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Yves Boucher

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TOP 3
Jieqiong Liu; Kamila Naxerova; Marek Ancukiewicz; Yves Boucher; Wei Chen; Benjamin Diop-Frimpong; Shom Goel; Rakesh K Jain; Shan Liao; Lei Xu
TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Triantafyllos Stylianopoulos; Nabeel Bardeesy; Yves Boucher; Vikash P Chauhan; Benjamin Diop-Frimpong; Cristina R Ferrone; Francis J Hornicek; Saloni R Jain; John D Martin; Lance L Munn; Barbara L Smith; Rakesh K Jain
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Janet M Tse; James A Tyrrell; Sarah A Wilcox-Adelman; Yves Boucher; Gang Cheng; Rakesh K Jain; Lance L Munn
Mechanical compression drives cancer cells toward invasive phenotype.

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All Publications

2012: Jieqiong Liu; Kamila Naxerova; Marek Ancukiewicz; Yves Boucher; Wei Chen; Benjamin Diop-Frimpong; Shom Goel; Rakesh K Jain; Shan Liao; Lei Xu
TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(41):16618-23.
2012: Triantafyllos Stylianopoulos; Nabeel Bardeesy; Yves Boucher; Vikash P Chauhan; Benjamin Diop-Frimpong; Cristina R Ferrone; Francis J Hornicek; Saloni R Jain; John D Martin; Lance L Munn; Barbara L Smith; Rakesh K Jain
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15101-8.
2012: Janet M Tse; James A Tyrrell; Sarah A Wilcox-Adelman; Yves Boucher; Gang Cheng; Rakesh K Jain; Lance L Munn
Mechanical compression drives cancer cells toward invasive phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(3):911-6.
2012: Chandrajit P Raut; Johanna Lahdenranta; Jeffrey A Morgan; Richard Quek; Marek Ancukiewicz; Yves Boucher; George D Demetri; Dan G Duda; J Paul Eder; Rakesh K Jain
Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).
PloS one 2012;7(2):e26331.
2011: Jean Y Perentes; Dennis Sgroi; Christine M Shaver; Eve Y Smith; Igor Garkavtsev; Rakesh K Jain; Nathaniel D Kirkpatrick; Lance L Munn; Satoshi Nagano; Yves Boucher
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Cancer research 2011;71(13):4527-38.
2011: Benjamin Diop-Frimpong; Vikash P Chauhan; Stephen Krane; Yves Boucher; Rakesh K Jain
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2909-14.
2011: Vikash P Chauhan; Yves Boucher; Triantafyllos Stylianopoulos; Rakesh K Jain
Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
Annual review of chemical and biomolecular engineering 2011;2():281-98.
2009: Vikash P Chauhan; Ryan M Lanning; Benjamin Diop-Frimpong; Wilson Mok; Edward B Brown; Timothy P Padera; Yves Boucher; Rakesh K Jain
Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.
Biophysical journal 2009;97(1):330-6.
2009: Christopher G Willett; Dan G Duda; Emmanuelle di Tomaso; Yves Boucher; Marek Ancukiewicz; Dushyant V Sahani; Johanna Lahdenranta; Daniel C Chung; Alan J Fischman; Gregory Y Lauwers; Paul Shellito; Brian G Czito; Terence Z Wong; Erik Paulson; Martin Poleski; Zeljko Vujaskovic; Rex Bentley; Helen X Chen; Jeffrey W Clark; Rakesh K Jain
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(18):3020-6.
2009: Jean Y Perentes; Trevor McKee; Carsten D Ley; Hannah Mathiew; Michelle Dawson; Timothy P Padera; Lance L Munn; Rakesh K Jain; Yves Boucher
In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Nature methods 2009;6(2):143-5.
2008: Satoshi Nagano; Jean Yannis Perentes; Rakesh K Jain; Yves Boucher
Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Cancer research 2008;68(10):3795-802.
2007: Wilson Mok; Yves Boucher; Rakesh K Jain
Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer research 2007;67(22):10664-8.
