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Jim Turpin

Research Profile

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HIV-1
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TOP 3
Janet M Young; Jim A Turpin; Runa Musib; Opendra K Sharma
Outcomes of a National Institute of Allergy and Infectious Diseases Workshop on understanding HIV-exposed but seronegative individuals.
Jim A Turpin; Marco L Schito; Lisa M Miller Jenkins; John K Inman; Ettore Appella
Topical microbicides: a promising approach for controlling the AIDS pandemic via retroviral zinc finger inhibitors.
Marco L Schito; Adam C Soloff; Danielle Slovitz; Anita M Trichel; John K Inman; Ettore Appella; Jim A Turpin; Simon M Barratt-Boyes
Preclinical evaluation of a zinc finger inhibitor targeting lentivirus nucleocapsid protein in SIV-infected monkeys.

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All Publications

2011: Janet M Young; Jim A Turpin; Runa Musib; Opendra K Sharma
Outcomes of a National Institute of Allergy and Infectious Diseases Workshop on understanding HIV-exposed but seronegative individuals.
AIDS research and human retroviruses 2011;27(7):737-43.
2008: Jim A Turpin; Marco L Schito; Lisa M Miller Jenkins; John K Inman; Ettore Appella
Topical microbicides: a promising approach for controlling the AIDS pandemic via retroviral zinc finger inhibitors.
Advances in pharmacology (San Diego, Calif.) 2008;56():229-56.
2006: Marco L Schito; Adam C Soloff; Danielle Slovitz; Anita M Trichel; John K Inman; Ettore Appella; Jim A Turpin; Simon M Barratt-Boyes
Preclinical evaluation of a zinc finger inhibitor targeting lentivirus nucleocapsid protein in SIV-infected monkeys.
Current HIV research 2006;4(3):379-86.
2006: Brigitte E Beer; Gustavo F Doncel; Fred C Krebs; Robin J Shattock; Patricia S Fletcher; Robert W Buckheit; Karen Watson; Charlene S Dezzutti; James E Cummins; Ena Bromley; Nicola Richardson-Harman; Luke A Pallansch; Carol Lackman-Smith; Clay Osterling; Marie Mankowski; Shendra R Miller; Bradley J Catalone; Patricia A Welsh; Mary K Howett; Brian Wigdahl; Jim A Turpin; Patricia Reichelderfer
In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories.
Antimicrobial agents and chemotherapy 2006;50(2):713-23.
2005: András Horváth; Szilvia Tokés; Tracy Hartman; Karen Watson; Jim A Turpin; Robert W Buckheit; Zsolt Sebestyén; János Szöllosi; Ilona Benko; Thomas J Bardos; Joseph A Dunn; László Fésüs; Ferenc D Tóth; Janos Aradi
Potent inhibition of HIV-1 entry by (s4dU)35.
Virology 2005;334(2):214-23.
2005: Toshiyuki Mori; Barry R O'Keefe; Raymond C Sowder; Scott D Bringans; Roberta S Gardella; Shannon Berg; Pamela Cochran; Jim A Turpin; Robert W Buckheit; James B McMahon; Michael R Boyd
Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp.
The Journal of biological chemistry 2005;280(10):9345-53.
2004: Pratibha Srivastava; Marco L Schito; Rasem J Fattah; Toshiaki Hara; Tracy Hartman; Robert W Buckheit; Jim A Turpin; John K Inman; Ettore Appella
Optimization of unique, uncharged thioesters as inhibitors of HIV replication.
Bioorganic & medicinal chemistry 2004;12(24):6437-50.
2004: Victor E Buckwold; Richard J H Wilson; Aysegul Nalca; Brigitte B Beer; Thomas G Voss; Jim A Turpin; Robert W Buckheit; Jiayi Wei; Michelle Wenzel-Mathers; Eve M Walton; Robert J Smith; Melanie Pallansch; Priscilla Ward; Jay Wells; Lara Chuvala; Sandra Sloane; Robin L Paulman; Julie Russell; Tracy Hartman; Roger G Ptak
Antiviral activity of hop constituents against a series of DNA and RNA viruses.
