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Laurence Turka

Research Profile

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Anatomy

Physiology

Chemicals & Drugs

Procedures

Transplantation, Homologous

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Publications

TOP 3
Alexandria Huynh; Laurence A Turka
Control of T cell tolerance by phosphatase and tensin homolog.
Jihoon Chang; Vijay K Kuchroo; Laurence A Turka; Christopher M Borges; Patrick R Burkett; Cheong-Hee Chang
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Ruan Zhang; Gregory Whitcher; Jihoon Chang; Alexandria Huynh; Jonathan S Maltzman; Laurence A Turka
An obligate cell-intrinsic function for CD28 in Tregs.

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All Publications

2013: Alexandria Huynh; Laurence A Turka
Control of T cell tolerance by phosphatase and tensin homolog.
Annals of the New York Academy of Sciences 2013;1280():27-9.
2013: Jihoon Chang; Vijay K Kuchroo; Laurence A Turka; Christopher M Borges; Patrick R Burkett; Cheong-Hee Chang
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(6):2270-5.
2013: Ruan Zhang; Gregory Whitcher; Jihoon Chang; Alexandria Huynh; Jonathan S Maltzman; Laurence A Turka
An obligate cell-intrinsic function for CD28 in Tregs.
The Journal of clinical investigation 2013;123(2):580-93.
2012: Guy W Scadding; Alkis Togias; Laurence A Turka; Virginia Bellido; Moises A Calderon; Stephen R Durham; Trevor T Hansel; Gitte Konsgaard Koed; Kaare Lund; Niels-Christian Nielsen; Deborah Phippard; Peter Adler Wurtzen
Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes.
Journal of immunological methods 2012;384(1-2):25-32.
2012: Aisling O'Hara Hall; Tajie Harris; Daniel P Beiting; Yasmine Belkaid; Nicolas Bouladoux; Sara Cherry; Daniel J Cua; M Merle Elloso; John Grainger; Beena John; Claudia Gonzalez Lombana; Guillaume Oldenhove; Gretchen Harms Pritchard; Steven L Reiner; David S Roos; Philip Scott; Jonathan S Silver; Jason S Stumhofer; Cristina M Tato; Laurence A Turka; Sagie Wagage; Elia D Tait Wojno; Christopher A Hunter
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity 2012;37(3):511-23.
2012: S Alice Long; Deborah Phippard; Alex Rabinovitch; Mary Rieck; Peter L Samuels; Srinath Sanda; Laurence A Turka; Steven A Adah; Sudeepta Aggarwal; Andrew Ahmann; Peter J Bianchine; Jeffrey A Bluestone; Jennifer B Bollyky; Karen D Boyle; Jane H Buckner; Mario R Ehlers; Robin Goland; Carla J Greenbaum
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function.
Diabetes 2012;61(9):2340-8.
2012: Shipra Gupta; Vijay K Kuchroo; Rafael Larocca; Thomas B Thornley; Laurence A Turka; Wenda Gao; Terry B Strom
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.
The Journal of clinical investigation 2012;122(7):2395-404.
2012: John E Harris; Tajie H Harris; Christopher A Hunter; Wolfgang Weninger; E John Wherry; Laurence A Turka
A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin.
The Journal of investigative dermatology 2012;132(7):1869-76.
2012: Scott M Lieberman; Jonathan S Maltzman; Edward M Behrens; Evann Corbo-Rodgers; Taku Kambayashi; Jiyeon S Kim; Laurence A Turka
Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer.
European journal of immunology 2012;42(6):1429-35.
2012: N K Tchao; Laurence A Turka
Lymphodepletion and homeostatic proliferation: implications for transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(5):1079-90.
2012: Lynn D Haynes; M P Hernandez-Fuentes; Ewa Jankowska-Gan; M R Keller; R I Lechler; K A Newell; V Seyfert-Margolis; A Sheka; Laurence A Turka; William J Burlingham
Donor-specific indirect pathway analysis reveals a B-cell-independent signature which reflects outcomes in kidney transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(3):640-8.
2012: Laurence A Turka
Plus ça change, plus c'est la même chose.
The Journal of clinical investigation 2012;122(2):422-3.
2012: Sandy Feng; David Ikle; Steven J Lobritto; Mary C Philogene; Katharine M Poole; John P Roberts; Philip Rosenthal; Estella M Alonso; Nancy D Bridges; Anthony J Demetris; Udeme D Ekong; Laurence A Turka; Nadia K Tchao
Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants.
JAMA : the journal of the American Medical Association 2012;307(3):283-93.
2012: Ryan H Newton; Laurence A Turka
Regulation of T cell homeostasis and responses by pten.
Frontiers in immunology 2012;3():151.
2012: X Zhao; O Boenisch; John Iacomini; B Mfarrej; Mohamed H Sayegh; Laurence A Turka; Sunmi Yang; M Yeung; Xueli Yuan
Critical role of proinflammatory cytokine IL-6 in allograft rejection and tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(1):90-101.
2011: Kenneth A Newell; Deborah Phippard; Laurence A Turka
Regulatory cells and cell signatures in clinical transplantation tolerance.
Current opinion in immunology 2011;23(5):655-9.
2011: David J Friedman; Laurence A Turka; Simon C Robson
There's a goat behind door number 3: from Monty Hall to medicine.
The Journal of clinical investigation 2011;121(10):3819-21.
2011: Hugh Auchincloss; Laurence A Turka
CTLA-4: not all costimulation is stimulatory.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3457-8.
2011: Wayne W Hancock; Laurence A Turka
Immunogenetics and transplantation.
Current opinion in immunology 2011;23(5):639-40.
2011: Adam G Schrum; Laurence A Turka; Diana Gil; Ed Palmer
Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):870-8.
2011: Laurence A Turka; Arthur Caplan
What is the evidence for our standards of care?
The Journal of clinical investigation 2011;121(7):2530.
2011: Elia D Tait Wojno; Qun Fang; Nancy Hosken; Steven D Levin; Elizabeth Mauldin; Aisling C O'Hara; Jason S Stumhofer; Laurence A Turka; Christopher A Hunter
A role for IL-27 in limiting T regulatory cell populations.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):266-73.
2011: Gerald Nepom; E William St Clair; Laurence A Turka
Challenges in the pursuit of immune tolerance.
