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Jeremy Turnbull

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Occupations

Glycomics

Phenomena

Protein Binding

Co-author Network

Publications

TOP 3
Jennifer R Higginson; Alessandra Santos-Silva; Sophie M Thompson; Jeremy E Turnbull; Scott E Guimond; Susan C Barnett
Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation.
Tania M Puvirajesinghe; Yassir A Ahmed; David G Fernig; Scott E Guimond; Andrew K Powell; Jeremy E Turnbull
Array-based functional screening of heparin glycans.
Jeremy E Turnbull
Chemistry. Getting the farm out of pharma for heparin production.

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All Publications

2012: Jennifer R Higginson; Alessandra Santos-Silva; Sophie M Thompson; Jeremy E Turnbull; Scott E Guimond; Susan C Barnett
Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(45):15902-12.
2012: Tania M Puvirajesinghe; Yassir A Ahmed; David G Fernig; Scott E Guimond; Andrew K Powell; Jeremy E Turnbull
Array-based functional screening of heparin glycans.
Chemistry & biology 2012;19(5):553-8.
2011: Jeremy E Turnbull
Chemistry. Getting the farm out of pharma for heparin production.
Science (New York, N.Y.) 2011;334(6055):462-3.
2011: Sophie M Thompson; Jeremy E Turnbull; Toin H van Kuppevelt; Ruoyan Xu; Marilyn G Connell; David G Fernig; Paul D Losty; Edwin C Jesudason
Structure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation?
BMC developmental biology 2011;11():38.
2010: Tim Rudd; Katarzyna A Uniewicz; Alessandro Ori; Scott E Guimond; Mark A Skidmore; Davide Gaudesi; Ruoyan Xu; Jeremy E Turnbull; marco Guerrini; Giangiacomo Torri; Giuliano Siligardi; Mark C Wilkinson; David G Fernig; Edwin A Yates
Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships.
Organic & biomolecular chemistry 2010;8(23):5390-7.
2010: Mark A Skidmore; Scott E Guimond; Audrey F Dumax-Vorzet; Edwin A Yates; Jeremy E Turnbull
Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection.
Nature protocols 2010;5(12):1983-92.
2010: Jeremy E Turnbull
Heparan sulfate glycomics: towards systems biology strategies.
Biochemical Society transactions 2010;38(5):1356-60.
2010: Jeremy E Turnbull; Ram Sasisekharan
Glycomics: technologies taming a frontier omics field.
Omics : a journal of integrative biology 2010;14(4):385-7.
2010: Sophie M Thompson; Edwin C Jesudason; Jeremy E Turnbull; David G Fernig
Heparan sulfate in lung morphogenesis: The elephant in the room.
Birth defects research. Part C, Embryo today : reviews 2010;90(1):32-44.
2010: Jeremy E Turnbull; Rebecca L Miller; Yassir Ahmed; Tania M Puvirajesinghe; Scott E Guimond
Glycomics profiling of heparan sulfate structure and activity.
Methods in enzymology 2010;480():65-85.
2009: Sophie M Thompson; David G Fernig; Edwin C Jesudason; Paul D Losty; Els M A van de Westerlo; Toin H van Kuppevelt; Jeremy E Turnbull
Heparan sulfate phage display antibodies identify distinct epitopes with complex binding characteristics: insights into protein binding specificities.
The Journal of biological chemistry 2009;284(51):35621-31.
2009: Sailaja Arungundram; Kanar Al-Mafraji; Jinkeng Asong; Franklin E Leach; I Jonathan Amster; Andre Venot; Jeremy E Turnbull; Gerardus Josephus Boons
Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies.
Journal of the American Chemical Society 2009;131(47):17394-405.
2009: T M Puvirajesinghe; Scott E Guimond; Jeremy E Turnbull; S Guenneau
Chemometric analysis for comparison of heparan sulphate oligosaccharides.
Journal of the Royal Society, Interface / the Royal Society 2009;6(40):997-1004.
2009: Tim Rudd; Mark A Skidmore; Scott E Guimond; Joseph Holman; Jeremy E Turnbull; Robert Lauder; David G Fernig; Edwin A Yates
The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids.
Thrombosis and haemostasis 2009;102(5):874-8.
2009: Scott E Guimond; Tania M Puvirajesinghe; Mark A Skidmore; Ina Kalus; Thomas Dierks; Edwin A Yates; Jeremy E Turnbull
Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling.
The Journal of biological chemistry 2009;284(38):25714-22.
2009: Scott E Guimond; Tim Rudd; Mark A Skidmore; Alessandro Ori; Davide Gaudesi; Cesare Cosentino; marco Guerrini; Ruth Edge; David Collison; Eric McInnes; Giangiacomo Torri; Jeremy E Turnbull; David G Fernig; Edwin A Yates
Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution.
Biochemistry 2009;48(22):4772-9.
