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Mark Tuszynski

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Mingyong Gao; Paul Lu; Dan Lynam; Jeff Sakamoto; Bridget Bednark; James M Conner; Mark H Tuszynski
Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection.
Paul Lu; Martin Marsala; Karla McHale; Ephron S Rosenzweig; Armin Blesch; John Brock; James M Conner; Mingyong Gao; Lori Graham; Leif A Havton; Yaozhi Wang; Di Wu; Binhai Zheng; Mark H Tuszynski
Long-distance growth and connectivity of neural stem cells after severe spinal cord injury.
Yvette S Nout; Ephron S Rosenzweig; Roland R Roy; Sarah C Strand; Mark H Tuszynski; Sharon Zdunowski; Hui Zhong; John H Brock; Grégoire Courtine; V Reggie Edgerton; Adam R Ferguson; Stephanie Hawbecker; Rod Moseanko; Jessica L Nielson; Michael S Beattie; Jacqueline C Bresnahan
Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey.

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2013: Mingyong Gao; Paul Lu; Dan Lynam; Jeff Sakamoto; Bridget Bednark; James M Conner; Mark H Tuszynski
Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection.
Biomaterials 2013;34(5):1529-36.
2012: Paul Lu; Martin Marsala; Karla McHale; Ephron S Rosenzweig; Armin Blesch; John Brock; James M Conner; Mingyong Gao; Lori Graham; Leif A Havton; Yaozhi Wang; Di Wu; Binhai Zheng; Mark H Tuszynski
Long-distance growth and connectivity of neural stem cells after severe spinal cord injury.
Cell 2012;150(6):1264-73.
2012: Yvette S Nout; Ephron S Rosenzweig; Roland R Roy; Sarah C Strand; Mark H Tuszynski; Sharon Zdunowski; Hui Zhong; John H Brock; Grégoire Courtine; V Reggie Edgerton; Adam R Ferguson; Stephanie Hawbecker; Rod Moseanko; Jessica L Nielson; Michael S Beattie; Jacqueline C Bresnahan
Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey.
Neurorehabilitation and neural repair 2012;26(6):556-69.
2012: Paul Lu; Ramsey Samara; Yaozhi Wang; Nina Weishaupt; Karla Banos; David Bennett; Armin Blesch; Karim Fouad; Lori Graham; Verena Haringer; Leif Havton; Mark H Tuszynski
Motor axonal regeneration after partial and complete spinal cord transection.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(24):8208-18.
2012: Mark H Tuszynski; Oswald Steward
Concepts and methods for the study of axonal regeneration in the CNS.
Neuron 2012;74(5):777-91.
2012: Armin Blesch; Giovanni Coppola; Dan Geschwind; Paul Lu; Kasper Roet; Shingo Tsukada; Laura Taylor Alto; Mark H Tuszynski
Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects.
Experimental neurology 2012;235(1):162-73.
2012: Yvette S Nout; Ephron S Rosenzweig; Roland R Roy; Sarah C Strand; Sharon Zdunowski; Michael S Beattie; Jacqueline C Bresnahan; John H Brock; Gregoire Courtine; V Reggie Edgerton; Adam R Ferguson; Stephanie Hawbecker; Rod Moseanko; Jessica L Nielson; Mark H Tuszynski
Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2012;9(2):380-92.
2012: Choya Yoon; Mark H Tuszynski
Frontiers of spinal cord and spine repair: experimental approaches for repair of spinal cord injury.
Advances in experimental medicine and biology 2012;760():1-15.
2011: Edmund R Hollis; Mark H Tuszynski
Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2011;8(4):694-703.
2011: Devin L Jindrich; Gregoire Courtine; James J Liu; Heather L McKay; Rod Moseanko; Timothy J Bernot; Roland R Roy; Hui Zhong; Mark H Tuszynski; V Reggie Edgerton
Unconstrained three-dimensional reaching in rhesus monkeys.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2011;209(1):35-50.
2011: Ling Wang; James M Conner; Jessica Rickert; Mark H Tuszynski
Structural plasticity within highly specific neuronal populations identifies a unique parcellation of motor learning in the adult brain.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2545-50.
2011: David A Merrill; Eliezer Masliah; Jeffery A Roberts; Heather McKay; Jeffrey Kordower; Elliott J Mufson; Mark H Tuszynski
Association of early experience with neurodegeneration in aged primates.
Neurobiology of aging 2011;32(1):151-6.