Immunological reviews 2011;241(1):49-62.
2011: Shaun P Murphy; Paige M Porrett; Laurence A Turka
Innate immunity in transplant tolerance and rejection.
Immunological reviews 2011;241(1):39-48.
2011: Adeeb Rahman; Ruan Zhang; Christopher D Blosser; Baidong Hou; Anthony L Defranco; Jonathan S Maltzman; E John Wherry; Laurence A Turka
Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88.
Blood 2011;117(11):3123-30.
2010: Jeffrey A Bluestone; Hugh Auchincloss; Gerald Nepom; Daniel Rotrosen; E William St Clair; Laurence A Turka
The Immune Tolerance Network at 10 years: tolerance research at the bedside.
Nature reviews. Immunology 2010;10(11):797-803.
2010: Xian Chang Li; Laurence A Turka
An update on regulatory T cells in transplant tolerance and rejection.
Nature reviews. Nephrology 2010;6(10):577-83.
2010: Francesca D'Addio; Xueli Yuan; Antje Habicht; John Williams; Melanie Ruzek; John Iacomini; Laurence A Turka; Mohamed H Sayegh; Nader Najafian; Mohammed Javeed I Ansari
A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model.
Transplantation 2010;90(3):260-9.
2010: Laurence A Turka; Kathryn Wood; Jeffrey A Bluestone
Bringing transplantation tolerance into the clinic: lessons from the ITN and RISET for the Establishment of Tolerance consortia.
Current opinion in organ transplantation 2010;15(4):441-8.
2010: Xiaohe Liu; Jodi L Karnell; Bu Yin; Ruan Zhang; Jidong Zhang; Peiying Li; Yongwon Choi; Jonathan S Maltzman; Warren S Pear; Craig H Bassing; Laurence A Turka
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.
The Journal of clinical investigation 2010;120(7):2497-507.
2010: Pedro J Cejas; Matthew C Walsh; Erika L Pearce; Daehee Han; Gretchen M Harms; David Artis; Laurence A Turka; Yongwon Choi
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.
Blood 2010;115(23):4750-7.
2010: Kenneth A Newell; Adam Asare; Allan D Kirk; Trang D Gisler; Kasia Bourcier; Manikkam Suthanthiran; William J Burlingham; William H Marks; Ignacio Sanz; Robert I Lechler; Maria P Hernandez-Fuentes; Laurence A Turka; Vicki L Seyfert-Margolis
Identification of a B cell signature associated with renal transplant tolerance in humans.
The Journal of clinical investigation 2010;120(6):1836-47.
2010: Jeffrey A Bluestone; Alan M Krensky; Laurence A Turka; Daniel Rotrosen; Jeffrey B Matthews
Ten years of the Immune Tolerance Network: an integrated clinical research organization.
Science translational medicine 2010;2(19):19cm7.
2010: Hilda E Ramón; Pedro J Cejas; David F Larosa; Adeeb Rahman; John E Harris; Jidong Zhang; Christopher Hunter; Yongwon Choi; Laurence A Turka
EGR-2 is not required for in vivo CD4 T cell mediated immune responses.
PloS one 2010;5(9):e12904.
2009: J Yang; L V Riella; O Boenisch; Joyce Popoola; S Robles; T Watanabe; V Vanguri; Xueli Yuan; Indira Guleria; Laurence A Turka; Mohamed H Sayegh; Anil Chandraker
Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(12):2837-44.
2009: Jonathan A Epstein; Laurence A Turka; Morris Birnbaum; Gary Koretzky
The physician's voice in the health care debate.
The Journal of clinical investigation 2009;119(10):2846.
2009: Laurence A Turka
Top priority.
The Journal of clinical investigation 2009;119(9):2436-7.
2009: Laurence A Turka; Robert I Lechler
Towards the identification of biomarkers of transplantation tolerance.
Nature reviews. Immunology 2009;9(7):521-6.
2009: Xueli Yuan; Mohammed Javeed I Ansari; Francesca D'Addio; Jesus Paez-Cortez; Isabella Schmitt; Michela Donnarumma; Olaf Boenisch; Xiaozhi Zhao; Joyce Popoola; Michael R Clarkson; Hideo Yagita; Hisaya Akiba; Gordon J Freeman; John Iacomini; Laurence A Turka; Laurie H Glimcher; Mohamed H Sayegh
Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10734-9.
2009: Laurence A Turka
After further review.
The Journal of clinical investigation 2009;119(5):1057.
2009: Adeeb Rahman; D K Taylor; Laurence A Turka
The contribution of direct TLR signaling to T cell responses.
Immunologic research 2009;45(1):25-36.
2008: Eric J Allenspach; Maria P Lemos; Paige M Porrett; Laurence A Turka; Tom Li Stephen
Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells.
Immunity 2008;29(5):795-806.
2008: Ushma S Neill; Laurence A Turka
Bothered and bewildered, but not bewitched.
The Journal of clinical investigation 2008;118(11):3516.
2008: Adeeb Rahman; Weiguo Cui; David F Larosa; D K Taylor; Jidong Zhang; Daniel R Goldstein; E John Wherry; Susan M Kaech; Laurence A Turka
MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):3804-10.
2008: Laurence A Turka
Senator, what is your policy on "Other"?
The Journal of clinical investigation 2008;118(9):2988.
2008: Jodi L Buckler; Xiaohe Liu; Laurence A Turka
Regulation of T-cell responses by PTEN.
Immunological reviews 2008;224():239-48.
2008: Vicki Seyfert-Margolis; Laurence A Turka
Marking a path to transplant tolerance.
The Journal of clinical investigation 2008;118(8):2684-6.
2008: Paige M Porrett; Xueli Yuan; David F Larosa; patrick walsh; Jaeseok Yang; Wenda Gao; Peiying Li; Jidong Zhang; Javeed M Ansari; Wayne W Hancock; Mohamed H Sayegh; Maria Koulmanda; Terry B Strom; Laurence A Turka
Mechanisms underlying blockade of allograft acceptance by TLR ligands.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1692-9.
2008: Birgit Sawitzki; Petra Reinke; Hans-Dieter Volk; Kathryn Wood; Laurence A Turka
Autoimmunity and transplantation: a meeting at the crossroads in Berlin.
Nature immunology 2008;9(5):447-9.
