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Anthony Turner
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88
Hooper, Nigel
28
Barnes, Kay
17
Parkin, Edward
9
Karran, EH
8
Murphy, Liam
8
Nalivaeva, Natalia
7
Hussain, Ishrut
7
Guy, Jodie
6
Lambert, Daniel
6
Parvathy, S
5
Isaac, Elwyn
5
Usmani, Badar
4
Takehara, Tadamichi
4
Warner, Fiona
4
Williams, TA
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All Publications
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2009: Nalivaeva Natalia N; Belyaev Nikolai D; Turner Anthony J
Sodium valproate: an old drug with new roles.
Trends in pharmacological sciences 2009;30(10):509-14.
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2009: Hunt Clare E; Turner Anthony J
Cell biology, regulation and inhibition of beta-secretase (BACE-1).
The FEBS journal 2009;276(7):1845-59.
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2009: Bland Nicholas D; Robinson Philip; Thomas Josie E; Shirras Alan D; Turner Anthony J; Isaac R Elwyn
Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2.
Peptides 2009;30(3):571-4.
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2008: Cilia La Corte Amy L; Carter Angela M; Turner Anthony J; Grant Peter J; Hooper Nigel M
The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2008;9(4):221-5.
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2008: Rushworth Christopher A; Guy Jodie L; Turner Anthony J
Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis.
The FEBS journal 2008;275(23):6033-42.
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2008: Lambert L A; Whyteside A R; Turner A J; Usmani B A
Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion.
British journal of cancer 2008;99(7):1114-20.
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2008: Whyteside Alison R; Turner Anthony J
Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences.
FEBS letters 2008;582(16):2382-6.
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2008: Guy Jodie L; Lambert Daniel W; Turner Anthony J; Porter Karen E
Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts.
Experimental physiology 2008;93(5):579-88.
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2008: Nalivaeva Natalia N; Fisk Lilia R; Belyaev Nikolai D; Turner Anthony J
Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease.
Current Alzheimer research 2008;5(2):212-24.
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2008: Hooper Nigel M; Turner Anthony J
A new take on prions: preventing Alzheimer's disease.
Trends in biochemical sciences 2008;33(4):151-5.
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2008: Lambert Daniel W; Hooper Nigel M; Turner Anthony J
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.
Biochemical pharmacology 2008;75(4):781-6.
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2008: Lambert Daniel W; Clarke Nicola E; Hooper Nigel M; Turner Anthony J
Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain.
FEBS letters 2008;582(2):385-90.
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2008: Bland Nicholas D; Pinney John W; Thomas Josie E; Turner Anthony J; Isaac R Elwyn
Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships.
BMC evolutionary biology 2008;8():16.
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2007: Fisk Lilia; Nalivaeva Natalia N; Boyle John P; Peers Christopher S; Turner Anthony J
Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes.
Neurochemical research 2007;32(10):1741-8.
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2007: Parkin Edward T; Watt Nicole T; Hussain Ishrut; Eckman Elizabeth A; Eckman Christopher B; Manson Jean C; Baybutt Herbert N; Turner Anthony J; Hooper Nigel M
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):11062-7.
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2007: Bland Nicholas D; Thomas Josie E; Audsley Neil; Shirras Alan D; Turner Anthony J; Isaac R Elwyn
Expression of NEP2, a soluble neprilysin-like endopeptidase, during embryogenesis in Drosophila melanogaster.
Peptides 2007;28(1):127-35.
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2007: Turner A J; Nalivaeva N N
New insights into the roles of metalloproteinases in neurodegeneration and neuroprotection.
International review of neurobiology 2007;82():113-35.
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2007: Rella Monika; Elliot Joann L; Revett Timothy J; Lanfear Jerry; Phelan Anne; Jackson Richard M; Turner Anthony J; Hooper Nigel M
Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE.
BMC genomics 2007;8():194.
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2006: Dubrovskaya N M; Nalivaeva N N; Turner A J; Zhuravin I A
Effects of an inhibitor of alpha-secretase, which metabolizes the amyloid peptide precursor, on memory formation in rats.
Neuroscience and behavioral physiology 2006;36(9):911-3.
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2006: Rice Gillian I; Jones Amy L; Grant Peter J; Carter Angela M; Turner Anthony J; Hooper Nigel M
Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study.
Hypertension 2006;48(5):914-20.
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2006: Dawson Louise A; Maitland Norman J; Berry Paul; Turner Anthony J; Usmani Badar A
Expression and localization of endothelin-converting enzyme-1 in human prostate cancer.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):1106-10.
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2006: Fisk Lilia; Nalivaeva Natalia N; Turner Anthony J
Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):1048-53.
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2006: Jackson Carolyn D; Barnes Kay; Homer-Vanniasinkam Shervanthi; Turner Anthony J
Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):794-801.
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2006: Hunter Alison R; Turner Anthony J
Expression and localization of endothelin-converting enzyme-1 isoforms in human endothelial cells.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):718-22.
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2006: Awano Shuji; Dawson Louise A; Hunter Alison R; Turner Anthony J; Usmani Badar A
Endothelin system in oral squamous carcinoma cells: specific siRNA targeting of ECE-1 blocks cell proliferation.
International journal of cancer. Journal international du cancer 2006;118(7):1645-52.
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2006: Rella Monika; Rushworth Christopher A; Guy Jodie L; Turner Anthony J; Langer Thierry; Jackson Richard M
Structure-based pharmacophore design and virtual screening for novel angiotensin converting enzyme 2 inhibitors.