2010: Ephron S Rosenzweig; Gregoire Courtine; Devin L Jindrich; John H Brock; Adam R Ferguson; Sarah C Strand; Yvette S Nout; Roland R Roy; Darren M Miller; Michael S Beattie; Leif A Havton; Jacqueline C Bresnahan; V Reggie Edgerton; Mark H Tuszynski
Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury.
Nature neuroscience 2010;13(12):1505-10.
2010: James Conner; M Kulczycki; Mark H Tuszynski
Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning.
Cerebral cortex (New York, N.Y. : 1991) 2010;20(11):2739-48.
2010: Thomas Gros; Jeff S Sakamoto; Armin Blesch; Leif A Havton; Mark H Tuszynski
Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds.
Biomaterials 2010;31(26):6719-29.
2010: Edmund R Hollis; Pouya Jamshidi; Ariana O Lorenzana; Jae Lee; Steven J Gray; R Jude Samulski; Binhai Zheng; Mark H Tuszynski
Transient demyelination increases the efficiency of retrograde AAV transduction.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(8):1496-500.
2010: John H Brock; Ephron S Rosenzweig; Armin Blesch; Rod Moseanko; Leif A Havton; V Reggie Edgerton; Mark H Tuszynski
Local and remote growth factor effects after primate spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(29):9728-37.
2010: K Löw; Armin Blesch; J Herrmann; Mark H Tuszynski
A dual promoter lentiviral vector for the in vivo evaluation of gene therapeutic approaches to axon regeneration after spinal cord injury.
Gene therapy 2010;17(5):577-91.
2009: Ken Kadoya; Shingo Tsukada; Paul Lu; Giovanni Coppola; Daniel Geschwind; Marie T Filbin; Armin Blesch; Mark H Tuszynski
Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury.
Neuron 2009;64(2):165-72.
2009: JM Conner; Kevin M Franks; Andrea K Titterness; Kyle Russell; David A Merrill; Brian R Christie; Terrence J Sejnowski; Mark H Tuszynski
NGF is essential for hippocampal plasticity and learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(35):10883-9.
2009: Laura Taylor Alto; Leif A Havton; James M Conner; Armin Blesch; Edmund R Hollis; Mark H Tuszynski
Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury.
Nature neuroscience 2009;12(9):1106-13.
2009: A Blight; Armin Curt; J F Ditunno; B Dobkin; P Ellaway; J Fawcett; M Fehlings; Robert Grossman; D P Lammertse; A Privat; J Steeves; Mark H Tuszynski; M Kalichman; James Guest
Position statement on the sale of unproven cellular therapies for spinal cord injury: the international campaign for cures of spinal cord injury paralysis.
Spinal cord 2009;47(9):713-4.
2009: Ronald W Alfa; Mark H Tuszynski; Armin Blesch
A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth.
Journal of neuroscience research 2009;87(12):2624-31.
2009: Dhakshin Ramanathan; Mark H Tuszynski; JM Conner
The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(18):5992-6000.
2009: Edmund R Hollis; Pouya Jamshidi; Karin Löw; Armin Blesch; Mark H Tuszynski
Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7215-20.
2009: Ephron S Rosenzweig; John H Brock; Maya D Culbertson; Paul Lu; Rod Moseanko; V Reggie Edgerton; Leif A Havton; Mark H Tuszynski
Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys.
The Journal of comparative neurology 2009;513(2):151-63.
2009: Alan H Nagahara; David A Merrill; Giovanni Coppola; Shingo Tsukada; Brock E Schroeder; Gideon M Shaked; Ling Wang; Armin Blesch; Albert Kim; James M Conner; Edward Rockenstein; Moses V Chao; Edward H Koo; Daniel Geschwind; Eliezer Masliah; Andrea A Chiba; Mark H Tuszynski
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease.
Nature medicine 2009;15(3):331-7.
2009: Alan H Nagahara; Tim Bernot; Rod Moseanko; Laurie Brignolo; Armin Blesch; James M Conner; Anthony Ramirez; Mehdi Gasmi; Mark H Tuszynski
Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery.
Experimental neurology 2009;215(1):153-9.
2009: Armin Blesch; Mark H Tuszynski
Spinal cord injury: plasticity, regeneration and the challenge of translational drug development.
Trends in neurosciences 2009;32(1):41-7.
2009: Edmund R Hollis; Paul Lu; Armin Blesch; Mark H Tuszynski
IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury.
Experimental neurology 2009;215(1):53-9.
2008: Christopher D Herzog; Biplob Dass; Mehdi Gasmi; Roy A E Bakay; James E Stansell; Mark H Tuszynski; Krystof Bankiewicz; Er-Yun Chen; Yaping Chu; Kathie Bishop; Jeffrey Kordower; raymond bartus
Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(10):1737-44.