2008: David F Larosa; Jason S Stumhofer; Andrew E Gelman; Adeeb Rahman; D K Taylor; Christopher A Hunter; Laurence A Turka
T cell expression of MyD88 is required for resistance to Toxoplasma gondii.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3855-60.
2008: Laurence A Turka
Animal house.
The Journal of clinical investigation 2008;118(3):822.
2008: Takuya Ueno; Antje Habicht; Michael R Clarkson; Monica J Albin; Kazuhiro Yamaura; Olaf Boenisch; Joyce Popoola; Ying Wang; Hideo Yagita; Hisaya Akiba; Mohammed Javeed I Ansari; Jaeseok Yang; Laurence A Turka; David M Rothstein; Robert F Padera; Nader Najafian; Mohamed H Sayegh
The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.
The Journal of clinical investigation 2008;118(2):742-51.
2008: Carolyn G King; Jodi L Buckler; Takashi Kobayashi; Jeffrey R Hannah; Garrett Bassett; Taesoo Kim; Erika L Pearce; Gregory G Kim; Laurence A Turka; Yongwon Choi
Cutting edge: requirement for TRAF6 in the induction of T cell anergy.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):34-8.
2008: Laurence A Turka; patrick walsh
IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells.
Frontiers in bioscience : a journal and virtual library 2008;13():1440-6.
2007: Jaeseok Yang; Matthew O Brook; Manuela Carvalho-Gaspar; Jidong Zhang; Hilda E Ramon; Mohamed H Sayegh; Kathryn J Wood; Laurence A Turka; Nick D Jones
Allograft rejection mediated by memory T cells is resistant to regulation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19954-9.
2007: Jason S Stumhofer; Jonathan S Silver; Arian Dominic John laurence; Paige M Porrett; Tajie Harris; Laurence A Turka; Matthias Ernst; Christiaan J M Saris; John O'Shea; Christopher A Hunter
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.
Nature immunology 2007;8(12):1363-71.
2007: Ran Tao; Edwin de Zoeten; Engin Ozkaynak; Chunxia Chen; Liqing Wang; Paige M Porrett; Bin Li; Laurence A Turka; Eric N Olson; Mark I Greene; Andrew D Wells; Wayne W Hancock
Deacetylase inhibition promotes the generation and function of regulatory T cells.
Nature medicine 2007;13(11):1299-307.
2007: Florence Dzierszinski; Marion Pepper; Jason S Stumhofer; David F Larosa; Emma H Wilson; Laurence A Turka; Sandra K Halonen; Christopher A Hunter; David S Roos
Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells.
Infection and immunity 2007;75(11):5200-9.
2007: Laurence A Turka
Lost in a dark wood.
The Journal of clinical investigation 2007;117(7):1734-5.
2007: David F Larosa; Adeeb Rahman; Laurence A Turka
The innate immune system in allograft rejection and tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7503-9.
2007: Adam Schrum; Diana Gil; Elaine P Dopfer; David L. Wiest; Laurence A Turka; Wolfgang W A Schamel; Ed Palmer
High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry.
Science's STKE : signal transduction knowledge environment 2007;2007(389):pl2.
2007: Jonathan S Maltzman; Laurence A Turka
Conditional gene expression: a new tool for the transplantologist.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(4):733-40.
2007: David F Larosa; Andrew E Gelman; Adeeb Rahman; Jidong Zhang; Laurence A Turka; patrick walsh
CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells.
Immunology letters 2007;108(2):183-8.
2006: Andrew E Gelman; David F Larosa; Jidong Zhang; patrick walsh; Yongwon Choi; J Oriol Sunyer; Laurence A Turka
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation.
Immunity 2006;25(5):783-93.
2006: Jodi L Buckler; patrick walsh; Paige M Porrett; Yongwon Choi; Laurence A Turka
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4262-6.
2006: Carolyn G King; Takashi Kobayashi; Pedro J Cejas; Taesoo Kim; Kwiyeom Yoon; Gregory K Kim; Elise Chiffoleau; Somia P Hickman; patrick walsh; Laurence A Turka; Yongwon Choi
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis.
Nature medicine 2006;12(9):1088-92.
2006: patrick walsh; Jodi L Buckler; Jidong Zhang; Andrew E Gelman; Nicole M Dalton; D K Taylor; Steven J Bensinger; Wayne W Hancock; Laurence A Turka
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs.
The Journal of clinical investigation 2006;116(9):2521-31.
2006: D K Taylor; patrick walsh; David F Larosa; Jidong Zhang; Matthew Burchill; Michael A Farrar; Laurence A Turka
Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2216-23.
2006: Somia P Hickman; Jaeseok Yang; Rajan M Thomas; Andrew D Wells; Laurence A Turka
Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2186-94.
2006: Ariela Benigni; Susanna Tomasoni; Laurence A Turka; Lorena Longaretti; Lorena Zentilin; Marilena Mister; Anna Pezzotta; Nadia Azzollini; Marina Noris; Sara Conti; Mauro Abbate; Mauro Giacca; Giuseppe Remuzzi
Adeno-associated virus-mediated CTLA4Ig gene transfer protects MHC-mismatched renal allografts from chronic rejection.
Journal of the American Society of Nephrology : JASN 2006;17(6):1665-72.
2006: David Neujahr; Chuangqi Chen; Xiaolun Huang; James F Markmann; Stephen Cobbold; Herman Waldmann; Mohamed H Sayegh; Wayne W Hancock; Laurence A Turka
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4632-9.
2006: Jeffrey A Bluestone; E William St Clair; Laurence A Turka
CTLA4Ig: bridging the basic immunology with clinical application.
Immunity 2006;24(3):233-8.
2006: patrick walsh; Bernice M Benoit; Maria Wysocka; Nicole M Dalton; Laurence A Turka; Alain H Rook
A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection.
The Journal of investigative dermatology 2006;126(3):690-2.
2006: Minh Diem Vu; Michael R Clarkson; Hideo Yagita; Laurence A Turka; Mohamed H Sayegh; Xian Chang Li
Critical, but conditional, role of OX40 in memory T cell-mediated rejection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1394-401.
2006: Alberto Sánchez-Fueyo; Sigrid E Sandner; Antje Habicht; Christophe Mariat; James Kenny; Nicolas Degauque; Xin Xiao Zheng; Terry B Strom; Laurence A Turka; Mohamed H Sayegh
Specificity of CD4+CD25+ regulatory T cell function in alloimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):329-34.