Antiviral research 2004;61(1):57-62.
2003: Xin Chen; Lu Yang; Ning Zhang; Jim A Turpin; Robert W Buckheit; Clay Osterling; Joost J Oppenheim; O M Zack Howard
Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 2003;47(9):2810-6.
2003: Barry R O'Keefe; Donald F Smee; Jim A Turpin; Carrie J Saucedo; Kirk R Gustafson; Toshiyuki Mori; Dennis Blakeslee; Robert W Buckheit; Michael R Boyd
Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin.
Antimicrobial agents and chemotherapy 2003;47(8):2518-25.
2003: Heidi R Bokesch; Barry R O'Keefe; Tawnya C McKee; Lewis K Pannell; Gregory M L Patterson; Roberta S Gardella; Raymond C Sowder; Jim A Turpin; Karen Watson; Robert W Buckheit; Michael R Boyd
A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium.
Biochemistry 2003;42(9):2578-84.
2003: Marco L Schito; Atul Goel; Yongsheng Song; John K Inman; Rasem J Fattah; William G Rice; Jim A Turpin; Alan Sher; Ettore Appella
In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model.
AIDS research and human retroviruses 2003;19(2):91-101.
2002: Nouri Neamati; Zhaiwei Lin; Rajeshri G Karki; Ann H Orr; Kiriana Cowansage; Dirk Strumberg; Godwin C G Pais; Johannes H Voigt; Marc C Nicklaus; Heather E Winslow; He Zhao; Jim A Turpin; Jizu Yi; Anna Marie Skalka; Terrence R Burke; Yves Pommier
Metal-dependent inhibition of HIV-1 integrase.
Journal of medicinal chemistry 2002;45(26):5661-70.
2002: Guozhang Xu; Arunachalam Kannan; Tracy L Hartman; Heather Wargo; Karen Watson; Jim A Turpin; Robert W Buckheit; Allison A Johnson; Yves Pommier; Mark Cushman
Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents.
Bioorganic & medicinal chemistry 2002;10(8):2807-16.
2002: Yongsheng Song; Atul Goel; venkatesha basrur; Paula E A Roberts; Judy A Mikovits; John K Inman; Jim A Turpin; William G Rice; Ettore Appella
Synthesis and biological properties of amino acid amide ligand-based pyridinioalkanoyl thioesters as anti-HIV agents.
Bioorganic & medicinal chemistry 2002;10(5):1263-73.
2002: Atul Goel; Sharlyn J Mazur; Rasem J Fattah; Tracy L Hartman; Jim A Turpin; Mingjun Huang; William G Rice; Ettore Appella; John K Inman
Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(5):767-70.
2002: Guozhang Xu; Tracy L Hartman; Heather Wargo; Jim A Turpin; Robert W Buckheit; Mark Cushman
Synthesis of alkenyldiarylmethane (ADAM) non-nucleoside HIV-1 reverse transcriptase inhibitors with non-identical aromatic rings.
Bioorganic & medicinal chemistry 2002;10(2):283-90.
2001: Guozhang Xu; M Micklatcher; Maximilian Silvestri; Tracy L Hartman; J Burrier; MC Osterling; Heather Wargo; Jim A Turpin; Robert W Buckheit; Mark Cushman
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2001;44(24):4092-113.
2001: A Casimiro-Garcia; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Loftus; Jim A Turpin; Robert W Buckheit; Phillip E Fanwick; Mark Cushman
Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments.
Bioorganic & medicinal chemistry 2001;9(11):2827-41.