2008: Kathie M Bishop; Eva K Hofer; Arpesh Mehta; Anthony Ramirez; Liangwu Sun; Mark H Tuszynski; raymond bartus
Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons.
Experimental neurology 2008;211(2):574-84.
2008: ZAVEN KHACHATURIAN; Ronald C. Petersen; S Gauthier; Neil Buckholtz; Jody Corey-Bloom; Bill Evans; Howard Fillit; Norman Foster; Barry Greenberg; Michael Grundman; Mary Sano; James Simpkins; Lon S Schneider; Michael Weiner; Douglas Galasko; Bradley T Hyman; Lew Kuller; Dale Schenk; Stephen Snyder; Ronald Thomas; Mark H Tuszynski; Bruno Vellas; Richard J Wurtman; Peter J Snyder; Richard A Frank; Marilyn S Albert; Rachelle S Doody; Steven H Ferris; Jeffrey A Kaye; Edward H Koo; Marcelle Morrison-Bogorad; Barry Reisberg; David P Salmon; Sid Gilman; Richard C Mohs; Paul S Aisen; John C S Breitner; Jeffrey L Cummings; Claudia Kawas; Creighton Phelps; Judes Poirier; Marwan Sabbagh; Jacques Touchon; Ara Khachaturian; Lisa J Bain
A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(3):156-63.
2008: Edmund R Hollis; Ken Kadoya; Matthew Hirsch; R Jude Samulski; Mark H Tuszynski
Efficient retrograde neuronal transduction utilizing self-complementary AAV1.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):296-301.
2008: Paul Lu; Mark H Tuszynski
Growth factors and combinatorial therapies for CNS regeneration.
Experimental neurology 2008;209(2):313-20.
2008: Karin Löw; Maya Culbertson; Frank Bradke; Marc Tessier-Lavigne; Mark H Tuszynski
Netrin-1 is a novel myelin-associated inhibitor to axon growth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(5):1099-108.
2007: Eric Alton; Stefano Ferrari; Uta Griesenbach; A Aiuti; A C Bachoud-Lévi; Armin Blesch; M K Brenner; F Cattaneo; E A Chiocca; G Gao; K A High; A M Leen; Nick Lemoine; I A McNeish; G Meneguzzi; M Peschanski; M G Roncarolo; D S Strayer; Mark H Tuszynski; D J Waxman; J M Wilson
Progress and prospects: gene therapy clinical trials (part 2).
Gene therapy 2007;14(22):1555-63.
2007: Mark H Tuszynski
Rebuilding the brain: resurgence of fetal grafting.
Nature neuroscience 2007;10(10):1229-30.
2007: Armin Blesch; Mark H Tuszynski
Transient growth factor delivery sustains regenerated axons after spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(39):10535-45.
2007: Mark H Tuszynski
Nerve growth factor gene delivery: animal models to clinical trials.
Developmental neurobiology 2007;67(9):1204-15.
2007: Christopher D Herzog; Biplob Dass; James E Holden; James Stansell; Mehdi Gasmi; Mark H Tuszynski; raymond bartus; Jeffrey Kordower
Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys.
Movement disorders : official journal of the Movement Disorder Society 2007;22(8):1124-32.
2007: Mark H Tuszynski
Nerve growth factor gene therapy in Alzheimer disease.
Alzheimer disease and associated disorders 2007;21(2):179-89.
2007: James W Fawcett; Armin Curt; John D Steeves; William P Coleman; Mark H Tuszynski; Daniel P Lammertse; PF Bartlett; Andrew R Blight; V Dietz; John F Ditunno; BH Dobkin; Leif A Havton; Peter H Ellaway; MG Fehlings; A Privat; Robert Grossman; James Guest; N Kleitman; M Nakamura; Manuel Gaviria; Deborah J Short
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials.
Spinal cord 2007;45(3):190-205.
2007: John D Steeves; Daniel P Lammertse; Armin Curt; James W Fawcett; Mark H Tuszynski; John F Ditunno; Peter H Ellaway; MG Fehlings; James Guest; N Kleitman; PF Bartlett; Andrew R Blight; V Dietz; BH Dobkin; Robert Grossman; Deborah J Short; M Nakamura; William P Coleman; Manuel Gaviria; A Privat
Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures.
Spinal cord 2007;45(3):206-21.
2007: Mark H Tuszynski; John D Steeves; James W Fawcett; Daniel P Lammertse; M Kalichman; C Rask; Armin Curt; John F Ditunno; MG Fehlings; James Guest; Peter H Ellaway; N Kleitman; PF Bartlett; Andrew R Blight; V Dietz; BH Dobkin; Robert Grossman; A Privat
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics.