2005: Aaron K Neumann; Jaeseok Yang; Mangatt P Biju; Suresh K Joseph; Randall S Johnson; Volker H Haase; Bruce D Freedman; Laurence A Turka
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17071-6.
2005: Alexander S Krupnick; Andrew E Gelman; Winfried Barchet; Steve Richardson; Friederike H Kreisel; Laurence A Turka; Marco COLONna; G Alexander Patterson; Daniel Kreisel
Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6265-70.
2005: Somia P Hickman; Laurence A Turka
Homeostatic T cell proliferation as a barrier to T cell tolerance.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1461):1713-21.
2005: Robert I Lechler; Megan Sykes; Angus W Thomson; Laurence A Turka
Organ transplantation--how much of the promise has been realized?
Nature medicine 2005;11(6):605-13.
2005: Soren Schenk; Danielle D Kish; Chunshui He; Tarek el-Sawy; Eise Chiffoleau; Chuangqi Chen; Chuangqui Chen; Zihao Wu; Sigrid Sandner; Anton V Gorbachev; Kiyotaka Fukamachi; Peter S Heeger; Mohamed H Sayegh; Laurence A Turka; Robert L Fairchild
Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3741-8.
2005: Sigrid E Sandner; Michael R Clarkson; Alan D Salama; Alberto Sanchez-Fueyo; Christoph Domenig; Antje Habicht; Nader Najafian; Hideo Yagita; Miyuki Azuma; Laurence A Turka; Mohamed H Sayegh
Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3408-15.
2005: Adam Schrum; Ed Palmer; Laurence A Turka
Distinct temporal programming of naive CD4+ T cells for cell division versus TCR-dependent death susceptibility by antigen-presenting macrophages.
European journal of immunology 2005;35(2):449-59.
2005: Sigrid E Sandner; Michael R Clarkson; Alan D Salama; Alberto Sanchez-Fueyo; Hideo Yagita; Laurence A Turka; Mohamed H Sayegh
Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(1):31-9.
2005: David Neujahr; Laurence A Turka
Lymphocyte depletion as a barrier to immunological tolerance.
Contributions to nephrology 2005;146():65-72.
2004: Alden M Doyle; Robert I Lechler; Laurence A Turka
Organ transplantation: halfway through the first century.
Journal of the American Society of Nephrology : JASN 2004;15(12):2965-71.
2004: patrick walsh; D K Taylor; Laurence A Turka
Tregs and transplantation tolerance.
The Journal of clinical investigation 2004;114(10):1398-403.
2004: Mangatt P Biju; Aaron K Neumann; Steven J Bensinger; Randall S Johnson; Laurence A Turka; Volker H Haase
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes.
Molecular and cellular biology 2004;24(20):9038-47.
2004: D K Taylor; David Neujahr; Laurence A Turka
Heterologous immunity and homeostatic proliferation as barriers to tolerance.
Current opinion in immunology 2004;16(5):558-64.
2004: Daniel Kreisel; Alyssa M Krasinskas; Alexander S Krupnick; Andrew E Gelman; Keki R Balsara; Sicco Popma; Markus Riha; ARIELLA ROSENGARD; Laurence A Turka; Bruce R Rosengard
Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3027-34.
2004: Andrew E Gelman; Jidong Zhang; Yongwon Choi; Laurence A Turka
Toll-like receptor ligands directly promote activated CD4+ T cell survival.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6065-73.
2004: Steven J Bensinger; patrick walsh; Jidong Zhang; Martin Carroll; Ramon Parsons; Jeffrey C Rathmell; Craig Thompson; Matthew Burchill; Michael A Farrar; Laurence A Turka
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5287-96.
2004: patrick walsh; Terry B Strom; Laurence A Turka
Routes to transplant tolerance versus rejection; the role of cytokines.
Immunity 2004;20(2):121-31.
2004: Marielena Mata; Elise Chiffoleau; Scott H Adler; Tynua Gray; Wayne Hancock; Laurence A Turka
Bcl-XL expression in stem cells facilitates engraftment and reduces the need for host conditioning during bone marrow transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(1):58-64.
2004: Zihao Wu; Steven J Bensinger; Jidong Zhang; Chuangqi Chen; Xueli Yuan; Xiaolun Huang; James F Markmann; Alireza Kassaee; Bruce R Rosengard; Wayne W Hancock; Mohamed H Sayegh; Laurence A Turka
Homeostatic proliferation is a barrier to transplantation tolerance.
Nature medicine 2004;10(1):87-92.
2003: Andrew E Gelman; Laurence A Turka
Autoimmunity heats up.
Nature medicine 2003;9(12):1465-6.
2003: Matthew Burchill; Christine A Goetz; Martin Prlic; Jennifer J O'Neil; Ian R Harmon; Steven J Bensinger; Laurence A Turka; Paul Brennan; Stephen C Jameson; Michael A Farrar
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5853-64.
2003: Elise Chiffoleau; Takashi Kobayashi; Matthew C Walsh; Carolyn G King; patrick walsh; Wayne W Hancock; Yongwon Choi; Laurence A Turka
TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5751-9.
2003: Adam Schrum; Laurence A Turka; Ed Palmer
Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.
Immunological reviews 2003;196():7-24.
2003: Sigrid E Sandner; Alan D Salama; Stuart L Houser; Ed Palmer; Laurence A Turka; Mohamed H Sayegh
New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(10):1242-50.
2003: Scott H Adler; Elise Chiffoleau; Lanwei Xu; Nicole M Dalton; Jennifer M Burg; Andrew D Wells; Michael S Wolfe; Laurence A Turka; Warren S Pear
Notch signaling augments T cell responsiveness by enhancing CD25 expression.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):2896-903.
2003: Takashi Kobayashi; patrick walsh; Matthew C Walsh; Kendra M Speirs; Elise Chiffoleau; Carolyn G King; Wayne W Hancock; Jorge H Caamano; Christopher A Hunter; Phillip Scott; Laurence A Turka; Yongwon Choi
TRAF6 is a critical factor for dendritic cell maturation and development.
Immunity 2003;19(3):353-63.
2003: James B Chung; Andrew D Wells; Scott Adler; Anand Jacob; Laurence A Turka; John G Monroe
Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1758-67.