2007: Sergey V Kozin; Frank Winkler; Igor Garkavtsev; Daniel J Hicklin; Rakesh K Jain; Yves Boucher
Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.
Cancer research 2007;67(11):5076-82.
2007: Kazuhiko Ogawa; Yves Boucher; Satoshi Kashiwagi; Dai Fukumura; David Chen; Leo E Gerweck
Influence of tumor cell and stroma sensitivity on tumor response to radiation.
Cancer research 2007;67(9):4016-21.
2007: Christopher G Willett; Dan G Duda; Emmanuelle di Tomaso; Yves Boucher; Brian G Czito; Zeljko Vujaskovic; Gordana Vlahovic; Johanna C Bendell; Kenneth S Cohen; Herbert I Hurwitz; Rex Bentley; Gregory Y Lauwers; Martin Poleski; Terence Z Wong; erik paulson; Kirk A Ludwig; Rakesh K Jain
Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.
Nature clinical practice. Oncology 2007;4(5):316-21.
2006: Christopher G Willett; Sergey V Kozin; Dan G Duda; Emmanuelle di Tomaso; Kevin R Kozak; Yves Boucher; Rakesh K Jain
Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.
Seminars in oncology 2006;33(5 Suppl 10):S35-40.
2006: Trevor McKee; Paola Grandi; Wilson Mok; Georgios Alexandrakis; Numpon Insin; John P Zimmer; Moungi G Bawendi; Yves Boucher; Xandra O Breakefield; Rakesh K Jain
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Cancer research 2006;66(5):2509-13.
2005: Christopher G Willett; Yves Boucher; Dan G Duda; Emmanuelle di Tomaso; Lance L Munn; Ricky T Tong; Sergey V Kozin; Lucine Petit; Rakesh K Jain; Daniel C Chung; Dushyant V Sahani; Sanjeeva Kalva; Kenneth S Cohen; David T Scadden; Alan J Fischman; jeffrey clark; David P Ryan; Andrew X Zhu; Lawrence S Blaszkowsky; Paul C Shellito; Mari Mino-Kenudson; Gregory Y Lauwers
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(31):8136-9.
2005: Zoe N Demou; Michael Awad; Trevor McKee; Jean Yannis Perentes; Xiaoye Wang; Lance L Munn; Rakesh K Jain; Yves Boucher
Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Cancer research 2005;65(13):5674-82.
2005: Alphonse G Taghian; Rita Abi-Raad; Sherif I Assaad; Adrian Casty; Marek Ancukiewicz; Eren Yeh; Peryhan Molokhia; Khaled Attia; Timothy Sullivan; Irene Kuter; Yves Boucher; Simon Nicholas Powell
Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(9):1951-61.
2005: Igor Garkavtsev; Yves Boucher
An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol.
Cancer biology & therapy 2005;4(1):48-9.
2004: Ricky T Tong; Yves Boucher; Sergey V Kozin; Frank Winkler; Daniel J Hicklin; Rakesh K Jain
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.
Cancer research 2004;64(11):3731-6.
2004: Edward B Brown; Yves Boucher; Selim Nasser; Rakesh K Jain
Measurement of macromolecular diffusion coefficients in human tumors.
Microvascular research 2004;67(3):231-6.
2004: Christopher G Willett; Yves Boucher; Emmanuelle di Tomaso; Dan G Duda; Lance L Munn; Ricky T Tong; Daniel C Chung; Dushyant V Sahani; Sanjeeva Kalva; Sergey V Kozin; Mari Mino; Kenneth S Cohen; David T Scadden; Alan C Hartford; Alan J Fischman; jeffrey clark; David P Ryan; Andrew X Zhu; Lawrence S Blaszkowsky; Helen X Chen; Paul C Shellito; Gregory Y Lauwers; Rakesh K Jain
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.
Nature medicine 2004;10(2):145-7.
2004: Georgios Alexandrakis; Edward B Brown; Ricky T Tong; Trevor McKee; Robert B Campbell; Yves Boucher; Rakesh K Jain
Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.
Nature medicine 2004;10(2):203-7.
2003: Timothy P Padera; Yves Boucher; Rakesh K Jain
Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.