Spinal cord 2007;45(3):222-31.
2007: Daniel P Lammertse; Mark H Tuszynski; John D Steeves; Armin Curt; James W Fawcett; C Rask; John F Ditunno; MG Fehlings; James Guest; Peter H Ellaway; N Kleitman; Andrew R Blight; BH Dobkin; Robert Grossman; H Katoh; A Privat; M Kalichman
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design.
Spinal cord 2007;45(3):232-42.
2007: raymond bartus; Christopher D Herzog; Kathie Bishop; Jeffrey M Ostrove; Mark H Tuszynski; Jeffrey Kordower; Mehdi Gasmi
Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point.
Parkinsonism & related disorders 2007;13 Suppl 3():S469-77.
2007: Paul Lu; Leonard L Jones; Mark H Tuszynski
Axon regeneration through scars and into sites of chronic spinal cord injury.
Experimental neurology 2007;203(1):8-21.
2006: Mathew Blurton-Jones; Mark H Tuszynski
Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF.
The Journal of comparative neurology 2006;499(4):603-12.
2006: Mark H Tuszynski
Challenges to the report of Nogo antibody effects in primates.
Nature medicine 2006;12(11):1231-2; author reply 1232-3.
2006: Paul Lu; Hong Yang; Maya Culbertson; Lori Graham; A Jane Roskams; Mark H Tuszynski
Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(43):11120-30.
2006: Shula Stokols; Jeff Sakamoto; Chris Breckon; Todd Holt; James Weiss; Mark H Tuszynski
Templated agarose scaffolds support linear axonal regeneration.
Tissue engineering 2006;12(10):2777-87.
2006: Laura Taylor; Leonard Jones; Mark H Tuszynski; Armin Blesch
Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(38):9713-21.
2006: Dhakshin Ramanathan; James Conner; Mark H Tuszynski
A form of motor cortical plasticity that correlates with recovery of function after brain injury.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11370-5.
2006: Andrew R Blight; Mark H Tuszynski
Clinical trials in spinal cord injury.
Journal of neurotrauma 2006;23(3-4):586-93.
2006: Hong Yang; Paul Lu; Heather M McKay; Tim Bernot; Hans S Keirstead; Oswald Steward; Fred H Gage; V Reggie Edgerton; Mark H Tuszynski
Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(8):2157-66.
2006: Shula Stokols; Mark H Tuszynski
Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury.
Biomaterials 2006;27(3):443-51.
2005: Grégoire Courtine; Roland R Roy; Joseph Raven; John Hodgson; Heather McKay; Hong Yang; Hui Zhong; Mark H Tuszynski; V Reggie Edgerton
Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta).
Brain : a journal of neurology 2005;128(Pt 10):2338-58.
2005: DK Anderson; M Beattie; Armin Blesch; J Bresnahan; Mary Bartlett Bunge; W Dalton Dietrich; V Dietz; BH Dobkin; J Fawcett; MG Fehlings; Itzhak Fischer; Robert Grossman; James Guest; Theo Hagg; Edward D Hall; J Houle; N Kleitman; JOHN MCDONALD; M Murray; A Privat; Paul J Reier; John D Steeves; O Steward; W Tetzlaff; Mark H Tuszynski; S G Waxman; S Whittemore; J Wolpaw; Wise Young; B Zheng
Recommended guidelines for studies of human subjects with spinal cord injury.
Spinal cord 2005;43(8):453-8.
2005: Armin Blesch; James Conner; Alexander Pfeifer; Mehdi Gasmi; Anthony Ramirez; William Britton; Ron Alfa; Inder M Verma; Mark H Tuszynski
Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(6):916-25.
2005: Paul Lu; Mark H Tuszynski
Can bone marrow-derived stem cells differentiate into functional neurons?
Experimental neurology 2005;193(2):273-8.
2005: Grégoire Courtine; Roland R Roy; John Hodgson; Heather McKay; Joseph Raven; Hui Zhong; Hong Yang; Mark H Tuszynski; V Reggie Edgerton
Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus).
Journal of neurophysiology 2005;93(6):3127-45.
2005: Mark H Tuszynski; Leon J Thal; Mary Pay; David P Salmon; Hoi Sang U; Roy A E Bakay; Piyush Patel; Armin Blesch; H Lee Vahlsing; Gilbert Ho; Gang Tong; Steven G Potkin; James Fallon; Lawrence A Hansen; Elliott J Mufson; Jeffrey Kordower; Christine M Gall; James Conner
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease.