Journal of chemical information and modeling 2006;46(2):708-16.
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2006: Cordy Joanna M; Hooper Nigel M; Turner Anthony J
The involvement of lipid rafts in Alzheimer's disease.
Molecular membrane biology 2006;23(1):111-22.
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2006: Turner A J; Nalivaeva N N
Proteinase dysbalance in pathology: the neprilysin (NEP) and angiotensin-converting enzyme (ACE) families.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(4):40-8.
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2005: Dubrovskaia N M; Nalivaeva N N; Turner A J; Zhuravin I A
[Effect of an inhibitor of alpha-secretase metabolizing amyloid precursor protein on memory in rats]
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 2005;55(6):725-8.
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2005: Warner Fiona J; Lew Rebecca A; Smith A Ian; Lambert Daniel W; Hooper Nigel M; Turner Anthony J
Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells.
The Journal of biological chemistry 2005;280(47):39353-62.
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2005: Guy J L; Lambert D W; Warner F J; Hooper N M; Turner A J
Membrane-associated zinc peptidase families: comparing ACE and ACE2.
Biochimica et biophysica acta 2005;1751(1):2-8.
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2005: Lambert Daniel W; Yarski Mike; Warner Fiona J; Thornhill Paul; Parkin Edward T; Smith A Ian; Hooper Nigel M; Turner Anthony J
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).
The Journal of biological chemistry 2005;280(34):30113-9.
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2005: Guy Jodie L; Jackson Richard M; Jensen Hanne A; Hooper Nigel M; Turner Anthony J
Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis.
The FEBS journal 2005;272(14):3512-20.
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2005: Thomas Josie E; Rylett Caroline M; Carhan Ahmet; Bland Nicholas D; Bingham Richard J; Shirras Alan D; Turner Anthony J; Isaac R Elwyn
Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function.
The Biochemical journal 2005;386(Pt 2):357-66.
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2004: Nalivaevaa Natalia N; Fisk Lilia; Kochkina Ekaterina G; Plesneva Svetlana A; Zhuravin Igor A; Babusikova Eva; Dobrota Dusan; Turner Anthony J
Effect of hypoxia/ischemia and hypoxic preconditioning/reperfusion on expression of some amyloid-degrading enzymes.
Annals of the New York Academy of Sciences 2004;1035():21-33.
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2004: Turner Anthony J; Fisk Lilia; Nalivaeva Natalia N
Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration.
Annals of the New York Academy of Sciences 2004;1035():1-20.
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2004: Howell Gareth J; Herbert Shane P; Smith Jennifer M; Mittar Shweta; Ewan Lorna C; Mohammed Mudassir; Hunter Alison R; Simpson Nigel; Turner Anthony J; Zachary Ian; Walker John H; Ponnambalam Sreenivasan
Endothelial cell confluence regulates Weibel-Palade body formation.
Molecular membrane biology 2004;21(6):413-21.
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2004: Warner F J; Smith A I; Hooper N M; Turner A J
Angiotensin-converting enzyme-2: a molecular and cellular perspective.
Cellular and molecular life sciences : CMLS 2004;61(21):2704-13.
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2004: Smith A I; Turner A J
What's new in the renin-angiotensin system?
Cellular and molecular life sciences : CMLS 2004;61(21):2675-6.
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2004: Parkin Edward T; Turner Anthony J; Hooper Nigel M
Secretase-mediated cell surface shedding of the angiotensin-converting enzyme.
Protein and peptide letters 2004;11(5):423-32.
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2004: Rice Gillian I; Thomas Daniel A; Grant Peter J; Turner Anthony J; Hooper Nigel M
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism.
The Biochemical journal 2004;383(Pt 1):45-51.
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2004: Allinson Tobias M J; Parkin Edward T; Condon Thomas P; Schwager Sylva L U; Sturrock Edward D; Turner Anthony J; Hooper Nigel M
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.
European journal of biochemistry / FEBS 2004;271(12):2539-47.
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2004: Turner Anthony J; Hiscox Julian A; Hooper Nigel M
ACE2: from vasopeptidase to SARS virus receptor.
Trends in pharmacological sciences 2004;25(6):291-4.
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2004: Dawson L A; Maitland N J; Turner A J; Usmani B A
Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression.
British journal of cancer 2004;90(8):1577-82.
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2004: Keynan Shoshana; Khamaisi Mogher; Dahan Rachel; Barnes Kay; Jackson Carolyn D; Turner Anthony J; Raz Itamar
Increased expression of endothelin-converting enzyme-1c isoform in response to high glucose levels in endothelial cells.
Journal of vascular research 2004;41(2):131-40.
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2004: Parkin Edward T; Watt Nicole T; Turner Anthony J; Hooper Nigel M
Dual mechanisms for shedding of the cellular prion protein.
The Journal of biological chemistry 2004;279(12):11170-8.
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2003: Guy Jodie L; Jackson Richard M; Acharya K Ravi; Sturrock Edward D; Hooper Nigel M; Turner Anthony J
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence.
Biochemistry 2003;42(45):13185-92.
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2003: Allinson Tobias M J; Parkin Edward T; Turner Anthony J; Hooper Nigel M
ADAMs family members as amyloid precursor protein alpha-secretases.
Journal of neuroscience research 2003;74(3):342-52.