Cancer research 2003;63(23):8555-6; author reply 8558.
2003: Cynthia A Znati; Maury Rosenstein; Trevor McKee; Edward Brown; David Turner; William D Bloomer; Simon Watkins; Rakesh K Jain; Yves Boucher
Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5508-13.
2003: Tiina Roose; Paolo A Netti; Lance L Munn; Yves Boucher; Rakesh K Jain
Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled.
Microvascular research 2003;66(3):204-12.
2003: Edward Brown; Trevor McKee; Emmanuelle diTomaso; Alain Pluen; Brian Seed; Yves Boucher; Rakesh K Jain
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Nature medicine 2003;9(6):796-800.
2002: Saroja Ramanujan; Alain Pluen; Trevor McKee; Edward B Brown; Yves Boucher; Rakesh K Jain
Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Biophysical journal 2002;83(3):1650-60.
2002: Timothy P Padera; Ananth Kadambi; Emmanuelle di Tomaso; Carla Mouta Carreira; Edward B Brown; Yves Boucher; Noah C Choi; Douglas J Mathisen; John Wain; Eugene J Mark; Lance L Munn; Rakesh K Jain
Lymphatic metastasis in the absence of functional intratumor lymphatics.
Science (New York, N.Y.) 2002;296(5574):1883-6.
2002: Chieko Koike; Trevor McKee; Alain Pluen; Saroja Ramanujan; K Burton; Lance L Munn; Yves Boucher; Rakesh K Jain
Solid stress facilitates spheroid formation: potential involvement of hyaluronan.
British journal of cancer 2002;86(6):947-53.
2001: Carla Mouta Carreira; S M Nasser; Emmanuelle di Tomaso; Timothy P Padera; Yves Boucher; S I Tomarev; Rakesh K Jain
LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Cancer research 2001;61(22):8079-84.
2001: C de L Davies; Robert J Melder; Lance L Munn; Carla Mouta Carreira; Rakesh K Jain; Yves Boucher
Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.
Microvascular research 2001;62(1):26-42.
2001: Alain Pluen; Yves Boucher; Saroja Ramanujan; Trevor McKee; Takeshi Gohongi; Emmanuelle di Tomaso; Edward B Brown; Yotaro Izumi; Robert B Campbell; David A Berk; Rakesh K Jain
Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4628-33.
2001: Sergey V Kozin; Yves Boucher; Daniel J Hicklin; P Bohlen; Rakesh K Jain; Herman D Suit
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Cancer research 2001;61(1):39-44.
2000: C G Lee; M Heijn; Emmanuelle di Tomaso; G Griffon-Etienne; Marek Ancukiewicz; Chieko Koike; K R Park; Napoleone Ferrara; Rakesh K Jain; Herman D Suit; Yves Boucher
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Cancer research 2000;60(19):5565-70.
2000: M Stohrer; Yves Boucher; Manfred Stangassinger; Rakesh K Jain
Oncotic pressure in solid tumors is elevated.
Cancer research 2000;60(15):4251-5.
1999: Melody Swartz; A Kaipainen; Paolo A Netti; C Brekken; Yves Boucher; Alan J Grodzinsky; Rakesh K Jain
Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.
Journal of biomechanics 1999;32(12):1297-307.
1999: Takeshi Gohongi; Dai Fukumura; Yves Boucher; CO Yun; Gerald A Soff; Carolyn Corlies Compton; Takeshi Todoroki; Rakesh K Jain
Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.
Nature medicine 1999;5(10):1203-8.
1999: G Griffon-Etienne; Yves Boucher; C Brekken; Herman D Suit; Rakesh K Jain
Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.
Cancer research 1999;59(15):3776-82.
1999: Paolo A Netti; Leena M Hamberg; John W Babich; D Kierstead; W Graham; George J Hunter; G L Wolf; Alan J Fischman; Yves Boucher; Rakesh K Jain
Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3137-42.
1998: Yves Boucher; C Brekken; Paolo A Netti; L T Baxter; Rakesh K Jain
Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.