Nature medicine 2005;11(5):551-5.
2005: James Conner; Andrea A Chiba; Mark H Tuszynski
The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury.
Neuron 2005;46(2):173-9.
2005: P Lu; L L Jones; Mark H Tuszynski
BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury.
Experimental neurology 2005;191(2):344-60.
2005: Mark H Tuszynski
New strategies for CNS repair.
Ernst Schering Research Foundation workshop 2005;(53):1-10.
2004: Shula Stokols; Mark H Tuszynski
The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury.
Biomaterials 2004;25(27):5839-46.
2004: John D Steeves; J Fawcett; Mark H Tuszynski
Report of international clinical trials workshop on spinal cord injury February 20-21, 2004, Vancouver, Canada.
Spinal cord 2004;42(10):591-7.
2004: Paul Lu; Armin Blesch; Mark H Tuszynski
Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact?
Journal of neuroscience research 2004;77(2):174-91.
2004: Paul Lu; Hong Yang; Leonard L Jones; Marie T Filbin; Mark H Tuszynski
Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(28):6402-9.
2004: Armin Blesch; Mark H Tuszynski
Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury.
Yonsei medical journal 2004;45 Suppl():28-31.
2004: Jaime Imitola; Kook In Park; yang teng; Sahar Nisim; Mahesh Lachyankar; Jitka Ourednik; Franz-Josef Mueller; Rene Yiou; Anthony Atala; Richard L Sidman; Mark H Tuszynski; Samia J Khoury; Evan Y Snyder
Stem cells: cross-talk and developmental programs.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004;359(1445):823-37.
2004: Steve Lacroix; Leif A Havton; Heather McKay; Hong Yang; Adam Brant; Jeffrey Roberts; Mark H Tuszynski
Bilateral corticospinal projections arise from each motor cortex in the macaque monkey: a quantitative study.
The Journal of comparative neurology 2004;473(2):147-61.
2004: Alan Nagahara; Mark H Tuszynski
The ageless question--what accounts for age-related cognitive decline?
Science of aging knowledge environment : SAGE KE 2004;2004(19):pe20.
2004: David E Smith; Peter R Rapp; Heather M McKay; Jeffrey A Roberts; Mark H Tuszynski
Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(18):4373-81.
2004: Armin Blesch; Mark H Tuszynski
Nucleus hears axon's pain.
Nature medicine 2004;10(3):236-7.
2004: Mathew Blurton-Jones; P N Kuan; Mark H Tuszynski
Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression.
The Journal of comparative neurology 2004;468(3):347-60.
2004: Mark H Tuszynski; Armin Blesch
Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease.
Progress in brain research 2004;146():441-9.
2003: Armin Blesch; Mark H Tuszynski
Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination.
The Journal of comparative neurology 2003;467(3):403-17.
2003: Christopher A Tobias; Jed S Shumsky; M Shibata; Mark H Tuszynski; Itzhak Fischer; Alan Tessler; Marion Murray
Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration.
Experimental neurology 2003;184(1):97-113.
2003: Leonard L Jones; Dana Sajed; Mark H Tuszynski
Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(28):9276-88.
2003: Leonard L Jones; Richard U Margolis; Mark H Tuszynski
The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury.
Experimental neurology 2003;182(2):399-411.
2003: Mark H Tuszynski
Gene therapy for neurological disease.
Expert opinion on biological therapy 2003;3(5):815-28.
2003: James Conner; Andrew Culberson; Christine Packowski; Andrea A Chiba; Mark H Tuszynski
Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning.
Neuron 2003;38(5):819-29.
2003: Paul Lu; Leonard L Jones; E Y Snyder; Mark H Tuszynski
Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury.
Experimental neurology 2003;181(2):115-29.
2003: Mark H Tuszynski; Ray Grill; Leonard L Jones; Adam Brant; Armin Blesch; Karin Löw; Steve Lacroix; Paul Lu
NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection.
Experimental neurology 2003;181(1):47-56.
2003: David A Merrill; Rajiv Karim; Michael Darraq; Andrea A Chiba; Mark H Tuszynski
Hippocampal cell genesis does not correlate with spatial learning ability in aged rats.
The Journal of comparative neurology 2003;459(2):201-7.
2002: Steve Lacroix; Leon Chang; Stefan Rose-John; Mark H Tuszynski
Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth.
The Journal of comparative neurology 2002;454(3):213-28.
2002: Mark H Tuszynski; Hoi Sang U; John Alksne; Roy A E Bakay; Mary Margaret Pay; David Merrill; Leon J Thal
Growth factor gene therapy for Alzheimer disease.