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2003: Cordy Joanna M; Hussain Ishrut; Dingwall Colin; Hooper Nigel M; Turner Anthony J
Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11735-40.
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2003: Parkin Edward T; Tan Fulong; Skidgel Randal A; Turner Anthony J; Hooper Nigel M
The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.
Journal of cell science 2003;116(Pt 15):3079-87.
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2003: Turner A J
Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries.
Biochemical Society transactions 2003;31(Pt 3):723-7.
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2002: Ansai Toshihiro; Yamamoto Eri; Awano Shuji; Yu Weixian; Turner Anthony J; Takehara Tadamichi
Effects of periodontopathic bacteria on the expression of endothelin-1 in gingival epithelial cells in adult periodontitis.
Clinical science (London, England : 1979) 2002;103 Suppl 48():327S-331S.
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2002: Usmani Badar A; Harden Ben; Maitland Norman J; Turner Anthony J
Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines.
Clinical science (London, England : 1979) 2002;103 Suppl 48():314S-317S.
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2002: Carson Julie A; Ansai Toshihiro; Awano Shuji; Yu Weixian; Takehara Tadamichi; Turner Anthony J
Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1.
Clinical science (London, England : 1979) 2002;103 Suppl 48():90S-93S.
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2002: Canet-Aviles Rosa-Maria; Anderton Mark; Hooper Nigel M; Turner Anthony J; Vaughan Peter F T
Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C.
Brain research. Molecular brain research 2002;102(1-2):62-72.
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2002: Hooper N M; Turner A J
The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease.
Current medicinal chemistry 2002;9(11):1107-19.
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2002: Carson Julie A; Turner Anthony J
Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?
Journal of neurochemistry 2002;81(1):1-8.
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2002: Turner Anthony J; Tipnis Sarah R; Guy Jodie L; Rice Gillian; Hooper Nigel M
ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors.
Canadian journal of physiology and pharmacology 2002;80(4):346-53.
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2002: Parkin Edward T; Trew Alison; Christie Gary; Faller Andrew; Mayer Ruth; Turner Anthony J; Hooper Nigel M
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha.
Biochemistry 2002;41(15):4972-81.
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2002: Turner Anthony J; Hooper Nigel M
The angiotensin-converting enzyme gene family: genomics and pharmacology.
Trends in pharmacological sciences 2002;23(4):177-83.
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2002: Arimoto Takafumi; Ansai Toshihiro; Yu Weixian; Turner Anthony J; Takehara Tadamichi
Kinetic analysis of PPi-dependent phosphofructokinase from Porphyromonas gingivalis.
FEMS microbiology letters 2002;207(1):35-8.
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2002: Jackson Carolyn D; Turner Anthony J
Detection and assessment of endothelin-converting enzyme activity.
Methods in molecular biology (Clifton, N.J.) 2002;206():107-24.
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2001: Parkin E T; Turner A J; Hooper N M
Differential effects of glycosphingolipids on the detergent-insolubility of the glycosylphosphatidylinositol-anchored membrane dipeptidase.
The Biochemical journal 2001;358(Pt 1):209-16.
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2001: Nalivaeva N N; Turner A J
Post-translational modifications of proteins: acetylcholinesterase as a model system.
Proteomics 2001;1(6):735-47.
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2001: Alfalah M; Parkin E T; Jacob R; Sturrock E D; Mentele R; Turner A J; Hooper N M; Naim H Y
A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase.
The Journal of biological chemistry 2001;276(24):21105-9.
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2001: Turner A J; Isaac R E; Coates D
The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function.
BioEssays : news and reviews in molecular, cellular and developmental biology 2001;23(3):261-9.
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2000: Cottrell G S; Hyde R J; Lim J; Parsons M R; Hooper N M; Turner A J
Identification of critical residues in the active site of porcine membrane-bound aminopeptidase P.
Biochemistry 2000;39(49):15129-35.
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2000: Cottrell G S; Hooper N M; Turner A J
Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme.
Biochemistry 2000;39(49):15121-8.
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2000: Brown C D; Barnes K; Turner A J
Functional significance of the isoforms of endothelin-converting enzyme-1.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S26-7.
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2000: Tipnis S R; Hooper N M; Hyde R; Karran E; Christie G; Turner A J
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.
The Journal of biological chemistry 2000;275(43):33238-43.
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2000: Hooper N M; Turner A J
Protein processing mechanisms: from angiotensin-converting enzyme to Alzheimer's disease.
Biochemical Society transactions 2000;28(4):441-6.
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2000: Hooper N M; Trew A J; Parkin E T; Turner A J
The role of proteolysis in Alzheimer's disease.
Advances in experimental medicine and biology 2000;477():379-90.
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2000: Turner A J; Brown C D; Carson J A; Barnes K
The neprilysin family in health and disease.
Advances in experimental medicine and biology 2000;477():229-40.
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1999: Parkin E T; Turner A J; Hooper N M
Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein.
The Biochemical journal 1999;344 Pt 1():23-30.
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1999: Awano S; Ansai T; Mochizuki H; Yu W; Tanzawa K; Turner A J; Takehara T
Sequencing, expression and biochemical characterization of the Porphyromonas gingivalis pepO gene encoding a protein homologous to human endothelin-converting enzyme.
FEBS letters 1999;460(1):139-44.
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1999: Parvathy S; Hussain I; Karran E H; Turner A J; Hooper N M
Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.