2009: Nicola Wells; Melissa A Baxter; Jeremy E Turnbull; Patricia Murray; David Edgar; Kristina L Parry; David A Steele; Robert D Short
The geometric control of E14 and R1 mouse embryonic stem cell pluripotency by plasma polymer surface chemical gradients.
Biomaterials 2009;30(6):1066-70.
2009: Mark Skidmore; Abdel Atrih; Ed Yates; Jeremy E Turnbull
Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations.
Methods in molecular biology (Clifton, N.J.) 2009;534():157-69.
2009: Andrew K Powell; Zheng-Liang Zhi; Jeremy E Turnbull
Saccharide microarrays for high-throughput interrogation of glycan-protein binding interactions.
Methods in molecular biology (Clifton, N.J.) 2009;534():313-29.
2008: Bérangère Tissot; Alessio Ceroni; Andrew K Powell; Howard R Morris; Edwin A Yates; Jeremy E Turnbull; John T Gallagher; Anne Dell; Stuart M Haslam
Software tool for the structural determination of glycosaminoglycans by mass spectrometry.
Analytical chemistry 2008;80(23):9204-12.
2008: Tim Rudd; Mark A Skidmore; Scott E Guimond; marco Guerrini; Cesare Cosentino; R Edge; A Brown; D T Clarke; Giangiacomo Torri; Jeremy E Turnbull; Richard J Nichols; David G Fernig; Edwin A Yates
Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques.
Carbohydrate research 2008;343(12):2184-93.
2008: Zheng-Liang Zhi; Nicolas Laurent; Andrew K Powell; Rositsa Karamanska; Margherita Fais; Josef Voglmeir; Adam Wright; Jonathan M Blackburn; Paul R Crocker; David A Russell; Sabine Flitsch; Robert A Field; Jeremy E Turnbull
A versatile gold surface approach for fabrication and interrogation of glycoarrays.
Chembiochem : a European journal of chemical biology 2008;9(10):1568-75.
2008: Mark A Skidmore; Audrey F Dumax-Vorzet; Scott E Guimond; Tim Rudd; Elizabeth A Edwards; Jeremy E Turnbull; Alister G Craig; Edwin A Yates
Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities.
Journal of medicinal chemistry 2008;51(5):1453-8.
2008: Mark A Skidmore; Scott E Guimond; Tim Rudd; David G Fernig; Jeremy E Turnbull; Edwin A Yates
The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation.
Connective tissue research 2008;49(3):140-4.
2008: Susannah J Patey; E A Edwards; Edwin A Yates; Jeremy E Turnbull
Engineered heparins: novel beta-secretase inhibitors as potential Alzheimer's disease therapeutics.
Neuro-degenerative diseases 2008;5(3-4):197-9.
2007: Bérangère Tissot; Nijole Gasiunas; Andrew K Powell; Yassir Ahmed; Zheng-liang Zhi; Stuart M Haslam; Howard R Morris; Jeremy E Turnbull; John T Gallagher; Anne Dell
Towards GAG glycomics: analysis of highly sulfated heparins by MALDI-TOF mass spectrometry.
Glycobiology 2007;17(9):972-82.
2007: Tim Rudd; Scott E Guimond; Mark A Skidmore; Laurence Duchesne; marco Guerrini; Giangiacomo Torri; Cesare Cosentino; Alan Brown; David T Clarke; Jeremy E Turnbull; David G Fernig; Edwin A Yates
Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives.
Glycobiology 2007;17(9):983-93.
2007: S M Thompson; Marilyn G Connell; David G Fernig; Gerdy B ten Dam; Toin H van Kuppevelt; Jeremy E Turnbull; Edwin C Jesudason; Paul D Losty
Novel 'phage display antibodies identify distinct heparan sulfate domains in developing mammalian lung.
Pediatric surgery international 2007;23(5):411-7.
2006: Sadaf-Ahmahni Hussain; Michael Piper; Noémi Fukuhara; Laure Strochlic; Gian Cho; Jason A Howitt; Yassir Ahmed; Andrew K Powell; Jeremy E Turnbull; Christine E Holt; Erhard Hohenester
A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.
The Journal of biological chemistry 2006;281(51):39693-8.
2006: Mark A Skidmore; Scott E Guimond; A F Dumax-Vorzet; A Atrih; Edwin A Yates; Jeremy E Turnbull
High sensitivity separation and detection of heparan sulfate disaccharides.
Journal of chromatography. A 2006;1135(1):52-6.
2006: Susannah J Patey; Elizabeth A Edwards; Edwin A Yates; Jeremy E Turnbull
Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase, with reduced activity against factor Xa and other proteases.
Journal of medicinal chemistry 2006;49(20):6129-32.
2006: Scott E Guimond; Jeremy E Turnbull; Edwin A Yates
Engineered bio-active polysaccharides from heparin.
Macromolecular bioscience 2006;6(8):681-6.
2006: Zheng-liang Zhi; Andrew K Powell; Jeremy E Turnbull
Fabrication of carbohydrate microarrays on gold surfaces: direct attachment of nonderivatized oligosaccharides to hydrazide-modified self-assembled monolayers.
Analytical chemistry 2006;78(14):4786-93.
2006: W E Leadbeater; A-M Gonzalez; N Logaras; Martin Berry; Jeremy E Turnbull; Ann Logan
Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex.
Journal of neurochemistry 2006;96(4):1189-200.
2005: Susannah J Patey; Edwin A Yates; Jeremy E Turnbull
Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.
Biochemical Society transactions 2005;33(Pt 5):1116-8.
2005: David C West; Chris G Rees; Laurence Duchesne; Susannah J Patey; Carla J Terry; Jeremy E Turnbull; Maryse DELEHEDDE; christian heegaard; Fabrice Allain; Christophe Vanpouille; David Ron; David G Fernig
Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2.
The Journal of biological chemistry 2005;280(14):13457-64.
2005: Tarja Kinnunen; Zebo Huang; Joanne Townsend; Michelle M Gatdula; Jillian R Brown; Jeffrey D Esko; Jeremy E Turnbull
Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1507-12.
2004: Mark A Skidmore; Susannah J Patey; Nguyen T K Thanh; David G Fernig; Jeremy E Turnbull; Edwin A Yates
Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces.
Chemical communications (Cambridge, England) 2004;(23):2700-1.
2004: Andrew K Powell; Edwin A Yates; David G Fernig; Jeremy E Turnbull
Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches.
Glycobiology 2004;14(4):17R-30R.
2004: Edwin A Yates; Scott E Guimond; Jeremy E Turnbull
Highly diverse heparan sulfate analogue libraries: providing access to expanded areas of sequence space for bioactivity screening.
Journal of medicinal chemistry 2004;47(1):277-80.
2003: Zoe Scholefield; Edwin A Yates; Gareth Wayne; Augustin Amour; William McDowell; Jeremy E Turnbull
Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.
The Journal of cell biology 2003;163(1):97-107.
2003: Jamie Andrew Davies; Edwin A Yates; Jeremy E Turnbull
Structural determinants of heparan sulphate modulation of GDNF signalling.
Growth factors (Chur, Switzerland) 2003;21(3-4):109-19.
2002: Miriam Ford-Perriss; Scott E Guimond; Ursula Greferath; Magdalena Kita; Kay Grobe; Hiroko Habuchi; Koji Kimata; Jeffrey D Esko; Mark Murphy; Jeremy E Turnbull
Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.
Glycobiology 2002;12(11):721-7.
2002: Andrew K Powell; David G Fernig; Jeremy E Turnbull
Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate. Implications for dynamic assembly of a ternary signaling complex.
The Journal of biological chemistry 2002;277(32):28554-63.
2002: Richard G Warner; Christoph Hundt; Stefan Weiss; Jeremy E Turnbull
Identification of the heparan sulfate binding sites in the cellular prion protein.
The Journal of biological chemistry 2002;277(21):18421-30.
2002: Atsushi Irie; Edwin A Yates; Jeremy E Turnbull; Christine E Holt
Specific heparan sulfate structures involved in retinal axon targeting.
Development (Cambridge, England) 2002;129(1):61-70.
2001: KJ Drummond; Edwin A Yates; Jeremy E Turnbull
Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label.
Proteomics 2001;1(2):304-10.
2001: Jeremy E Turnbull
Analytical and preparative strong anion-exchange HPLC of heparan sulfate and heparin saccharides.
Methods in molecular biology (Clifton, N.J.) 2001;171():141-7.
2001: Jeremy E Turnbull
Integral glycan sequencing of heparan sulfate and heparin saccharides.
Methods in molecular biology (Clifton, N.J.) 2001;171():129-39.
1999: Scott E Guimond; Jeremy E Turnbull
Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides.
Current biology : CB 1999;9(22):1343-6.
1999: Jeremy E Turnbull; J J Hopwood; John T Gallagher
A strategy for rapid sequencing of heparan sulfate and heparin saccharides.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2698-703.
1998: David A Pye; R R Vives; Jeremy E Turnbull; Paula Hyde; John T Gallagher
Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity.
The Journal of biological chemistry 1998;273(36):22936-42.
1998: YG Brickman; V Nurcombe; MD Ford; John T Gallagher; Perry F Bartlett; Jeremy E Turnbull
Structural comparison of fibroblast growth factor-specific heparan sulfates derived from a growing or differentiating neuroepithelial cell line.
Glycobiology 1998;8(5):463-71.
1998: YG Brickman; MD Ford; John T Gallagher; V Nurcombe; Perry F Bartlett; Jeremy E Turnbull
Structural modification of fibroblast growth factor-binding heparan sulfate at a determinative stage of neural development.
The Journal of biological chemistry 1998;273(8):4350-9.
1998: Gordon C Jayson; Malcolm Lyon; C Paraskeva; Jeremy E Turnbull; Jon A Deakin; John T Gallagher
Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro.
The Journal of biological chemistry 1998;273(1):51-7.