Neurosurgical focus 2002;13(5):e5.
2002: Mathew Blurton-Jones; Mark H Tuszynski
Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats.
The Journal of comparative neurology 2002;452(3):276-87.
2002: Mark H Tuszynski; Leon J Thal; Hoi Sang U; Mary Margaret Pay; Armin Blesch; James Conner; H Lee Vahlsing
Nerve growth factor gene therapy for Alzheimer's disease.
Journal of molecular neuroscience : MN 2002;19(1-2):207.
2002: Mark H Tuszynski; Ray Grill; Leonard L Jones; Heather M McKay; Armin Blesch
Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts.
The Journal of comparative neurology 2002;449(1):88-101.
2002: Leonard L Jones; Mark H Tuszynski
Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(11):4611-24.
2002: Mark H Tuszynski
Growth-factor gene therapy for neurodegenerative disorders.
Lancet neurology 2002;1(1):51-7.
2002: Armin Blesch; Paul Lu; Mark H Tuszynski
Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair.
Brain research bulletin 2002;57(6):833-8.
2002: Leonard L Jones; Yu Yamaguchi; William B Stallcup; Mark H Tuszynski
NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(7):2792-803.
2002: David A Merrill; Armin Blesch; Mark H Tuszynski
Therapeutic potential of nervous system growth factors for neurodegenerative disease.
Expert review of neurotherapeutics 2002;2(1):89-96.
2002: Armin Blesch; Mark H Tuszynski
Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury.
Progress in brain research 2002;137():415-23.
2002: Mark H Tuszynski; James Conner; Armin Blesch; David Smith; David A Merrill; H Lee Vahlsing
New strategies in neural repair.
Progress in brain research 2002;138():401-9.
2002: N Weidner; Mark H Tuszynski
Spontaneous plasticity in the injured spinal cord-implications for repair strategies.
Molecular psychiatry 2002;7(1):9-11.
2001: David A Merrill; Andrea A Chiba; Mark H Tuszynski
Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats.
The Journal of comparative neurology 2001;438(4):445-56.
2001: Leonard L Jones; Mark H Tuszynski
Chronic intrathecal infusions after spinal cord injury cause scarring and compression.
Microscopy research and technique 2001;54(5):317-24.
2001: P Lu; Armin Blesch; Mark H Tuszynski
Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons.
The Journal of comparative neurology 2001;436(4):456-70.
2001: Armin Blesch; Mark H Tuszynski
GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection.
The Journal of comparative neurology 2001;436(4):399-410.
2001: Armin Blesch; James Conner; Mark H Tuszynski
Modulation of neuronal survival and axonal growth in vivo by tetracycline-regulated neurotrophin expression.
Gene therapy 2001;8(12):954-60.
2001: Leonard L Jones; MARTIN OUDEGA; Mary Bartlett Bunge; Mark H Tuszynski
Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury.
The Journal of physiology 2001;533(Pt 1):83-9.
2001: Mathew Blurton-Jones; Mark H Tuszynski
Reactive astrocytes express estrogen receptors in the injured primate brain.
The Journal of comparative neurology 2001;433(1):115-23.
2001: Norbert Weidner; A Ner; N Salimi; Mark H Tuszynski
Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3513-8.
2001: James Conner; M A Darracq; J Roberts; Mark H Tuszynski
Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1941-6.
2000: M Bowes; Mark H Tuszynski; J Conner; Justin A Zivin
Continuous intrathecal fluid infusions elevate nerve growth factor levels and prevent functional deficits after spinal cord ischemia.
Brain research 2000;883(2):178-83.
2000: Mark H Tuszynski
Intraparenchymal NGF infusions rescue degenerating cholinergic neurons.
Cell transplantation 2000;9(5):629-36.
2000: David A Merrill; J A Roberts; Mark H Tuszynski
Conservation of neuron number and size in entorhinal cortex layers II, III, and V/VI of aged primates.
The Journal of comparative neurology 2000;422(3):396-401.
2000: Armin Blesch; H S Uy; N Diergardt; Mark H Tuszynski
Neurite outgrowth can be modulated in vitro using a tetracycline-repressible gene therapy vector expressing human nerve growth factor.
Journal of neuroscience research 2000;59(3):402-9.
2000: Steve Lacroix; Mark H Tuszynski
Neurotrophic factors and gene therapy in spinal cord injury.
Neurorehabilitation and neural repair 2000;14(4):265-75.