Biochemistry 1999;38(30):9728-34.
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1999: Barnes K; Turner A J
Endothelin converting enzyme is located on alpha-actin filaments in smooth muscle cells.
Cardiovascular research 1999;42(3):814-22.
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1999: Parkin E T; Hussain I; Karran E H; Turner A J; Hooper N M
Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins.
Journal of neurochemistry 1999;72(4):1534-43.
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1999: Turner A J; Hooper N M
Role for ADAM-family proteinases as membrane protein secretases.
Biochemical Society transactions 1999;27(2):255-9.
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1999: Hooper N M; Parvathy S; Karran E H; Turner A J
Angiotensin-converting enzyme and the amyloid precursor protein secretases.
Biochemical Society transactions 1999;27(2):229-34.
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1998: Sansom C E; Hoang M V; Turner A J
Molecular modelling and site-directed mutagenesis of the active site of endothelin-converting enzyme.
Protein engineering 1998;11(12):1235-41.
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1998: Turner A J; Barnes K; Schweizer A; Valdenaire O
Isoforms of endothelin-converting enzyme: why and where?
Trends in pharmacological sciences 1998;19(12):483-6.
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1998: Cottrell G S; Hyde R J; Hooper N M; Turner A J
The cloning and functional expression of human pancreatic aminopeptidase P.
Biochemical Society transactions 1998;26(3):S248.
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1998: Houldsworth S L; Trew A J; Hooper N M; Turner A J
Molecular characterisation of the Alzheimer's amyloid precursor protein secretases.
Biochemical Society transactions 1998;26(3):S245.
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1998: Parvathy S; Hussain I; Karran E H; Turner A J; Hooper N M
The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by hydroxamic acid-based inhibitors.
Biochemical Society transactions 1998;26(3):S242.
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1998: Parkin E T; Turner A J; Hooper N M
Detergent solubility and processing of the familial Alzheimer's disease-related presenilin proteins.
Biochemical Society transactions 1998;26(3):S241.
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1998: Parvathy S; Karran E H; Turner A J; Hooper N M
The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase.
FEBS letters 1998;431(1):63-5.
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1998: Brown C D; Barnes K; Turner A J
Anti-peptide antibodies specific to rat endothelin-converting enzyme-1 isoforms reveal isoform localisation and expression.
FEBS letters 1998;424(3):183-7.
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1998: Parvathy S; Hussain I; Karran E H; Turner A J; Hooper N M
Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase.
Biochemistry 1998;37(6):1680-5.
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1998: Barnes K; Brown C; Turner A J
Endothelin-converting enzyme: ultrastructural localization and its recycling from the cell surface.
Hypertension 1998;31(1):3-9.
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1997: Hoang M V; Sansom C E; Turner A J
Mutagenesis of Glu403 to Cys in rabbit neutral endopeptidase-24.11 (neprilysin) creates a disulphide-linked homodimer: analogy with endothelin-converting enzyme.
The Biochemical journal 1997;327 ( Pt 3)():925-9.
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1997: Parkin E T; Hussain I; Turner A J; Hooper N M
The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains.
Journal of neurochemistry 1997;69(5):2179-88.
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1997: Parvathy S; Oppong S Y; Karran E H; Buckle D R; Turner A J; Hooper N M
Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer.
The Biochemical journal 1997;327 ( Pt 1)():37-43.
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1997: Hoang M V; Turner A J
Novel activity of endothelin-converting enzyme: hydrolysis of bradykinin.
The Biochemical journal 1997;327 ( Pt 1)():23-6.
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1997: Keynan S; Asipu A; Hooper N M; Turner A J; Blair G E
Stable and temperature-sensitive transformation of baby rat kidney cells by SV40 suppresses expression of membrane dipeptidase.
Oncogene 1997;15(10):1241-5.
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1997: Keynan S; Hooper N M; Turner A J
Identification by site-directed mutagenesis of three essential histidine residues in membrane dipeptidase, a novel mammalian zinc peptidase.
The Biochemical journal 1997;326 ( Pt 1)():47-51.
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1997: Barnes K; Turner A J
The endothelin system and endothelin-converting enzyme in the brain: molecular and cellular studies.
Neurochemical research 1997;22(8):1033-40.
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1997: Turner A J; Tanzawa K
Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(5):355-64.
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1997: Barnes K; Walkden B J; Wilkinson T C; Turner A J
Expression of endothelin-converting enzyme in both neuroblastoma and glial cell lines and its localization in rat hippocampus.
Journal of neurochemistry 1997;68(2):570-7.
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1997: Hooper N M; Karran E H; Turner A J
Membrane protein secretases.
The Biochemical journal 1997;321 ( Pt 2)():265-79.
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1997: Turner A J; Hyde R J; Lim J; Hooper N M
Structural studies of aminopeptidase P. A novel cellular peptidase.
Advances in experimental medicine and biology 1997;421():7-16.
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1996: Parkin E T; Turner A J; Hooper N M
Isolation and characterization of two distinct low-density, Triton-insoluble, complexes from porcine lung membranes.
The Biochemical journal 1996;319 ( Pt 3)():887-96.
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1996: Hyde R J; Hooper N M; Turner A J
Molecular cloning and expression in COS-1 cells of pig kidney aminopeptidase P.
The Biochemical journal 1996;319 ( Pt 1)():197-201.
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1996: Medeiros M dos S; Turner A J
Metabolism and functions of neuropeptide Y.