British journal of cancer 1998;78(11):1442-8.
1997: G Griffon-Etienne; Yves Boucher; Rakesh K Jain; Herman D Suit
Effects of needle insertion in tumors on interstitial fluid pressure.
Microvascular research 1997;54(2):174-7.
1997: Yves Boucher; H Salehi; B Witwer; Griffith R Harsh; Rakesh K Jain
Interstitial fluid pressure in intracranial tumours in patients and in rodents.
British journal of cancer 1997;75(6):829-36.
1996: Yves Boucher; M Leunig; Rakesh K Jain
Tumor angiogenesis and interstitial hypertension.
Cancer research 1996;56(18):4264-6.
1996: CA Kristensen; M Nozue; Yves Boucher; Rakesh K Jain
Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.
British journal of cancer 1996;74(4):533-6.
1996: Paolo A Netti; Sylvie Roberge; Yves Boucher; Laurence T Baxter; Rakesh K Jain
Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.
Microvascular research 1996;52(1):27-46.
1996: C A Znati; M Rosenstein; Yves Boucher; Michael W Epperly; William D Bloomer; Rakesh K Jain
Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Cancer research 1996;56(5):964-68.
1995: Paolo A Netti; Laurence T Baxter; Yves Boucher; R Skalak; Rakesh K Jain
Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.
Cancer research 1995;55(22):5451-8.
1995: R A Zlotecki; Laurence T Baxter; Yves Boucher; Rakesh K Jain
Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.
Microvascular research 1995;50(3):429-43.
1995: Yves Boucher; I Lee; Rakesh K Jain
Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.
Microvascular research 1995;50(2):175-82.
1994: F Yuan; H A Salehi; Yves Boucher; US Vasthare; R F Tuma; Rakesh K Jain
Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.
Cancer research 1994;54(17):4564-8.
1994: I Lee; T J Demhartner; Yves Boucher; Rakesh K Jain; M Intaglietta
Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation.
Microvascular research 1994;48(1):1-12.
1994: I Lee; Yves Boucher; T J Demhartner; Rakesh K Jain
Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline.
British journal of cancer 1994;69(3):492-6.
1993: Paul E.G. Kristjansen; Yves Boucher; Rakesh K Jain
Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.
Cancer research 1993;53(20):4764-6.
1993: R A Zlotecki; Yves Boucher; I Lee; Laurence T Baxter; Rakesh K Jain
Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.
Cancer research 1993;53(11):2466-8.
1992: M Leunig; F Yuan; M D Menger; Yves Boucher; Alwin E Goetz; K Messmer; Rakesh K Jain
Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.
Cancer research 1992;52(23):6553-60.
1992: J R Less; Mitchell C Posner; Yves Boucher; D Borochovitz; Norman Wolmark; R K Jain
Interstitial hypertension in human breast and colorectal tumors.
Cancer research 1992;52(22):6371-4.
1992: Yves Boucher; Rakesh K Jain
Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.
Cancer research 1992;52(18):5110-4.
1992: I Lee; Yves Boucher; Rakesh K Jain
Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.
Cancer research 1992;52(11):3237-40.
1991: H D Roh; Yves Boucher; Shalom Kalnicki; R Buchsbaum; William D Bloomer; R K Jain
Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.
Cancer research 1991;51(24):6695-8.
1991: Yves Boucher; J M Kirkwood; D Opacic; M Desantis; Rakesh K Jain
Interstitial hypertension in superficial metastatic melanomas in humans.
Cancer research 1991;51(24):6691-4.
1990: Yves Boucher; Laurence T Baxter; Rakesh K Jain
Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Cancer research 1990;50(15):4478-84.
1985: Sylvie Roberge; Yves Boucher; P E Roy
Transient ultrastructural variations of pulmonary lymphatic capillaries during the respiratory cycle of the rat lung.
The Anatomical record 1985;213(4):551-9.
1985: Yves Boucher; Sylvie Roberge; P E Roy
Ultrastructural comparative study on lymphatic capillaries of the subendocardium, myocardium, and subepicardium of the heart left ventricle.
Microvascular research 1985;29(3):305-19.

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