1999: Norbert Weidner; Ray Grill; Mark H Tuszynski
Elimination of basal lamina and the collagen "scar" after spinal cord injury fails to augment corticospinal tract regeneration.
Experimental neurology 1999;160(1):40-50.
1999: Norbert Weidner; Armin Blesch; Ray Grill; Mark H Tuszynski
Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1.
The Journal of comparative neurology 1999;413(4):495-506.
1999: Douglas E Smith; J Roberts; Fred H Gage; Mark H Tuszynski
Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10893-8.
1999: Mark H Tuszynski; K Gabriel; K Gerhardt; S Szollar
Human spinal cord retains substantial structural mass in chronic stages after injury.
Journal of neurotrauma 1999;16(6):523-31.
1999: Armin Blesch; H S Uy; Ray Grill; JG Cheng; Paul H Patterson; Mark H Tuszynski
Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(9):3556-66.
1999: Mathew Blurton-Jones; J A Roberts; Mark H Tuszynski
Estrogen receptor immunoreactivity in the adult primate brain: neuronal distribution and association with p75, trkA, and choline acetyltransferase.
The Journal of comparative neurology 1999;405(4):529-42.
1999: Mark H Tuszynski; R Edgerton; B Dobkin
Recovery of locomotion after experimental spinal cord injury: axonal regeneration or modulation of intrinsic spinal cord walking circuitry?
The journal of spinal cord medicine 1999;22(2):143.
1998: Mark H Tuszynski; D E Smith; J Roberts; Heather McKay; Elliott J Mufson
Targeted intraparenchymal delivery of human NGF by gene transfer to the primate basal forebrain for 3 months does not accelerate beta-amyloid plaque deposition.
Experimental neurology 1998;154(2):573-82.
1998: Mark H Tuszynski; Norbert Weidner; M McCormack; I Miller; H Powell; J Conner
Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination.
Cell transplantation 1998;7(2):187-96.
1998: Armin Blesch; Ray Grill; Mark H Tuszynski
Neurotrophin gene therapy in CNS models of trauma and degeneration.
Progress in brain research 1998;117():473-84.
1997: Mark H Tuszynski
Gene therapy for nervous system disease.
Annals of the New York Academy of Sciences 1997;835():1-11.
1997: Ray Grill; Armin Blesch; Mark H Tuszynski
Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells.
Experimental neurology 1997;148(2):444-52.
1997: Ray Grill; K Murai; Armin Blesch; Fred H Gage; Mark H Tuszynski
Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(14):5560-72.
1997: Jamie L Eberling; J A Roberts; P R Rapp; Mark H Tuszynski; William J Jagust
Cerebral glucose metabolism and memory in aged rhesus macaques.
Neurobiology of aging 1997;18(4):437-43.
1997: Mark H Tuszynski; K Murai; Armin Blesch; Ray Grill; I Miller
Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord.
Cell transplantation 1997;6(3):361-8.
1997: Jürgen Winkler; G A Ramirez; H G Kuhn; D A Peterson; P A Day-Lollini; G R Stewart; Mark H Tuszynski; Fred H Gage; Leon J Thal
Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor.
Annals of neurology 1997;41(1):82-93.
1996: Leon J Thal; A Carta; W R Clarke; Steven H Ferris; Robert P Friedland; Ronald C. Petersen; J W Pettegrew; E Pfeiffer; Murray A Raskind; Mary Sano; Mark H Tuszynski; Robert F Woolson
A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease.
Neurology 1996;47(3):705-11.
1996: Mark H Tuszynski; E Mafong; S Meyer
Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons.
Neuroscience 1996;71(3):761-71.
1996: Mark H Tuszynski; J Roberts; MC Senut; H S U; Fred H Gage
Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration.
Gene therapy 1996;3(4):305-14.
1996: Y Nakahara; Fred H Gage; Mark H Tuszynski
Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord.
Cell transplantation 1996;5(2):191-204.
1996: Mark H Tuszynski; F H Gage
Somatic gene therapy for nervous system disease.
Ciba Foundation symposium 1996;196():85-94; discussion 94-7.
1996: Mark H Tuszynski; K Gabriel; Fred H Gage; ST Suhr; S Meyer; A Rosetti
Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury.
Experimental neurology 1996;137(1):157-73.
1995: MC Senut; Mark H Tuszynski; H K Raymon; ST Suhr; N H Liou; K R Jones; Louis F Reichardt; Fred H Gage
Regional differences in responsiveness of adult CNS axons to grafts of cells expressing human neurotrophin 3.
Experimental neurology 1995;135(1):36-55.
1995: Mark H Tuszynski; Fred H Gage
Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4621-5.