Neurochemical research 1996;21(9):1125-32.
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1996: Keynan S; Habgood N T; Hooper N M; Turner A J
Site-directed mutagenesis of conserved cysteine residues in porcine membrane dipeptidase. Cys 361 alone is involved in disulfide-linked dimerization.
Biochemistry 1996;35(38):12511-7.
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1996: Hoang V M; Sansom C E; Turner A J
Mutagenesis and modeling of endothelin converting enzyme.
Biochemical Society transactions 1996;24(3):471S.
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1996: Hyde R J; Hooper N M; Turner A J
Cloning and functional expression of pig kidney aminopeptidase P.
Biochemical Society transactions 1996;24(3):470S.
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1996: Parkin E T; Turner A J; Hooper N M
A role for calcium and annexins in the formation of caveolae.
Biochemical Society transactions 1996;24(3):444S.
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1996: Lloyd G S; Hryszko J; Hooper N M; Turner A J
Inhibition and metal ion activation of pig kidney aminopeptidase P. Dependence on nature of substrate.
Biochemical pharmacology 1996;52(2):229-36.
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1996: Barnes K; Shimada K; Takahashi M; Tanzawa K; Turner A J
Metallopeptidase inhibitors induce an up-regulation of endothelin-converting enzyme levels and its redistribution from the plasma membrane to an intracellular compartment.
Journal of cell science 1996;109 ( Pt 5)():919-28.
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1996: Lim J; Turner A J
Chemical modification of porcine kidney aminopeptidase P indicates the involvement of two critical histidine residues.
FEBS letters 1996;381(3):188-90.
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1996: Turner A J; Murphy L J
Molecular pharmacology of endothelin converting enzymes.
Biochemical pharmacology 1996;51(2):91-102.
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1996: Turner A J; Murphy L J; Medeiros M S; Barnes K
Endopeptidase-24.11 (neprilysin) and relatives: twenty years on.
Advances in experimental medicine and biology 1996;389():141-8.
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1995: Hooper N M; Oppong S Y; Turner A J
Identification of the site of cleavage in angiotensin converting enzyme by its secretase.
Biochemical Society transactions 1995;23(4):552S.
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1995: Connolly C; Oppong S Y; Turner A J; Hooper N M
Purification and characterization of the angiotensin converting enzyme secretase.
Biochemical Society transactions 1995;23(4):551S.
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1995: Lim J; Turner A J
Chemical modification of aminopeptidase P: identification of a critical histidyl residue.
Biochemical Society transactions 1995;23(4):549S.
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1995: Takahashi M; Fukuda K; Shimada K; Barnes K; Turner A J; Ikeda M; Koike H; Yamamoto Y; Tanzawa K
Localization of rat endothelin-converting enzyme to vascular endothelial cells and some secretory cells.
The Biochemical journal 1995;311 ( Pt 2)():657-65.
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1995: Brewis I A; Ferguson M A; Mehlert A; Turner A J; Hooper N M
Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase. Comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures.
The Journal of biological chemistry 1995;270(39):22946-56.
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1995: Galasko G T; Bao Y; Broomfield S J; Hooper N M; Turner A J; Larner J
Circulating factors and insulin resistance. I. A novel myoinositol 1,2-cyclic phosphate phosphoglycan insulin antagonist from human plasma is elevated in noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1995;80(8):2419-29.
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1995: Keynan S; Hooper N M; Felici A; Amicosante G; Turner A J
The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.
Antimicrobial agents and chemotherapy 1995;39(7):1629-31.
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1995: Murray H; McClaren H; Turner A J; Kenny A J
Immunocytochemical studies of an antigen in a human T-cell lymphoma line (Jurkat) recognized by certain monoclonal antibodies to CD-13 (aminopeptidase-N).
Leukemia & lymphoma 1995;17(5-6):501-8.
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1995: Barnes K; Doherty S; Turner A J
Endopeptidase-24.11 is the integral membrane peptidase initiating degradation of somatostatin in the hippocampus.
Journal of neurochemistry 1995;64(4):1826-32.
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1995: Lloyd G S; Turner A J
Aminopeptidase P: cation activation and inhibitor sensitivity are substrate-dependent.
Biochemical Society transactions 1995;23(1):60S.
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1995: Sansom C E; Hoang V M; Turner A J
Molecular modeling of the active site of endothelin-converting enzyme.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S75-7.
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1995: Walkden B J; Turner A J
Expression of ECE and related membrane peptidases in the EA.hy926 cell line.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S59-60.
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1995: Barnes K; Murphy L J; Takahashi M; Tanzawa K; Turner A J
Localization and biochemical characterization of endothelin-converting enzyme.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S37-9.
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1995: Medeiros M D; Turner A J
Metabolic stability of some tachykinin analogues to cell-surface peptidases: roles for endopeptidase-24.11 and aminopeptidase N.
Peptides 1995;16(3):441-7.
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1994: Greenhough K J; Walkden B J; Murphy L J; McLaren H E; Barnes K; Turner A J
Membrane peptidase activity of a human endothelial cell line (EA.hy 926).
Biochemical Society transactions 1994;22(4):454S.
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1994: Barnes K; Murphy L J; Turner A J
Immunoseparation of membrane peptidases from pig lung membranes using magnetic beads.
Biochemical Society transactions 1994;22(4):451S.