2001: Guozhang Xu; TL Loftus; Heather Wargo; Jim A Turpin; Robert W Buckheit; Mark Cushman
Solid-phase synthesis of the alkenyldiarylmethane (ADAM) series of non-nucleoside HIV-1 reverse transcriptase inhibitors.
The Journal of organic chemistry 2001;66(18):5958-64.
2001: Joseph E Saavedra; Aloka Srinivasan; Challice L Bonifant; J Chu; A P Shanklin; Judith L Flippen-Anderson; W G Rice; Jim A Turpin; Keith M Davies; Larry K Keefer
The secondary amine/nitric oxide complex ion R(2)N[N(O)NO](-) as nucleophile and leaving group in S9N)Ar reactions.
The Journal of organic chemistry 2001;66(9):3090-8.
2001: K C Santhosh; G C Paul; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Loftus; Jim A Turpin; Robert W Buckheit; Mark Cushman
Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.
Journal of medicinal chemistry 2001;44(5):703-14.
2001: Robert W Buckheit; K Watson; V Fliakas-Boltz; Julie Russell; TL Loftus; MC Osterling; Jim A Turpin; Luke A Pallansch; E Lucile White; J W Lee; Sun Hwan Lee; J W Oh; H S Kwon; Sun G Chung; Eui-Hwan Cho
SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2.
Antimicrobial agents and chemotherapy 2001;45(2):393-400.
2000: K C Santhosh; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Loftus; Jim A Turpin; Robert W Buckheit; Mark Cushman
Anti-HIV activity of a series of cosalane amino acid conjugates.
Bioorganic & medicinal chemistry letters 2000;10(22):2505-8.
2000: G C Paul; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Loftus; Jim A Turpin; Robert W Buckheit; Mark Cushman
Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates.
Bioorganic & medicinal chemistry letters 2000;10(18):2149-52.
2000: venkatesha basrur; Y Song; Sharlyn J Mazur; Yuichiro Higashimoto; Jim A Turpin; William G Rice; John K Inman; Ettore Appella
Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action.
The Journal of biological chemistry 2000;275(20):14890-7.
2000: A Casimiro-Garcia; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Stup; Jim A Turpin; Robert W Buckheit; Mark Cushman
Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain.
Bioorganic & medicinal chemistry 2000;8(1):191-200.
1999: A Casimiro-Garcia; M Micklatcher; Jim A Turpin; TL Stup; K Watson; Robert W Buckheit; Mark Cushman
Novel modifications in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 1999;42(23):4861-74.
1999: Nouri Neamati; Jim A Turpin; Heather E Winslow; JL Christensen; K Williamson; Ann H Orr; William G Rice; Yves Pommier; Antonio Garofalo; Antonella Brizzi; Giuseppe Campiani; Isabella Fiorini; Vito Nacci
Thiazolothiazepine inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1999;42(17):3334-41.
1999: O M Zack Howard; A K Shirakawa; Jim A Turpin; A Maynard; G J Tobin; Mary Carrington; Joost J Oppenheim; M Dean
Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function.
The Journal of biological chemistry 1999;274(23):16228-34.
1999: Mark Cushman; S Insaf; G Paul; JA Ruell; E De Clercq; D Schols; C Pannecouque; M Witvrouw; CA Schaeffer; Jim A Turpin; K Williamson; William G Rice
Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.
Journal of medicinal chemistry 1999;42(10):1767-77.
1999: Z Lin; Nouri Neamati; Hong Zhao; Y Kiryu; Jim A Turpin; Claudia Aberham; Klaus Strebel; Kurt W Kohn; M Witvrouw; C Pannecouque; zeger debyser; E De Clercq; William G Rice; Yves Pommier; Terrence R Burke
Chicoric acid analogues as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 1999;42(8):1401-14.
1999: Jim A Turpin; Y Song; John K Inman; M Huang; Anders Wallqvist; A Maynard; David G Covell; William G Rice; Ettore Appella
Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers.
Journal of medicinal chemistry 1999;42(1):67-86.