2003: Josef Kurtz; Ariadne Lie; Mathew Griffith; Shannon Eysaman; Juanita Shaffer; Natalie Anosova; Laurence A Turka; Gilles Benichou; Megan Sykes
Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(7):804-16.
2003: Elise Chiffoleau; patrick walsh; Laurence A Turka
Apoptosis and transplantation tolerance.
Immunological reviews 2003;193():124-45.
2003: Andrew D Wells; Qing-Hua Liu; Brian Hondowicz; Jidong Zhang; Laurence A Turka; Bruce D Freedman
Regulation of T cell activation and tolerance by phospholipase C gamma-1-dependent integrin avidity modulation.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4127-33.
2003: Mohamed H Sayegh; Zihao Wu; Wayne W Hancock; Peter B Langmuir; Marielena Mata; Sigrid E Sandner; Koji Kishimoto; Masayuki Sho; Ed Palmer; Richard N Mitchell; Laurence A Turka
Allograft rejection in a new allospecific CD4+ TCR transgenic mouse.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(4):381-9.
2003: Robert I Lechler; Oliver A Garden; Laurence A Turka
The complementary roles of deletion and regulation in transplantation tolerance.
Nature reviews. Immunology 2003;3(2):147-58.
2002: Daniel Kreisel; Alexander S Krupnick; Keki R Balsara; Markus Riha; Andrew E Gelman; Sicco Popma; Wilson Y Szeto; Laurence A Turka; Bruce R Rosengard
Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6154-61.
2002: Qing-Hua Liu; Bernd K Fleischmann; Brian Hondowicz; Curtis C Maier; Laurence A Turka; Katsuyuki Yui; Michael I Kotlikoff; Andrew D Wells; Bruce D Freedman
Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation.
The Journal of experimental medicine 2002;196(7):897-909.
2002: Scott H Adler; Laurence A Turka
Immunotherapy as a means to induce transplantation tolerance.
Current opinion in immunology 2002;14(5):660-5.
2002: Alexander S Krupnick; Daniel Kreisel; Sicco Popma; Keki R Balsara; Wilson Y Szeto; Alyssa M Krasinskas; Markus Riha; Andrew D Wells; Laurence A Turka; Bruce R Rosengard
Mechanism of T cell-mediated endothelial apoptosis.
Transplantation 2002;74(6):871-6.
2002: Adam Schrum; Laurence A Turka
The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering.
The Journal of experimental medicine 2002;196(6):793-803.
2002: Robert I Lechler; Megan Sykes; Angus W Thomson; Laurence A Turka
Designer meetings.
Nature immunology 2002;3(9):791.
2002: Koji Kishimoto; Sigrid E Sandner; Jaime Imitola; Masayuki Sho; Yongsheng Li; Peter B Langmuir; David M Rothstein; Terry B Strom; Laurence A Turka; Mohamed H Sayegh
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance.
The Journal of clinical investigation 2002;109(11):1471-9.
2002: Su-jean Seo; Michele L Fields; Jodi L Buckler; Amy J Reed; Laura Mandik-Nayak; Simone A Nish; Randolph J Noelle; Laurence A Turka; Fred D Finkelman; Andrew J Caton; Jan Erikson
The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells.
Immunity 2002;16(4):535-46.
2002: Yasuhiko Makino; Donald N Cook; Oliver Smithies; Olivia Y Hwang; Eric G Neilson; Laurence A Turka; Hiroshi Sato; Andrew D Wells; Theodore M Danoff
Impaired T cell function in RANTES-deficient mice.
Clinical immunology (Orlando, Fla.) 2002;102(3):302-9.
2002: Daniel Kreisel; Alexander S Krupnick; Andrew E Gelman; Friederike H Engels; Sicco Popma; Alyssa M Krasinskas; Keki R Balsara; Wilson Y Szeto; Laurence A Turka; Bruce R Rosengard
Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition.
Nature medicine 2002;8(3):233-9.
2002: Daniel Kreisel; David Sankaran; Andrew D Wells; Laurence A Turka
Interleukin-2-mediated survival and proliferative signals are uncoupled in T lymphocytes that fail to divide after activation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(2):120-8.
2002: Scott H Adler; Steven J Bensinger; Laurence A Turka
Stemming the tide of rejection.
Nature medicine 2002;8(2):107-8.
2001: Xian Chang Li; A D Wells; Laurence A Turka; Terry B Strom
Death of alloreactive T cells sets the stage for immunoregulation to act.
Transplantation proceedings 2001;33(7-8):3041-3.
2001: H Gudmundsdottir; Laurence A Turka
A closer look at homeostatic proliferation of CD4+ T cells: costimulatory requirements and role in memory formation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3699-707.
2001: Andrew D Wells; Matthew C Walsh; J A Bluestone; Laurence A Turka
Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy.
The Journal of clinical investigation 2001;108(6):895-903.
2001: Akira Yamada; Koji Kishimoto; Victor M Dong; Masayuki Sho; Alan D Salama; Natalie Anosova; Gilles Benichou; Didier A Mandelbrot; Arlene H Sharpe; Laurence A Turka; Hugh Auchincloss; Mohamed H Sayegh
CD28-independent costimulation of T cells in alloimmune responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):140-6.
2001: Andrew D Wells; X C Li; T B Strom; Laurence A Turka
The role of peripheral T-cell deletion in transplantation tolerance.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):617-23.
2001: Xian Chang Li; Terry B Strom; Laurence A Turka; A D Wells
T cell death and transplantation tolerance.
Immunity 2001;14(4):407-16.
2001: Steven C Eck; Laurence A Turka
Adoptive transfer enables tumor rejection targeted against a self-antigen without the induction of autoimmunity.
Cancer research 2001;61(7):3077-83.
2001: K S Kim; Mark D Denton; Anil Chandraker; A Knoflach; R Milord; Ana Maria Waaga; Laurence A Turka; M E Russell; Robert Peach; Mohamed H Sayegh
CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis.
The American journal of pathology 2001;158(3):977-86.
2001: Thomas Wekerle; Josef Kurtz; Mohamed H Sayegh; Hiroshi Ito; A Wells; S Bensinger; Juanita Shaffer; Laurence A Turka; Megan Sykes
Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2311-6.
2001: E J Suchin; Peter B Langmuir; Ed Palmer; Mohamed H Sayegh; Andrew D Wells; Laurence A Turka
Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):973-81.
