Hiromitsu Hara; Thomas Calzascia; Sho Yamasaki; Tadashi Yokosuka; Nien-Jung Chen; Alisha R Elford; Jun-Ichiro Suzuki; Arata Takeuchi; Christine Mirtsos; Denis Bouchard; Pamela S Ohashi; Wen-Chen Yeh; Takashi Saito
A critical role for the innate immune signaling molecule IRAK-4 in T cell activation.
Science (New York, N.Y.) 2006;311(5769):1927-32.
2004: Myung-Shin Jeon; Alex Atfield; Venuprasad Poojary; Connie M Krawczyk; Renu Sarao; Chris Elly; Chun Yang; Sudha Arya; Kurt Bachmaier; Leon Su; Denis Bouchard; Russel Jones; Matthew A Gronski; Pamela S Ohashi; Teiji Wada; Debra Bloom; C Garrison Fathman; Yun-Cai Liu; Josef M Penninger
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.
Immunity 2004;21(2):167-77.
2003: K Farid Ahmad; Ari Melnick; Stuart Lax; Denis Bouchard; Jun Liu; Chih-Li Kiang; Sebastian Mayer; Shinichiro Takahashi; Jonathan D Licht; Gilbert G Privé
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.
Molecular cell 2003;12(6):1551-64.
2003: Nobutaka Suzuki; Shinobu Suzuki; Urs Eriksson; Hiromitsu Hara; Christine Mirtosis; Nien-Jung Chen; Teiji Wada; Denis Bouchard; Irene Hwang; Kiyoshi Takeda; Takashi Fujita; Sandy Der; Josef M Penninger; Shizuo Akira; Takashi Saito; Wen-Chen Yeh
IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6065-71.
2003: Minna Woo; Raza Hakem; Caren Furlonger; Anne Hakem; Gordon S Duncan; Takehiko Sasaki; Denis Bouchard; Liwei Lu; Gillian E Wu; Christopher J Paige; Tak W Mak
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.
Nature immunology 2003;4(10):1016-22.
2003: Tak W Mak; Arda Shahinian; Steven K Yoshinaga; Andrew Wakeham; Lorrie Boucher; Melania Pintilie; Gordon Duncan; Beata U Gajewska; Matthew A Gronski; Urs Eriksson; Bernhard Odermatt; Alexandra Ho; Denis Bouchard; John S Whorisky; Manel Jordana; Pamela S Ohashi; Tony Pawson; Friedhelm Bladt; Anna Tafuri
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses.
Nature immunology 2003;4(8):765-72.
2003: Shinobu Suzuki; Nobutaka Suzuki; Christine Mirtsos; Thomas Horacek; Elizabeth Lye; Seo-Kyu Noh; Alexandra Ho; Denis Bouchard; Tak W Mak; Wen-Chen Yeh
Nur77 as a survival factor in tumor necrosis factor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8276-80.
2003: Nobutaka Suzuki; Nien-Jung Chen; Douglas G Millar; Shinobu Suzuki; Thomas Horacek; Hiromitsu Hara; Denis Bouchard; Kenji Nakanishi; Josef M Penninger; Pamela S Ohashi; Wen-Chen Yeh
IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4031-5.
2003: Leonardo Salmena; Bénédicte Lemmers; Anne Hakem; Elzbieta Matysiak-Zablocki; Kiichi Murakami; P Y Billie Au; Donna M Berry; Laura Tamblyn; Amro Shehabeldin; Eva Migon; Andrew Wakeham; Denis Bouchard; Wen-Chen Yeh; Jane C McGlade; Pamela S Ohashi; Raza Hakem
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.
Genes & development 2003;17(7):883-95.
2002: Malte Peters; Carmela DeLuca; Atsushi Hirao; Vuk Stambolic; Julia Potter; Lily Zhou; Jennifer Liepa; Bryan E Snow; Sudha Arya; Jorge Wong; Denis Bouchard; Richard C Binari; Armen S Manoukian; Tak W Mak
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11305-10.
2001: Sanjeev Mariathasan; Arsen Zakarian; Denis Bouchard; Alison M Michie; Juan Carlos Zúñiga-Pflücker; Pamela S Ohashi
Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):4966-73.
2001: Emily K Griffiths; Connie M Krawczyk; Young-Yun Kong; M Raab; Sharon J Hyduk; Denis Bouchard; Vera S F Chan; Ivona Kozieradzki; Antonio J Oliveira-dos-Santos; Andrew Wakeham; Pamela S Ohashi; Myron I Cybulsky; C E Rudd; Josef M Penninger
Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap.
Science (New York, N.Y.) 2001;293(5538):2260-3.
2001: Jürgen Ruland; Gordon S Duncan; Andrew Elia; I del Barco Barrantes; L Nguyen; Suzanne Plyte; Douglas G Millar; Denis Bouchard; Andrew Wakeham; Pamela S Ohashi; Tak W Mak
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.
Cell 2001;104(1):33-42.
2001: Anna Tafuri; Arda Shahinian; Friedhelm Bladt; Steven K Yoshinaga; Manel Jordana; Andrew Wakeham; Lorrie Boucher; Denis Bouchard; Vera S F Chan; Gordon Duncan; Bernhard Odermatt; Alexandra Ho; Annick Itie; Tom Horan; John S Whoriskey; Tony Pawson; Josef M Penninger; Pamela S Ohashi; Tak W Mak
ICOS is essential for effective T-helper-cell responses.
Nature 2001;409(6816):105-9.
2000: Connie M Krawczyk; Kurt Bachmaier; T Sasaki; Russell G Jones; S B Snapper; Denis Bouchard; Ivona Kozieradzki; Pamela S Ohashi; F W Alt; Josef M Penninger
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells.