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1994: Habgood N; Eastham H; Turner A J
Molecular cloning of endopeptidase-24.15 from pig brain.
Biochemical Society transactions 1994;22(4):415S.
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1994: Brewis I A; Turner A J; Hooper N M
Activation of the glycosyl-phosphatidylinositol-anchored membrane dipeptidase upon release from pig kidney membranes by phospholipase C.
The Biochemical journal 1994;303 ( Pt 2)():633-8.
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1994: Murphy L J; Corder R; Mallet A I; Turner A J
Generation by the phosphoramidon-sensitive peptidases, endopeptidase-24.11 and thermolysin, of endothelin-1 and c-terminal fragment from big endothelin-1.
British journal of pharmacology 1994;113(1):137-42.
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1994: Keynan S; Hooper N M; Turner A J
Directed mutagenesis of pig renal membrane dipeptidase. His219 is critical but the DHXXH motif is not essential for zinc binding or catalytic activity.
FEBS letters 1994;349(1):50-4.
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1994: Medeiros M D; Turner A J
Processing and metabolism of peptide-YY: pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24.11.
Endocrinology 1994;134(5):2088-94.
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1994: Medeiros M dos S; Turner A J
Comparison of cholecystokinin metabolism by membrane preparations from the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y.
Neurochemistry international 1994;24(4):369-77.
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1994: Barnes K; Kenny A J; Turner A J
Localization of aminopeptidase N and dipeptidyl peptidase IV in pig striatum and in neuronal and glial cell cultures.
The European journal of neuroscience 1994;6(4):531-7.
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1994: Crilley C T; Turner A J
Effect of chemical modification of arginyl and histidyl residues on [3H]MK-801 binding to brain synaptic membranes.
Biochemical pharmacology 1994;47(6):961-7.
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1994: Murray H; Turner A J; Kenny A J
The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13).
The Biochemical journal 1994;298 ( Pt 2)():353-60.
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1994: Turner A J; Barnes K
Neuropeptidases: candidate enzymes and techniques for study.
Biochemical Society transactions 1994;22(1):122-7.
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1994: Turner A J
Structural and immunological studies of GPI-anchored brush border hydrolases.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):389-94.
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1994: Turner A J
PIG-tailed membrane proteins.
Essays in biochemistry 1994;28():113-27.
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1994: Medeiros M S; Turner A J
Post-secretory processing of regulatory peptides: the pancreatic polypeptide family as a model example.
Biochimie 1994;76(3-4):283-7.
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1993: Turner A J
Endothelin-converting enzymes and other families of metallo-endopeptidases.
Biochemical Society transactions 1993;21 ( Pt 3)(3):697-701.
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1993: Crilley C T; Turner A J
Chemical modification of N-methyl-D-aspartate receptors from pig brain.
Biochemical Society transactions 1993;21 ( Pt 3)(3):271S.
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1993: Oppong S Y; Turner A J; Hooper N M
Characterization of the soluble and membrane-bound forms of porcine angiotensin converting enzyme.
Biochemical Society transactions 1993;21 ( Pt 3)(3):251S.
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1993: Medeiros M dos S; Turner A J
Hydrolysis of cholecystokinin by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y.
Biochemical Society transactions 1993;21 ( Pt 3)(3):247S.
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1993: Lloyd G S; Habgood N T; Hooper N M; Turner A J
Aminopeptidase P: immunoaffinity purification and molecular characterisation.
Biochemical Society transactions 1993;21 ( Pt 3)(3):236S.
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1993: Brewis I A; Howell S; Hooper N M; Kenny A J; Turner A J
Membrane peptidase expression by confluent cultures of Caco-2 cells.
Biochemical Society transactions 1993;21 ( Pt 3)(3):252S.
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1993: Medeiros M dos S; Turner A J
Processing and metabolism of peptide YY.
Biochemical Society transactions 1993;21 ( Pt 3)(3):248S.
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1993: Barnes K; Turner A J; Kenny A J
Co-localisation of substance P and endopeptidase-24.11 in pig substantia nigra: an ultrastructural study.
Biochemical Society transactions 1993;21 ( Pt 3)(3):246S.
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1993: Barnes K; Turner A J; Kenny A J
An immunoelectron microscopic study of pig substantia nigra shows co-localization of endopeptidase-24.11 with substance P.
Neuroscience 1993;53(4):1073-82.
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1993: Brewis I A; Ferguson M A; Turner A J; Hooper N M
Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases.
Biochemical Society transactions 1993;21(1):46S.
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1993: Brewis I A; Hooper N M; Turner A J
Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase.
Biochemical Society transactions 1993;21(1):44S.
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1993: Murphy L J; Turner A J
Endothelin converting enzyme of porcine lung.
Biochemical Society transactions 1993;21(1):27S.
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1993: Howell S; Caswell A M; Kenny A J; Turner A J
Membrane peptidases on human osteoblast-like cells in culture: hydrolysis of calcitonin and hormonal regulation of endopeptidase-24.11.
The Biochemical journal 1993;290 ( Pt 1)():159-64.
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1993: Howell S; Brewis I A; Hooper N M; Kenny A J; Turner A J
Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells.
FEBS letters 1993;317(1-2):109-12.
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1993: Murphy L J; Greenhough K J; Turner A J
Processing and metabolism of endothelin peptides by porcine lung membranes.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S94-7.