2001: Bruce R Rosengard; Laurence A Turka
The tolerant recipient: looking great in someone else's genes.
The Journal of clinical investigation 2001;107(1):33-4.
2000: Andrew D Wells; Matthew C Walsh; David Sankaran; Laurence A Turka
T cell effector function and anergy avoidance are quantitatively linked to cell division.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2432-43.
2000: Adam Schrum; Andrew D Wells; Laurence A Turka
Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation.
International immunology 2000;12(6):833-42.
2000: S Issazadeh; Kald A Abdallah; Tanuja Chitnis; Anil Chandraker; A D Wells; Laurence A Turka; Mohamed H Sayegh; Samia J Khoury
Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis.
The Journal of clinical investigation 2000;105(8):1109-16.
2000: H Gudmundsdottir; Laurence A Turka
Transplantation tolerance: mechanisms and strategies?
Seminars in nephrology 2000;20(2):209-16.
1999: Andrew D Wells; X C Li; Yong Li; Matthew C Walsh; X X Zheng; Zihao Wu; G Nuñez; A Tang; Mohamed H Sayegh; Wayne W Hancock; T B Strom; Laurence A Turka
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.
Nature medicine 1999;5(11):1303-7.
1999: Steven C Eck; Laurence A Turka
Generation of protective immunity against an immunogenic carcinoma requires CD40/CD40L and B7/CD28 interactions but not CD4(+) T cells.
Cancer immunology, immunotherapy : CII 1999;48(6):336-41.
1999: ARIELLA ROSENGARD; L C Alonso; LC Korb; William M Baldwin; Alfred P. Sanfilippo; Laurence A Turka; Joseph M Ahearn
Functional characterization of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP).
Molecular immunology 1999;36(10):685-97.
1999: H Gudmundsdottir; Laurence A Turka
T cell costimulatory blockade: new therapies for transplant rejection.
Journal of the American Society of Nephrology : JASN 1999;10(6):1356-65.
1999: H Gudmundsdottir; Andrew D Wells; Laurence A Turka
Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5212-23.
1999: TA Judge; Zihao Wu; XG Zheng; A H Sharpe; Mohamed H Sayegh; Laurence A Turka
The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):1947-51.
1999: A Wells; H Gudmundsdottir; M Walsh; Laurence A Turka
Single-cell analysis of T-cell responses in vitro and in vivo: role of costimulatory signals.
Transplantation proceedings 1999;31(1-2):814-5.
1998: JP Vella; Mohamed H Sayegh; Laurence A Turka
Developments in the clinical science of transplantation during the 20th century.
Pediatric transplantation 1998;2(4):257-62.
1998: T A Judge; Niraj Desai; Z Yang; Susan Y Rostami; L Alonso; H Zhang; Y Chen; J F Markman; R P DeMateo; Clyde F Barker; Ali Naji; Laurence A Turka
Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival.
Transplantation 1998;66(4):426-34.
1998: XG Zheng; Laurence A Turka
Blocking T-cell costimulation to prevent transplant rejection.
Transplantation proceedings 1998;30(5):2146-9.
1998: H K Boxhorn; JG Smith; Y J Chang; DuPont Guerry; William M F Lee; U Rodeck; Laurence A Turka; Stephen L Eck
Adenoviral transduction of melanoma cells with B7-1: antitumor immunity and immunosuppressive factors.
Cancer immunology, immunotherapy : CII 1998;46(5):283-92.
1998: Mohamed H Sayegh; Laurence A Turka
The role of T-cell costimulatory activation pathways in transplant rejection.
The New England journal of medicine 1998;338(25):1813-21.
1998: Laurence A Turka
What's new in transplant immunology: problems and prospects.
Annals of internal medicine 1998;128(11):946-8.
1998: Meike Schaub; Thomas H W Stadlbauer; Anil Chandraker; JP Vella; Laurence A Turka; Mohamed H Sayegh
Comparative strategies to induce long-term graft acceptance in fully allogeneic renal versus cardiac allograft models by CD28-B7 T cell costimulatory blockade: role of thymus and spleen.
Journal of the American Society of Nephrology : JASN 1998;9(5):891-8.
1998: K Jooss; Laurence A Turka; James M Wilson
Blunting of immune responses to adenoviral vectors in mouse liver and lung with CTLA4Ig.
Gene therapy 1998;5(3):309-19.
1998: Kim M Olthoff; TA Judge; Andrew E Gelman; X da Shen; Wayne W Hancock; Laurence A Turka; Abraham Shaked
Adenovirus-mediated gene transfer into cold-preserved liver allografts: survival pattern and unresponsiveness following transduction with CTLA4Ig.
Nature medicine 1998;4(2):194-200.
1997: Mohamed H Sayegh; X G Zheng; Colm Magee; Wayne W Hancock; Laurence A Turka
Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients.
Transplantation 1997;64(12):1646-50.
1997: Andrew D Wells; H Gudmundsdottir; Laurence A Turka
Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.
The Journal of clinical investigation 1997;100(12):3173-83.
1997: A Tang; TA Judge; Laurence A Turka
Blockade of CD40-CD40 ligand pathway induces tolerance in murine contact hypersensitivity.
European journal of immunology 1997;27(12):3143-50.
1997: Steven C Eck; D Chang; Andrew D Wells; Laurence A Turka
Differential down-regulation of CD28 by B7-1 and B7-2 engagement.
Transplantation 1997;64(10):1497-9.
1997: L Gallon; Anil Chandraker; S Issazadeh; Robert Peach; Peter Linsley; Laurence A Turka; Mohamed H Sayegh; Samia J Khoury
Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4212-6.
1997: Hongtao Zhang; Y Yang; JL Horton; EB Samoilova; T A Judge; Laurence A Turka; James M Wilson; Youhai Chen
Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.
The Journal of clinical investigation 1997;100(8):1951-7.
1997: Xin Xiao Zheng; Mohamed H Sayegh; X G Zheng; Yongsheng Li; Peter Linsley; Robert Peach; F Borriello; Terry B Strom; A H Sharpe; Laurence A Turka
The role of donor and recipient B7-1 (CD80) in allograft rejection.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1169-73.
1997: S Aradhye; Laurence A Turka
Will tolerance become a clinical reality?
The American journal of the medical sciences 1997;313(5):310-4.