Immunity 2000;13(4):463-73.
2000: Takehiko Sasaki; Junko Irie-Sasaki; Y Horie; Kurt Bachmaier; Jimmie E Fata; M Li; Akira Suzuki; Denis Bouchard; Alexandra Ho; Mark Redston; Steven Gallinger; Rama Khokha; Tak W Mak; Phillip T Hawkins; Len Stephens; Stephen W Scherer; May Tsao; Josef M Penninger
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.
Nature 2000;406(6798):897-902.
2000: Tak W Mak; Anne Hakem; John Peter McPherson; Amro Shehabeldin; E Zablocki; Eva Migon; Gordon S Duncan; Denis Bouchard; Andrew Wakeham; A Cheung; Jana Karaskova; Ildiko Sarosi; Jeremy Squire; Jamey D Marth; Raza Hakem
Brca1 required for T cell lineage development but not TCR loci rearrangement.
Nature immunology 2000;1(1):77-82.
2000: Takehiko Sasaki; Junko Irie-Sasaki; Russell G Jones; Antonio J Oliveira-dos-Santos; William L Stanford; B Bolon; Andrew Wakeham; Annick Itie; Denis Bouchard; Ivona Kozieradzki; Nicholas Joza; Tak W Mak; Pamela S Ohashi; Akira Suzuki; Josef M Penninger
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Science (New York, N.Y.) 2000;287(5455):1040-6.
2000: Kurt Bachmaier; Connie M Krawczyk; Ivona Kozieradzki; Young-Yun Kong; Takehiko Sasaki; Antonio J Oliveira-dos-Santos; Sanjeev Mariathasan; Denis Bouchard; Andrew Wakeham; Annick Itie; J Le; Pamela S Ohashi; Ildiko Sarosi; Hiroshi Nishina; Stan Lipkowitz; Josef M Penninger
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
Nature 2000;403(6766):211-6.
1999: Nina Jones; Zubin Master; Jamie Jones; Denis Bouchard; Y Gunji; H Sasaki; R Daly; Kari Alitalo; Daniel J Dumont
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
The Journal of biological chemistry 1999;274(43):30896-905.
1998: Young-Yun Kong; Klaus-Dieter Fischer; Martin F Bachmann; Sanjeev Mariathasan; Ivona Kozieradzki; Mai Nghiem; Denis Bouchard; alan bernstein; Pamela S Ohashi; Josef M Penninger
Vav regulates peptide-specific apoptosis in thymocytes.
The Journal of experimental medicine 1998;188(11):2099-111.
1998: Sanjeev Mariathasan; Martin F Bachmann; Denis Bouchard; Toshiaki Ohteki; Pamela S Ohashi
Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6030-7.
1998: Q Liu; Antonio J Oliveira-dos-Santos; Sanjeev Mariathasan; Denis Bouchard; J Jones; Renu Sarao; Ivona Kozieradzki; Pamela S Ohashi; Josef M Penninger; Daniel J Dumont
The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.
The Journal of experimental medicine 1998;188(7):1333-42.
1998: Richard Boyd; Ivona Kozieradzki; Ann P Chidgey; HW Mittrücker; Denis Bouchard; E Timms; K Kishihara; Christopher J Ong; Daniel Chui; Jamey D Marth; Tak W Mak; Josef M Penninger
Receptor-specific allelic exclusion of TCRV alpha-chains during development.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1718-27.
1998: Bryan E Snow; R A Hall; Andrejs M Krumins; Greg M Brothers; Denis Bouchard; C A Brothers; Stephen Chung; J Mangion; Alfred G Gilman; R J Lefkowitz; David Siderovski
GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
The Journal of biological chemistry 1998;273(28):17749-55.
1998: Klaus-Dieter Fischer; Young-Yun Kong; Hiroshi Nishina; Kerry Tedford; LE Marengère; Ivona Kozieradzki; Takehiko Sasaki; M Starr; G Chan; S Gardener; Mai Nghiem; Denis Bouchard; M Barbacid; alan bernstein; Josef M Penninger
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor.
Current biology : CB 1998;8(10):554-62.
1998: Q Liu; F Shalaby; J Jones; Denis Bouchard; Daniel J Dumont
The SH2-containing inositol polyphosphate 5-phosphatase, ship, is expressed during hematopoiesis and spermatogenesis.
Blood 1998;91(8):2753-9.
1998: H Yoshida; Hiroshi Nishina; H Takimoto; LE Marengère; Andrew Wakeham; Denis Bouchard; Young-Yun Kong; Toshiaki Ohteki; Arda Shahinian; M Bachmann; Pamela S Ohashi; Josef M Penninger; Gerald R Crabtree; Tak W Mak
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.
Immunity 1998;8(1):115-24.
1997: Martin F Bachmann; Sanjeev Mariathasan; Denis Bouchard; DE Speiser; Pamela S Ohashi
Four types of Ca2+ signals in naive CD8+ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists.
European journal of immunology 1997;27(12):3414-9.
1997: Martin F Bachmann; Kim J McKall-Faienza; R Schmits; Denis Bouchard; J Beach; DE Speiser; Tak W Mak; Pamela S Ohashi
Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation.
Immunity 1997;7(4):549-57.
1996: Krassimir Yankulov; M Pandes; Susan McCracken; Denis Bouchard; David L Bentley
TFIIH functions in regulating transcriptional elongation by RNA polymerase II in Xenopus oocytes.
Molecular and cellular biology 1996;16(7):3291-9.
1996: Hans-Willi Mittrücker; Arda Shahinian; Denis Bouchard; TM Kündig; Tak W Mak
Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice.
The Journal of experimental medicine 1996;183(6):2481-8.