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1992: Williams T A; Barnes K; Kenny A J; Turner A J; Hooper N M
A comparison of the zinc contents and substrate specificities of the endothelial and testicular forms of porcine angiotensin converting enzyme and the preparation of isoenzyme-specific antisera.
The Biochemical journal 1992;288 ( Pt 3)():875-81.
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1992: Howell S; Caswell A M; Kenny A J; Turner A J
The regulation of endopeptidase-24.11 expression on human osteoblast-like cells in culture.
Biochemical Society transactions 1992;20(3):282S.
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1992: Williams T A; Hooper N M; Barnes K; Kenny A J; Turner A J
Immunological studies on the endothelial and testicular forms of angiotensin converting enzyme.
Biochemical Society transactions 1992;20(3):281S.
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1992: Howell S; Kenny A J; Turner A J
A survey of membrane peptidases in two human colonic cell lines, Caco-2 and HT-29.
The Biochemical journal 1992;284 ( Pt 2)():595-601.
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1992: Barnes K; Turner A J; Kenny A J
Membrane localization of endopeptidase-24.11 and peptidyl dipeptidase A (angiotensin converting enzyme) in the pig brain: a study using subcellular fractionation and electron microscopic immunocytochemistry.
Journal of neurochemistry 1992;58(6):2088-96.
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1992: Hooper N M; Hryszko J; Oppong S Y; Turner A J
Inhibition by converting enzyme inhibitors of pig kidney aminopeptidase P.
Hypertension 1992;19(3):281-5.
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1991: Turner A J; dos Santos Medeiros M; Hooper N M
The molecular biology of GPI-anchored border hydrolases.
Cell biology international reports 1991;15(11):1083-99.
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1991: Howell S; Murray H; Scott C S; Turner A J; Kenny A J
A highly sensitive E.L.I.S.A. for endopeptidase-24.11, the common acute-lymphoblastic-leukaemia antigen (CALLA, CD-10), applicable to material of porcine and human origin.
The Biochemical journal 1991;278 ( Pt 2)():417-21.
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1991: Medeiros M dos S; Balmforth A J; Vaughan P F; Turner A J
Hydrolysis of atrial and brain natriuretic peptides by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y.
Neuroendocrinology 1991;54(3):295-302.
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1991: Williams T A; Hooper N M; Turner A J
Characterization of neuronal and endothelial forms of angiotensin converting enzyme in pig brain.
Journal of neurochemistry 1991;57(1):193-9.
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1991: Millican P E; Kenny A J; Turner A J
Purification and properties of a neurotensin-degrading endopeptidase from pig brain.
The Biochemical journal 1991;276 ( Pt 3)():583-91.
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1991: Medeiros M dos S; Turner A J; Ljungqvist A; Folkers K
Metabolic stability of the LHRH antagonist antide to cell-surface peptidases.
Biochemical and biophysical research communications 1991;176(1):25-30.
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1991: Howell S; Murray H; Kenny A J; Turner A J
A sensitive enzyme-linked immunosorbent assay for endopeptidase-24.11.
Biochemical Society transactions 1991;19(1):1S.
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1991: Greenhough K J; Turner A J
Aminoacylase I is not a glycolipid-anchored ectoenzyme in pig kidney.
Biochimica et biophysica acta 1991;1076(3):364-8.
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1991: Turner A J; Widdows K B; Kirkness E F
Probing the GABAA receptor with antibodies.
Biochemical Society transactions 1991;19(1):124-8.
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1991: Hooper N M; Broomfield S J; Turner A J
Characterization of antibodies to the glycosyl-phosphatidylinositol membrane anchors of mammalian proteins.
The Biochemical journal 1991;273(Pt 2)():301-6.
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1991: Barnes K; Bourne A; Cook P A; Turner A J; Kenny A J
Membrane peptidases in the peripheral nervous system of the pig: their localization by immunohistochemistry at light and electron microscopic levels.
Neuroscience 1991;44(1):245-61.
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1990: Medeiros M dos S; Balmforth A J; Vaughan P F; Kenny A J; Turner A J
Hydrolysis of natriuretic peptides by the human astrocytoma clone D384.
Biochemical Society transactions 1990;18(5):888-9.
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1990: Williams T A; Hooper N M; Kenny A J; Turner A J
Molecular forms of angiotensin-converting enzyme in brain microvessels.
Biochemical Society transactions 1990;18(5):887.
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1990: Hooper N M; Hryszko J; Turner A J
Purification and characterization of pig kidney aminopeptidase P. A glycosyl-phosphatidylinositol-anchored ectoenzyme.
The Biochemical journal 1990;267(2):509-15.
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1990: Hooper N M; Keen J N; Turner A J
Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme.
The Biochemical journal 1990;265(2):429-33.
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1990: Turner A J
Neuropeptide signalling and cell-surface peptidases.
Advances in second messenger and phosphoprotein research 1990;24():467-71.
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1989: Turner A J; Hooper N M
Phosphatidylinositol-glycan-tailed membrane proteins: the biochemistry of glycolipid anchors.
Biochemical Society transactions 1989;17(5):864-6.
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1989: Hooper N M; Turner A J
Ectoenzymes of the kidney microvillar membrane. Isolation and characterization of the amphipathic form of renal dipeptidase and hydrolysis of its glycosyl-phosphatidylinositol anchor by an activity in plasma.
The Biochemical journal 1989;261(3):811-8.