1997: Enver Akalin; Anil Chandraker; Mohamed H Sayegh; Laurence A Turka
Role of the CD28:B7 costimulatory interaction in alloimmune responses.
Kidney international. Supplement 1997;58():S8-10.
1997: Kim M Olthoff; X Da Chen; Andrew E Gelman; Laurence A Turka; Abraham Shaked
Adenovirus-mediated gene transfer of CTLA4Ig to liver allografts results in prolonged survival and local T-cell anergy.
Transplantation proceedings 1997;29(1-2):1030-1.
1996: Enver Akalin; Anil Chandraker; Mary E Russell; Laurence A Turka; Wayne W Hancock; Mohamed H Sayegh
CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo.
Transplantation 1996;62(12):1942-5.
1996: Wayne W Hancock; Mohamed H Sayegh; X G Zheng; R Peach; Peter Linsley; Laurence A Turka
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13967-72.
1996: Steven F Bolling; H Lin; R Q Wei; Laurence A Turka
Preventing allograft rejection with CTLA4IG: effect of donor-specific transfusion route or timing.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1996;15(9):928-35.
1996: A Tang; T A Judge; B J Nickoloff; Laurence A Turka
Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):117-25.
1996: Steven F Bolling; H Lin; Laurence A Turka
The time course of CTLAIg effect on cardiac allograft rejection.
The Journal of surgical research 1996;63(1):320-3.
1996: T A Judge; A Tang; Lisa M. Spain; J Deans-Gratiot; Mohamed H Sayegh; Laurence A Turka
The in vivo mechanism of action of CTLA4Ig.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(6):2294-9.
1996: T A Judge; A Tang; Laurence A Turka
Immunosuppression through blockade of CD28:B7-mediated costimulatory signals.
Immunologic research 1996;15(1):38-49.
1995: Samia J Khoury; Enver Akalin; Anil Chandraker; Laurence A Turka; Peter Linsley; Mohamed H Sayegh; Wayne W Hancock
CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4521-4.
1995: Laurence A Turka; RE Goodman; JL Rutkowski; Anders A F Sima; A Merry; Raj S Mitra; T Wrone-Smith; Galen Toews; Robert M Strieter; Brian J Nickoloff
Interleukin 12: a potential link between nerve cells and the immune response in inflammatory disorders.
Molecular medicine (Cambridge, Mass.) 1995;1(6):690-9.
1995: Brian J Nickoloff; Laurence A Turka; Raj S Mitra; F O Nestle
Direct and indirect control of T-cell activation by keratinocytes.
The Journal of investigative dermatology 1995;105(1 Suppl):25S-29S.
1995: Mohamed H Sayegh; Enver Akalin; Wayne W Hancock; Mary E Russell; Charles B Carpenter; Peter Linsley; Laurence A Turka
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.
The Journal of experimental medicine 1995;181(5):1869-74.
1995: Raj S Mitra; T A Judge; F O Nestle; Laurence A Turka; Brian J Nickoloff
Psoriatic skin-derived dendritic cell function is inhibited by exogenous IL-10. Differential modulation of B7-1 (CD80) and B7-2 (CD86) expression.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2668-77.
1995: M Tewari; F W Wolf; Michael F Seldin; K Sue O'Shea; Xiaodong Huang; Laurence A Turka
Lymphoid expression and regulation of A20, an inhibitor of programmed cell death.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1699-706.
1995: T A Judge; Ming Liu; Paul J Christensen; J J Fak; Laurence A Turka
Cloning the rat homolog of the CD28/CTLA-4-ligand B7-1: structural and functional analysis.
International immunology 1995;7(2):171-8.
1994: H Lin; R Q Wei; David F Gordon; P Linsley; Laurence A Turka; Steven F Bolling
Review of CTLA4Ig use for allograft immunosuppression.
Transplantation proceedings 1994;26(6):3200-1.
1994: J Gratiot-Deans; Laurence A Turka
New biologic immunosuppressive agents in transplantation.
Current opinion in nephrology and hypertension 1994;3(6):596-601.
1994: J Gratiot-Deans; Ramón Merino; Gabriel Nuñez; Laurence A Turka
Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10685-9.
1994: Brian J Nickoloff; Laurence A Turka
Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes.
Immunology today 1994;15(10):464-9.
1994: Steven F Bolling; H Lin; R Q Wei; P Linsley; Laurence A Turka
The effect of combination cyclosporine and CTLA4-Ig therapy on cardiac allograft survival.
The Journal of surgical research 1994;57(1):60-4.
1994: F O Nestle; Laurence A Turka; Brian J Nickoloff
Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines.
The Journal of clinical investigation 1994;94(1):202-9.
1994: RE Goodman; F Nestle; Y M Naidu; J M Green; Craig Thompson; Brian J Nickoloff; Laurence A Turka
Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5189-98.
1994: F O Nestle; Craig Thompson; Yoji Shimizu; Laurence A Turka; Brian J Nickoloff
Costimulation of superantigen-activated T lymphocytes by autologous dendritic cells is dependent on B7.
Cellular immunology 1994;156(1):220-9.
1994: Brian J Nickoloff; F O Nestle; X G Zheng; Laurence A Turka
T lymphocytes in skin lesions of psoriasis and mycosis fungoides express B7-1: a ligand for CD28.
Blood 1994;83(9):2580-6.
1994: J M Green; X G Zheng; Yoji Shimizu; Craig Thompson; Laurence A Turka
T cell receptor stimulation, but not CD28 costimulation, is dependent on LFA-1-mediated events.
European journal of immunology 1994;24(1):265-72.
1993: F O Nestle; X G Zheng; Craig Thompson; Laurence A Turka; Brian J Nickoloff
Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6535-45.
1993: H Lin; Steven F Bolling; P S Linsley; R Q Wei; David F Gordon; Craig Thompson; Laurence A Turka
Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.
The Journal of experimental medicine 1993;178(5):1801-6.
1993: Brian J Nickoloff; Raj S Mitra; J Green; Yoji Shimizu; Craig Thompson; Laurence A Turka
Activated keratinocytes present bacterial-derived superantigens to T lymphocytes: relevance to psoriasis.
Journal of dermatological science 1993;6(2):127-33.
1993: Lawrence Boise; M González-García; C E Postema; L Ding; T Lindsten; Laurence A Turka; X Mao; Gabriel Nuñez; Craig Thompson
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.