1998: O M Zack Howard; T Korte; Nadya I Tarasova; M Grimm; Jim A Turpin; W G Rice; Christopher J Michejda; R Blumenthal; Joost J Oppenheim
Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function.
Journal of leukocyte biology 1998;64(1):6-13.
1998: O M Zack Howard; J J Oppenheim; Melinda G Hollingshead; Joseph M Covey; James C Bigelow; J J McCormack; Robert W Buckheit; DJ Clanton; Jim A Turpin; William G Rice
Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application.
Journal of medicinal chemistry 1998;41(13):2184-93.
1998: M Huang; A Maynard; Jim A Turpin; L Graham; G M Janini; David G Covell; William G Rice
Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins.
Journal of medicinal chemistry 1998;41(9):1371-81.
1998: Jim A Turpin; Robert W Buckheit; D Derse; Melinda G Hollingshead; K Williamson; C Palamone; MC Osterling; S A Hill; L Graham; CA Schaeffer; M Bu; M Huang; Wieslaw Cholody; Christopher J Michejda; William G Rice
Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription.
Antimicrobial agents and chemotherapy 1998;42(3):487-94.
1997: N B McDonnell; RN De Guzman; W G Rice; Jim A Turpin; Michael F Summers
Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS.
Journal of medicinal chemistry 1997;40(13):1969-76.
1997: M K Warren; W L Rose; J L Cone; W G Rice; Jim A Turpin
Differential infection of CD34+ cell-derived dendritic cells and monocytes with lymphocyte-tropic and monocyte-tropic HIV-1 strains.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):5035-42.
1997: William G Rice; Jim A Turpin; M Huang; DJ Clanton; Robert W Buckheit; David G Covell; Anders Wallqvist; N B McDonnell; R N DeGuzman; Michael F Summers; L Zalkow; JP Bader; R D Haugwitz; Edward A Sausville
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.
Nature medicine 1997;3(3):341-5.
1997: William G Rice; David C Baker; CA Schaeffer; L Graham; M Bu; S Terpening; DJ Clanton; R Schultz; JP Bader; Robert W Buckheit; L Field; P K Singh; Jim A Turpin
Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins.
Antimicrobial agents and chemotherapy 1997;41(2):419-26.
1996: William G Rice; Jim A Turpin; CA Schaeffer; L Graham; D Clanton; Robert W Buckheit; Daniel W Zaharevitz; Michael F Summers; Anders Wallqvist; David G Covell
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
Journal of medicinal chemistry 1996;39(19):3606-16.
1996: Jim A Turpin; S J Terpening; CA Schaeffer; G Yu; C J Glover; R L Felsted; Edward A Sausville; William G Rice
Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles.
Journal of virology 1996;70(9):6180-9.
1996: Mark Cushman; W M Golebiewski; L Graham; Jim A Turpin; William G Rice; V Fliakas-Boltz; Robert W Buckheit
Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 1996;39(16):3217-27.
1996: Jim A Turpin; CA Schaeffer; M Bu; L Graham; Robert W Buckheit; D Clanton; William G Rice
Human immunodeficiency virus type-1 (HIV-1) replication is unaffected by human secretory leukocyte protease inhibitor.
Antiviral research 1996;29(2-3):269-77.
1995: William G Rice; J G Supko; L Malspeis; Robert W Buckheit; D Clanton; M Bu; L Graham; CA Schaeffer; Jim A Turpin; J Domagala; RD Gogliotti; JP Bader; S M Halliday; Lori V Coren; Raymond C Sowder; Larry O Arthur; Louis E. Henderson
Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.
Science (New York, N.Y.) 1995;270(5239):1194-7.
1992: O M Zack Howard; M Dean; H Young; M Ramsburg; Jim A Turpin; D F Michiel; David J Kelvin; L Lee; William L Farrar
Characterization of a class 3 tyrosine kinase.
Oncogene 1992;7(5):895-900.