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1989: Bourne A; Barnes K; Taylor B A; Turner A J; Kenny A J
Membrane peptidases in the pig choroid plexus and on other cell surfaces in contact with the cerebrospinal fluid.
The Biochemical journal 1989;259(1):69-80.
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1989: Kirkness E F; Bovenkerk C F; Ueda T; Turner A J
Phosphorylation of gamma-aminobutyrate (GABA)/benzodiazepine receptors by cyclic AMP-dependent protein kinase.
The Biochemical journal 1989;259(2):613-6.
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1989: Littlewood G M; Hooper N M; Turner A J
Ectoenzymes of the kidney microvillar membrane. Affinity purification, characterization and localization of the phospholipase C-solubilized form of renal dipeptidase.
The Biochemical journal 1989;257(2):361-7.
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1988: Barnes K; Matsas R; Hooper N M; Turner A J; Kenny A J
Endopeptidase-24.11 is striosomally ordered in pig brain and, in contrast to aminopeptidase N and peptidyl dipeptidase A ('angiotensin converting enzyme'), is a marker for a set of striatal efferent fibres.
Neuroscience 1988;27(3):799-817.
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1988: Barnes K; Turner A J; Kenny A J
Electronmicroscopic immunocytochemistry of pig brain shows that endopeptidase-24.11 is localized in neuronal membranes.
Neuroscience letters 1988;94(1-2):64-9.
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1988: Kirkness E F; Turner A J
Antibodies directed against a nonapeptide sequence of the gamma-aminobutyrate (GABA)/benzodiazepine receptor alpha-subunit. Detection of a distinct alpha-like subunit in pig cerebral cortex but not cerebellum.
The Biochemical journal 1988;256(1):291-4.
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1988: Kirkness E F; Turner A J
The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively.
European journal of pharmacology 1988;150(3):385-8.
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1988: Hooper N M; Turner A J
Ectoenzymes of the kidney microvillar membrane. Aminopeptidase P is anchored by a glycosyl-phosphatidylinositol moiety.
FEBS letters 1988;229(2):340-4.
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1988: Hooper N M; Turner A J
Ectoenzymes of the kidney microvillar membrane. Differential solubilization by detergents can predict a glycosyl-phosphatidylinositol membrane anchor.
The Biochemical journal 1988;250(3):865-9.
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1988: Kirkness E F; Turner A J
Characterization of a cytosolic protein (P36) isolated from pig brain by benzodiazepine-affinity chromatography.
Journal of neurochemistry 1988;50(2):356-65.
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1987: Hooper N M; Keen J; Pappin D J; Turner A J
Pig kidney angiotensin converting enzyme. Purification and characterization of amphipathic and hydrophilic forms of the enzyme establishes C-terminal anchorage to the plasma membrane.
The Biochemical journal 1987;247(1):85-93.
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1987: Widdows K B; Kirkness E F; Turner A J
Modification of the GABA/benzodiazepine receptor with the arginine reagent, 2,3-butanedione.
FEBS letters 1987;222(1):125-8.
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1987: Hooper N M; Low M G; Turner A J
Renal dipeptidase is one of the membrane proteins released by phosphatidylinositol-specific phospholipase C.
The Biochemical journal 1987;244(2):465-9.
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1987: Turner A J; Hryszko J; Hooper N M; Dowdall M J
Purification and characterization of a peptidyl dipeptidase resembling angiotensin converting enzyme from the electric organ of Torpedo marmorata.
Journal of neurochemistry 1987;48(3):910-6.
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1986: Matsas R; Kenny A J; Turner A J
An immunohistochemical study of endopeptidase-24.11 ("enkephalinase") in the pig nervous system.
Neuroscience 1986;18(4):991-1012.
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1985: Matsas R; Stephenson S L; Hryszko J; Kenny A J; Turner A J
The metabolism of neuropeptides. Phase separation of synaptic membrane preparations with Triton X-114 reveals the presence of aminopeptidase N.
The Biochemical journal 1985;231(2):445-9.
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1985: Matsas R; Rattray M; Kenny A J; Turner A J
The metabolism of neuropeptides. Endopeptidase-24.11 in human synaptic membrane preparations hydrolyses substance P.
The Biochemical journal 1985;228(2):487-92.
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1985: Turner A J; Matsas R; Kenny A J
Are there neuropeptide-specific peptidases?
Biochemical pharmacology 1985;34(9):1347-56.
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1985: Turner A J; Matsas R; Kenny A J
Endopeptidase-24.11 and neuropeptide metabolism.
Biochemical Society transactions 1985;13(1):39-42.
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1984: Matsas R; Kenny A J; Turner A J
The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11.
The Biochemical journal 1984;223(2):433-40.
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1984: Matsas R; Turner A J; Kenny A J
Endopeptidase-24.11 and aminopeptidase activity in brain synaptic membranes are jointly responsible for the hydrolysis of cholecystokinin octapeptide (CCK-8).
FEBS letters 1984;175(1):124-8.
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1983: Relton J M; Gee N S; Matsas R; Turner A J; Kenny A J
Purification of endopeptidase-24.11 ('enkephalinase') from pig brain by immunoadsorbent chromatography.
The Biochemical journal 1983;215(3):519-23.
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1983: Matsas R; Fulcher I S; Kenny A J; Turner A J
Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(10):3111-5.
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1982: Fulcher I S; Matsas R; Turner A J; Kenny A J
Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors.
The Biochemical journal 1982;203(2):519-22.
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