Cell 1993;74(4):597-608.
1993: Wayne T McCormack; Ming Liu; C Postema; Craig Thompson; Laurence A Turka
Excision products of TCR V alpha recombination contain in-frame rearrangements: evidence for continued V(D)J recombination in TCR+ thymocytes.
International immunology 1993;5(7):801-4.
1993: J Gratiot-Deans; L Ding; Laurence A Turka; Gabriel Nuñez
bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):83-91.
1993: Beverly S Mitchell; J S Dayton; Laurence A Turka; Craig Thompson
IMP dehydrogenase inhibitors as immunomodulators.
Annals of the New York Academy of Sciences 1993;685():217-24.
1993: J R Strahler; XX Zhu; Nivedita Hora; Y K Wang; Philip C Andrews; N A Roseman; James V Neel; Laurence A Turka; S M Hanash
Maturation stage and proliferation-dependent expression of dUTPase in human T cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):4991-5.
1993: Laurence A Turka; J Gratiot-Deans; D Keim; R Bandukwala; J Green; J Strahler; S M Hanash
Elevated proliferating cell nuclear antigen levels in immature thymocytes. Dissociation from cell cycle progression.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(7):2746-52.
1993: Brian J Nickoloff; Raj S Mitra; K Lee; Laurence A Turka; J Green; Craig Thompson; Yoji Shimizu
Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo.
The American journal of pathology 1993;142(4):1029-40.
1993: Brian J Nickoloff; Raj S Mitra; J Green; X G Zheng; Yoji Shimizu; Craig Thompson; Laurence A Turka
Accessory cell function of keratinocytes for superantigens. Dependence on lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(6):2148-59.
1992: B Y Wu; E W Hanley; Laurence A Turka; Gary Nabel
Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines.
Blood 1992;80(10):2571-6.
1992: Laurence A Turka; Peter Linsley; H Lin; W Brady; Jeffrey M Leiden; R Q Wei; M L Gibson; X G Zheng; S Myrdal; David F Gordon
T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):11102-5.
1992: J M Green; Laurence A Turka; Carl H June; Craig Thompson
CD28 and staphylococcal enterotoxins synergize to induce MHC-independent T-cell proliferation.
Cellular immunology 1992;145(1):11-20.
1992: J Gratiot-Deans; D Keim; J R Strahler; Laurence A Turka; S Hanash
Differential expression of Op18 phosphoprotein during human thymocyte maturation.
The Journal of clinical investigation 1992;90(4):1576-81.
1992: Laurence A Turka; M C Fletcher; Nancy Craighead; Craig Thompson; Carl H June
Defective signal transduction by the CD2 molecule in immature T-cell receptor/CD3- thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8706-10.
1992: J S Dayton; Laurence A Turka; Craig Thompson; Beverly S Mitchell
Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism.
Molecular pharmacology 1992;41(4):671-6.
1992: P Vandenberghe; Gordon J Freeman; Lee M Nadler; M C Fletcher; M Kamoun; Laurence A Turka; J A Ledbetter; Craig Thompson; Carl H June
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.
The Journal of experimental medicine 1992;175(4):951-60.
1992: Laurence A Turka; S B Kanner; G L Schieven; Craig Thompson; J A Ledbetter
CD45 modulates T cell receptor/CD3-induced activation of human thymocytes via regulation of tyrosine phosphorylation.
European journal of immunology 1992;22(2):551-7.
1991: Laurence A Turka; David G Schatz; M A Oettinger; J J Chun; C Gorka; K Lee; Wayne T McCormack; Craig Thompson
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
Science (New York, N.Y.) 1991;253(5021):778-81.
1991: Laurence A Turka; J Dayton; G Sinclair; Craig Thompson; Beverly S Mitchell
Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine.
The Journal of clinical investigation 1991;87(3):940-8.
1991: J S Dayton; Laurence A Turka; Craig Thompson; Beverly S Mitchell
Guanine ribonucleotide depletion inhibits T cell activation.
Advances in experimental medicine and biology 1991;309B():293-6.
1990: Kelvin P Lee; C Taylor; B Petryniak; Laurence A Turka; Carl H June; Craig Thompson
The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):344-52.
1990: Laurence A Turka; J A Ledbetter; K Lee; Carl H June; Craig Thompson
CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1646-53.
1989: SC Guba; G Stella; Laurence A Turka; Carl H June; Craig Thompson; Stephen G Emerson
Regulation of interleukin 3 gene induction in normal human T cells.
The Journal of clinical investigation 1989;84(6):1701-6.
1989: E L Ramos; Laurence A Turka; J E Leggat; I G Wood; E L Milford; Charles B Carpenter
Decrease in phenotypically defined T helper inducer cells (T4+4B4+) and increase in T suppressor effector cells (T8+2H4+) in stable renal allograft recipients.
Transplantation 1989;47(3):465-71.
1989: Laurence A Turka; J E Goguen; Charles B Carpenter; E L Milford
The effect of historical crossmatches and sensitization of renal allograft survival.
Transplantation proceedings 1989;21(1 Pt 1):696-7.
1989: Charles B Carpenter; J E Goguen; J W Bradley; Laurence A Turka; S I Cho; E L Milford
HLA-B, DR matching and cadaver renal allograft survival in New England. New England Organ Bank.
Transplantation proceedings 1989;21(1 Pt 1):663-4.
1989: Laurence A Turka; J E Goguen; J E Gagne; E L Milford
Presensitization and the renal allograft recipient.
Transplantation 1989;47(2):234-40.
1989: Laurence A Turka; K Tanaka; JW Kupiec-Weglinski; E L Milford; Nicholas L Tilney; Charles B Carpenter
In vivo activity of mixed lymphocyte response-generated suppressor cells and ability to prolong cardiac allograft survival in rats.
Transplantation 1989;47(2):388-90.
1989: Laurence A Turka; Charles B Carpenter; Edmond J Yunis; E L Milford
Selective sparing of suppressor cells generated in mixed lymphocyte response by an anti-interleukin-2 receptor antibody.
Transplantation 1989;47(1):182-8.
1987: Laurence A Turka; E L Ramos; J E Leggat; E L Milford; Patricia A Fraser; Charles B Carpenter
Antigen specificity of mixed lymphocyte response-induced suppressor cells.
Human immunology 1987;20(4):293-306.