1995: Mark H Tuszynski; Fred H Gage
Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy.
Molecular neurobiology 1995;10(2-3):151-67.
1995: Armin Blesch; Mark H Tuszynski
Ex vivo gene therapy for Alzheimer's disease and spinal cord injury.
Clinical neuroscience (New York, N.Y.) 1995;3(5):268-74.
1994: Mark H Tuszynski; MC Senut; Jasodhara Ray; J Roberts
Somatic gene transfer to the adult primate central nervous system: in vitro and in vivo characterization of cells genetically modified to secrete nerve growth factor.
Neurobiology of disease 1994;1(1-2):67-78.
1994: Mark H Tuszynski; D A Peterson; Jasodhara Ray; A Baird; Y Nakahara; F H Gage
Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord.
Experimental neurology 1994;126(1):1-14.
1994: Mark H Tuszynski; Fred H Gage
Neurotrophic factors and diseases of the nervous system.
Annals of neurology 1994;35 Suppl():S9-12.
1992: B Hainline; Mark H Tuszynski; Jerome B Posner
Ataxia in epidural spinal cord compression.
Neurology 1992;42(11):2193-5.
1991: Mark H Tuszynski; H Sang; K Yoshida; Fred H Gage
Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain.
Annals of neurology 1991;30(5):625-36.
1991: F H Gage; Mark H Tuszynski; K S Chen; A M Fagan; Gerry Higgins
Nerve growth factor function in the central nervous system.
Current topics in microbiology and immunology 1991;165():71-93.
1991: Mark H Tuszynski; F H Gage
In vivo assay of neuron-specific effects of nerve growth factor.
Methods in enzymology 1991;198():35-48.
1990: Mark H Tuszynski; H S U; David G Amaral; Fred H Gage
Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(11):3604-14.
1990: J Barnett; P Baecker; C Routledge-Ward; H Bursztyn-Pettegrew; J Chow; B Nguyen; C Bach; H Chan; Mark H Tuszynski; K Yoshida
Human beta nerve growth factor obtained from a baculovirus expression system has potent in vitro and in vivo neurotrophic activity.
Experimental neurology 1990;110(1):11-24.
1990: Mark H Tuszynski; D M Armstrong; Fred H Gage
Basal forebrain cell loss following fimbria/fornix transection.
Brain research 1990;508(2):241-8.
1990: Mark H Tuszynski; F H Gage
Potential use of neurotrophic agents in the treatment of neurodegenerative disorders.
Acta neurobiologiae experimentalis 1990;50(4-5):311-22.
1990: Fred H Gage; M B Rosenberg; Mark H Tuszynski; K Yoshida; D M Armstrong; R C Hayes; Theodore Friedmann
Gene therapy in the CNS: intracerebral grafting of genetically modified cells.
Progress in brain research 1990;86():205-17.
1990: Fred H Gage; Lisa J Fisher; Hyder A Jinnah; M B Rosenberg; Mark H Tuszynski; Theodore Friedmann
Grafting genetically modified cells to the brain: conceptual and technical issues.
Progress in brain research 1990;82():1-10.
1990: Mark H Tuszynski; Gyorgy Buzsaki; Fred H Gage
Nerve growth factor infusions combined with fetal hippocampal grafts enhance reconstruction of the lesioned septohippocampal projection.
Neuroscience 1990;36(1):33-44.
1989: Mark H Tuszynski; Hyder A Jinnah; Fred H Gage
Delivery of neuroactive compounds to the brain: potential utility of genetically modified cells.
Neurobiology of aging 1989;10(5):644-5; discussion 648-50.
1989: K S Chen; Mark H Tuszynski; Fred H Gage
Role of neurotrophic factors in Alzheimer's disease.
Neurobiology of aging 1989;10(5):545-6; discussion 552-3.
1989: Mark H Tuszynski; Carol K Petito; D E Levy
Risk factors and clinical manifestations of pathologically verified lacunar infarctions.
Stroke; a journal of cerebral circulation 1989;20(8):990-9.
1989: Fred H Gage; Mark H Tuszynski; K S Chen; D Armstrong; György Buzsáki
Survival, growth and function of damaged cholinergic neurons.
EXS 1989;57():259-74.
1988: M B Rosenberg; Theodore Friedmann; R C Robertson; Mark H Tuszynski; J A Wolff; X O Breakefield; Fred H Gage
Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression.
Science (New York, N.Y.) 1988;242(4885):1575-8.
1988: Mark H Tuszynski; Carol K Petito
Ischemic thalamic aphasia with pathologic confirmation.
Neurology 1988;38(5):800-2.